Gene Association: PHF8
UniProt Search:
PHF8 (PROTEIN_CODING)
Function Description: PHD finger protein 8
found 4 associated metabolites with current gene based on the text mining result from the pubmed database.
N(6)-Methyllysine
N(6)-Methyllysine is a naturally occurring amino acid found in human biofluids. N-monomethyl-lysine is generated by metabolic transmethylation of endogenous lysine. Lysine methylation displays the highest degree of complexity among known covalent histone modifications, with each site of methylation regulating the association of different effector molecules. The versatility of lysine methylation marks is perhaps best exemplified by modifications implicated in transcriptional regulation as well as being required for double-strand break repair in several organisms. Identification of the numerous biological functions encoded by histone lysine methylation is a major area of research interest, as these mechanisms are intimately associated with cellular senescence, genomic instability, and leukemogenesis. While multiple sites of lysine methylation have been linked with gene activation, each modification is distributed to unique positions across the active gene. (PMID: 17030614, 1122639, 15756599, 3111294). N(6)-Methyllysine is a naturally occurring amino acid found in human biofluids. N-monomethyl-lysine is generated by metabolic transmethylation of endogenous lysine.
Methionine sulfoximine
Methionine sulfoximine is found in flours treated with NCl3 as a produced of NCl3 action on wheat protein
L-Methionine sulfoximine
A methionine sulfoximine in which the amino group has S-stereochemistry.
N(6)-Methyllysine
A lysine derivative that is lysine in which one of the hydrogens attached to N(6) is substituted by a methyl group.
