Chemical Formula: C6H13O9P
Chemical Formula C6H13O9P
Found 164 metabolite its formula value is C6H13O9P
Glucose 6-phosphate
Glucose 6 phosphate (alpha-D-glucose 6 phosphate or G6P) is the alpha-anomer of glucose-6-phosphate. There are two anomers of glucose 6 phosphate, the alpha anomer and the beta anomer. Glucose 6 phosphate is an ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed). Glucose-6-phosphate is a phosphorylated glucose molecule on carbon 6. When glucose enters a cell, it is immediately phosphorylated to G6P. This is catalyzed with hexokinase enzymes, thus consuming one ATP. A major reason for immediate phosphorylation of the glucose is so that it cannot diffuse out of the cell. The phosphorylation adds a charged group so the G6P cannot easily cross cell membranes. G6P can travel down two metabolic pathways, glycolysis and the pentose phosphate pathway. In addition to the metabolic pathways, G6P can also be stored as glycogen in the liver if blood glucose levels are high. If the body needs energy or carbon skeletons for syntheses, G6P can be isomerized to Fructose-6-phosphate and then phosphorylated to Fructose-1,6-bisphosphate. Note, the molecule now has 2 phosphoryl groups attached. The addition of the 2nd phosphoryl group is an irreversible step, so once this happens G6P will enter glycolysis and be turned into pyruvate (ATP production occurs). If blood glucose levels are high, the body needs a way to store the excess glucose. After being converted to G6P, phosphoglucose mutase (isomerase) can turn the molecule into glucose-1-phosphate. Glucose-1-phosphate can then be combined with uridine triphosphate (UTP) to form UDP-glucose. This reaction is driven by the hydrolysis of pyrophosphate that is released in the reaction. Now, the activated UDP-glucose can add to a growing glycogen molecule with the help of glycogen synthase. This is a very efficient storage mechanism for glucose since it costs the body only 1 ATP to store the 1 glucose molecule and virtually no energy to remove it from storage. It is important to note that glucose-6-phosphate is an allosteric activator of glycogen synthase, which makes sense because when the level of glucose is high the body should store the excess glucose as glycogen. On the other hand, glycogen synthase is inhibited when it is phosphorylated by protein kinase a during times of high stress or low blood glucose levels. -- Wikipedia [HMDB] Glucose 6-phosphate (G6P, sometimes called the Robison ester) is a glucose sugar phosphorylated at the hydroxy group on carbon 6. Glucose 6-phosphate (G6P) has two anomers: the alpha anomer and the beta anomer. Glucose 6-phosphate is an ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose 6-phosphate (Stedman, 26th ed). When glucose enters a cell, it is immediately phosphorylated to G6P. This is catalyzed with hexokinase enzymes, thus consuming one ATP. A major reason for immediate phosphorylation of the glucose is so that it cannot diffuse out of the cell. The phosphorylation adds a charged group so the G6P cannot easily cross cell membranes. G6P can travel down two metabolic pathways: glycolysis and the pentose phosphate pathway. In addition to the metabolic pathways, G6P can also be stored as glycogen in the liver if blood glucose levels are high. If the body needs energy or carbon skeletons for syntheses, G6P can be isomerized to fructose 6-phosphate and then phosphorylated to fructose 1,6-bisphosphate. Note, the molecule now has 2 phosphoryl groups attached. The addition of the 2nd phosphoryl group is an irreversible step, so once this happens G6P will enter glycolysis and be turned into pyruvate (ATP production occurs). If blood glucose levels are high, the body needs a way to store the excess glucose. After being converted to G6P, phosphoglucose mutase (an isomerase) can turn the molecule into glucose 1-phosphate. Glucose 1-phosphate can then be combined with uridine triphosphate (UTP) to form UDP-glucose. This reaction is driven by the hydrolysis of pyrophosphate that is released in the reaction. Now, the activated UDP-glucose can add to a growing glycogen molecule with the help of glycogen synthase. This is a very efficient storage mechanism for glucose since it costs