Classification Term: 167948
黄酮 (ontology term: acda6a380756e396614542fb020870ce)
黄酮
found 500 associated metabolites at sub_class metabolite taxonomy ontology rank level.
Ancestor: 黄酮类
Child Taxonomies: There is no child term of current ontology term.
Spinosin
Spinosin is a flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5 and 4, a methoxy group at position 7 and a 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 6 via a C-glycosidic linkage. It has a role as a plant metabolite and an anxiolytic drug. It is a flavone C-glycoside, a dihydroxyflavone and a monomethoxyflavone. It is functionally related to a flavone. Spinosin is a natural product found in Clutia abyssinica, Galipea trifoliata, and other organisms with data available. A flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5 and 4, a methoxy group at position 7 and a 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 6 via a C-glycosidic linkage. Spinosyn a C-glycoside flavonoid isolated from the seeds of Zizyphus jujube, with neuroprotective effects. Spinosin inhibits Aβ1-42 production and aggregation via activating Nrf2/HO-1 pathway[1][2][3]. Spinosyn a C-glycoside flavonoid isolated from the seeds of Zizyphus jujube, with neuroprotective effects. Spinosin inhibits Aβ1-42 production and aggregation via activating Nrf2/HO-1 pathway[1][2][3].
Isovitexin
Isovitexin is a C-glycosyl compound that consists of apigenin substituted by a 1,5-anhydro-D-glucitol moiety at position 6. It has a role as an EC 3.2.1.20 (alpha-glucosidase) inhibitor and a metabolite. It is a C-glycosyl compound and a trihydroxyflavone. It is functionally related to an apigenin. It is a conjugate acid of an isovitexin-7-olate. Isovitexin is a natural product found in Carex fraseriana, Rauhiella, and other organisms with data available. See also: Fenugreek seed (part of); Acai (part of); Crataegus monogyna flowering top (part of). [Raw Data] CBA25_Isovitexin_neg_20eV_1-7_01_1425.txt [Raw Data] CBA25_Isovitexin_neg_10eV_1-7_01_1369.txt [Raw Data] CBA25_Isovitexin_pos_30eV_1-7_01_1399.txt [Raw Data] CBA25_Isovitexin_neg_40eV_1-7_01_1427.txt [Raw Data] CBA25_Isovitexin_neg_30eV_1-7_01_1426.txt [Raw Data] CBA25_Isovitexin_neg_50eV_1-7_01_1428.txt [Raw Data] CBA25_Isovitexin_pos_20eV_1-7_01_1398.txt [Raw Data] CBA25_Isovitexin_pos_10eV_1-7_01_1358.txt [Raw Data] CBA25_Isovitexin_pos_40eV_1-7_01_1400.txt [Raw Data] CBA25_Isovitexin_pos_50eV_1-7_01_1401.txt Isovitexin is a flavonoid isolated from passion flower, Cannabis and, and the palm, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB. Isovitexin is a flavonoid isolated from passion flower, Cannabis and, and the palm, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB.
Isoorientin 7-O-(6'-O-(E)-feruloyl)glucoside
Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside, also known as homoorientin or luteolin-6-C-beta-D-glucoside, is a member of the class of compounds known as flavonoid c-glycosides. Flavonoid c-glycosides are compounds containing a carbohydrate moiety which is C-glycosidically linked to the 2-phenylchromen-4-one flavonoid backbone. Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside can be synthesized from luteolin. Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside is also a parent compound for other transformation products, including but not limited to, isoorientin 7-O-glucoside, 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin, and 7-O-(6-sinapoylglucosyl)isoorientin. Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside can be found in barley, which makes isoorientin 7-o-(6-o-(e)-feruloyl)glucoside a potential biomarker for the consumption of this food product. Acquisition and generation of the data is financially supported in part by CREST/JST. [Raw Data] CBA21_Isoorientin_neg_20eV_1-3_01_1409.txt [Raw Data] CBA21_Isoorientin_pos_20eV_1-3_01_1382.txt [Raw Data] CBA21_Isoorientin_pos_50eV_1-3_01_1385.txt [Raw Data] CBA21_Isoorientin_neg_40eV_1-3_01_1411.txt [Raw Data] CBA21_Isoorientin_neg_10eV_1-3_01_1365.txt [Raw Data] CBA21_Isoorientin_neg_50eV_1-3_01_1412.txt [Raw Data] CBA21_Isoorientin_pos_10eV_1-3_01_1354.txt [Raw Data] CBA21_Isoorientin_pos_40eV_1-3_01_1384.txt [Raw Data] CBA21_Isoorientin_pos_30eV_1-3_01_1383.txt [Raw Data] CBA21_Isoorientin_neg_30eV_1-3_01_1410.txt Isoorientin is a potent inhibitor of COX-2 with an IC50 value of 39 μM. Isoorientin is a potent inhibitor of COX-2 with an IC50 value of 39 μM.
Cosmosiin
Cosmosiin, also known as apigenin 7-O-glucoside or apigetrin, is a member of the class of compounds known as flavonoid-7-O-glycosides. Flavonoid-7-O-glycosides are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position. Cosmosiin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Cosmosiin can be found in a number of food items, such as common thyme, white lupine, common oregano, and orange mint. Cosmosiin can also be found in dandelion coffee and in Teucrium gnaphalodes (Wikipedia). Cosmosiin can also be found plants such as wild celery and anise. Cosmosiin has been shown to exhibit anti-platelet function (PMID: 21834233). Apigenin 7-O-beta-D-glucoside is a glycosyloxyflavone that is apigenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a non-steroidal anti-inflammatory drug, a metabolite and an antibacterial agent. It is a beta-D-glucoside, a dihydroxyflavone, a glycosyloxyflavone and a monosaccharide derivative. It is functionally related to an apigenin. It is a conjugate acid of an apigenin 7-O-beta-D-glucoside(1-). It is an enantiomer of an apigenin 7-O-beta-L-glucoside. Cosmosiin is a natural product found in Galeopsis tetrahit, Carex fraseriana, and other organisms with data available. See also: Chamomile (part of). Apiumetrin, also known as 7-O-beta-D-glucosyl-5,7,4-trihydroxyflavone or cosmosiin, is a member of the class of compounds known as flavonoid-7-o-glycosides. Flavonoid-7-o-glycosides are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position. Apiumetrin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Apiumetrin can be found in wild celery, which makes apiumetrin a potential biomarker for the consumption of this food product. Acquisition and generation of the data is financially supported in part by CREST/JST. Annotation level-1 Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS)[1][2]. Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS)[1][2].
Luteolin 7-glucoside
Luteolin 7-O-beta-D-glucoside is a glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and a plant metabolite. It is a beta-D-glucoside, a glycosyloxyflavone, a trihydroxyflavone and a monosaccharide derivative. It is functionally related to a luteolin. It is a conjugate acid of a luteolin 7-O-beta-D-glucoside(1-). Cynaroside is a natural product found in Verbascum lychnitis, Carex fraseriana, and other organisms with data available. See also: Cynara scolymus leaf (part of); Lonicera japonica flower (part of); Chamaemelum nobile flower (part of). Luteolin 7-glucoside is found in anise. Luteolin 7-glucoside is a constituent of the leaves of Capsicum annuum (red pepper).Cynaroside is a flavone, a flavonoid-like chemical compound. It is a 7-O-glucoside of luteolin and can be found in dandelion coffee, in Ferula varia and F. foetida in Campanula persicifolia and C. rotundifolia and in Cynara scolymus (artichoke) A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. Constituent of the leaves of Capsicum annuum (red pepper) Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities[1][3][4][5].
Eriodictyol
Eriodictyol, also known as 3,4,5,7-tetrahydroxyflavanone or 2,3-dihydroluteolin, belongs to the class of organic compounds known as flavanones. Flavanones are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3. Thus, eriodictyol is considered to be a flavonoid lipid molecule. Outside of the human body, eriodictyol has been detected, but not quantified in, several different foods, such as common oregano, common thymes, parsley, sweet basils, and tarragons. This could make eriodictyol a potential biomarker for the consumption of these foods. Eriodictyol is a compound isolated from Eriodictyon californicum and can be used in medicine as an expectorant. BioTransformer predicts that eriodictiol is a product of luteolin metabolism via a flavonoid-c-ring-reduction reaction catalyzed by an unspecified-gut microbiota enzyme (PMID: 30612223). Eriodictyol, also known as 5735-tetrahydroxyflavanone, is a member of the class of compounds known as flavanones. Flavanones are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3. Eriodictyol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Eriodictyol can be found in a number of food items such as rowal, grape, cardamom, and lemon balm, which makes eriodictyol a potential biomarker for the consumption of these food products. Eriodictyol is a bitter-masking flavanone, a flavonoid extracted from yerba santa (Eriodictyon californicum), a plant native to North America. Eriodictyol is one of the four flavanones identified in this plant as having taste-modifying properties, the other three being homoeriodictyol, its sodium salt, and sterubin . Eriodictyol is a tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3 and 4 respectively. It is a tetrahydroxyflavanone and a member of 3-hydroxyflavanones. Eriodictyol is a natural product found in Eupatorium album, Eupatorium hyssopifolium, and other organisms with data available. A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3 and 4 respectively. Acquisition and generation of the data is financially supported in part by CREST/JST. Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 18 nM. Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 18 nM.
Hamaudol 3-glucoside
C21H26O10 (438.15258960000006)
Sec-o-Glucosylhamaudol is a member of chromenes. sec-o-Glucosylhamaudol is a natural product found in Ostericum grosseserratum, Saposhnikovia divaricata, and other organisms with data available. Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect[1]. Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect[1]. Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect[1].
