Kaempferol (BioDeep_00000000279)

 

Secondary id: BioDeep_00000270591, BioDeep_00000290764

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

化学式: C15H10O6 (286.0477)
中文名称: 3,4',5,7-四羟基黄酮, 山奈酚
谱图信息: 最多检出来源 Homo sapiens(plant) 24.33%

Reviewed

Last reviewed on 2024-10-31.

Cite this Page

Kaempferol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/kaempferol (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000279). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O)c1ccc(cc1)O)O)O
InChI: InChI=1/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

描述信息

Kaempferol is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment. It has a role as an antibacterial agent, a plant metabolite, a human xenobiotic metabolite, a human urinary metabolite, a human blood serum metabolite and a geroprotector. It is a member of flavonols, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a kaempferol oxoanion.
Kaempferol is a natural product found in Lotus ucrainicus, Visnea mocanera, and other organisms with data available.
Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources. Kaempferol is a yellow crystalline solid with a melting point of 276-278 degree centigrade. It is slightly soluble in water, and well soluble in hot ethanol and diethyl ether.
Kaempferol is a metabolite found in or produced by Saccharomyces cerevisiae.
See also: Cannabis sativa subsp. indica top (part of); Tussilago farfara flower (part of).
Kaempferol, also known as rhamnolutein or c.i. 75640, belongs to the class of organic compounds known as flavonols. Flavonols are compounds that contain a flavone (2-phenyl-1-benzopyran-4-one) backbone carrying a hydroxyl group at the 3-position. Thus, kaempferol is considered to be a flavonoid molecule. A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4. Kaempferol is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Kaempferol exists in all eukaryotes, ranging from yeast to humans. Kaempferol is a bitter tasting compound. Kaempferol is found, on average, in the highest concentration within a few different foods, such as saffrons, capers, and cumins and in a lower concentration in lovages, endives, and cloves. Kaempferol has also been detected, but not quantified, in several different foods, such as shallots, pine nuts, feijoa, kombus, and chicory leaves. This could make kaempferol a potential biomarker for the consumption of these foods. Kaempferol is a potentially toxic compound.
Very widespread in the plant world, e.g. in Brassicaceae, Apocynaceae, Dilleniaceae, Ranunculaceae, Leguminosae, etc. Found especies in broccoli, capers, chives, kale, garden cress, fennel, lovage, dill weed and tarragon [CCD]
A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
CONFIDENCE standard compound; INTERNAL_ID 898; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3906; ORIGINAL_PRECURSOR_SCAN_NO 3905
CONFIDENCE standard compound; INTERNAL_ID 898; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3916; ORIGINAL_PRECURSOR_SCAN_NO 3915
CONFIDENCE standard compound; INTERNAL_ID 898; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3928; ORIGINAL_PRECURSOR_SCAN_NO 3927
CONFIDENCE standard compound; INTERNAL_ID 898; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4291; ORIGINAL_PRECURSOR_SCAN_NO 4290
CONFIDENCE standard compound; INTERNAL_ID 898; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3918; ORIGINAL_PRECURSOR_SCAN_NO 3917
CONFIDENCE standard compound; INTERNAL_ID 898; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3915; ORIGINAL_PRECURSOR_SCAN_NO 3914
Acquisition and generation of the data is financially supported in part by CREST/JST.
INTERNAL_ID 2358; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2358
CONFIDENCE standard compound; INTERNAL_ID 47
CONFIDENCE standard compound; ML_ID 45
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].

