2-[6-Fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]-1-indenyl]acetic acid (BioDeep_00000174214)
human metabolite blood metabolite
代谢物信息卡片
2-{5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl}acetic acid
化学式: C20H17FO3S (356.0882384)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC1=C(CC(O)=O)C2=C(C=CC(F)=C2)C1=CC1=CC=C(C=C1)S(C)=O
InChI: InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)
描述信息
同义名列表
6 个代谢物同义名
2-{5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl}acetic acid; 2-[6-Fluoro-2-methyl-3-[(4-methylsulphinylphenyl)methylidene]-1-indenyl]acetic acid; 2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]-1-indenyl]acetic acid; 2-[6-Fluoro-2-methyl-3-[(4-methylsulphinylphenyl)methylidene]-1-indenyl]acetate; 2-[6-Fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]-1-indenyl]acetate; Sulindac
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Suhail Razak, Tayyaba Afsar, Nousheen Bibi, Mahmoud Abulmeaty, Mashooq Ahmad Bhat, Anam Inam, Janeen H Trembley, Ali Almajwal, Maria Shabbir, Nawaf W Alruwaili, Abdulrahman Algarni. Sulindac acetohydrazide derivative attenuates against cisplatin induced organ damage by modulation of antioxidant and inflammatory signaling pathways.
Scientific reports.
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Cancer chemotherapy and pharmacology.
2009 Feb; 63(3):477-89. doi:
10.1007/s00280-008-0761-3. [PMID: 18509645] - Patrick Wortman, Yuko Miyazaki, Nishan S Kalupahana, Suyeon Kim, Melissa Hansen-Petrik, Arnold M Saxton, Kate J Claycombe, Brynn H Voy, Jay Whelan, Naima Moustaid-Moussa. n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes.
Nutrition & metabolism.
2009 Jan; 6(?):5. doi:
10.1186/1743-7075-6-5. [PMID: 19159447] - Suzan Wopereis, Carina M Rubingh, Marjan J van Erk, Elwin R Verheij, Trinette van Vliet, Nicole H P Cnubben, Age K Smilde, Jan van der Greef, Ben van Ommen, Henk F J Hendriks. Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes.
PloS one.
2009; 4(2):e4525. doi:
10.1371/journal.pone.0004525. [PMID: 19242536] - Bing Wang, Gerd Bobe, John J LaPres, Leslie D Bourquin. High sucrose diets promote intestinal epithelial cell proliferation and tumorigenesis in APC(Min) mice by increasing insulin and IGF-I levels.
Nutrition and cancer.
2009; 61(1):81-93. doi:
10.1080/01635580802372609. [PMID: 19116878] - Akimitsu Maeda, Shuichi Tsuruoka, Yoshikatsu Kanai, Hitoshi Endou, Kazuyuki Saito, Etsuko Miyamoto, Akio Fujimura. Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells.
European journal of pharmacology.
2008 Oct; 596(1-3):166-72. doi:
10.1016/j.ejphar.2008.08.023. [PMID: 18789319] - Antonio Angelini, Manuela Iezzi, Concetta Di Febbo, Carmine Di Ilio, Franco Cuccurullo, Ettore Porreca. Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs.
Oncology reports.
2008 Oct; 20(4):731-5. doi:
10.3892/or_00000067. [PMID: 18813811] - Fernando Santos, Lígia Teixeira, Marlene Lúcio, Helena Ferreira, Diana Gaspar, José L F C Lima, Salette Reis. Interactions of sulindac and its metabolites with phospholipid membranes: an explanation for the peroxidation protective effect of the bioactive metabolite.
Free radical research.
2008 Jul; 42(7):639-50. doi:
10.1080/10715760802270326. [PMID: 18654879] - Chang-Yin Lee, Yi-Chao Hsu, Jir-You Wang, Chien-Chih Chen, Jen-Hwey Chiu. Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters.
Liver international : official journal of the International Association for the Study of the Liver.
2008 Jul; 28(6):841-55. doi:
10.1111/j.1478-3231.2008.01698.x. [PMID: 18346132] - B Mertens, B Cahay, R Klinkenberg, B Streel. An automated method for the simultaneous determination of pravastatin, 3-hydroxy isomeric metabolite, pravalactone and fenofibric acid in human plasma by sensitive liquid chromatography combined with diode array and tandem mass spectrometry detection.
