2-(4-Chlorophenoxy)propionic acid (BioDeep_00000009516)
Secondary id: BioDeep_00001875876
human metabolite blood metabolite
代谢物信息卡片
化学式: C9H9ClO3 (200.024)
中文名称: 2-(4-氯苯氧基)丙酸
谱图信息:
最多检出来源 Homo sapiens(blood) 70%
分子结构信息
SMILES: CC(C(=O)O)OC1=CC=C(C=C1)Cl
InChI: InChI=1S/C9H9ClO3/c1-6(9(11)12)13-8-4-2-7(10)3-5-8/h2-6H,1H3,(H,11,12)
描述信息
同义名列表
15 个代谢物同义名
2-(4-Chlorophenoxy)propionic acid, potassium salt; 2-(4-Chlorophenoxy)propionic acid, (+-)-isomer; 2-(4-Chlorophenoxy)propionic acid, (S)-isomer; 2-(4-Chlorophenoxy)propionic acid, (R)-isomer; 2-(4-Chlorophenoxy)propionic acid; 2-(p-Chlorophenoxy)propionic acid; 2-(4-CHLOROPHENOXY)PROPANOIC ACID; 2-(p-Chlorophenoxy)propionate; 2-(4-Chlorophenoxy)propanoate; 2-(4-Chlorophenoxy)propionate; C9H9ClO3; 2-p-CPP; 4-CPP; CPP; 2-(4-Chlorophenoxy)propionic acid
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34603
- KEGG: C13701
- PubChem: 18703
- HMDB: HMDB0244931
- Metlin: METLIN69646
- ChEMBL: CHEMBL23629
- chemspider: 17662
- CAS: 3307-39-9
- PMhub: MS000023308
- PubChem: 586290
- NIKKAJI: J7.716J
- KNApSAcK: 34603
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Darren M Roberts, Andrew H Dawson, Lalith Senarathna, Fahim Mohamed, Ron Cheng, Geoffrey Eaglesham, Nick A Buckley. Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning.
Toxicology letters.
2011 Mar; 201(3):270-6. doi:
10.1016/j.toxlet.2011.01.011
. [PMID: 21256202] - Antonella Gradogna, Michael Pusch. Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels.
Frontiers in pharmacology.
2010; 1(?):130. doi:
10.3389/fphar.2010.00130
. [PMID: 21833170] - Christoph Fahlke, Martin Fischer. Physiology and pathophysiology of ClC-K/barttin channels.
Frontiers in physiology.
2010; 1(?):155. doi:
10.3389/fphys.2010.00155
. [PMID: 21423394] - Yukari Egashira, Makiko Sato, Mayuki Sato, Ryoko Sugawara, Atsushi Tanabe, Mariko Shin, Hiroo Sanada. Differential effects of pyrazinamide and clofibrate on gene expression of rat hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme of the tryptophan-NAD pathway.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2006 May; 76(3):138-46. doi:
10.1024/0300-9831.76.3.138
. [PMID: 17048193] - Antonella Liantonio, Alessandra Picollo, Elena Babini, Giuseppe Carbonara, Giuseppe Fracchiolla, Fulvio Loiodice, Vincenzo Tortorella, Michael Pusch, Diana Conte Camerino. Activation and inhibition of kidney CLC-K chloride channels by fenamates.
Molecular pharmacology.
2006 Jan; 69(1):165-73. doi:
10.1124/mol.105.017384
. [PMID: 16244177] - M Pusch, G Zifarelli, A R Murgia, A Picollo, E Babini. Channel or transporter? The CLC saga continues.
Experimental physiology.
2006 Jan; 91(1):149-52. doi:
10.1113/expphysiol.2005.031799
. [PMID: 16179405] - Tye E Arbuckle, Len Ritter. Phenoxyacetic acid herbicide exposure for women on Ontario farms.
Journal of toxicology and environmental health. Part A.
2005 Aug; 68(15):1359-70. doi:
10.1080/15287390590953635
. [PMID: 16020195] - Alessandra Picollo, Antonella Liantonio, Maria Paola Didonna, Laura Elia, Diana Conte Camerino, Michael Pusch. Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.
EMBO reports.
2004 Jun; 5(6):584-9. doi:
10.1038/sj.embor.7400169
. [PMID: 15167890] - Antonella Liantonio, Michael Pusch, Alessandra Picollo, Patrizia Guida, Annamaria De Luca, Sabata Pierno, Giuseppe Fracchiolla, Fulvio Loiodice, Paolo Tortorella, Diana Conte Camerino. Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers.
Journal of the American Society of Nephrology : JASN.
2004 Jan; 15(1):13-20. doi:
10.1097/01.asn.0000103226.28798.ea
. [PMID: 14694153] - Antonella Liantonio, Alessio Accardi, Giuseppe Carbonara, Giuseppe Fracchiolla, Fulvio Loiodice, Paolo Tortorella, Sonia Traverso, Patrizia Guida, Sabata Pierno, Annamaria De Luca, Diana Conte Camerino, Michael Pusch. Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.
Molecular pharmacology.
2002 Aug; 62(2):265-71. doi:
10.1124/mol.62.2.265
. [PMID: 12130677] - A De Luca, S Pierno, C Camerino, D Cocchi, D C Camerino. Higher content of insulin-like growth factor-I in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function.
Neuromuscular disorders : NMD.
1999 Jan; 9(1):11-8. doi:
10.1016/s0960-8966(98)00092-3
. [PMID: 10063830] - T A Esbenshade, V S Kamanna, H A Newman, V Tortorella, D T Witiak, D R Feller. In vivo and in vitro peroxisome proliferation properties of selected clofibrate analogues in the rat. Structure-activity relationships.
Biochemical pharmacology.
1990 Sep; 40(6):1263-74. doi:
10.1016/0006-2952(90)90392-x
. [PMID: 2403380] - D R Feller, V S Kamanna, H A Newman, K J Romstedt, D T Witiak, G Bettoni, S H Bryant, D Conte-Camerino, F Loiodice, V Tortorella. Dissociation of hypolipidemic and antiplatelet actions from adverse myotonic effects of clofibric acid related enantiomers.
Journal of medicinal chemistry.
1987 Aug; 30(8):1265-7. doi:
10.1021/jm00391a001
. [PMID: 2441050]