Fenspiride (BioDeep_00000179023)

   

human metabolite blood metabolite


代谢物信息卡片


8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]dec-2-en-2-ol

化学式: C15H20N2O2 (260.15247)
中文名称: 盐酸芬斯必利-d5
谱图信息: 最多检出来源 Homo sapiens(blood) 99.5%

分子结构信息

SMILES: C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3
InChI: InChI=1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18)

描述信息

D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
R - Respiratory system > R03 - Drugs for obstructive airway diseases

同义名列表

7 个代谢物同义名

8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]dec-2-en-2-ol; fenspiride hydrochloride; Decaspiride; fenspiride; Pneumorel; Eurespal; Espiran



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Agnieszka Matuszewska, Beata Nowak, Diana Jędrzejuk, Marcin Landwójtowicz, Marek Bolanowski, Wojciech Dziewiszek, Anna Merwid-Ląd, Ewa Szeląg, Krzysztof Zduniak, Joanna Kwiatkowska, Adam Szeląg. Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2019 Jun; 28(6):771-776. doi: 10.17219/acem/93729. [PMID: 30843675]
  • R A Kalekin, A M Orlova, S A Savchuk, S S Barsegyan. [The study of fenspiride: goals and objectives for chemical and toxicological studies]. Sudebno-meditsinskaia ekspertiza. 2019; 62(4):37-41. doi: 10.17116/sudmed20196204137. [PMID: 31407704]
  • Vyacheslav N Zhdan, Maksim М Potyazhenko, Galina S Khaymenova, Nadezhda N Lyulka, Tatyana V Dubrovinskaya, Igor V Ivanitsky. Intensifying approach to the therapy of patients with constellation of the diseases: chronic obstructive pulmonary disease and osteoarthritis. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2017 ; 70(3 pt 2):578-580. doi: . [PMID: 28713086]
  • Andrei Medvedovici, Stefan Udrescu, Florin Albu, Florentin Tache, Victor David. Large-volume injection of sample diluents not miscible with the mobile phase as an alternative approach in sample preparation for bioanalysis: an application for fenspiride bioequivalence. Bioanalysis. 2011 Sep; 3(17):1935-47. doi: 10.4155/bio.11.148. [PMID: 21899503]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • E K Dotsenko, V A Goncharova, N A Kuzubova, M Iu Kamenova, N V Egorova. [The role of expired air moisture condensate in assessment of pulmonary inflammation in patients with chronic obstructive pulmonary disease]. Terapevticheskii arkhiv. 2008; 80(3):10-4. doi: . [PMID: 18441676]
  • T A Fedorova, N V Ekkert, N E Chernekhovskaia, A P Roĭtman, O V Makarova, N V Zhidkova. [Potential of antiinflammatory therapy in patients with chronic obstructive lung disease]. Klinicheskaia meditsina. 2005; 83(7):24-9. doi: . [PMID: 16117420]
  • M C Dumasia, E Houghton, W Hyde, D Greulich, T Nelson, Jackie Peterson. Detection of fenspiride and identification of in vivo metabolites in horse body fluids by capillary gas chromatography-mass spectrometry: administration, biotransformation and urinary excretion after a single oral dose. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Feb; 767(1):131-44. doi: 10.1016/s0378-4347(01)00556-4. [PMID: 11863284]
  • T D Shorokhova, I V Medvedeva, S V Lapik, O G Solov'eva, E Iu Gracheva, R S Iusupova. [Effectiveness of fenspiride in patients with chronic obstructive bronchitis]. Klinicheskaia meditsina. 2001; 79(8):55-7. doi: . [PMID: 11588789]
  • C M De Castro, M A Nahori, C H Dumarey, B B Vargaftig, M Bachelet. Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia. European journal of pharmacology. 1995 Dec; 294(2-3):669-76. doi: 10.1016/0014-2999(95)00608-7. [PMID: 8750732]