同义名列表

80 个代谢物同义名

3,4,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-5,7,4-Trihydroxyflavonol; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)- (9CI); Kaempferol, United States Pharmacopeia (USP) Reference Standard; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-; 4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-(4-hydroxyphenyl)-; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,5,7-trihydroxy-2-(4-hydroxyphenyl)-; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one #; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 2-(4-hydroxyphenyl)-3,5,7-tris(oxidanyl)chromen-4-one; Kaempferol, primary pharmaceutical reference standard; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one??; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 5-18-05-00251 (Beilstein Handbook Reference); KAEMPFEROL (CONSTITUENT OF GINKGO) [DSC]; Flavone, 3,4,5,7-tetrahydroxy- (7CI,8CI); 3,4,5,7-tetrahydroxy-Flavone (7CI,8CI); A91A6666-86C8-4B33-B3EF-F74CD3CD7F47; KAEMPFEROL (CONSTITUENT OF GINKGO); Kaempferol, >=90\\% (HPLC), powder; Kaempferol, analytical standard; Flavone, 3,4,5,7-tetrahydroxy-; 3,4’,5,7-Tetrahydroxyflavone; 3,5,7,4’-Tetrahydroxyflavone; 3,4,5,7-tetrahydroxyflavone; Flavone,4,5,7-tetrahydroxy-; 3,5,7,4-Tetrahydroxyflavone; Kaempferol, >=97.0\\% (HPLC); 5,7,4’-Trihydroxyflavonol; 3,5,7-Tetrahydroxyflavone; 5,7,4-Trihydroxyflavonol; 5,4-Trihydroxyflavonol; KAEMPFEROL [USP-RS]; Kempferol;Robigenin; KAEMPFEROL [INCI]; Prestwick2_001098; 3’-Deoxyquercetin; Prestwick0_001098; Prestwick3_001098; KAEMPFEROL [HSDB]; KAEMPFEROL [IARC]; Prestwick1_001098; KAEMPFEROL (IARC); 3-DEOXYQUERCETIN; KAEMPFEROL [MI]; Kaempferol,(S); Pelargidenolon; Oprea1_650954; Indigo Yellow; BPBio1_001294; MEGxp0_001283; Rhamnolutein; Pelargidenon; HSCI1_000027; Tox21_201165; ACon1_001867; Tox21_303363; Rhamnolutin; C.I. 75640; Populnetin; Nimbecetin; Kaempherol; Kaempferol; Trifolitin; Swartziol; AI3-36096; Kampcetin; kempferol; Robigenin; Kampferol; Kaemferol; Campherol; Kampherol; CCRIS 41; 4det; 3 4 5 7-tetrahydroxyflavone; Kaempferol



