3-Amino-4-[(1-benzyl-2-methoxy-2-oxoethyl)amino]-4-oxobutanoic acid (BioDeep_00001883574)

   


代谢物信息卡片


3-Amino-4-[(1-benzyl-2-methoxy-2-oxoethyl)amino]-4-oxobutanoic acid

化学式: C14H18N2O5 (294.1215658)
中文名称: 3-氨基-4-[(1-苄基-2-甲氧基-2-氧代乙基)氨基]-4-氧代丁酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)

描述信息

D000074385 - Food Ingredients > D005503 - Food Additives
D010592 - Pharmaceutic Aids > D005421 - Flavoring Agents

同义名列表

1 个代谢物同义名

3-Amino-4-[(1-benzyl-2-methoxy-2-oxoethyl)amino]-4-oxobutanoic acid



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Emmanuella Enuwosa, Lata Gautam, Linda King, Havovi Chichger. Saccharin and Sucralose Protect the Glomerular Microvasculature In Vitro against VEGF-Induced Permeability. Nutrients. 2021 Aug; 13(8):. doi: 10.3390/nu13082746. [PMID: 34444906]
  • Hojat Anbara, Mohammad Taghi Sheibani, Mazdak Razi, Mehdi Kian. Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model. Environmental toxicology. 2021 Feb; 36(2):223-237. doi: 10.1002/tox.23028. [PMID: 32951320]
  • Shimaa Anter Fareed, Heba El-Sayed Mostafa. Could aspartame exacerbate caffeine effects on renal maturation in rat's offspring? A biochemical and histological study. Birth defects research. 2021 01; 113(1):90-107. doi: 10.1002/bdr2.1836. [PMID: 33128303]
  • Fahimeh Kheirdoosh, Soheila Kashanian, Mohammad Mehdi Khodaei, Mahya Sariaslani, Monireh Falsafi, Neda Hosseinpour Moghadam, Sadegh Salehzadeh, Mahsa Pazhavand, Mahdi Kashanian. Spectroscopic studies on the interaction of aspartame with human serum albumin. Nucleosides, nucleotides & nucleic acids. 2021; 40(3):300-316. doi: 10.1080/15257770.2021.1872792. [PMID: 33455539]
  • Samar Y Ahmad, James Friel, Dylan Mackay. The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial. Nutrients. 2020 Nov; 12(11):. doi: 10.3390/nu12113408. [PMID: 33171964]
  • Bettina Hieronimus, Valentina Medici, Andrew A Bremer, Vivien Lee, Marinelle V Nunez, Desiree M Sigala, Nancy L Keim, Peter J Havel, Kimber L Stanhope. Synergistic effects of fructose and glucose on lipoprotein risk factors for cardiovascular disease in young adults. Metabolism: clinical and experimental. 2020 11; 112(?):154356. doi: 10.1016/j.metabol.2020.154356. [PMID: 32916151]
  • Nathaniel H O Harder, Bettina Hieronimus, Kimber L Stanhope, Noreene M Shibata, Vivien Lee, Marinelle V Nunez, Nancy L Keim, Andrew Bremer, Peter J Havel, Marie C Heffern, Valentina Medici. Effects of Dietary Glucose and Fructose on Copper, Iron, and Zinc Metabolism Parameters in Humans. Nutrients. 2020 Aug; 12(9):. doi: 10.3390/nu12092581. [PMID: 32854403]
  • Concetta Schiano, Vincenzo Grimaldi, Monica Franzese, Carmela Fiorito, Filomena De Nigris, Francesco Donatelli, Andrea Soricelli, Marco Salvatore, Claudio Napoli. Non-nutritional sweeteners effects on endothelial vascular function. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Feb; 62(?):104694. doi: 10.1016/j.tiv.2019.104694. [PMID: 31655124]
  • Daming Sun, Lixiang Liu, Shengyong Mao, Weiyun Zhu, Junhua Liu. Aspartame supplementation in starter accelerates small intestinal epithelial cell cycle and stimulates secretion of glucagon-like peptide-2 in pre-weaned lambs. Journal of animal physiology and animal nutrition. 2019 Sep; 103(5):1338-1350. doi: 10.1111/jpn.13159. [PMID: 31342562]
