Balofloxacin (BioDeep_00000009655)

   

natural product


代谢物信息卡片


Balofloxacin, (R)-

化学式: C20H24FN3O4 (389.1751)
中文名称: 巴洛沙星
谱图信息: 最多检出来源 Homo sapiens(plant) 11.04%

分子结构信息

SMILES: CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI: InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)

描述信息

D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors

同义名列表

3 个代谢物同义名

Balofloxacin, (R)-; Balofloxacin; Balofloxacin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Qi Wen, Xian-Jie Liu, Wei-Cong Zhu, Lu Li, Min-Yi Li, Xuna-Xian Peng, Hui Li. Characterization of balofloxacin-stressed proteomics and identification of balofloxacin-binding proteins pre-peptidase and integration host factor in Edwardsiella tarda. Journal of proteomics. 2019 08; 205(?):103413. doi: 10.1016/j.jprot.2019.103413. [PMID: 31181269]
  • Xiuyun Ren, Hongyun Qian, Peixiao Tang, Yuling Tang, Yuanyuan Liu, Hongyu Pu, Man Zhang, Ludan Zhao, Hui Li. Preparation, Characterization, and Properties of Inclusion Complexes of Balofloxacin with Cyclodextrins. AAPS PharmSciTech. 2019 Aug; 20(7):278. doi: 10.1208/s12249-019-1425-9. [PMID: 31396732]
  • G Shankar, Roshan M Borkar, Suresh Udutha, Suresh Pal Anagoni, R Srinivas. Identification and structural characterization of in vivo metabolites of balofloxacin in rat plasma, urine and feces samples using Q-TOF/LC/ESI/MS/MS : In silico toxicity studies. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 159(?):200-211. doi: 10.1016/j.jpba.2018.06.050. [PMID: 29990887]
  • Jin Deng, Zhenghua Xiao, Huijing Zhang, Mengjun Zhang, Jianlin Tang. [Determination of balofloxacin in human plasma by HPLC with solid-phase extraction]. Se pu = Chinese journal of chromatography. 2007 Nov; 25(6):942-3. doi: NULL. [PMID: 18257322]
  • Zuwei Bian, Yuan Tian, Zunjian Zhang, Fengguo Xu, Jinheng Li, Xiaomei Cao. High performance liquid chromatography-electrospray ionization mass spectrometric determination of balofloxacin in human plasma and its pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 May; 850(1-2):68-73. doi: 10.1016/j.jchromb.2006.11.001. [PMID: 17161665]
  • Zheng-Yu Yan, Xiu-Fen Shao, Xin-Min Jiang, Yu-Zhu Hu. [Studies on the reaction of balofloxacin with bovine serum albumin]. Guang pu xue yu guang pu fen xi = Guang pu. 2006 Aug; 26(8):1494-8. doi: NULL. [PMID: 17058955]
  • Dong Seop Kim, Ki-Suk Kim, Ki Hwan Choi, Hankwang Na, Joo-Il Kim, Won-Ho Shin, Eun-Joo Kim. Electrophysiological safety of novel fluoroquinolone antibiotic agents gemifloxacin and balofloxacin. Drug and chemical toxicology. 2006; 29(3):303-12. doi: 10.1080/01480540600652996. [PMID: 16777708]
  • K Marutani, Y Otabe, M Nagamuta, S Matsubara, H Otani. Photoallergenicity of a fluoroquinolone antibacterial agent with a fluorine substituent at the 8-position in guinea pigs exposed to long-wavelength UV light. Skin pharmacology and applied skin physiology. 1998; 11(4-5):232-40. doi: 10.1159/000029832. [PMID: 9885407]
  • O Kozawa, T Uematsu, H Matsuno, M Niwa, S Nagashima, M Kanamaru. Comparative study of pharmacokinetics of two new fluoroquinolones, balofloxacin and grepafloxacin, in elderly subjects. Antimicrobial agents and chemotherapy. 1996 Dec; 40(12):2824-8. doi: 10.1128/aac.40.12.2824. [PMID: 9124849]
  • M Kurata, Y Kasuga, E Nanba, H Nakamura, T Asano, K Haruta. Flush induced by fluoroquinolones in canine skin. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 1995 Nov; 44(11):461-5. doi: 10.1007/bf01837910. [PMID: 8597878]
  • M Obana, S Irimajiri, I Tomizawa, Y Takizawa, Y Sakamoto, Y Nitta, T Tsunoda, H Fukuda, T Yamaguchi, G Masuda. [clinical study of balofloxacin on infectious enteritis and assessment of the fecal drug concentration and intestinal microbial flora in patients with inpatients with infectious enteritis. Research group of balofloxacin on infectious enteritis]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 1995 Sep; 69(9):991-1006. doi: 10.11150/kansenshogakuzasshi1970.69.991. [PMID: 7594801]
  • M Ooishi, M Miyao, T Abe, T Sasagawa, M Motoyama, T Nakagawa, T Okutomi. [Pharmacokinetics of balofloxacin in the intraocular tissues of pigmented rabbits]. The Japanese journal of antibiotics. 1995 Sep; 48(9):1274-80. doi: NULL. [PMID: 7474337]
  • T Nakagawa, M Ishigai, Y Hiramatsu, H Kinoshita, Y Ishitani, K Ohkubo, A Okazaki. Determination of the new fluoroquinolone balofloxacin and its metabolites in biological fluids by high performance liquid chromatography. Arzneimittel-Forschung. 1995 Jun; 45(6):716-8. doi: . [PMID: 7646578]
  • T Nakagawa, M Ishigai, M Kato, N Hayakawa, H Kinoshita, T Okutomi, K Ohkubo, A Okazaki. Pharmacokinetics of the new fluoroquinolone balofloxacin in mice, rats, and dogs. Arzneimittel-Forschung. 1995 Jun; 45(6):719-22. doi: . [PMID: 7646579]
  • H Iwasaki, S Miyazaki, A Tsuji, K Yamaguchi, S Goto. In vitro and in vivo antibacterial activities of Q-35, a novel fluoroquinolone. Chemotherapy. 1995 Mar; 41(2):100-12. doi: 10.1159/000239330. [PMID: 7758353]
  • K Suzuki, M Horiba, K Ishikawa, S Katoh, Y Naide, M Yanaoka, S Andoh. Laboratory and clinical study of balofloxacin (Q-35), a new fluoroquinolone, in urinary tract infection. Drugs. 1995; 49 Suppl 2(?):376-8. doi: 10.2165/00003495-199500492-00103. [PMID: 8549367]