the body only 1 ATP to store the 1 glucose molecule and virtually no energy to remove it from storage. It is important to note that glucose 6-phosphate is an allosteric activator of glycogen synthase, which makes sense because when the level of glucose is high the body should store the excess glucose as glycogen. On the other hand, glycogen synthase is inhibited when it is phosphorylated by protein kinase during times of high stress or low blood glucose levels. Acquisition and generation of the data is financially supported in part by CREST/JST. CONFIDENCE standard compound; INTERNAL_ID 237 KEIO_ID G003; [MS2] KO009109 KEIO_ID G003
α-D-Glucose-1-phosphate
Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1-carbon. It can exist in either the α- or β-anomeric form. Glucose 1-phosphate belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. Glucose 1-phosphate is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose from a greater glycogen structure. It cannot travel down many metabolic pathways and must be interconverted by the enzyme phosphoglucomutase in order to become glucose 6-phosphate. Free glucose 1-phosphate can also react with UTP to form UDP-glucose. It can then return to the greater glycogen structure via glycogen synthase. *Found widely in both plants and animals. A precursor of starch in plants and of glycogen in animals. [CCD] Acquisition and generation of the data is financially supported in part by CREST/JST. COVID info from COVID-19 Disease Map KEIO_ID G020 Corona-virus KEIO_ID G115 Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
Sorbose 1-phosphate
Sorbose 1-phosphate is formed when extracellular sorbose is taken into the cell. The enzyme responsible for this is PTS-Sor-EIIA [EC:2.7.1.69]. Sorbose 1-phosphate has been found to be a metabolite of Klebsiella and Lactobacillus (PMID: 6361004; PMID: 12177329). Sorbose 1-phosphate is formed when extracellular sorbose is taken into the cell. The enzyme responsible for this is PTS-Sor-EIIA [EC:2.7.1.69]. [HMDB]
β-D-Fructose 6-phosphate
Fructose 6-phosphate (F6P) belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. F6P is a derivative of fructose, which has been phosphorylated at the 6-hydroxy group. Fructose 6-phosphate is a fundamental metabolite and exists in all living species, ranging from bacteria to plants to humans. The great majority of glucose is converted to fructose 6-phosphate as part of the glycolytic metabolic pathway (glycolysis). Specifically, F6P is produce is produced by the isomerisation of glucose 6-phosphate via the enzyme phosphoglucose isomerase. F6P is in turn further phosphorylated to fructose-1,6-bisphosphate by the enzyme phosphofructokinase-1. Glycolysis is the metabolic pathway that converts glucose into pyruvic acid. The free energy released in this process is used to form ATP and reduced nicotinamide adenine dinucleotide (NADH). In addition to its key involvement in glycolysis, fructose 6-phosphate can also be biosynthesized from glucosamine 6-phosphate via the enzyme glucosamine-6-phosphate isomerase 1. In addition, fructose 6-phosphate and L-glutamine can be converted into glucosamine 6-phosphate and L-glutamic acid through the action of the enzyme glutamine--fructose-6-phosphate aminotransferase. An important intermediate in the Carbohydrates pathway. The interconversion of glucose-6-phosphate and fructose-6-phosphate, the second step of the Embden-Meyerhof glycolytic pathway, is catalyzed by the enzyme phosphoglucose isomerase (PGI). In gluconeogenesis, fructose-6-phosphate is the immediate precursor of glucose-6-phosphate (wikipedia) [HMDB] Acquisition and generation of the data is financially supported in part by CREST/JST. KEIO_ID F001
Fructose 1-phosphate
