Stigmasterol (BioDeep_00000000532)

Main id: BioDeep_00000015505

Secondary id: BioDeep_00000269535, BioDeep_00000859665

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


(3S,8S,9S,10R,13R,14S,17R)-17-((2R,5S,E)-5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

化学式: C29H48O (412.3705)
中文名称: 豆甾醇, 豆固醇
谱图信息: 最多检出来源 Homo sapiens(blood) 36.23%

分子结构信息

SMILES: C1[C@@H](CC2=CC[C@@H]3[C@@H]([C@]2(C1)C)CC[C@]1([C@H]3CC[C@@H]1[C@H](/C=C/[C@@H](C(C)C)CC)C)C)O
InChI: InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-10,19-21,23-27,30H,7,11-18H2,1-6H3/b9-8+/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1

描述信息

Stigmasterol is a phytosterol, meaning it is steroid derived from plants. As a food additive, phytosterols have cholesterol-lowering properties (reducing cholesterol absorption in intestines), and may act in cancer prevention. Phytosterols naturally occur in small amount in vegetable oils, especially soybean oil. One such phytosterol complex, isolated from vegetable oil, is cholestatin, composed of campesterol, stigmasterol, and brassicasterol, and is marketed as a dietary supplement. Sterols can reduce cholesterol in human subjects by up to 15\\%. The mechanism behind phytosterols and the lowering of cholesterol occurs as follows : the incorporation of cholesterol into micelles in the gastrointestinal tract is inhibited, decreasing the overall amount of cholesterol absorbed. This may in turn help to control body total cholesterol levels, as well as modify HDL, LDL and TAG levels. Many margarines, butters, breakfast cereals and spreads are now enriched with phytosterols and marketed towards people with high cholesterol and a wish to lower it. Stigmasterol is found to be associated with phytosterolemia, which is an inborn error of metabolism.
Stigmasterol is a 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions. It has a role as a plant metabolite. It is a 3beta-sterol, a stigmastane sterol, a 3beta-hydroxy-Delta(5)-steroid and a member of phytosterols. It derives from a hydride of a stigmastane.
Stigmasterol is a natural product found in Ficus auriculata, Xylopia aromatica, and other organisms with data available.
Stigmasterol is a steroid derivative characterized by the hydroxyl group in position C-3 of the steroid skeleton, and unsaturated bonds in position 5-6 of the B ring, and position 22-23 in the alkyl substituent. Stigmasterol is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized milk.
See also: Comfrey Root (part of); Saw Palmetto (part of); Plantago ovata seed (part of).
Stigmasterol is an unsaturated plant sterol occurring in the plant fats or oils of soybean, calabar bean, and rape seed, and in a number of medicinal herbs, including the Chinese herbs Ophiopogon japonicus (Mai men dong) and American Ginseng. Stigmasterol is also found in various vegetables, legumes, nuts, seeds, and unpasteurized milk.
A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.
C1907 - Drug, Natural Product > C28178 - Phytosterol > C68437 - Unsaturated Phytosterol