  • Hideaki Kashima, Kana Taniyama, Kana Sugimura, Masako Yamaoka Endo, Toshio Kobayashi, Yoshiyuki Fukuba. Suppression of sweet sensing with glucose, but not aspartame, delays gastric emptying and glycemic response. Nutrition research (New York, N.Y.). 2019 08; 68(?):62-69. doi: 10.1016/j.nutres.2019.06.005. [PMID: 31421394]
  • Kelly A Higgins, Richard D Mattes. A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. The American journal of clinical nutrition. 2019 05; 109(5):1288-1301. doi: 10.1093/ajcn/nqy381. [PMID: 30997499]
  • Nomcebo Mchunu, Chika Ifeanyi Chukwuma, Mohammed Auwal Ibrahim, Olajumoke A Oyebode, Siphiwe Ndumiso Dlamini, Md Shahidul Islam. Commercially available non-nutritive sweeteners modulate the antioxidant status of type 2 diabetic rats. Journal of food biochemistry. 2019 03; 43(3):e12775. doi: 10.1111/jfbc.12775. [PMID: 31353552]
  • Yusuke Shibui, Shoji Fujitani, Hijiri Iwata, Barry Lynch, Ashley Roberts. Histological analyses of the Ishii (1981) rat carcinogenicity study of aspartame and comparison with the Ramazzini Institute studies. Regulatory toxicology and pharmacology : RTP. 2019 Mar; 102(?):23-29. doi: 10.1016/j.yrtph.2018.12.010. [PMID: 30572082]
  • Arbind Kumar Choudhary, Yeong Yeh Lee. The debate over neurotransmitter interaction in aspartame usage. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2018 Oct; 56(?):7-15. doi: 10.1016/j.jocn.2018.06.043. [PMID: 30318075]
  • Candice Allister Price, Donovan A Argueta, Valentina Medici, Andrew A Bremer, Vivien Lee, Marinelle V Nunez, Guoxia X Chen, Nancy L Keim, Peter J Havel, Kimber L Stanhope, Nicholas V DiPatrizio. Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage. American journal of physiology. Endocrinology and metabolism. 2018 08; 315(2):E141-E149. doi: 10.1152/ajpendo.00406.2017. [PMID: 29634315]
  • Arbind Kumar Choudhary, Yeong Yeh Lee. Neurophysiological symptoms and aspartame: What is the connection?. Nutritional neuroscience. 2018 Jun; 21(5):306-316. doi: 10.1080/1028415x.2017.1288340. [PMID: 28198207]
  • Kelly A Higgins, Robert V Considine, Richard D Mattes. Aspartame Consumption for 12 Weeks Does Not Affect Glycemia, Appetite, or Body Weight of Healthy, Lean Adults in a Randomized Controlled Trial. The Journal of nutrition. 2018 04; 148(4):650-657. doi: 10.1093/jn/nxy021. [PMID: 29659969]
  • Natalia Cardoso Santos, Laiza Magalhaes de Araujo, Graziela De Luca Canto, Eliete Neves Silva Guerra, Michella Soares Coelho, Maria de Fatima Borin. Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials. Critical reviews in food science and nutrition. 2018; 58(12):2068-2081. doi: 10.1080/10408398.2017.1304358. [PMID: 28394643]
  • Rasha A Al-Eisa, Fawziah A Al-Salmi, Reham Z Hamza, Nahla S El-Shenawy. Role of L-carnitine in protection against the cardiac oxidative stress induced by aspartame in Wistar albino rats. PloS one. 2018; 13(11):e0204913. doi: 10.1371/journal.pone.0204913. [PMID: 30403670]
  • Tomonori Kimura, Akane Kanasaki, Noriko Hayashi, Takako Yamada, Tetsuo Iida, Yasuo Nagata, Kazuhiro Okuma. d-Allulose enhances postprandial fat oxidation in healthy humans. Nutrition (Burbank, Los Angeles County, Calif.). 2017 Nov; 43-44(?):16-20. doi: 10.1016/j.nut.2017.06.007. [PMID: 28935140]
  • Muthuraman Pandurangan, Gansukh Enkhtaivan, Muthuviveganandavel Veerappan, Bhupendra Mistry, Rahul Patel, So Hyun Moon, Patnamsetty Chidanandha Nagajyothi, Doo Hwan Kim. Renal-protective and ameliorating impacts of omega-3 fatty acids against aspartame damaged MDCK cells. BioFactors (Oxford, England). 2017 Nov; 43(6):847-857. doi: 10.1002/biof.1387. [PMID: 28881099]