Fructose 1-phosphate, also known as D-fructose-1-p, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Metabolism of fructose thus essentially results in intermediates of glycolysis. The final product of glycolysis (pyruvate) may then undergo gluconeogenesis, enter the TCA cycle or be stored as fatty acids. Fructose 1-phosphate exists in all living organisms, ranging from bacteria to humans. Within humans, fructose 1-phosphate participates in a number of enzymatic reactions. In particular, fructose 1-phosphate can be biosynthesized from D-fructose through the action of the enzyme ketohexokinase. In addition, fructose 1-phosphate can be converted into dihydroxyacetone phosphate and glyceraldehyde; which is catalyzed by the enzyme fructose-bisphosphate aldolase a. Because fructokinase has a high Vmax fructose entering cells is quickly phosphorylated to fructose 1-phosphate. In humans, fructose 1-phosphate is involved in fructose intolerance, hereditary. Hypoglycemia results from inhibition of glycogenolysis and gluconeogenesis. It is generated mainly by hepatic fructokinase but is also generated in smaller amounts in the small intestinal mucosa and proximal epithelium of the renal tubule. Aldolase B converts it into glyceraldehyde and dihydroxyacetone phosphate (DHAP). Symptoms of hereditary fructose intolerance are apathy, drowsiness, sweatiness and tremulousness. Fructose 1-phosphate is an intermediate metabolite in the Fructose and mannose metabolism pathway. [HMDB] KEIO_ID F009
myo-Inositol 1-phosphate
myo-Inositol 1-phosphate, also known as I1P or ins(1)p, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. myo-Inositol 1-phosphate is a metabolite of inositol phosphate metabolism and the phosphatidylinositol signalling system. Inositol phosphatases (EC:3.1.3.25) play a crucial role in the phosphatidylinositol signalling pathway. Expression is substantially higher in the subcortical regions of the brain, most prominently in the caudate. The phosphatidylinositol pathway is thought to be modified by lithium, a commonly prescribed medication in treating bipolar disorder (OMIM: 605922). Myo-inositol 1-phosphate is a metabolite of the Inositol phosphate metabolism and the Phosphatidylinositol signaling system. Inositol phosphatases [EC:3.1.3.25] play a crucial role in the phosphatidylinositol signaling pathway; in brain, the expression is substantially higher in the subcortical regions, most prominently in the caudate. The phosphatidylinositol pathway is thought to be modified by lithium, a commonly prescribed medication in treating bipolar disorder. (OMIM 605922) [HMDB]
Beta-D-Fructose 2-phosphate
beta-D-Fructose 2-phosphate is involved in the fructose eand mannose system. beta-D-Fructose 2-phosphate is produced from beta-D-Fructose 2,6-bisphosphate by the enzyme fructose-2,6-bisphosphate 6-phosphatase [EC 3.1.3.54]. [HMDB] beta-D-Fructose 2-phosphate is involved in the fructose eand mannose system. beta-D-Fructose 2-phosphate is produced from beta-D-Fructose 2,6-bisphosphate by the enzyme fructose-2,6-bisphosphate 6-phosphatase [EC 3.1.3.54].
Galactose 1-phosphate
Galactose 1-phosphate, also known as D-Galactose-1-phosphate or alpha-D-gal-1-P, belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphate group linked to the carbohydrate unit. Galactose-1-phosphate is an intermediate in the interconversion of glucose and uridine diphosphate galactose. Galactose 1-phosphate exists in all living species, ranging from bacteria to plants to humans. Within humans, galactose 1-phosphate participates in a number of enzymatic reactions. In particular, uridine diphosphate glucose and galactose 1-phosphate can be biosynthesized from uridine diphosphategalactose and glucose 1-phosphate; which is mediated by the enzyme galactose-1-phosphate uridylyltransferase (GALT). In addition, galactose 1-phosphate can be biosynthesized from D-galactose through the action of the enzyme galactokinase. The improper metabolism of galactose-1-phosphate is a characteristic of a condition known as galactosemia (PMID: 7671964). Type I galactosemia is a genetic disorder that is caused by the impairment of galactose-1-phosphate uridylyltransferase (EC 2.7.7.12). Evidence suggests that misfolding of the galactose 1-phosphate uridylyltransferase enzyme is the underlying cause of type I galactosemia (PMID: 23583749). Outside of the human body, galactose 1-phosphate has been detected, but not quantified in, several different foods, such as gooseberries, anises, turmerics, caraway, and cumins. COVID info from COVID-19 Disease Map Occurs in liver, milk, and yeasts Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS Acquisition and generation of the data is financially supported in part by CREST/JST.