数据库引用编号

68 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

3407 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ANG, CDKN1A, CYP1A1, ESR1, HPGDS, MAPK1, PRKAA2, TP53
Peripheral membrane protein 4 ACHE, CYP1A1, CYP1B1, ESR1
Endoplasmic reticulum membrane 2 CYP1A1, CYP1B1
Nucleus 10 ACHE, ANG, CDKN1A, ESR1, JUND, MAPK1, MPO, PPARA, PRKAA2, TP53
cytosol 8 ANG, CDKN1A, ESR1, HPGDS, IL1B, MAPK1, PRKAA2, TP53
dendrite 1 PRKAA2
nuclear body 1 CDKN1A
centrosome 2 MAPK1, TP53
nucleoplasm 9 CDKN1A, ESR1, HPGDS, JUND, MAPK1, MPO, PPARA, PRKAA2, TP53
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 3 ACHE, ESR1, MGAM
Cytoplasmic side 1 ESR1
Synapse 2 ACHE, MAPK1
cell surface 2 ACHE, ICAM1
Golgi apparatus 4 ACHE, ESR1, MAPK1, PRKAA2
growth cone 1 ANG
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 2 ANG, PRKAA2
Cytoplasm, cytosol 1 IL1B
Lysosome 2 IL1B, MPO
plasma membrane 5 ACHE, ESR1, ICAM1, MAPK1, MGAM
Membrane 7 ACHE, CYP1B1, ESR1, ICAM1, MGAM, PRKAA2, TP53
apical plasma membrane 1 MGAM
axon 1 PRKAA2
caveola 1 MAPK1
extracellular exosome 4 ICAM1, MGAM, MMP9, MPO
endoplasmic reticulum 1 TP53
extracellular space 9 ACHE, ANG, CCL2, CXCL8, ICAM1, IL1B, IL4, MMP9, MPO
perinuclear region of cytoplasm 2 ACHE, CDKN1A
mitochondrion 4 CYP1A1, CYP1B1, MAPK1, TP53
protein-containing complex 3 CDKN1A, ESR1, TP53
intracellular membrane-bounded organelle 4 CYP1A1, CYP1B1, HPGDS, MPO
Microsome membrane 2 CYP1A1, CYP1B1
Single-pass type I membrane protein 1 ICAM1
Secreted 7 ACHE, ANG, CCL2, CXCL8, IL1B, IL4, MGAM
extracellular region 10 ACHE, ANG, CCL2, CXCL8, IL1B, IL4, MAPK1, MGAM, MMP9, MPO
Single-pass membrane protein 1 MGAM
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ACHE
transcription regulator complex 3 ESR1, JUND, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 MAPK1, TP53
external side of plasma membrane 1 ICAM1
Secreted, extracellular space, extracellular matrix 1 MMP9
actin cytoskeleton 1 ANG
nucleolus 3 ANG, CDKN1A, TP53
Early endosome 1 MAPK1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 ICAM1
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 2 ICAM1, MAPK1
spindle 1 MAPK1
basement membrane 2 ACHE, ANG
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 2 ICAM1, MMP9
secretory granule 2 IL1B, MPO
nuclear speck 1 PRKAA2
Late endosome 1 MAPK1
chromatin 4 ESR1, JUND, PPARA, TP53
mitotic spindle 1 MAPK1
Chromosome 1 ANG
cytoskeleton 1 MAPK1
Nucleus, nucleolus 1 ANG
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
Membrane, caveola 1 MAPK1
tertiary granule membrane 1 MGAM
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 ESR1
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 MAPK1
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 MAPK1, MMP9
endoplasmic reticulum lumen 1 MAPK1
nuclear matrix 1 TP53
transcription repressor complex 2 JUND, TP53
tertiary granule lumen 1 MMP9
endocytic vesicle 1 ANG
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 2 MAPK1, MPO
immunological synapse 1 ICAM1
phagocytic vesicle lumen 1 MPO
[Isoform 1]: Nucleus 2 ESR1, TP53
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 MGAM
nucleotide-activated protein kinase complex 1 PRKAA2
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
transcription factor AP-1 complex 1 JUND
angiogenin-PRI complex 1 ANG
PCNA-p21 complex 1 CDKN1A
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Yunzhou Pu, Yicun Han, Yiran Ouyang, Haoze Li, Ling Li, Xinnan Wu, Liu Yang, Jingdong Gao, Lei Zhang, Jing Zhou, Qing Ji, Qing Song. Kaempferol inhibits colorectal cancer metastasis through circ_0000345 mediated JMJD2C/β-catenin signalling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155261. doi: 10.1016/j.phymed.2023.155261. [PMID: 38493716]