同义名列表

88 个代谢物同义名

(3S,8S,9S,10R,13R,14S,17R)-17-((2R,5S,E)-5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,8S,9S,10R,13R,14S,17R)-17-[(E,1R,4S)-4-ethyl-1,5-dimethyl-hex-2-enyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (1S,2R,5S,10S,11S,14R,15R)-14-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol; 14-((2E)(4S,1R)-4-ethyl-1,5-dimethylhex-2-enyl)(1S,5S,10S,11S,2R,14R,15R)-2,15 -dimethyltetracyclo[8.7.0.0<2,7>.0<11,15>]heptadec-7-en-5-ol; 17-(4-ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; Stigmasterol, certified reference material, 10 mg/mL in chloroform; 3.BETA.-HYDROXY-24-ETHYL-.DELTA.(SUP 5,22)-CHOLESTADIENE; 3beta-HYDROXY-24-ETHYL-delta(SUP 5,22)-CHOLESTADIENE; STIGMASTEROL (CONSTITUENT OF SAW PALMETTO) [DSC]; STIGMASTEROL (CONSTITUENT OF SAW PALMETTO); STIGMASTEROL (CONSTITUENT OF PYGEUM) [DSC]; 3beta-Hydroxy-24-ethyl-5,22-cholestadiene; (24S)-24-Ethylcholesta-5,22-dien-3beta-ol; 24beta-Ethyl-5,22-cholestadien-3beta-ol; 5,22-Cholestadien-24beta-ethyl-3beta-ol; (24S)-24-Ethylcholesta-5,22-dien-3β-ol; Stigmasta-5,22-dien-3-ol, (3beta,22E)-; (3.beta.,22E)-Stigmasta-5,22-dien-3-ol; rac-(24xH)-stigmasta-5,22t-dien-3b-ol; 24-Ethyl-5,22-cholestadien-3.beta.-ol; .delta.5,22-Stigmastadien-3.beta.-ol; (3beta,22E)-Stigmasta-5,22-dien-3-ol; STIGMASTEROL (CONSTITUENT OF PYGEUM); (24x)-ethylcholesta-5,22-dien-3b-ol; Stigmasta-5,22-dien-3-ol, (3b,22E)-; 24-Ethyl-5,22-cholestadien-3beta-ol; 24x-24-ethylcholest-5,22-dien-3b-ol; 5,22-Cholestadien-24-ethyl-3beta-ol; (22E)-stigmasta-5,22-dien-3beta-ol; (24aFH)-stigmasta-5,22t-dien-3b-ol; Stigmasta-5,22-dien-3-ol, (3beta)-; (24S)-5,22-Stigmastadien-3beta-ol; (24xH)-stigmasta-5,22t-dien-3b-ol; 24β-Ethyl-5,22-cholestadien-3β-ol; (24S)-Stigmast-5,22-dien-3beta-ol; (3b,22E)-stigmasta-5,22-dien-3-ol; (3β,22E)-Stigmasta-5,22-dien-3-ol; 24aFH-stigmasta-5,22t-dien-3b-ol; 5,22-Cholestadien-24-ethyl-3β-ol; 5,22-Cholestadien-24-ethyl-3b-ol; GUINEA-PIG-ANTI-STIFFNESS FACTOR; Delta5,22-Stigmastadien-3beta-ol; 24-Ethyl-5,22-cholestadien-3β-ol; Stigmasta-5,22(E)-dien-3beta-ol; (24S)-5,22-stigmastadien-3b-ol; Stigmasta-5,22-dien-3.beta.-ol; (24S)-Stigmast-5,22-dien-3β-ol; (24S)-5,22-Stigmastadien-3β-ol; Stigmasta-5,22E-dien-3beta-ol; Stigmasta-5,22-dien-3-beta-ol; Stigmasta-5,22-dien-3beta-ol; Wulzen anti-stiffness factor; Stigmasta-5,22(E)-dien-3β-ol; HCXVJBMSMIARIN-PHZDYDNGSA-N; stigmasta-5,22t-dien-3b-ol; stigmasta-5,22-dien-3-b-ol; Δ5,22-Stigmastadien-3β-ol; Stigmasta-5,22-dien-3β-ol; Stigmasta-5,22-dien-3b-ol; Stigmasta-5,22-dien-3-ol; .DELTA.5-STIGMASTEROL; STIGMASTEROL [WHO-DD]; .beta.-Stigmasterol; Stigmasterol, ~95\\%; Delta5-Stigmasterol; STIGMASTEROL [HSDB]; beta-Stigmasterol; STIGMASTEROL [MI]; UNII-99WUK5D0Y8; D5-Stigmasterol; Δ5-Stigmasterol; β-Stigmasterol; Poriferasterol; b-stigmasterol; Stigmasterin; Stigmasterol; STIMASTEROL; Phytosterol; Serposterol; 99WUK5D0Y8; ST 29:2;O; 17-(5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; 3β-Hydroxy-24-ethyl-4,22-cholestadiene; (24S)24-Ethylcholesta-5,22-dien-3beta-ol; 5,22-Stigmastadien-3β-ol; Stigmasterol; Poriferasterol



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

123 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

  • plant sterol biosynthesis: 4α-formyl-ergosta-7,24(241)-dien-3β-ol + H+ + O2 + a ferrocytochrome b5 ⟶ 4α-carboxy-ergosta-7,24(241)-dien-3β-ol + H2O + a ferricytochrome b5

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(118)

COVID-19 Disease Map(0)

PathBank(1)

  • Steroid Biosynthesis: Hydrogen Ion + Lathosterol + Oxygen + ferrocytochrome b5 ⟶ 7-Dehydrocholesterol + Water + ferricytochrome b5

PharmGKB(0)

