aspoxicillin (BioDeep_00000009436)

   


代谢物信息卡片


aspoxicillin

化学式: C21H27N5O7S (493.16311120000006)
中文名称: 阿泊西西林
谱图信息: 最多检出来源 Astragalus membranaceus(plant) 50%

分子结构信息

SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)NC(=O)C(CC(=O)NC)N)C(=O)O)C
InChI: InChI=1S/C21H27N5O7S/c1-21(2)15(20(32)33)26-18(31)14(19(26)34-21)25-17(30)13(9-4-6-10(27)7-5-9)24-16(29)11(22)8-12(28)23-3/h4-7,11,13-15,19,27H,8,22H2,1-3H3,(H,23,28)(H,24,29)(H,25,30)(H,32,33)/t11-,13-,14-,15+,19-/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Same as: D07469

同义名列表

2 个代谢物同义名

aspoxicillin; Aspoxicillin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Kurokawa, S Suzuki, K Matsuda, A Nakamura, Y Matsushita, A K Kitahara, H Aoki, M Ota, K Takaba, M Naito. [Studies on aspoxicillin for its transfer to the skin]. The Japanese journal of antibiotics. 1994 Feb; 47(2):215-8. doi: NULL. [PMID: 8151914]
  • K Nakai, T Tokushima, Y Hirota, M Nagamatsu, K Takeda, M Mizobe, C Takai. [Pharmacokinetic study on aspoxicillin transfer into pulmonary and tracheal tissues]. The Japanese journal of antibiotics. 1993 May; 46(5):367-73. doi: NULL. [PMID: 8326676]
  • H Nishi, T Fukuyama, M Matsuo. Separation and determination of aspoxicillin in human plasma by micellar electrokinetic chromatography with direct sample injection. Journal of chromatography. 1990 Aug; 515(?):245-55. doi: 10.1016/s0021-9673(01)89319-5. [PMID: 2283365]
  • T Oshida, T Onta, N Nakanishi, T Matsushita, T Yamaguchi. Activity of sub-minimal inhibitory concentrations of aspoxicillin in prolonging the postantibiotic effect against Staphylococcus aureus. The Journal of antimicrobial chemotherapy. 1990 Jul; 26(1):29-38. doi: 10.1093/jac/26.1.29. [PMID: 2211444]
  • J Geyer, D Höffler, P Koeppe. Pharmacokinetics of aspoxicillin in subjects with normal and impaired renal function. Arzneimittel-Forschung. 1988 Nov; 38(11):1635-9. doi: . [PMID: 3214450]
  • S Okuno, I Maezawa, Y Sakuma, T Matsushita, T Yamaguchi. Effect of the hydroxyl group of the p-hydroxyphenyl moiety of aspoxicillin, a semisynthetic penicillin, on its pharmacokinetic property. The Journal of antibiotics. 1988 Feb; 41(2):239-46. doi: 10.7164/antibiotics.41.239. [PMID: 3356612]
  • S Arakawa, T Matsui, H Maeda, M Sako, M Sugino, S Ka, T Nakasuji, A Fujii, S Kamidono, I Maezawa. [Pharmacokinetics and urinary excretion of aspoxicillin after consecutive administration at a dose of 4 grams]. The Japanese journal of antibiotics. 1988 Jan; 41(1):37-47. doi: NULL. [PMID: 3367513]
  • R Fujii, H Meguro, B Kim, H Yonezawa, T Kawaoi, T Tajima, J Mashiko, S Nakazawa, K Niino, H Sato. [Pharmacokinetics and clinical effects of aspoxicillin in pediatric patients]. The Japanese journal of antibiotics. 1987 Sep; 40(9):1651-67. doi: . [PMID: 3694789]
  • K Matsumoto. [Review: New antimicrobial agent series XXII: Aspoxicillin]. The Japanese journal of antibiotics. 1987 Jul; 40(7):1221-42. doi: . [PMID: 3316732]
  • J Knöller, W Schönfeld, K D Bremm, W König. Determination of aspoxicillin (TA-058) by high-performance liquid chromatography. Stability at different temperatures. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. 1987 Jun; 265(1-2):176-81. doi: 10.1016/s0176-6724(87)80164-5. [PMID: 3673331]
  • K Matsumoto, H Shishido, Y Uzuka, T Nagatake, M Yamamoto, Y Sakuma, I Maezawa, T Yamaguchi. [Safety and pharmacology of aspoxicillin in healthy volunteers]. The Japanese journal of antibiotics. 1985 Oct; 38(10):2699-715. doi: . [PMID: 4078992]
  • S Nakazawa, H Sato, K Niino, Y Nakada. [Studies on the intravenous administration of aspoxicillin in the pediatric field]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1827-34. doi: . [PMID: 3851857]
  • S Ueda, F Hayakawa, T Nakashima, Y Miyachi, T Hakamada, K Kuno. [Laboratory and clinical studies on aspoxicillin in the field of pediatrics]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1853-67. doi: . [PMID: 3851859]
  • N Iwai, Y Taneda, M Shibata, F Mizoguchi, H Nakamura, M Katayama. [Fundamental and clinical studies on aspoxicillin in the pediatric field]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1868-81. doi: . [PMID: 3851860]
  • B Kim, H Meguro, J Mashiko, H Yonezawa, T Kawaoi, T Tajima, R Fujii. [Clinical evaluation of a new parenteral penicillin, aspoxicillin, in children]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1835-45. doi: . [PMID: 4068222]
  • H Wakiguchi, A Maeda, Y Ohara, Y Tone, K Araki, T Shiraishi, H Ogura, I Kitamura. [The therapeutic effects of aspoxicillin on various infectious diseases in children]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1925-30. doi: . [PMID: 4068226]
  • T Motohiro, A Kawakami, K Tanaka, T Koga, Y Shimada, N Tomita, Y Sakata, T Fujimoto, T Nishiyama, K Tominaga. [Fundamental and clinical studies of aspoxicillin in the pediatric field]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1951-71. doi: . [PMID: 4068228]
  • T Sato, K Ueda, T Kuroiwa. [A clinical evaluation of aspoxicillin in children]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1944-50. doi: . [PMID: 4068227]
  • T Nishimura, K Tabuki, T Takashima, M Takagi. [Clinical and laboratory evaluation of aspoxicillin in the pediatric field]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1889-97. doi: . [PMID: 3851861]
  • T Matsushita, K Kouyama, T Yamaguchi. [Bactericidal activity of aspoxicillin in an in vitro model simulating human serum levels]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1819-26. doi: NULL. [PMID: 3906168]
  • N Nakayama, M Yanagishima, K Tomimasu, Y Tsuji. [Clinical evaluation of aspoxicillin in children]. The Japanese journal of antibiotics. 1985 Jul; 38(7):1972-8. doi: NULL. [PMID: 4068229]
  • H Tsuburaya, I Watanabe, M Takahashi, S Endo. [A clinical study on the penetration of aspoxicillin into tissue and wound exudates in breast cancer]. The Japanese journal of antibiotics. 1985 Jun; 38(6):1509-15. doi: NULL. [PMID: 4046174]