  • Yves Iradukunda, Jing-Yan Kang, Xiao-Bo Zhao, Xiao-Kang Fu, Stanislas Nsanzamahoro, Wei Ha, Yan-Ping Shi. Triple Sensing Modes for Triggered β-Galactosidase Activity Assays Based on Kaempferol-Deduced Silicon Nanoparticles and Biological Imaging of MCF-7 Breast Cancer Cells. ACS applied bio materials. 2024 May; 7(5):3154-3163. doi: 10.1021/acsabm.4c00185. [PMID: 38695332]
  • Qiuxiang Chen, Juan Wang, Lihua Sun, Bayinsilema Ba, Difei Shen. Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking. Journal of cellular and molecular medicine. 2024 May; 28(10):e18331. doi: 10.1111/jcmm.18331. [PMID: 38780500]
  • Anna Balykina, Lidia Naida, Kürsat Kirkgöz, Viacheslav O Nikolaev, Ekaterina Fock, Michael Belyakov, Anastasiia Whaley, Andrei Whaley, Valentina Shpakova, Natalia Rukoyatkina, Stepan Gambaryan. Antiplatelet Effects of Flavonoid Aglycones Are Mediated by Activation of Cyclic Nucleotide-Dependent Protein Kinases. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094864. [PMID: 38732081]
  • Kexin Chang, Kuangshi Fan, Hua Zhang, Qiong Wu, Yonghong Zhang, Le Wang, Hongcen Chen, Jinjin Tong, Defeng Cui. Fuzhengjiedu San inhibits porcine reproductive and respiratory syndrome virus by activating the PI3K/AKT pathway. PloS one. 2024; 19(5):e0283728. doi: 10.1371/journal.pone.0283728. [PMID: 38709810]
  • Xu Lian, Kaidi Fan, Xuemei Qin, Yuetao Liu. Amalgamated Pharmacoinformatics Study to Investigate the Mechanism of Xiao Jianzhong Tang against Chronic Atrophic Gastritis. Current computer-aided drug design. 2023 Jul; ?(?):. doi: 10.2174/1573409919666230720141115. [PMID: 37475552]
  • Lu Yan, Min-Yue Jiang, Xin-Sheng Fan. Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients. Journal of ethnopharmacology. 2023 Jun; ?(?):116773. doi: 10.1016/j.jep.2023.116773. [PMID: 37308028]
  • Xiling Zhu, Yan Li, Xiaodong Wang, Yuanshe Huang, Jingxin Mao. Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification. Medicine. 2023 Apr; 102(17):e33360. doi: 10.1097/md.0000000000033360. [PMID: 37115092]
  • Yanhong Sun, Xiaoyan Duan, Fenghe Wang, Huixin Tan, Jiahuan Hu, Wanting Bai, Xinbo Wang, Baolian Wang, Jinping Hu. Inhibitory effects of flavonoids on glucose transporter 1 (GLUT1): From library screening to biological evaluation to structure-activity relationship. Toxicology. 2023 Mar; ?(?):153475. doi: 10.1016/j.tox.2023.153475. [PMID: 36870413]
  • Adeola Oluwatosin Adedara, Guilherme Wildner, Julia Sepel Loreto, Matheus Mulling Dos Santos, Amos Olalekan Abolaji, Nilda Vargas Barbosa. Kaempferol counteracts toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in D. melanogaster: An implication of its mitoprotective activity. Neurotoxicology. 2022 Dec; 95(?):23-34. doi: 10.1016/j.neuro.2022.12.008. [PMID: 36592898]
  • Argyrios Periferakis, Konstantinos Periferakis, Ioana Anca Badarau, Elena Madalina Petran, Delia Codruta Popa, Ana Caruntu, Raluca Simona Costache, Cristian Scheau, Constantin Caruntu, Daniel Octavian Costache. Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications. International journal of molecular sciences. 2022 Nov; 23(23):. doi: 10.3390/ijms232315054. [PMID: 36499380]
  • Kaiyang Liu, Xi Chen, Yue Ren, Chaoqun Liu, Anlei Yuan, Lulu Zheng, Beiyan Li, Yanling Zhang. Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation. Toxicology and applied pharmacology. 2022 11; 454(?):116251. doi: 10.1016/j.taap.2022.116251. [PMID: 36150480]
  • Ruyang Yu, Jia Zhong, Qilyu Zhou, Wei Ren, Zhongjie Liu, Yifei Bian. Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity. Chemico-biological interactions. 2022 Oct; 366(?):110135. doi: 10.1016/j.cbi.2022.110135. [PMID: 36049518]
  • Anand Kumar Sahu, Ashok Kumar Mishra. Photophysical Behavior of Plant Flavonols Galangin, Kaempferol, Quercetin, and Myricetin in Homogeneous Media and the DMPC Model Membrane: Unveiling the Influence of the B-Ring Hydroxylation of Flavonols. The journal of physical chemistry. B. 2022 04; 126(15):2863-2875. doi: 10.1021/acs.jpcb.2c00929. [PMID: 35404618]