Mannose 6-phosphate
Mannose 6-phosphate, also known as alpha-D-mannose-6-p or man-6-p, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Mannose 6-phosphate exists in all eukaryotes, ranging from yeast to humans. Within humans, mannose 6-phosphate participates in a number of enzymatic reactions. In particular, mannose 6-phosphate can be converted into fructose 6-phosphate through its interaction with the enzyme mannose-6-phosphate isomerase. In addition, mannose 6-phosphate can be biosynthesized from D-mannose through the action of the enzyme hexokinase-1. Mannose 6-phosphate is a potent competitive inhibitor of pinocytosis of human platelet beta-glucuronidase and it is a necessary component of the recognition marker on the enzyme for pinocytosis by human fibroblasts as well (PMID 908752). In humans, mannose 6-phosphate is involved in fructose intolerance, hereditary. Mannose-6-phosphate is a potent competitive inhibitor of pinocytosis of human platelet beta-glucuronidase and it is a necessary component of the recognition marker on the enzyme for pinocytosis by human fibroblasts as well (PMID 908752). [HMDB] Acquisition and generation of the data is financially supported in part by CREST/JST. KEIO_ID M008
D-myo-Inositol 4-phosphate
D-myo-Inositol 4-phosphate, also known as inositol 4-phosphoric acid, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. D-myo-Inositol 4-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Within humans, D-myo-inositol 4-phosphate participates in a number of enzymatic reactions. In particular, D-myo-inositol 4-phosphate can be biosynthesized from D-myo-inositol 1,4-bisphosphate through its interaction with the enzyme inositol polyphosphate 1-phosphatase. In addition, D-myo-inositol 4-phosphate can be converted into myo-inositol through its interaction with the enzyme inositol monophosphatase 1. D-Myo-inositol 4-phosphate is a substrate for Inositol monophosphatase, Inositol polyphosphate 1-phosphatase and Inositol monophosphatase 2. [HMDB]
beta-D-Glucose 6-phosphate
beta-D-Glucose 6 phosphate (b-G6P) is the beta-anomer of glucose-6-phosphate. There are two anomers of glucose 6 phosphate: the alpha anomer and the beta anomer. Specifically, beta-D-Glucose 6-phosphate is glucose sugar phosphorylated on carbon 6. It is a very common metabolite in cells as the vast majority of glucose entering a cell will become phosphorylated in this way. The primary reason for the immediate phosphorylation of glucose is to prevent diffusion out of the cell. The phosphorylation adds a charged phosphate group so the glucose 6-phosphate cannot easily cross the cell membrane. b-G6P is involved in glycolysis, gluconeogenesis, pentose phosphate, and glycogen and sucrose metabolic pathways. beta-D-Glucose 6 phosphate can be generated through beta-D-fructose phosphate or alpha-D-glucose 6 phosphate (via glucose-6-phosphate isomerase) or beta-D glucose (via hexokinase). It can then be sent off to the pentose phosphate pathway which generates the useful cofactor NADPH as well as ribulose 5-phosphate, a carbon source for the synthesis of other molecules. Alternately, if the cell needs energy or carbon skeletons for synthesis then glucose 6-phosphate is targeted for glycolysis. A third route is to have glucose 6 phosphate stored or converted into glycogen, especially if blood glucose levels are high. Beta-d-glucose 6-phosphate, also known as B-D-glucose 6-(dihydrogen phosphoric acid) or 6-O-phosphono-beta-D-glucopyranose, is a member of the class of compounds known as hexose phosphates. Hexose phosphates are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Beta-d-glucose 6-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). Beta-d-glucose 6-phosphate can be found in a number of food items such as sapodilla, hickory nut, atlantic herring, and swede, which makes beta-d-glucose 6-phosphate a potential biomarker for the consumption of these food products. Beta-d-glucose 6-phosphate exists in all living species, ranging from bacteria to humans. In humans, beta-d-glucose 6-phosphate is involved in several metabolic pathways, some of which include glycolysis, glycogenosis, type IC, glycogenosis, type IB, and trehalose degradation. Beta-d-glucose 6-phosphate is also involved in several metabolic disorders, some of which include glucose-6-phosphate dehydrogenase deficiency, warburg effect, fanconi-bickel syndrome, and transaldolase deficiency.
Beta-D-Fructose 6-phosphate
Beta-D-Fructose 6 phosphate (b-F6P) is the beta-anomer of fructose-6-phosphate. There are two anomers of fructose 6 phosphate, the alpha anomer and the beta anomer. Specifically, beta-D-fructose 6-phosphate is fructose sugar phosphorylated on carbon 6. Beta-D-Fructose 6-phosphate is a substrate for Fructose-1,6-bisphosphatase, Pyruvate kinase (isozymes R/L), Hexokinase (type I), Fructose-bisphosphate aldolase A, L-lactate dehydrogenase B chain, Glyceraldehyde-3-phosphate dehydrogenase (liver) and Transaldolase. [HMDB] Beta-D-Fructose 6 phosphate (b-F6P) is the beta-anomer of fructose-6-phosphate. There are two anomers of fructose 6 phosphate, the alpha anomer and the beta anomer. Specifically, beta-D-fructose 6-phosphate is fructose sugar phosphorylated on carbon 6. Beta-D-Fructose 6-phosphate is a substrate for Fructose-1,6-bisphosphatase, Pyruvate kinase (isozymes R/L), Hexokinase (type I), Fructose-bisphosphate aldolase A, L-lactate dehydrogenase B chain, Glyceraldehyde-3-phosphate dehydrogenase (liver) and Transaldolase.
