carbinoxamine (BioDeep_00001868242)
Main id: BioDeep_00000001924
代谢物信息卡片
化学式: C16H19ClN2O (290.1186)
中文名称: 卡比沙明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
InChI: InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
描述信息
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
同义名列表
2 个代谢物同义名
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yaxin Deng, Tiantian Wang, Jinlong Li, Wanxiao Sun, Haibing He, Jingxin Gou, Yanjiao Wang, Tian Yin, Yu Zhang, Xing Tang. Studies on the in vitro ion exchange kinetics and thermodynamics and in vivo pharmacokinetics of the carbinoxamine-resin complex.
International journal of pharmaceutics.
2020 Oct; 588(?):119779. doi:
10.1016/j.ijpharm.2020.119779. [PMID: 32805380] - Yao-Te Yen, Yin-Jue Chang, Pin-Jung Lai, Chi-Lun Chang, Ting-Yueh Chen, San-Chong Chyueh. A Study of Opiate, Opiate Metabolites and Antihistamines in Urine after Consumption of Cold Syrups by LC-MS/MS.
Molecules (Basel, Switzerland).
2020 Feb; 25(4):. doi:
10.3390/molecules25040972. [PMID: 32098143] - Soha M El-Masry, Rasha M El-Morsi. Simple HPLC Method for Quantitative Determination of Carbinoxamine in Human Plasma: Application in Pharmacokinetic Studies and Therapeutic Drug Monitoring.
Drug research.
2019 Jun; 69(6):342-347. doi:
10.1055/a-0787-1302. [PMID: 30658353] - Pei Li, Jie Xiao, Jing Liu, Ran Liu, Kaishun Bi, Qing Li. Development and full validation of a liquid chromatography-tandem mass spectrometry method for determination of carbinoxamine in beagle plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1093-1094(?):183-189. doi:
10.1016/j.jchromb.2018.05.002. [PMID: 30032018] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Derong Zhu, Xia Li, Jinying Sun, Tianyan You. Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.
Talanta.
2012 Jan; 88(?):265-71. doi:
10.1016/j.talanta.2011.10.040. [PMID: 22265497] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - M A Martínez-Gómez, M M Carril-Avilés, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Characterization of antihistamine-human serum protein interactions by capillary electrophoresis.
Journal of chromatography. A.
2007 Apr; 1147(2):261-9. doi:
10.1016/j.chroma.2007.02.054. [PMID: 17339039] - A Stockis, X Deroubaix, B Jeanbaptiste, R Lins, A M Allemon, H Laufen. Relative bioavailability of carbinoxamine and phenylephrine from a retard capsule after single and repeated dose administration in healthy subjects.
Arzneimittel-Forschung.
1995 Sep; 45(9):1009-12. doi:
. [PMID: 7488301] - A Stockis, E Lebacq, X Deroubaix, A M Allemon, H Laufen. Relative bioavailability of carbinoxamine and phenylpropanolamine from a retard suspension after single dose administration in healthy subjects.
Arzneimittel-Forschung.
1992 Dec; 42(12):1478-81. doi:
. [PMID: 1363194] - D J Hoffman, M J Leveque, T Thomson. Capillary GLC assay for carbinoxamine and hydrocodone in human serum using nitrogen-sensitive detection.
Journal of pharmaceutical sciences.
1983 Nov; 72(11):1342-4. doi:
10.1002/jps.2600721126. [PMID: 6644600]
