Thiolactomycin (BioDeep_00000008525)

   


代谢物信息卡片


(5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2-one

化学式: C11H14O2S (210.0714464)
中文名称: 乳霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C/C(=C/[C@]1(C)C(=O)C(=C(O)S1)C)/C
InChI: InChI=1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,12H,1H2,2-4H3/b7-6+/t11-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

2 个代谢物同义名

Thiolactomycin; (5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2-one



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Thomas Steinbrecher, David A Case, Andreas Labahn. Free energy calculations on the binding of novel thiolactomycin derivatives to E. coli fatty acid synthase I. Bioorganic & medicinal chemistry. 2012 Jun; 20(11):3446-53. doi: 10.1016/j.bmc.2012.04.019. [PMID: 22560835]
  • Patrik Johansson, Birgit Wiltschi, Preeti Kumari, Brigitte Kessler, Clemens Vonrhein, Janet Vonck, Dieter Oesterhelt, Martin Grininger. Inhibition of the fungal fatty acid synthase type I multienzyme complex. Proceedings of the National Academy of Sciences of the United States of America. 2008 Sep; 105(35):12803-8. doi: 10.1073/pnas.0805827105. [PMID: 18725634]
  • Günter Pappenberger, Tanja Schulz-Gasch, Eric Kusznir, Francis Müller, Michael Hennig. Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis. Acta crystallographica. Section D, Biological crystallography. 2007 Dec; 63(Pt 12):1208-16. doi: 10.1107/s0907444907049852. [PMID: 18084068]
  • A Lesley Jones, Andy M Gane, Derek Herbert, David L Willey, Andrew J Rutter, Peter Kille, Jane E Dancer, John L Harwood. Beta-ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme. Planta. 2003 Mar; 216(5):752-61. doi: 10.1007/s00425-002-0925-z. [PMID: 12624762]
  • Ross F Waller, Stuart A Ralph, Michael B Reed, Vanessa Su, James D Douglas, David E Minnikin, Alan F Cowman, Gurdyal S Besra, Geoffrey I McFadden. A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrobial agents and chemotherapy. 2003 Jan; 47(1):297-301. doi: 10.1128/aac.47.1.297-301.2003. [PMID: 12499205]
  • N M Parrish, T Houston, P B Jones, C Townsend, J D Dick. In vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis. Antimicrobial agents and chemotherapy. 2001 Apr; 45(4):1143-50. doi: 10.1128/aac.45.4.1143-1150.2001. [PMID: 11257028]
  • R A Slayden, R E Lee, C E Barry. Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis. Molecular microbiology. 2000 Nov; 38(3):514-25. doi: 10.1046/j.1365-2958.2000.02145.x. [PMID: 11069675]
  • P B Jones, N M Parrish, T A Houston, A Stapon, N P Bansal, J D Dick, C A Townsend. A new class of antituberculosis agents. Journal of medicinal chemistry. 2000 Aug; 43(17):3304-14. doi: 10.1021/jm000149l. [PMID: 10966749]
  • A L Jones, D Herbert, A J Rutter, J E Dancer, J L Harwood. Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum). The Biochemical journal. 2000 Apr; 347 Pt 1(?):205-9. doi: 10.1042/bj3470205. [PMID: 10727420]
  • B S Gulliver, A R Slabas. Acetoacyl-acyl carrier protein synthase from avocado: its purification, characterisation and clear resolution from acetyl CoA:ACP transacylase. Plant molecular biology. 1994 May; 25(2):179-91. doi: 10.1007/bf00023236. [PMID: 8018868]
  • T Noto, S Miyakawa, H Oishi, H Endo, H Okazaki. Thiolactomycin, a new antibiotic. III. In vitro antibacterial activity. The Journal of antibiotics. 1982 Apr; 35(4):401-10. doi: 10.7164/antibiotics.35.401. [PMID: 6980215]
  • S Miyakawa, K Suzuki, T Noto, Y Harada, H Okazaki. Thiolactomycin, a new antibiotic. IV. Biological properties and chemotherapeutic activity in mice. The Journal of antibiotics. 1982 Apr; 35(4):411-9. doi: 10.7164/antibiotics.35.411. [PMID: 7096196]