2612 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, ANXA5, BCL2, CASP3, CAT, MAPK8, MTOR, PIK3CA, PTGS2, TP53, VEGFA
Peripheral membrane protein 5 ACHE, ANXA5, CYP1B1, MTOR, PTGS2
Endoplasmic reticulum membrane 5 BCL2, CYP1B1, HMGCR, MTOR, PTGS2
Nucleus 8 ACHE, AKT1, BCL2, CASP3, MAPK8, MTOR, TP53, VEGFA
cytosol 10 AKT1, ANXA5, BCL2, CASP3, CAT, GPT, MAPK8, MTOR, PIK3CA, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 TP53
nucleoplasm 5 AKT1, CASP3, MAPK8, MTOR, TP53
Cell membrane 3 ACHE, AKT1, TNF
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 HMGCR
Golgi apparatus membrane 1 MTOR
Synapse 2 ACHE, MAPK8
cell cortex 1 AKT1
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 2 ACHE, VEGFA
Golgi membrane 2 INS, MTOR
lysosomal membrane 2 GAA, MTOR
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Lysosome 2 GAA, MTOR
plasma membrane 5 ACHE, AKT1, GAA, PIK3CA, TNF
Membrane 11 ACHE, AKT1, ANXA5, BCL2, CAT, CYP1B1, GAA, HMGCR, MTOR, TP53, VEGFA
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CAT, GAA, GPT
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 5 BCL2, HMGCR, PTGS2, TP53, VEGFA
extracellular space 6 ACHE, IL10, IL6, INS, TNF, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ACHE, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CAT, CYP1B1, TP53
protein-containing complex 5 AKT1, BCL2, CAT, PTGS2, TP53
intracellular membrane-bounded organelle 3 CAT, CYP1B1, GAA
Microsome membrane 3 CYP1B1, MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 6 ACHE, GAA, IL10, IL6, INS, VEGFA
extracellular region 9 ACHE, ANXA5, CAT, GAA, IL10, IL6, INS, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
Extracellular side 1 ACHE
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 ANXA5, CAT
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 TP53
phagocytic cup 1 TNF
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
tertiary granule membrane 1 GAA
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Ran Huo, Wen-Jing Yang, Yu Liu, Te Liu, Tong Li, Chu-Yu Wang, Bai-Shen Pan, Bei-Li Wang, Wei Guo. Stigmasterol: Remodeling gut microbiota and suppressing tumor growth through Treg and CD8+ T cells in hepatocellular carcinoma. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155225. doi: 10.1016/j.phymed.2023.155225. [PMID: 38678948]
  • Othman Baothman, Ehab M M Ali, Salman Hosawi, Emadeldin Hassan E Konozy, Isam M Abu Zeid, Abrar Ahmad, Hisham N Altayb. Multi-targeted therapeutic potential of stigmasterol from the Euphorbia ammak plant in treating lung and breast cancer. Computational biology and chemistry. 2024 Jun; 110(?):108037. doi: 10.1016/j.compbiolchem.2024.108037. [PMID: 38460436]
  • Sihong Huang, Rong Zhou, Yuyun Yuan, Yiyun Shen. Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF-β1/Smad2 and IL-17A signaling pathways. Aging. 2024 Apr; 16(7):6478-6487. doi: 10.18632/aging.205716. [PMID: 38579176]
  • Waimei Si, Zhenni Chen, Jing Bei, Shiquan Chang, Yachun Zheng, Li Gao, Guoping Zhao, Xin Li, Di Zhang. Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R. CNS neuroscience & therapeutics. 2024 04; 30(4):e14657. doi: 10.1111/cns.14657. [PMID: 38572785]
  • Xingzhi Guo, Jing Yu, Rui Wang, Ning Peng, Rui Li. Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles. Alzheimer's research & therapy. 2024 Mar; 16(1):53. doi: 10.1186/s13195-024-01424-9. [PMID: 38461353]
  • Laura Stanasila, Dieter Lütjohann, Julius Popp, Pedro Marques-Vidal. Association between Serum Phytosterols and Lipid Levels in a Population-Based Study. Nutrients. 2024 Mar; 16(6):. doi: 10.3390/nu16060775. [PMID: 38542686]
  • Xianbin Zhang, Caihong Wang. Exploration on Anti-Depression Mechanism of Baihe Zhimu Decoction Based on Network Pharmacology and Molecular Docking. Studies in health technology and informatics. 2023 Nov; 308(?):417-427. doi: 10.3233/shti230868. [PMID: 38007768]
  • Zhiqiang Zhang, Jiayi Zhou, Ruiqian Guo, Qijun Zhou, Lianzhi Wang, Xingyan Xiang, Sitong Ge, Zhezhu Cui. Network pharmacology to explore the molecular mechanisms of Prunella vulgaris for treating thyroid cancer. Medicine. 2023 Nov; 102(45):e34871. doi: 10.1097/md.0000000000034871. [PMID: 37960775]