D-Mannose 1-phosphate
D-Mannose 1-phosphate (CAS: 27251-84-9) is a normal metabolite intermediate in fructose and mannose metabolism. It is a substrate of phosphomannomutase 1 (PMM, EC 5.4.2.8), an enzyme necessary for the synthesis of GDP-mannose (a substrate for dolichol-linked oligosaccharide synthesis). PMM converts mannose 6-phosphate into mannose-1-phosphate. A deficiency of phosphomannomutase in carbohydrate-deficient glycoprotein syndrome (CDGS) type I is associated with a decreased synthesis of mannose 1-phosphate. CDGS is a group of autosomal recessively transmitted disorders in which abnormally glycosylated proteins are formed (PMID: 9451026, 8549746, 12729595). α-d-mannose 1-phosphate is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. α-d-mannose 1-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). α-d-mannose 1-phosphate can be found in a number of food items such as lettuce, beech nut, red beetroot, and japanese pumpkin, which makes α-d-mannose 1-phosphate a potential biomarker for the consumption of these food products. Acquisition and generation of the data is financially supported in part by CREST/JST. KEIO_ID M080
D-myo-Inositol 3-phosphate
D-myo-Inositol 3-phosphate, also known as inositol 3-phosphoric acid, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. D-myo-Inositol 3-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). D-myo-Inositol 3-phosphate is involved in the inositol phosphate metabolism and the phosphatidylinositol signalling systems. D-myo-Inositol 3-phosphate is created from D-myo-inositol 3,4-bisphosphate by inositol polyphosphate-4-phosphatase (EC 3.1.3.66) and is converted into myo-inositol by myo-inositol-1(or 4)-monophosphatase (EC 3.1.3.25). Myo-inositol 1-phosphate is a metabolite of the Inositol phosphate metabolism and the Phosphatidylinositol signaling system. Inositol phosphatases [EC:3.1.3.25] play a crucial role in the phosphatidylinositol signaling pathway; in brain, the expression is substantially higher in the subcortical regions, most prominently in the caudate. The phosphatidylinositol pathway is thought to be modified by lithium, a commonly prescribed medication in treating bipolar disorder. (OMIM 605922) [HMDB]
D-Tagatose 6-phosphate
D-Tagatose 6-phosphate is an intermediate in galactose metabolism. [HMDB] D-Tagatose 6-phosphate is an intermediate in galactose metabolism.
[(2R,3R,4S,5S)-3,4,5,6-Tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
alpha-D-Glucose 6-phosphate
A D-glucopyranose 6-phosphate where alpha-D-glucose is the sugar component. [Spectral] alpha-D-Glucose 6-phosphate (exact mass = 260.02972) and L-Isoleucine (exact mass = 131.09463) and 3-Sulfino-L-alanine (exact mass = 153.00958) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions. [Spectral] alpha-D-Glucose 6-phosphate (exact mass = 260.02972) and 3-Sulfino-L-alanine (exact mass = 153.00958) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Galactose 1-phosphate
A D-galactopyranose 1-phosphate having alpha-configuration at the anomeric centre. COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS α-d-galactose 1-phosphate, also known as alpha-D-galactopyranosyl phosphate or A-D-galactopyranose 1-phosphoric acid, is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. α-d-galactose 1-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). α-d-galactose 1-phosphate can be found in a number of food items such as kai-lan, cinnamon, macadamia nut (m. tetraphylla), and durian, which makes α-d-galactose 1-phosphate a potential biomarker for the consumption of these food products. α-d-galactose 1-phosphate can be found primarily in blood, as well as in human erythrocyte and red blood cell tissues. α-d-galactose 1-phosphate exists in all living species, ranging from bacteria to humans. In humans, α-d-galactose 1-phosphate is involved in few metabolic pathways, which include galactose metabolism, lactose synthesis, and nucleotide sugars metabolism. α-d-galactose 1-phosphate is also involved in several metabolic disorders, some of which include GLUT-1 deficiency syndrome, congenital disorder of glycosylation cdg-iid, galactosemia III, and galactosemia.
