4-Aminoisoxazolidin-3-one (BioDeep_00000003879)

 

Secondary id: BioDeep_00000277584

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


(+-)-4-amino-3-isoxazolidinone

化学式: C3H6N2O2 (102.04292559999999)
中文名称: DL-环丝氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 7.27%

分子结构信息

SMILES: C1C(C(=O)NO1)N
InChI: InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)

描述信息

4-amino-1,2-oxazolidin-3-one is a member of the class of oxazolidines that is isoxazoldin-3-one which is substituted at position 4 by an amino group. It is a serine derivative, a member of oxazolidines, a primary amino compound and a hydroxamic acid ester.

同义名列表

6 个代谢物同义名

(+-)-4-amino-3-isoxazolidinone; 4-amino-1,2-oxazolidin-3-one; 4-Aminoisoxazolidin-3-one; DL-Cycloserine; Cycloserine; DL-Cycloserine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Wen-Xiao Tian, Shi Yu, Muhammad Ibrahim, Abdul Wareth Almonaofy, Liu He, Qiu Hui, Zhu Bo, Bin Li, Guan-Lin Xie. Copper as an antimicrobial agent against opportunistic pathogenic and multidrug resistant Enterobacter bacteria. Journal of microbiology (Seoul, Korea). 2012 Aug; 50(4):586-93. doi: 10.1007/s12275-012-2067-8. [PMID: 22923106]
  • Kari R Nations, Jasper A J Smits, David F Tolin, Barbara O Rothbaum, Stefan G Hofmann, Candyce D Tart, Allen Lee, Jacques Schipper, Magnus Sjogren, Dixi Xue, Armin Szegedi, Michael W Otto. Evaluation of the glycine transporter inhibitor Org 25935 as augmentation to cognitive-behavioral therapy for panic disorder: a multicenter, randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry. 2012 May; 73(5):647-53. doi: 10.4088/jcp.11m07081. [PMID: 22394471]
  • Laurent P Bogdanik, Harold D Chapman, Kathy E Miers, David V Serreze, Robert W Burgess. A MusD retrotransposon insertion in the mouse Slc6a5 gene causes alterations in neuromuscular junction maturation and behavioral phenotypes. PloS one. 2012; 7(1):e30217. doi: 10.1371/journal.pone.0030217. [PMID: 22272310]
  • Yves Briers, Titu Staubli, Markus C Schmid, Michael Wagner, Markus Schuppler, Martin J Loessner. Intracellular vesicles as reproduction elements in cell wall-deficient L-form bacteria. PloS one. 2012; 7(6):e38514. doi: 10.1371/journal.pone.0038514. [PMID: 22701656]
  • Wenqi Yu, Friedrich Götz. Cell wall antibiotics provoke accumulation of anchored mCherry in the cross wall of Staphylococcus aureus. PloS one. 2012; 7(1):e30076. doi: 10.1371/journal.pone.0030076. [PMID: 22253886]
  • V C C Cheng, W C Yam, O T C Lam, J L Y Tsang, E Y F Tse, G K H Siu, J F W Chan, H Tse, K K W To, J W M Tai, P L Ho, K Y Yuen. Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2011 Nov; 30(11):1371-81. doi: 10.1007/s10096-011-1231-0. [PMID: 21468685]
  • John H Krystal, Ismene L Petrakis, Diana Limoncelli, Susan Krasnicki Nappi, Louis Trevisan, Brian Pittman, Deepak C D'Souza, Raymond F Suckow. Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011 Feb; 36(3):701-10. doi: 10.1038/npp.2010.203. [PMID: 21124304]
  • Izabela Sitkiewicz, Ireneusz Babiak, Waleria Hryniewicz. Characterization of transcription within sdr region of Staphylococcus aureus. Antonie van Leeuwenhoek. 2011 Feb; 99(2):409-16. doi: 10.1007/s10482-010-9476-7. [PMID: 20571861]
  • Elizabeth A Mazzio, Fran Close, Karam F A Soliman. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences. 2011 Jan; 12(1):506-69. doi: 10.3390/ijms12010506. [PMID: 21340000]
  • Fabiana da Silva Alves, Erik Boot, Nicole Schmitz, Aart Nederveen, Jacob Vorstman, Christina Lavini, Petra J Pouwels, Petra Pouwels, Lieuwe de Haan, Don Linszen, Therese van Amelsvoort. Proton magnetic resonance spectroscopy in 22q11 deletion syndrome. PloS one. 2011; 6(6):e21685. doi: 10.1371/journal.pone.0021685. [PMID: 21738766]
  • Tina B Lonsdorf, Christian Rück, Jan Bergström, Gerhard Andersson, Arne Ohman, Nils Lindefors, Martin Schalling. The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder. BMC psychiatry. 2010 Nov; 10(?):99. doi: 10.1186/1471-244x-10-99. [PMID: 21110842]
  • Shigeto Yamamoto, Shigeru Morinobu, Yasuyuki Iwamoto, Yuto Ueda, Shiro Takei, Yosuke Fujita, Shigeto Yamawaki. Alterations in the hippocampal glycinergic system in an animal model of posttraumatic stress disorder. Journal of psychiatric research. 2010 Nov; 44(15):1069-74. doi: 10.1016/j.jpsychires.2010.03.013. [PMID: 20427053]
