(S)-Hydroxydecanoyl-CoA (BioDeep_00000005762)
Secondary id: BioDeep_00000228736, BioDeep_00001869350
human metabolite Endogenous
代谢物信息卡片
化学式: C31H54N7O18P3S (937.2458774)
中文名称:
谱图信息:
最多检出来源 Macaca mulatta(otcml) 1.19%
分子结构信息
SMILES: CCCCCCCC(CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O)O
InChI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1
描述信息
(s)-hydroxydecanoyl-coa, also known as S-(3-hydroxydecanoate) CoA or 3S-hydroxy-decanoyl-CoA is an acyl-CoA or acyl-coenzyme A. More specifically, it is a 3-hydroxydecanoic acid thioester of coenzyme A. (s)-hydroxydecanoyl-coa is an acyl-CoA with 10 fatty acid group as the acyl moiety attached to coenzyme A. Coenzyme A was discovered in 1946 by Fritz Lipmann (Journal of Biological Chemistry (1946) 162 (3): 743–744) and its structure was determined in the early 1950s at the Lister Institute in London. Coenzyme A is a complex, thiol-containing molecule that is naturally synthesized from pantothenate (vitamin B5), which is found in various foods such as meat, vegetables, cereal grains, legumes, eggs, and milk. More specifically, coenzyme A (CoASH or CoA) consists of a beta-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3-phosphorylated ADP. Coenzyme A is synthesized in a five-step process that requires four molecules of ATP, pantothenate and cysteine. It is believed that there are more than 1100 types of acyl-CoA’s in the human body, which also corresponds to the number of acylcarnitines in the human body. Acyl-CoAs exists in all living species, ranging from bacteria to plants to humans. The general role of acyl-CoA’s is to assist in transferring fatty acids from the cytoplasm to mitochondria. This process facilitates the production of fatty acids in cells, which are essential in cell membrane structure. Acyl-CoAs are also susceptible to beta oxidation, forming, ultimately, acetyl-CoA. Acetyl-CoA can enter the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP -- or biochemical energy. Acyl-CoAs can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain acyl-CoAs; 2) medium-chain acyl-CoAs; 3) long-chain acyl-CoAs; and 4) very long-chain acyl-CoAs; 5) hydroxy acyl-CoAs; 6) branched chain acyl-CoAs; 7) unsaturated acyl-CoAs; 8) dicarboxylic acyl-CoAs and 9) miscellaneous acyl-CoAs. Short-chain acyl-CoAs have acyl-groups with two to four carbons (C2-C4), medium-chain acyl-CoAs have acyl-groups with five to eleven carbons (C5-C11), long-chain acyl-CoAs have acyl-groups with twelve to twenty carbons (C12-C20) while very long-chain acyl-CoAs have acyl groups with more than 20 carbons. (s)-hydroxydecanoyl-coa is therefore classified as a medium chain acyl-CoA. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase/synthase. Fatty acids are first converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase. Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. (s)-hydroxydecanoyl-coa, being a medium chain acyl-CoA is a substrate for medium chain acyl-CoA synthase. The second step of fatty acid degradation is beta oxidation. Beta oxidation occurs in mitochondria and, in the case of very long chain acyl-CoAs, the peroxisome. After its formation in the cytosol, (S)-Hydroxydecanoyl-CoA is transported into the mitochondria, the locus of beta oxidation. Transport of (S)-Hydroxydecanoyl-CoA into the mitochondria requires carnitine palmitoyltransferase 1 (CPT1), which converts (S)-Hydroxydecanoyl-CoA into 3-Hydroxydecanoylcarnitine, which gets transported into the mitochondrial matrix. Once in the matrix, 3-Hydroxydecanoylcarnitine is converted back to (S)-Hydroxydecanoyl-CoA by CPT2, whereupon beta-oxidation can begin. Beta oxidation of (S)-Hydroxydecanoyl-CoA occurs in four steps. First, since (S)-Hydroxydecanoyl-CoA is a medium chain acyl-CoA it is the substrate for a medium chain acyl-CoA dehydrogenase, which catalyzes dehydrogenation of (S)-Hydroxydecanoyl-CoA, creating a double bond between the alpha and beta carbons. FAD is the hydrogen acceptor, yielding FADH2. Second, Enoyl-CoA hydrase catalyzes the addition of water across the newly formed double bo...