[(2R,3S,4R)-3,4,5-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl dihydrogen phosphate
L-tagatofuranose 6-phosphate
The furanose form of L-tagatose 6-phosphate.
L-Galactose 1-phosphate
A galactose phosphate compound with undefined anomeric stereochemistry having L-configuration and the phosphate group at the 1-position. A L-galactose 1-phosphate compound having beta-configuration about the anomeric centre.
D-Tagatose 1-phosphate
D-tagatose is a stereoisomer of D-fructose, which is phosphorylated to D-tagatose-1-phosphate by fructokinase in the liver. Slow degradation rate of D-tagatose-1-phosphate, cause accumulation, and ingested D-tagatose may therefore cause a longer lasting reduction in inorganic phosphate (Pi) and adenosine triphosphate (ATP) levels in the liver compared with D-fructose. It is also seen in patients with hereditary fructose intolerance, this may increase purine nucleotide degradation and thereby increase uric acid production. (PMID: 11079825) [HMDB] D-tagatose is a stereoisomer of D-fructose, which is phosphorylated to D-tagatose-1-phosphate by fructokinase in the liver. Slow degradation rate of D-tagatose-1-phosphate, cause accumulation, and ingested D-tagatose may therefore cause a longer lasting reduction in inorganic phosphate (Pi) and adenosine triphosphate (ATP) levels in the liver compared with D-fructose. It is also seen in patients with hereditary fructose intolerance, this may increase purine nucleotide degradation and thereby increase uric acid production. (PMID: 11079825).
Dolichyl phosphate D-mannose
Dolichyl phosphate D-mannose (DPM) is an intermediate in the biosynthesis of N-glycans. It is a substrate for dolichol-phosphate mannosyltransferase (PMID: 10835346). Dolichol-phosphate mannosyltransferase is a heterotrimeric protein embedded in the endoplasmic reticulum membrane. The first subunit of the heterotrimer appears to be the actual catalyst, and the other two subunits appear to stabilize it. More specifically, dolichol-phosphate-mannose is the donor of mannose groups in the synthesis of the dolichol pyrophosphate-linked precursor oligosaccharide in asparagine-linked glycosylation, in the synthesis of glycosyl phosphatidylinositol (GPI) anchor precursors, in protein O-mannosylation and in protein C-mannosylation. Its synthesis proceeds in two steps. First, cytosolic GDP-mannose reacts with dolichol phosphate exposed on the cytosolic face of the endoplasmic reticulum membrane to form DPM with its mannose moiety oriented toward the cytosol. The DPM molecule then flips in the endoplasmic reticulum membrane, so that its mannose moiety is in the endoplasmic reticulum lumen, accessible to the enzymes that catalyze its transfer to growing glycolipids and glycoproteins. (PMID: 11102867). Dolichyl phosphate D-mannose is also a substrate for protein O-mannosyl-transferase 2 and protein O-mannosyl-transferase 1. [HMDB] Dolichyl phosphate D-mannose (DPM) is an intermediate in the biosynthesis of N-glycans. It is a substrate for dolichol-phosphate mannosyltransferase (PMID: 10835346). Dolichol-phosphate mannosyltransferase is a heterotrimeric protein embedded in the endoplasmic reticulum membrane. The first subunit of the heterotrimer appears to be the actual catalyst, and the other two subunits appear to stabilize it. More specifically, dolichol-phosphate-mannose is the donor of mannose groups in the synthesis of the dolichol pyrophosphate-linked precursor oligosaccharide in asparagine-linked glycosylation, in the synthesis of glycosyl phosphatidylinositol (GPI) anchor precursors, in protein O-mannosylation and in protein C-mannosylation. Its synthesis proceeds in two steps. First, cytosolic GDP-mannose reacts with dolichol phosphate exposed on the cytosolic face of the endoplasmic reticulum membrane to form DPM with its mannose moiety oriented toward the cytosol. The DPM molecule then flips in the endoplasmic reticulum membrane, so that its mannose moiety is in the endoplasmic reticulum lumen, accessible to the enzymes that catalyze its transfer to growing glycolipids and glycoproteins. (PMID: 11102867). Dolichyl phosphate D-mannose is also a substrate for protein O-mannosyl-transferase 2 and protein O-mannosyl-transferase 1.