Spinosin B
6-Feruloylspinosin is a natural product found in Ziziphus spina-christi and Ziziphus jujuba with data available. Spinosin B is found in fruits. Spinosin B is isolated from Zizyphus jujuba (Chinese date). Isolated from Zizyphus jujuba (Chinese date). Spinosin B is found in fruits. 6'''-Feruloylspinosin is a flavonoid isolated from seeds of Ziziphus jujuba. 6'''-Feruloylspinosin can across the blood-brain barrier and enhance the expression of GABAAα1, GABAAα5, and GABABR1 mRNA in rat hippocampal neurons[1]. 6'''-Feruloylspinosin is a flavonoid isolated from seeds of Ziziphus jujuba. 6'''-Feruloylspinosin can across the blood-brain barrier and enhance the expression of GABAAα1, GABAAα5, and GABABR1 mRNA in rat hippocampal neurons[1]. 6'''-Feruloylspinosin is a flavonoid isolated from seeds of Ziziphus jujuba. 6'''-Feruloylspinosin can across the blood-brain barrier and enhance the expression of GABAAα1, GABAAα5, and GABABR1 mRNA in rat hippocampal neurons[1].
Morusinol
Morusinol is a member of flavones. Morusinol is a natural product found in Morus lhou, Morus mongolica, and other organisms with data available. Morusinol is found in fruits. Morusinol is isolated from root bark of Morus alba (white mulberry Morusinol is a flavonoid isolated from Morus alba root bark. Morusinol has an antiplatelet activity and ?significantly inhibits arterial thrombosis in vivo[1]. Morusinol is a flavonoid isolated from Morus alba root bark. Morusinol has an antiplatelet activity and ?significantly inhibits arterial thrombosis in vivo[1].
Swertisin
Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as a plant metabolite, an adenosine A1 receptor antagonist, an anti-inflammatory agent, an antioxidant and a hypoglycemic agent. It is a flavone C-glycoside, a monosaccharide derivative, a polyphenol, a monomethoxyflavone and a dihydroxyflavone. It is functionally related to an apigenin. Swertisin is a natural product found in Carex fraseriana, Gentiana orbicularis, and other organisms with data available. A flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. Swertisin, a C-glucosylflavone isolated from Iris tectorum, is known to have antidiabetic, anti-inflammatory and antioxidant effects. Swertisin is an adenosine A1 receptor antagonist[1][2].
Swertiajaponin
C22H22O11 (462.11620619999997)
Swertiajaponin is a natural product found in Carex fraseriana, Alliaria petiolata, and other organisms with data available. Swertiajaponin is found in green vegetables. Swertiajaponin is a constituent of leaves of Gnetum gnemon (bago)
Cirsilineol
Cirsilineol, also known as 4,5-dihydroxy-3,6,7-trimethoxy-flavone or anisomelin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, cirsilineol is considered to be a flavonoid lipid molecule. Cirsilineol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Cirsilineol can be found in a number of food items such as common thyme, tarragon, common sage, and hyssop, which makes cirsilineol a potential biomarker for the consumption of these food products. Cirsilineol is a bioactive flavone isolated from Artemisia and from Teucrium gnaphalodes . Cirsilineol is a trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7 and 3 and hydroxy groups at positions 5 and 4 respectively. It has a role as a plant metabolite and an antineoplastic agent. It is a trimethoxyflavone and a dihydroxyflavone. It is functionally related to a flavone. Cirsilineol is a natural product found in Thymus herba-barona, Salvia tomentosa, and other organisms with data available. See also: Tangerine peel (part of).
Neocarlinoside
Carlinoside is a C-glycosyl compound that is luteolin substituted at positions 8 and 6 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively. It has a role as a metabolite, an antioxidant and an anti-inflammatory agent. It is a tetrahydroxyflavone and a C-glycosyl compound. It is functionally related to a luteolin. Carlinoside is a natural product found in Passiflora sexflora, Glycine max, and other organisms with data available. Neocarlinoside is found in cereals and cereal products. Neocarlinoside is isolated from Oryza sativa (rice). Isolated from Oryza sativa (rice). Neocarlinoside is found in cereals and cereal products and rice.
6-Hydroxyluteolin 7-glucoside
C21H20O12 (464.09547200000003)
6-hydroxyluteolin 7-glucoside is a member of the class of compounds known as flavonoid-7-o-glycosides. Flavonoid-7-o-glycosides are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position. 6-hydroxyluteolin 7-glucoside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 6-hydroxyluteolin 7-glucoside can be found in german camomile, which makes 6-hydroxyluteolin 7-glucoside a potential biomarker for the consumption of this food product. 6-Hydroxyluteolin 7-glucoside is a natural product found in Globularia alypum, Halophila johnsonii, and other organisms with data available.
6-beta-D-Glucopyranosyl-8-beta-D-ribopyranosylapigenin
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-8-(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)-4H-chromen-4-one is a member of flavonoids and a C-glycosyl compound. 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-(3,4,5-trihydroxyoxan-2-yl)chromen-4-one is a natural product found in Cymbidium kanran, Acanthus, and other organisms with data available. 6-beta-D-Glucopyranosyl-8-beta-D-ribopyranosylapigenin is found in herbs and spices. 6-beta-D-Glucopyranosyl-8-beta-D-ribopyranosylapigenin is a constituent of Passiflora incarnata (maypops). Constituent of Passiflora incarnata (maypops). Apigenin 6-C-glucoside 8-C-riboside is found in herbs and spices. Neoschaftoside is a flavone C-glycoside that is apigenin attached to a beta-D-glucopyranosyl and a beta-L-arabinopyranosyl residues at positions 6 and 8 respectively via C-glycosidic linkage. It has a role as a plant metabolite. It is a flavone C-glycoside and a dihydroxyflavone. It is functionally related to an apigenin. Neoschaftoside is a natural product found in Radula complanata, Artemisia judaica, and other organisms with data available. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1]. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1]. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].
6'-Malonylcosmosiin
Apigenin 7-O-(6-malonyl-beta-D-glucoside) is a member of flavonoids and a glycoside. Apigenin 7-(6-malonylglucoside) is a natural product found in Monarda punctata and Cynara cardunculus with data available. 6-Malonylcosmosiin is found in herbs and spices. 6-Malonylcosmosiin is isolated from Petroselinum crispum (parsley). Isolated from Petroselinum crispum (parsley). 6-Malonylcosmosiin is found in herbs and spices. Apigenin 7-O-malonylglucoside is found in chrysanthemum flowers[1].
Cyclomorusin
Cyclomorusin A is an extended flavonoid that is cyclomulberrin in which the hydroxy group at position 10 has undergone oxidative cyclisation to position 3 of the 3-methylbut-2-en-1-yl substituent, with migration of the double bond into conjugation with the aromatic ring. It is a moderate inhibitor of acetylcholinesterase (IC50 = 16.2 - 36.6 muM), and a strong inhibitor of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) induced platelet aggregation. It has a role as a plant metabolite, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a platelet aggregation inhibitor and an EC 1.14.18.1 (tyrosinase) inhibitor. It is an extended flavonoid, an organic heteropentacyclic compound, a cyclic ketone and a polyphenol. It is functionally related to a cyclomulberrin. Cyclomorusin is a natural product found in Artocarpus altilis, Morus lhou, and other organisms with data available. An extended flavonoid that is cyclomulberrin in which the hydroxy group at position 10 has undergone oxidative cyclisation to position 3 of the 3-methylbut-2-en-1-yl substituent, with migration of the double bond into conjugation with the aromatic ring. It is a moderate inhibitor of acetylcholinesterase (IC50 = 16.2 - 36.6 muM), and a strong inhibitor of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) induced platelet aggregation. Isolated from the root bark of Morus alba (white mulberry)and is also from Artocarpus altilis (breadfruit). Cyclomorusin is found in breadfruit and fruits. Cyclomorusin is found in breadfruit. Cyclomorusin is isolated from the root bark of Morus alba (white mulberry). Also from Artocarpus altilis (breadfruit
Saponarin
7-O-(beta-D-glucosyl)isovitexin is a C-glycosyl compound that is isovitexin in which the hydroxyl hydrogen at position 7 is replaced by a beta-D-glucosyl residue. It has a role as a metabolite. It is a C-glycosyl compound, a dihydroxyflavone, a glycosyloxyflavone and a monosaccharide derivative. It is functionally related to an isovitexin. Saponarin is a natural product found in Hibiscus syriacus, Moraea sisyrinchium, and other organisms with data available. Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake[1][2][3]. Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake[1][2][3].
Meloside
Meloside, also known as isovitexin 2-beta-D-O-glucoside or 2-O-beta-D-glucosylisovitexin, is a member of the class of compounds known as flavonoid c-glycosides. Flavonoid c-glycosides are compounds containing a carbohydrate moiety which is C-glycosidically linked to the 2-phenylchromen-4-one flavonoid backbone. Meloside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Meloside can be found in muskmelon, which makes meloside a potential biomarker for the consumption of this food product. 2-O-(beta-D-glucosyl)isovitexin is a disaccharide derivative that is isovitexin substituted at position 2 on the glucose ring by a beta-D-glucosyl residue. It has a role as a metabolite. It is a C-glycosyl compound, a disaccharide derivative and a trihydroxyflavone. It is functionally related to an isovitexin. Meloside A is a natural product found in Ziziphus jujuba with data available. Meloside A (Isovitexin 2''-O-glucoside) is a phenylpropanoid isolated from barley with antioxidant activity. In barley, phenylpropanoids have been described as having protective properties against excess UV-B radiation and have been linked to resistance to pathogens[1][2].
Cirsimaritin
Cirsimaritin, also known as 4,5-dihydroxy-6,7-dimethoxyflavone or scrophulein, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, cirsimaritin is considered to be a flavonoid lipid molecule. Cirsimaritin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Cirsimaritin can be found in a number of food items such as italian oregano, lemon verbena, winter savory, and rosemary, which makes cirsimaritin a potential biomarker for the consumption of these food products.
Wogonin
Wogonin is a dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. It has a role as a cyclooxygenase 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is a conjugate acid of a wogonin(1-). Wogonin is a natural product found in Scutellaria likiangensis, Scutellaria amoena, and other organisms with data available. A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. Annotation level-1 Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects. Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.
