S-DNP-Glutathione (BioDeep_00000181821)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H19N5O10S (473.0853)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
InChI: InChI=1S/C16H19N5O10S/c17-9(16(26)27)2-4-13(22)19-10(15(25)18-6-14(23)24)7-32-12-3-1-8(20(28)29)5-11(12)21(30)31/h1,3,5,9-10H,2,4,6-7,17H2,(H,18,25)(H,19,22)(H,23,24)(H,26,27)
描述信息
同义名列表
6 个代谢物同义名
2-Amino-4-({1-[(carboxymethyl)-C-hydroxycarbonimidoyl]-2-[(2,4-dinitrophenyl)sulphanyl]ethyl}-C-hydroxycarbonimidoyl)butanoic acid; 2-Amino-4-({1-[(carboxymethyl)-C-hydroxycarbonimidoyl]-2-[(2,4-dinitrophenyl)sulphanyl]ethyl}-C-hydroxycarbonimidoyl)butanoate; 2-Amino-4-({1-[(carboxymethyl)-C-hydroxycarbonimidoyl]-2-[(2,4-dinitrophenyl)sulfanyl]ethyl}-C-hydroxycarbonimidoyl)butanoate; 2-amino-4-({1-[(carboxymethyl)carbamoyl]-2-[(2,4-dinitrophenyl)sulfanyl]ethyl}carbamoyl)butanoic acid; 2-amino-4-{[1-(carboxymethylcarbamoyl)-2-[(2,4-dinitrophenyl)sulfanyl]ethyl]carbamoyl}butanoic acid; S-DNP-Glutathione
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sonali Dubey, Prashant Misra, Sanjay Dwivedi, Sandipan Chatterjee, Sumit K Bag, Shrikant Mantri, Mehar H Asif, Arti Rai, Smita Kumar, Manju Shri, Preeti Tripathi, Rudra D Tripathi, Prabodh K Trivedi, Debasis Chakrabarty, Rakesh Tuli. Transcriptomic and metabolomic shifts in rice roots in response to Cr (VI) stress.
BMC genomics.
2010 Nov; 11(?):648. doi:
10.1186/1471-2164-11-648. [PMID: 21092124] - Tomoharu Yokooji, Nobuhiro Mori, Teruo Murakami. Modulated function of tissue efflux transporters under hyperbilirubinemia in rats.
European journal of pharmacology.
2010 Jun; 636(1-3):166-72. doi:
10.1016/j.ejphar.2010.03.042. [PMID: 20362568] - T Yokooji, M Kida, M Mori, H Akashi, N Mori, S Yoshihara, T Murakami. Interaction of Rhei Rhizoma extract with cytochrome P450 3A and efflux transporters in rats.
Die Pharmazie.
2010 May; 65(5):367-74. doi:
". [PMID: 20503931] - Katja Berginc, Simon Zakelj, Darko Ursic, Albin Kristl. Aged garlic extract stimulates p-glycoprotein and multidrug resistance associated protein 2 mediated effluxes.
Biological & pharmaceutical bulletin.
2009 Apr; 32(4):694-9. doi:
10.1248/bpb.32.694. [PMID: 19336907] - Tomoharu Yokooji, Teruo Murakami, Ryoko Yumoto, Junya Nagai, Mikihisa Takano. Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.
The Journal of pharmacy and pharmacology.
2007 Apr; 59(4):513-20. doi:
10.1211/jpp.59.4.0005. [PMID: 17430634] - Tomoharu Yokooji, Teruo Murakami, Ryoko Yumoto, Junya Nagai, Mikihisa Takano. Function of multidrug resistance-associated protein 2 in acute hepatic failure rats.
European journal of pharmacology.
2006 Sep; 546(1-3):152-60. doi:
10.1016/j.ejphar.2006.06.079. [PMID: 16899240] - Kumiko Ogawa, Ryoko Yumoto, Natsuki Hamada, Junya Nagai, Mikihisa Takano. Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes.