Journal of chromatography. A.
2008 May; 1189(1-2):493-502. doi:
10.1016/j.chroma.2008.01.060. [PMID: 18342321] - Martin Gamerdinger, Angela B Clement, Christian Behl. Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.
Neuropharmacology.
2008 May; 54(6):998-1005. doi:
10.1016/j.neuropharm.2008.02.009. [PMID: 18359496] - T Martín-Jiménez, M Lindeblad, I M Kapetanovic, Y Chen, A Lyubimov. Comparing pharmacokinetic and pharmacodynamic profiles in female rats orally exposed to lovastatin by gavage versus diet.
Chemico-biological interactions.
2008 Jan; 171(2):142-51. doi:
10.1016/j.cbi.2007.07.010. [PMID: 17854789] - Mark J S Miller, Brian K Reuter, John L Wallace, Keith A Sharkey. A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.
Journal of translational medicine.
2008 Jan; 6(?):3. doi:
10.1186/1479-5876-6-3. [PMID: 18205911] - Shahar Lev-Ari, Dov Lichtenberg, Nadir Arber. Compositions for treatment of cancer and inflammation.
Recent patents on anti-cancer drug discovery.
2008 Jan; 3(1):55-62. doi:
10.2174/157489208783478720. [PMID: 18289124] - Akula Annapurna, Siva Reddy Challa, Gomedhikam J Prakash, Routhu Kasi Viswanath. Therapeutic potential of sulindac against ischemia-reperfusion-induced myocardial infarction in diabetic and nondiabetic rats.
Experimental and clinical cardiology.
2008; 13(2):66-70. doi:
. [PMID: 19343118] - Heath A Elrod, Shi-Yong Sun. PPARgamma and Apoptosis in Cancer.
PPAR research.
2008; 2008(?):704165. doi:
10.1155/2008/704165. [PMID: 18615184] - Keisuke Tachibana, Daisuke Yamasaki, Kenji Ishimoto, Takefumi Doi. The Role of PPARs in Cancer.
PPAR research.
2008; 2008(?):102737. doi:
10.1155/2008/102737. [PMID: 18584037] - Todd C Rideout, Scott V Harding, Peter Jh Jones, Ming Z Fan. Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: current understandings and future research priorities.
Vascular health and risk management.
2008; 4(5):1023-33. doi:
10.2147/vhrm.s3512. [PMID: 19183750] - Sandra Silva, José Maximino, Rui Henrique, Ana Paiva, Jorge Baldaia, Fernando Campilho, Pedro Pimentel, Alfredo Loureiro. Minimal change nephrotic syndrome after stem cell transplantation: a case report and literature review.
Journal of medical case reports.
2007 Oct; 1(?):121. doi:
10.1186/1752-1947-1-121. [PMID: 17971194] - Bhagavathi A Narayanan, Bandaru S Reddy, Maarten C Bosland, Dominick Nargi, Lori Horton, Carla Randolph, Narayanan K Narayanan. Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Oct; 13(19):5965-73. doi:
10.1158/1078-0432.ccr-07-0744. [PMID: 17908994] - Amichand Dairam, Adrienne C Müller, Santy Daya. Non-steroidal anti-inflammatory agents, tolmetin and sulindac attenuate quinolinic acid (QA)-induced oxidative stress in primary hippocampal neurons and reduce QA-induced spatial reference memory deficits in male Wistar rats.
Life sciences.
2007 Mar; 80(15):1431-8. doi:
10.1016/j.lfs.2007.01.006. [PMID: 17266991] - R D Verschoyle, P Greaves, H Cai, R E Edwards, W P Steward, A J Gescher. Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis.
British journal of cancer.
2007 Jan; 96(2):248-54. doi:
10.1038/sj.bjc.6603539. [PMID: 17211473] - Azza A K El-Sheikh, Jeroen J M W van den Heuvel, Jan B Koenderink, Frans G M Russel. Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport.
The Journal of pharmacology and experimental therapeutics.
2007 Jan; 320(1):229-35. doi:
10.1124/jpet.106.110379. [PMID: 17005917] - Gerd Bobe, Bing Wang, Navindra P Seeram, Muraleedharan G Nair, Leslie D Bourquin. Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac.
Journal of agricultural and food chemistry.