Nobiletin
Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3 and 4 respectively. It has a role as a plant metabolite and an antineoplastic agent. It is functionally related to a flavone. Nobiletin is a natural product found in Citrus tankan, Citrus keraji, and other organisms with data available. See also: Tangerine peel (part of); Citrus aurantium fruit rind (part of). Isolated from peel of king orange (Citrus nobilis), seville orange (Citrus aurantium) and other Citrus subspecies, and the round kumquat (Fortunella japonica). Nobiletin is found in many foods, some of which are sweet bay, citrus, lemon, and grapefruit. Nobiletin is found in citrus. Nobiletin is isolated from peel of king orange (Citrus nobilis), seville orange (Citrus aurantium) and other Citrus species, and the round kumquat (Fortunella japonica A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3 and 4 respectively. D020011 - Protective Agents > D000975 - Antioxidants Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis[1][2][3][4]. Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis[1][2][3][4].
7-Hydroxyflavone
[Raw Data] CB049_7-Hydroxyflavone_pos_10eV_CB000023.txt [Raw Data] CB049_7-Hydroxyflavone_pos_30eV_CB000023.txt [Raw Data] CB049_7-Hydroxyflavone_pos_50eV_CB000023.txt [Raw Data] CB049_7-Hydroxyflavone_pos_20eV_CB000023.txt [Raw Data] CB049_7-Hydroxyflavone_pos_40eV_CB000023.txt [Raw Data] CB049_7-Hydroxyflavone_neg_20eV_000015.txt [Raw Data] CB049_7-Hydroxyflavone_neg_10eV_000015.txt [Raw Data] CB049_7-Hydroxyflavone_neg_40eV_000015.txt [Raw Data] CB049_7-Hydroxyflavone_neg_30eV_000015.txt [Raw Data] CB049_7-Hydroxyflavone_neg_50eV_000015.txt 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway[1][2]. 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway[1][2]. 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway[1][2].
Vitexin 2-rhamnoside
Acquisition and generation of the data is financially supported in part by CREST/JST. Vitexin-2"-O-rhamnoside, a main flavonoid glycoside of the leaves of Cratagus pinnatifida Bge, contributes to the protection against H2O2-mediated oxidative stress damage and has potential to treat cardiovascular system diseases[1]. Vitexin-2"-O-rhamnoside, a main flavonoid glycoside of the leaves of Cratagus pinnatifida Bge, contributes to the protection against H2O2-mediated oxidative stress damage and has potential to treat cardiovascular system diseases[1].
Tectochrysin
7-methylchrysin, also known as 5-hydroxy-7-methoxyflavone or techtochrysin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 7-methylchrysin is considered to be a flavonoid lipid molecule. 7-methylchrysin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 7-methylchrysin can be found in pine nut, prunus (cherry, plum), sour cherry, and sweet cherry, which makes 7-methylchrysin a potential biomarker for the consumption of these food products. relative retention time with respect to 9-anthracene Carboxylic Acid is 1.330 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.324 Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of NF-κB. Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of NF-κB.
(S)-scoulerine
C19H21NO4 (327.14705060000006)
(s)-scoulerine, also known as discretamine or aequaline, belongs to protoberberine alkaloids and derivatives class of compounds. Those are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton (s)-scoulerine is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). (s)-scoulerine can be found in a number of food items such as rice, lemon grass, chinese bayberry, and sea-buckthornberry, which makes (s)-scoulerine a potential biomarker for the consumption of these food products.
Luteolin 7-malonylglucoside
Luteolin 7-malonylglucoside, also known as luteolin 7-O-B-D-(6-O-malonyl) glucopyranoside, is a member of the class of compounds known as flavonoid-7-o-glycosides. Flavonoid-7-o-glycosides are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position. Luteolin 7-malonylglucoside is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Luteolin 7-malonylglucoside can be found in celery leaves, globe artichoke, and wild celery, which makes luteolin 7-malonylglucoside a potential biomarker for the consumption of these food products.
5,6,7,8,3,4,5-Heptamethoxyflavone
5,6,7-Trimethoxyflavone
5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera[1]. 5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera[1].
Morusin
Morusin is an extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2 and 4, a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8. It has a role as a plant metabolite and an antineoplastic agent. It is a trihydroxyflavone and an extended flavonoid. Morusin is a natural product found in Morus alba var. multicaulis, Broussonetia papyrifera, and other organisms with data available. An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2 and 4, a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8. Morusin is found in fruits. Morusin is a constituent of the root bark of Morus alba (mulberry) and other Morus species Constituent of the root bark of Morus alba (mulberry) and other Morus subspecies Morusin is found in fruits. Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity. Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.
Primetin
A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 5 and 8.
Majoranin
Majoranin, also known as 5,6,4-trihydroxy-7,8,3-trimethoxyflavone or mucroflavone b, is a member of the class of compounds known as 8-o-methylated flavonoids. 8-o-methylated flavonoids are flavonoids with methoxy groups attached to the C8 atom of the flavonoid backbone. Thus, majoranin is considered to be a flavonoid lipid molecule. Majoranin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Majoranin can be found in a number of food items such as peppermint, herbs and spices, mentha (mint), and fats and oils, which makes majoranin a potential biomarker for the consumption of these food products. Majoranin is found in common thyme. Majoranin is isolated from Majorana hortensis (sweet majoram), and Thymus vulgaris (thyme).
Phyllospadine
C21H21NO6 (383.13688060000004)
A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 7 and 4, a methoxy group at position 6 and a 1-methylpyrrolidin-2-yl group at position 8.
Isowertin 2'-rhamnoside
Isolated from Avena sativa (coats) and Gnetum africanum. Isoswertin 2-rhamnoside is found in oat, cereals and cereal products, and green vegetables. Isowertin 2-rhamnoside is found in cereals and cereal products. Isowertin 2-rhamnoside is isolated from Avena sativa (coats) and Gnetum africanum.
Agecorynin C
A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 2, 4 and 5.
Arcapillin
A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 2, 4 and 5 and methoxy groups at positions 5, 6 and 7 respectively.
Neocarlinoside
A flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5, 7, 3 and 4 and a beta-D-glucopyranosyl and a beta-L-arabinopyranosyl residue via C-glycosidic linkages at positions 6 and 8 respectively
Genkwanin
Genkwanin is a monomethoxyflavone that is apigenin in which the hydroxy group at position 7 is methylated. It has a role as a metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is functionally related to an apigenin. It is a conjugate acid of a genkwanin(1-). Genkwanin is a natural product found in Odontites viscosus, Eupatorium capillifolium, and other organisms with data available. A monomethoxyflavone that is apigenin in which the hydroxy group at position 7 is methylated. Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities. Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.
Alpha-Naphthoflavone
Alpha-naphthoflavone is an extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14). It has a role as an EC 1.14.14.14 (aromatase) inhibitor, an aryl hydrocarbon receptor antagonist and an aryl hydrocarbon receptor agonist. It is an organic heterotricyclic compound, an extended flavonoid and a naphtho-gamma-pyrone. alpha-Naphthoflavone is a natural product found in Rhaponticum repens with data available. D004791 - Enzyme Inhibitors > D001571 - Benzoflavones Alpha-Naphthoflavone is a flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively[1].
Mulberrin
Mulberrin is a natural product found in Morus alba var. multicaulis, Artocarpus fretessii, and other organisms with data available. Mulberrin is found in fruits. Mulberrin is a constituent of the root bark of Morus alba (white mulberry) Constituent of the root bark of Morus alba (white mulberry). Mulberrin is found in jackfruit and fruits. D000893 - Anti-Inflammatory Agents Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8?±1.5 μM. Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8?±1.5 μM.
Kuwanon A
Kuwanon A is a member of flavones. Kuwanon A is a natural product found in Morus alba var. multicaulis, Morus lhou, and Morus alba with data available. Kuwanon A is found in fruits. Kuwanon A is a constituent of the root bark of Morus alba (white mulberry) Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM. Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.
Nepitrin
Nepitrin is a member of flavonoids and a glycoside. Nepitrin is a natural product found in Centaurea bracteata, Arnica longifolia, and other organisms with data available. Nepitrin is found in herbs and spices. Nepitrin is a constituent of rosemary (Rosmarinus officinalis) Constituent of rosemary (Rosmarinus officinalis). Nepitrin is found in herbs and spices and rosemary. Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity[1][2]. Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity[1][2].
Kaempferol 3-(6'-rhamnosylsophoroside)
3-[4,5-Dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one is a natural product found in Camellia oleifera and Prunus avium with data available. Isolated from Solanum subspecies and soya beans. Astragalin 2-glucoside 6-rhamnoside is found in many foods, some of which are potato, soy bean, pulses, and oil-seed camellia. Camelliaside A is found in tea. Camelliaside A is isolated from China tea (Camellia sinensis) seeds. Camelliaside A is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace[1]. Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside is a natural glycoside that could be found in Camellia oleifera seeds[1].
Norartocarpetin
Norartocarpetin is a member of flavones. Norartocarpetin is a natural product found in Dalbergia sissoo, Ficus formosana, and other organisms with data available. Norartocarpetin is found in fruits. Norartocarpetin is a constituent of the heartwood of Artocarpus heterophyllus (jackfruit) Constituent of the heartwood of Artocarpus heterophyllus (jackfruit). Norartocarpetin is found in jackfruit and fruits. Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC50 value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC50 value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells[1][2]. Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC50 value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC50 value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells[1][2].
Albanin A
Albanin A is a member of flavones. Albanin A is a natural product found in Artocarpus gomezianus, Brosimum lactescens, and other organisms with data available. Albanin A is found in fruits. Albanin A is isolated from Morus alba (white mulberry) infected with Fusarium solani. Isolated from Morus alba (white mulberry) infected with Fusarium solani. Albanin A is found in fruits.
