Subcellular Location: Nucleus
Found 500 associated metabolites.
6440 associated genes.
A1CF, AAAS, AARS1, AARSD1, AASS, AATF, ABCF2, ABHD14B, ABI1, ABI2, ABITRAM, ABL1, ABRAXAS1, ABRAXAS2, ABT1, ACACB, ACAD11, ACAD9, ACADM, ACADS, ACBD6, ACD, ACHE, ACIN1, ACOT13, ACP3, ACR, ACRBP, ACSS2, ACTB, ACTG1, ACTL6A, ACTL6B, ACTL7A, ACTL7B, ACTN4, ACTR2, ACTR3, ACTR5, ACTR6, ACTR8, ACTRT1, ACTRT3, ADAD1, ADAD2, ADAM10, ADAM19, ADAP1, ADAR, ADARB1, ADAT3, ADCY10, ADD1, ADI1, ADIG, ADIRF, ADK, ADNP, ADNP2, ADPRS, ADRA1A, ADRA1B, ADRB2, ADRM1, AEBP1, AEBP2, AEN, AFF1, AFF3, AFF4, AFG2B, AFMID, AGAP2, AGAP3, AGBL5, AGFG1, AGL, AGO1, AGO2, AGO3, AGO4, AGTPBP1, AHCTF1, AHCY, AHDC1, AHNAK, AHNAK2, AHR, AHRR, AICDA, AIF1, AIFM1, AIFM2, AIM2, AIMP1, AIMP2, AIP, AIPL1, AIRE, AIRIM, AJUBA, AK6, AK9, AKAP13, AKAP17A, AKAP3, AKAP4, AKAP7, AKAP8, AKAP8L, AKIP1, AKIRIN1, AKIRIN2, AKNA, AKR1C3, AKT1, AKT2, AKT3, AKTIP, ALAD, ALB, ALDH7A1, ALDOA, ALG2, ALKBH1, ALKBH2, ALKBH3, ALKBH4, ALKBH5, ALKBH6, ALKBH8, ALOX15B, ALPK3, ALS2, ALX1, ALX3, ALX4, ALYREF, AMBRA1, AMDHD2, AMIGO2, AMMECR1, AMMECR1L, ANAPC11, ANAPC13, ANAPC16, ANAPC4, ANAPC5, ANAPC7, ANG, ANGEL1, ANHX, ANKK1, ANKLE1, ANKRA2, ANKRD1, ANKRD11, ANKRD16, ANKRD17, ANKRD2, ANKRD23, ANKRD31, ANKRD33, ANKRD34B, ANKRD37, ANKRD42, ANKRD49, ANKRD54, ANKRD6, ANP32A, ANP32B, ANP32CP, ANP32E, ANXA1, ANXA10, ANXA11, ANXA13, ANXA2, ANXA2P2, ANXA3, ANXA4, ANXA7, ANXA9, AP5Z1, APAF1, APBA1, APBB1, APBB2, APBB3, APC, APCS, APEX1, APEX2, API5, APLF, APLP2, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, APOBEC3H, APOE, APP, APPBP2, APPL1, APPL2, APTX, AQP1, AQR, AR, ARB2A, ARB2BP, AREG, ARFGEF1, ARG1, ARGFX, ARGLU1, ARHGAP11A, ARHGAP19, ARHGAP22, ARHGAP35, ARHGAP39, ARHGDIA, ARHGEF5, ARID1A, ARID1B, ARID3A, ARID3B, ARID3C, ARID4A, ARID4B, ARID5A, ARID5B, ARIH1, ARIH2, ARK2C, ARK2N, ARL2, ARL2BP, ARL3, ARL4A, ARL4C, ARL4D, ARL6IP4, ARMC12, ARMC8, ARMCX3, ARNT, ARNT2, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARRB1, ARRB2, ART4, ARVCF, ARX, ASAH1, ASB10, ASCC1, ASCC2, ASCC3, ASCL1, ASCL2, ASCL4, ASCL5, ASF1A, ASF1B, ASH1L, ASH2L, ASPA, ASPM, ASPSCR1, ASRGL1, ASXL1, ASXL2, ASXL3, ATAD2, ATAD2B, ATAD5, ATE1, ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, ATF6B, ATF7, ATF7-NPFF, ATF7IP, ATF7IP2, ATL1, ATM, ATMIN, ATN1, ATOH1, ATOH7, ATOH8, ATOSA, ATOSB, ATP5F1B, ATP5PB, ATP5PO, ATR, ATRIP, ATRX, ATXN1, ATXN1L, ATXN3, ATXN3L, ATXN7, ATXN7L3, ATXN8, AUNIP, AURKA, AURKAIP1, AURKB, AURKC, AUTS2, AXIN1, AXIN2, AZGP1, AZIN1, AZIN2, B9D2, BABAM1, BABAM2, BACH1, BACH2, BAG1, BAG3, BAG4, BAG5, BAG6, BAHD1, BANF1, BANF2, BANP, BAP1, BARD1, BARHL1, BARHL2, BARX1, BARX2, BASP1, BATF, BATF2, BATF3, BAX, BAZ1A, BAZ1B, BAZ2A, BAZ2B, BBS4, BBS7, BBX, BCAS2, BCAS3, BCCIP, BCL10, BCL11A, BCL11B, BCL2, BCL2L12, BCL2L13, BCL2L15, BCL3, BCL6, BCL6B, BCL9, BCL9L, BCLAF1, BCOR, BCORL1, BDP1, BECN1, BEND3, BEND6, BEX1, BEX2, BEX3, BEX4, BHLHA15, BHLHA9, BHLHE22, BHLHE23, BHLHE40, BHLHE41, BHMT, BICRA, BIN1, BIRC2, BIRC3, BIRC5, BIRC6, BIRC7, BIRC8, BIVM, BIVM-ERCC5, BLCAP, BLM, BLMH, BLOC1S2, BLTP1, BLZF1, BMAL1, BMAL2, BMI1, BMP2K, BNC1, BNC2, BNIP3, BNIP3L, BNIPL, BOK, BOLA2, BOLA2B, BORA, BORCS8-MEF2B, BPTF, BPY2, BPY2B, BPY2C, BRAF, BRAT1, BRCA1, BRCA2, BRCC3, BRD1, BRD10, BRD2, BRD3, BRD4, BRD7, BRD8, BRD9, BRDT, BRF1, BRF2, BRI3, BRIP1, BRMS1, BRMS1L, BRPF1, BRPF3, BRSK1, BRWD1, BRWD3, BSN, BSX, BTAF1, BTBD10, BTBD18, BTBD3, BTBD7, BTBD8, BTF3, BTG1, BTG2, BTG3, BTG4, BTK, BTRC, BUB1, BUB1B, BUB3, BUD13, BUD23, BUD31, C11orf54, C12orf43, C15orf48, C16orf78, C17orf49, C19orf33, C19orf47, C1D, C1orf174, C1QBP, C2CD2, C2CD4A, C2CD4B, C2orf42, C2orf49, C2orf81, C3orf38, C6orf52, C8orf17, C9orf72, C9orf78, CA9, CABIN1, CABLES1, CABYR, CACNA1A, CACTIN, CACYBP, CAD, CALB1, CALB2, CALCOCO1, CALCOCO2, CALM1, CALM2, CALM3, CALML6, CALR, CAMK1, CAMK1D, CAMK2A, CAMK2D, CAMK2N2, CAMK4, CAMKK1, CAMKK2, CAMKMT, CAMP, CAMTA1, CAMTA2, CAND1, CAND2, CAPG, CAPN2, CAPN3, CAPN7, CAPZA3, CARD19, CARD8, CARF, CARM1, CARNMT1, CASC3, CASK, CASP14, CASP2, CASP3, CASP6, CASP7, CASP8, CASP8AP2, CASP9, CASZ1, CATIP, CAV2, CAVIN1, CBFA2T2, CBFA2T3, CBFB, CBLL1, CBS, CBX1, CBX2, CBX3, CBX4, CBX5, CBX6, CBX7, CBX8, CBY1, CC2D1A, CC2D1B, CCAR1, CCAR2, CCDC106, CCDC110, CCDC117, CCDC124, CCDC134, CCDC137, CCDC174, CCDC32, CCDC59, CCDC62, CCDC69, CCDC82, CCDC85B, CCDC86, CCDC89, CCDC97, CCHCR1, CCIN, CCN1, CCN5, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCNC, CCND1, CCND2, CCND3, CCNDBP1, CCNE1, CCNE2, CCNF, CCNG1, CCNG2, CCNH, CCNI, CCNI2, CCNJ, CCNJL, CCNK, CCNL1, CCNL2, CCNO, CCNP, CCNQ, CCNT1, CCNT2, CCNY, CCR4, CCS, CD274, CD2BP2, CD74, CDADC1, CDAN1, CDC14A, CDC14B, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC34, CDC40, CDC45, CDC5L, CDC6, CDC7, CDC73, CDCA2, CDCA4, CDCA5, CDCA7, CDCA7L, CDH1, CDIN1, CDIP1, CDK1, CDK10, CDK11A, CDK11B, CDK12, CDK13, CDK14, CDK15, CDK16, CDK17, CDK18, CDK19, CDK2, CDK20, CDK2AP1, CDK2AP2, CDK3, CDK4, CDK5, CDK5R1, CDK5RAP3, CDK6, CDK7, CDK8, CDK9, CDKL1, CDKL2, CDKL3, CDKL4, CDKL5, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CDKN3, CDS1, CDT1, CDX1, CDX2, CDX4, CDY1, CDY1B, CDY2A, CDY2B, CDYL, CDYL2, CEBPA, CEBPB, CEBPD, CEBPE, CEBPG, CEBPZ, CECR2, CELF1, CELF2, CELF3, CELF4, CELF5, CELF6, CEMP1, CENPA, CENPB, CENPBD1P, CENPC, CENPE, CENPF, CENPH, CENPI, CENPK, CENPL, CENPM, CENPN, CENPO, CENPP, CENPQ, CENPS, CENPT, CENPU, CENPV, CENPW, CENPX, CEP290, CEP350, CEP43, CEP57, CERS2, CERS3, CERS4, CERS5, CES1, CETN1, CETN2, CFAP20, CFAP298, CFAP299, CFAP36, CFAP45, CFAP68, CFAP74, CFDP1, CFL1, CFTR, CGAS, CGGBP1, CGRRF1, CHAF1A, CHAF1B, CHAMP1, CHAT, CHCHD1, CHCHD10, CHCHD2, CHCHD2P9, CHCHD3, CHD1, CHD1L, CHD2, CHD3, CHD4, CHD5, CHD6, CHD7, CHD8, CHD9, CHEK1, CHEK2, CHFR, CHID1, CHL1, CHM, CHML, CHMP4A, CHMP4B, CHP1, CHP2, CHRAC1, CHTF18, CHTF8, CHTOP, CHUK, CIAO2B, CIAPIN1, CIART, CIB1, CIBAR1, CIC, CIDEA, CIDEC, CIITA, CILK1, CIMAP3, CIMIP2A, CIMIP2C, CINP, CIPC, CIR1, CIRBP, CITED1, CITED2, CITED4, CIZ1, CKLF, CLASRP, CLDN19, CLIC1, CLIC2, CLIC3, CLIC4, CLIP1, CLIP2, CLIP3, CLIP4, CLK1, CLK2, CLK3, CLK4, CLN3, CLNS1A, CLOCK, CLP1, CLSPN, CLSTN1, CLU, CLUAP1, CLUL1, CMAHP, CMAS, CMIP, CMPK1, CMTR1, CMTR2, CMYA5, CNBP, CNEP1R1, CNOT1, CNOT10, CNOT11, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT9, CNPPD1, CNTD1, CNTRL, COIL, COMMD1, COMMD10, COMMD3, COMMD3-BMI1, COMMD4, COMMD5, COMMD6, COMMD8, COMMD9, COPRS, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7A, COPS7B, COPS8, COPS9, COQ7, COTL1, CPEB1, CPEB2, CPEB3, CPEB4, CPHXL, CPHXL2, CPLX2, CPN1, CPNE1, CPNE2, CPNE3, CPNE7, CPSF1, CPSF2, CPSF3, CPSF4, CPSF4L, CPSF6, CPSF7, CRABP1, CRABP2, CRADD, CRAMP1, CRBN, CRCP, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, CREBBP, CREBL2, CREBRF, CREBZF, CREM, CRHBP, CRISP1, CRK, CRLF3, CRNKL1, CRTC1, CRTC2, CRTC3, CRX, CRY1, CRY2, CRYAA, CRYAB, CRYBA1, CRYGB, CRYGC, CRYGD, CRYM, CS, CSDC2, CSE1L, CSN2, CSN3, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, CSNKA2IP, CSP1, CSRNP1, CSRNP2, CSRNP3, CSRP1, CSRP2, CSRP3, CST11, CST6, CSTB, CSTF1, CSTF2, CSTF2T, CSTF3, CT83, CTBP1, CTBP1-DT, CTBP2, CTC1, CTCF, CTCFL, CTDP1, CTDSP1, CTDSP2, CTDSPL, CTNNA1, CTNNA2, CTNNB1, CTNNBIP1, CTNNBL1, CTNND1, CTNND2, CTR9, CTSG, CTSL, CUEDC2, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUTC, CUX1, CUX2, CWC15, CWC22, CWC25, CWC27, CXXC1, CXXC5, CYB5R2, CYC1, CYCS, CYFIP2, CYGB, CYLC1, CYLC2, CYREN, DACH1, DACH2, DACT1, DAP, DAPK1, DAPK2, DAPK3, DAXX, DAZ1, DAZ2, DAZ3, DAZ4, DAZAP1, DAZAP2, DAZL, DBF4, DBF4B, DBP, DBR1, DBX1, DBX2, DCAF1, DCAF12, DCAF16, DCAF5, DCAF6, DCAF7, DCAF8, DCAF8L1, DCAF8L2, DCANP1, DCK, DCLK3, DCLRE1A, DCLRE1B, DCLRE1C, DCP1A, DCP1B, DCP2, DCPS, DCTN4, DCTPP1, DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, DCXR, DDB1, DDB2, DDIAS, DDIT3, DDN, DDX1, DDX10, DDX11, DDX11L8, DDX12P, DDX17, DDX19A, DDX19B, DDX20, DDX21, DDX23, DDX25, DDX28, DDX31, DDX39A, DDX39B, DDX3X, DDX3Y, DDX4, DDX41, DDX42, DDX46, DDX47, DDX49, DDX5, DDX51, DDX53, DDX54, DDX56, DDX59, DDX6, DEAF1, DECR1, DEF6, DEFB106A, DEFB106B, DEK, DENND4A, DEPDC1, DERA, DERPC, DES, DESI1, DET1, DFFA, DFFB, DGCR6, DGCR6L, DGCR8, DGKD, DGKI, DGKQ, DGKZ, DGUOK, DHCR24, DHRS2, DHRS4, DHRS7B, DHX15, DHX16, DHX30, DHX32, DHX33, DHX36, DHX38, DHX8, DHX9, DIAPH1, DIAPH3, DICER1, DIDO1, DIP2B, DIS3, DKC1, DKFZP586I1420, DLC1, DLD, DLG1, DLGAP5, DLST, DLX1, DLX2, DLX3, DLX4, DLX5, DLX6, DMAP1, DMBX1, DMC1, DMD, DMP1, DMRT1, DMRT2, DMRT3, DMRTA1, DMRTA2, DMRTB1, DMRTC1B, DMRTC2, DMTF1, DMWD, DNA2, DNAAF4, DNAJA1, DNAJA3, DNAJB1, DNAJB11, DNAJB2, DNAJB6, DNAJB7, DNAJB8, DNAJC17, DNAJC2, DNAJC21, DNAJC27, DNAJC7, DNAJC8, DNAJC9, DNASE1, DNASE1L1, DNASE1L2, DNASE1L3, DND1, DNLZ, DNMT1, DNMT3A, DNMT3B, DNMT3L, DNPEP, DNPH1, DNTT, DNTTIP1, DNTTIP2, DOCK10, DOK1, DONSON, DOT1L, DPCD, DPF1, DPF2, DPF3, DPH1, DPH3, DPM1, DPP9, DPPA2, DPPA3, DPPA4, DPRX, DPY19L2, DPY30, DQX1, DR1, DRAP1, DRD1, DRG1, DRG2, DRGX, DROSHA, DSC1, DSCC1, DSG1, DSN1, DSP, DSPP, DST, DTD1, DTL, DTNB, DTNBP1, DTWD1, DTWD2, DTX2, DTX3L, DTYMK, DUSP1, DUSP10, DUSP11, DUSP12, DUSP16, DUSP18, DUSP2, DUSP21, DUSP26, DUSP29, DUSP3, DUSP4, DUSP5, DUSP8, DUSP9, DUT, DUX1, DUX3, DUX4, DUX4L2, DUX4L3, DUX4L4, DUX4L5, DUX4L6, DUX4L7, DUX4L9, DUX5, DUXA, DUXB, DVL2, DXO, DYNC1I1, DYNLL1, DYNLL2, DYNLT3, DYNLT4, DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, DZIP1, E2F1, E2F3, E2F4, E2F5, E2F6, E2F7, E2F8, EAF1, EAF2, EAPP, EBF1, EBF2, EBF3, EBF4, ECD, ECPAS, ECSIT, ECT2, EDC4, EDF1, EDRF1, EED, EEF1A1, EEF1A1P5, EEF1A2, EEF1AKMT2, EEF1D, EEF1E1, EEF1G, EEF2, EEFSEC, EEIG1, EFCAB6, EFNB1, EFTUD2, EGFR, EGLN1, EGLN2, EGLN3, EGR1, EGR2, EGR3, EGR4, EHD2, EHD3, EHD4, EHF, EHMT1, EHMT2, EID1, EID2, EID2B, EID3, EIF1, EIF1AD, EIF2A, EIF2AK1, EIF2AK2, EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF3A, EIF3E, EIF3G, EIF3K, EIF4A3, EIF4E, EIF4EBP1, EIF4EBP2, EIF4EBP3, EIF4ENIF1, EIF4G1, EIF5A, EIF5A2, EIF5AL1, EIF6, ELAC1, ELAC2, ELAVL1, ELF1, ELF2, ELF3, ELF4, ELF5, ELK1, ELK3, ELK4, ELL, ELL3, ELOA, ELOA2, ELOB, ELOC, ELOF1, ELP1, ELP2, ELP3, ELP4, ELP5, ELP6, EME1, EME2, EMG1, EML3, EMP2, EMSY, EMX1, EMX2, EN1, EN2, ENC1, ENDOG, ENO1, ENOPH1, EOMES, EP300, EP400, EPAS1, EPB41, EPC1, EPC2, EPM2A, EPM2AIP1, EPN1, EPN3, EPOP, EPS15L1, ERBB2, ERBB4, ERBIN, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L2, ERCC8, ERF, ERFL, ERG, ERGIC2, ERH, ERI1, ERRFI1, ERVK-10, ERVK-24, ERVK-5, ERVK-7, ESCO1, ESCO2, ESPL1, ESR1, ESR2, ESRG, ESRP1, ESRP2, ESRRA, ESRRB, ESRRG, ESS2, ESX1, ETAA1, ETHE1, ETS1, ETS2, ETV1, ETV2, ETV3, ETV3L, ETV4, ETV5, ETV6, ETV7, EVC2, EVI5, EVX1, EVX2, EWSR1, EXD2, EXO1, EXO5, EXOG, EXOSC1, EXOSC10, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8, EXOSC9, EXTL3, EYA1, EYA2, EYA3, EYA4, EZH1, EZH2, EZHIP, F10, F8A3, FAAP100, FAAP20, FAAP24, FABP1, FABP12, FABP2, FABP3, FABP4, FABP5, FABP5P3, FABP6, FABP7, FABP9, FAF1, FAM107A, FAM110A, FAM110C, FAM111A, FAM111B, FAM120A, FAM120B, FAM120C, FAM124B, FAM170A, FAM193B, FAM209A, FAM209B, FAM220A, FAM220BP, FAM47E, FAM50A, FAM50B, FAM53A, FAM53B, FAM53C, FAM81B, FAM83G, FAM98A, FAM98B, FAM9B, FAM9C, FAN1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FANK1, FASLG, FAT1, FAU, FBH1, FBL, FBP1, FBP2, FBXL17, FBXL19, FBXL21P, FBXL3, FBXL5, FBXO11, FBXO22, FBXO25, FBXO3, FBXO32, FBXO38, FBXO43, FBXO45, FBXO5, FBXO7, FBXW11, FBXW7, FEM1B, FEN1, FER, FERD3L, FERMT2, FEV, FEZF1, FEZF2, FGD2, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF2, FGFR1, FGFR2, FH, FHIT, FHL1, FHL2, FHL3, FHL5, FHOD1, FIBP, FIGLA, FIGNL1, FILIP1L, FIP1L1, FIRRM, FIZ1, FKBP3, FKBP4, FKBP5, FKBP6, FKTN, FLCN, FLG, FLG2, FLI1, FLII, FLNA, FLT4, FLYWCH1, FMN1, FMN2, FMR1, FNDC8, FOLR1, FOS, FOSB, FOSL1, FOSL2, FOXA1, FOXA2, FOXA3, FOXB1, FOXB2, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD4L1, FOXD4L3, FOXD4L4, FOXD4L5, FOXD4L6, FOXE1, FOXE3, FOXF1, FOXF2, FOXG1, FOXH1, FOXI1, FOXI2, FOXI3, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXL3, FOXM1