  • Mohammad Reza Ardalan, Hadi Tabibi, Vahideh Ebrahimzadeh Attari, Aida Malek Mahdavi. Nephrotoxic Effect of Aspartame as an Artificial Sweetener: a Brief Review. Iranian journal of kidney diseases. 2017 Oct; 11(5):339-343. doi: . [PMID: 29038387]
  • Mohamed A Lebda, Kadry M Sadek, Yasser S El-Sayed. Aspartame and Soft Drink-Mediated Neurotoxicity in Rats: Implication of Oxidative Stress, Apoptotic Signaling Pathways, Electrolytes and Hormonal Levels. Metabolic brain disease. 2017 10; 32(5):1639-1647. doi: 10.1007/s11011-017-0052-y. [PMID: 28660358]
  • Arbind Kumar Choudhary, Etheresia Pretorius. Revisiting the safety of aspartame. Nutrition reviews. 2017 Sep; 75(9):718-730. doi: 10.1093/nutrit/nux035. [PMID: 28938797]
  • Mohamed A Lebda, Hossam G Tohamy, Yasser S El-Sayed. Long-term soft drink and aspartame intake induces hepatic damage via dysregulation of adipocytokines and alteration of the lipid profile and antioxidant status. Nutrition research (New York, N.Y.). 2017 May; 41(?):47-55. doi: 10.1016/j.nutres.2017.04.002. [PMID: 28465000]
  • Isabela Finamor, Salvador Pérez, Caroline A Bressan, Carlos E Brenner, Sergio Rius-Pérez, Patricia C Brittes, Gabriele Cheiran, Maria I Rocha, Marcelo da Veiga, Juan Sastre, Maria A Pavanato. Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice. Redox biology. 2017 04; 11(?):701-707. doi: 10.1016/j.redox.2017.01.019. [PMID: 28187322]
  • Tao Zhang, Zhiwei Gan, Chuanzi Gao, Ling Ma, Yanxi Li, Xiao Li, Hongwen Sun. Occurrence of artificial sweeteners in human liver and paired blood and urine samples from adults in Tianjin, China and their implications for human exposure. Environmental science. Processes & impacts. 2016 Sep; 18(9):1169-76. doi: 10.1039/c6em00130k. [PMID: 27383923]
  • Oluwatosin A Adaramoye, Olubukola O Akanni. Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats. Journal of basic and clinical physiology and pharmacology. 2016 Jan; 27(1):29-37. doi: 10.1515/jbcpp-2014-0130. [PMID: 26247507]
  • Gun-Dong Kim, Yong Seek Park, Hyun-Jong Ahn, Jeong-Je Cho, Cheung-Seog Park. Aspartame Attenuates 2, 4-Dinitrofluorobenzene-Induced Atopic Dermatitis-Like Clinical Symptoms in NC/Nga Mice. The Journal of investigative dermatology. 2015 Nov; 135(11):2705-2713. doi: 10.1038/jid.2015.234. [PMID: 26099025]
  • Cara L Frankenfeld, Masoumeh Sikaroodi, Evan Lamb, Sarah Shoemaker, Patrick M Gillevet. High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Annals of epidemiology. 2015 Oct; 25(10):736-42.e4. doi: 10.1016/j.annepidem.2015.06.083. [PMID: 26272781]
  • Mohamed El-Sayed Alkafafy, Zein Shaban Ibrahim, Mohamed Mohamed Ahmed, Samir Ahmed El-Shazly. Impact of aspartame and saccharin on the rat liver: Biochemical, molecular, and histological approach. International journal of immunopathology and pharmacology. 2015 Jun; 28(2):247-55. doi: 10.1177/0394632015586134. [PMID: 26015492]
  • Arbind Kumar Choudhary, Rathinasamy Sheela Devi. Longer period of oral administration of aspartame on cytokine response in Wistar albino rats. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. 2015 Mar; 62(3):114-22. doi: 10.1016/j.endonu.2014.11.004. [PMID: 25681123]
  • Thozhukat Sathyapalan, Natalie J Thatcher, Richard Hammersley, Alan S Rigby, Fraser L Courts, Alexandros Pechlivanis, Nigel J Gooderham, Elaine Holmes, Carel W le Roux, Stephen L Atkin. Aspartame sensitivity? A double blind randomised crossover study. PloS one. 2015; 10(3):e0116212. doi: 10.1371/journal.pone.0116212. [PMID: 25786106]