1,3,6-Trihydroxy-5-methoxyxanthone
1,3,6-Trihydroxy-5-methoxyxanthone is a member of xanthones. 1,3,6-Trihydroxy-5-methoxyxanthone is a natural product found in Hypericum chinense, Canscora alata, and other organisms with data available. 1,3,6-Trihydroxy-5-methoxyxanthone is found in fruits. 1,3,6-Trihydroxy-5-methoxyxanthone is a constituent of Garcinia dulcis (mundu). Constituent of Garcinia dulcis (mundu). 1,3,6-Trihydroxy-5-methoxyxanthone is found in fruits.
Isorhoifolin
Isorhoifolin is a natural product found in Astragalus onobrychis, Phillyrea latifolia, and other organisms with data available. Isorhoifolin is found in citrus. Isorhoifolin is isolated from leaves of Citrus paradisi (grapefruit) and other plant species. Isorhoifolin is a flavonoid glycoside from Hemistepta lyrata. Isorhoifolin displays an anti-leakage effect[1][2]. Isorhoifolin is a flavonoid glycoside from Hemistepta lyrata. Isorhoifolin displays an anti-leakage effect[1][2].
Neobaicalein
Scullcapflavone II is a tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6 and hydroxy groups at positons 5 and 2 respectively. It has a role as a plant metabolite and an anti-asthmatic drug. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a flavone. Skullcapflavone II is a natural product found in Lagochilus leiacanthus, Scutellaria guatemalensis, and other organisms with data available. A tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6 and hydroxy groups at positons 5 and 2 respectively. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
4',5,7-Trimethoxyflavone
4,5,7-Trimethoxyflavone, also known as trimethylapigenin, belongs to the class of organic compounds known as 7-O-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 4,5,7-trimethoxyflavone is considered to be a flavonoid lipid molecule. 4,5,7-Trimethoxyflavone is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, 4,5,7-trimethoxyflavone has been detected, but not quantified in, a few different foods, such as citrus, mandarin orange (clementine, tangerine), and sweet oranges. This could make 4,5,7-trimethoxyflavone a potential biomarker for the consumption of these foods. 4,5,7-Trimethoxyflavone is an ether and a member of flavonoids. 4,5,7-Trimethoxyflavone is a natural product found in Tanacetum vulgare, Citrus medica, and other organisms with data available. See also: Tangerine peel (part of). Occurs in the peel of Citrus reticulata (mandarin). 4,5,7-Trimethylapigenin is found in sweet orange and citrus. 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1]. 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1].
Luteolin 7-sulfate
C15H10O9S (366.00455300000004)
Luteolin 7-sulfate is a member of flavones. Luteolin 7-sulfate is a natural product found in Fuchsia perscandens, Fuchsia colensoi, and other organisms with data available. Luteolin 7-sulfate is isolated from Bixa orellana (annatto).
Tricetin Pentamethyl Ether
3,4,5,5,7-Pentamethoxyflavone is a natural product found in Ficus maxima, Ficus formosana, and other organisms with data available. 3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway[1]. 3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway[1].
Kuwanon B
Kuwanon B is a member of flavones. Kuwanon B is a natural product found in Morus alba with data available. Kuwanon B is found in fruits. Kuwanon B is a constituent of the root bark of Morus alba (white mulberry)
Luteolin 7-glucuronide
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively. Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.
Isoscoparin 2'-O-glucoside
Isoscoparin 2-O-glucoside is found in cereals and cereal products. Isoscoparin 2-O-glucoside is isolated from Oryza sativa (rice). Isolated from Oryza sativa (rice). Isoscoparin 2-glucoside is found in cereals and cereal products and rice.
Isoscoparin 2'-(6-(E)-ferulylglucoside)
Isoscoparin 2-(6-(E)-ferulylglucoside) is found in cereals and cereal products. Isoscoparin 2-(6-(E)-ferulylglucoside) is isolated from rice. Isolated from rice. Isoscoparin 2-(6-(E)-feruloylglucoside) is found in cereals and cereal products and rice.
Meloside L
Constituent of the leaves of melon (Cucumis melo) and rice (Oryza sativa). Isoorientin 2-glucoside is found in many foods, some of which are rice, cereals and cereal products, muskmelon, and fruits. Meloside L is found in cereals and cereal products. Meloside L is a constituent of the leaves of melon (Cucumis melo) and rice (Oryza sativa)
Sudachitin
Isolated from Citrus subspecies and peppermint Mentha piperita. Sudachitin is found in peppermint and citrus. Sudachitin is found in citrus. Sudachitin is isolated from Citrus species and peppermint Mentha piperita.
3,6-Diglucopyranosyl-4',5,7-trihydroxyflavone
3,6-Diglucopyranosyl-4,5,7-trihydroxyflavone is found in citrus. 3,6-Diglucopyranosyl-4,5,7-trihydroxyflavone is isolated from Citrus unshiu (satsuma mandarin). Isolated from Citrus unshiu (satsuma mandarin). Apigenin 3,6-di-C-glucoside is found in citrus.
7-Hydroxy-3',4',5,6-tetramethoxyflavone
7-Hydroxy-3,4,5,6-tetramethoxyflavone is found in citrus. 7-Hydroxy-3,4,5,6-tetramethoxyflavone is isolated from Citrus reticulata (manadarin orange). Isolated from Citrus reticulata (manadarin orange). 7-Hydroxy-3,4,5,6-tetramethoxyflavone is found in citrus.
5-Hydroxy-7-methoxy-6-methylflavone
5-Hydroxy-7-methoxy-6-methylflavone is found in tea. 5-Hydroxy-7-methoxy-6-methylflavone is isolated from Leptospermum scoparium (red tea). Isolated from Leptospermum scoparium (red tea). 5-Hydroxy-7-methoxy-6-methylflavone is found in tea.
Rubraflavone A
Rubraflavone A is found in fruits. Rubraflavone A is a constituent of Morus rubra (red mulberry)
Sudachiin A
Sudachiin A is found in citrus. Sudachiin A is isolated from Citrus sudachi peel. Isolated from Citrus sudachi peel. Sudachiin A is found in citrus.
Rubraflavone C
Rubraflavone C is found in fruits. Rubraflavone C is a constituent of Morus rubra (red mulberry)
Margaritene
Margaritene is found in fruits. Margaritene is isolated from Fortunella margarita (oval kumquat) and Fortunella japonica (round kumquat). Isolated from Fortunella margarita (oval kumquat) and Fortunella japonica (round kumquat). Margaritene is found in fruits.
4',5-Dihydroxy-7,8-dimethoxyflavone
4,5-Dihydroxy-7,8-dimethoxyflavone is found in citrus. 4,5-Dihydroxy-7,8-dimethoxyflavone is obtained from leaves and stems of Scutellaria species and from peel of Citrus reticulata (mandarin obtained from leaves and stems of Scutellaria subspecies and from peel of Citrus reticulata (mandarin). 7,8-Dimethylisoscutellarein is found in citrus.
2'-O-p-Coumaroylvitexin
2-O-p-Coumaroylvitexin is found in fenugreek. 2-O-p-Coumaroylvitexin is isolated from fenugreek seeds Trigonella foenum-graecum. Isolated from fenugreek seeds Trigonella foenum-graecum. 2-p-Coumaroylvitexin is found in herbs and spices and fenugreek.
Demethoxysudachitin
Demethoxysudachitin is found in citrus. Demethoxysudachitin is isolated from Citrus sudachi and Mentha piperit
3,6-Diglucopyranosyl-5,7-dihydroxy-4'-methoxyflavone
3,6-Diglucopyranosyl-5,7-dihydroxy-4-methoxyflavone is found in fruits. 3,6-Diglucopyranosyl-5,7-dihydroxy-4-methoxyflavone is isolated from Fortunella japonica (round kumquat). Isolated from Fortunella japonica (round kumquat). Acacetin 3,6-di-C-glucoside is found in fruits.
Integrin
Integrin is found in fruits. Integrin is a constituent of heartwood of Artocarpus integer (champeduk)
5-Hydroxy-4',7-dimethoxy-6-methylflavone
5-Hydroxy-4,7-dimethoxy-6-methylflavone is found in beverages. 5-Hydroxy-4,7-dimethoxy-6-methylflavone is isolated from Gaultheria procumbens (wintergreen). Isolated from Gaultheria procumbens (wintergreen). 5-Hydroxy-4,7-dimethoxy-6-methylflavone is found in tea, herbs and spices, and beverages.
Diosmetin 8-C-(2'-rhamnosylglucoside)
Diosmetin 8-C-(2-rhamnosylglucoside) is found in fruits. Diosmetin 8-C-(2-rhamnosylglucoside) is isolated from Fortunella japonica (round kumquat). Isolated from Fortunella japonica (round kumquat). Diosmetin 8-C-(2-rhamnosylglucoside) is found in fruits.
5-Hydroxy-4',7,8-trimethoxyflavone
5-Hydroxy-4,7,8-trimethoxyflavone is found in citrus. 5-Hydroxy-4,7,8-trimethoxyflavone is from the peel of Citrus reticulata (mandarin). From the peel of Citrus reticulata (mandarin). 7,8,4-Trimethylisoscutellarein is found in citrus.
Farnisin
Farnisin is a constituent of the seeds of Acacia farnesiana (sweet acacia)
6,8-Diglucosyldiosmetin
6,8-Diglucosyldiosmetin is found in citrus. 6,8-Diglucosyldiosmetin is isolated from peelings of Citrus limon (lemon). Isolated from peelings of Citrus limon (lemon). Diosmetin 6,8-di-C-glucoside is found in lemon and citrus.
Isoswertiajaponin
C22H22O11 (462.11620619999997)
Isoswertiajaponin is found in green vegetables. Isoswertiajaponin is isolated from Gnetum gnemon (bago). Isolated from Gnetum gnemon (bago). 7-Methoxy orientin is found in nuts and green vegetables.
Maysin 3'-methyl ether
Maysin 3-methyl ether is found in cereals and cereal products. Maysin 3-methyl ether is isolated from corn silk (Zea mays). Isolated from corn silk (Zea mays). Maysin 3-methyl ether is found in cereals and cereal products and corn.
