Gene Association: SETD3

UniProt Search: SETD3 (PROTEIN_CODING)
Function Description: SET domain containing 3, actin N3(tau)-histidine methyltransferase

found 6 associated metabolites with current gene based on the text mining result from the pubmed database.

Dimethylglycine

N-Methylsarcosine N,N-dimethyl-glycine

C4H9NO2 (103.0633)


Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. The human body produces DMG when metabolizing choline into glycine. Dimethylglycine that is not metabolized in the liver is transported by the circulatory system to body tissue. Dimethylglycine was popular with Russian athletes and cosmonauts owing to its reputed ability to increase endurance and reduce fatigue. DMG is also a byproduct of homocysteine metabolism. Homocysteine and betaine are converted to methionine and N,N-dimethylglycine by betaine-homocysteine methyltransferase. DMG in the urine is a biomarker for the consumption of legumes. It is also a microbial metabolite (PMID: 25901889). Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. The human body produces DMG when metabolizing choline into Glycine. Dimethylglycine that is not metabolized in the liver is transported by the circulatory system to body tissue. Dimethylglycine was popular with Russian athletes and cosmonauts owing to its reputed ability to increase endurance and reduce fatigue. DMG is also a byproduct of homocysteine metabolism. Homocysteine and betaine are converted to methionine and N, N-dimethylglycine by betaine-homocysteine methyltransferase. [HMDB]. Dimethylglycine in the urine is a biomarker for the consumption of legumes. N,N-Dimethylglycine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=1118-68-9 (retrieved 2024-07-16) (CAS RN: 1118-68-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0). N-Methylsarcosine is an amino acid building block for protein, found in a small amount in the body.

   

Nalpha-Methylhistidine

Nalpha-Methylhistidine

C7H11N3O2 (169.0851)


   

Trimethyl sulfonium

Trimethylsulphonium chloride

[C3H9S]+ (77.0425)


Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses [HMDB] Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses. KEIO_ID T058

   

N,N-dimethylglycine

N,N-Dimethylglycine hydrochloride

C4H9NO2 (103.0633)


An N-methylglycine that is glycine carrying two N-methyl substituents. N-Methylsarcosine is an amino acid building block for protein, found in a small amount in the body.

   

Trimethylsulfonium

Trimethylsulfonium

C3H9S+ (77.0425)


A sulfonium compound in which the substituents on sulfur are three methyl groups. It is found in the midgut gland of the sea hare, Aplysia brasiliana, and exhibits probable ability to inhibit cholinergic responses.

   

N-Methyl-L-histidine

N-Methyl-L-histidine

C7H11N3O2 (169.0851)