  • Allison C Sylvetsky, Alexandra L Gardner, Viviana Bauman, Jenny E Blau, H Martin Garraffo, Peter J Walter, Kristina I Rother. Nonnutritive Sweeteners in Breast Milk. Journal of toxicology and environmental health. Part A. 2015; 78(16):1029-32. doi: 10.1080/15287394.2015.1053646. [PMID: 26267522]
  • Armorel Diane van Eyk. The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells. Drug and chemical toxicology. 2015; 38(3):318-27. doi: 10.3109/01480545.2014.966381. [PMID: 25317478]
  • Marko D Prokic, Milica G Paunovic, Milos M Matic, Natasa Z Djordjevic, Branka I Ognjanovic, Andras S Stajn, Zorica S Saicic. Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats. Journal of biosciences. 2014 Dec; 39(5):859-66. doi: 10.1007/s12038-014-9487-z. [PMID: 25431414]
  • Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal, Eran Elinav. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct; 514(7521):181-6. doi: 10.1038/nature13793. [PMID: 25231862]
  • Erik Norén, Henrik Forssell. Very low calorie diet without aspartame in obese subjects: improved metabolic control after 4 weeks treatment. Nutrition journal. 2014 Jul; 13(?):77. doi: 10.1186/1475-2891-13-77. [PMID: 25069603]
  • Nahid Shahabadi, Mohammad Mehdi Khodaei, Soheila Kashanian, Fahimeh Kheirdoosh, Soraya Moradi Filli. Study on the interaction of a copper(II) complex containing the artificial sweetener aspartame with human serum albumin. Molecular biology reports. 2014 May; 41(5):3271-8. doi: 10.1007/s11033-014-3189-3. [PMID: 24481880]
  • Marie Reid, Richard Hammersley, Maresa Duffy, Carrie Ballantyne. Effects on obese women of the sugar sucrose added to the diet over 28 d: a quasi-randomised, single-blind, controlled trial. The British journal of nutrition. 2014 Feb; 111(3):563-70. doi: 10.1017/s0007114513002687. [PMID: 24164779]
  • Maria-Cristina Radulescu, Bogdan Bucur, Madalina-Petruta Bucur, Gabriel Lucian Radu. Bienzymatic biosensor for rapid detection of aspartame by flow injection analysis. Sensors (Basel, Switzerland). 2014 Jan; 14(1):1028-38. doi: 10.3390/s140101028. [PMID: 24412899]
  • Marie S A Palmnäs, Theresa E Cowan, Marc R Bomhof, Juliet Su, Raylene A Reimer, Hans J Vogel, Dustin S Hittel, Jane Shearer. Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PloS one. 2014; 9(10):e109841. doi: 10.1371/journal.pone.0109841. [PMID: 25313461]
  • Marina Marinovich, Corrado L Galli, Cristina Bosetti, Silvano Gallus, Carlo La Vecchia. Aspartame, low-calorie sweeteners and disease: regulatory safety and epidemiological issues. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Oct; 60(?):109-15. doi: 10.1016/j.fct.2013.07.040. [PMID: 23891579]
  • Omar M E Abdel-Salam, Neveen A Salem, Jihan Seid Hussein. Effect of aspartame on oxidative stress and monoamine neurotransmitter levels in lipopolysaccharide-treated mice. Neurotoxicity research. 2012 Apr; 21(3):245-55. doi: 10.1007/s12640-011-9264-9. [PMID: 21822758]
  • Jae-Yong Kim, Juyi Seo, Kyung-Hyun Cho. Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Nov; 49(11):2899-905. doi: 10.1016/j.fct.2011.08.001. [PMID: 21855599]
  • Robert E Steinert, Florian Frey, Antonia Töpfer, Jürgen Drewe, Christoph Beglinger. Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides. The British journal of nutrition. 2011 May; 105(9):1320-8. doi: 10.1017/s000711451000512x. [PMID: 21255472]