myo-Inositol 6-phosphate
myo-Inositol 6-phosphate, also known as I6P or Ins(6)P, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. Inositol phosphate is an intermediate step in the metabolism of glucose-6-phosphate into myo-inositol. myo-Inositol is synthesized from glucose-6-phosphate (G-6-P) in two steps. First, G-6-P is isomerized by INYNA1 into myo-inositol 1-phosphate, which is then dephosphorylated by IMPA1 to give myo-inositol. An intermediate step in the metabolism of glucose-6-phosphate to myo-inositol. myo-Inositol is synthesized from glucose-6-phosphate (G-6-P) in two steps. First, G-6-P is isomerised by INYNA1 to myo-inositol 1-phosphate, which is then dephosphorylated by IMPA1 to give myo-inositol [HMDB]
D-fructose 1-phosphate
D-fructose 1-phosphate, also known as 1-O-phosphono-D-fructose or fructose-1-phosphate, barium salt, (D)-isomer, is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. D-fructose 1-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). D-fructose 1-phosphate can be found in a number of food items such as rye, ucuhuba, sugar apple, and spelt, which makes D-fructose 1-phosphate a potential biomarker for the consumption of these food products. D-fructose 1-phosphate exists in all eukaryotes, ranging from yeast to humans. This compound belongs to the family of Monosaccharide Phosphates. These are monosaccharides comprising a phosphated group linked tot he carbohydrate unit.
(2,3,4,5,6-Pentahydroxycyclohexyl) dihydrogen phosphate
(2R,3R,4S,5R)-2,3,4,5-Tetrahydroxy-6-oxohexyl dihydrogen phosphate
Fructose-6-Phosphate (closed form)
D-mannose 6-phosphate
D-mannose 6-phosphate, also known as mannose-6-phosphate disodium salt, is a member of the class of compounds known as hexose phosphates. Hexose phosphates are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. D-mannose 6-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). D-mannose 6-phosphate can be found in a number of food items such as bog bilberry, wild celery, common pea, and breadnut tree seed, which makes D-mannose 6-phosphate a potential biomarker for the consumption of these food products. D-mannose 6-phosphate may be a unique S.cerevisiae (yeast) metabolite. The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate. The pH in the late endosome can reach 6.0, which causes dissociation of M6P from its receptor. Upon release, the enzymes are ferried to their final destination in the lysosomes. The MPRs are packed into vesicles that bud off the late endosome and return to the "trans"-Golgi network. In this way, the MPRs can be recycled . D-mannose 6-phosphate, also known as mannose-6-phosphate disodium salt, is a member of the class of compounds known as hexose phosphates. Hexose phosphates are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. D-mannose 6-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). D-mannose 6-phosphate can be found in a number of food items such as bog bilberry, wild celery, common pea, and breadnut tree seed, which makes D-mannose 6-phosphate a potential biomarker for the consumption of these food products. D-mannose 6-phosphate may be a unique S.cerevisiae (yeast) metabolite. The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate. The pH in the late endosome can reach 6.0, which causes dissociation of M6P from its receptor. Upon release, the enzymes are ferried to their final destination in the lysosomes. The MPRs are packed into vesicles that bud off the late endosome and return to the "trans"-Golgi network. In this way, the MPRs can be recycled.
Glucose 1-phosphate
COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
D-fructofuranose 6-phosphate
The five-membered ring form of D-fructose 6-phosphate.
D-Glucose 6-phosphate
The open-chain form of D-glucose 6-phosphate.
alpha-D-(+)-mannose-1-phosphate sodium salt hydrate
alpha-D-glucose-1-phosphate dipotassium salt dihydate
alpha-D-Glucose 1-phosphate
A D-glucopyranose 1-phosphate in which the anomeric centre has alpha-configuration.
1D-myo-inositol 6-phosphate
A myo-inositol monophosphate in which the phosphate group is located at position 6.
alpha-D-tagatofuranose 6-phosphate
A D-tagatofuranose 6-phosphate with an alpha-configuration at the anomeric position.
D-Mannose 1-phosphate
A mannose phosphate that is D-mannose carrying a phosphate group at position 1.