, FOXN1, FOXN2, FOXN3, FOXN4, FOXO1, FOXO3, FOXO3B, FOXO4, FOXO6, FOXP1, FOXP2, FOXP3, FOXP4, FOXQ1, FOXR1, FOXR2, FOXS1, FRA10AC1, FRAT1, FRAT2, FRG2, FRG2B, FRG2C, FRK, FSBP, FSD1, FSD2, FST, FSTL3, FTH1, FTMT, FTO, FTSJ1, FUBP1, FUBP3, FUNDC2, FUS, FXR1, FXR2, FYB1, FYN, FZR1, G2E3, G3BP1, GABPA, GABPB1, GABPB2, GADD45A, GADD45B, GADD45G, GADD45GIP1, GAMT, GAPDH, GAPDHS, GARIN3, GARIN4, GATA1, GATA2, GATA3, GATA4, GATA5, GATA6, GATAD1, GATAD2A, GATAD2B, GBP2, GBP4, GBX1, GBX2, GCAT, GCFC2, GCH1, GCHFR, GCK, GCKR, GCM1, GCM2, GCNA, GCOM1, GDAP1, GDF15, GEM, GEMIN2, GEMIN5, GEMIN6, GEMIN8, GEN1, GET1, GFI1, GFI1B, GGH, GGNBP2, GID8, GINS1, GINS2, GINS3, GINS4, GJA1, GK, GLE1, GLI1, GLI2, GLI3, GLI4, GLIS1, GLIS2, GLIS3, GLMP, GLRX, GLRX2, GLRX3, GLUL, GLYR1, GMCL1, GMCL2, GMEB1, GMEB2, GMNC, GMNN, GNA13, GNAI1, GNAQ, GNAS, GNB1L, GNB5, GNL1, GNL2, GNL3, GNPDA2, GON4L, GON7, GOT1, GPATCH1, GPATCH2, GPATCH2L, GPATCH3, GPATCH8, GPBP1, GPBP1L1, GPC4, GPC6, GPER1, GPKOW, GPN1, GPR158, GPR88, GPRASP1, GPRASP2, GPRASP3, GPS1, GPS2, GPX4, GRAP2, GRB2, GRHL1, GRHL2, GRHL3, GRIP1, GRM1, GRWD1, GSC, GSC2, GSK3A, GSK3B, GSKIP, GSTM3, GSTP1, GSTT2, GSX1, GSX2, GTDC1, GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H2, GTF2H2C, GTF2H2C_2, GTF2H3, GTF2H4, GTF2H5, GTF2I, GTF2IRD1, GTF2IRD2, GTF2IRD2B, GTF3A, GTF3C2, GTF3C5, GTF3C6, GTPBP3, GTPBP4, GVINP1, GYG1, GYG2, GZMA, GZMB, H1-0, H1-1, H1-10, H1-2, H1-3, H1-4, H1-5, H1-6, H1-7, H1-8, H1-9P, H2AB1, H2AB2, H2AB3, H2AC1, H2AC11, H2AC12, H2AC13, H2AC14, H2AC15, H2AC16, H2AC17, H2AC18, H2AC19, H2AC20, H2AC21, H2AC25, H2AC4, H2AC6, H2AC7, H2AC8, H2AJ, H2AL1Q, H2AL3, H2AP, H2AX, H2AZ1, H2AZ2, H2BC1, H2BC10, H2BC11, H2BC12, H2BC12L, H2BC13, H2BC14, H2BC15, H2BC17, H2BC18, H2BC19P, H2BC20P, H2BC21, H2BC26, H2BC3, H2BC4, H2BC5, H2BC6, H2BC7, H2BC8, H2BC9, H2BK1, H2BN1, H2BW1, H2BW2, H3-3A, H3-3B, H3-4, H3-5, H3-7, H3C1, H3C10, H3C11, H3C12, H3C13, H3C14, H3C15, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3Y1, H3Y2, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C7, H4C8, H4C9, HABP4, HACE1, HAMP, HAND1, HAND2, HAP1, HAPSTR1, HAPSTR2, HARBI1, HARS2, HAS3, HASPIN, HAT1, HAX1, HBP1, HCFC1, HCFC1R1, HCFC2, HCK, HCLS1, HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDC, HDGF, HDGFL1, HDGFL2, HDGFL3, HDHD3, HDLBP, HDX, HECA, HELB, HELLS, HELQ, HELT, HELZ, HEMGN, HENMT1, HERC2, HES1, HES2, HES3, HES4, HES5, HES6, HES7, HESX1, HEXD, HEXIM1, HEXIM2, HEY1, HEY2, HEYL, HFM1, HHEX, HIC1, HIC2, HIF1A, HIF3A, HIKESHI, HINFP, HINT1, HINT3, HIP1, HIPK1, HIPK2, HIPK3, HIPK4, HIRA, HIRIP3, HIVEP1, HIVEP2, HIVEP3, HJURP, HLF, HLTF, HLX, HMBOX1, HMG20A, HMG20B, HMGA1, HMGA2, HMGB1, HMGB1P1, HMGB2, HMGB3, HMGB4, HMGN1, HMGN2, HMGN2P46, HMGN3, HMGN4, HMGN5, HMGXB3, HMGXB4, HMOX1, HMX1, HMX2, HMX3, HNF1A, HNF1B, HNF4A, HNF4G, HNRNPA0, HNRNPA1, HNRNPA1L2, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPCL1, HNRNPCL2, HNRNPCL3, HNRNPCL4, HNRNPD, HNRNPDL, HNRNPF, HNRNPH1, HNRNPH2, HNRNPH3, HNRNPK, HNRNPL, HNRNPLL, HNRNPM, HNRNPR, HNRNPU, HNRNPUL1, HNRNPUL2, HNRNPUL2-BSCL2, HOMEZ, HOPX, HORMAD1, HORMAD2, HOXA1, HOXA10, HOXA11, HOXA13, HOXA3, HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXB1, HOXB13, HOXB3, HOXB5, HOXB6, HOXB7, HOXB8, HOXB9, HOXC10, HOXC11, HOXC12, HOXC13, HOXC4, HOXC5, HOXC6, HOXC8, HOXC9, HOXD1, HOXD10, HOXD11, HOXD12, HOXD13, HOXD3, HOXD8, HOXD9, HP1BP3, HPF1, HPSE, HRNR, HROB, HSBP1, HSBP1L1, HSF1, HSF2, HSF4, HSF5, HSFX1, HSFX2, HSFX3, HSFX4, HSFY1, HSFY2, HSH2D, HSP90AA1, HSP90AA4P, HSP90AB1, HSP90B1, HSPA12A, HSPA13, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4, HSPA4L, HSPA5, HSPA6, HSPA7, HSPA8, HSPA9, HSPB1, HSPB2, HSPB2-C11orf52, HSPB3, HSPB6, HSPB7, HSPB8, HSPB9, HSPH1, HTATIP2, HTATSF1, HTRA2, HTT, HUS1, HUWE1, HYLS1, HYPK, ICE1, ICE2, ID1, ID2, ID3, ID4, IDE, IDH3A, IDH3B, IER2, IER3, IER5, IFFO1, IFI16, IFI35, IFIH1, IFRD1, IFRD2, IFT27, IFT74, IGF2BP1, IGF2BP2, IGF2BP3, IGFBP3, IGFBP5, IGFN1, IGHMBP2, IK, IKBKB, IKBKE, IKBKG, IKZF1, IKZF2, IKZF3, IKZF4, IKZF5, IL16, IL1A, IL33, IL37, ILDR2, ILF2, ILF3, ILK, ILRUN, IMP3, IMPDH1, IMPDH2, INAVA, INCA1, INCENP, ING1, ING2, ING3, ING4, ING5, INIP, INKA1, INKA2, INO80, INO80B, INO80C, INO80D, INO80E, INPP4A, INPP5E, INPP5K, INPPL1, INSM1, INSM2, INTS1, INTS10, INTS11, INTS12, INTS13, INTS14, INTS15, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9, INVS, IP6K1, IP6K2, IP6K3, IPMK, IPO11, IPO13, IPO4, IPO5, IPO7, IPO8, IPO9, IPPK, IQCN, IQGAP1, IQSEC1, IRAK1, IRAK1BP1, IRAK2, IRAK3, IRAK4, IRF1, IRF2, IRF2BP1, IRF2BP2, IRF2BPL, IRF3, IRF4, IRF5, IRF6, IRF7, IRF8, IRF9, IRS1, IRX1, IRX2, IRX3, IRX4, IRX5, IRX6, ISCU, ISG20, ISG20L2, ISL1, ISL2, ISOC2, ISX, ISY1, ITCH, ITGB1BP1, ITGB3, ITGB3BP, ITK, ITPKA, ITPKB, ITPKC, IWS1, IZUMO4, JADE1, JAK1, JAK2, JARID2, JAZF1, JDP2, JMJD1C, JMJD4, JMJD6, JMJD7, JMJD8, JMY, JPH2, JPT1, JPT2, JRK, JRKL, JUN, JUNB, JUND, JUP, KANK1, KANSL1, KANSL2, KANSL3, KARS1, KASH5, KAT14, KAT2A, KAT2B, KAT5, KAT6A, KAT6B, KAT7, KAT8, KATNB1, KATNBL1, KBTBD6, KBTBD7, KCNIP3, KCTD1, KCTD10, KCTD13, KCTD15, KCTD19, KCTD5, KDM1A, KDM1B, KDM2A, KDM2B, KDM3A, KDM3B, KDM4A, KDM4B, KDM4C, KDM4D, KDM4E, KDM4F, KDM5A, KDM5B, KDM5C, KDM5D, KDM6A, KDM6B, KDM7A, KDM8, KDR, KEAP1, KHDC3L, KHDC4, KHDRBS1, KHDRBS2, KHDRBS3, KHNYN, KHSRP, KIAA1614, KIF11, KIF14, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KIFC2, KIN, KLF1, KLF10, KLF11, KLF13, KLF14, KLF15, KLF16, KLF17, KLF18, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLHDC10, KLHDC2, KLHL15, KLHL22, KLHL31, KLHL7, KLK1, KLK3, KLKP1, KLLN, KMT2A, KMT2B, KMT2C, KMT2D, KMT2E, KMT5A, KMT5B, KMT5C, KNL1, KNSTRN, KNTC1, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNA7, KPNB1, KRBOX5, KRR1, KRT1, KRT10, KRT13, KRT14, KRT15, KRT16, KRT2, KRT4, KRT5, KRT6A, KRT7, KRT73, KRT76, KRT8, KRT9, L3MBTL1, L3MBTL2, L3MBTL3, L3MBTL4, LACC1, LAGE3, LAMA5, LANCL2, LAP3, LARP1B, LARP6, LARP7, LATS1, LATS2, LBH, LBHD1, LBR, LBX1, LBX2, LCOR, LCORL, LDB1, LDB2, LDHA, LDHAL6B, LDHC, LDOC1, LEF1, LEMD2, LENG8, LEO1, LETMD1, LEUTX, LGALS12, LGALS14, LGALS3, LGALS7, LGALS7B, LGALS9, LGALS9B, LGALS9C, LHPP, LHX1, LHX2, LHX3, LHX4, LHX5, LHX6, LHX8, LHX9, LIG1, LIG3, LIG4, LIMD1, LIMD2, LIMK1, LIMK2, LIMS2, LIN28A, LIN28B, LIN54, LIN9, LINC-PINT, LINC02914, LITAF, LITAFD, LMCD1, LMNA, LMNB1, LMO1, LMO2, LMO3, LMO7, LMX1A, LMX1B, LOC107987545, LOC122539214, LOC124905412, LOC728743, LONP2, LOXL2, LOXL3, LPIN1, LPIN2, LPIN3, LPP, LPXN, LRP1, LRPPRC, LRR1, LRRC10, LRRC34, LRRC41, LRRFIP1, LRWD1, LSM1, LSM10, LSM11, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, LTA4H, LTF, LTO1, LTV1, LUC7L3, LUZP1, LUZP4, LYAR, LYL1, LYN, LYRM1, LYRM4, LYZL4, MAB21L1, MAB21L2, MACC1, MACO1, MACROD1, MACROD2, MACROH2A1, MACROH2A2, MAD1L1, MAD2L1, MAD2L1BP, MAD2L2, MAEA, MAEL, MAF, MAF1, MAFA, MAFB, MAFF, MAFG, MAFK, MAGEA1, MAGEA10, MAGEA11, MAGEA12, MAGEA13P, MAGEA2, MAGEA2B, MAGEA3, MAGEA4, MAGEA6, MAGEA8, MAGEA9, MAGEA9B, MAGEB1, MAGEB10, MAGEB16, MAGEB17, MAGEB18, MAGEB2, MAGEB3, MAGEB4, MAGEB5, MAGEB6, MAGEB6B, MAGEC1, MAGEC2, MAGEC3, MAGED1, MAGED2, MAGED4, MAGED4B, MAGEE1, MAGEE2, MAGEF1, MAGEH1, MAGEL2, MAGI2, MAGI3, MAGOH, MAGOHB, MAK, MAK16, MAL, MALT1, MAML1, MAML2, MAML3, MAMLD1, MAMSTR, MANF, MAP1S, MAP2K1, MAP2K2, MAP2K4, MAP2K6, MAP2K7, MAP3K2, MAP3K20, MAP3K7, MAP3K7CL, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK15, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK8IP1, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPKBP1, MAPT, MARCHF7, MARVELD1, MARVELD3, MASTL, MAT2B, MATR3, MAU2, MAX, MAZ, MBD1, MBD2, MBD3, MBD3L1, MBD3L2, MBD3L2B, MBD3L3, MBD3L4, MBD3L5, MBD4, MBD5, MBD6, MBLAC1, MBNL1, MBNL2, MBNL3, MBP, MBTD1, MCC, MCIDAS, MCL1, MCM10, MCM2, MCM3, MCM3AP, MCM4, MCM5, MCM6, MCM7, MCM8, MCM9, MCMBP, MCRIP1, MCRIP2, MCRS1, MDC1, MDFI, MDFIC, MDH2, MDM1, MDM2, MDM4, MDN1, MEAF6, MECOM, MECP2, MECR, MED1, MED10, MED11, MED12, MED12L, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED28, MED29, MED30, MED31, MED4, MED6, MED7, MED8, MED9, MEF2A, MEF2B, MEF2C, MEF2D, MEFV, MEGF8, MEIG1, MEIOB, MEIOC, MEIOSIN, MEIS1, MEIS2, MEIS3, MEIS3P1, MEIS3P2, MEMO1, MEN1, MEOX1, MEOX2, MEPCE, MESP1, MESP2, MET, METTL1, METTL13, METTL14, METTL16, METTL18, METTL21C, METTL22, METTL23, METTL3, METTL4, METTL5, METTL6, METTL8, MEX3A, MEX3B, MEX3C, MEX3D, MFAP1, MFAP3L, MGA, MGC16025, MGMT, MGRN1, MICAL2, MICAL3, MID1, MID1IP1, MIDEAS, MIDN, MIER1, MIER2, MIER3, MIF4GD, MINDY3, MIPOL1, MIR155HG, MIR9-1HG, MIS12, MIS18A, MIS18BP1, MITF, MIXL1, MKI67, MKKS, MKNK1, MKNK2, MKRN2, MKX, MLF1, MLF2, MLH1, MLH3, MLIP, MLKL, MLLT10, MLLT11, MLLT3, MLLT6, MLX, MLXIP, MLXIPL, MMP12, MMP14, MMP2, MMP3, MMS19, MMS22L, MN1, MNAT1, MND1, MNDA, MNS1, MNX1, MOB1A, MOB1B, MOB2, MOB3A, MOB3B, MOB3C, MOCS1, MOK, MORC1, MORC2, MORC3, MORC4, MORF4L1, MORF4L2, MORN2, MORN3, MOSPD1, MOV10, MPC2, MPG, MPHOSPH6, MPHOSPH8, MPLKIP, MPO, MPP2, MPP7, MR1, MRE11, MRFAP1, MRI1, MRNIP, MRPL15, MRPL19, MRPL40, MRPL44, MRPS5, MRTFA, MRTFB, MSANTD4, MSC, MSGN1, MSH2, MSH3, MSH4, MSH5, MSH5-SAPCD1, MSH6, MSI1, MSL1, MSL2, MSL3, MSL3B, MSMB, MSN, MSRB1, MST1, MSX1, MSX2, MT-RNR1, MT-RNR2, MT1A, MT1B, MT1DP, MT1E, MT1F, MT1G, MT1H, MT1HL1, MT1L, MT1M, MT1X, MT2A, MT3, MT4, MTA1, MTA2, MTA3, MTAP, MTCH2, MTDH, MTF1, MTF2, MTMR2, MTOR, MTPN, MTREX, MTUS1, MTUS2, MUC1, MUS81, MUSTN1, MUTYH, MVB12A, MVB12B, MVP, MX1, MX2, MXD1, MXD3, MXD4, MXI1, MXRA8, MYB, MYBBP1A, MYBL1, MYBL2, MYC, MYCBP, MYCBP2, MYCL, MYCLP1, MYCN, MYCNOS, MYCT1, MYD88, MYEF2, MYF5, MYF6, MYG1, MYH10, MYH9, MYLK2, MYNN, MYO18A, MYO18B, MYO1C, MYO6, MYOCD, MYOD1, MYOG, MYOZ1, MYPN, MYPOP, MYRF, MYRFL, MYSM1, MYT1, MYT1L, MZF1, N4BP1, N4BP2L2, N6AMT1, NAA10, NAA11, NAA15, NAA16, NAA20, NAA30, NAA38, NAA40, NAA50, NAB1, NAB2, NABP1, NABP2, NACA, NACA2, NACAD, NACC1, NACC2, NAE1, NAF1, NAIF1, NAMPT, NANOG, NANOGNB, NANOGP1, NANOGP8, NANOS2, NANOS3, NAP1L1, NAP1L2, NAP1L3, NAP1L4, NAP1L5, NAP1L6P, NARF, NASP, NAT10, NAT14, NAT2, NAV2, NAXE, NBEA, NBN, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NCAPH2, NCBP1, NCBP2, NCBP3, NCK1, NCKIPSD, NCL, NCOA1, NCOA2, NCOA3, NCOA4, NCOA6, NCOA7, NCOR1, NCOR2, NDC80, NDN, NDRG1, NDRG2, NDUFA13, NDUFA9, NDUFAF3, NDUFAF6, NECAB3, NEDD4, NEDD4L, NEDD8, NEDD9, NEIL1, NEIL2, NEIL3, NEK1, NEK11, NEK2, NEK3, NEK6, NEK7, NEK8, NEK9, NELFA, NELFB, NELFCD, NELFE, NEMF, NEPRO, NET1, NEUROD1, NEUROD2, NEUROD4, NEUROD6, NEUROG1, NEUROG2, NEUROG3, NEXMIF, NF1, NF2, NFAT5, NFATC1, NFATC2, NFATC2IP, NFATC3, NFATC4, NFE2, NFE2L1, NFE2L2, NFE2L3, NFE4, NFIA, NFIB, NFIC, NFIL3, NFILZ, NFIX, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBID, NFKBIL1, NFKBIZ, NFRKB, NFS1, NFU1, NFX1, NFXL1, NFYA, NFYB, NFYC, NGDN, NGLY1, NGRN, NHEJ1, NHERF2, NHLH1, NHLH2, NHLRC1, NIBAN2, NICN1, NIF3L1, NIPBL, NIPSNAP3A, NIT1, NKAP, NKAPL, NKRF, NKTR, NKX1-1, NKX1-2, NKX2-1, NKX2-2, NKX2-3, NKX2-4, NKX2-5, NKX2-6, NKX2-8, NKX3-1, NKX3-2, NKX6-1, NKX6-2, NKX6-3, NLE1, NLK, NLRC5, NLRP1, NLRP2B, NLRP3, NLRP5, NMD3, NME1, NME2, NME2P1, NME7, NME8, NMI, NMNAT1, NMRAL1, NOB1, NOBOX, NOC2L, NOCT, NOL12, NOL9, NONO, NOP2, NOPCHAP1, NOS1, NOS1AP, NOS2, NOS3, NOSIP, NOSTRIN, NOTCH1, NOTCH2, NOTCH4, NOTO, NOVA1, NOVA2, NOX4, NPAS1, NPAS2, NPAS3, NPAS4, NPAT, NPEPL1, NPEPPS, NPHP4, NPIPB2, NPLOC4, NPM1, NPM2, NPM3, NPR2, NQO1, NR0B1, NR0B2, NR1D1, NR1D2, NR1H2, NR1H3, NR1H4, NR1I2, NR1I3, NR2C1, NR2C2, NR2C2AP, NR2E1, NR2E3, NR2F1, NR2F2, NR2F6, NR3C1, NR3C2, NR4A1, NR4A2, NR4A3, NR5A1, NR5A2, NR6A1, NRBF2, NRDE2, NRF1, NRIP1, NRIP2, NRL, NSD1, NSD2, NSD3, NSFL1C, NSG1, NSL1, NSMCE1, NSMCE2, NSMCE3, NSMCE4A, NSMF, NSRP1, NSUN2, NT5C, NT5C1B, NTAN1, NTAQ1, NTHL1, NTMT1, NTMT2, NUAK1, NUB1, NUBP1, NUBP2, NUCKS1, NUDC, NUDCD1, NUDT1, NUDT10, NUDT11, NUDT12, NUDT16, NUDT16L1, NUDT21, NUDT3, NUDT4, NUDT4B, NUDT5, NUDT6, NUF2, NUFIP1, NUFIP2, NUMA1, NUP160, NUP205, NUP37, NUP42, NUP43, NUP54, NUP98, NUPR1, NUPR2, NUSAP1, NUTF2, NUTM1, NVL, NXF1, NXF2, NXF2B, NXF3, NXF5, NXN, NXT1, NXT2, NYNRIN, OAS1, OAZ1, OAZ2, OAZ3, OBSCN, OCRL, ODAM, ODCP, ODF1, ODF2, OFD1, OGA, OGDH, OGFR, OGG1, OGT, OIP5, OLA1, OLFM2, OLIG1, OLIG2, OLIG3, OMP, ONECUT1, ONECUT2, ONECUT3, OOEP, OPTN, ORC1, ORC2, ORC3, ORC4, ORC5, ORC6, OSGEP, OSR1, OSR2, OTP, OTUB2, OTUD3, OTUD4, OTUD5, OTUD7A, OTUD7B, OTX1, OTX2, OVCA2, OVOL1, OVOL2, OVOL3, OXR1, P3H1, PA2G4, PABIR1, PABPC1, PABPC1L, PABPC1L2A, PABPC1L2B, PABPC3, PABPC4, PABPC4L, PABPC5, PABPN1, PABPN1L, PACRG, PADI1, PADI2, PADI3, PADI4, PADI6, PAF1, PAGE4, PAGR1, PAK1, PAK2, PALB2, PALLD, PAM, PAN2, PAN3, PANK1, PANK2, PANK3, PANK4, PAPOLA, PAPOLB, PAPOLG, PARD6A, PARD6B, PARD6G, PARG, PARK7, PARL, PARN, PARP1, PARP10, PARP11, PARP12, PARP14, PARP15, PARP2, PARP3, PARP4, PARP9, PARPBP, PARVA, PASD1, PASK, PATL1, PATL2, PATZ1, PAWR, PAX1, PAX2, PAX3, PAX4, PAX5, PAX6, PAX7, PAX8, PAX9, PAXBP1, PAXIP1, PAXX, PBK, PBOV1, PBRM1, PBX1, PBX2, PBX3, PBX4, PBXIP1, PCBD1, PCBD2, PCBP1, PCBP2, PCBP3, PCBP4, PCDHA2, PCF11, PCGF1, PCGF2, PCGF3, PCGF5, PCGF6, PCID2, PCIF1, PCLAF, PCM1, PCNA, PCNP, PCP4, PCYT1A, PDC, PDCD11, PDCD2, PDCD4, PDCD5, PDCD6, PDCD7, PDE2A, PDE4A, PDE4B, PDE4C, PDE4D, PDE4DIP, PDE7A, PDE7B, PDE8A, PDE8B, PDF, PDGFC, PDGFRA, PDGFRB, PDHA1, PDHA2, PDHB, PDIA3, PDIK1L, PDK1, PDLIM2, PDLIM4, PDPK1, PDS5A, PDS5B, PDX1, PDXK, PDZD2, PDZD7, PEBP1, PEG10, PEG3, PELI1, PELP1, PER1, PER2, PER3, PERM1, PES1, PEX14, PEX19, PFDN2, PFDN4, PFDN5, PFKM, PFKP, PFN1, PFN3, PGAM2, PGBD3, PGBD5, PGD, PGK2, PGR, PHACTR1, PHAX, PHB1, PHB2, PHC1, PHC2, PHC3, PHF1, PHF10, PHF11, PHF12, PHF13, PHF14, PHF19, PHF2, PHF20, PHF20L1, PHF21A, PHF23, PHF24, PHF3, PHF5A, PHF6, PHF7, PHF8, PHIP, PHLDA1, PHLPP1, PHOX2A, PHOX2B, PIAS1, PIAS2, PIAS3, PIAS4, PIBF1, PICALM, PIDD1, PIERCE1, PIF1, PIH1D1, PIK3C2A, PIK3C2B, PIK3CB, PIK3R1, PIK3R2, PIK3R5, PIM1, PIMREG, PIN1, PIN4, PINK1, PINX1, PIP, PIP4K2A, PIP4K2B, PIP5K1A, PIR, PISD, PITHD1, PITPNA, PITX1, PITX2, PITX3, PIWIL1, PIWIL2, PIWIL3, PIWIL4, PKD1, PKD2, PKHD1, PKIA, PKIB, PKIG, PKM, PKMYT1, PKN1, PKN2, PKN3, PKNOX1, PKNOX2, PKP1, PKP2, PKP3, PKP4, PLA2G4A, PLAA, PLAAT1, PLAG1, PLAGL1, PLAGL2, PLCB1, PLCB3, PLCB4, PLCD4, PLCXD2, PLCZ1, PLD4, PLD5P1, PLEKHA1, PLEKHA2, PLEKHA5, PLEKHF1, PLEKHG4B, PLEKHO1, PLIN2, PLK1, PLK2, PLK3, PLK4, PLRG1, PLSCR1, PLSCR3, PLTP, PMAIP1, PMCH, PMF1, PMF1-BGLAP, PML, PMP2, PMS1, PMS2, PNCK, PNKD, PNKP, PNLDC1, PNRC1, PNRC2, POGK, POGZ, POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLDIP2, POLDIP3, POLE, POLE2, POLE3, POLE4, POLH, POLI, POLK, POLL, POLM, POLN, POLQ, POLR1A, POLR1B, POLR1C, POLR1D, POLR1E, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2J2, POLR2J3, POLR2K, POLR2L, POLR2M, POLR3A, POLR3B, POLR3C, POLR3D, POLR3E, POLR3F, POLR3G, POLR3GL, POLR3H, POLR3K, POM121C, POMP, POP1, POP4, POP7, POT1, POU1F1, POU2AF1, POU2AF2, POU2AF3, POU2F1, POU2F2, POU2F3, POU3F1, POU3F3, POU3F4, POU4F1, POU4F2, POU4F3, POU5F1, POU5F1B, POU5F1P3, POU5F1P4, POU5F2, POU6F1, POU6F2, PPAN, PPARA, PPARD, PPARG, PPARGC1A, PPARGC1B, PPCS, PPEF1, PPEF2, PPHLN1, PPIA, PPIB, PPID, PPIE, PPIG, PPIL1, PPIL2, PPIL4, PPM1A, PPM1B, PPM1D, PPM1E, PPM1F, PPM1G, PPM1H, PPM1M, PPM1N, PPP1CA, PPP1CB, PPP1CC, PPP1R10, PPP1R11, PPP1R13B, PPP1R13L, PPP1R16B, PPP1R1B, PPP1R7, PPP1R8, PPP1R9B, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R3B, PPP2R3C, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, PPP3CA, PPP4C, PPP4R2, PPP4R3A, PPP4R3B, PPP5C, PPP6R1, PPP6R2, PPP6R3, PPRC1, PPT1, PPWD1, PQBP1, PRAC1, PRAC2, PRAG1, PRAME, PRC1, PRCC, PRDM1, PRDM10, PRDM11, PRDM12, PRDM13, PRDM14, PRDM15, PRDM16, PRDM2, PRDM4, PRDM5, PRDM6, PRDM7, PRDM8, PRDM9, PRDX1, PRDX4, PRDX5, PRDX6, PREB, PREP, PREPL, PRG1, PRG3, PRICKLE1, PRICKLE4, PRIMPOL, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKD1, PRKD2, PRKDC, PRKN, PRKRA, PRKRIP1, PRKX, PRL, PRM1, PRM2, PRM3, PRMT1, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT9, PROP1, PROX1, PROX2, PRP4K, PRPF18, PRPF19, PRPF3, PRPF31, PRPF38A, PRPF38B, PRPF39, PRPF4, PRPF6, PRPF8, PRR11, PRR12, PRR13, PRR14, PRR19, PRR7, PRRC2A, PRRX1, PRRX2, PRSS23, PRSS37, PRUNE1, PRX, PSEN1, PSIP1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMC1, PSMC2, PSMC3, PSMC3IP, PSMC4, PSMC5, PSMC6, PSMD1, PSMD10, PSMD11, PSMD13, PSMD14, PSMD2, PSMD3, PSMD4, PSMD7, PSMD8, PSMD9, PSME3, PSME3IP1, PSME4, PSMG1, PSMG2, PSPC1, PTBP1, PTBP2, PTBP3, PTEN, PTF1A, PTGES2, PTGES3, PTGES3L, PTGIS, PTH1R, PTHLH, PTK2, PTK2B, PTK6, PTMA, PTMAP7, PTMS, PTOV1, PTP4A1, PTP4A2, PTP4A3, PTPA, PTPMT1, PTPN11, PTPN12, PTPN13, PTPN14, PTPN18, PTPN2, PTPN20, PTPN22, PTPN23, PTPN6, PTPRE, PTPRN, PTTG1, PTTG1IP, PTTG2, PTTG3P, PTX3, PUF60, PURA, PURB, PURG, PUS1, PUS10, PUS3, PUS7, PUS7L, PWP1, PWWP2A, PWWP2B, PWWP3A, PXK, PXT1, PYCARD, PYDC1, PYDC2, PYGO1, PYGO2, PYROXD1, QKI, QRICH1, QRICH2, QTRT1, R3HDM2, R3HDM4, RAB2A, RAB34, RAB3IP, RAB6C, RABGAP1L, RABL6, RAC1, RAC3, RACGAP1, RACK1, RAD1, RAD17, RAD18, RAD21, RAD21L1, RAD23A, RAD23B, RAD50, RAD51, RAD51AP1, RAD51B, RAD51C, RAD51D, RAD52, RAD54B, RAD54L, RAD54L2, RAD9A, RAD9B, RAE1, RAF1, RAG1, RAG2, RAI1, RAI14, RAI2, RALBP1, RALGAPA1, RALGAPA2, RALGDS, RALY, RALYL, RAMAC, RAMACL, RAN, RANBP1, RANBP10, RANBP17, RANBP2, RANBP3, RANBP3L, RANBP6, RANBP9, RANGAP1, RANGRF, RAP1GDS1, RAPGEF5, RARA, RARB, RARG, RARS1, RASD1, RASSF1, RASSF2, RASSF5, RAVER1, RAVER2, RAX, RAX2, RB1, RB1CC1, RBAK, RBAK-RBAKDN, RBBP4, RBBP5, RBBP6, RBBP7, RBBP8, RBFOX1, RBFOX2, RBFOX3, RBKS, RBL1, RBL2, RBM10, RBM11, RBM12, RBM14, RBM15, RBM15B, RBM17, RBM20, RBM22, RBM23, RBM24, RBM26, RBM27, RBM28, RBM3, RBM33, RBM38, RBM39, RBM4, RBM42, RBM45, RBM46, RBM47, RBM5, RBM6, RBM7, RBM8A, RBMS1, RBMS2, RBMS3, RBMX, RBMX2, RBMXL1, RBMXL2, RBMXP1, RBMY1A1, RBMY1B, RBMY1C, RBMY1E, RBMY1F, RBP1, RBP2, RBP5, RBP7, RBPJ, RBPJL, RBPMS, RBPMS2, RBX1, RCAN1, RCAN2, RCAN3, RCBTB1, RCC1, RCC2, RCHY1, RCL1, RCOR1, RCOR2, RCOR3, RD3, RDH14, RDM1, REC8, RECQL, RECQL4, RECQL5, REEP6, REL, RELA, RELB, REPIN1, RER, RERE, RERG, RESF1, REST, REV1, REV3L, REXO1, REXO1L1P, REXO2, REXO4, REXO5, RFC1, RFC2, RFC3, RFC4, RFC5, RFPL1, RFPL3, RFPL4A, RFWD3, RFX2, RFX3, RFX4, RFX5, RFX6, RFX7, RFX8, RFXANK, RFXAP, RGCC, RGN, RGS10, RGS12, RGS13, RGS14, RGS17, RGS2, RGS20, RGS22, RGS3, RGS4, RGS6, RGS7BP, RGS8, RHNO1, RHOA, RHOB, RHOC, RHOXF1, RHOXF2, RHOXF2B, RIBC2, RIDA, RIF1, RILP, RIMBP3, RIMBP3B, RIMBP3C, RING1, RIOK2, RIOX1, RIOX2, RIPK3, RIPPLY1, RIPPLY2, RIPPLY3, RIT1, RIT2, RITA1, RLF, RLIM, RMDN3, RMI1, RMI2, RMND5A, RMND5B, RNASEH2A, RNASEH2B, RNASEH2C, RNF10, RNF11, RNF111, RNF112, RNF113A, RNF114, RNF115, RNF126, RNF138, RNF14, RNF146, RNF151, RNF168, RNF169, RNF17, RNF187, RNF2, RNF20, RNF212, RNF216, RNF220, RNF25, RNF34, RNF38, RNF4, RNF40, RNF6, RNF7, RNF8, RNGTT, RNH1, RNMT, RNPC3, RNPS1, ROCK2, ROPN1, RORA, RORB, RORC, RP1, RP9, RPA1, RPA2, RPA3, RPA4, RPAIN, RPAP1, RPAP2, RPE65, RPEL1, RPF1, RPL10, RPL10A, RPL10L, RPL13, RPL13A, RPL13AP3, RPL15, RPL17, RPL18, RPL22, RPL23A, RPL27, RPL3, RPL30, RPL36AL, RPL37A, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL9, RPLP0, RPP25L, RPP30, RPP40, RPRD1A, RPRD1B, RPS10, RPS10-NUDT3, RPS13, RPS15, RPS18, RPS2, RPS24, RPS25, RPS27, RPS27A, RPS27L, RPS3, RPS3A, RPS4Y1, RPS6, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RPS6KB1, RPS7, RPS8, RPS9, RPSA, RPSA2, RPUSD4, RRAGA, RRAGB, RRAGC, RRAGD, RREB1, RRM2, RRM2B, RRN3, RRN3P2, RRP1, RRP1B, RSBN1, RSBN1L, RSC1A1, RSF1, RSPH1, RSPO1, RSRC1, RSRP1, RTCA, RTCB, RTEL1, RTEL1-TNFRSF6B, RTF1, RTF2, RTKN2, RTL3, RTRAF, RUFY2, RUNX1, RUNX1T1, RUNX2, RUNX3, RUSC1, RUVBL1, RUVBL2, RWDD3, RXRA, RXRB, RXRG, RYBP, RYK, S100A1, S100A11, S100A12, S100A13, S100A16, S100A4, S100A5, S100A6, S100A7, S100A8, S100A9, S100B, S100P, S100PBP, SAAL1, SAC3D1, SACS, SAE1, SAFB, SAFB2, SAG, SALL1, SALL2, SALL3, SALL4, SAMD1, SAMD11, SAMD4B, SAMD7, SAMHD1, SAMSN1, SAP130, SAP18, SAP25, SAP30, SAP30BP, SAP30L, SAPCD2, SARNP, SARS1, SART1, SART3, SASH3, SATB1, SATB2, SAV1, SAXO2, SBDS, SBNO1, SBNO2, SCAF1, SCAF11, SCAF4, SCAF8, SCAI, SCAND1, SCAND2P, SCAND3, SCAPER, SCCPDH, SCG2, SCG5, SCGN, SCMH1, SCML1, SCML2, SCML4, SCNM1, SCP2, SCRN1, SCRT1, SCRT2, SCX, SCYL1, SDCBP, SDE2, SDR16C5, SDR39U1, SEBOX, SEC14L2, SELENBP1, SEM1, SEMG1, SEMG2, SENP1, SENP2, SENP3, SENP5, SENP6, SENP7, SEPSECS, SEPTIN12, SEPTIN2, SEPTIN4, SEPTIN7, SERBP1, SERF1A, SERF1B, SERF2, SERGEF, SERPINA3, SERPINB10, SERPINB3, SERPINB9, SERTAD1, SERTAD2, SERTAD3, SERTAD4, SESN1, SESN2, SESN3, SET, SETBP1, SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETDB1, SETDB2, SETDB2-PHF11, SETMAR, SETSIP, SETX, SF1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, SFMBT1, SFMBT2, SFN, SFPQ, SFR1, SFRP4, SFSWAP, SGF29, SGK1, SGK2, SGMS1, SGO1, SGO2, SGTA, SH2B1, SH3BGRL, SH3BGRL2, SH3BGRL3, SH3BP1, SH3BP4, SH3D19, SH3RF2, SHFL, SHISA5, SHLD2, SHMT1, SHMT2, SHOC2, SHOX, SHOX2, SHPRH, SIAH1, SIAH2, SIK1, SIK2, SIM1, SIM2, SIN3A, SIN3B, SINHCAF, SIPA1, SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, SIRT7, SIVA1, SIX1, SIX2, SIX3, SIX4, SIX5, SIX6, SKAP1, SKI, SKIC2, SKIC3, SKIC8, SKIL, SKOR1, SKOR2, SKP1, SKP2, SLBP, SLC11A2, SLC25A1, SLC25A10, SLC25A11, SLC25A19, SLC25A31, SLC25A42, SLC25A5, SLC25A6, SLC2A14, SLC2A4RG, SLC30A9, SLC39A11, SLC39A9, SLC4A1AP, SLC52A3, SLC5A5, SLC7A6OS, SLF1, SLF2, SLFN11, SLFN12, SLFN14, SLFN5, SLIRP, SLTM, SLU7, SLX1A, SLX1B, SLX4, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMAP1, SMAP2, SMARCA1, SMARCA2, SMARCA4, SMARCA5, SMARCAD1, SMARCAL1, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCD2, SMARCD3, SMARCE1, SMC1A, SMC1B, SMC2, SMC3, SMC4, SMC5, SMC6, SMCHD1, SMCR8, SMG1, SMG5, SMG6, SMG7, SMIM45, SMN1, SMN2, SMNDC1, SMO, SMOX, SMPX, SMTNL1, SMU1, SMUG1, SMURF2, SMYD1, SMYD2, SMYD3, SMYD4, SNAI1, SNAI2, SNAI3, SNAPC2, SNAPC3, SNAPC4, SNAPC5, SNCA, SND1, SNF8, SNIP1, SNRK, SNRNP200, SNRNP25, SNRNP27, SNRNP35, SNRNP40, SNRNP48, SNRNP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPGP15, SNRPN, SNTG1, SNU13, SNUPN, SNURF, SNW1, SNX10, SNX20, SNX6, SOBP, SOCS1, SOCS6, SOCS7, SOD1, SOHLH1, SOHLH2, SORBS1, SORBS2, SORBS3, SOX1, SOX10, SOX11, SOX12, SOX13, SOX14, SOX15, SOX17, SOX18, SOX2, SOX21, SOX3, SOX30, SOX4, SOX5, SOX6, SOX7, SOX8, SOX9, SP1, SP100, SP110, SP140, SP140L, SP3, SP4, SP5, SP6, SP7, SP8, SP9, SPACA9, SPACDR, SPAG6, SPAG7, SPAG8, SPANXA1, SPANXA2, SPANXB1, SPANXC, SPANXD, SPAST, SPATA2, SPATA24, SPATA31F1, SPATA31H1, SPATA33, SPATA4, SPC24, SPC25, SPDEF, SPDL1, SPDYA, SPDYC, SPECC1, SPEG, SPEN, SPG11, SPHK1, SPHK2, SPI1, SPIB, SPIC, SPIDR, SPIN1, SPIN2A, SPIN2B, SPIN4, SPINDOC, SPMAP2, SPMIP5, SPMIP6, SPMIP9, SPN, SPO11, SPOCD1, SPOP, SPOPL, SPRED1, SPRN, SPRTN, SPRY2, SPRYD4, SPSB3, SPTBN1, SPZ1, SQSTM1, SRA1, SRARP, SRC, SRCAP, SREBF1, SREBF2, SRF, SRFBP1, SRGAP2, SRP14, SRP54, SRPK1, SRPK2, SRPK3, SRRD, SRRM1, SRRM2, SRRM3, SRRM4, SRRT, SRSF1, SRSF10, SRSF11, SRSF12, SRSF2, SRSF3, SRSF4, SRSF6, SRSF7, SRSF8, SRSF9, SRY, SS18, SS18L1, SSB, SSBP1, SSBP2, SSBP3, SSBP4, SSH3, SSNA1, SSRP1, SSU72L1, SSU72L2, SSU72L3, SSU72L4, SSU72L5, SSU72L6, SSUH2, SSX1, SSX2, SSX2B, SSX2IP, SSX3, SSX4, SSX4B, SSX5, SSX6P, SSX7, SSX8P, SSX9P, ST18, STAG1, STAG2, STAG3, STAG3L1, STAG3L2, STAG3L3, STAMBP, STAP1, STARD9, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STC1, STEEP1, STH, STIMATE-MUSTN1, STIP1, STK11, STK17A, STK17B, STK19, STK24, STK3, STK33, STK35, STK36, STK38, STK39, STK4, STK40, STN1, STON1-GTF2A1L, STOX1, STOX2, STPG1, STPG4, STRA8, STRADA, STRADB, STRAP, STRBP, STRIP1, STRN3, STUB1, STX1B, STX3, STYX, SUB1, SUDS3, SUFU, SUGP1, SUGP2, SUGT1, SULT2B1, SUMO1, SUMO1P1, SUMO2, SUMO3, SUMO4, SUPT16H, SUPT20H, SUPT3H, SUPT4H1, SUPT5H, SUPT6H, SUPT7L, SUPV3L1, SUV39H1, SUV39H2, SUZ12, SVEP1, SVIL, SWAP70, SWI5, SWSAP1, SWT1, SYAP1, SYCE1, SYCE2, SYCE3, SYCP1, SYCP2, SYCP2L, SYCP3, SYF2, SYK, SYMPK, SYNCRIP, SYNE1, SYNE2, SYNPO, SYNPO2, SYNPO2L, TACC1, TACC2, TACSTD2, TADA1, TADA2A, TADA2B, TADA3, TAF1, TAF10, TAF11, TAF12, TAF13, TAF15, TAF1B, TAF1D, TAF1L, TAF2, TAF3, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF8, TAF9, TAF9B, TAFA2, TAGLN3, TAL1, TALDO1, TARBP1, TARBP2, TARDBP, TARS3, TASL, TASOR, TATDN1, TATDN2, TATDN3, TBC1D1, TBCB, TBL1X, TBL1XR1, TBL1Y, TBP, TBPL1, TBPL2, TBR1, TBRG1, TBX1, TBX10, TBX15, TBX18, TBX19, TBX2, TBX20, TBX21, TBX22, TBX3, TBX4, TBX5, TBX6, TBXT, TC2N, TCEA1, TCEA2, TCEA3, TCEAL1, TCEAL2, TCEAL3, TCEAL4, TCEAL5, TCEAL6, TCEAL7, TCEAL8, TCEAL9, TCEANC, TCEANC2, TCERG1, TCERG1L, TCF12, TCF15, TCF19, TCF20, TCF21, TCF23, TCF24, TCF25, TCF3, TCF4, TCF7, TCF7L1, TCF7L2, TCFL5, TCIM, TCIRG1, TCL1A, TCP10L, TCTN3, TDG, TDP1, TDP2, TDRD3, TDRD9, TDRP, TEAD1, TEAD2, TEAD3, TEAD4, TEC, TECR, TEF, TEKT1, TEKT2, TEKT3, TEKT4, TEKT5, TELO2, TEN1, TENM1, TENM2, TENM4, TENT2, TENT4A, TENT4B, TENT5B, TENT5C, TEP1, TERF1, TERF2, TERF2IP, TERT, TES, TESC, TESK1, TESK2, TESMIN, TET1, TET2, TET3, TEX10, TEX15, TEX19, TEX264, TEX35, TEX55, TFAM, TFAP2A, TFAP2B, TFAP2C, TFAP2D, TFAP2E, TFAP4, TFCP2, TFCP2L1, TFDP1, TFDP2, TFDP3, TFE3, TFEB, TFEC, TFIP11, TFPT, TGFB1, TGFBR1, TGIF1, TGIF2, TGIF2LX, TGIF2LY, TGM2, TGS1, TH, THAP1, THAP10, THAP11, THAP12, THAP2, THAP5, THAP7, THEMIS, THEMIS2, THOC1, THOC2, THOC3, THOC5, THOC6, THOC7, THRA, THRAP3, THRB, THRSP, THYN1, TIA1, TIAL1, TICRR, TIGAR, TIGD1, TIGD2, TIGD3, TIGD4, TIGD5, TIGD6, TIGD7, TIMELESS, TIMP3, TINF2, TIPARP, TIPIN, TJP1, TJP2, TJP3, TK1, TKFC, TLDC2, TLE1, TLE2, TLE3, TLE4, TLE5, TLE6, TLE7, TLK1, TLK2, TLX1, TLX2, TLX3, TMA16, TMBIM6, TMCO2, TMEM115, TMEM190, TMEM250, TMEM38B, TMEM43, TMEM53, TMEM89, TMEM8B, TMF1, TMPO, TMSB4X, TMUB1, TNFAIP1, TNFAIP3, TNFAIP8L2, TNIK, TNIP2, TNK2, TNKS, TNKS1BP1, TNKS2, TNNI2, TNNI3K, TNP1, TNP2, TNPO1, TNPO2, TNPO3, TOB1, TOB2, TOMM34, TONSL, TOP1, TOP2A, TOP2B, TOP3A, TOP3B, TOPBP1, TOPORS, TOR1A, TOR1AIP1, TOX, TOX2, TOX3, TOX4, TP53, TP53BP1, TP53BP2, TP53INP1, TP53INP2, TP53RK, TP53TG3, TP53TG3F, TP53TG5, TP63, TP73, TPI1, TPP1, TPP2, TPPP, TPR, TPRKB, TPRX1, TPRX2, TPRXL, TPT1, TPX2, TRA2A, TRA2B, TRADD, TRAF3IP2, TRAF4, TRAF6, TRAF7, TRAIP, TRAK1, TRAM1, TRAPPC12, TRAPPC2, TRAPPC2B, TRAPPC2L, TRDMT1, TRERF1, TREX1, TREX2, TRIAP1, TRIB1, TRIB2, TRIB3, TRIM11, TRIM14, TRIM15, TRIM21, TRIM22, TRIM23, TRIM24, TRIM25, TRIM26, TRIM27, TRIM28, TRIM32, TRIM33, TRIM35, TRIM39, TRIM41, TRIM45, TRIM47, TRIM5, TRIM52, TRIM55, TRIM63, TRIM66, TRIM68, TRIM69, TRIM7, TRIM8, TRIOBP, TRIP12, TRIP13, TRIP4, TRIP6, TRMT1, TRMT10A, TRMT10B, TRMT10C, TRMT1L, TRMT5, TRMT6, TRMT61A, TRMT9B, TRNAU1AP, TRNP1, TRNT1, TRO, TRPS1, TRRAP, TRUB1, TSBP1, TSC1, TSC2, TSC22D1, TSC22D3, TSC22D4, TSEN15, TSEN2, TSEN34, TSEN54, TSG101, TSHZ1, TSHZ2, TSHZ3, TSN, TSNAX, TSPY1, TSPY10, TSPY2, TSPY26P, TSPY3, TSPY4, TSPY8, TSPY9, TSPYL1, TSPYL2, TSPYL4, TSPYL5, TSPYL6, TSR1, TSR2, TSSC4, TSSK2, TSSK6, TTBK1, TTBK2, TTC3, TTC4, TTC5, TTF1, TTF2, TTI1, TTI2, TTK, TTLL12, TTLL5, TTN, TUB, TUBA1A, TUBA1C, TUBA3C, TUBA3E, TUBB, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBD1, TUBG1, TUBG2, TULP3, TUT4, TWIST1, TWIST2, TXK, TXN, TXNDC9, TXNL1, TXNL4A, TXNL4B, TXNRD1, TXNRD3, TYK2, TYMS, TYRO3, U2AF1, U2AF1L4, U2AF2, U2SURP, UACA, UBA1, UBA3, UBA5, UBA52, UBA7, UBAP2, UBAP2L, UBASH3B, UBB, UBC, UBD, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, UBE2F, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2K, UBE2L3, UBE2L5, UBE2L6, UBE2M, UBE2N, UBE2NL, UBE2O, UBE2Q1, UBE2Q2, UBE2QL1, UBE2S, UBE2T, UBE2V1, UBE2V2, UBE2W, UBE2Z, UBE3A, UBE3D, UBE4A, UBE4B, UBIAD1, UBL4A, UBL5, UBLCP1, UBN1, UBN2, UBOX5, UBP1, UBQLN1, UBQLN2, UBQLN4, UBR2, UBR4, UBR5, UBTF, UBTFL1, UBTFL6, UBXN1, UBXN2A, UBXN2B, UBXN6, UBXN7, UBXN8, UCHL5, UCKL1, UFD1, UFL1, UFM1, UFSP2, UGDH, UGP2, UHMK1, UHRF1, UHRF2, UIMC1, UMPS, UNC45A, UNCX, UNG, UNKL, UPF1, UPF2, UPF3A, UPF3B, UPRT, URGCP, URI1, URM1, USB1, USF1, USF2, USF3, USP1, USP10, USP11, USP12, USP13, USP15, USP16, USP17L1, USP17L10, USP17L11, USP17L12, USP17L13, USP17L15, USP17L17, USP17L18, USP17L19, USP17L2, USP17L20, USP17L21, USP17L22, USP17L23, USP17L24, USP17L3, USP17L30, USP17L4, USP17L5, USP17L6P, USP17L7, USP17L8, USP18, USP21, USP22, USP24, USP25, USP26, USP27X, USP28, USP29, USP3, USP30, USP31, USP34, USP35, USP36, USP37, USP38, USP39, USP4, USP40, USP42, USP44, USP45, USP46, USP47, USP48, USP49, USP5, USP50, USP51, USP7, USP8, USP9X, USP9Y, UTF1, UTP15, UTP18, UTP3, UTY, UXT, VAX1, VAX2, VBP1, VCP, VCPIP1, VCX, VCX3A, VCX3B, VDAC1, VDAC2, VDAC3, VDR, VEGFA, VENTX, VEZF1, VEZT, VGLL1, VGLL2, VGLL3, VGLL4, VHL, VIRMA, VPS25, VPS26C, VPS36, VPS4A, VPS4B, VPS72, VRK1, VRK2, VRK3, VRTN, VSX1, VSX2, VXN, WAC, WAPL, WARS1, WAS, WASL, WBP11, WBP2, WBP2NL, WBP4, WDFY1, WDR11, WDR13, WDR20, WDR26, WDR33, WDR37, WDR4, WDR43, WDR48, WDR5, WDR62, WDR70, WDR72, WDR74, WDR76, WDR77, WDR82, WDR83, WDTC1, WEE1, WEE2, WIZ, WNK1, WRN, WRNIP1, WT1, WTAP, WTIP, WWC1, WWOX, WWP1, WWP2, WWTR1, XAB2, XBP1, XIAP, XNDC1N, XNDC1N-ZNF705EP-ALG1L9P, XPA, XPC, XPO1, XPO4, XPO5, XPO6, XPO7, XPOT, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, XRCC6, XRN1, XRN2, XRRA1, YAE1, YAF2, YAP1, YARS1, YBEY, YBX1, YBX2, YBX3, YEATS2, YEATS4, YJU2, YJU2B, YLPM1, YPEL1, YPEL2, YPEL3, YPEL4, YPEL5, YTHDC1, YTHDF2, YWHAB, YWHAE, YWHAG, YWHAQ, YWHAZ, YY1, YY1AP1, YY2, ZBED1, ZBED2, ZBED4, ZBED6, ZBP1, ZBTB1, ZBTB10, ZBTB11, ZBTB12, ZBTB14, ZBTB16, ZBTB17, ZBTB18, ZBTB2, ZBTB20, ZBTB21, ZBTB22, ZBTB24, ZBTB25, ZBTB26, ZBTB3, ZBTB32, ZBTB33, ZBTB34, ZBTB37, ZBTB38, ZBTB39, ZBTB4, ZBTB40, ZBTB41, ZBTB42, ZBTB43, ZBTB44, ZBTB45, ZBTB46, ZBTB47, ZBTB48, ZBTB49, ZBTB5, ZBTB6, ZBTB7A, ZBTB7B, ZBTB7C, ZBTB8A, ZBTB8B, ZBTB8OS, ZBTB9, ZC3H10, ZC3H11A, ZC3H12A, ZC3H12B, ZC3H12C, ZC3H12D, ZC3H13, ZC3H14, ZC3H15, ZC3H18, ZC3H3, ZC3H4, ZC3H6, ZC3H7A, ZC3H7B, ZC3H8, ZC3HAV1, ZC3HC1, ZC4H2, ZCCHC12, ZCCHC18, ZCCHC4, ZCCHC7, ZCCHC8, ZCCHC9, ZCRB1, ZCWPW1, ZCWPW2, ZEB1, ZEB2, ZFAND2A, ZFAT, ZFC3H1, ZFHX2, ZFHX3, ZFHX4, ZFP1, ZFP14, ZFP2, ZFP28, ZFP3, ZFP30, ZFP36, ZFP36L1, ZFP36L2, ZFP37, ZFP41, ZFP42, ZFP57, ZFP62, ZFP64, ZFP69, ZFP69B, ZFP82, ZFP90, ZFP91, ZFP91-CNTF, ZFP92, ZFPL1, ZFPM1, ZFPM2, ZFR, ZFTA, ZFX, ZFY, ZGLP1, ZGPAT, ZGRF1, ZHX1, ZHX2, ZHX3, ZIC1, ZIC2, ZIC3, ZIC4, ZIC5, ZIK1, ZIM2, ZIM3, ZKSCAN1, ZKSCAN2, ZKSCAN3, ZKSCAN4, ZKSCAN5, ZKSCAN7, ZKSCAN8, ZMAT1, ZMAT2, ZMAT3, ZMAT4, ZMAT5, ZMIZ1, ZMIZ2, ZMYM1, ZMYM2, ZMYM3, ZMYM5, ZMYM6, ZMYND11, ZMYND15, ZMYND8, ZNF10, ZNF100, ZNF101, ZNF107, ZNF112, ZNF114, ZNF117, ZNF12, ZNF121, ZNF124, ZNF131, ZNF132, ZNF133, ZNF134, ZNF135, ZNF136, ZNF137P, ZNF138, ZNF14, ZNF140, ZNF141, ZNF142, ZNF143, ZNF146, ZNF148, ZNF154, ZNF155, ZNF157, ZNF16, ZNF160, ZNF165, ZNF169, ZNF17, ZNF174, ZNF175, ZNF177, ZNF18, ZNF180, ZNF181, ZNF182, ZNF184, ZNF189, ZNF19, ZNF195, ZNF197, ZNF2, ZNF20, ZNF200, ZNF202, ZNF205, ZNF207, ZNF208, ZNF211, ZNF212, ZNF213, ZNF214, ZNF215, ZNF217, ZNF219, ZNF22, ZNF221, ZNF222, ZNF223, ZNF224, ZNF225, ZNF226, ZNF227, ZNF229, ZNF23, ZNF230, ZNF232, ZNF233, ZNF234, ZNF235, ZNF236, ZNF239, ZNF24, ZNF248, ZNF25, ZNF250, ZNF251, ZNF253, ZNF254, ZNF256, ZNF257, ZNF26, ZNF260, ZNF263, ZNF264, ZNF266, ZNF267, ZNF268, ZNF273, ZNF274, ZNF275, ZNF276, ZNF277, ZNF28, ZNF280A, ZNF280B, ZNF280C, ZNF280D, ZNF281, ZNF282, ZNF283, ZNF284, ZNF285, ZNF286A, ZNF286B, ZNF287, ZNF292, ZNF296, ZNF3, ZNF30, ZNF300, ZNF302, ZNF304, ZNF311, ZNF316, ZNF317, ZNF318, ZNF319, ZNF32, ZNF320, ZNF322, ZNF324, ZNF324B, ZNF326, ZNF329, ZNF330, ZNF331, ZNF333, ZNF334, ZNF335, ZNF337, ZNF33A, ZNF33B, ZNF34, ZNF341, ZNF343, ZNF345, ZNF346, ZNF347, ZNF35, ZNF350, ZNF354A, ZNF354B, ZNF354C, ZNF355P, ZNF358, ZNF362, ZNF366, ZNF367, ZNF37A, ZNF382, ZNF383, ZNF384, ZNF385A, ZNF385B, ZNF385C, ZNF385D, ZNF391, ZNF394, ZNF395, ZNF396, ZNF397, ZNF398, ZNF404, ZNF407, ZNF408, ZNF41, ZNF410, ZNF414, ZNF415, ZNF416, ZNF417, ZNF418, ZNF419, ZNF420, ZNF423, ZNF425, ZNF426, ZNF429, ZNF43, ZNF430, ZNF431, ZNF432, ZNF433, ZNF436, ZNF438, ZNF439, ZNF44, ZNF440, ZNF441, ZNF442, ZNF443, ZNF444, ZNF445, ZNF446, ZNF449, ZNF451, ZNF454, ZNF460, ZNF461, ZNF462, ZNF467, ZNF468, ZNF469, ZNF470, ZNF471, ZNF473, ZNF475, ZNF479, ZNF48, ZNF480, ZNF483, ZNF484, ZNF485, ZNF486, ZNF487, ZNF488, ZNF490, ZNF491, ZNF492, ZNF493, ZNF496, ZNF497, ZNF500, ZNF501, ZNF502, ZNF503, ZNF506, ZNF507, ZNF510, ZNF511, ZNF512, ZNF512B, ZNF513, ZNF514, ZNF516, ZNF517, ZNF518A, ZNF518B, ZNF519, ZNF521, ZNF524, ZNF525, ZNF526, ZNF527, ZNF528, ZNF529, ZNF530, ZNF532, ZNF534, ZNF536, ZNF540, ZNF541, ZNF542P, ZNF543, ZNF544, ZNF546, ZNF547, ZNF548, ZNF549, ZNF550, ZNF551, ZNF552, ZNF554, ZNF555, ZNF556, ZNF557, ZNF558, ZNF559, ZNF559-ZNF177, ZNF560, ZNF561, ZNF562, ZNF563, ZNF564, ZNF565, ZNF566, ZNF567, ZNF568, ZNF569, ZNF57, ZNF570, ZNF571, ZNF572, ZNF573, ZNF574, ZNF575, ZNF576, ZNF577, ZNF578, ZNF579, ZNF580, ZNF581, ZNF582, ZNF583, ZNF584, ZNF585A, ZNF585B, ZNF586, ZNF587, ZNF587B, ZNF589, ZNF592, ZNF593, ZNF594, ZNF595, ZNF596, ZNF597, ZNF599, ZNF600, ZNF605, ZNF606, ZNF607, ZNF608, ZNF609, ZNF610, ZNF611, ZNF613, ZNF614, ZNF615, ZNF616, ZNF618, ZNF619, ZNF620, ZNF621, ZNF622, ZNF623, ZNF624, ZNF625, ZNF625-ZNF20, ZNF626, ZNF627, ZNF628, ZNF629, ZNF630, ZNF638, ZNF639, ZNF641, ZNF644, ZNF646, ZNF648, ZNF649, ZNF652, ZNF653, ZNF654, ZNF655, ZNF658, ZNF658B, ZNF66, ZNF660, ZNF662, ZNF664, ZNF665, ZNF667, ZNF668, ZNF669, ZNF670, ZNF671, ZNF672, ZNF674, ZNF675, ZNF676, ZNF677, ZNF678, ZNF679, ZNF680, ZNF681, ZNF682, ZNF683, ZNF684, ZNF687, ZNF688, ZNF689, ZNF69, ZNF691, ZNF692, ZNF695, ZNF696, ZNF697, ZNF699, ZNF7, ZNF70, ZNF700, ZNF701, ZNF702P, ZNF703, ZNF704, ZNF705A, ZNF705B, ZNF705D, ZNF705EP, ZNF705G, ZNF706, ZNF707, ZNF708, ZNF709, ZNF71, ZNF710, ZNF711, ZNF713, ZNF714, ZNF716, ZNF717, ZNF718, ZNF721, ZNF722, ZNF723, ZNF724, ZNF726, ZNF726P1, ZNF727, ZNF728, ZNF729, ZNF730, ZNF732, ZNF735, ZNF736, ZNF737, ZNF738, ZNF74, ZNF740, ZNF746, ZNF749, ZNF750, ZNF75A, ZNF75CP, ZNF75D, ZNF76, ZNF761, ZNF763, ZNF764, ZNF765, ZNF766, ZNF768, ZNF77, ZNF770, ZNF771, ZNF772, ZNF773, ZNF774, ZNF775, ZNF776, ZNF777, ZNF778, ZNF780A, ZNF780B, ZNF781, ZNF782, ZNF783, ZNF784, ZNF785, ZNF786, ZNF787, ZNF788P, ZNF789, ZNF79, ZNF790, ZNF791, ZNF792, ZNF793, ZNF799, ZNF8, ZNF80, ZNF800, ZNF804A, ZNF804B, ZNF805, ZNF808, ZNF81, ZNF813, ZNF814, ZNF816, ZNF818P, ZNF821, ZNF823, ZNF826P, ZNF827, ZNF829, ZNF83, ZNF830, ZNF833P, ZNF835, ZNF836, ZNF837, ZNF84, ZNF840P, ZNF841, ZNF844, ZNF845, ZNF846, ZNF85, ZNF850, ZNF852, ZNF860, ZNF862, ZNF865, ZNF875, ZNF876P, ZNF878, ZNF879, ZNF880, ZNF883, ZNF888, ZNF891, ZNF892, ZNF90, ZNF91, ZNF92, ZNF93, ZNF98, ZNF99, ZNG1A, ZNG1B, ZNG1C, ZNG1E, ZNG1F, ZNHIT1, ZNHIT3, ZNHIT6, ZPBP, ZPBP2, ZPR1, ZRANB1, ZRANB2, ZRANB3, ZRSR2, ZRSR2P1, ZSCAN1, ZSCAN10, ZSCAN12, ZSCAN16, ZSCAN18, ZSCAN2, ZSCAN20, ZSCAN21, ZSCAN22, ZSCAN23, ZSCAN25, ZSCAN26, ZSCAN29, ZSCAN30, ZSCAN31, ZSCAN32, ZSCAN4, ZSCAN5A, ZSCAN5B, ZSCAN5C, ZSCAN5DP, ZSCAN9, ZSWIM1, ZSWIM7, ZUP1, ZW10, ZWINT, ZXDA, ZXDB, ZXDC, ZYX, ZZZ3
ParishinB
Parishin B is a glycoside. Parishin B is a natural product found in Artemisia absinthium with data available. Parishin B, a parishin derivative isolated from Gastrodia elata, may have antioxidant property[1]. Parishin B, a parishin derivative isolated from Gastrodia elata, may have antioxidant property[1].
N-methylproline
N-Methyl-L-proline, also known as N-methyl-L-proline, (2S)-1-methylpyrrolidine-2-carboxylic acid, hydric acid, or monomethyl proline, is classified as a proline or a proline derivative. It is not naturally produced by humans and can only be obtained from the diet. In particular, it is a metabolically inert cell protectant found in many plants and is used by plants to protect against extremes in osmolarity and growth temperatures. N-Methyl-L-proline is found in the fruit juices of yellow orange, blood orange, lemon, mandarin, and bitter orange (PMID: 21838291). N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion. An L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. Hygric acid (N-Methyl-L-proline) is a proline analogue found in the citrus juices and the juice of bergamot[1].