  • Shiquan Chang, Xin Li, Yachun Zheng, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Guoqiang Qian, Guoping Zhao. Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4/NF-ĸB signaling pathway. Phytotherapy research : PTR. 2022 Apr; 36(4):1678-1691. doi: 10.1002/ptr.7396. [PMID: 35234314]
  • Antoine Berger, Scott Latimer, Lauren R Stutts, Eric Soubeyrand, Anna K Block, Gilles J Basset. Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism. Current opinion in plant biology. 2022 04; 66(?):102165. doi: 10.1016/j.pbi.2021.102165. [PMID: 35026487]
  • Xichuan Li, Ce Wang, Jinqian Chen, Xia Hu, Hao Zhang, Zhiying Li, Bei Lan, Wei Zhang, Yanjun Su, Chunze Zhang. Potential interactions among myricetin and dietary flavonols through the inhibition of human UDP-glucuronosyltransferase in vitro. Toxicology letters. 2022 Apr; 358(?):40-47. doi: 10.1016/j.toxlet.2022.01.007. [PMID: 35063619]
  • Tsung-Ming Yeh, Ching-Dong Chang, Shyh-Shyan Liu, Chi-I Chang, Wen-Ling Shih. Tea Seed Kaempferol Triglycoside Attenuates LPS-Induced Systemic Inflammation and Ameliorates Cognitive Impairments in a Mouse Model. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072055. [PMID: 35408453]
  • Xiaoyan Li, Imran Khan, Guoxin Huang, Yiyan Lu, Liping Wang, Yuanyuan Liu, Linlin Lu, W L Wendy Hsiao, Zhongqiu Liu. Kaempferol acts on bile acid signaling and gut microbiota to attenuate the tumor burden in ApcMin/+ mice. European journal of pharmacology. 2022 Mar; 918(?):174773. doi: 10.1016/j.ejphar.2022.174773. [PMID: 35065044]
  • Agata Walkowiak, Kacper Wnuk, Michał Cyrankiewicz, Bogumiła Kupcewicz. Discrimination of Adulterated Ginkgo Biloba Products Based on 2T2D Correlation Spectroscopy in UV-Vis Range. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020433. [PMID: 35056747]
  • Magdalena Kluska, Michał Juszczak, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak. Effect of Kaempferol and Its Glycoside Derivatives on Antioxidant Status of HL-60 Cells Treated with Etoposide. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020333. [PMID: 35056649]
  • Xiaolin Xiao, Qichao Hu, Xinyu Deng, Kaiyun Shi, Wenwen Zhang, Yinxiao Jiang, Xiao Ma, Jinhao Zeng, Xiaoyin Wang. Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases. Pharmacological research. 2022 01; 175(?):106005. doi: 10.1016/j.phrs.2021.106005. [PMID: 34843960]
  • Yifei Bian, Jiaqi Lei, Jia Zhong, Bo Wang, Yan Wan, Jinxin Li, Chaoyong Liao, Yang He, Zhongjie Liu, Koichi Ito, Bingkun Zhang. Kaempferol reduces obesity, prevents intestinal inflammation, and modulates gut microbiota in high-fat diet mice. The Journal of nutritional biochemistry. 2022 01; 99(?):108840. doi: 10.1016/j.jnutbio.2021.108840. [PMID: 34419569]
  • Wenling Tu, Yinjie Hong, Miaoan Huang, Meimei Chen, Huijuan Gan. Effect of kaempferol on hedgehog signaling pathway in rats with --chronic atrophic gastritis - Based on network pharmacological screening and experimental verification. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112451. doi: 10.1016/j.biopha.2021.112451. [PMID: 34839256]
  • Olha Mykhailenko, Vilma Petrikaite, Michal Korinek, Fang-Rong Chang, Mohamed El-Shazly, Chia-Hung Yen, Ivan Bezruk, Bing-Hung Chen, Chung-Fan Hsieh, Dmytro Lytkin, Liudas Ivanauskas, Victoriya Georgiyants, Tsong-Long Hwang. Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts. Molecules (Basel, Switzerland). 2021 Dec; 27(1):. doi: 10.3390/molecules27010010. [PMID: 35011243]
  • Huihao Tang, Lili Yang, Longlong Wu, Huimin Wang, Kaixian Chen, Huali Wu, Yiming Li. Kaempferol, the melanogenic component of Sanguisorba officinalis, enhances dendricity and melanosome maturation/transport in melanocytes. Journal of pharmacological sciences. 2021 Dec; 147(4):348-357. doi: 10.1016/j.jphs.2021.08.009. [PMID: 34663517]
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