  • Annemiek M C P Joosen, Gunter G C Kuhnle, Sue M Aspinall, Timothy M Barrow, Emmanuelle Lecommandeur, Amaya Azqueta, Andrew R Collins, Sheila A Bingham. Effect of processed and red meat on endogenous nitrosation and DNA damage. Carcinogenesis. 2009 Aug; 30(8):1402-7. doi: 10.1093/carcin/bgp130. [PMID: 19498009]
  • Sherman M Chamberlain, J Carter Balart, Kostas Sideridis, Jefrey Salek, Subbaramiah Sridhar, William O Thompson. Safety and efficacy of aspartame-based liquid versus sucrose-based liquids used for dilution in oral sodium phosphate solutions for colonoscopy preparations. Digestive diseases and sciences. 2007 Nov; 52(11):3165-8. doi: 10.1007/s10620-007-9790-8. [PMID: 17406813]
  • Irene Simintzi, Kleopatra H Schulpis, Panagoula Angelogianni, Charis Liapi, Stylianos Tsakiris. The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats. Pharmacological research. 2007 Aug; 56(2):155-9. doi: 10.1016/j.phrs.2007.05.003. [PMID: 17580119]
  • B A Magnuson, G A Burdock, J Doull, R M Kroes, G M Marsh, M W Pariza, P S Spencer, W J Waddell, R Walker, G M Williams. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Critical reviews in toxicology. 2007; 37(8):629-727. doi: 10.1080/10408440701516184. [PMID: 17828671]
  • Katalin Gombos, Tímea Varjas, Zsuzsanna Orsós, Eva Polyák, Judit Peredi, Zsuzsanna Varga, Ghodratollah Nowrasteh, Antal Tettinger, Gyula Mucsi, István Ember. The effect of aspartame administration on oncogene and suppressor gene expressions. In vivo (Athens, Greece). 2007 Jan; 21(1):89-92. doi: . [PMID: 17354619]
  • Randall Bennett, Bobbi Adams, Amanda French, Yasmin Neggers, John B Vincent. High-dose chromium(III) supplementation has no effects on body mass and composition while altering plasma hormone and triglycerides concentrations. Biological trace element research. 2006 Oct; 113(1):53-66. doi: 10.1385/bter:113:1:53. [PMID: 17114815]
  • Eric D B Goulet, Robert A Robergs, Susan Labrecque, Donald Royer, Isabelle J Dionne. Effect of glycerol-induced hyperhydration on thermoregulatory and cardiovascular functions and endurance performance during prolonged cycling in a 25 degrees C environment. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2006 Apr; 31(2):101-9. doi: 10.1139/h05-006. [PMID: 16604127]
  • Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti, Luca Lambertini, Eva Tibaldi, Anna Rigano. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environmental health perspectives. 2006 Mar; 114(3):379-85. doi: 10.1289/ehp.8711. [PMID: 16507461]
  • Karen Lau, W Graham McLean, Dominic P Williams, C Vyvyan Howard. Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicological sciences : an official journal of the Society of Toxicology. 2006 Mar; 90(1):178-87. doi: 10.1093/toxsci/kfj073. [PMID: 16352620]
  • M Nathaniel Mead. Sour finding on popular sweetener. Environmental health perspectives. 2006 Mar; 114(3):A176. doi: 10.1289/ehp.114-a176a. [PMID: 16528837]
  • NULL. [Sweetening agent aspartame as carcinogen?]. Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege. 2006 Feb; 25(2):82. doi: NULL. [PMID: 16604954]
  • Christina S Barr, Timothy K Newman, Stephen Lindell, Courtney Shannon, Maribeth Champoux, Klaus Peter Lesch, Stephen J Suomi, David Goldman, J Dee Higley. Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Archives of general psychiatry. 2004 Nov; 61(11):1146-52. doi: 10.1001/archpsyc.61.11.1146. [PMID: 15520362]
