NCBI Taxonomy: 41549
Cirsium (ncbi_taxid: 41549)
found 44 associated metabolites at genus taxonomy rank level.
Ancestor: Carduinae
Child Taxonomies: Cirsium arvense, Cirsium texanum, Cirsium leo, Cirsium canum, Cirsium edule, Cirsium henryi, Cirsium tracyi, Cirsium dender, Cirsium otayae, Cirsium alatum, Cirsium acaule, Cirsium parryi, Cirsium joannae, Cirsium comosum, Cirsium pumilum, Cirsium echinus, Cirsium cymosum, Cirsium eatonii, Cirsium faucium, Cirsium lineare, Cirsium muticum, Cirsium velatum, Cirsium tanakae, Cirsium domonii, Cirsium setosum, Cirsium simplex, Cirsium cassium, Cirsium glabrum, Cirsium souliei, Cirsium ownbeyi, Cirsium vulgare, Cirsium turneri, Cirsium laterifolium, Cirsium barnebyi, Cirsium setidens, Cirsium baytopae, Cirsium foliosum, Cirsium palustre, Cirsium discolor, Cirsium pitcheri, Cirsium wheeleri, Cirsium lecontei, Cirsium alpicola, Cirsium repandum, Cirsium pendulum, Cirsium yezoense, Cirsium grayanum, Cirsium buergeri, Cirsium gyojanum, Cirsium cosmelii, Cirsium creticum, Cirsium handelii, Cirsium rivulare, Cirsium italicum, Cirsium clavatum, Cirsium grahamii, Cirsium spinosum, Cirsium pringlei, Cirsium vinaceum, Cirsium wrightii, Cirsium albertii, Cirsium ashiuense, Cirsium oleraceum, Cirsium undulatum, Cirsium canescens, Cirsium flodmanii, Cirsium inamoenum, Cirsium andrewsii, Cirsium subniveum, Cirsium douglasii, Cirsium fontinale, Cirsium shihianum, Cirsium mohavense, Cirsium komarovii, Cirsium rydbergii, Cirsium scariosum, Cirsium tymphaeum, Cirsium nuttallii, Cirsium aomorense, Cirsium hesperium, Cirsium botryodes, Cirsium schimperi, Cirsium sieversii, Cirsium greimleri, Cirsium dissectum, Cirsium leucopsis, Cirsium tuberosum, Cirsium subinerme, Cirsium pubigerum, Cirsium japonicum, Cirsium sieboldii, Cirsium mexicanum, Cirsium drummondii, Cirsium durangense, Cirsium pulchellum, Cirsium virginense, Cirsium nipponense, Cirsium x vivantii, Cirsium arizonicum, Cirsium bertolonii, Cirsium ciliolatum, Cirsium alsophilum, Cirsium andersonii, Cirsium pyrenaicum, Cirsium suzukaense, Cirsium jorullense, Cirsium purpuratum, Cirsium nipponicum, Cirsium altissimum, Cirsium horridulum, Cirsium buchwaldii, Cirsium elbrusense, Cirsium pannonicum, Cirsium latifolium, Cirsium bulgaricum, Cirsium diacanthum, Cirsium caucasicum, Cirsium hypoleucum, Cirsium shansiense, Cirsium esculentum, Cirsium sairamense, Cirsium conspicuum, Cirsium obvallatum, Cirsium perplexans, Cirsium rhinoceros, Cirsium hookerianum, Cirsium carniolicum, Cirsium alpis-lunae, Cirsium crassicaule, Cirsium brevistylum, Cirsium ehrenbergii, Cirsium hydrophilum, Cirsium coryletorum, Cirsium lomatolepis, Cirsium occidentale, Cirsium quercetorum, Cirsium rhaphilepis, Cirsium pectinellum, Cirsium englerianum, Cirsium erisithales, Cirsium giraudiasii, Cirsium candelabrum, Cirsium libanoticum, Cirsium odontolepis, Cirsium waldsteinii, Cirsium brevifolium, Cirsium helenioides, Cirsium coahuilense, Cirsium engelmannii, Cirsium longistylum, Cirsium virginianum, Cirsium ochrocentrum, unclassified Cirsium, Cirsium monocephalum, Cirsium neomexicanum, Cirsium remotifolium, Cirsium rhothophilum, Cirsium carolinianum, Cirsium vlassovianum, Cirsium acantholepis, Cirsium interpositum, Cirsium polycephalum, Cirsium anartiolepis, Cirsium pulcherrimum, Cirsium subcoriaceum, Cirsium wakasugianum, Cirsium eriophoroides, Cirsium ishizuchiense, Cirsium spinosissimum, Cirsium amplexifolium, Cirsium leucocephalum, Cirsium brevipapposum, Cirsium kamtschaticum, Cirsium heterophyllum, Cirsium microspicatum, Cirsium oblongifolium, Cirsium serratuloides, Cirsium ochrolepidium, Cirsium heterotrichum, Cirsium rhizocephalum, Cirsium x glabrifolium, Cirsium monspessulanum, Cirsium appendiculatum, Cirsium straminispinum, Cirsium brachycephalum, Cirsium confertissimum, Cirsium pseudopersonata, Cirsium fanjingshanense, Cirsium grandirosuliferum, Cirsium cf. muticum DAOM 204851
Luteolin