2',3'-Diacetylcosmosiin
2,3-Diacetylcosmosiin is found in german camomile. 2,3-Diacetylcosmosiin is isolated from Matricaria chamomilla (German chamomile). Isolated from Matricaria chamomilla (German chamomile). 2,3-Diacetylcosmosiin is found in german camomile and herbs and spices.
Oxyisocyclointegrin
Oxyisocyclointegrin is found in fruits. Oxyisocyclointegrin is a constituent of heartwood of Artocarpus integer (champedak)
3',4',5'-Trimethoxyflavone
3,4,5-Trimethoxyflavone is found in herbs and spices. 3,4,5-Trimethoxyflavone is a constituent of the flowers of Primula veris (cowslip). Constituent of the flowers of Primula veris (cowslip). 3,4,5-Trimethoxyflavone is found in tea and herbs and spices.
Isomargaritene
Isomargaritene is found in fruits. Isomargaritene is isolated from Fortunella margarita (oval kumquat) and Fortunella japonica (round kumquat). Isolated from Fortunella margarita (oval kumquat) and Fortunella japonica (round kumquat). Isomargaritene is found in fruits.
Sideritiflavone
Isolated from Mentha piperita. Sideritiflavone is found in spearmint, peppermint, and herbs and spices. Sideritiflavone is found in herbs and spices. Sideritiflavone is isolated from Mentha piperita.
Apigenin 7-sulfate
C15H10O8S (350.00963800000005)
Apigenin 7-sulfate is isolated from Bixa orellana (annatto) Apigenin is a flavone that is the aglycone of several glycosides. It is a yellow crystalline solid that has been used to dye wool. Apigenin is a plant-derived flavonoid that has significant promise as a skin cancer chemopreventive agent. Apigenin inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, is increased by differentiating agents via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Apigenin suppresses the 12-O-tetradeconylphorbol-13-acetate-dependent increase in AP1 factor expression and binding to the hINV promoter and the increase in hINV promoter activity. Apigenin also inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. The suppression of PKCdelta activity is associated with reduced phosphorylation of PKCdelta-Y311. Activation of hINV promoter activity by the green tea polyphenol, (-)-epigellocathecin-3-gallate, is also inhibited by apigenin, suggesting that the two chemopreventive agents can produce opposing actions in keratinocytes. (PMID: 16982614); Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. This flavonoid provides selective activity to promote caspase-dependent-apoptosis of leukemia cells and uncover an essential role of PKCdelta during the induction of apoptosis by apigenin. (PMID: 16844095); Apigenin markedly induces the expression of death receptor 5 (DR5) and synergistically acts with exogenous soluble recombinant human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in malignant tumor cells. On the other hand, apigenin-mediated induction of DR5 expression is not observed in normal human peripheral blood mononuclear cells. Moreover, apigenin does not sensitize normal human peripheral blood mononuclear cells to TRAIL-induced apoptosis. (PMID: 16648565); Apigenin is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body. Isolated from Bixa orellana (annatto)
Takakin
Isolated from aerial parts of Citrus reticulata (mandarin). 4-Methylisoscutellarein is found in citrus. Takakin is found in citrus. Takakin is isolated from aerial parts of Citrus reticulata (mandarin
4',5-Dihydroxy-7-methoxy-6-methylflavone
4,5-Dihydroxy-7-methoxy-6-methylflavone is found in beverages. 4,5-Dihydroxy-7-methoxy-6-methylflavone is isolated from Gaultheria procumbens (wintergreen
Cyclointegrin
Cyclointegrin is found in fruits. Cyclointegrin is isolated from heartwood of Artocarpus integer (champedak
Luteolin 4'-sulfate
C15H10O9S (366.00455300000004)
Isolated from Daucus carota (carrot). Luteolin 4-sulfate is found in wild carrot, root vegetables, and carrot. Luteolin 4-sulfate is found in carrot. Luteolin 4-sulfate is isolated from Daucus carota (carrot).
Hymenoxin
Isolated from Mentha piperita (peppermint). Hymenoxin is found in sunflower, peppermint, and herbs and spices. Hymenoxin is found in herbs and spices. Hymenoxin is isolated from Mentha piperita (peppermint).
8-Hydroxyluteolin 8-glucoside 3'-sulfate
C21H20O15S (544.0522890000001)
8-Hydroxyluteolin 8-glucoside 3-sulfate is found in green vegetables. 8-Hydroxyluteolin 8-glucoside 3-sulfate is isolated from high mallow (Malva sylvestris).
Tricin 7-[rhamnosyl-(1->2)-galacturonide]
Tricin 7-[rhamnosyl-(1->2)-galacturonide] is isolated from sugar cane mill syrup (Saccharum species). Isolated from sugar cane mill syrup (Saccharum subspecies)
Vitexin 7-O-glucoside 2'-p-coumarate
Vitexin 7-O-glucoside 2-p-coumarate is found in cereals and cereal products. Vitexin 7-O-glucoside 2-p-coumarate is isolated from Mollugo oppositifolia (wheat). Isolated from Mollugo oppositifolia (wheat). Vitexin 7-glucoside 2-p-coumarate is found in cereals and cereal products.
Luteolin 7-glucoside 3'-glucuronide
Luteolin 7-glucoside 3-glucuronide is a member of the class of compounds known as flavonoid o-glucuronides. Flavonoid o-glucuronides are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to glucuronic acid. Thus, luteolin 7-glucoside 3-glucuronide is considered to be a flavonoid lipid molecule. Luteolin 7-glucoside 3-glucuronide is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Luteolin 7-glucoside 3-glucuronide can be found in lemon balm, which makes luteolin 7-glucoside 3-glucuronide a potential biomarker for the consumption of this food product.
Tetramethylisoscutellarein
Tetramethylisoscutellarein, also known as 5784-tetramethoxyflavone, is a member of the class of compounds known as 8-o-methylated flavonoids. 8-o-methylated flavonoids are flavonoids with methoxy groups attached to the C8 atom of the flavonoid backbone. Thus, tetramethylisoscutellarein is considered to be a flavonoid lipid molecule. Tetramethylisoscutellarein is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Tetramethylisoscutellarein can be found in sweet orange, which makes tetramethylisoscutellarein a potential biomarker for the consumption of this food product. 6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2]. 6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].
7-Demethyltangeretin
7-demethyltangeretin is a member of the class of compounds known as 8-o-methylated flavonoids. 8-o-methylated flavonoids are flavonoids with methoxy groups attached to the C8 atom of the flavonoid backbone. Thus, 7-demethyltangeretin is considered to be a flavonoid lipid molecule. 7-demethyltangeretin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 7-demethyltangeretin can be found in mandarin orange (clementine, tangerine), which makes 7-demethyltangeretin a potential biomarker for the consumption of this food product.
Luteolin 7-gentiobioside
Luteolin 7-gentiobioside is a member of the class of compounds known as flavonoid-7-o-glycosides. Flavonoid-7-o-glycosides are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position. Luteolin 7-gentiobioside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Luteolin 7-gentiobioside can be found in dandelion, which makes luteolin 7-gentiobioside a potential biomarker for the consumption of this food product.
Baicalein
Baicalein is a trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. It has a role as an antioxidant, a hormone antagonist, a prostaglandin antagonist, an EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, a radical scavenger, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an anti-inflammatory agent, a plant metabolite, a ferroptosis inhibitor, an anticoronaviral agent, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an angiogenesis inhibitor, an antineoplastic agent, an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antibacterial agent, an antifungal agent, an apoptosis inducer and a geroprotector. It is a conjugate acid of a baicalein(1-). Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ⅡA Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of Improve Other Aspects of Healthy Adult With Influenza Fever). Baicalein is a natural product found in Stachys annua, Stellera chamaejasme, and other organisms with data available. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. D020011 - Protective Agents > D000975 - Antioxidants COVID info from PDB, Protein Data Bank D004791 - Enzyme Inhibitors Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS Baicalein, also known as 5,6,7-trihydroxyflavone or baicalein (old), is a member of the class of compounds known as flavones. Flavones are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). Thus, baicalein is considered to be a flavonoid lipid molecule. Baicalein is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Baicalein can be found in welsh onion, which makes baicalein a potential biomarker for the consumption of this food product. Baicalein, along with its analogue baicalin, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors. In accordance, baicalein shows anxiolytic effects in mice without incidence of sedation or myorelaxation. It is thought that baicalein, along with other flavonoids, may underlie the anxiolytic effects of S. baicalensis and S. lateriflora. Baicalein is also an antagonist of the estrogen receptor, or an antiestrogen . Annotation level-1 Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM. Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.
Scutellarein
Scutellarein is flavone substituted with hydroxy groups at C-4, -5, -6 and -7. It has a role as a metabolite. It is functionally related to an apigenin. It is a conjugate acid of a scutellarein(1-). Scutellarein is a natural product found in Scoparia dulcis, Artemisia douglasiana, and other organisms with data available. Flavone substituted with hydroxy groups at C-4, -5, -6 and -7. Scutellarein, also known as 6-hydroxyapigenin or 4,5,6,7-tetrahydroxyflavanone, is a member of the class of compounds known as flavones. Flavones are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). Thus, scutellarein is considered to be a flavonoid lipid molecule. Scutellarein is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Scutellarein can be synthesized from apigenin. Scutellarein is also a parent compound for other transformation products, including but not limited to, scutellarin, 4,6-dihydroxy-5,7-dimethoxyflavone, and 6-hydroxy-4,5,7-trimethoxyflavone. Scutellarein is a bitter tasting compound found in mexican oregano and sweet orange, which makes scutellarein a potential biomarker for the consumption of these food products. Scutellarein is a flavone that can be found in Scutellaria lateriflora and other members of the genus Scutellaria, as well as the fern Asplenium belangeri . Scutellarein is a natural flavonoid compound with anti-inflammatory effects. Scutellarein is a natural flavonoid compound with anti-inflammatory effects.
