Cicutoxin (BioDeep_00000006764)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


8,10,12-Heptadecatriene-4,6-diyne-1,14-diol,(8E,10E,12E,14R)-

化学式: C17H22O2 (258.162)
中文名称: 毒芹素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 85%

分子结构信息

SMILES: CCCC(C=CC=CC=CC#CC#CCCCO)O
InChI: InChI=1S/C17H22O2/c1-2-14-17(19)15-12-10-8-6-4-3-5-7-9-11-13-16-18/h4,6,8,10,12,15,17-19H,2,11,13-14,16H2,1H3/b6-4+,10-8+,15-12+/t17-/m1/s1

描述信息

同义名列表

5 个代谢物同义名

8,10,12-Heptadecatriene-4,6-diyne-1,14-diol,(8E,10E,12E,14R)-; Cicutoxin; (8E,10E,12E,14R)-heptadeca-8,10,12-trien-4,6-diyne-1,14-diol; FOH 17:7;O; Cicutoxin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kip E Panter, Dale R Gardner, Bryan L Stegelmeier, Kevin D Welch, Dirk Holstege. Water hemlock poisoning in cattle: Ingestion of immature Cicuta maculata seed as the probable cause. Toxicon : official journal of the International Society on Toxinology. 2011 Jan; 57(1):157-61. doi: 10.1016/j.toxicon.2010.11.009. [PMID: 21094658]
  • Giovanni Appendino, Federica Pollastro, Luisella Verotta, Mauro Ballero, Adriana Romano, Paulina Wyrembek, Katarzyna Szczuraszek, Jerzy W Mozrzymas, Orazio Taglialatela-Scafati. Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus. Journal of natural products. 2009 May; 72(5):962-5. doi: 10.1021/np8007717. [PMID: 19245244]
  • Leo J Schep, Robin J Slaughter, Gordon Becket, D Michael G Beasley. Poisoning due to water hemlock. Clinical toxicology (Philadelphia, Pa.). 2009 Apr; 47(4):270-8. doi: 10.1080/15563650902904332. [PMID: 19514873]
  • K B Heath. A fatal case of apparent water hemlock poisoning. Veterinary and human toxicology. 2001 Feb; 43(1):35-6. doi: ". [PMID: 11205076]
  • K Uwai, K Ohashi, Y Takaya, T Ohta, T Tadano, K Kisara, K Shibusawa, R Sakakibara, Y Oshima. Exploring the structural basis of neurotoxicity in C(17)-polyacetylenes isolated from water hemlock. Journal of medicinal chemistry. 2000 Nov; 43(23):4508-15. doi: 10.1021/jm000185k. [PMID: 11087575]
  • M Fujii. [Plant toxicity-coriamyrtin, anisatin, cicutoxin]. Ryoikibetsu shokogun shirizu. 1999; ?(27 Pt 2):682-4. doi: . [PMID: 10434749]
  • U Strauss, U Wittstock, R Schubert, E Teuscher, S Jung, E Mix. Cicutoxin from Cicuta virosa--a new and potent potassium channel blocker in T lymphocytes. Biochemical and biophysical research communications. 1996 Feb; 219(2):332-6. doi: 10.1006/bbrc.1996.0233. [PMID: 8604987]
  • ". From the Centers for Disease Control and Prevention. Water hemlock poisoning--Maine, 1992. JAMA. 1994 May; 271(19):1475. doi: 10.1001/jama.271.19.1475. [PMID: 8176815]
  • ". Water hemlock poisoning--Maine, 1992. MMWR. Morbidity and mortality weekly report. 1994 Apr; 43(13):229-31. doi: ". [PMID: 8145712]
  • D Rizzi, C Basile, A Di Maggio, A Sebastio, F Introna, R Rizzi, A Scatizzi, S De Marco, J E Smialek. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1991; 6(12):939-43. doi: 10.1093/ndt/6.12.939. [PMID: 1798593]
  • R G Dijkstra, R Falkena. [A case of cicutoxine poisoning in ponies]. Tijdschrift voor diergeneeskunde. 1981 Oct; 106(20):1037-9. doi: . [PMID: 7292475]
  • E Starreveld, E Hope. Cicutoxin poisoning (water hemlock). Neurology. 1975 Aug; 25(8):730-4. doi: 10.1212/wnl.25.8.730. [PMID: 1171406]