  • Ludovico Coppola, Antonino Coppola, Antonio Grassia, Luigia Mastrolorenzo, Biagio Lettieri, Domenico De Lucia, Annarita De Nanzio, Giorgio Gombos. Acute hyperglycemia alters von Willebrand factor but not the fibrinolytic system in elderly subjects with normal or impaired glucose tolerance. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2004 Oct; 15(8):629-35. doi: 10.1097/00001721-200412000-00002. [PMID: 15613917]
  • W L Hall, D J Millward, P J Rogers, L M Morgan. Physiological mechanisms mediating aspartame-induced satiety. Physiology & behavior. 2003 Apr; 78(4-5):557-62. doi: 10.1016/s0031-9384(03)00034-9. [PMID: 12782208]
  • Bernard Beck, Arlette Burlet, Jean Pierre Max, Alain Stricker-Krongrad. Effects of long-term ingestion of aspartame on hypothalamic neuropeptide Y, plasma leptin and body weight gain and composition. Physiology & behavior. 2002 Feb; 75(1-2):41-7. doi: 10.1016/s0031-9384(01)00654-0. [PMID: 11890951]
  • L Kovatsi, M Tsouggas. The effect of oral aspartame administration on the balance of magnesium in the rat. Magnesium research. 2001 Sep; 14(3):189-94. doi: NULL. [PMID: 11599551]
  • I Baudrimont, B Sostaric, C Yenot, A M Betbeder, S Dano-Djedje, A Sanni, P S Steyn, E E Creppy. Aspartame prevents the karyomegaly induced by ochratoxin A in rat kidney. Archives of toxicology. 2001 May; 75(3):176-83. doi: 10.1007/s002040100229. [PMID: 11409539]
  • D L Harris, E King, P A Ramsland, A B Edmundson. Binding of nascent collagen by amyloidogenic light chains and amyloid fibrillogenesis in monolayers of human fibrocytes. Journal of molecular recognition : JMR. 2000 Jul; 13(4):198-212. doi: 10.1002/1099-1352(200007/08)13:4<198::aid-jmr499>3.0.co;2-d. [PMID: 10931557]
  • L Prat-Larquemin, J M Oppert, F Bellisle, B Guy-Grand. Sweet taste of aspartame and sucrose: effects on diet-induced thermogenesis. Appetite. 2000 Jun; 34(3):245-51. doi: 10.1006/appe.1999.0310. [PMID: 10888287]
  • P A Ramsland, B F Movafagh, M Reichlin, A B Edmundson. Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester. Journal of molecular recognition : JMR. 1999 Sep; 12(5):249-57. doi: NULL. [PMID: 10777254]
  • G Schwerdt, R Freudinger, S Silbernagl, M Gekle. Ochratoxin A-binding proteins in rat organs and plasma and in different cell lines of the kidney. Toxicology. 1999 Jul; 135(1):1-10. doi: 10.1016/s0300-483x(99)00028-1. [PMID: 10454219]
  • P A Ramsland, B F Movafagh, M Reichlin, A B Edmundson. Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester. Journal of molecular recognition : JMR. 1999 Jul; 12(4):249-57. doi: 10.1002/(sici)1099-1352(199907/08)12:4<249::aid-jmr463>3.0.co;2-b. [PMID: 10440996]
  • M J Singleton, C Heiser, K Jamesen, R D Mattes. Sweetener augmentation of serum triacylglycerol during a fat challenge test in humans. Journal of the American College of Nutrition. 1999 Apr; 18(2):179-85. doi: 10.1080/07315724.1999.10718847. [PMID: 10204835]
  • A S Leon. Comment on effect of large doses of aspartame on urinary calcium excretion. The Journal of clinical endocrinology and metabolism. 1999 Jan; 84(1):383-4. doi: 10.1210/jc.84.1.383-b. [PMID: 9920115]
  • P A Spiers, L Sabounjian, A Reiner, D K Myers, J Wurtman, D L Schomer. Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects. The American journal of clinical nutrition. 1998 Sep; 68(3):531-7. doi: 10.1093/ajcn/68.3.531. [PMID: 9734727]