Apigenin 7,4'-dimethyl ether
Apigenin 7,4-dimethyl ether, also known as apigenin dimethylether or 4,7-dimethylapigenin, belongs to the class of organic compounds known as 7-O-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, apigenin 7,4-dimethyl ether is considered to be a flavonoid lipid molecule. Apigenin 7,4-dimethyl ether is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, apigenin 7,4-dimethyl ether has been detected, but not quantified in, common sages and sweet basils. This could make apigenin 7,4-dimethyl ether a potential biomarker for the consumption of these foods. BioTransformer predicts that apigenin 7,4-dimethyl ether is a product of 4,5,7-trimethoxyflavone metabolism via an O-dealkylation reaction and catalyzed by CYP2C9 and CYP2C19 enzymes (PMID: 30612223). 4-methylgenkwanin, also known as apigenin dimethylether or 4,7-dimethylapigenin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 4-methylgenkwanin is considered to be a flavonoid lipid molecule. 4-methylgenkwanin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 4-methylgenkwanin can be found in common sage and sweet basil, which makes 4-methylgenkwanin a potential biomarker for the consumption of these food products. Apigenin 7,4-dimethyl ether is a dimethoxyflavone that is the 7,4-dimethyl ether derivative of apigenin. It has a role as a plant metabolite. It is a dimethoxyflavone and a monohydroxyflavone. It is functionally related to an apigenin. Apigenin 7,4-dimethyl ether is a natural product found in Teucrium polium, Calea jamaicensis, and other organisms with data available. A dimethoxyflavone that is the 7,4-dimethyl ether derivative of apigenin. The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Mosloflavone
Mosloflavone is a member of flavonoids and an ether. Mosloflavone is a natural product found in Desmos dumosus, Phonus arborescens, and other organisms with data available. Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation. Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
nepetin
Eupafolin, also known as 6-methoxy 5 or 734-tetrahydroxyflavone, is a member of the class of compounds known as 6-o-methylated flavonoids. 6-o-methylated flavonoids are flavonoids with methoxy groups attached to the C6 atom of the flavonoid backbone. Thus, eupafolin is considered to be a flavonoid lipid molecule. Eupafolin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Eupafolin can be found in common sage, lemon verbena, rosemary, and sesame, which makes eupafolin a potential biomarker for the consumption of these food products. 6-Methoxyluteolin is a natural product found in Eupatorium album, Eupatorium altissimum, and other organisms with data available. See also: Arnica montana Flower (has part). Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2]. Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2].
3K78PYN58P
Licoflavone A is a member of flavones. Licoflavone A is a natural product found in Glycyrrhiza eurycarpa, Glycyrrhiza echinata, and other organisms with data available. See also: Glycyrrhiza inflata root (part of). Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC50 of 54.5 μM[1]. Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC50 of 54.5 μM[1].
Eupatorin
Eupatorin is a trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4, 6 and 7 have been replaced by methyl groups. It has a role as a Brassica napus metabolite, an apoptosis inducer, a vasodilator agent, a calcium channel blocker, an anti-inflammatory agent, a P450 inhibitor and an antineoplastic agent. It is a dihydroxyflavone, a trimethoxyflavone and a polyphenol. It is functionally related to a 6-hydroxyluteolin. Eupatorin is a natural product found in Eupatorium album, Eupatorium altissimum, and other organisms with data available. A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4, 6 and 7 have been replaced by methyl groups. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage[1]. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage[1].
Isoxanthohumol
Isoxanthohumol is a member of flavanones. Isoxanthohumol is a natural product found in Streptomyces, Humulus lupulus, and Sophora flavescens with data available. Isolated from hop (Humulus lupulus). Isoxanthohumol is a biomarker for the consumption of beer. Isoxanthohumol is found in beer and alcoholic beverages. (2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol[1]. (2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol[1]. Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV)[1][2]. Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV)[1][2].
Tangeritin
Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4, 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite. Tangeretin is a natural product found in Citrus tankan, Citrus keraji, and other organisms with data available. See also: Tangerine peel (part of); Citrus aurantium fruit rind (part of). Isolated from tangerine peel and Fortunella japonica (round kumquat). Potential nutriceutical. Tangeritin is found in many foods, some of which are apple, broccoli, sweet bay, and tea. Tangeritin is found in apple. Tangeritin is isolated from tangerine peel and Fortunella japonica (round kumquat). Potential nutriceutica A pentamethoxyflavone flavone with methoxy groups at positions 4, 5, 6 , 7 and 8. Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor. Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.
Licoflavone B
Licoflavone B is a member of flavones. Licoflavone B is a natural product found in Lupinus albus, Glycyrrhiza glabra, and Glycyrrhiza inflata with data available. See also: Glycyrrhiza inflata root (part of). Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC50, 23.78 μM) and ADPase (IC50, 31.50 μM) activity. Anti-schistosomiasis activity[1]. Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC50, 23.78 μM) and ADPase (IC50, 31.50 μM) activity. Anti-schistosomiasis activity[1].
OroxinA
Oroxin A is a natural product found in Scutellaria immaculata, Scutellaria glabrata, and other organisms with data available. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2]. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2]. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2].
Tilianin
Tilianin is a natural product found in Tanacetum vulgare, Linaria kurdica, and other organisms with data available. Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects[1][2][3]. Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects[1][2][3].
Baicalin methyl ester
Baicalin methyl ester is a constituent of the roots of S. baicalmsis[1].
luteolin 3-glucuronide
Luteolin 3-O-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3-position. It has a role as a metabolite. It is a luteolin O-glucuronoside and a trihydroxyflavone. Luteolin 3-o-glucuronide is a natural product found in Salvia, Salvia officinalis, and other organisms with data available. See also: Rosemary (part of). A luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3-position. Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position. Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
Oroxylin A 7-O-beta-D-glucuronide methyl ester
C23H22O11 (474.11620619999997)
Apigenin 6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside
Apigenin 6-C-alpha-L-arabinopyranosyl-8-C-beta-D-xylopyranoside is a natural product found in Viola philippica with data available.
Isoshaftoside
Isoschaftoside is a C-glycosyl compound that is apigenin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively. It has a role as a metabolite. It is a C-glycosyl compound and a trihydroxyflavone. It is functionally related to an apigenin. Isoschaftoside is a natural product found in Centaurea virgata, Galipea trifoliata, and other organisms with data available. A C-glycosyl compound that is apigenin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively. Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles[1][2]. Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles[1][2].
Chrysin 7-O-β-gentiobioside
Chrysin 7-O-beta-gentiobioside is a natural product found in Spartium junceum with data available.
Linarin
Acquisition and generation of the data is financially supported in part by CREST/JST. Linarin is a natural product found in Silene firma, Scoparia dulcis, and other organisms with data available. Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE)[1]. Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE)[1].
Kuwanon_G
Kuwanone G is a tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity. It has a role as an anti-inflammatory agent and a plant metabolite. It is a tetrahydroxyflavone and a member of resorcinols. Kuwanon G is a natural product found in Morus mongolica, Morus alba, and Morus nigra with data available. A tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity. Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity[1][2]. Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity[1][2].
Vaccarin
Vaccarin is a member of flavonoids and a glycoside. Vaccarin is a natural product found in Gypsophila vaccaria with data available. Vaccarin is an active flavonoid glycoside associated with various biological functions. Vaccarin significantly promote wound healing and endothelial cells and fibroblasts proliferation in the wound site. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway[1][2]. Vaccarin is an active flavonoid glycoside associated with various biological functions. Vaccarin significantly promote wound healing and endothelial cells and fibroblasts proliferation in the wound site. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway[1][2]. Vaccarin is an active flavonoid glycoside associated with various biological functions. Vaccarin significantly promote wound healing and endothelial cells and fibroblasts proliferation in the wound site. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway[1][2].
KuwanonH
Kuwanone H is a tetrahydroxyflavone isolated from the plant species of the genus Morus. It has a role as a plant metabolite. It is a tetrahydroxyflavone and a member of resorcinols. Kuwanon H is a natural product found in Morus nigra and Bos taurus with data available. A tetrahydroxyflavone isolated from the plant species of the genus Morus. Kuwanon H is a flavonoid isolated from Morus alba, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1]. Kuwanon H is a flavonoid isolated from Morus alba, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1].
Oroxindin
Wogonin 7-O-beta-D-glucuronide is the glycosyloxyflavone which is the 7-O-glucuronide of wogonin. It is a glycosyloxyflavone, a monomethoxyflavone, a monohydroxyflavone, a monosaccharide derivative and a beta-D-glucosiduronic acid. It is functionally related to a wogonin. It is a conjugate acid of a wogonin 7-O-beta-D-glucuronate. Oroxindin is a natural product found in Scutellaria discolor, Scutellaria indica, and other organisms with data available. See also: Glycyrrhiza Glabra (part of). The glycosyloxyflavone which is the 7-O-glucuronide of wogonin. Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2]. Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2].
Vicenin
Vicenin-3 is a C-glycosyl compound that is apigenin substituted by a beta-D-glucosyl group and a beta-D-xylosyl group at positions 6 and 8 respectively. It has a role as a plant metabolite. It is a C-glycosyl compound and a trihydroxyflavone. It is functionally related to an isovitexin. Vicenin 3 is a natural product found in Rhynchosia minima, Gnetum buchholzianum, and other organisms with data available. A C-glycosyl compound that is apigenin substituted by a beta-D-glucosyl group and a beta-D-xylosyl group at positions 6 and 8 respectively. Vicenin-1 is a natural product found in Linum grandiflorum with data available. Vicenin 3 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=46.91 μM) from the aerial parts of Desmodium styracifolium[1]. Vicenin 3 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=46.91 μM) from the aerial parts of Desmodium styracifolium[1]. Vicenin 1 is a C-glycosylflavone that has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC50=52.50 μM)[1]. Vicenin 1 is a C-glycosylflavone that has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC50=52.50 μM)[1].
