4-Amino-3-hydroxybutyrate (BioDeep_00000005277)

 

Secondary id: BioDeep_00001868743

human metabolite


代谢物信息卡片


4-Amino-3-hydroxybutyric acid, (Z)-2-butenedioate salt (2:1), (+-)-isomer

化学式: C4H9NO3 (119.0582)
中文名称: 4-氨基-3-羟基丁酸, 3-羟基-4-氨基丁酸
谱图信息: 最多检出来源 Homo sapiens(otcml) 12.76%

分子结构信息

SMILES: C(C(CN)O)C(=O)O
InChI: InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 1 BDNF
Peripheral membrane protein 1 AOC1
Endoplasmic reticulum membrane 2 GABBR1, HSP90B1
Nucleus 1 HSP90B1
cytosol 1 HSP90B1
dendrite 1 BDNF
mitochondrial membrane 1 GABBR1
Cell membrane 6 AGTR2, AOC1, GABBR1, KCNQ2, KCNQ3, KCNQ5
Multi-pass membrane protein 6 AGTR2, GABBR1, KCNQ2, KCNQ3, KCNQ5, MPC1L
Synapse 2 KCNQ2, KCNQ3
cell surface 1 KCNQ3
dendritic shaft 1 GABBR1
glutamatergic synapse 1 GABBR1
mitochondrial inner membrane 1 MPC1L
neuronal cell body 1 GABBR1
presynaptic membrane 1 GABBR1
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 2 BDNF, GABBR1
plasma membrane 7 AGTR2, AOC1, GABBR1, KCNQ2, KCNQ3, KCNQ5, REN
Membrane 7 BDNF, GABBR1, HSP90B1, KCNQ2, KCNQ3, KCNQ5, REN
axon 2 BDNF, CCK
extracellular exosome 2 AOC1, HSP90B1
endoplasmic reticulum 1 HSP90B1
extracellular space 5 AOC1, BDNF, CCK, GABBR1, REN
perinuclear region of cytoplasm 2 BDNF, HSP90B1
Schaffer collateral - CA1 synapse 1 GABBR1
bicellular tight junction 1 AOC1
mitochondrion 2 ABAT, KCNQ3
protein-containing complex 1 HSP90B1
Secreted 3 BDNF, CCK, REN
extracellular region 5 AOC1, BDNF, CCK, HSP90B1, REN
mitochondrial matrix 1 ABAT
Extracellular side 1 AOC1
dendritic spine 1 GABBR1
midbody 1 HSP90B1
apical part of cell 1 REN
postsynaptic membrane 1 GABBR1
Mitochondrion inner membrane 1 MPC1L
focal adhesion 1 HSP90B1
axolemma 1 GABBR1
G protein-coupled GABA receptor complex 1 GABBR1
GABA-ergic synapse 1 GABBR1
Peroxisome 1 AOC1
collagen-containing extracellular matrix 1 HSP90B1
Postsynaptic cell membrane 1 GABBR1
Secreted, extracellular space 1 AOC1
axon initial segment 2 KCNQ2, KCNQ3
Cell projection, dendrite 1 GABBR1
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
voltage-gated potassium channel complex 3 KCNQ2, KCNQ3, KCNQ5
endoplasmic reticulum lumen 2 BDNF, HSP90B1
specific granule lumen 1 AOC1
node of Ranvier 2 KCNQ2, KCNQ3
Sarcoplasmic reticulum lumen 1 HSP90B1
G protein-coupled receptor heterodimeric complex 1 GABBR1
endocytic vesicle lumen 1 HSP90B1
endoplasmic reticulum chaperone complex 1 HSP90B1
clathrin coat 1 KCNQ5
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
4-aminobutyrate transaminase complex 1 ABAT
[Isoform 1E]: Secreted 1 GABBR1


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Nirja K Chaudhari, Laxmipriya P Nampoothiri. Neurotransmitter alteration in a testosterone propionate-induced polycystic ovarian syndrome rat model. Hormone molecular biology and clinical investigation. 2017 Feb; 29(2):71-77. doi: 10.1515/hmbci-2016-0035. [PMID: 27802175]
  • D Jordan, C Poncet, M Veisseire, R Mornex. Role of GABA in the control of thyrotropin secretion in the rat. Brain research. 1983 May; 268(1):105-10. doi: 10.1016/0006-8993(83)90394-3. [PMID: 6860953]
  • G B Melis, A M Paoletti, V Mais, N M Mastrapasqua, F Strigini, F Fruzzetti, G Guarnieri, M Gambacciani, P Fioretti. Dose-related effects of gamma-amino beta-hydroxy butyric acid (GABOB) infusion on growth hormone secretion in normal women. Journal of endocrinological investigation. 1982 Mar; 5(2):101-6. doi: 10.1007/bf03350499. [PMID: 7096918]
  • G Bonardi, A Mondino, S Silvestri, G Zanolo. Absorption, distribution and excretion of DL-gamma-amino-beta-hydroxybutyric acid-1-14C (GABOB-1-14C) in the rat. Arzneimittel-Forschung. 1981; 31(11):1910-3. doi: NULL. [PMID: 7198473]
  • J Takahara, S Yunoki, W Yakushiji, J Yamauchi, H Hosogi, T Ofuji. Stimulatory effects of gamma-aminohydroxybutyric acid (GABOB) on growth hormone, prolactin and cortisol release in man. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1980 Jan; 12(1):31-4. doi: 10.1055/s-2007-996190. [PMID: 6244218]
  • K Matsushita, L R Gjessing. Analysis of gamma-amino-beta-hydroxy butyric acid (GABOB) by chromatography and electrophoresis. Journal of chromatography. 1979 Mar; 162(3):427-32. doi: 10.1016/s0378-4347(00)81531-5. [PMID: 528609]
  • P Fioretti, G B Melis, A M Paoletti, G Parodo, F Caminiti, G U Corsini, L Martini. Gamma-amino-beta-hydroxy butyric acid stimulates prolactin and growth hormone release in normal women. The Journal of clinical endocrinology and metabolism. 1978 Dec; 47(6):1336-40. doi: 10.1210/jcem-47-6-1336. [PMID: 263354]
  • H Abe, Y Kato, K Chihara, S Ohgo, Y Iwasaki. Growth hormone release by gamma-aminobutyric acid (GABA) and gamma-amino-beta-hydroxybutyric acid (GABOB) in the rat. Endocrinologia japonica. 1977 Apr; 24(2):229-31. doi: 10.1507/endocrj1954.24.229. [PMID: 872825]
  • K SATO. [Effect of GABOB (gamma-amino-beta-hydroxybutyric acid) in epilepsy with special reference to EEG-findings due to intravenous injection]. Naika hokan. Japanese archives of internal medicine. 1963 Jan; 10(?):47-54. doi: NULL. [PMID: 13986712]
  • D DE MAIO. [Modern orientations in the therapy of epilepsy in the light of recent acquisitions regarding cerebral metabolism of gamma-amino-butyric acid (GABA) and gamma-amino-beta-hydroxybutyric acid (GABOB)]. La Clinica terapeutica. 1962 Nov; 23(?):832-51. doi: NULL. [PMID: 14025905]
  • E C GORI. [Observations on the clinical use of GABOB (gamma-amino-beta-hydroxybutyric acid). Administration of the drug by intravenous route. (Preliminary observations)]. Giornale di psichiatria e di neuropatologia. 1962; 90(?):853-60. doi: NULL. [PMID: 13949277]