Talactoferrin Alfa (BioDeep_00000008878)

 

Secondary id: BioDeep_00001883409

human metabolite blood metabolite


代谢物信息卡片


3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide monomethanesulfonate, (trans)-(+-)-isomer

化学式: C19H26Cl2N2O (368.1422)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 79.41%

分子结构信息

SMILES: CN(C(=O)Cc1ccc(Cl)c(Cl)c1)C1CCCCC1N1CCCC1
InChI: InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3

描述信息

D000970 - Antineoplastic Agents

同义名列表

19 个代谢物同义名

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide monomethanesulfonate, (trans)-(+-)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide monomethanesulfonate, (trans)-(+)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide monomethanesulfonate, (trans)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide mesylate, (trans)-(+-)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide mesylate, (trans)-(+)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (trans)-(+-)-isomer; trans-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide hydrochloride; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (trans)-(-)-isomer; Benzeneacetamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, (trans)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (1S-cis)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (1R-cis)-isomer; trans-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide; trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide; 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(pyrrolidin-1-yl)cyclohexyl]acetamide; 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]acetamide; Talactoferrin Alfa; U50488; U50488



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tânia C Chicre-Alcântara, Karla E Torres-Chávez, Luana Fischer, Juliana T Clemente-Napimoga, Vilma Melo, Carlos Amílcar Parada, Claudia Herrera Tambeli. Local kappa opioid receptor activation decreases temporomandibular joint inflammation. Inflammation. 2012 Feb; 35(1):371-6. doi: 10.1007/s10753-011-9329-1. [PMID: 21484425]
  • Xiaodong Wu, Bo Zhang, Rong Fan, Lei Zhao, Yuemin Wang, Shumiao Zhang, Alan David Kaye, Luyu Huang, Jianming Pei. U50,488H inhibits neutrophil accumulation and TNF-α induction induced by ischemia-reperfusion in rat heart. Cytokine. 2011 Nov; 56(2):503-7. doi: 10.1016/j.cyto.2011.07.015. [PMID: 21843951]
  • B A S Reyes, Charles Chavkin, E J Van Bockstaele. Agonist-induced internalization of κ-opioid receptors in noradrenergic neurons of the rat locus coeruleus. Journal of chemical neuroanatomy. 2010 Dec; 40(4):301-9. doi: 10.1016/j.jchemneu.2010.09.003. [PMID: 20884346]
  • Amardeep Jaiswal, Santosh Kumar, Sandeep Seth, Amit Kumar Dinda, Subir Kumar Maulik. Effect of U50,488H, a κ-opioid receptor agonist on myocardial α-and β-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced cardiac hypertrophy in rat. Molecular and cellular biochemistry. 2010 Dec; 345(1-2):231-40. doi: 10.1007/s11010-010-0577-4. [PMID: 20730476]
  • Teresa G Hayes, Gerald S Falchook, Atul Varadhachary. Phase IB trial of oral talactoferrin in the treatment of patients with metastatic solid tumors. Investigational new drugs. 2010 Apr; 28(2):156-62. doi: 10.1007/s10637-009-9233-9. [PMID: 19238327]
  • Aashish S Morani, Bronwyn Kivell, Thomas E Prisinzano, Susan Schenk. Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. Pharmacology, biochemistry, and behavior. 2009 Dec; 94(2):244-9. doi: 10.1016/j.pbb.2009.09.002. [PMID: 19747933]
  • Yulin Wang, Wei Xu, Peng Huang, Charles Chavkin, Elisabeth J Van Bockstaele, Lee-Yuan Liu-Chen. Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord. Journal of neuroscience research. 2009 May; 87(7):1695-702. doi: 10.1002/jnr.21971. [PMID: 19130621]
  • Fan Rong, Zhang Peng, Ming-Xiang Ye, Quan-Yu Zhang, Yin Zhao, Shu-Miao Zhang, Hai-Tao Guo, Bi Hui, Yue-Min Wang, Cheng Liang, Chun-Hu Gu, Chen Tao, Qin Cui, Shi-Qiang Yu, Ding-Hua Yi, Jian-Ming Pei. Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist. Archives of medical research. 2009 May; 40(4):227-34. doi: 10.1016/j.arcmed.2009.04.009. [PMID: 19608010]
