S-Hydroxymethylglutathione (BioDeep_00000009741)

 

Secondary id: BioDeep_00001871581

human metabolite Endogenous


代谢物信息卡片


(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(hydroxymethyl)sulfanyl]ethyl]carbamoyl}butanoic acid

化学式: C11H19N3O7S (337.0944)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 24.1%

分子结构信息

SMILES: C(CC(=O)NC(CSCO)C(=O)NCC(=O)O)C(C(=O)O)N
InChI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

描述信息

S-Hydroxymethylglutathione is a critical component of the binding site for activating fatty acids in glutathione-dependent formaldehyde dehydrogenase activity (OMIM: 103710). Formaldehyde dehydrogenase (FDH; EC 1.2.1.1), a widely occurring enzyme, catalyzes the oxidation of S-hydroxymethylglutathione into S-formylglutathione in the presence of NAD (PMID: 2806555).
S-Hydroxymethylglutathione is a critical component of the binding site for activating fatty acids in glutathione-dependent formaldehyde dehydrogenase activity. (OMIM 103710)

同义名列表

15 个代谢物同义名

(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(hydroxymethyl)sulfanyl]ethyl]carbamoyl}butanoic acid; 2-amino-4-[1-CARBOXYMETHYL-carbamoyl)-2-hydroxymethylsulphanyl-ethylcarbamoyl]-butyric acid; 2-amino-4-[1-CARBOXYMETHYL-carbamoyl)-2-hydroxymethylsulfanyl-ethylcarbamoyl]-butyrIC ACID; 2-amino-4-[1-CARBOXYMETHYL-carbamoyl)-2-hydroxymethylsulphanyl-ethylcarbamoyl]-butyrate; 2-amino-4-[1-CARBOXYMETHYL-carbamoyl)-2-hydroxymethylsulfanyl-ethylcarbamoyl]-butyrate; L-gamma-Glutamyl-S-(hydroxymethyl)-L-cysteinylglycine; L-γ-Glutamyl-S-(hydroxymethyl)-L-cysteinylglycine; Glutathione-formaldehyde thiohemiacetal; Formaldehyde-glutathione thiohemiacetal; S-(Hydroxymethyl)glutathione; S-Hydroxymethyl-glutathione; S-Hydroxymethylglutathione; LJP 1082; SerGSH; S-(Hydroxymethyl)glutathione



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

69 个相关的代谢反应过程信息。

Reactome(68)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • I V Seregin, R Vooijs, A D Kozhevnikova, V B Ivanov, H Schat. Effects of cadmium and lead on phytochelatin accumulation in maize shoots and different root parts. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 2007 Jul; 415(?):304-6. doi: 10.1134/s0012496607040163. [PMID: 17929673]
  • Mark J Reimers, Mark E Hahn, Robert L Tanguay. Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics. The Journal of biological chemistry. 2004 Sep; 279(37):38303-12. doi: 10.1074/jbc.m401165200. [PMID: 15231826]
  • Gábor Kocsy, Gabriella Szalai, Gábor Galiba. Effect of osmotic stress on glutathione and hydroxymethylglutathione accumulation in wheat. Journal of plant physiology. 2004 Jul; 161(7):785-94. doi: 10.1016/j.jplph.2003.12.006. [PMID: 15310067]
  • Gábor Kocsy, Gabriella Szalai, Gábor Galiba. Induction of glutathione synthesis and glutathione reductase activity by abiotic stresses in maize and wheat. TheScientificWorldJournal. 2002 Jun; 2(?):1699-705. doi: 10.1100/tsw.2002.812. [PMID: 12806164]
  • G Kocsy, G Szalai, A Vágújfalvi, L Stéhli, G Orosz, G Galiba. Genetic study of glutathione accumulation during cold hardening in wheat. Planta. 2000 Jan; 210(2):295-301. doi: 10.1007/pl00008137. [PMID: 10664136]
  • H A Teloh. Serum proteins in hepatic disease. Annals of clinical and laboratory science. 1978 Mar; 8(2):127-9. doi: NULL. [PMID: 637517]
  • C Werner, E Ramirez, C Gervasoni, M Jeannet. Mitigation of graft-versus-host disease in rats treated with allogeneic and xenogeneic antilymphocytic sera. Experientia. 1976 Feb; 32(2):241-2. doi: 10.1007/bf01937788. [PMID: 5281]
  • . . . . doi: . [PMID: 1731906]