Chrysin 6-C-glucoside-8-C-alpha-L-arabinopyranoside
5,7,4-Trihydroxyflavone 6-C-xylopyranoside-8-C-arabinopyranoside
Vitexin 2-O-rhamnoside-4-acetate
Isoorientin 6-O-glucoside
Apigenin 7- (4',6'-diacetylalloside) -4-alloside
6)-beta-D-glucoside
6-Hydroxyluteolin 6,7,3-trimethyl ether 4-glucoside
C24H26O12 (506.14241960000004)
Rhamnellaflavoside A
6-Hydroxyluteolin 6,4-dimethyl ether 7-rutinoside
Isoorientin 4-O-glucoside 2-O-(E)-ferulate
5,8,3,4-Tetrahydroxy-6,7-dimethoxyflavone 8-glucoside
Luteolin 7-methyl ether 5-glucoside
C22H22O11 (462.11620619999997)
Parkinsonin A
C22H22O11 (462.11620619999997)
Isoorientin 4-O-glucoside-2-(4-glucosyloxy-2,5-dihydroxycinnamante)
7-Hydroxy-5,6-dimethoxyflavone 7-glucoside
C23H24O10 (460.13694039999996)
Isoswertisin 2-O-(2-methylbutyrate)
Isoagastachoside
C24H24O11 (488.13185539999995)
Luteolin 7-neohesperidoside-4-sophoroside
Acacetin 7-O-alpha-L-rhamnopyranoside
Artocommunol CA
Luteolin 7,3-dimethyl ether 5-glucoside
C23H24O11 (476.13185539999995)
6-Methoxyluteolin 7-glucuronide methyl ester
Dracocephaloside
Hispidulin 7-(6-E-p-Coumaroylglucoside)
Hydnocarpin
Hydnocarpin is a natural product found in Lonicera japonica and Verbascum sinaiticum with data available. (Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells[1]. (Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells[1].
Scutellarein 7,4-dimethyl ether 6-sophoroside
6)-galactoside
Polystachin (flavone)
6-C-Galactosylisoscutellarein
Isovitexin 7-O-rhamnoside
Luteolin 7-glucuronide-4-rhamnoside
Isovitexin 7-O-galactoside-2-O-glucoside
2-O-(2-Methylbutyryl)orientin
Luteolin 7,4-diglucoside
Dicliripariside C
Isopyrenin
Isoswertisin
Isoviolanthin
Isoviolanthin is a natural product found in Angiopteris evecta and Passiflora sexflora with data available. Isoviolanthin, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells[1]. Isoviolanthin, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells[1].
Chrysoeriol 6-C-glucoside-8-C-arabinopyranoside
Isoscutellarein 4-methyl ether 8-glucuronide
C22H20O12 (476.09547200000003)
Isoorientin 4,2-di-O-glucoside
Eriodictyol 7,3,4-trimethyl ether
Swertiajaponin 3-O-glucoside
8-Hydroxyapigenin 8-sophoroside
Isorientin 4-O-glucoside 2-O-p-hydroxybenzoate
Immaculoside
C23H24O10 (460.13694039999996)
Isocytisoside 3-O-alpha-L-rhamnopyranoside
Dulcinoside
Cucumerin B
2)-(6-acetylglucoside)
Linariin
6-C-Xylosylluteolin
Luteolin 3-methyl ether 5-glucoside
C22H22O11 (462.11620619999997)
Luteolin 3-methyl ether 7-sophorotrioside
Apigenin 7-neohesperidoside-4-sophoroside
6-C-beta-D-Glucopyranosyl-8-C-beta-D-apiofuranosylapigenin
Luteolin 4-methyl ether 7-(6-malonylglucoside)
Orientin 2-acetate
Salvigenin 5-glucoside
C24H26O11 (490.14750460000005)
Vitexin 6-O-glucoside
5-Hydroxy-7,4-dimethoxyflavone 6,8-di-C-arabinopyranoside
Isoorientin 3-O-glucoside
5,7,4-Trihydroxy-6,8,3-trimethoxyflavone 7-glucoside
5,7-Dihydroxy-8-3,4,5-tetramethoxyflavone 5-O-rhamnoside-6-C-glucoside
Isomollupentin 7,4-dimethyl ether 2-O-glucoside
Embigenin 2-(2-acetylrhamnoside)
Orientin 4-O-glucoside-2-O-rhamnoside
4-Hydroxy-5-methoxy-7-(3-methyl-2,3-epoxybutoxy)flavone
Swertiajaponin 3-O-gentiobioside
2'-O-Vanilloylvitexin
2-O-p-Hydroxybenzoylorientin
Isofurcatain
Gossypetin 3-sophoroside-8-glucoside
Artoindonesianin T
Isoaffinetin
C21H20O12 (464.09547200000003)
Acacetin 7-(6-methylglucuronide)
C23H22O11 (474.11620619999997)
Apigenin 7-(3-acetyl-6-E-p-coumaroylglucoside)
Luteolin 5-methyl ether 7-glucoside
C22H22O11 (462.11620619999997)
Dinklagin B
Echioidinin 2-(6-acetylglucoside)
C24H24O11 (488.13185539999995)
Homoeriodictyolchalcone 2-glucoside
C22H24O11 (464.13185539999995)
Molludistin
Isovitexin 7-O-glucoside 2-O-arabinoside
6-Hydroxyluteolin 5-glucoside
C21H20O12 (464.09547200000003)
5,7,3,4-Tetrahydroxy-6,8-dimethoxyflavone 7-glucoside
5,7,3-Trihydroxy-6.8,4-trimethoxyflavone 5-(6-acetylglucoside)
Isovitexin 4,2-di-O-glucoside
Artelastocarpin
Kuwanon O
Kuwanon O is a natural product found in Morus lhou and Morus alba with data available.
Acacetin 7-[2-(2-methylbutyryl)rutinoside]
Isomolludistin
6,8-Di-C-arabinopyranosylapometzgerin
Isoscoparin 2-O-rhamnoside
6-C-Glucopyranosyl-8-C-arabinopyranosyltricin
6-C-Arabinopyranosyl-8-C-glucopyranosyltricin
Isovitexin 4-O-glucoside 2-O-(E)-ferulate
Isoorientin 3-O-glucuronide
Ciliatin A
2)-rhamnoside
Isohemsleyanoside
Isoorientin 2-O-apiofuranoside
8-C-beta-D-Glucofuranosylapigenin 2-O-acetate
C23H22O11 (474.11620619999997)
corymboside
6-C-alpha-L-Arabinopyranosyl-8-C-beta-L-arabinopyranosylapigenin
6-O-beta-L-Arabinopyranosyl-8-C-alpha-L-arabinopyranosylapigenin
Leucanthogenin
Leucanthogenin is a natural product found in Sideritis leucantha with data available.
isomollupentin 7-O-glucoside-2-O-arabinoside
Chrysoeriol 5-methyl ether
6-Methoxytricin
6-Methoxytricin is a natural product found in Conoclinium coelestinum, Eupatorium capillifolium, and other organisms with data available.
5,7,3-Trihydroxy-6,4,5-trimethoxyflavone
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida. 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida.
Canniflavone
Fulvinervin B
6-Prenylapigenin
6-Prenylapigenin is a natural product found in Ficus glumosa, Maclura cochinchinensis, and other organisms with data available.
5,8-dihydroxy-7,4-dimethoxyflavone
5-Hydroxy-7,2,5-trimethoxyflavone
5-Hydroxy-7,2,6-trimethoxyflavone
7,3-Dihydroxy-5,4-dimethoxyflavone
Isothymusin
Isothymusin, also known as 6,7-dimethoxy-5,8,4-trihydroxyflavone, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, isothymusin is considered to be a flavonoid lipid molecule. Isothymusin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Isothymusin can be found in sour cherry, which makes isothymusin a potential biomarker for the consumption of this food product. Isothymusin is a natural product found in Prunus cerasus, Ocimum americanum, and other organisms with data available.
3,4-Dihydroxy-5,6,7-trimethoxyflavone
5-Hydroxy-2,3,7,8-tetramethoxyflavone
5-hydroxy-7,8,2,5tetramethoxyflavone
8,3-Dihydroxy-5,7,4-trimethoxyflavone
Syzalterin
Syzalterin is a natural product found in Pancratium maritimum with data available.
5,3,4-Trihydroxy-7-methoxy-6-methylflavone
6,8-Di-C-methylluteolin 7-methyl ether
5,7-Dimethoxy-3,4-methylenedioxyflavone
7,8-Dimethoxy-3,4-methylenedioxyflavone
7,4-Dihydroxy-8-prenylflavone
Moralbanone
Artocommunol CD
Artoindonesianin R
Millettocalyxin B
5-Methoxy-2,2-dimethyl-8-phenyl-2H,6H-benzo[1,2-b:5,4-b]dipyran-6-one
Carpachromene
8,8-Dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b]dipyran-4-one
Carpachromene dimethyl ether
5-Hydroxy-8-(4-hydroxy-3-methoxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b]dipyran-6-one
9-Methoxy-7-phenyl-5H-furo[3,2-g][1]benzopyran-5-one
Glabratephrinol
Glabratephrin
Semiglabrinol
Multijugin
Multijuginol
Chrysoeriol 7-(3-Z-p-coumaroylglucoside)
2-O-beta-L-galactopyranosylorientin
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect[1][2][3]. 2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect[1][2][3].
Rhamnellaflavoside B
Rhamnellaflavoside C
Luteolin 4-methyl ether 7,3-disulfate
C16H12O12S2 (459.97701920000003)
Scutellarein 7-methyl ether 6-glucoside
C22H22O11 (462.11620619999997)
Pectolinarigenin
Pectolinarigenin is a dimethoxyflavone that is the 6,4-dimethyl ether derivative of scutellarein. It has a role as a plant metabolite. It is a dimethoxyflavone and a dihydroxyflavone. It is functionally related to a scutellarein. Pectolinarigenin is a natural product found in Eupatorium cannabinum, Chromolaena odorata, and other organisms with data available. A dimethoxyflavone that is the 6,4-dimethyl ether derivative of scutellarein. Pectolinarigenin, also known as 5,7-dihydroxy-4,6-dimethoxyflavone or 4-methylcapillarisin, is a member of the class of compounds known as 6-o-methylated flavonoids. 6-o-methylated flavonoids are flavonoids with methoxy groups attached to the C6 atom of the flavonoid backbone. Thus, pectolinarigenin is considered to be a flavonoid lipid molecule. Pectolinarigenin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Pectolinarigenin can be found in sunflower and tarragon, which makes pectolinarigenin a potential biomarker for the consumption of these food products. Pectolinarigenin is a Cirsium isolate with anti-inflammatory activity and belongs to the flavones . Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity[1]. Pectolinarigenin has potent inhibitory activities on melanogenesis[2]. Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity[1]. Pectolinarigenin has potent inhibitory activities on melanogenesis[2]. Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity[1]. Pectolinarigenin has potent inhibitory activities on melanogenesis[2].