(S)-Hydroxydecanoyl-CoA has a role in the synthesis and oxidation of fatty acids. It is involved in fatty acid elongation in mitochondria. In this pathway 3-Oxodecanoyl-CoA is acted upon by two enzymes, 3-hydroxyacyl-CoA dehydrogenase and long-chain-3-hydroxyacyl-CoA dehydrogenase to produce (S)-Hydroxydecanoyl-CoA. Since coenzyme A is chemically a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. It assists in transferring fatty acids from the cytoplasm to mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group it is usually referred to as CoASH or HSCoA. [HMDB]
同义名列表
19 个代谢物同义名
{[(2R,3R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-3-({2-[(2-{[(3S)-3-hydroxydecanoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)-2,2-dimethylpropoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid; 3-Hydroxydecanoyl-coenzyme A, (R)-isomer; DL-beta-Hydroxydecanoyl coenzyme A; S-(3-Hydroxydecanoate) coenzyme A; (S)-3-Hydroxydecanoyl-coenzyme A; S-(3-Hydroxydecanoate)coenzyme A; beta-Hydroxydecanoyl coenzyme A; DL-b-Hydroxydecanoyl coenzyme A; 3S-Hydroxy-decanoyl-coenzyme A; 3-Hydroxydecanoyl-coenzyme A; b-Hydroxydecanoyl coenzyme A; S-(3-Hydroxydecanoate) CoA; (S)-3-Hydroxydecanoyl-CoA; S-(3-Hydroxydecanoic acid; S-(3-Hydroxydecanoate)CoA; (S)-Hydroxydecanoyl-CoA; 3S-hydroxy-decanoyl-CoA; S-(3-Hydroxydecanoate; 3-Hydroxydecanoyl-CoA
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:28325
- KEGG: C05264
- PubChem: 11966158
- PubChem: 16061159
- PubChem: 5118003
- HMDB: HMDB0003938
- Metlin: METLIN36646
- foodb: FDB023257
- chemspider: 17220838
- CAS: 6245-70-1
- PMhub: MS000018628
- PubChem: 7651
- LipidMAPS: LMFA07050403
- PDB-CCD: HSC
- 3DMET: B04992
- NIKKAJI: J2.755.093B
分类词条
相关代谢途径
Reactome(6)
BioCyc(0)
PlantCyc(0)
代谢反应
167 个相关的代谢反应过程信息。
Reactome(90)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Fatty acid metabolism:
Ac-CoA + H2O ⟶ CH3COO- + CoA-SH
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + CoA + MCFA ⟶ AMP + MCFA-CoA + PPi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
(S)-3-hydroxypalmitoyl-CoA + NAD ⟶ 3-Oxopalmitoyl-CoA + H+ + NADH
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
(S)-Hydroxydecanoyl-CoA + NAD ⟶ 3-Oxodecanoyl-CoA + H+ + NADH
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
3-oxopristanoyl-CoA + CoA-SH ⟶ 4,8,12-trimethyltridecanoyl-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
ATP + BUT ⟶ AMP + BT-CoA + PPi
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Fatty acid metabolism:
Ac-CoA + H2O ⟶ CH3COO- + CoA-SH
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + CoA + MCFA ⟶ AMP + MCFA-CoA + PPi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
(S)-3-hydroxypalmitoyl-CoA + NAD ⟶ 3-Oxopalmitoyl-CoA + H+ + NADH
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
(S)-Hydroxydecanoyl-CoA + NAD ⟶ 3-Oxodecanoyl-CoA + H+ + NADH
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Mitochondrial Fatty Acid Beta-Oxidation:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN
BioCyc(0)
WikiPathways(3)
- Fatty acid beta-oxidation:
4-cis-dexeboyl-CoA ⟶ 2-trans-4-cis-decadienoyl-CoA
- Metabolism overview:
NH3 ⟶ Glutamic acid
- Fatty acid beta-oxidation:
4-cis-dexeboyl-CoA ⟶ 2-trans-4-cis-decadienoyl-CoA
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(74)
- Phospholipid Biosynthesis CL(16:1(9Z)/10:0(3-OH)/16:1(9Z)/10:0(3-OH)):
CDP-DG(16:1(9Z)/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(16:1(9Z)/10:0(3-OH))
- Phospholipid Biosynthesis CL(12:0/10:0(3-OH)/12:0/10:0(3-OH)):
CDP-DG(12:0/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(12:0/10:0(3-OH))