  • Waimei Si, Xin Li, Bei Jing, Shiquan Chang, Yachun Zheng, Zhenni Chen, Guoping Zhao, Di Zhang. Stigmasterol regulates microglial M1/M2 polarization via the TLR4/NF-κB pathway to alleviate neuropathic pain. Phytotherapy research : PTR. 2023 Oct; ?(?):. doi: 10.1002/ptr.8039. [PMID: 37871970]
  • Honghua Zhang, Yunting Sun, Yuqing Zou, Cheng Chen, Shuling Wang. Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation. Journal of ethnopharmacology. 2023 Sep; 319(Pt 2):117193. doi: 10.1016/j.jep.2023.117193. [PMID: 37726069]
  • Linghui Kong, Xinyi Fan, Limin Guo, Qingqing Jiang, Jianbo Xiao, Daming Fan, Mingfu Wang, Yueliang Zhao. Effects of Stigmasterol on 3-Chloropropane-1,2-diol Fatty Acid Esters and Aldehydes Formation in Heated Soybean Oil. Journal of agricultural and food chemistry. 2023 Aug; ?(?):. doi: 10.1021/acs.jafc.3c01584. [PMID: 37551652]
  • Megha Goswami, Priya, Shalini Jaswal, Ghanshyam Das Gupta, Sant Kumar Verma. A comprehensive update on phytochemistry, analytical aspects, medicinal attributes, specifications and stability of stigmasterol. Steroids. 2023 08; 196(?):109244. doi: 10.1016/j.steroids.2023.109244. [PMID: 37137454]
  • Takeshi Sakaki, Tomoko Koizumi, Yosuke Ikeido, Kouichi Soga, Kazuyuki Wakabayashi, Takayuki Hoson. Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions. Life sciences in space research. 2023 Aug; 38(?):53-58. doi: 10.1016/j.lssr.2023.05.005. [PMID: 37481308]
  • Ying Wang, Tao Wang, Zhangtie Wang, Yiwen Guo, Ruijie Liu, Ming Chang. Application of SAXS in exploring the effect of edible oils with different unsaturation FAs on bioaccessibility of stigmasterol oleate. Journal of the science of food and agriculture. 2023 Jul; ?(?):. doi: 10.1002/jsfa.12874. [PMID: 37482970]
  • Yan Xin, Xiang Li, Xuan Zhu, Xiaozhuan Lin, Mengliu Luo, Yunjun Xiao, Yongdui Ruan, Honghui Guo. Stigmasterol Protects Against Steatohepatitis Induced by High-Fat and High-Cholesterol Diet in Mice by Enhancing the Alternative Bile Acid Synthesis Pathway. The Journal of nutrition. 2023 Jun; ?(?):. doi: 10.1016/j.tjnut.2023.05.026. [PMID: 37269906]
  • Md Abu Jobaer, Sania Ashrafi, Monira Ahsan, Choudhury Mahmood Hasan, Mohammad Abdur Rashid, Sheikh Nazrul Islam, Mohammad Mehedi Masud. Phytochemical and Biological Investigation of an Indigenous Plant of Bangladesh, Gynura procumbens (Lour.) Merr.: Drug Discovery from Nature. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104186. [PMID: 37241926]
  • Miki Hatada, Ryota Akiyama, Moeko Yamagishi, Kimitsune Ishizaki, Masaharu Mizutani. MpDWF5A-encoded sterol Δ7-reductase is essential for the normal growth and development of Marchantia polymorpha. Plant & cell physiology. 2023 May; ?(?):. doi: 10.1093/pcp/pcad043. [PMID: 37178336]
  • Maria Kasprzak, Magdalena Rudzińska, Wojciech Juzwa, Anna Olejnik. Anti-proliferative potential and oxidative reactivity of thermo-oxidative degradation products of stigmasterol and stigmasteryl esters for human intestinal cells. Scientific reports. 2023 May; 13(1):7093. doi: 10.1038/s41598-023-34335-0. [PMID: 37127788]
  • Witold Gładkowski, Anna Chojnacka, Aleksandra Włoch, Hanna Pruchnik, Aleksandra Grudniewska, Anna Dunal, Anita Dudek, Gabriela Maciejewska, Magdalena Rudzińska. Conjugates of 1,3- and 1,2-Acylglycerols with Stigmasterol: Synthesis, NMR Characterization, and Impact on Lipid Bilayers. ChemPlusChem. 2023 05; 88(5):e202300161. doi: 10.1002/cplu.202300161. [PMID: 36997498]
  • Zi-Yu Chang, Chun-Wei Chen, Ming-Jun Tsai, Chin-Chang Chen, Abdullah Alshetaili, Yu-Tai Hsiao, Jia-You Fang. The elucidation of structure-activity and structure-permeation relationships for the cutaneous delivery of phytosterols to attenuate psoriasiform inflammation. International immunopharmacology. 2023 Apr; 119(?):110202. doi: 10.1016/j.intimp.2023.110202. [PMID: 37075671]
  • Gugulethu Mathews Miya, Ayodeji Oluwabunmi Oriola, Bianca Payne, Marizé Cuyler, Namrita Lall, Adebola Omowunmi Oyedeji. Steroids and Fatty Acid Esters from Cyperus sexangularis Leaf and Their Antioxidant, Anti-Inflammatory and Anti-Elastase Properties. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083434. [PMID: 37110668]
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