6,6-Dimethyl-3,4-methylenedioxypyrano[2,3:7,8]flavone
5-Methoxy-6,6-dimethyl-3,4-methylenedioxypyrano[2,3:7,8]flavone
5,7,2-Trihydroxy-6-methoxyflavone
A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 7 and 2 and a methoxy group at position 6. It has been isolated from the roots of Rubia yunnanensis.
Arteanoflavone
Arteanoflavone is a natural product found in Artemisia lucentica with data available.
Lanceolatin A(flavonoid)
Flavosativaside
Oroxylin A
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5]. Oroxylin A is an active flavonoid compound with strong anti-cancer effects.
Bannamurpanisin
Bannamurpanisin is a natural product found in Neoraputia alba and Murraya paniculata with data available.
Desmodol
Ganhuangenin
Viscidulin III is a compound isolated from the roots of Scutellaria planipes (L.)[1]. Viscidulin III can inhibit the proliferation of HL-60 (IC50= 17.4μM). Viscidulin III is a potential natural tumor inhibitor[2]. Viscidulin III is a compound isolated from the roots of Scutellaria planipes (L.)[1]. Viscidulin III can inhibit the proliferation of HL-60 (IC50= 17.4μM). Viscidulin III is a potential natural tumor inhibitor[2].
Primuletin
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells[1]. 5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells[1].
cis-Tephrostachin
Isocarlinoside
6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucosylluteolin is a C-glycosyl compound that is luteolin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively. It has a role as a metabolite. It is a tetrahydroxyflavone and a C-glycosyl compound. It is functionally related to a luteolin. Isocarlinoside is a natural product found in Glycine max and Lespedeza capitata with data available. A C-glycosyl compound that is luteolin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively.
Apimaysin
Apigenin 8-C- (6'-acetylgalactoside)
C23H22O11 (474.11620619999997)
Apigenin 7-(2-acetylglucoside)
C23H22O11 (474.11620619999997)
Diosmetin
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
2'-O-Feruloylorientin
Isoorientin 6'-O-alpha-L-arabinoside
Isoorientin 2'-O-gallate
Isoorientin 7,3-dimethyl ether
C23H24O11 (476.13185539999995)
A tetrahydroxyflavone that is isoorientin in which the phenolic hydrogens at positions 3 and 7 have been replaced by methyl groups.
Isovitexin 2-O-arabinoside
Isovitexin 2''-O-arabinoside is an inactive flavonoid in plantlets of Avena sativa L.[1]. Isovitexin 2''-O-arabinoside is an inactive flavonoid in plantlets of Avena sativa L.[1].
Luteolin 7- (3'-acetylapiosyl- (1->2) -xyloside)
Diosmin
Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a glycosyloxyflavone, a rutinoside, a disaccharide derivative, a monomethoxyflavone and a dihydroxyflavanone. It is functionally related to a diosmetin. Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile. Diosmin is a natural product found in Asyneuma argutum, Citrus hystrix, and other organisms with data available. A bioflavonoid that strengthens vascular walls. See also: Agathosma betulina leaf (part of). C - Cardiovascular system > C05 - Vasoprotectives > C05C - Capillary stabilizing agents > C05CA - Bioflavonoids C26170 - Protective Agent > C275 - Antioxidant > C306 - Bioflavonoid Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR). Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).
Norwogonin
Norwogonin is a trihydroxyflavone with the hydroxy groups at positions C-5, -7 and -8. It has a role as an antioxidant and a metabolite. Norwogonin is a natural product found in Scutellaria discolor, Scutellaria strigillosa, and other organisms with data available. A trihydroxyflavone with the hydroxy groups at positions C-5, -7 and -8. Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml[1] Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml[1]
Stellarin 2
Tricin 4 -O- (threo-beta-guaiacylglyceryl) ether 7-O-glucopyranoside
5,7,4-Trihydroxy-6,8,3-trimethoxyflavone 4-[6-(3-hydroxy-3-methylglutaryl)glucoside]
Violanthin
A flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5, 7 and 4, a beta-D-glucopyranosyl residue at position 6 and a 6-deoxy-alpha-L-mannopyranosyl residue at position 8. Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM[1]. Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM[1].
Vitexin 2'-O- (E) -ferulate
Vitexin 4-O-galactoside
Isobonducellin
Isobonducellin is a natural product found in Caesalpinia pulcherrima with data available.
5,7-Dimethoxyluteolin
5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC50 of 3.417 μM[1].
3,4-Dimethoxyflavone
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4]. 3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4].
Kuwanon K
Montixanthone
Montixanthone is a natural product found in Hypericum beanii with data available.
Maohuoside B
Yuankanin
Yuankanin is a natural product found in Daphne gnidium and Daphne feddei with data available.
Protoapigenin
2-(1,4-Dihydroxycyclohexa-2,5-dien-1-yl)-5,7-dihydroxychromen-4-one is a natural product found in Macrothelypteris torresiana with data available.
Oroxylin A 7-O-β-D-glucuronide methyl ester
C23H22O11 (474.11620619999997)
Quercetin-3-O-b-D-galactopyranosyl-(1→6)-b-D-glucopyranoside
Kuwanon W
2-(2,4-dihydroxyphenyl)-8-[(1S,5R,6S)-5-(2,4-dihydroxyphenyl)-6-(5-hydroxy-2,2-dimethylchromene-6-carbonyl)-3-methylcyclohex-2-en-1-yl]-5,7-dihydroxy-3-(3-methylbut-2-enyl)chromen-4-one is a natural product found in Morus lhou and Morus alba with data available.
Oprea1_419278
4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1. 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1. 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1.
Graveobioside A
Graveobioside A is a glycoside and a member of flavonoids. Graveobioside A is a natural product found in Capsicum annuum and Centaurea cyanus with data available.
Tetramethylluteolin
3,4,5,7-Tetramethoxyflavone is a natural product found in Orthosiphon aristatus, Bryobium eriaeoides, and other organisms with data available. 5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1]. 5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].
6-Hydroxyflavone
6-Hydroxyflavone is a hydroxyflavonoid. 6-Hydroxyflavone is a natural product found in Scutellaria baicalensis with data available. 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2]. 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
Luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]
Luteolin-7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] is the glycosyloxyflavone resulting from the condensation of the hydroxy group at position 7 of luteolin with the 1 position of 2-O-beta-D-glucopyranuronosyl-beta-D-glucopyranosiduronic acid. It is a trihydroxyflavone, a glycosyloxyflavone, a dicarboxylic acid, a disaccharide derivative and a luteolin O-glucuronoside. It is a conjugate acid of a luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)]. luteolin-7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] is a natural product found in Elodea canadensis, Medicago truncatula, and other organisms with data available. This compound belongs to the family of Flavonoid O-Glycosides. These are compounds containing a carbohydrate moiety which is o-glycosidically linked to one of the flavonoid backbones (2-phenylchromen-4-one, 3-phenylchromen-4-one or 4-phenylcoumarin). The glycosyloxyflavone resulting from the condensation of the hydroxy group at position 7 of luteolin with the 1 position of 2-O-beta-D-glucopyranuronosyl-beta-D-glucopyranosiduronic acid. Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis[1].
Apigenin-7-diglucuronide
(2S,3S,4S,5R,6S)-6-[(2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxane-2-carboxylic acid is a natural product found in Tanacetum parthenium and Artemisia judaica with data available.
Cannabiscitrin
Myricetin 3-O-beta-D-glucopyranoside is a myricetin O-glucoside that is myricetin with a beta-D-glucosyl residue attached at position 3. It has a role as a metabolite. It is a beta-D-glucoside, a monosaccharide derivative, a myricetin O-glucoside, a pentahydroxyflavone and a member of flavonols. It is functionally related to a beta-D-glucose. Cannabiscitrin is a natural product found in Ribes rubrum, Cannabis sativa, and other organisms with data available. A myricetin O-glucoside that is myricetin with a beta-D-glucosyl residue attached at position 3.
Baicalein 7-O-β-D-ethylglucuronide
C23H22O11 (474.11620619999997)
Oprea1_109952
3-Methoxyflavone is a flavonoid compound isolated from Artemisia incanescens with antiviral activity[1][2].
8,3,4-Trihydroxyflavone-7-O-β-D-glucopyranoside
Luteolin-3,7-di-O-glucoside
Acquisition and generation of the data is financially supported in part by CREST/JST.
Luteolin-4-O-glucoside
Annotation level-1 Acquisition and generation of the data is financially supported in part by CREST/JST.
Flavone
Flavone is the simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. It has a role as a metabolite and a nematicide. Flavone is a natural product found in Grindelia hirsutula, Asphodeline damascena, and other organisms with data available. Quercetin is a flavonoid that forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. In studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. For example, it inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. In addition, it exerts potent antioxidant activity and vitamin C-sparing action. Quercetin is a flavonoid that forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. In studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. For example, it inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. In addition, it exerts potent antioxidant activity and vitamin C-sparing action. -- Wikipedia. Flavones (flavus = yellow), are a class of flavonoids based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). Flavones is found in many foods, some of which are dill, feijoa, pomegranate, and rosemary. The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. Flavone is an endogenous metabolite. Flavone is an endogenous metabolite.