N-acetyl Leukotriene E4 (BioDeep_00000181218)
human metabolite blood metabolite
代谢物信息卡片
化学式: C25H39NO6S (481.24979540000004)
中文名称:
谱图信息:
最多检出来源 Danio rerio(blood) 50%
分子结构信息
SMILES: CCCCCC=CCC=CC=CC=CC(SCC(NC(C)=O)C(O)=O)C(O)CCCC(O)=O
InChI: InChI=1S/C25H39NO6S/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-23(22(28)16-15-18-24(29)30)33-19-21(25(31)32)26-20(2)27/h7-8,10-14,17,21-23,28H,3-6,9,15-16,18-19H2,1-2H3,(H,26,27)(H,29,30)(H,31,32)
描述信息
同义名列表
9 个代谢物同义名
6-({2-carboxy-2-[(1-hydroxyethylidene)amino]ethyl}sulphanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid; 6-({2-carboxy-2-[(1-hydroxyethylidene)amino]ethyl}sulphanyl)-5-hydroxyicosa-7,9,11,14-tetraenoate; 6-({2-carboxy-2-[(1-hydroxyethylidene)amino]ethyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoate; 6-[(2-carboxy-2-acetamidoethyl)sulfanyl]-5-hydroxyicosa-7,9,11,14-tetraenoic acid; 5-Hydroxy-6-S-(2-acetamido-3-thiopropionyl)-7,9,11,14-eicosatetraenoic acid; N-acetyl Leukotriene E4; N-acetylleukotriene E4; N-Acetyl-lte(4); NA-lte4
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masahito Uemura, Hideyuki Kojima, Ulrike Buchholz, Eiryo Kikuchi, Masami Matsumoto, Masaji Kikukawa, Hiroo Imazu, Hiroshi Fukui, Tadasu Tsujii, Dietrich Keppler. Cysteinyl leukotrienes in the bile of patients with obstructive jaundice.
Journal of gastroenterology.
2002; 37(10):821-30. doi:
10.1007/s005350200136. [PMID: 12424566] - M Kodani, N Sakata, Y Takano, H Kamiya, T Katsuragi, T E Hugli, M Abe. Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes.
Immunopharmacology.
2000 Sep; 49(3):263-74. doi:
10.1016/s0162-3109(00)00240-x. [PMID: 10996024] - D W Butterly, R F Spurney, P Ruiz, R Griffiths, C Albrightson, T M Coffman. A role for leukotrienes in cyclosporine nephrotoxicity.
Kidney international.
2000 Jun; 57(6):2586-93. doi:
10.1046/j.1523-1755.2000.00118.x. [PMID: 10844628] - M Uemura, W D Lehmann, W Schneider, H K Seitz, A Benner, A Keppler-Hafkemeyer, P Hafkemeyer, H Kojima, M Fujimoto, T Tsujii, H Fukui, D Keppler. Enhanced urinary excretion of cysteinyl leukotrienes in patients with acute alcohol intoxication.
Gastroenterology.
2000 Jun; 118(6):1140-8. doi:
10.1016/s0016-5085(00)70367-2. [PMID: 10833489] - S Geuenich, C Haberl, D Egger, U Kaspers, L Hültner, W Wilmanns, C Denzlinger. Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo.
Biochemical pharmacology.
1998 Feb; 55(4):447-53. doi:
10.1016/s0006-2952(97)00481-4. [PMID: 9514079] - A Guhlmann, K Krauss, F Oberdorfer, T Siegel, P H Scheuber, J Müller, B Csuk-Glänzer, S Ziegler, H Ostertag, D Keppler. Noninvasive assessment of hepatobiliary and renal elimination of cysteinyl leukotrienes by positron emission tomography.
Hepatology (Baltimore, Md.).
1995 Jun; 21(6):1568-75. doi:
. [PMID: 7768501] - M Uemura, U Buchholz, H Kojima, A Keppler, P Hafkemeyer, H Fukui, T Tsujii, D Keppler. Cysteinyl leukotrienes in the urine of patients with liver diseases.
Hepatology (Baltimore, Md.).
1994 Oct; 20(4 Pt 1):804-12. doi:
10.1002/hep.1840200406. [PMID: 7927219] - C Denzlinger, W Tetzloff, H H Gerhartz, R Pokorny, S Sagebiel, C Haberl, W Wilmanns. Differential activation of the endogenous leukotriene biosynthesis by two different preparations of granulocyte-macrophage colony-stimulating factor in healthy volunteers.
Blood.
1993 Apr; 81(8):2007-13. doi:
. [PMID: 8386025] - H Jaeschke, M J Raftery, U Justesen, S J Gaskell. Serum complement mediates endotoxin-induced cysteinyl leukotriene formation in rats in vivo.
The American journal of physiology.
1992 Dec; 263(6 Pt 1):G947-52. doi:
10.1152/ajpgi.1992.263.6.g947. [PMID: 1476201] - D Keppler, M Müller, C Klünemann, A Guhlmann, K Krauss, J Müller, U Berger, I Leier, E Mayatepek. Transport and in vivo elimination of cysteinyl leukotrienes.
Advances in enzyme regulation.
1992; 32(?):107-16. doi:
10.1016/0065-2571(92)90011-n. [PMID: 1496913] - A L Siren, G Letts, G Feuerstein. N-acetyl-leukotriene E4 is a potent constrictor of rat mesenteric vessels.
European journal of pharmacology.
1988 Feb; 146(2-3):331-5. doi:
10.1016/0014-2999(88)90311-1. [PMID: 3371403] - L Orning. Omega-oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of omega-hydroxy and omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4.
European journal of biochemistry.
1987 Dec; 170(1-2):77-85. doi:
10.1111/j.1432-1033.1987.tb13669.x. [PMID: 2826163] - W Hagmann, A M Steffan, A Kirn, D Keppler. Leukotrienes as mediators in frog virus 3-induced hepatitis in rats.
Hepatology (Baltimore, Md.).
1987 Jul; 7(4):732-6. doi:
10.1002/hep.1840070419. [PMID: 3111968] - A Guhlmann, W Hagmann, D Keppler. Enterohepatic circulation of N-acetyl-leukotriene E4.
Prostaglandins.
1987 Jul; 34(1):63-70. doi:
10.1016/0090-6980(87)90263-2. [PMID: 3685398] - K Bernström, S Hammarström. Metabolism of leukotriene E4 by rat tissues: formation of N-acetyl leukotriene E4.
Archives of biochemistry and biophysics.
1986 Feb; 244(2):486-91. doi:
10.1016/0003-9861(86)90617-x. [PMID: 3004344] - L Orning, E Norin, B Gustafsson, S Hammarström. In vivo metabolism of leukotriene C4 in germ-free and conventional rats. Fecal excretion of N-acetylleukotriene E4.
The Journal of biological chemistry.
1986 Jan; 261(2):766-71. doi:
. [PMID: 3941100]