  • E E Creppy, I Baudrimont, Anne-Marie. How aspartame prevents the toxicity of ochratoxin A. The Journal of toxicological sciences. 1998 Jul; 23 Suppl 2(?):165-72. doi: 10.2131/jts.23.supplementii_165. [PMID: 9760456]
  • C Trocho, R Pardo, I Rafecas, J Virgili, X Remesar, J A Fernández-López, M Alemany. Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life sciences. 1998; 63(5):337-49. doi: 10.1016/s0024-3205(98)00282-3. [PMID: 9714421]
  • U N Nguyen, G Dumoulin, M T Henriet, J Regnard. Aspartame ingestion increases urinary calcium, but not oxalate excretion, in healthy subjects. The Journal of clinical endocrinology and metabolism. 1998 Jan; 83(1):165-8. doi: 10.1210/jcem.83.1.4511. [PMID: 9435435]
  • I Baudrimont, R Ahouandjivo, E E Creppy. Prevention of lipid peroxidation induced by ochratoxin A in Vero cells in culture by several agents. Chemico-biological interactions. 1997 Apr; 104(1):29-40. doi: 10.1016/s0009-2797(97)03764-2. [PMID: 9158693]
  • L C Silva, R F Pires, J C Coelho, L B Jardim, R Giugliani. Evaluation of an aspartame loading test for the detection of heterozygotes for classical phenylketonuria. Clinical genetics. 1997 Apr; 51(4):231-5. doi: 10.1111/j.1399-0004.1997.tb02460.x. [PMID: 9184243]
  • L Abdallah, M Chabert, J Louis-Sylvestre. Cephalic phase responses to sweet taste. The American journal of clinical nutrition. 1997 Mar; 65(3):737-43. doi: 10.1093/ajcn/65.3.737. [PMID: 9062523]
  • I Baudrimont, A M Betbeder, E E Creppy. Reduction of the ochratoxin A-induced cytotoxicity in Vero cells by aspartame. Archives of toxicology. 1997; 71(5):290-8. doi: 10.1007/s002040050389. [PMID: 9137807]
  • S Puthrasingam, W M Heybroek, A Johnston, V Maskrey, C G Swift, P Turner, S M Abrams, S H Jackson. Aspartame pharmacokinetics - the effect of ageing. Age and ageing. 1996 May; 25(3):217-20. doi: 10.1093/ageing/25.3.217. [PMID: 8670556]
  • E E Creppy, I Baudrimont, A Belmadani, A M Betbeder. Aspartame as a preventive agent of chronic toxic effects of ochratoxin A in experimental animals. Food additives and contaminants. 1996; 13 Suppl(?):51-2. doi: NULL. [PMID: 8972353]
  • L D Stegink, S D Lindgren, M C Brummel, P J Stumbo, M L Wolraich. Erythrocyte L-aspartyl-L-phenylalanine hydrolase activity and plasma phenylalanine and aspartate concentrations in children consuming diets high in aspartame. The American journal of clinical nutrition. 1995 Dec; 62(6):1206-11. doi: 10.1093/ajcn/62.6.1206. [PMID: 7491881]
  • E E Creppy, I Baudrimont, A M Betbeder. Prevention of nephrotoxicity of ochratoxin A, a food contaminant. Toxicology letters. 1995 Dec; 82-83(?):869-77. doi: 10.1016/0378-4274(95)03601-6. [PMID: 8597155]
  • K L Teff, J Devine, K Engelman. Sweet taste: effect on cephalic phase insulin release in men. Physiology & behavior. 1995 Jun; 57(6):1089-95. doi: 10.1016/0031-9384(94)00373-d. [PMID: 7652029]
  • A J Rowan, B A Shaywitz, L Tuchman, J A French, D Luciano, C M Sullivan. Aspartame and seizure susceptibility: results of a clinical study in reportedly sensitive individuals. Epilepsia. 1995 Mar; 36(3):270-5. doi: 10.1111/j.1528-1157.1995.tb00995.x. [PMID: 7614911]
  • H C Curtius, W Endres, N Blau. Effect of high-protein meal plus aspartame ingestion on plasma phenylalanine concentrations in obligate heterozygotes for phenylketonuria. Metabolism: clinical and experimental. 1994 Apr; 43(4):413-6. doi: 10.1016/0026-0495(94)90068-x. [PMID: 8159095]