  • Lisa E Baker, John J Panos, Bryan A Killinger, Mary M Peet, Lisa M Bell, Larissa A Haliw, Sheryl L Walker. Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats. Psychopharmacology. 2009 Apr; 203(2):203-11. doi: 10.1007/s00213-008-1458-3. [PMID: 19153716]
  • Craig Bolte, Gilbert Newman, Jo El J Schultz. Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation. American journal of physiology. Heart and circulatory physiology. 2009 Apr; 296(4):H967-75. doi: 10.1152/ajpheart.00909.2008. [PMID: 19181965]
  • Walter Wittmann, Eduard Schunk, Iris Rosskothen, Stefano Gaburro, Nicolas Singewald, Herbert Herzog, Christoph Schwarzer. Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 Feb; 34(3):775-85. doi: 10.1038/npp.2008.142. [PMID: 18800067]
  • Eric Jonasch, Walter M Stadler, Ronald M Bukowski, Teresa G Hayes, Atul Varadhachary, Rajesh Malik, Robert A Figlin, Sandy Srinivas. Phase 2 trial of talactoferrin in previously treated patients with metastatic renal cell carcinoma. Cancer. 2008 Jul; 113(1):72-7. doi: 10.1002/cncr.23519. [PMID: 18484647]
  • John E Pascoe, Keith L Williams, Partha Mukhopadhyay, Kenner C Rice, James H Woods, Mei-Chuan Ko. Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys. Psychoneuroendocrinology. 2008 May; 33(4):478-86. doi: 10.1016/j.psyneuen.2008.01.006. [PMID: 18325678]
  • R Capasso, F Borrelli, J Zjawiony, L Kutrzeba, G Aviello, G Sarnelli, F Capasso, A A Izzo. The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2008 Feb; 20(2):142-8. doi: 10.1111/j.1365-2982.2007.00994.x. [PMID: 17931335]
  • Hai-Tao Guo, Rong-Huai Zhang, Lu-Yu Huang, Juan Li, Ya-Li Liu, Hui Bi, Quan Yu Zhang, Yue-Min Wang, Xin Sun, Xin-Liang Ma, Liang Cheng, Jing-Cheng Liu, Shi-Qiang Yu, Ding-Hua Yi, Jian-Ming Pei. Mechanisms involved in the hypotensive effect of a kappa-opioid receptor agonist in hypertensive rats. Archives of medical research. 2007 Oct; 38(7):723-9. doi: 10.1016/j.arcmed.2007.04.009. [PMID: 17845890]
  • Mohan Pammi Venkatesh, Don Pham, Lingkun Kong, Leonard E Weisman. Prophylaxis with lactoferrin, a novel antimicrobial agent, in a neonatal rat model of coinfection. Advances in therapy. 2007 Sep; 24(5):941-54. doi: 10.1007/bf02877698. [PMID: 18029319]
  • Liang Cheng, Sai Ma, Long-Xiao Wei, Hai-Tao Guo, Lu-Yu Huang, Hui Bi, Rong Fan, Juan Li, Ya-Li Liu, Yue-Min Wang, Xin Sun, Quan-Yu Zhang, Shi-Qiang Yu, Ding-Hua Yi, Xin-Liang Ma, Jian-Ming Pei. Cardioprotective and antiarrhythmic effect of U50,488H in ischemia/reperfusion rat heart. Heart and vessels. 2007 Sep; 22(5):335-44. doi: 10.1007/s00380-007-0983-z. [PMID: 17879026]
  • Wei Qi, K Kumar Ebenezar, Mohamed A Samhan, Francine G Smith. Renal responses to the kappa-opioid-receptor agonist U-50488H in conscious lambs. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Jul; 293(1):R162-8. doi: 10.1152/ajpregu.00863.2006. [PMID: 17409260]
  • Wei Qi, Francine G Smith. Modulation of systemic and renal haemodynamics by kappa-opioids in conscious lambs. Experimental physiology. 2006 Sep; 91(5):877-85. doi: 10.1113/expphysiol.2006.033456. [PMID: 16728455]
  • Jay P McLaughlin, Benjamin B Land, Shuang Li, John E Pintar, Charles Chavkin. Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Apr; 31(4):787-94. doi: 10.1038/sj.npp.1300860. [PMID: 16123754]
  • Chongguang Chen, Jian-Guo Li, Yong Chen, Peng Huang, Yulin Wang, Lee-Yuan Liu-Chen. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. The Journal of biological chemistry. 2006 Mar; 281(12):7983-93. doi: 10.1074/jbc.m509805200. [PMID: 16431922]
  • Eva Maria Marco, Ricardo Llorente, Laura Pérez-Alvarez, Enrique Moreno, Carmen Guaza, Maria Paz Viveros. The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety. Behavioural brain research. 2005 Sep; 163(2):212-8. doi: 10.1016/j.bbr.2005.05.005. [PMID: 15979169]
  • Eddy H T Wu, Yung H Wong. Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells. Biochemical and biophysical research communications. 2005 Sep; 334(3):838-44. doi: 10.1016/j.bbrc.2005.06.184. [PMID: 16053916]