α-D-Glucose 1-phosphate
Alpha-d-glucose-1-phosphate, also known as D-glucose 1-phosphoric acid or alpha-D-glucopyranosyl phosphate, is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. Alpha-d-glucose-1-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). Alpha-d-glucose-1-phosphate can be found in a number of food items such as guava, purple mangosteen, cocoa bean, and fig, which makes alpha-d-glucose-1-phosphate a potential biomarker for the consumption of these food products. Alpha-d-glucose-1-phosphate exists in E.coli (prokaryote) and yeast (eukaryote).
(2,3,5,6-Tetrahydroxy-4-oxohexyl) dihydrogen phosphate
[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
keto-L-tagatose 6-phosphate
The open chain form of L-tagatose 6-phosphate
[(2S,3S,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl] dihydrogen phosphate
[(2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl] dihydrogen phosphate
[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
[(2S,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
[(3R,4R,5R)-2,4,5-trihydroxy-3-(hydroxymethyl)oxan-3-yl] dihydrogen phosphate
[(2S,3S,4R,5S)-3,4,5-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl dihydrogen phosphate
[(2R,3S,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
[(2S,3S,4R,5S)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
[(2S,3S,4S,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl dihydrogen phosphate
[(2R,3S,4R,5S)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
[(2R,3S,4S,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl dihydrogen phosphate
[(3S,4S,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl dihydrogen phosphate
[(3S,4R,5S)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
D-Allose 6-phosphate
An allose phosphate consisting of D-allose having a monophosphate group at the 6-position.
alpha-L-galactose 1-phosphate
A L-galactose 1-phosphate compound having beta-configuration about the anomeric centre.
[(2S,3S,4S,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
[(3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl dihydrogen phosphate
alpha-D-Glucose-1-phosphate
beta-D-Glucose 6-phosphate
A D-glucopyranose 6-phosphate in which the anomeric centre has beta-configuration.
alpha-D-Mannose 1-phosphate
A D-mannose 1-phosphate with an alpha-configuration at the anomeric position.
D-fructofuranose 1-phosphate
The furanose form of D-fructose 1-phosphate.
D-galactopyranose 6-phosphate
The pyranose form of D-galactose 6-phosphate.
D-Galactopyranose 1-phosphate
A D-galactose phosphate that consists of D-galactopyranose having a single phospho substituent located at the 1-position. It is an intermediate obtained during the the galactose metabolism.
beta-D-mannose 6-phosphate
A D-mannopyranose 6-phosphate with a beta-configuration at the anomeric position.
keto-D-fructose 1-phosphate
The open chain form of D-fructose 1-phosphate.
beta-D-fructofuranose 1-phosphate
A D-fructofuranose 1-phosphate in which the anomeric centre has beta-configuration.
D-mannitol 1-phosphate(2-)
An organophosphate oxoanion arising from deprotonation of the phosphate OH groups of D-mannitol.
D-glucitol 6-phosphate(2-)
Dianion of D-glucitol 1-phosphate arising from deprotonation of the phosphate OH groups; major species at pH 7.3.
beta-D-tagatofuranose 6-phosphate
A D-tagatofuranose 6-phosphate with a beta-configuration at the anomeric position.
6-O-phosphono-beta-D-galactofuranose
A D-galactose 6-phosphate that is beta-D-galactofuranose in which the hydroxy group at position 6 has been converted into the corresponding dihydrogen phosphate derivative.
aldehydo-D-galactose 6-phosphate
The ring-opened aldehydo-form of D-galactose 6-phosphate.
1D-myo-Inositol 1-phosphate
An inositol having myo- configuration substituted at position 1 by a phosphate group.
keto-D-tagatose 6-phosphate
A D-tagatose 6-phosphate that is in the open-chain keto-form.
Galactitol 1-phosphate(2-)
Dianion of D-galactitol 1-phosphate arising from deprotonation of the phosphate OH groups; major species at pH 7.3.
D-glucopyranose 6-phosphate
A glucopyranose ring with a phosphate replacing the hydroxy in the hydroxymethyl group at position 6.
keto-D-fructose 6-phosphate
The open chain form of D-fructose 6-phosphate.
D-Glucopyranose 1-phosphate
A D-glucose monophosphate in which the phosphate group is located at position 1.
beta-D-fructofuranose 6-phosphate
A D-fructofuranose 6-phosphate with a beta-configuration at the anomeric position.
D-tagatofuranose 6-phosphate
The furanose form of D-tagatose 6-phosphate.