6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole (BioDeep_00000008745)

 

Secondary id: BioDeep_00001876993

human metabolite blood metabolite


代谢物信息卡片


5,7-dimethyl-2-(methylamino)-4-[(pyridin-3-yl)methyl]-1,3-benzothiazol-6-ol

化学式: C16H17N3OS (299.1092272)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 95.45%

分子结构信息

SMILES: CC1=C(C2=C(C(=C1O)C)SC(=N2)NC)CC3=CN=CC=C3
InChI: InChI=1S/C16H17N3OS/c1-9-12(7-11-5-4-6-18-8-11)13-15(10(2)14(9)20)21-16(17-3)19-13/h4-6,8,20H,7H2,1-3H3,(H,17,19)

描述信息

同义名列表

7 个代谢物同义名

5,7-dimethyl-2-(methylamino)-4-[(pyridin-3-yl)methyl]-1,3-benzothiazol-6-ol; 5,7-dimethyl-2-(methylamino)-4-(pyridin-3-ylmethyl)-1,3-benzothiazol-6-ol; 6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole; 6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole; E3040 sulfate; e-3040; E3040



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ho Jung Shin, Michio Takeda, Atsushi Enomoto, Masaaki Fujimura, Hiroki Miyazaki, Naohiko Anzai, Hitoshi Endou. Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. Nephrology (Carlton, Vic.). 2011 Feb; 16(2):156-62. doi: 10.1111/j.1440-1797.2010.01368.x. [PMID: 21272127]
  • Masakazu Hirouchi, Hiroyuki Kusuhara, Reiko Onuki, Brian W Ogilvie, Andrew Parkinson, Yuichi Sugiyama. Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4. Drug metabolism and disposition: the biological fate of chemicals. 2009 Oct; 37(10):2103-11. doi: 10.1124/dmd.109.027193. [PMID: 19628752]
  • Naomi Mizuno, Michiko Suzuki, Hiroyuki Kusuhara, Hiroshi Suzuki, Kenji Takeuchi, Takuro Niwa, Johan W Jonker, Yuichi Sugiyama. Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice. Drug metabolism and disposition: the biological fate of chemicals. 2004 Sep; 32(9):898-901. doi: . [PMID: 15319327]
  • H Yamada, H Kotaki, T Itoh, Y Sawada, T Iga. Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles. European journal of pharmacology. 2000 Oct; 406(1):45-8. doi: 10.1016/s0014-2999(00)00626-9. [PMID: 11011031]
  • H Yamada, H Kotaki, H Furitsu, Y Sawada, T Iga. Mechanism of the uricosuric action of E3040, a drug used to treat inflammatory bowel disease II: study using DBA/2N mice. Biopharmaceutics & drug disposition. 1999 Jul; 20(5):271-6. doi: 10.1002/(sici)1099-081x(199907)20:5<271::aid-bdd185>3.0.co;2-i. [PMID: 10594872]
  • H Yamada, H Kotaki, H Furitsu, Y Sawada, T Iga. Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease I: study using a rat model of hyperuricemia. Biopharmaceutics & drug disposition. 1999 Mar; 20(2):77-83. doi: 10.1002/(sici)1099-081x(199903)20:2<77::aid-bdd154>3.0.co;2-d. [PMID: 10206322]
  • O Takenaka, T Horie, H Suzuki, Y Sugiyama. Carrier-mediated active transport of the glucuronide and sulfate of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) into rat liver: quantitative comparison of permeability in isolated hepatocytes, perfused liver and liver in vivo. The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):948-58. doi: . [PMID: 9023311]
  • O Takenaka, T Horie, K Kobayashi, H Suzuki, Y Sugiyama. Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia. Pharmaceutical research. 1995 Nov; 12(11):1746-55. doi: 10.1023/a:1016278008658. [PMID: 8592681]
  • O Takenaka, T Horie, H Suzuki, Y Sugiyama. Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats. The Journal of pharmacology and experimental therapeutics. 1995 Sep; 274(3):1362-9. doi: . [PMID: 7562509]