  • Asunción Romero, Eulalia Planas, Raquel Poveda, Silvia Sánchez, Olga Pol, Margarita M Puig. Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw. European journal of pharmacology. 2005 Mar; 511(2-3):207-17. doi: 10.1016/j.ejphar.2005.02.004. [PMID: 15792790]
  • Shiou-Lan Chen, Eagle Yi-Kung Huang, Lok-Hi Chow, Pao-Luh Tao. Dextromethorphan differentially affects opioid antinociception in rats. British journal of pharmacology. 2005 Feb; 144(3):400-4. doi: 10.1038/sj.bjp.0706086. [PMID: 15655510]
  • Helmut B Gottlieb, Kurt J Varner, Velga A Kenigs, Antonio M Cabral, Daniel R Kapusta. Differential cardiovascular and renal responses produced by microinjection of the {kappa}-opioid U-50488H [(trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzene-acetamide) methane sulfonate] into subregions of the paraventricular nucleus. The Journal of pharmacology and experimental therapeutics. 2005 Feb; 312(2):678-85. doi: 10.1124/jpet.104.076828. [PMID: 15381735]
  • Juliana T Clemente, Carlos A Parada, Maria C Arruda Veiga, Robert W Gear, Cláudia H Tambeli. Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint. Neuroscience letters. 2004 Dec; 372(3):250-5. doi: 10.1016/j.neulet.2004.09.048. [PMID: 15542250]
  • Guijun Wang, Hongxin Wang, Yanling Yang, Tak Ming Wong. Kappa-opioid receptor stimulation inhibits growth of neonatal rat ventricular myocytes. European journal of pharmacology. 2004 Sep; 498(1-3):53-8. doi: 10.1016/j.ejphar.2004.07.082. [PMID: 15363975]
  • Magdalena Chadzinska, Barbara Plytycz. Differential migratory properties of mouse, fish, and frog leukocytes treated with agonists of opioid receptors. Developmental and comparative immunology. 2004 Jul; 28(9):949-58. doi: 10.1016/j.dci.2004.02.003. [PMID: 15183035]
  • Peng Huang, Deborah Steplock, Edward J Weinman, Randy A Hall, Zhe Ding, Jianguo Li, Yulin Wang, Lee-Yuan Liu-Chen. kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. The Journal of biological chemistry. 2004 Jun; 279(24):25002-9. doi: 10.1074/jbc.m313366200. [PMID: 15070904]
  • M Soaje, R P Deis. Involvement of opioid receptor subtypes in both stimulatory and inhibitory effects of the opioid peptides on prolactin secretion during pregnancy. Cellular and molecular neurobiology. 2004 Apr; 24(2):193-204. doi: 10.1023/b:cemn.0000018616.00018.98. [PMID: 15176435]
  • Selim Kutlu, Bayram Yilmaz, Sinan Canpolat, Suleyman Sandal, Mete Ozcan, Selahattin Kumru, Haluk Kelestimur. Mu opioid modulation of oxytocin secretion in late pregnant and parturient rats. Involvement of noradrenergic neurotransmission. Neuroendocrinology. 2004; 79(4):197-203. doi: 10.1159/000078101. [PMID: 15153753]
  • M C H Ko, K J Willmont, H Lee, G S Flory, J H Woods. Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys. Brain research. 2003 Aug; 982(1):38-44. doi: 10.1016/s0006-8993(03)02938-x. [PMID: 12915238]
  • R Wood, L Eichel, E M Messing, E Schwarz. Automated noninvasive measurement of cyclophosphamide-induced changes in murine micturition frequency and volume and demonstration of pharmacologic sensitivity. Urology. 2001 Jun; 57(6 Suppl 1):115-6. doi: 10.1016/s0090-4295(01)01059-7. [PMID: 11378091]
  • D C Brown, S Z Perkowski, F Shofer, J A Amico. Effect of centrally administered opioid receptor agonists on CSF and plasma oxytocin concentrations in dogs. American journal of veterinary research. 2001 Apr; 62(4):496-9. doi: 10.2460/ajvr.2001.62.496. [PMID: 11327454]
  • S Kumru, M Simşek, B Yilmaz, E Sapmaz, S Kutlu, S Sandal, S Canpolat. Differential regulation of preovulatory luteinizing hormone and follicle-stimulating hormone release by opioids in the proestrous rat. Physiological research. 2001; 50(4):397-403. doi: NULL. [PMID: 11551146]
  • D A Bereiter. Sex differences in brainstem neural activation after injury to the TMJ region. Cells, tissues, organs. 2001; 169(3):226-37. doi: 10.1159/000047886. [PMID: 11455118]
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