DIMETHACHLOR
CONFIDENCE standard compound; EAWAG_UCHEM_ID 707 CONFIDENCE standard compound; INTERNAL_ID 8395 CONFIDENCE standard compound; INTERNAL_ID 3390
4-Sulfophenol
4-Hydroxybenzenesulfonic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=98-67-9 (retrieved 2024-08-06) (CAS RN: 98-67-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
RESORCINOL MONOACETATE
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent Same as: D02393
2,6-DICHLOROBENZAMIDE
A member of the class of benzamides that is benzamide substituted by chloro groups at positions 2 and 6. CONFIDENCE standard compound; EAWAG_UCHEM_ID 85 CONFIDENCE standard compound; INTERNAL_ID 3374 CONFIDENCE standard compound; INTERNAL_ID 4051 CONFIDENCE standard compound; INTERNAL_ID 8429
2-Naphthalenesulfonic acid
CONFIDENCE standard compound; INTERNAL_ID 1273; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3266; ORIGINAL_PRECURSOR_SCAN_NO 3264 CONFIDENCE standard compound; INTERNAL_ID 1273; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3270; ORIGINAL_PRECURSOR_SCAN_NO 3268 CONFIDENCE standard compound; INTERNAL_ID 1273; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3298; ORIGINAL_PRECURSOR_SCAN_NO 3294 CONFIDENCE standard compound; INTERNAL_ID 1273; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3290; ORIGINAL_PRECURSOR_SCAN_NO 3285 CONFIDENCE standard compound; INTERNAL_ID 1273; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3285; ORIGINAL_PRECURSOR_SCAN_NO 3282 CONFIDENCE standard compound; INTERNAL_ID 1273; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3292; ORIGINAL_PRECURSOR_SCAN_NO 3289 CONFIDENCE standard compound; INTERNAL_ID 626; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3356; ORIGINAL_PRECURSOR_SCAN_NO 3352 CONFIDENCE standard compound; INTERNAL_ID 626; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3363; ORIGINAL_PRECURSOR_SCAN_NO 3361 CONFIDENCE standard compound; INTERNAL_ID 626; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3353; ORIGINAL_PRECURSOR_SCAN_NO 3350 CONFIDENCE standard compound; INTERNAL_ID 626; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3351; ORIGINAL_PRECURSOR_SCAN_NO 3348 CONFIDENCE standard compound; INTERNAL_ID 626; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3344; ORIGINAL_PRECURSOR_SCAN_NO 3341 CONFIDENCE standard compound; INTERNAL_ID 626; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3371; ORIGINAL_PRECURSOR_SCAN_NO 3368 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 8811 CONFIDENCE standard compound; EAWAG_UCHEM_ID 653 CONFIDENCE standard compound; INTERNAL_ID 2300
3,5-Dibromo-4-hydroxybenzoate
CONFIDENCE standard compound; EAWAG_UCHEM_ID 804 EAWAG_UCHEM_ID 804; CONFIDENCE standard compound
Pyridazine-3,6-diol
D006133 - Growth Substances > D010937 - Plant Growth Regulators D010575 - Pesticides > D006540 - Herbicides D016573 - Agrochemicals
2-(1-Naphthyl)acetamide
Plant growth regulator. Plant growth regulator
pyrethrin I
D010575 - Pesticides > D007306 - Insecticides > D011722 - Pyrethrins
Carbinoxamine
Carbinoxamine, also known as carbinoxamine maleate or clistin, is a member of the class of compounds known as benzylethers. Benzylethers are aromatic ethers with the general formula ROCR (R = alkyl, aryl; R=benzene). Carbinoxamine is practically insoluble (in water) and a very strong basic compound (based on its pKa). Carbinoxamine can be found in barley and garden onion, which makes carbinoxamine a potential biomarker for the consumption of these food products. Carbinoxamine can be found primarily in blood and urine. In humans, carbinoxamine is involved in the carbinoxamine h1-antihistamine action. Carbinoxamine is a non-carcinogenic (not listed by IARC) potentially toxic compound. Carbinoxamine is a drug which is used for symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis, as well as allergic conjunctivitis caused by foods and inhaled allergens. also for the relief of allergic reactions to blood or plasma, and the symptomatic management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is approved by the U.S. Food and Drug Administration (FDA) (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine . Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamines anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown (DrugBank). Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamines anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown (T3DB). Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state do not use in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks. R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Benzoyl ecgonine
Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver. [Wikipedia] CONFIDENCE standard compound; INTERNAL_ID 1590
(R)-Sulcatol
(R)-Sulcatol is found in herbs and spices. (R)-Sulcatol occurs in lemongrass oi Flavouring ingredient. 6-Methyl-5-hepten-2-ol. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=4630-06-2 (retrieved 2024-07-12) (CAS RN: 1569-60-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Simetryn
CONFIDENCE standard compound; INTERNAL_ID 928; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7531; ORIGINAL_PRECURSOR_SCAN_NO 7528 CONFIDENCE standard compound; INTERNAL_ID 928; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7493; ORIGINAL_PRECURSOR_SCAN_NO 7491 CONFIDENCE standard compound; INTERNAL_ID 928; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7430; ORIGINAL_PRECURSOR_SCAN_NO 7428 CONFIDENCE standard compound; INTERNAL_ID 928; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7547; ORIGINAL_PRECURSOR_SCAN_NO 7544 CONFIDENCE standard compound; INTERNAL_ID 928; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7469; ORIGINAL_PRECURSOR_SCAN_NO 7467 CONFIDENCE standard compound; INTERNAL_ID 928; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7529; ORIGINAL_PRECURSOR_SCAN_NO 7525 CONFIDENCE standard compound; INTERNAL_ID 2605 CONFIDENCE standard compound; INTERNAL_ID 8404 CONFIDENCE standard compound; INTERNAL_ID 4021
16(R)-HETE
16(R)-HETE is a metabolite of arachidonic acid, metabolized by the enzyme Cytochrome P450, family 2, subfamily C [EC:1.14.13.80 1.14.13.48 1.14.13.49]. 16(R)-HETE is an endogenous lipidic inhibitor of human neutrophil inhibitor of adhesion and aggregation activity. Human polymorphonuclear leukocytes (PMNs) produce 16(R)-HETE that modulates their function. HETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli. Eicosanoids generated during the actions of growth factors and vasoconstrictors can modulate disease processes by affecting vascular homeostasis, inflammation, cellular growth, apoptosis and oxidant stress. In lung, the presence of these eicosanoids in the pulmonary vasculature and airways, including effects on pulmonary vascular and bronchial smooth muscle tone and airway epithelial ion transport. (PMID: 16258232, 14626496, 12681244, 11123211, 14552765, 11126912) [HMDB] 16(R)-HETE is a metabolite of arachidonic acid, metabolized by the enzyme Cytochrome P450, family 2, subfamily C [EC:1.14.13.80 1.14.13.48 1.14.13.49]. 16(R)-HETE is an endogenous lipidic inhibitor of human neutrophil inhibitor of adhesion and aggregation activity. Human polymorphonuclear leukocytes (PMNs) produce 16(R)-HETE that modulates their function. HETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli. Eicosanoids generated during the actions of growth factors and vasoconstrictors can modulate disease processes by affecting vascular homeostasis, inflammation, cellular growth, apoptosis and oxidant stress. In lung, the presence of these eicosanoids in the pulmonary vasculature and airways, including effects on pulmonary vascular and bronchial smooth muscle tone and airway epithelial ion transport. (PMID: 16258232, 14626496, 12681244, 11123211, 14552765, 11126912).
2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline is a metabolite of methadone. Methadone (also known as Symoron, Dolophine, Amidone, Methadose, Physeptone, Heptadon, Phy and many other names) is a synthetic opioid, used medically as an analgesic and a maintenance anti-addictive for use in patients with opioid dependency. It was developed in Germany in 1937. Although chemically unlike morphine or heroin, methadone acts on the same opioid receptors as these drugs, and thus has many of the same effects. (Wikipedia)
Ergosine
An ergot alkaloid isolated from the fungus Epichloe typhina. CONFIDENCE Claviceps purpurea sclerotia
3-Acetylmorphine
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
Bacitracin
Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesnt work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis. C254 - Anti-Infective Agent > C258 - Antibiotic > C295 - Bacitracin D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor[1][2][3].
Thiethylperazine
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AD - Phenothiazine derivatives D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent D005765 - Gastrointestinal Agents > D000932 - Antiemetics D002491 - Central Nervous System Agents Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
D-Chicoric acid
D-Chicoric acid is found in green vegetables. D-Chicoric acid is isolated from chicory (Cichorium intybus) and Cichorium endivia (endive). Isolated from chicory (Cichorium intybus) and Cichorium endivia (endive). D-Chicoric acid is found in green vegetables. Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3]. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].
Confertin
A natural product found in Inula hupehensis. A pseudoguaianolide that is decahydroazuleno[6,5-b]furan-2(3H)-one substituted by an oxo group at position 5, methyl groups at positions 4a and 8 and a methylidene group at position 3. It has been isolated from the aerial parts of Inula hupehensis.
Norselegiline
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
benz(a)acridine
CONFIDENCE standard compound; INTERNAL_ID 8030 CONFIDENCE standard compound; INTERNAL_ID 10
Dibenz[a,j]acridine
D009676 - Noxae > D002273 - Carcinogens CONFIDENCE standard compound; INTERNAL_ID 8309 CONFIDENCE standard compound; INTERNAL_ID 8180
1,2-CYCLOHEXANEDIOL
trans-Cyclohexane-1,2-diol is an endogenous metabolite.
2-(Methylamino)benzoic acid
2-(Methylamino)benzoic acid is found in citrus. 2-(Methylamino)benzoic acid is isolated from grapefruit peel oi KEIO_ID M127 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].
N-methyl-L-glutamic Acid
N-methyl-L-glutamic Acid, also known as N-Methylglutamate or (2S)-2-(methylamino)Pentanedioic acid, is classified as a glutamic acid or a Glutamic acid derivative. Glutamic acids are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. N-methyl-L-glutamic Acid is considered to be soluble (in water) and acidic KEIO_ID M067
Maleamic acid
A dicarboxylic acid monoamide of maleamic acid. (Z)-4-Amino-4-oxobut-2-enoic acid is an endogenous metabolite.
Phthalaldehydic acid
KEIO_ID C038 2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain[1].
9,10-Epoxyoctadecenoic acid
9,10-Epoxyoctadecenoic acid (9,10-EOA) is a peroxidation product of linoleic acid (LA). 9,10-EOA is a naturally occurring component of oxidized low density lipoprotein (LDL), the level of which increases with aging, atherosclerosis, and rheumatoid arthritis, perhaps due to an increase in 15-lipoxygenase and free oxygen radicals. 9,10-EOA is a proliferator-activated receptors (PPAR) gamma2 ligand, that is antiosteogenic without stimulating adipocyte differentiation. Studies in dogs suggest that 9,10-EOA has toxic cardiovascular effects. (PMID: 12665667, 12021203, 10667371).
xi-gamma-Undecalactone
(±)-5-Heptyldihydro-2(3H)-furanone is a flavouring ingredient. [Raw Data] CB092_gamma-Undecalactone_pos_20eV_CB000039.txt [Raw Data] CB092_gamma-Undecalactone_pos_30eV_CB000039.txt [Raw Data] CB092_gamma-Undecalactone_pos_10eV_CB000039.txt
8-methylthiooctyl glucosinolate
Acquisition and generation of the data is financially supported by the Max-Planck-Society
Glucoalyssin
A thia-glucosinolic acid that is glucoberteroin in which the sulfur atom of the methyl thioether group has been oxidised to the corresponding sulfoxide. Acquisition and generation of the data is financially supported by the Max-Planck-Society
8-Methylsulfinyloctyl glucosinolate
8-methylsulfinyloctyl glucosinolate is a member of the class of compounds known as alkylglucosinolates. Alkylglucosinolates are organic compounds containing a glucosinolate moiety that carries an alkyl chain. 8-methylsulfinyloctyl glucosinolate is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). 8-methylsulfinyloctyl glucosinolate can be found in a number of food items such as opium poppy, chinese chives, agave, and sparkleberry, which makes 8-methylsulfinyloctyl glucosinolate a potential biomarker for the consumption of these food products.
Cytidine 3'-monophosphate
Cytidine 3-monophosphate (3-CMP), also known as 3-cytidylic acid or 3-cytidylate, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. Cytidine 3-monophosphate has been identified in the human placenta (PMID: 32033212). Acquisition and generation of the data is financially supported in part by CREST/JST.
Desmethylxanthohumol
Desmethylxanthohumol is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2, 4, and 6 and a 3-methylbut-2-en-1-yl group at position 3. It has a role as a plant metabolite. It is a member of chalcones and a 2-acyl-4-prenylphloroglucinol. It is functionally related to a trans-chalcone. It is a conjugate acid of a desmethylxanthohumol(1-). Desmethylxanthohumol is a natural product found in Helichrysum dregeanum, Humulus lupulus, and other organisms with data available. A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2, 4, and 6 and a 3-methylbut-2-en-1-yl group at position 3. Desmethylxanthohumol is found in alcoholic beverages. Desmethylxanthohumol is a constituent of Humulus lupulus (hops) D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors D006133 - Growth Substances > D006131 - Growth Inhibitors
trans-cinnamoyl-beta-D-glucoside
Trans-cinnamoyl-beta-d-glucoside, also known as 1-O-trans-cinnamoyl-beta-D-glucopyranose, is a member of the class of compounds known as O-cinnamoyl glycosides. O-cinnamoyl glycosides are o-glycoside derivatives of cinnamic acid. Cinnamic acid is an aromatic compound containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. Trans-cinnamoyl-beta-d-glucoside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Trans-cinnamoyl-beta-d-glucoside can be found in a number of food items such as angelica, cherry tomato, garden cress, and yam, which makes trans-cinnamoyl-beta-d-glucoside a potential biomarker for the consumption of these food products. Trans-cinnamoyl-β-d-glucoside, also known as 1-O-trans-cinnamoyl-beta-D-glucopyranose, is a member of the class of compounds known as O-cinnamoyl glycosides. O-cinnamoyl glycosides are o-glycoside derivatives of cinnamic acid. Cinnamic acid is an aromatic compound containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. Trans-cinnamoyl-β-d-glucoside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Trans-cinnamoyl-β-d-glucoside can be found in a number of food items such as angelica, cherry tomato, garden cress, and yam, which makes trans-cinnamoyl-β-d-glucoside a potential biomarker for the consumption of these food products.
Archangelicin
Constituent of the roots of Angelica archangelica (anglica). Archangelicin is found in many foods, some of which are fats and oils, green vegetables, herbs and spices, and angelica. Archangelicin is found in angelica. Archangelicin is a constituent of the roots of Angelica archangelica (anglica)
4-Aminoisoxazolidin-3-one
4-amino-1,2-oxazolidin-3-one is a member of the class of oxazolidines that is isoxazoldin-3-one which is substituted at position 4 by an amino group. It is a serine derivative, a member of oxazolidines, a primary amino compound and a hydroxamic acid ester.
3-Hydroxy-N-(2-oxotetrahydrofuran-3-yl)octanamide
Aminoundecanoic acid
11-Aminoundecanoic acid is an organic compound with the formula H2N(CH2)10CO2H. This white solid is classified as an amine and a fatty acid. 11-Aminoundecanoic acid is a precursor to Nylon-11.[1] As practiced by Arkema, 11-aminoundecanoic acid is prepared industrially from undecylenic acid, which is derived from castor oil.[2] The synthesis proceeds in four separate reactions: 1. Transesterification of castor oil to methyl ricinoleate: Crude castor oil consists of about 80\\% triglycerides, from the ricinoleic acid, itself representing about 90\\% of the oil.[3] It is quantitatively transesterified with methanol to methyl ricinoleate (the methyl ester of ricinoleic acid) in the presence of the basic sodium methoxide at 80 °C within 1 h reaction time in a stirred reactor. At the end of the reaction, the resulting glycerol separates and the liquid methyl ester is washed with water to remove residual glycerol. 2. Pyrolysis of methylricinoleate to heptanal and methyl undecenoate: Methylricinoleate is evaporated at 250 °C, mixed with hot steam (600 °C) in a 1:1 ratio and decomposed in a cracking furnace at 400 - 575 °C at a retention time of about 10 seconds into its cleavage products heptanal and methyl undecenoate. The cleavage of the aliphatic chain occurs in this variant of the steam cracking selectively between the hydroxymethylene and the allyl-methylene group. Besides heptanal and methyl undecenoate, a mixture of methyl esters of saturated and unsaturated C18-carboxylic acids is obtained. This mixture is known under the trade name Esterol and is used as a lubricant additive. 3. Hydrolysis of methyl undecenoate to 10-undecenoic acid The hydrolysis of the methyl ester with sodium hydroxide proceeds at 25 °C within 30 min with quantitative yield. After acidification with hydrochloric acid, solid 10-undecenoic acid (undecylenic acid) is obtained. 4. Hydrobromination of 10-undecenoic acid to 11-bromoundecanoic acid The undecenoic acid is dissolved in toluene and, in the presence of the radical initiator benzoyl peroxide (BPO), gaseous hydrogen bromide is added, in contrary to the Markovnikov rule ("anti-Markovnikov"). When cooled to 0 °C, the fast and highly exothermic reaction produces 11-bromoundecanoic acid in 95\\% yield - the Markovnikov product 10-bromoundecanoic acid is produced in small quantities as a by-product. Toluene and unreacted hydrogen bromide are extracted under reduced pressure and reused. 5. Bromine exchange of 11-bromoundecanoic acid to 11-aminoundecanoic acid 11-Bromodecanoic acid is mixed at 30 °C with a large excess of 40\\% aqueous ammonia solution. When the reaction is complete, water is added and the mixture is heated to 100 °C to remove the excess ammonia. The acid can be recrystallized from water. For further purification, the hydrochloride of 11-aminoundecanoic acid, which is available by acidification with hydrochloric acid, can be recrystallized from a methanol/ethyl acetate mixture. Aminoundecanoic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=2432-99-7 (retrieved 2024-07-01) (CAS RN: 2432-99-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0). CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 1006
Nostoxanthin
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids Window width for selecting the precursor ion was 3 Da.; This record was created by the financial support of MEXT/JSPS KAKENHI Grant Number 16HP2005 to the Mass Spectrometry Society of Japan.
N1-trans-Feruloylagmatine
N1-trans-Feruloylagmatine is found in cereals and cereal products. N1-trans-Feruloylagmatine is isolated from Triticum aestivum (wheat) exposed to low temps. Isolated from Triticum aestivum (wheat) exposed to low temps. N1-trans-Feruloylagmatine is found in wheat and cereals and cereal products.
Leucyl-leucine
Leucylleucine is a dipeptide composed of two leucine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. Leu-Leu-OH, a Leu derivative, is a dipeptide.
1-O-Hexadecyl-sn-glycero-3-phosphocholine
Sinapoyl-CoA
The S-sinapoyl derivative of coenzyme A.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
streptidine
An amino cyclitol that is scyllo-inositol in which the hydroxy groups at positions 1 and 3 are replaced by guanidino groups.
2-Acetolactate
2-Acetolactate is involved in the butanoate metabolism and pantothenate and CoA biosynthesis pathways. In the butanoate metabolism pathway, 2-Acetolactate is created from 2-(alpha-Hydroxyethyl)thiamine diphosphate by acetolactate synthase [EC:2.2.1.6]. 2-Acetolactate is then converted to (R)-Acetoin by acetolactate decarboxylase [EC:4.1.1.5]. In the pantothenate and CoA pathway, 2-Acetolactate is irreversibly created from pyruvate by acetolactate synthase [EC:2.2.1.6]. 2-Acetolactate is then irreversibly converted to 2,3-Dihydroxy-3-methylbutanoate by ketol-acid reductoisomerase [EC:1.1.1.86]. 2-Acetolactate is involved in the butanoate metabolism and pantothenate and CoA biosynthesis pathways.
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
4-(2-Aminophenyl)-2,4-dioxobutanoic acid is a substrate for Kynurenine/alpha-aminoadipate aminotransferase mitochondrial. [HMDB] 4-(2-Aminophenyl)-2,4-dioxobutanoic acid is a substrate for Kynurenine/alpha-aminoadipate aminotransferase mitochondrial.
Cyanate
The cyanate ion is an anion consisting of one oxygen atom, one carbon atom, and one nitrogen atom, [OCN], in that order. The cyanate ion possesses 1 unit of negative charge, borne mainly by the nitrogen atom. In organic compounds the cyanate group is a functional group.; The cyanate ion is an ambident nucleophile in nucleophilic substitution because it can react to form an alkyl cyanate R-OCN (exception) or an alkyl isocyanate R-NCO (rule). Aryl cyanates (C6H5OCN) can be formed by a reaction of phenol with cyanogen chloride (ClCN) in the presence of a base. The cyanate ion is relatively non-toxic in comparison with cyanides. Use of this fact is made in cyanide decontamination processes where a permanganate oxidation converts toxic cyanide to safer cyanate. Cyanate can be decomposed by the enzyme cyanate lyase (or cyanase), which is found in bacteria and plants. In particular cyanate can be decomposed to carbamate (ammonia) and carbon dioxide. Alternately the same enzyme can be used to synthesize cyanate using carbamate and carbon dioxide. [HMDB] The cyanate ion is an anion consisting of one oxygen atom, one carbon atom, and one nitrogen atom, [OCN], in that order. The cyanate ion possesses 1 unit of negative charge, borne mainly by the nitrogen atom. In organic compounds the cyanate group is a functional group. The cyanate ion is an ambident nucleophile in nucleophilic substitution because it can react to form an alkyl cyanate R-OCN (exception) or an alkyl isocyanate R-NCO (rule). Aryl cyanates (C6H5OCN) can be formed by a reaction of phenol with cyanogen chloride (ClCN) in the presence of a base. The cyanate ion is relatively non-toxic in comparison with cyanides. Use of this fact is made in cyanide decontamination processes where a permanganate oxidation converts toxic cyanide to safer cyanate. Cyanate can be decomposed by the enzyme cyanate lyase (or cyanase), which is found in bacteria and plants. In particular cyanate can be decomposed to carbamate (ammonia) and carbon dioxide. Alternately the same enzyme can be used to synthesize cyanate using carbamate and carbon dioxide.
UDP-D-apiose
D-apiose is a plant-specific branched-chain monosaccharide found in rhamnogalacturonan II (RG-II), apiogalacturonan, and several apioglycosides. Within RG-II, d-apiose serves as the binding site for borate, which leads to the formation of cross-links within the wall. Biochemical studies in duckweed and parsley have established that uridine 5-diphospho-d-apiose (UDP-d-apiose) is formed from UDP-d-glucuronate by decarboxylation and re-arrangement of the carbon skeleton, leading to ring contraction and branch formation. The enzyme catalyzing this reaction also forms UDP-d-xylose by decarboxylation of UDP-d-glucuronate, and has therefore been named UDP-d-apiose/UDP-d-xylose synthase. (PMID: 12969423) [HMDB] D-Apiose is a plant-specific branched-chain monosaccharide found in rhamnogalacturonan II (RG-II), apiogalacturonan, and several apioglycosides. Within RG-II, D-apiose serves as the binding site for borate, which leads to the formation of cross-links within the wall. Biochemical studies in duckweed and parsley have established that uridine 5-diphospho-D-apiose (UDP-D-apiose) is formed from UDP-D-glucuronate by decarboxylation and re-arrangement of the carbon skeleton, leading to ring contraction and branch formation. The enzyme catalyzing this reaction also forms UDP-D-xylose by decarboxylation of UDP-D-glucuronate, and has therefore been named UDP-D-apiose/UDP-D-xylose synthase (PMID: 12969423).
