N-methylproline (BioDeep_00000000729)
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
化学式: C6H11NO2 (129.079)
中文名称: 古柯叶液碱酸, 古液酸, 1-甲基吡咯烷-2-甲酸, N-甲基L-脯氨酸, N-甲基- L -脯氨酸
谱图信息:
最多检出来源 Homo sapiens(lipidsearch) 38.94%
Last reviewed on 2024-09-14.
Cite this Page
N-methylproline. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/n-methylproline (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000000729). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1CC[C@H](N1C)C(=O)O
InChI: InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)
描述信息
N-Methyl-L-proline, also known as N-methyl-L-proline, (2S)-1-methylpyrrolidine-2-carboxylic acid, hydric acid, or monomethyl proline, is classified as a proline or a proline derivative. It is not naturally produced by humans and can only be obtained from the diet. In particular, it is a metabolically inert cell protectant found in many plants and is used by plants to protect against extremes in osmolarity and growth temperatures. N-Methyl-L-proline is found in the fruit juices of yellow orange, blood orange, lemon, mandarin, and bitter orange (PMID: 21838291).
N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion.
An L-proline derivative obtained by replacement of the amino hydrogen by a methyl group.
Hygric acid (N-Methyl-L-proline) is a proline analogue found in the citrus juices and the juice of bergamot[1].
同义名列表
31 个代谢物同义名
(2S)-1-methylpyrrolidin-1-ium-2-carboxylate; (2S)-1-methylpyrrolidine-2-carboxylic acid; (S)-1-Methyl-pyrrolidine-2-carboxylic acid; (2S)-1-Methyl-2-pyrrolidinecarboxylic acid; (S)-1-methylpyrrolidine-2-carboxylic acid; (2S)-1-Methylpyrrolidine-2-carboxylate; N-methylpyrrolidine-2-carboxylic acid; N-methylpyrrolidine-2-carboxylate; CWLQUGTUXBXTLF-YFKPBYRVSA-N; n-alpha-methyl-l-proline; (-)-N-Methyl-L-proline; N-methyl (L)-proline; L-Proline, 1-methyl-; 1-methyl-L-proline; N-Methyl-L-proline; Monomethyl proline; (-)-Hygrinic acid; (S)-methylproline; N-methyl proline; methyl-l-proline; (-)-Hygric acid; N-methylproline; 1-Methylproline; MePro-OH.nH2O; Hygrinic acid; h-n-me-pro-oh; methylproline; Hygric acid; 3BY; 1-methylpyrrolidine-2-carboxylic acid; N-Methyl-L-proline
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:90344
- KEGG: C22223
- PubChem: 643474
- PubChem: 557
- HMDB: HMDB0094696
- MeSH: N-methylproline
- MetaCyc: CPD-904
- KNApSAcK: C00034881
- chemspider: 558617
- CAS: 475-11-6
- medchemexpress: HY-21754
- PMhub: MS000007666
- MetaboLights: MTBLC90344
- PubChem: 405226414
- PDB-CCD: 3BY
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Usman A Tahir, Daniel H Katz, Tianyi Zhao, Debby Ngo, Daniel E Cruz, Jeremy M Robbins, Zsu-Zsu Chen, Bennet Peterson, Mark D Benson, Xu Shi, Lucas Dailey, Charlotte Andersson, Ramachandran S Vasan, Yan Gao, Changyu Shen, Adolfo Correa, Michael E Hall, Thomas J Wang, Clary B Clish, James G Wilson, Robert E Gerszten. Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study.
Circulation. Heart failure.
2021 01; 14(1):e007275. doi:
10.1161/circheartfailure.120.007275. [PMID: 33464957] - Julian M Gaitán, Hyo Youl Moon, Matthew Stremlau, Dena B Dubal, Dane B Cook, Ozioma C Okonkwo, Henriette van Praag. Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease.
Frontiers in endocrinology.
2021; 12(?):660181. doi:
10.3389/fendo.2021.660181. [PMID: 34093436] - Luigi Servillo, Alfonso Giovane, Maria Luisa Balestrieri, Domenico Cautela, Domenico Castaldo. Proline derivatives in fruits of bergamot (Citrus bergamia Risso et Poit): presence of N-methyl-L-proline and 4-hydroxy-L-prolinebetaine.
Journal of agricultural and food chemistry.
2011 Jan; 59(1):274-81. doi:
10.1021/jf102833v. [PMID: 21128667] - Mouhssin Oufir, Nadine Schulz, Patan Shaik Sha Vallikhan, Eva Wilhelm, Kornel Burg, Jean-Francois Hausman, Lucien Hoffmann, Cedric Guignard. Simultaneous measurement of proline and related compounds in oak leaves by high-performance ligand-exchange chromatography and electrospray ionization mass spectrometry for environmental stress studies.
Journal of chromatography. A.
2009 Feb; 1216(7):1094-9. doi:
10.1016/j.chroma.2008.12.030. [PMID: 19135675] - R Mungur, A D M Glass, D B Goodenow, D A Lightfoot. Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene.
Journal of biomedicine & biotechnology.
2005 Jun; 2005(2):198-214. doi:
10.1155/jbb.2005.198. [PMID: 16046826] - Satoe Kobayashi, Akinori Chikushi, Shiho Tougu, Yuichi Imura, Minoru Nishida, Yoshiaki Yano, Katsumi Matsuzaki. Membrane translocation mechanism of the antimicrobial peptide buforin 2.
Biochemistry.
2004 Dec; 43(49):15610-6. doi:
10.1021/bi048206q. [PMID: 15581374]