  • F Trefz, L de Sonneville, P Matthis, C Benninger, B Lanz-Englert, H Bickel. Neuropsychological and biochemical investigations in heterozygotes for phenylketonuria during ingestion of high dose aspartame (a sweetener containing phenylalanine). Human genetics. 1994 Apr; 93(4):369-74. doi: 10.1007/bf00201660. [PMID: 8168806]
  • N M Hooper, R J Hesp, S Tieku. Metabolism of aspartame by human and pig intestinal microvillar peptidases. The Biochemical journal. 1994 Mar; 298 Pt 3(?):635-9. doi: 10.1042/bj2980635. [PMID: 8141778]
  • B A Shaywitz, C M Sullivan, G M Anderson, S M Gillespie, B Sullivan, S E Shaywitz. Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics. 1994 Jan; 93(1):70-5. doi: NULL. [PMID: 7505423]
  • B A Shaywitz, G M Anderson, E J Novotny, J S Ebersole, C M Sullivan, S M Gillespie. Aspartame has no effect on seizures or epileptiform discharges in epileptic children. Annals of neurology. 1994 Jan; 35(1):98-103. doi: 10.1002/ana.410350115. [PMID: 7506878]
  • B E Reed, A P Barrett, C Katelaris, M Bilous. Orofacial sensitivity reactions and the role of dietary components. Case reports. Australian dental journal. 1993 Aug; 38(4):287-91. doi: 10.1111/j.1834-7819.1993.tb05499.x. [PMID: 8216037]
  • Z I Hertelendy, C L Mendenhall, S D Rouster, L Marshall, R Weesner. Biochemical and clinical effects of aspartame in patients with chronic, stable alcoholic liver disease. The American journal of gastroenterology. 1993 May; 88(5):737-43. doi: NULL. [PMID: 8480740]
  • P J Karstaedt, J H Pincus. Aspartame use in Parkinson's disease. Neurology. 1993 Mar; 43(3 Pt 1):611-3. doi: 10.1212/wnl.43.3_part_1.611. [PMID: 8451009]
  • S A Mackey, C M Berlin. Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients. Clinical pediatrics. 1992 Jul; 31(7):394-9. doi: 10.1177/000992289203100703. [PMID: 1617863]
  • J J Hjelle, R E Dudley, M P Marietta, P G Sanders, B C Dickie, J Brisson, F N Kotsonis. Plasma concentrations and pharmacokinetics of phenylalanine in rats and mice administered aspartame. Pharmacology. 1992; 44(1):48-60. doi: 10.1159/000138873. [PMID: 1553388]
  • G Guiso, L Diomede, M Romano, S Caccia, S Sarati, M Salmona. Effect of tyrosine on the potentiation by aspartame and phenylalanine of metrazol-induced convulsions in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1991 Dec; 29(12):855-7. doi: 10.1016/0278-6915(91)90114-m. [PMID: 1765332]
  • J C Melchior, D Rigaud, N Colas-Linhart, A Petiet, A Girard, M Apfelbaum. Immunoreactive beta-endorphin increases after an aspartame chocolate drink in healthy human subjects. Physiology & behavior. 1991 Nov; 50(5):941-4. doi: 10.1016/0031-9384(91)90418-n. [PMID: 1805284]
  • J D Higley, M F Hasert, S J Suomi, M Linnoila. Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption. Proceedings of the National Academy of Sciences of the United States of America. 1991 Aug; 88(16):7261-5. doi: 10.1073/pnas.88.16.7261. [PMID: 1871131]
  • S E Møller. Effect of aspartame and protein, administered in phenylalanine-equivalent doses, on plasma neutral amino acids, aspartate, insulin and glucose in man. Pharmacology & toxicology. 1991 May; 68(5):408-12. doi: 10.1111/j.1600-0773.1991.tb01262.x. [PMID: 1946186]
  • R A Koeppe, B L Shulkin, K C Rosenspire, L A Shaw, A L Betz, T Mangner, J C Price, B W Agranoff. Effect of aspartame-derived phenylalanine on neutral amino acid uptake in human brain: a positron emission tomography study. Journal of neurochemistry. 1991 May; 56(5):1526-35. doi: 10.1111/j.1471-4159.1991.tb02047.x. [PMID: 2013754]