Rifamycin O
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins
Gentamicin A
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D005839 - Gentamicins
Piperitenone
Piperitenone is a flavouring agent. It is found in grapefruit juice lemon juice, orange juice, spearmint oil and peppermint oil. It is also found in rosemary, mentha (mint), cornmint, and other herbs and spices. Piperitenone is found in citrus. Piperitenone is a flavouring agent. Piperitenone is present in grapefruit juice lemon juice, orange juice, spearmint oil and peppermint oi
Aristolochene
L-Erythrulose
L-Erythrulose is an extremely reactive ketose, which rapidly glycates and crosslinks proteins, and therefore may mediate the(L-ascorbate) AsA-dependent modification of protein (ascorbylation) seen in vitro, and also proposed to occur in vivo in human lens during diabetic and age-onset cataract formation.(PMID: 10727845) [HMDB] L-Erythrulose is an extremely reactive ketose, which rapidly glycates and crosslinks proteins, and therefore may mediate the(L-ascorbate) AsA-dependent modification of protein (ascorbylation) seen in vitro, and also proposed to occur in vivo in human lens during diabetic and age-onset cataract formation.(PMID: 10727845).
4-Hydroxy-3-methoxy-cinnamoylglycine
4-Hydroxy-3-methoxy-cinnamoylglycine belongs to the family of Acyl Glycines. These are organic compounds containing a glycine residue with the N-atom attached to another moiety through an N-ester bond
Chlordecone alcohol
Chlordecone alcohol is the major metabolite of Chlordecone [ an organochlorine pesticide, CAS# 143-50-0] in humans via bioreduction in the liver by Chlordecone reductase [EC: 1.1.1.225 ,CAS # 102484-73-1]. (PMID 2420999). Chlordecone treatment actively suppresses induction of 2B1 and 2B2 mRNAs in adult human hepatocytes; anti-estrogens such as Tamoxifen fail to reverse 2B1/2 mRNA induction following Chlordecone treatment of hepatocytes. (PMID 7513451). Both Chlordecone and Chlordecone alcohol alter the permeability of isolated ovine erythrocytes. (PMID 2455063). Chlordecone alcohol is the major metabolite of Chlordecone [ an organochlorine pesticide, CAS# 143-50-0] in humans via bioreduction in the liver by Chlordecone reductase [EC: 1.1.1.225 ,CAS # 102484-73-1]. (PMID 2420999)
4-hydroxybenzoyl-CoA
4-Hydroxybenzoyl-CoA is an intermediate in Fluorobenzoate degradation. 4-Hydroxybenzoyl-CoA is converted from 4-Fluorobenzoyl-CoA via the enzyme 4-chlorobenzoyl-CoA dehalogenase (EC 3.8.1.7). [HMDB]. 4-Hydroxybenzoyl-CoA is found in many foods, some of which are chinese chives, mustard spinach, salmonberry, and sunflower. 4-Hydroxybenzoyl-CoA is an intermediate in Fluorobenzoate degradation. 4-Hydroxybenzoyl-CoA is converted from 4-Fluorobenzoyl-CoA via the enzyme 4-chlorobenzoyl-CoA dehalogenase (EC 3.8.1.7). COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
10-Formyldihydrofolate
10-Formyldihydrofolate is a folate compound that has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells. The origin of 10-formyldihydrofolate remains an enigma. Its appearance only in the extracts from MTX-treated cells is not consistent with a simple oxidation of lO-formyl-H4folate during the extraction procedure. This, however, does not exclude the occurrence of spontaneous oxidation of 10-formyl-H4folate within the intact cells prior to the folate extraction. (PMID: 3366769) [HMDB] 10-formyldihydrofolate is a folate compound that has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells. The origin of 10-formyldihydrofolate remains an enigma. Its appearance only in the extracts from MTX-treated cells is not consistent with a simple oxidation of lO-formyl-H4folate during the extraction procedure. This, however, does not exclude the occurrence of spontaneous oxidation of 10-formyl-H4folate within the intact cells prior to the folate extraction. (PMID: 3366769).
Beta-D-Fructose 2-phosphate
beta-D-Fructose 2-phosphate is involved in the fructose eand mannose system. beta-D-Fructose 2-phosphate is produced from beta-D-Fructose 2,6-bisphosphate by the enzyme fructose-2,6-bisphosphate 6-phosphatase [EC 3.1.3.54]. [HMDB] beta-D-Fructose 2-phosphate is involved in the fructose eand mannose system. beta-D-Fructose 2-phosphate is produced from beta-D-Fructose 2,6-bisphosphate by the enzyme fructose-2,6-bisphosphate 6-phosphatase [EC 3.1.3.54].
2-Methylacetoacetyl-CoA
2-Methylacetoacetyl-CoA belongs to the class of organic compounds known as 3-oxo-acyl CoAs. These are organic compounds containing a 3-oxo acylated coenzyme A derivative. 2-Methylacetoacetyl-CoA is a substrate for 3-hydroxyacyl-CoA dehydrogenase type II, 3-ketoacyl-CoA thiolase (mitochondrial), peroxisomal bifunctional enzyme, trifunctional enzyme beta subunit (mitochondrial), short chain 3-hydroxyacyl-CoA dehydrogenase (mitochondrial), and 3-ketoacyl-CoA thiolase (peroxisomal). 2-Methylacetoacetyl-CoA is a substrate for 3-hydroxyacyl-CoA dehydrogenase type II, 3-ketoacyl-CoA thiolase (mitochondrial), Peroxisomal bifunctional enzyme, Trifunctional enzyme beta subunit (mitochondrial), Short chain 3-hydroxyacyl-CoA dehydrogenase (mitochondrial) and 3-ketoacyl-CoA thiolase (peroxisomal). [HMDB]. 2-Methylacetoacetyl-CoA is found in many foods, some of which are spirulina, macadamia nut (m. tetraphylla), root vegetables, and yardlong bean.
Prephytoene diphosphate
Phytoene is a precursor to carotenoids. Prephytoene comes from geranyl geranyl diphosphate (GGPP). Carotenoids are essential for life. Prephytoene diphosphate is involved in the following two reactions: 1) Prephytoene diphosphate + H+ + NADPH <=> Pyrophosphate + cis-Phytoene + NADP+ and 2) Geranylgeranyl diphosphate <=> Pyrophosphate + Prephytoene diphosphate + H+ [HMDB]. Prephytoene diphosphate is found in many foods, some of which are brassicas, wasabi, cocoa bean, and black elderberry. Phytoene is a precursor to carotenoids. Prephytoene comes from geranyl geranyl diphosphate (GGPP). Carotenoids are essential for life. Prephytoene diphosphate is involved in the following two reactions: 1) Prephytoene diphosphate + H+ + NADPH <=> Pyrophosphate + cis-Phytoene + NADP+ and 2) Geranylgeranyl diphosphate <=> Pyrophosphate + Prephytoene diphosphate + H+.
9-O-Acetylneuraminic acid
The acetate ester of the primary hydroxy group of neuraminic acid.
20-Hydroxy-leukotriene E4
20-Hydroxy-leukotriene E4 is a metabolite that can originate from the lipid oxidation of leukotriene E4 (LTE4). LTE4 is a cysteinyl leukotriene. Cysteinyl leukotrienes (CysLTs) are a family of potent inflammatory mediators that appear to contribute to the pathophysiologic features of allergic rhinitis. Nasal blockage induced by CysLTs is mainly due to dilatation of nasal blood vessels which can be induced by the nitric oxide produced through CysLT1 receptor activation. LTE4 activates contractile and inflammatory processes via specific interactions with putative seven transmembrane-spanning receptors that couple to G proteins and subsequent intracellular signaling pathways. LTE4 is metabolized from leukotriene C4 in a reaction catalyzed by gamma-glutamyl transpeptidase and a particulate dipeptidase from kidney (PMID: 12607939, 12432945, 6311078). Leukotrienes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent and are able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis through receptor-mediated G-protein linked signaling pathways.
8Z,11Z,14Z-eicosatrienoyl-CoA
8Z,11Z,14Z-eicosatrienoyl-CoA participates in the biosynthesis of unsaturated fatty acids. 8Z,11Z,14Z-eicosatrienoyl-CoA is converted from (8Z,11Z,14Z)-Icosatrienoic acid via palmitoyl-CoA hydrolase [EC:3.1.2.2].
Unsaturated fatty acids are of similar form, except that one or more alkenyl functional groups exist along the chain, with each alkene substituting a single-bonded "-CH2-CH2-" part of the chain with a double-bonded "-CH=CH-" portion (that is, a carbon double-bonded to another carbon). The differences in geometry between the various types of unsaturated fatty acids, as well as between saturated and unsaturated fatty acids, play an important role in biological processes, and in the construction of biological structures (such as cell membranes). (Wikipedia)
.8Z,11Z,14Z-eicosatrienoyl-CoA participates in the biosynthesis of unsaturated fatty acids. 8Z,11Z,14Z-eicosatrienoyl-CoA is converted from (8Z,11Z,14Z)-Icosatrienoic acid via palmitoyl-CoA hydrolase [EC:3.1.2.2].
4-Amino-3-hydroxybutyrate
4-Amino-3-hydroxybutyrate belongs to the class of organic compounds known as hydroxy fatty acids. These are fatty acids in which the chain bears a hydroxyl group.
CMP-N-glycoloylneuraminate
CMP-N-glycoloylneuraminate is an intermediate in Aminosugars metabolism. It is generated from CMP-N-acetylneuraminate via the enzyme CMP-N-acetylneuraminate monooxygenase (EC 1.14.18.2). CMP-N-glycoloylneuraminate can be converted to N-Glycolylneuraminate via the enzyme N-acylneuraminate cytidylyltransferase (EC 2.7.7.43). [HMDB] CMP-N-glycoloylneuraminate is an intermediate in Aminosugars metabolism. It is generated from CMP-N-acetylneuraminate via the enzyme CMP-N-acetylneuraminate monooxygenase (EC 1.14.18.2). CMP-N-glycoloylneuraminate can be converted to N-Glycolylneuraminate via the enzyme N-acylneuraminate cytidylyltransferase (EC 2.7.7.43).
5-Hydroxymethyldeoxycytidylate
(Z)-But-1-ene-1,2,4-tricarboxylate
This compound belongs to the family of Tricarboxylic Acids and Derivatives. These are organic compounds containing three carboxylic acid groups (or salt/ester derivatives thereof).
1-Piperideine-2-carboxylic acid
1-Piperideine-2-carboxylic acid (P2C), also known as Δ1-pipecolic acid, is classified as a member of the tetrahydropyridines. Tetrahydropyridines are derivatives of pyridine in which two double bonds in the pyridine moiety are reduced by adding four hydrogen atoms. 1-Piperideine-2-carboxylic acid is considered to be slightly soluble (in water) and acidic. 1-Piperideine-2-carboxylic acid is an intermediate of the L-lysine metabolic pathway in the brain; the uptake of P2C into the synaptosome of the cerebral cortex was Na+ and temperature-dependent (PMID: 7654748). delta 1-Piperidine-2-carboxylic acid (P2C), an intermediate of the L-lysine metabolic pathway in the brain; the uptake of P2C into the synaptosome of the cerebral cortex was Na+ and temperature-dependent (PMID 7654748 ) [HMDB]
SCHEMBL4290912
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D007210 - Indoleacetic Acids
6-Lactoyltetrahydropterin
6-Lactoyltetrahydropterin is a putative intermediate in the de novo synthesis of tetrahydrobiopterin (BH4) pathway, in a reaction involving the enzyme sepiapterin reductase (E.C. 1.1.1.153) in human liver. In brain, an enzyme distinct from sepiapterin reductase catalyzes the TPNH-dependent reduction of 6-pyruvoyl-tetrahydropterin to 6-lactoyl-tetrahydropterin. (PMID: 4004850). In brain, the expression of other enzymes involved in BH4 biosynthesis includes aldose reductase, carbonyl reductase, GTP-cyclohydrolase I, and 6-pyruvoyltetrahydrobiopterin. Sepiapterin reductase expression is increased in Parkinsons disease brain tissue. (PMID: 17270157). 6-Lactoyltetrahydropterin is a putative intermediate in the de novo synthesis of tetrahydrobiopterin (BH4) pathway, in a reaction involving the enzyme sepiapterin reductase (E.C. 1.1.1.153) in human liver. In brain, an enzyme distinct from sepiapterin reductase catalyzes the TPNH-dependent reduction of 6-pyruvoyl-tetrahydropterin to 6-lactoyl-tetrahydropterin. (PMID: 4004850)
3-deoxy-D-manno-octulosonate 8-phosphate
3-deoxy-d-manno-octulosonate 8-phosphate is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 3-deoxy-d-manno-octulosonate 8-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). 3-deoxy-d-manno-octulosonate 8-phosphate can be found in a number of food items such as green zucchini, okra, nopal, and grape, which makes 3-deoxy-d-manno-octulosonate 8-phosphate a potential biomarker for the consumption of these food products.
juvenile hormone III
Phosphoribulosylformimino-AICAR-P
Phosphoribulosylformimino-AICAR-P belongs to the class of organic compounds known as 1-ribosyl-imidazolecarboxamides. These are organic compounds containing the imidazole ring linked to a ribose ring through a 1-2 bond. Phosphoribulosylformimino-AICAR-P is a strong basic compound (based on its pKa). Phosphoribulosylformimino-AICAR-P is found in both E. coli and humans. A human metabolite taken as a putative food compound of mammalian origin [HMDB]
Histidylleucine
Histidylleucine is a dipeptide composed of histidine and leucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
3-ureido-isobutyrate
Ureidoisobutyric acid, also known as 3-ureidoisobutyrate or beta-uba, is a member of the class of compounds known as ureas. Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group. Ureidoisobutyric acid is soluble (in water) and a weakly acidic compound (based on its pKa). Ureidoisobutyric acid can be found in a number of food items such as pili nut, breakfast cereal, bitter gourd, and scarlet bean, which makes ureidoisobutyric acid a potential biomarker for the consumption of these food products. Ureidoisobutyric acid can be found primarily in blood, cerebrospinal fluid (CSF), and urine. Ureidoisobutyric acid exists in all living organisms, ranging from bacteria to humans. In humans, ureidoisobutyric acid is involved in the pyrimidine metabolism. Ureidoisobutyric acid is also involved in few metabolic disorders, which include beta ureidopropionase deficiency, dihydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and UMP synthase deficiency (orotic aciduria). Moreover, ureidoisobutyric acid is found to be associated with beta-ureidopropionase deficiency.
3-Oxohexadecanoyl-CoA
3-Oxohexadecanoyl-CoA has a role in the synthesis and oxidation of fatty acid. It is involved in the pathway, fatty acid elongation in mitochondria. In this pathway Acetyl-CoA is acted upon by the enzyme, acetyl-CoA C-acyltransferase to produce 3-Oxohexadecanoyl-CoA. Since coenzyme A is chemically a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. It assists in transferring fatty acids from the cytoplasm to the mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group it is usually referred to as CoASH or HSCoA. [HMDB] 3-Oxohexadecanoyl-CoA has a role in the synthesis and oxidation of fatty acid. It is involved in the pathway, fatty acid elongation in mitochondria. In this pathway Acetyl-CoA is acted upon by the enzyme, acetyl-CoA C-acyltransferase to produce 3-Oxohexadecanoyl-CoA. Since coenzyme A is chemically a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. It assists in transferring fatty acids from the cytoplasm to the mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group it is usually referred to as CoASH or HSCoA.
(S)-Hydroxydecanoyl-CoA
(s)-hydroxydecanoyl-coa, also known as S-(3-hydroxydecanoate) CoA or 3S-hydroxy-decanoyl-CoA is an acyl-CoA or acyl-coenzyme A. More specifically, it is a 3-hydroxydecanoic acid thioester of coenzyme A. (s)-hydroxydecanoyl-coa is an acyl-CoA with 10 fatty acid group as the acyl moiety attached to coenzyme A. Coenzyme A was discovered in 1946 by Fritz Lipmann (Journal of Biological Chemistry (1946) 162 (3): 743–744) and its structure was determined in the early 1950s at the Lister Institute in London. Coenzyme A is a complex, thiol-containing molecule that is naturally synthesized from pantothenate (vitamin B5), which is found in various foods such as meat, vegetables, cereal grains, legumes, eggs, and milk. More specifically, coenzyme A (CoASH or CoA) consists of a beta-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3-phosphorylated ADP. Coenzyme A is synthesized in a five-step process that requires four molecules of ATP, pantothenate and cysteine. It is believed that there are more than 1100 types of acyl-CoA’s in the human body, which also corresponds to the number of acylcarnitines in the human body. Acyl-CoAs exists in all living species, ranging from bacteria to plants to humans. The general role of acyl-CoA’s is to assist in transferring fatty acids from the cytoplasm to mitochondria. This process facilitates the production of fatty acids in cells, which are essential in cell membrane structure. Acyl-CoAs are also susceptible to beta oxidation, forming, ultimately, acetyl-CoA. Acetyl-CoA can enter the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP -- or biochemical energy. Acyl-CoAs can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain acyl-CoAs; 2) medium-chain acyl-CoAs; 3) long-chain acyl-CoAs; and 4) very long-chain acyl-CoAs; 5) hydroxy acyl-CoAs; 6) branched chain acyl-CoAs; 7) unsaturated acyl-CoAs; 8) dicarboxylic acyl-CoAs and 9) miscellaneous acyl-CoAs. Short-chain acyl-CoAs have acyl-groups with two to four carbons (C2-C4), medium-chain acyl-CoAs have acyl-groups with five to eleven carbons (C5-C11), long-chain acyl-CoAs have acyl-groups with twelve to twenty carbons (C12-C20) while very long-chain acyl-CoAs have acyl groups with more than 20 carbons. (s)-hydroxydecanoyl-coa is therefore classified as a medium chain acyl-CoA. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase/synthase. Fatty acids are first converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase. Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. (s)-hydroxydecanoyl-coa, being a medium chain acyl-CoA is a substrate for medium chain acyl-CoA synthase. The second step of fatty acid degradation is beta oxidation. Beta oxidation occurs in mitochondria and, in the case of very long chain acyl-CoAs, the peroxisome. After its formation in the cytosol, (S)-Hydroxydecanoyl-CoA is transported into the mitochondria, the locus of beta oxidation. Transport of (S)-Hydroxydecanoyl-CoA into the mitochondria requires carnitine palmitoyltransferase 1 (CPT1), which converts (S)-Hydroxydecanoyl-CoA into 3-Hydroxydecanoylcarnitine, which gets transported into the mitochondrial matrix. Once in the matrix, 3-Hydroxydecanoylcarnitine is converted back to (S)-Hydroxydecanoyl-CoA by CPT2, whereupon beta-oxidation can begin. Beta oxidation of (S)-Hydroxydecanoyl-CoA occurs in four steps. First, since (S)-Hydroxydecanoyl-CoA is a medium chain acyl-CoA it is the substrate for a medium chain acyl-CoA dehydrogenase, which catalyzes dehydrogenation of (S)-Hydroxydecanoyl-CoA, creating a double bond between the alpha and beta carbons. FAD is the hydrogen acceptor, yielding FADH2. Second, Enoyl-CoA hydrase catalyzes the addition of water across the newly formed double bo... (S)-Hydroxydecanoyl-CoA has a role in the synthesis and oxidation of fatty acids. It is involved in fatty acid elongation in mitochondria. In this pathway 3-Oxodecanoyl-CoA is acted upon by two enzymes, 3-hydroxyacyl-CoA dehydrogenase and long-chain-3-hydroxyacyl-CoA dehydrogenase to produce (S)-Hydroxydecanoyl-CoA. Since coenzyme A is chemically a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. It assists in transferring fatty acids from the cytoplasm to mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group it is usually referred to as CoASH or HSCoA. [HMDB]
19-Oxoandrost-4-ene-3,17-dione
19-Oxoandrost-4-ene-3,17-dione is an intermediate in Androgen and estrogen metabolism. 19-Oxoandrost-4-ene-3,17-dione is the 4th to last step in the synthesis of 2-Methoxyestrone 3-glucuronide. It is generated from 19-Hydroxyandrost-4-ene-3,17-dione and then converted to Estrone. [HMDB] 19-Oxoandrost-4-ene-3,17-dione is an intermediate in Androgen and estrogen metabolism. 19-Oxoandrost-4-ene-3,17-dione is the 4th to last step in the synthesis of 2-Methoxyestrone 3-glucuronide. It is generated from 19-Hydroxyandrost-4-ene-3,17-dione and then converted to Estrone. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Ergosta-5,7,22,24(28)-tetraen-3beta-ol
A 3beta-sterol having double bonds in the 5-, 7- and 22-positions and a methylene group at position 24.
20a,22b-Dihydroxycholesterol
20alpha,22beta-Dihydroxycholesterol is an intermediate in C21-Steroid hormone metabolism. 20alpha,22beta-Dihydroxycholesterol is the 8th to last step in the synthesis of 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al and is converted from 20alpha-Hydroxycholesterol via the enzyme cytochrome P450 (EC 1.14.15.6). It is then converted to Pregnenolone via the enzyme cytochrome P450 (EC 1.14.15.6). [HMDB] 20alpha,22beta-Dihydroxycholesterol is an intermediate in C21-Steroid hormone metabolism. 20alpha,22beta-Dihydroxycholesterol is the 8th to last step in the synthesis of 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al and is converted from 20alpha-Hydroxycholesterol via the enzyme cytochrome P450 (EC 1.14.15.6). It is then converted to Pregnenolone via the enzyme cytochrome P450 (EC 1.14.15.6).