  • Elizabeth J Santa Ana, Bruce J Rounsaville, Tami L Frankforter, Charla Nich, Theresa Babuscio, James Poling, Kishorchandra Gonsai, Kevin P Hill, Kathleen M Carroll. D-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: a pilot investigation. Drug and alcohol dependence. 2009 Oct; 104(3):220-7. doi: 10.1016/j.drugalcdep.2009.04.023. [PMID: 19592176]
  • Haihua Feng, Hua Xiang, Jiyu Zhang, Guowen Liu, Na Guo, Xuelin Wang, Xiuping Wu, Xuming Deng, Lu Yu. Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cryptotanshinone. Journal of biomedicine & biotechnology. 2009; 2009(?):617509. doi: 10.1155/2009/617509. [PMID: 19707532]
  • Peter Sass, Andrea Jansen, Christiane Szekat, Vera Sass, Hans-Georg Sahl, Gabriele Bierbaum. The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus. BMC microbiology. 2008 Oct; 8(?):186. doi: 10.1186/1471-2180-8-186. [PMID: 18947397]
  • Seong S Shim, Michael D Hammonds, Baik S Kee. Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site. European archives of psychiatry and clinical neuroscience. 2008 Feb; 258(1):16-27. doi: 10.1007/s00406-007-0757-8. [PMID: 17901997]
  • Louis Trevisan, Ismene L Petrakis, Brian Pittman, Ralitza Gueorguieva, D Cyril D'Souza, Edward Perry, Diana Limoncelli, John H Krystal. Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors. Alcoholism, clinical and experimental research. 2008 Jan; 32(1):36-42. doi: 10.1111/j.1530-0277.2007.00543.x. [PMID: 18028532]
  • Teresa Musumeci, Cinzia Anna Ventura, Ignazio Giannone, Rosario Pignatello, Giovanni Puglisi. Development of a liposome formulation for D-cycloserine local delivery. Journal of liposome research. 2008; 18(3):211-24. doi: 10.1080/08982100802354624. [PMID: 18726817]
  • Hsien-Yuan Lane, Chieh-Liang Huang, Po-Lun Wu, Yi-Ching Liu, Yue-Cune Chang, Pao-Yen Lin, Po-Wei Chen, Guochuan Tsai. Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia. Biological psychiatry. 2006 Sep; 60(6):645-9. doi: 10.1016/j.biopsych.2006.04.005. [PMID: 16780811]
  • Steffen P Luntz, Kristina Unnebrink, Monika Seibert-Grafe, Hartwig Bunzendahl, Thomas W Kraus, Markus W Büchler, Ernst Klar, Peter Schemmer. HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312]. BMC surgery. 2005 Aug; 5(?):18. doi: 10.1186/1471-2482-5-18. [PMID: 16105183]
  • Donald C Goff, Lawrence Herz, Thomas Posever, Vivian Shih, Guochuan Tsai, David C Henderson, Oliver Freudenreich, A Eden Evins, Iftah Yovel, Hui Zhang, David Schoenfeld. A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients. Psychopharmacology. 2005 Apr; 179(1):144-50. doi: 10.1007/s00213-004-2032-2. [PMID: 15502972]
  • Guochuan Tsai, Hsien-Yuan Lane, Pinchen Yang, Mian-Yoon Chong, Nicholas Lange. Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biological psychiatry. 2004 Mar; 55(5):452-6. doi: 10.1016/j.biopsych.2003.09.012. [PMID: 15023571]
  • Nami Katayama, Hiroyoshi Takano, Motoji Sugiyama, Susumu Takio, Atsushi Sakai, Kan Tanaka, Haruko Kuroiwa, Kanji Ono. Effects of antibiotics that inhibit the bacterial peptidoglycan synthesis pathway on moss chloroplast division. Plant & cell physiology. 2003 Jul; 44(7):776-81. doi: 10.1093/pcp/pcg096. [PMID: 12881507]
  • Tara L Anderson, Alistair McGregor. Evaluation of the Clearview Clostridium difficile Toxin A Test and various selective culture media in comparison with the cytotoxin assay for the diagnosis of Clostridium difficile-associated diarrhoea. Pathology. 2003 Jun; 35(3):244-7. doi: 10.1080/0031302031000123236. [PMID: 14506970]
  • A Eden Evins, Ed Amico, Thomas A Posever, Rob Toker, Donald C Goff. D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia. Schizophrenia research. 2002 Jul; 56(1-2):19-23. doi: 10.1016/s0920-9964(01)00220-1. [PMID: 12084415]
  • R D Holbert, J E Pearson, F M Gonzalez. Effect of sodium acetate infusion on renal function in the dog. Archives internationales de pharmacodynamie et de therapie. 1976 Feb; 219(2):211-22. doi: NULL. [PMID: 5975]
  • M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1975 Sep; 71(6):609-29. doi: NULL. [PMID: 281]