Chemical Formula: C26H42N7O20P3S

Chemical Formula C26H42N7O20P3S

Found 20 metabolite its formula value is C26H42N7O20P3S

Citramalyl-CoA

L-Citramalyl-CoA

C26H42N7O20P3S (897.1418)


An acyl-CoA having citramalyl as the S-acyl group.

   

2-Hydroxyglutaryl-CoA

2-Hydroxyglutaryl-CoA

C26H42N7O20P3S (897.1418)


A hydroxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-hydroxyglutaric acid.

   

beta-methylmalyl-CoA

PubChem CID: 25246206; (Acyl-CoA); [M+H]+;

C26H42N7O20P3S (897.1418)


   

L-Citramalyl-CoA

(2S)-4-({2-[(3-{[(2R)-4-({[({[(2R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-1,2-dihydroxy-3,3-dimethylbutylidene]amino}-1-hydroxypropylidene)amino]ethyl}sulphanyl)-2-hydroxy-2-methyl-4-oxobutanoic acid

C26H42N7O20P3S (897.1418)


L-Citramalyl-CoA is an intermediate in C5-Branched dibasic acid metabolism. L-Citramalyl-CoA is the 3rd to last step in the synthesis of (R)-Acetoin and is converted from L-Citramalate via the enzyme citramalate CoA-transferase (EC 2.8.3.7). It is then converted to Pyruvate via the enzyme citramalate-CoA lyase (EC 4.1.3.25). [HMDB] L-Citramalyl-CoA is an intermediate in C5-Branched dibasic acid metabolism. L-Citramalyl-CoA is the 3rd to last step in the synthesis of (R)-Acetoin and is converted from L-Citramalate via the enzyme citramalate CoA-transferase (EC 2.8.3.7). It is then converted to Pyruvate via the enzyme citramalate-CoA lyase (EC 4.1.3.25).

   

(3R)-citramalyl-CoA

(3R)-citramalyl-CoA

C26H42N7O20P3S (897.1418)


The (3R)-diastereomer of citramalyl-CoA.

   

2-hydroxy-3-methylbutanedioyl-CoA

4-({2-[(3-{[4-({[({[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-1,2-dihydroxy-3,3-dimethylbutylidene]amino}-1-hydroxypropylidene)amino]ethyl}sulphanyl)-2-hydroxy-3-methyl-4-oxobutanoic acid

C26H42N7O20P3S (897.1418)


2-hydroxy-3-methylbutanedioyl-coa is an acyl-CoA or acyl-coenzyme A. More specifically, it is a 2-hydroxy-3-methylbutanedioic acid thioester of coenzyme A. 2-hydroxy-3-methylbutanedioyl-coa is an acyl-CoA with 5 fatty acid group as the acyl moiety attached to coenzyme A. Coenzyme A was discovered in 1946 by Fritz Lipmann (Journal of Biological Chemistry (1946) 162 (3): 743–744) and its structure was determined in the early 1950s at the Lister Institute in London. Coenzyme A is a complex, thiol-containing molecule that is naturally synthesized from pantothenate (vitamin B5), which is found in various foods such as meat, vegetables, cereal grains, legumes, eggs, and milk. More specifically, coenzyme A (CoASH or CoA) consists of a beta-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3-phosphorylated ADP. Coenzyme A is synthesized in a five-step process that requires four molecules of ATP, pantothenate and cysteine. It is believed that there are more than 1100 types of acyl-CoA’s in the human body, which also corresponds to the number of acylcarnitines in the human body. Acyl-CoAs exists in all living species, ranging from bacteria to plants to humans. The general role of acyl-CoA’s is to assist in transferring fatty acids from the cytoplasm to mitochondria. This process facilitates the production of fatty acids in cells, which are essential in cell membrane structure. Acyl-CoAs are also susceptible to beta oxidation, forming, ultimately, acetyl-CoA. Acetyl-CoA can enter the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP -- or biochemical energy. Acyl-CoAs can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain acyl-CoAs; 2) medium-chain acyl-CoAs; 3) long-chain acyl-CoAs; and 4) very long-chain acyl-CoAs; 5) hydroxy acyl-CoAs; 6) branched chain acyl-CoAs; 7) unsaturated acyl-CoAs; 8) dicarboxylic acyl-CoAs and 9) miscellaneous acyl-CoAs. Short-chain acyl-CoAs have acyl-groups with two to four carbons (C2-C4), medium-chain acyl-CoAs have acyl-groups with five to eleven carbons (C5-C11), long-chain acyl-CoAs have acyl-groups with twelve to twenty carbons (C12-C20) while very long-chain acyl-CoAs have acyl groups with more than 20 carbons. 2-hydroxy-3-methylbutanedioyl-coa is therefore classified as a medium chain acyl-CoA. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase/synthase. Fatty acids are first converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase. Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. 2-hydroxy-3-methylbutanedioyl-coa, being a medium chain acyl-CoA is a substrate for medium chain acyl-CoA synthase. The second step of fatty acid degradation is beta oxidation. Beta oxidation occurs in mitochondria and, in the case of very long chain acyl-CoAs, the peroxisome. After its formation in the cytosol, 2-hydroxy-3-methylbutanedioyl-CoA is transported into the mitochondria, the locus of beta oxidation. Transport of 2-hydroxy-3-methylbutanedioyl-CoA into the mitochondria requires carnitine palmitoyltransferase 1 (CPT1), which converts 2-hydroxy-3-methylbutanedioyl-CoA into 2-hydroxy-3-methylbutanedioylcarnitine, which gets transported into the mitochondrial matrix. Once in the matrix, 2-hydroxy-3-methylbutanedioylcarnitine is converted back to 2-hydroxy-3-methylbutanedioyl-CoA by CPT2, whereupon beta-oxidation can begin. Beta oxidation of 2-hydroxy-3-methylbutanedioyl-CoA occurs in four steps. First, since 2-hydroxy-3-methylbutanedioyl-CoA is a medium chain acyl-CoA it is the substrate for a medium chain acyl-CoA dehydrogenase, which catalyzes dehydrogenation of 2-hydroxy-3-methylbutanedioyl-CoA, creating a double bond between the alpha and beta carbons. FAD is the hydrogen acceptor, yielding FADH2. Second, Enoyl-C...