Epilepsy research.
2006 Sep; 71(1):76-87. doi:
10.1016/j.eplepsyres.2006.05.016. [PMID: 16806827] - Silvina S M Villanueva, María L Ruiz, Carol J Soroka, Shi-Ying Cai, Marcelo G Luquita, Adriana M Torres, Enrique J Sánchez Pozzi, José M Pellegrino, James L Boyer, Viviana A Catania, Aldo D Mottino. Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathione in bile duct-ligated rats.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Aug; 34(8):1301-9. doi:
10.1124/dmd.106.009415. [PMID: 16679389] - Tomoharu Yokooji, Teruo Murakami, Kumiko Ogawa, Ryoko Yumoto, Junya Nagai, Mikihisa Takano. Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats.
The Journal of pharmacy and pharmacology.
2005 May; 57(5):579-85. doi:
10.1211/0022357056019. [PMID: 15901347] - Masakazu Hirouchi, Hiroshi Suzuki, Yuichi Sugiyama. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.
Pharmaceutical research.
2005 Apr; 22(4):661-6. doi:
10.1007/s11095-005-2502-1. [PMID: 15846474] - Marcela A Gonzalez, Marcelo G Roma, Claudio A Bernal, Maria de Lujan Alvarez, Maráia C Carrillo. Biliary secretory function in rats chronically intoxicated with aluminum.
Toxicological sciences : an official journal of the Society of Toxicology.
2004 May; 79(1):189-95. doi:
10.1093/toxsci/kfh085. [PMID: 14976346] - Young-Joo Lee, Hiroyuki Kusuhara, Yuichi Sugiyama. Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier?.
Journal of pharmaceutical sciences.
2004 Jan; 93(1):99-107. doi:
10.1002/jps.10521. [PMID: 14648640] - Rajendra Sharma, Yusong Yang, Abha Sharma, Seema Dwivedi, Vsevolod L Popov, Paul J Boor, Sharad S Singhal, Sanjay Awasthi, Yogesh C Awasthi. Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells.
Investigative ophthalmology & visual science.
2003 Aug; 44(8):3438-49. doi:
10.1167/iovs.03-0051. [PMID: 12882793] - Jingsong Cao, Bruno Stieger, Peter J Meier, Mary Vore. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy.
American journal of physiology. Gastrointestinal and liver physiology.
2002 Sep; 283(3):G757-66. doi:
10.1152/ajpgi.00126.2002. [PMID: 12181192] - Aldo D Mottino, Jingsong Cao, Luis M Veggi, Fernando Crocenzi, Marcelo G Roma, Mary Vore. Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide-induced cholestasis.
Hepatology (Baltimore, Md.).
2002 Jun; 35(6):1409-19. doi:
10.1053/jhep.2002.33327. [PMID: 12029626] - Rémon A M H van Aubel, Pascal H E Smeets, Janny G P Peters, René J M Bindels, Frans G M Russel. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.
Journal of the American Society of Nephrology : JASN.
2002 Mar; 13(3):595-603. doi:
10.1681/asn.v133595. [PMID: 11856762] - Y Cui, J König, D Keppler. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2.
Molecular pharmacology.
2001 Nov; 60(5):934-43. doi:
10.1124/mol.60.5.934. [PMID: 11641421] - I Podgorski, A W Bull. Energy-dependent export of the 13-oxooctadecadienoic acid-glutathione conjugate from HT-29 cells and plasma membrane vesicles.
Biochimica et biophysica acta.
2001 Aug; 1533(1):55-65. doi:
10.1016/s1388-1981(01)00140-8. [PMID: 11514236] - M J Harris, M Kuwano, M Webb, P G Board. Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT).
The Journal of biological chemistry.
2001 Jun; 276(24):20876-81. doi:
10.1074/jbc.m010566200. [PMID: 11274200]