- Fatty Acid Metabolism:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Fatty Acid Elongation in Mitochondria:
(2E)-Hexenoyl-CoA + NADPH ⟶ Hexanoyl-CoA + NADP
- Ethylmalonic Encephalopathy:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Glutaric Aciduria Type I:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids:
Adenosine triphosphate + Coenzyme A + Dodecanoic acid ⟶ Adenosine monophosphate + Lauroyl-CoA + Pyrophosphate
- Carnitine Palmitoyl Transferase Deficiency I:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Carnitine Palmitoyl Transferase Deficiency II:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD):
(2E)-Hexenoyl-CoA + NADPH ⟶ Hexanoyl-CoA + NADP
- Trifunctional Protein Deficiency:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- fatty acid oxidation (Decanoate):
Adenosine triphosphate + Capric acid + Coenzyme A ⟶ Adenosine monophosphate + Decanoyl-CoA
- Fatty Acid Metabolism:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Fatty Acid Elongation In Mitochondria:
(2E)-Hexenoyl-CoA + NADPH ⟶ Hexanoyl-CoA + NADP
- Fatty Acid Metabolism:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Fatty Acid Elongation In Mitochondria:
Palmityl-CoA + Water ⟶ Coenzyme A + Palmitic acid
- Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids:
Adenosine triphosphate + Coenzyme A + Dodecanoic acid ⟶ Adenosine monophosphate + Lauroyl-CoA + Pyrophosphate
- Ethylmalonic Encephalopathy:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Carnitine Palmitoyl Transferase Deficiency I:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Carnitine Palmitoyl Transferase Deficiency II:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD):
Palmityl-CoA + Water ⟶ Coenzyme A + Palmitic acid
- Trifunctional Protein Deficiency:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Fatty Acid Metabolism:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Fatty Acid Elongation in Mitochondria:
Palmityl-CoA + Water ⟶ Coenzyme A + Palmitic acid
- Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids:
Adenosine triphosphate + Coenzyme A + Dodecanoic acid ⟶ Adenosine monophosphate + Lauroyl-CoA + Pyrophosphate
- Fatty Acid Metabolism:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Fatty Acid Elongation in Mitochondria:
Palmityl-CoA + Water ⟶ Coenzyme A + Palmitic acid
- Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids:
Adenosine triphosphate + Coenzyme A + Dodecanoic acid ⟶ Adenosine monophosphate + Lauroyl-CoA + Pyrophosphate
- Fatty Acid Metabolism:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids:
Adenosine triphosphate + Coenzyme A + Dodecanoic acid ⟶ Adenosine monophosphate + Lauroyl-CoA + Pyrophosphate
- Fatty Acid Metabolism:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids:
Adenosine triphosphate + Coenzyme A + Dodecanoic acid ⟶ Adenosine monophosphate + Lauroyl-CoA + Pyrophosphate
- Ethylmalonic Encephalopathy:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Carnitine Palmitoyl Transferase Deficiency I:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Carnitine Palmitoyl Transferase Deficiency II:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD):
Palmityl-CoA + Water ⟶ Coenzyme A + Palmitic acid
- Trifunctional Protein Deficiency:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
- Fatty Acid Elongation:
Water + hexadecanoyl-CoA ⟶ Coenzyme A + Palmitic acid
- Fatty Acid Oxidation (Decanoate):
Adenosine triphosphate + Capric acid + Coenzyme A ⟶ Adenosine monophosphate + Decanoyl-CoA
- Phospholipid Biosynthesis CL(18:1(9Z)/10:0(3-OH)/18:1(9Z)/10:0(3-OH)):
CDP-DG(18:1(9Z)/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(18:1(9Z)/10:0(3-OH))