   

CoA 5:1;O3

3-phosphoadenosine 5-{3-[(3R)-4-({3-[(2-{[(3S)-3-carboxy-3-hydroxybutanoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}

C26H42N7O20P3S (897.1418)


   

2-Hydroxyglutaryl-1-coenzyme A

2-Hydroxyglutaryl-1-coenzyme A

C26H42N7O20P3S (897.1418)


   

3-Hydroxyglutaryl-coenzyme A

3-Hydroxyglutaryl-coenzyme A

C26H42N7O20P3S (897.1418)


   

5-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-2-hydroxy-5-oxopentanoic acid

5-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-2-hydroxy-5-oxopentanoic acid

C26H42N7O20P3S (897.1418)


   

(3r,5s,9r,21s)-1-[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-4-Hydroxy-3-(Phosphonooxy)tetrahydrofuran-2-Yl]-3,5,9,21-Tetrahydroxy-8,8-Dimethyl-10,14,19-Trioxo-2,4,6-Trioxa-18-Thia-11,15-Diaza-3,5-Diphosphatricosan-23-Oic Acid 3,5-Dioxide

(3r,5s,9r,21s)-1-[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-4-Hydroxy-3-(Phosphonooxy)tetrahydrofuran-2-Yl]-3,5,9,21-Tetrahydroxy-8,8-Dimethyl-10,14,19-Trioxo-2,4,6-Trioxa-18-Thia-11,15-Diaza-3,5-Diphosphatricosan-23-Oic Acid 3,5-Dioxide

C26H42N7O20P3S (897.1418)


   

Citramalyl-CoA; (Acyl-CoA); [M+H]+

Citramalyl-CoA; (Acyl-CoA); [M+H]+

C26H42N7O20P3S (897.1418)


   

CID3514895; (Acyl-CoA); [M+H]+

CID3514895; (Acyl-CoA); [M+H]+

C26H42N7O20P3S (897.1418)


   

2-Hydroxyglutaryl-CoA; (Acyl-CoA); [M+H]+

2-Hydroxyglutaryl-CoA; (Acyl-CoA); [M+H]+

C26H42N7O20P3S (897.1418)


   

L-erythro-3-Methylmalyl-CoA; (Acyl-CoA); [M+H]+

L-erythro-3-Methylmalyl-CoA; (Acyl-CoA); [M+H]+

C26H42N7O20P3S (897.1418)


   

PubChem CID: 25246072; (Acyl-CoA); [M+H]+

PubChem CID: 25246072; (Acyl-CoA); [M+H]+

C26H42N7O20P3S (897.1418)


   

(3S)-citramalyl-CoA

(3S)-citramalyl-CoA

C26H42N7O20P3S (897.1418)


The (3S)-diastereomer of citramalyl-CoA.

   

(R)-2-hydroxyglutaryl-CoA

(R)-2-hydroxyglutaryl-CoA

C26H42N7O20P3S (897.1418)


A hydroxyglutaryl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (R)-2-hydroxyglutaric acid.

   

L-erythro-3-methylmalyl-CoA

L-erythro-3-methylmalyl-CoA

C26H42N7O20P3S (897.1418)


A hydroxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of L-erythro-3-methylmalic acid.