3-Sulfopyruvic acid
Sulfopyruvate, also known as 2-carboxy-2-oxoethanesulfonic acid or beta-sulfopyruvic acid, belongs to alpha-keto acids and derivatives class of compounds. Those are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon. Sulfopyruvate is soluble (in water) and an extremely strong acidic compound (based on its pKa). Sulfopyruvate can be found in a number of food items such as french plantain, sago palm, sweet cherry, and ostrich fern, which makes sulfopyruvate a potential biomarker for the consumption of these food products. Sulfopyruvate exists in all living organisms, ranging from bacteria to humans. 3-Sulfopyruvic acid is the product of the transamination of cysteinesulfonate in a reaction catalyzed by aspartate aminotransferase. 3-sulfopyruvic acid is stable and is reduced by malate dehydrogenase to beta-sulfolactate, which is excreted in the urine. Cysteinesulfonate, 3-sulfopyruvic acid, and beta-sulfolactate are reversibly interconverted in vivo. (PMID: 3346220).
3-Methoxy-4-hydroxyphenylglycolaldehyde
3-Methoxy-4-hydroxyphenylglycolaldehyde is the monoamine oxidase (MAO) aldehyde metabolite of metanephrine. Metanephrine is an O-methylated metabolite formed by catechol-O-methyltransferase (COMT) from epinephrine. Catecholamines play an important role in platelet activation and aggregation, epinephrine being the most potent one. Catecholamines are substantially increased during stress, exercise or smoking and could result in clinically important platelet activation if their action was not rapidly regulated. The inhibitory effects of methoxy phenolic derivatives on epinephrine-induced platelet aggregation may possibly be attributed to their free radical scavenging properties. There is substantial evidence to conclude that an internal rapid autoregulation of epinephrine-induced platelet aggregation, caused by its metabolic degradation products, takes place in vivo. (PMID: 11958479, 9706478) [HMDB]. 3-Methoxy-4-hydroxyphenylglycolaldehyde is found in many foods, some of which are nutmeg, peach (variety), common oregano, and olive. 3-Methoxy-4-hydroxyphenylglycolaldehyde is the monoamine oxidase (MAO) aldehyde metabolite of metanephrine. Metanephrine is an O-methylated metabolite formed by catechol-O-methyltransferase (COMT) from epinephrine. Catecholamines play an important role in platelet activation and aggregation, epinephrine being the most potent one. Catecholamines are substantially increased during stress, exercise or smoking and could result in clinically important platelet activation if their action was not rapidly regulated. The inhibitory effects of methoxy phenolic derivatives on epinephrine-induced platelet aggregation may possibly be attributed to their free radical scavenging properties. There is substantial evidence to conclude that an internal rapid autoregulation of epinephrine-induced platelet aggregation, caused by its metabolic degradation products, takes place in vivo. (PMID: 11958479, 9706478).
N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole
N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole is an intermediate in riboflavin metabolism. It is converted from N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole via dephosphorylation by the enzyme phosphohistidine phosphatase 1 (EC 3.1.3.-). Humans do not have all the enzymes needed to synthesize or metabolize riboflavin. However, gut microflora do have the necessary enzymatic machinery to produce and metabolize this vitamin. Riboflavin (or vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and animals. It is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. Riboflavin is yellow or yellow-orange in color and in addition to being used as a food coloring it is also used to fortify some foods including baby foods, breakfast cereals, pastas, sauces, processed cheese, fruit drinks, vitamin-enriched milk products, some energy drinks, and vitamin supplements. [HMDB] N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole is an intermediate in riboflavin metabolism. It is converted from N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole via dephosphorylation by the enzyme phosphohistidine phosphatase 1 (EC 3.1.3.-). Humans do not have all the enzymes needed to synthesize or metabolize riboflavin. However, gut microflora do have the necessary enzymatic machinery to produce and metabolize this vitamin. Riboflavin (or vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and animals. It is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. Riboflavin is yellow or yellow-orange in color and in addition to being used as a food coloring it is also used to fortify some foods including baby foods, breakfast cereals, pastas, sauces, processed cheese, fruit drinks, vitamin-enriched milk products, some energy drinks, and vitamin supplements.
2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone is involved in the ubiquinone biosynthesis pathway. 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone is created from 2-Hexaprenyl-6-methoxy-1,4-benzoquinone by ubiquinone biosynthesis methyltransferase [EC:2.1.1.-]. 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone is then converted to 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone by ubiquinone biosynthesis monooxygenase Coq7 [EC:1.14.13.-]. [HMDB] 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone is involved in the ubiquinone biosynthesis pathway. 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone is created from 2-Hexaprenyl-6-methoxy-1,4-benzoquinone by ubiquinone biosynthesis methyltransferase [EC:2.1.1.-]. 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone is then converted to 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone by ubiquinone biosynthesis monooxygenase Coq7 [EC:1.14.13.-].
3-Mercaptolactic acid
3-Mercaptolactic acid is a thiol that has been confirmed to be found in urine (PMID 8852041). [HMDB] 3-Mercaptolactic acid is a thiol that has been confirmed to be found in urine (PMID 8852041).
Vitamin A2 aldehyde
Vitamin A2 aldehyde is found in fishes. Vitamin A2 aldehyde is a constituent fish of liver oils D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids Constituent fish of liver oils. Vitamin A2 aldehyde is found in fishes.
Acetyl adenylate
Acetyl adenylate is an intermediate in acetyl-CoA synthesis. It is converted from acetate via the enzyme acetyl-CoA synthetase. It is involved in the non-enzymatic acetylation of histones in chromatin (PMID:8619849). In microbes acetyl adenylate also plays a role in the direction of flagellar rotation (PMID:2901103) [HMDB] Acetyl adenylate is an intermediate in acetyl-CoA synthesis. It is converted from acetate via the enzyme acetyl-CoA synthetase. It is involved in the non-enzymatic acetylation of histones in chromatin (PMID:8619849). In microbes acetyl adenylate also plays a role in the direction of flagellar rotation (PMID:2901103).
Hygrine
Hygrine, also known as (+)-hygrine or (+)-N-methyl-2-acetonylpyrrolidine, belongs to alkaloids and derivatives class of compounds. Those are naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic propertiesand is also some synthetic compounds of similar structure are attributed to alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and more rarely other elements such as chlorine, bromine, and phosphorus. Hygrine is soluble (in water) and an extremely weak acidic compound (based on its pKa). Hygrine can be found in pomegranate, which makes hygrine a potential biomarker for the consumption of this food product. Hygrine is a pyrrolidine alkaloid, found mainly in coca leaves (0.2\\%). It was first isolated by Carl Liebermann in 1889 (along with a related compound cuscohygrine) as an alkaloid accompanying cocaine in coca. Hygrine is extracted as a thick yellow oil, having a pungent taste and odor .
Benzoyl phosphate
This compound belongs to the family of Benzoic Acid and Derivatives. These are organic compounds containing a carboxylic acid substituent attached to a benzene ring
N-Acetylneuraminate 9-phosphate
N-Acetylneuraminate 9-phosphate is an intermediate in Aminosugars metabolism. N-Acetylneuraminate 9-phosphate is the 4th to last step in the synthesis of colominate and is converted from N-Acetyl-D-mannosamine-6-phosphate via the enzyme N-Acylneuraminate-9-phosphate synthase (EC 2.5.1.57). It is then converted to N-Acetylneuraminate via the enzyme N-acylneuraminate-9-phosphatase(EC 3.1.3.29). [HMDB] N-Acetylneuraminate 9-phosphate is an intermediate in Aminosugars metabolism. N-Acetylneuraminate 9-phosphate is the 4th to last step in the synthesis of colominate and is converted from N-Acetyl-D-mannosamine-6-phosphate via the enzyme N-Acylneuraminate-9-phosphate synthase (EC 2.5.1.57). It is then converted to N-Acetylneuraminate via the enzyme N-acylneuraminate-9-phosphatase(EC 3.1.3.29).
1-Deoxy-D-xylulose
1-Deoxy-D-xylulose is a product of the splitting up of Pyridoxine (an intermediate in Vitamin B6 metabolism) into two components (the other one being 4-Hydroxy-L-threonine). (KEGG) [HMDB] 1-Deoxy-D-xylulose is a product of the splitting up of Pyridoxine (an intermediate in Vitamin B6 metabolism) into two components (the other one being 4-Hydroxy-L-threonine). (KEGG).
2,5-dichloro-2,5-cyclohexadiene-1,4-diol
A cyclohexadienediol that is cyclohexa-2,5-diene-1,4-diol in which positions 2 and 5 are substituted by chlorines.
Protoanemonin
Protoanemonin (sometimes called anemonol or ranunculol) is a toxin found in all plants of the buttercup family (Ranunculaceae). On maceration, for example when the plant is wounded, it is produced by an enzymatic process from the glucoside ranunculin. It is the lactone of 4-hydroxy-2,4-pentadienoic acid. A wounded plant releases the substance, causing itch, rashes or blistering on contact with the skin or mucosa. (Wikipedia)
dimethisterone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
Benzthiazide
Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
Phenindamine
Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. It is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold. Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures. R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D-glycero-D-manno-Heptose 1-phosphate
Ethotoin
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AB - Hydantoin derivatives C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants D049990 - Membrane Transport Modulators
2-Hydroxy-6-oxo-(2-aminophenyl)-hexa-2,4-dienoate
Thial-1-Propene-1-thiol S-oxide
Lachrymatory factor of onion (Allium cepa). Thial-1-Propene-1-thiol S-oxide is found in garden onion and onion-family vegetables. Thial-1-Propene-1-thiol S-oxide is found in garden onion. Lachrymatory factor of onion (Allium cepa).
Falcarinone
Isolated from Sium sisarum (skirret). Falcarinone is found in many foods, some of which are parsley, green vegetables, caraway, and coffee and coffee products. Falcarinone is found in caraway. Falcarinone is isolated from Sium sisarum (skirret).
Cucumopine
Cucumopine, also known as mikimopine or cucumopine, (4r-cis)-isomer, is a member of the class of compounds known as L-alpha-amino acids. L-alpha-amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. Cucumopine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Cucumopine can be found in carrot and wild carrot, which makes cucumopine a potential biomarker for the consumption of these food products.
Rhazin
Akuammidine is a natural product found in Aspidosperma quebracho-blanco, Tabernaemontana citrifolia, and other organisms with data available.
tinyatoxin
A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C36H38O8. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).
Pollinastanol
Pollinastanol is found in dandelion. Pollinastanol is isolated from Smilax medica (Sarsaparilla
Isogentisin
Isogentisin is found in alcoholic beverages. Isogentisin is isolated from roots of Gentiana lutea (yellow gentian
Mesuaxanthone B
A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 5 and 6.
2-(3,4-Dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-1-benzopyran-4-one
Pedalitin is a tetrahydroxy-monohydroxy-flavone, with the four hydroxy groups at C-3,-4,-5 and 6, and the methoxy group at C-7. It has been isolated from a number of plant species, including Eremosparton songoricum, Rabdosia japonica and Ruellia tuberosa. It has a role as an EC 1.17.3.2 (xanthine oxidase) inhibitor and a metabolite. It is a tetrahydroxyflavone and a monomethoxyflavone. Pedalitin is a natural product found in Teucrium hircanicum, Tanacetum vulgare, and other organisms with data available. A tetrahydroxy-monohydroxy-flavone, with the four hydroxy groups at C-3,-4,-5 and 6, and the methoxy group at C-7. It has been isolated from a number of plant species, including Eremosparton songoricum, Rabdosia japonica and Ruellia tuberosa. 2-(3,4-Dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-1-benzopyran-4-one is found in fats and oils. 2-(3,4-Dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-1-benzopyran-4-one is isolated from Sesamum indicum (sesame Isolated from Sesamum indicum (sesame). 2-(3,4-Dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-1-benzopyran-4-one is found in fats and oils and sesame.
5-O-Methylembelin
5-O-Methylembelin is a constituent of Myrsine africana (cape myrtle). Constituent of Myrsine africana (cape myrtle) 5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].
Furofoline
Furofoline is found in herbs and spices. Furofoline is an alkaloid from the roots of Ruta graveolens (rue Alkaloid from the roots of Ruta graveolens (rue). Furofoline is found in herbs and spices.
Apoatropine
Bispyribac
D010575 - Pesticides > D006540 - Herbicides D016573 - Agrochemicals CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4218; ORIGINAL_PRECURSOR_SCAN_NO 4215 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4230; ORIGINAL_PRECURSOR_SCAN_NO 4228 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4222; ORIGINAL_PRECURSOR_SCAN_NO 4220 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8980; ORIGINAL_PRECURSOR_SCAN_NO 8978 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4228; ORIGINAL_PRECURSOR_SCAN_NO 4226 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9013; ORIGINAL_PRECURSOR_SCAN_NO 9011 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8981; ORIGINAL_PRECURSOR_SCAN_NO 8979 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4239; ORIGINAL_PRECURSOR_SCAN_NO 4235 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4236; ORIGINAL_PRECURSOR_SCAN_NO 4234 INTERNAL_ID 162; CONFIDENCE standard compound; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9005; ORIGINAL_PRECURSOR_SCAN_NO 9003 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9005; ORIGINAL_PRECURSOR_SCAN_NO 9003 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9025; ORIGINAL_PRECURSOR_SCAN_NO 9024 CONFIDENCE standard compound; INTERNAL_ID 162; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9031; ORIGINAL_PRECURSOR_SCAN_NO 9028
Thiolactomycin
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
Etaconazole
6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole
Pivampicillin
Pivampicillin is only found in individuals that have used or taken this drug. It is an analog of ampicillin.Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis. J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic Same as: D08396
R-Soterenol
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
Talactoferrin Alfa
D000970 - Antineoplastic Agents
CoA 10:5;O3
An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 5-hydroxyferulic acid.
dTDP-beta-L-daunosamine
A dTDP-sugar having beta-L-daunosamine as the sugar component.
aspoxicillin
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic Same as: D07469
Myebrol
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D009676 - Noxae > D000477 - Alkylating Agents D000970 - Antineoplastic Agents Same as: D02020
(S)-ATPA
A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a 5-tert-butyl-3-hydroxy-isooxazol-4-yl group.
5,8-Diethoxypsoralen
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers D049990 - Membrane Transport Modulators
Balofloxacin
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic D004791 - Enzyme Inhibitors
S-Hydroxymethylglutathione
S-Hydroxymethylglutathione is a critical component of the binding site for activating fatty acids in glutathione-dependent formaldehyde dehydrogenase activity (OMIM: 103710). Formaldehyde dehydrogenase (FDH; EC 1.2.1.1), a widely occurring enzyme, catalyzes the oxidation of S-hydroxymethylglutathione into S-formylglutathione in the presence of NAD (PMID: 2806555). S-Hydroxymethylglutathione is a critical component of the binding site for activating fatty acids in glutathione-dependent formaldehyde dehydrogenase activity. (OMIM 103710)
DHT benzoate
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Chinomethionat
D016573 - Agrochemicals D010575 - Pesticides
m-Ethyl_toluene
m-Ethyl_toluene belongs to the family of Toluenes. These are compounds containing a benzene ring which bears a methane group.
(±)-2,4,6-Triphenyl-1-hexene
Styrene trimer. Present as an impurity in polystyrene food containers and other products - liberated on heating. Styrene trimer. Present as an impurity in polystyrene food containers and other products - liberated on heating
2,4-Diphenyl-1-butene
2,4-Diphenyl-1-butene is a styrene dimer. Present as an impurity in polystyrene food containers and other products - liberated on heatin
Karphos
CONFIDENCE standard compound; INTERNAL_ID 790; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9696; ORIGINAL_PRECURSOR_SCAN_NO 9695 CONFIDENCE standard compound; INTERNAL_ID 790; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9735; ORIGINAL_PRECURSOR_SCAN_NO 9730 CONFIDENCE standard compound; INTERNAL_ID 790; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9644; ORIGINAL_PRECURSOR_SCAN_NO 9642 CONFIDENCE standard compound; INTERNAL_ID 790; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9682; ORIGINAL_PRECURSOR_SCAN_NO 9680 CONFIDENCE standard compound; INTERNAL_ID 790; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9725; ORIGINAL_PRECURSOR_SCAN_NO 9724 CONFIDENCE standard compound; INTERNAL_ID 790; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9709; ORIGINAL_PRECURSOR_SCAN_NO 9708
Tetrahydrodeoxycortisol
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid, the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approx. 5\\% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4\\%) and the T-allele of the −344 C/T polymorphism of CYP11B2 is more strongly assocd. with higher THS levels than the C-allele. (PMID: 16984984, 15522937, 15272911) [HMDB] Tetrahydrodeoxycortisol (THS) is a mineralocorticoid, the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5\\% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4\\%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. (PMID: 16984984, 15522937, 15272911). D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Androstane-3,17-diol dipropionate
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Troxilin B3
Troxilin B3 is the enzymatically formed derivative of Hepoxilin B3. Normal human epidermis incubated with exogenous AA produces 12-oxo-eicosatetraenoic acid (12-oxo-ETE), hepoxilin A3 (HxA3), and hepoxilin B3 (HxB3) through the 12- Lipoxygenase (LO) pathway. 12-LO is the major arachidonic acid (AA) oxygenation pathway in epidermal cells with total product formation generally exceeding cyclooxygenase activity. Platelet-type 12-LO has been found to be the predominant isoenzyme expressed in human and murine skin epidermis. Increased levels of nonesterified hepoxilins and trioxilins occur in the psoriatic scales. Normal human epidermis synthesized only one of the two possible 10-hydroxy epimers of HxB3 whose formation is probably catalyzed by 12-LO. Hepoxilins exert action on plasma permeability on skin, and induce a specific-receptor-dependent Ca2+ mobilization from endogenous sources and the release of AA and diacylglycerols. (PMID: 11851887) [HMDB] Troxilin B3 is the enzymatically formed derivative of Hepoxilin B3. Normal human epidermis incubated with exogenous AA produces 12-oxo-eicosatetraenoic acid (12-oxo-ETE), hepoxilin A3 (HxA3), and hepoxilin B3 (HxB3) through the 12- Lipoxygenase (LO) pathway. 12-LO is the major arachidonic acid (AA) oxygenation pathway in epidermal cells with total product formation generally exceeding cyclooxygenase activity. Platelet-type 12-LO has been found to be the predominant isoenzyme expressed in human and murine skin epidermis. Increased levels of nonesterified hepoxilins and trioxilins occur in the psoriatic scales. Normal human epidermis synthesized only one of the two possible 10-hydroxy epimers of HxB3 whose formation is probably catalyzed by 12-LO. Hepoxilins exert action on plasma permeability on skin, and induce a specific-receptor-dependent Ca2+ mobilization from endogenous sources and the release of AA and diacylglycerols. (PMID: 11851887).
11H-14,15-EETA
11H-14,15-EETA is an epoxyeicosatrienoic acid. Epoxyeicosatrienoic acids (EpETrEs) have been reported recently having vasodilatory effects and a role of P-450-dependent arachidonic acid monooxygenase metabolites is suggested in vasoregulation. The physiological role of this compound has not been totally established, although in other tissues EpETrEs are mainly involved in hormone production and in the vascular and renal systems. Some studies have implicated epoxygenase metabolites of arachidonic acid in the control of steroidogenesis in luteinised granulosa cells. (PMID: 12749593, 12361727, 1650001) [HMDB] 11H-14,15-EETA is an epoxyeicosatrienoic acid. Epoxyeicosatrienoic acids (EpETrEs) have been reported recently having vasodilatory effects and a role of P-450-dependent arachidonic acid monooxygenase metabolites is suggested in vasoregulation. The physiological role of this compound has not been totally established, although in other tissues EpETrEs are mainly involved in hormone production and in the vascular and renal systems. Some studies have implicated epoxygenase metabolites of arachidonic acid in the control of steroidogenesis in luteinised granulosa cells. (PMID: 12749593, 12361727, 1650001).
8(R)-Hydroperoxylinoleic acid
8(R)-hydroperoxylinoleic acid (8(R)-EPODE) is an oxidized product of linoleic acid. Oxidized lipids such as 8(R)-HPODE can decrease cellular proteoglycan metabolism in endothelial monolayers and alter mRNA levels of major specific proteoglycans in a concentration-dependent manner. This may have implications in lipid-mediated disruption of endothelial barrier function and atherosclerosis. (PMID: 8645361, 9507987).
1-deoxy-L-glycero-tetrulose 4-phosphate
1-deoxy-l-glycero-tetrulose 4-phosphate, also known as 3,4-dihydroxy-2-butanone 4-phosphate or 2-hydroxy-3-oxobutyl phosphate, is a member of the class of compounds known as monoalkyl phosphates. Monoalkyl phosphates are organic compounds containing a phosphate group that is linked to exactly one alkyl chain. 1-deoxy-l-glycero-tetrulose 4-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). 1-deoxy-l-glycero-tetrulose 4-phosphate can be found in a number of food items such as chinese chives, carob, fruits, and cherimoya, which makes 1-deoxy-l-glycero-tetrulose 4-phosphate a potential biomarker for the consumption of these food products. 1-deoxy-l-glycero-tetrulose 4-phosphate exists in E.coli (prokaryote) and yeast (eukaryote).