2006 Dec; 54(25):9322-8. doi:
10.1021/jf0612169. [PMID: 17147414] - I M Kapetanovic, R Krishnaraj, T Martin-Jimenez, L Yuan, R B van Breemen, A Lyubimov. Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics.
Chemico-biological interactions.
2006 Dec; 164(1-2):68-75. doi:
10.1016/j.cbi.2006.08.019. [PMID: 17027946] - Virginie Quidville, Nadine Segond, Sylvie Lausson, Melinee Frenkian, Regis Cohen, Annick Jullienne. 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line.
Prostaglandins & other lipid mediators.
2006 Oct; 81(1-2):14-30. doi:
10.1016/j.prostaglandins.2006.06.004. [PMID: 16997128] - Robert W Li, CongJun Li. Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells.
BMC genomics.
2006 Sep; 7(?):234. doi:
10.1186/1471-2164-7-234. [PMID: 16972989] - Mark F McCarty, Keith I Block. Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy.
Integrative cancer therapies.
2006 Sep; 5(3):252-68. doi:
10.1177/1534735406291499. [PMID: 16880431] - Amichand Dairam, Prakash Chetty, Santy Daya. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons.
Metabolic brain disease.
2006 Sep; 21(2-3):221-33. doi:
10.1007/s11011-006-9014-5. [PMID: 16850258] - Yen-Ling Chen, Yuh-Jyh Jong, Shou-Mei Wu. Capillary electrophoresis combining field-amplified sample stacking and electroosmotic flow suppressant for analysis of sulindac and its two metabolites in plasma.
Journal of chromatography. A.
2006 Jun; 1119(1-2):176-82. doi:
10.1016/j.chroma.2006.02.054. [PMID: 16530777] - Adriana Fernandes da Silva, Evandro Piva, Flávio Fernando Demarco, Lourenço Correr Sobrinho, Prudêncio Willy Rodo Osinga. Microleakage in conventional and bonded amalgam restorations: influence of cavity volume.
Operative dentistry.
2006 May; 31(3):377-83. doi:
10.2341/05-49. [PMID: 16802647] - Lawrence Levine. Cyclooxygenase expression is not required for release of arachidonic acid from cells by some nonsteroidal anti-inflammatory drugs and cancer preventive agents.
BMC pharmacology.
2006 Mar; 6(?):7. doi:
10.1186/1471-2210-6-7. [PMID: 16571133] - M N Kelly-Skupek, H R Irving. Pharmacological evidence for activation of phospholipid and small GTP binding protein signalling cascades by Nod factors.
Plant physiology and biochemistry : PPB.
2006 Feb; 44(2-3):132-42. doi:
10.1016/j.plaphy.2006.03.004. [PMID: 16647267] - Hadas Dvory-Sobol, Diana Kazanov, Eliezer Liberman, Shlomo Birkenfeld, Benny Bulvik, Pauline Luk, Moshe Leshno, Nadir Arber. MF tricyclic and sulindac retard tumor formation in an animal model.
International journal of cancer.
2006 Jan; 118(1):11-6. doi:
10.1002/ijc.21218. [PMID: 16003752] - Rainer Breitling, Patrick Armengaud, Anna Amtmann. Vector analysis as a fast and easy method to compare gene expression responses between different experimental backgrounds.
BMC bioinformatics.
2005 Jul; 6(?):181. doi:
10.1186/1471-2105-6-181. [PMID: 16029491] - T Lund, T Stokke, Ø E Olsen, Ø Fodstad. Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.
British journal of cancer.
2005 May; 92(9):1773-81. doi:
10.1038/sj.bjc.6602537. [PMID: 15827557] - Alvin M Malkinson. Role of inflammation in mouse lung tumorigenesis: a review.
Experimental lung research.
2005 Jan; 31(1):57-82. doi:
10.1080/01902140490495020. [PMID: 15765919] - Stanley G Wu, Edward P C Lai, Paul M Mayer. Molecularly imprinted solid phase extraction-pulsed elution-mass spectrometry for determination of cephalexin and alpha-aminocephalosporin antibiotics in human serum.
Journal of pharmaceutical and biomedical analysis.
2004 Nov; 36(3):483-90. doi:
10.1016/j.jpba.2003.05.001. [PMID: 15522521]