- Phospholipid Biosynthesis CL(10:0(3-OH)/10:0/10:0(3-OH)/10:0):
CDP-DG(10:0(3-OH)/10:0) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/10:0)
- Phospholipid Biosynthesis CL(10:0(3-OH)/12:0(3-OH)/10:0(3-OH)/12:0(3-OH)):
CDP-DG(10:0(3-OH)/12:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/12:0(3-OH))
- Phospholipid Biosynthesis CL(10:0(3-OH)/12:0/10:0(3-OH)/12:0):
CDP-DG(10:0(3-OH)/12:0) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/12:0)
- Phospholipid Biosynthesis CL(10:0(3-OH)/15:0cycw5/10:0(3-OH)/15:0cycw5):
CDP-DG(10:0(3-OH)/15:0cycw5) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/15:0cycw5)
- Phospholipid Biosynthesis CL(10:0(3-OH)/16:1(9Z)/10:0(3-OH)/16:1(9Z)):
CDP-DG(10:0(3-OH)/16:1(9Z)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/16:1(9Z))
- Phospholipid Biosynthesis CL(10:0(3-OH)/16:0/10:0(3-OH)/16:0):
CDP-DG(10:0(3-OH)/16:0) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/16:0)
- Phospholipid Biosynthesis CL(10:0(3-OH)/17:0cycw7/10:0(3-OH)/17:0cycw7):
CDP-DG(10:0(3-OH)/17:0cycw7) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/17:0cycw7)
- Phospholipid Biosynthesis CL(10:0(3-OH)/17:0cycw7/14:0/14:0):
CDP-DG(10:0(3-OH)/17:0cycw7) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/17:0cycw7)
- Phospholipid Biosynthesis CL(10:0(3-OH)/19:0cycw7/10:0(3-OH)/19:0cycw7):
CDP-DG(10:0(3-OH)/19:0cycw7) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/19:0cycw7)
- Phospholipid Biosynthesis CL(10:0(3-OH)/i-19:0/10:0(3-OH)/i-19:0):
CDP-DG(10:0(3-OH)/i-19:0) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0(3-OH)/i-19:0)
- Phospholipid Biosynthesis CL(10:0/10:0(3-OH)/10:0/10:0(3-OH)):
CDP-DG(10:0/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(10:0/10:0(3-OH))
- Phospholipid Biosynthesis CL(12:0(3-OH)/10:0(3-OH)/12:0(3-OH)/10:0(3-OH)):
CDP-DG(12:0(3-OH)/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(12:0(3-OH)/10:0(3-OH))
- Phospholipid Biosynthesis CL(15:0/10:0(3-OH)/15:0/10:0(3-OH)):
CDP-DG(15:0/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(15:0/10:0(3-OH))
- Phospholipid Biosynthesis CL(15:0cycw5/10:0(3-OH)/15:0cycw5/10:0(3-OH)):
CDP-DG(15:0cycw5/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(15:0cycw5/10:0(3-OH))
- Phospholipid Biosynthesis CL(16:0/10:0(3-OH)/16:0/10:0(3-OH)):
CDP-DG(16:0/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(16:0/10:0(3-OH))
- Phospholipid Biosynthesis CL(17:0cycw7/10:0(3-OH)/10:0/10:0):
CDP-DG(17:0cycw7/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(17:0cycw7/10:0(3-OH))
- Phospholipid Biosynthesis CL(17:0cycw7/10:0(3-OH)/14:0/14:0):
CDP-DG(17:0cycw7/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(17:0cycw7/10:0(3-OH))
- Phospholipid Biosynthesis CL(17:0cycw7/10:0(3-OH)/17:0cycw7/10:0(3-OH)):
CDP-DG(17:0cycw7/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(17:0cycw7/10:0(3-OH))
- Phospholipid Biosynthesis CL(19:0cycw7/10:0(3-OH)/10:0/10:0):
CDP-DG(19:0cycw7/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(19:0cycw7/10:0(3-OH))
- Phospholipid Biosynthesis CL(19:0cycw7/10:0(3-OH)/19:0cycw7/10:0(3-OH)):
CDP-DG(19:0cycw7/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(19:0cycw7/10:0(3-OH))
- Phospholipid Biosynthesis CL(i-19:0/10:0(3-OH)/10:0/10:0):
CDP-DG(i-19:0/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(i-19:0/10:0(3-OH))
- Phospholipid Biosynthesis CL(i-19:0/10:0(3-OH)/i-19:0/10:0(3-OH)):
CDP-DG(i-19:0/10:0(3-OH)) + L-Serine ⟶ Cytidine monophosphate + Hydrogen Ion + PS(i-19:0/10:0(3-OH))
PharmGKB(0)
3 个相关的物种来源信息
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。