7-Glutarylaminocephalosporanate
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
Episterol
Episterol belongs to the class of organic compounds known as ergosterols and derivatives. These are steroids containing ergosta-5,7,22-trien-3beta-ol or a derivative thereof, which is based on the 3beta-hydroxylated ergostane skeleton. Thus, episterol is considered to be a sterol lipid molecule. Episterol is involved in the biosynthesis of steroids. Episterol is converted from 24-methylenelophenol. Episterol is converted into 5-dehydroepisterol by lathosterol oxidase (EC 1.14.21.6). Episterol is involved in the biosynthesis of steroids. Episterol is converted from 24-Methylenelophenol. Episterol is converted to 5-Dehydroepisterol by lathosterol oxidase [EC:1.14.21.6]. [HMDB]. Episterol is found in many foods, some of which are common chokecherry, eggplant, wax gourd, and red huckleberry.
ST 28:0;O3
Typhasterol in which the oxygen atom of the keto group has been substituted by two hydrogen atoms. A member of a biosynthetic pathway to castasterone, it has been isolated from the primary roots of maize.
all-trans-3,4-didehydrolycopene
All-trans-3,4-didehydrolycopene is a member of the class of compounds known as carotenes. Carotenes are a type of unsaturated hydrocarbons containing eight consecutive isoprene units. They are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Thus, all-trans-3,4-didehydrolycopene is considered to be an isoprenoid lipid molecule. All-trans-3,4-didehydrolycopene can be found in a number of food items such as kale, giant butterbur, citrus, and ginkgo nuts, which makes all-trans-3,4-didehydrolycopene a potential biomarker for the consumption of these food products.
6-(alpha-D-Glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate
A myo-inositol cyclic phosphate that is 1D-myo-inositol 1,2-cyclic phosphate having an alpha-D-glucosaminyl residue attached at the 6-position.
3-Oxooctadecanoyl-CoA
3-Oxooctadecanoyl-CoA is a metabolite intermediate in the microsomal fatty acid chain elongation system. Microsomal electron-transport components NADPH-cytochrome P450 reductase (EC 1.6.2.4) and cytochrome b5 (EC 1.6.2.2) participate in the conversion from 3-Oxooctadecanoyl-CoA to beta-hydroxystearoyl-CoA, the first reductive step of the microsomal chain elongating system initiated by NADPH. (PMID: 6404652) [HMDB] 3-Oxooctadecanoyl-CoA is a metabolite intermediate in the microsomal fatty acid chain elongation system. Microsomal electron-transport components NADPH-cytochrome P450 reductase (EC 1.6.2.4) and cytochrome b5 (EC 1.6.2.2) participate in the conversion from 3-Oxooctadecanoyl-CoA to beta-hydroxystearoyl-CoA, the first reductive step of the microsomal chain elongating system initiated by NADPH. (PMID: 6404652).
2,6-Dibromophenol
2,6-Dibromophenol is found in crustaceans. 2,6-Dibromophenol is an important flavour component of marine fish, molluses and crustacean 2,6-Dibromophenol is an endogenous metabolite.
13Z-docosenoyl-CoA
13Z-docosenoyl-CoA is also known as C22:1(N-9) -CoA or Erucyl-CoA. 13Z-docosenoyl-CoA is considered to be practically insoluble (in water) and acidic. 13Z-docosenoyl-CoA is a fatty ester lipid molecule
N-Didesmethyl-tamoxifen
N-Didesmethyl-tamoxifen is a metabolite of tamoxifen. Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. (Wikipedia)
Alcophosphamide
Detoxification of cyclophosphamide is effected, in part, by hepatic class 1 aldehyde dehydrogenase (ALDH-1)-catalyzed oxidation of aldophosphamide, a pivotal aldehyde intermediate, to the nontoxic metabolite, carboxyphosphamide. Detoxification of aldophosphamide may also be effected by enzymes, viz. Thus, NAD-linked oxidation and NADPH-linked reduction of aldophosphamide catalyzed by relevant erythrocyte enzymes were quantified. (PMID: 9394035) It has already been demonstrated that horse liver alcohol dehydrogenase catalyzes the reduction of aldophosphamide to alcophosphamide. (PMID: 8216347) D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards
6-Mercaptopurine ribonucleoside triphosphate
6-Mercaptopurine ribonucleoside triphosphate is a metabolite of mercaptopurine. Mercaptopurine (also called 6-mercaptopurine, 6-MP or its brand name Purinethol) is an immunosuppressive drug. It is a thiopurine. (Wikipedia)
Neosurugatoxin
D009676 - Noxae > D011042 - Poisons > D008978 - Mollusk Venoms D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins D009676 - Noxae > D011042 - Poisons > D014688 - Venoms
Hydnocarpic acid
An optically active form of hydnocarpic acid having (R)-configuration. A cyclopentenyl fatty acid consisting of undecanoic acid having a cyclopent-2-enyl group at the 11-position.
Eucarvone
Eucarvone is a member of the class of compounds known as monocyclic monoterpenoids. Monocyclic monoterpenoids are monoterpenoids containing 1 ring in the isoprene chain. Eucarvone is slightly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Eucarvone can be found in blackcurrant, which makes eucarvone a potential biomarker for the consumption of this food product.
dihomomethionine
A sulfur-containing amino acid consisting of 2-aminohexanoic acid having a methylthio substituent at the 6-position.
beta-Terpineol
beta-Terpineol is found in cardamom. beta-Terpineol is a flavouring ingredient.Terpineol is a naturally occurring monoterpene alcohol that has been isolated from a variety of sources such as cajuput oil, pine oil, and petitgrain oil. There are three isomers, alpha-, beta-, and gamma-terpineol, the last two differing only by the location of the double bond. Terpineol is usually a mixture of these isomers with alpha-terpineol as the major constituent. (Wikipedia). Terpineol is a naturally occurring monoterpene alcohol that has been isolated from a variety of sources such as cajuput oil, pine oil, and petitgrain oil. There are three isomers, alpha-, beta-, and gamma-terpineol, the last two differing only by the location of the double bond. Terpineol is usually a mixture of these isomers with alpha-terpineol as the major constituent. cis-beta-Terpineol is found in caraway, rosemary, and common sage.
gamma-Terpineol
gamma-Terpineol is found in ceylan cinnamon. gamma-Terpineol is isolated from carrot oils, from the cinnamon tree (Cinnamomum zeylanicum) and Scotch pine (Pinus sylvestris).Terpineol is a naturally occurring monoterpene alcohol that has been isolated from a variety of sources such as cajuput oil, pine oil, and petitgrain oil. There are three isomers, alpha-, beta-, and gamma-terpineol, the last two differing only by the location of the double bond. Terpineol is usually a mixture of these isomers with alpha-terpineol as the major constituent. (Wikipedia). Isolated from carrot oils, from the cinnamon tree (Cinnamomum zeylanicum) and Scotch pine (Pinus sylvestris)
Cerebronic acid
Constituent of various glycosphingolipids of wheat, corn and other plant subspecies Cerebronic acid is found in peanut and cereals and cereal products. D-Cerebronic acid is found in mushrooms. D-Cerebronic acid is isolated from Polyporus umbellatus (zhu ling).
Albaflavenone
A carbotricyclic compound that is (+)-epi-isozizaene in which the hydrogens at position 5 have been replaced by an oxo group.
(E)-1-O-Cinnamoyl-beta-D-glucose
(E)-1-O-Cinnamoyl-beta-D-glucose is found in fruits. (E)-1-O-Cinnamoyl-beta-D-glucose is a constituent of Vaccinium vitis-idaea (cowberry)
CMP-N-glycoloyl-beta-neuraminate(2-)
CMP-N-glycoloyl-beta-neuraminate(2-) is also known as CMP-N-Glycoloyl-beta-neuraminic acid. CMP-N-glycoloyl-beta-neuraminate(2-) is considered to be soluble (in water) and acidic
Ureidoisobutyric acid
Ureidoisobutyric acid, also known as 3-ureidoisobutyrate or beta-UBA, belongs to the class of organic compounds known as ureas. Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group. Ureidoisobutyric acid is an extremely weak basic (essentially neutral) compound (based on its pKa). Ureidoisobutyric acid exists in all living organisms, ranging from bacteria to humans. Within humans, ureidoisobutyric acid participates in a number of enzymatic reactions. In particular, ureidoisobutyric acid can be biosynthesized from dihydrothymine through its interaction with the enzyme dihydropyrimidinase. Outside of the human body, ureidoisobutyric acid has been detected, but not quantified in, several different foods, such as bread, squashberries, black elderberries, black crowberries, and climbing beans. This could make ureidoisobutyric acid a potential biomarker for the consumption of these foods. Ureidoisobutyric acid is increased in the urine of patients with beta-ureidopropionase (EC 3.5.1.6) deficiency (PMID: 12271438), a genetic disorder. Ureidoisobutyric acid can be used to predict a patients individual phenotypes of enzyme deficiencies in pyrimidine metabolism when associated with a risk for severe toxicity against the antineoplastic agent 5-fluorouracil (PMID: 12798197).
N-Acetylneuraminic acid 9-phosphate
N-Acetylneuraminic acid 9-phosphate is an intermediate in the synthesis of Acetylneuraminic acid, a process occurring in the cytosolic fraction by the human enzyme N-Acetylneuraminic acid 9-phosphate (Neu5Ac 9-P) synthase, that catalyzes the synthesis of N-Acetylneuraminic acid 9-phosphate, in a reaction by the mechanism of aldol condensation of phosphoenolpyruvate (PEP) with sugar substrates, ManNAc-6-P (N-acetylmannosamine 6-phosphate) or Man-6-P (mannose 6-phosphate). N-Acetylneuraminic acid 9-phosphate is converted to N-Acetylneuraminic acid by the enzyme N-acetylneuraminate-9-phosphate phosphatase. (PMID: 16503877, 6093772) [HMDB] N-Acetylneuraminic acid 9-phosphate is an intermediate in the synthesis of Acetylneuraminic acid, a process occurring in the cytosolic fraction by the human enzyme N-Acetylneuraminic acid 9-phosphate (Neu5Ac 9-P) synthase, that catalyzes the synthesis of N-Acetylneuraminic acid 9-phosphate, in a reaction by the mechanism of aldol condensation of phosphoenolpyruvate (PEP) with sugar substrates, ManNAc-6-P (N-acetylmannosamine 6-phosphate) or Man-6-P (mannose 6-phosphate). N-Acetylneuraminic acid 9-phosphate is converted to N-Acetylneuraminic acid by the enzyme N-acetylneuraminate-9-phosphate phosphatase. (PMID: 16503877, 6093772).
Phosphodimethylethanolamine
Phosphomonomethylethanolamine, phosphodimethylethanolamine and phosphocholine were weak competitive inhibitors of the cytidylyltransferase catalyzed reaction when phosphoethanolamine was used as a substrate, with Ki values of 7.0, 6.8 and 52.9 mM, respectively. (PMID: 8130268) Unlike the plant and Plasmodium PEAMT, which catalyze all three methylations in the pathway, PMT-2 catalyzes only the last two steps in the pathway, i.e., the methylation of phosphomonomethylethanolamine (P-MME) to phosphodimethylethanolamine (P-DME) and of P-DME to phosphocholine. (PMID: 16681378)
4-Hydroxybenoyl-CoA
This compound belongs to the family of Acyl CoAs. These are organic compounds contaning a coenzyme A substructure linked to another moeity through an ester bond.
(10E,12Z)-(9S)-9-Hydroperoxyoctadeca-10,12-dienoic acid
(9s,10e,12z,15z)-9-hydroperoxy-10,12,15-octadecadienoate, also known as 9(S)-hpod or 9-hydroperoxy-11,12-octadecadienoic acid, belongs to lineolic acids and derivatives class of compounds. Those are derivatives of lineolic acid. Lineolic acid is a polyunsaturated omega-6 18 carbon long fatty acid, with two CC double bonds at the 9- and 12-positions. Thus, (9s,10e,12z,15z)-9-hydroperoxy-10,12,15-octadecadienoate is considered to be an octadecanoid lipid molecule (9s,10e,12z,15z)-9-hydroperoxy-10,12,15-octadecadienoate is practically insoluble (in water) and a weakly acidic compound (based on its pKa). (9s,10e,12z,15z)-9-hydroperoxy-10,12,15-octadecadienoate can be found in a number of food items such as burdock, oat, parsnip, and cocoa bean, which makes (9s,10e,12z,15z)-9-hydroperoxy-10,12,15-octadecadienoate a potential biomarker for the consumption of these food products. (10E,12Z)-(9S)-9-Hydroperoxyoctadeca-10,12-dienoic acid, also known as 9(S)-HPOD or (9S,10E,12Z)-9-Hydroperoxy-10,12-octadecadienoate, is classified as a lineolic acid or a Lineolic acid derivative. Lineolic acids are derivatives of lineolic acid. Lineolic acid is a polyunsaturated omega-6 18 carbon long fatty acid, with two CC double bonds at the 9- and 12-positions. (10E,12Z)-(9S)-9-Hydroperoxyoctadeca-10,12-dienoic acid is considered to be practically insoluble (in water) and acidic. (10E,12Z)-(9S)-9-Hydroperoxyoctadeca-10,12-dienoic acid is an octadecanoid lipid molecule. (10E,12Z)-(9S)-9-Hydroperoxyoctadeca-10,12-dienoic acid can be found throughout numerous foods such as Barley, Prunus (Cherry, Plum), Cherimoya, and Prairie turnips D004791 - Enzyme Inhibitors > D016859 - Lipoxygenase Inhibitors D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
Racemethorphan
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids D019141 - Respiratory System Agents > D000996 - Antitussive Agents D002491 - Central Nervous System Agents
2-[6-Fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]-1-indenyl]acetic acid
Baciguent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
Balofloxacin
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic D004791 - Enzyme Inhibitors
Fenspiride
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents R - Respiratory system > R03 - Drugs for obstructive airway diseases
Verlukast
N-acetyl Leukotriene E4
S-DNP-Glutathione
Soterenol monohydrochloride
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
(S)-3-hydroxydecanoyl-CoA
(s)-3-hydroxydecanoyl-coa, also known as 3-oh 10:0-coa or beta-hydroxydecanoyl coenzyme a, is a member of the class of compounds known as (s)-3-hydroxyacyl coas (s)-3-hydroxyacyl coas are organic compounds containing a (S)-3-hydroxyl acylated coenzyme A derivative (s)-3-hydroxydecanoyl-coa is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). (s)-3-hydroxydecanoyl-coa can be found in a number of food items such as black crowberry, pomegranate, deerberry, and winter savory, which makes (s)-3-hydroxydecanoyl-coa a potential biomarker for the consumption of these food products (s)-3-hydroxydecanoyl-coa may be a unique S.cerevisiae (yeast) metabolite.
3,5-Dibromo-4-hydroxybenzoic acid
A monohydroxybenzoic acid that is p-salicylic acid with bromo- substituents at C-3 and C-5 of the benzene ring.
Demethylmedicarpin
(6ar,11ar)-3,9-dihydroxypterocarpan is a member of the class of compounds known as pterocarpans. Pterocarpans are benzo-pyrano-furano-benzene compounds, containing the 6H-[1]benzofuro[3,2-c]chromene skeleton. They are derivatives of isoflavonoids. Thus, (6ar,11ar)-3,9-dihydroxypterocarpan is considered to be a flavonoid lipid molecule (6ar,11ar)-3,9-dihydroxypterocarpan is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). (6ar,11ar)-3,9-dihydroxypterocarpan can be found in a number of food items such as bayberry, sweet bay, agave, and red bell pepper, which makes (6ar,11ar)-3,9-dihydroxypterocarpan a potential biomarker for the consumption of these food products.
fenspiride
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents R - Respiratory system > R03 - Drugs for obstructive airway diseases
Isogentisin
A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1 and 3 and a methoxy group at position 7.
5-O-Methylembelin
5-O-methyl embelin is a member of the class of monohydroxy-1,4-benzoquinones that is embelin in which the hydroxy group at position 5 is replaced by a methoxy group. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antileishmanial activity as well as inhibitory activity towards hepatitis C protease. It has a role as a metabolite, a hepatitis C protease inhibitor, an antileishmanial agent and an antineoplastic agent. It is an enol ether and a member of monohydroxy-1,4-benzoquinones. It is functionally related to an embelin. 5-O-Methylembelin is a natural product found in Lysimachia punctata, Embelia schimperi, and other organisms with data available. 5-O-Methylembelin is a constituent of Myrsine africana (cape myrtle). Constituent of Myrsine africana (cape myrtle) 5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].
Benzoylecgonine
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2823
thiethylperazine
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AD - Phenothiazine derivatives D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent D005765 - Gastrointestinal Agents > D000932 - Antiemetics D002491 - Central Nervous System Agents Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
Sumaresinolic acid
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.531 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.529 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.540 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.537
3-CMP
A cytidine 3-phosphate compound with a monophosphate group at the 3-position. relative retention time with respect to 9-anthracene Carboxylic Acid is 0.054 Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group[1]. Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group[1].
N-Methylanthranilic acid
An aromatic amino acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is substituted by a methyl group. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].
pivampicillin
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic Same as: D08396
RESORCINOL MONOACETATE
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent Same as: D02393
3-Mercaptolactic acid
A (2R)-2-hydroxy monocarboxylic acid consisting of lactic acid having a sulfanyl group at the 3-position.
FA 5:1;O2
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides D018377 - Neurotransmitter Agents > D004399 - Dynorphins 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.
20-Hydroxy-leukotriene E4
CoA 20:3
CoA 5:1;O
CoA 18:1;O
A 3-oxo-fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3-oxooctadecanoic acid.
CoA 22:1
Elephantopin
7β-Eplerenone Impurity
Glutaryl-7-aminocephalosporanic acid
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
Protirelina
H - Systemic hormonal preparations, excl. sex hormones and insulins > H01 - Pituitary and hypothalamic hormones and analogues > H01A - Anterior pituitary lobe hormones and analogues > H01AB - Thyrotropin
mitobronitol
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D009676 - Noxae > D000477 - Alkylating Agents D000970 - Antineoplastic Agents
BETA-TERPINEOL
A member of the class of terpineols that is cyclohexanol carrying additional methyl and propenyl substituents at positions 1 and 4 respectively.
AI3-05924
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].
CMP-N-glycoloyl-beta-neuraminate(2-)
CMP-N-glycoloyl-beta-neuraminate(2-) is also known as CMP-N-Glycoloyl-beta-neuraminic acid. CMP-N-glycoloyl-beta-neuraminate(2-) is considered to be soluble (in water) and acidic
Stanolone benzoate
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
n-[(2r)-1-Phenylpropan-2-yl]prop-2-yn-1-amine
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
ethotoin
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AB - Hydantoin derivatives C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants D049990 - Membrane Transport Modulators
MALEIC HYDRAZIDE
D006133 - Growth Substances > D010937 - Plant Growth Regulators D010575 - Pesticides > D006540 - Herbicides D016573 - Agrochemicals
carbinoxamine
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Phenindamine
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
4-Chlorophenylacetic acid
A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-chlorophenyl group.
11-Aminoundecanoic acid
11-Aminoundecanoic acid is an organic compound with the formula H2N(CH2)10CO2H. This white solid is classified as an amine and a fatty acid. 11-Aminoundecanoic acid is a precursor to Nylon-11.[1] As practiced by Arkema, 11-aminoundecanoic acid is prepared industrially from undecylenic acid, which is derived from castor oil.[2] The synthesis proceeds in four separate reactions: 1. Transesterification of castor oil to methyl ricinoleate: Crude castor oil consists of about 80\% triglycerides, from the ricinoleic acid, itself representing about 90\% of the oil.[3] It is quantitatively transesterified with methanol to methyl ricinoleate (the methyl ester of ricinoleic acid) in the presence of the basic sodium methoxide at 80 °C within 1 h reaction time in a stirred reactor. At the end of the reaction, the resulting glycerol separates and the liquid methyl ester is washed with water to remove residual glycerol. 2. Pyrolysis of methylricinoleate to heptanal and methyl undecenoate: Methylricinoleate is evaporated at 250 °C, mixed with hot steam (600 °C) in a 1:1 ratio and decomposed in a cracking furnace at 400 - 575 °C at a retention time of about 10 seconds into its cleavage products heptanal and methyl undecenoate. The cleavage of the aliphatic chain occurs in this variant of the steam cracking selectively between the hydroxymethylene and the allyl-methylene group. Besides heptanal and methyl undecenoate, a mixture of methyl esters of saturated and unsaturated C18-carboxylic acids is obtained. This mixture is known under the trade name Esterol and is used as a lubricant additive. 3. Hydrolysis of methyl undecenoate to 10-undecenoic acid The hydrolysis of the methyl ester with sodium hydroxide proceeds at 25 °C within 30 min with quantitative yield. After acidification with hydrochloric acid, solid 10-undecenoic acid (undecylenic acid) is obtained. 4. Hydrobromination of 10-undecenoic acid to 11-bromoundecanoic acid The undecenoic acid is dissolved in toluene and, in the presence of the radical initiator benzoyl peroxide (BPO), gaseous hydrogen bromide is added, in contrary to the Markovnikov rule ("anti-Markovnikov"). When cooled to 0 °C, the fast and highly exothermic reaction produces 11-bromoundecanoic acid in 95\% yield - the Markovnikov product 10-bromoundecanoic acid is produced in small quantities as a by-product. Toluene and unreacted hydrogen bromide are extracted under reduced pressure and reused. 5. Bromine exchange of 11-bromoundecanoic acid to 11-aminoundecanoic acid 11-Bromodecanoic acid is mixed at 30 °C with a large excess of 40\% aqueous ammonia solution. When the reaction is complete, water is added and the mixture is heated to 100 °C to remove the excess ammonia. The acid can be recrystallized from water. For further purification, the hydrochloride of 11-aminoundecanoic acid, which is available by acidification with hydrochloric acid, can be recrystallized from a methanol/ethyl acetate mixture. Aminoundecanoic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=2432-99-7 (retrieved 2024-07-01) (CAS RN: 2432-99-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
LYSERGAMIDE
An ergoline alkaloid comprising ergoline lacking hydrogens at positions 9 and 10 and also having a methyl group attached to the piperidine nitrogen.