Luteolin is a naturally occurring flavonoid. (PMID:17168665). The flavonoids are polyphenolic compounds found as integral components of the human diet. They are universally present as constituents of flowering plants, particularly of food plants. The flavonoids are phenyl substituted chromones (benzopyran derivatives) consisting of a 15-carbon basic skeleton (C6-C3-C6), composed of a chroman (C6-C3) nucleus (the benzo ring A and the heterocyclic ring C), also shared by the tocopherols, with a phenyl (the aromatic ring B) substitution usually at the 2-position. Different substitutions can typically occur in the rings, A and B. Several plants and spices containing flavonoid derivatives have found application as disease preventive and therapeutic agents in traditional medicine in Asia for thousands of years. The selection of a particular food plant, plant tissue or herb for its potential health benefits appears to mirror its flavonoid composition. The much lower risk of colon, prostate and breast cancers in Asians, who consume more vegetables, fruits and tea than populations in the Western hemisphere do, raises the question of whether flavonoid components mediate the protective effects of diets rich in these foodstuffs by acting as natural chemopreventive and anticancer agents. An impressive body of information exists on the antitumoral action of plant flavonoids. In vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior. Furthermore, some studies have reported the impairment of in vivo angiogenesis by dietary flavonoids. Experimental animal studies indicate that certain dietary flavonoids possess antitumoral activity. The hydroxylation pattern of the B ring of the flavones and flavonols, such as luteolin seems to critically influence their activities, especially the inhibition of protein kinase activity and antiproliferation. The different mechanisms underlying the potential anticancer action of plant flavonoids await further elucidation. Certain dietary flavonols and flavones targeting cell surface signal transduction enzymes, such as protein tyrosine and focal adhesion kinases, and the processes of angiogenesis appear to be promising candidates as anticancer agents. Further in vivo studies of these bioactive constituents is deemed necessary in order to develop flavonoid-based anticancer strategies. In view of the increasing interest in the association between dietary flavonoids and cancer initiation and progression, this important field is likely to witness expanded effort and to attract and stimulate further vigorous investigations (PMID:16097445). Luteolin is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 4, 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. It has a role as an EC 2.3.1.85 (fatty acid synthase) inhibitor, an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a plant metabolite, a nephroprotective agent, an angiogenesis inhibitor, a c-Jun N-terminal kinase inhibitor, an anti-inflammatory agent, an apoptosis inducer, a radical scavenger and an immunomodulator. It is a 3-hydroxyflavonoid and a tetrahydroxyflavone. It is a conjugate acid of a luteolin-7-olate. Luteolin is a natural product found in Verbascum lychnitis, Carex fraseriana, and other organisms with data available. Luteolin is a naturally-occurring flavonoid, with potential anti-oxidant, anti-inflammatory, apoptosis-inducing and chemopreventive activities. Upon administration, luteolin scavenges free radicals, protects cells from reactive oxygen species (ROS)-induced damage and induces direct cell cycle arrest and apoptosis in tumor cells. This inhibits tumor cell proliferation and suppresses metastasis. 5,7,3,4-tetrahydroxy-flavone, one of the FLAVONES. See also: Chamomile (part of); Cannabis sativa subsp. indica top (part of); Fenugreek seed (part of). A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 4, 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. Flavone v. widespread in plant world; found especies in celery, peppermint, rosemary, thyme and Queen Annes Lace leaves (wild carrot). Potential nutriceutical. Luteolin is found in many foods, some of which are soy bean, ginger, abalone, and swiss chard. Acquisition and generation of the data is financially supported in part by CREST/JST. IPB_RECORD: 361; CONFIDENCE confident structure CONFIDENCE standard compound; INTERNAL_ID 48 Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2][3]. Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2][3].
Syringin
Syringin is a monosaccharide derivative that is trans-sinapyl alcohol attached to a beta-D-glucopyranosyl residue at position 1 via a glycosidic linkage. It has a role as a hepatoprotective agent and a plant metabolite. It is a beta-D-glucoside, a monosaccharide derivative, a primary alcohol and a dimethoxybenzene. It is functionally related to a trans-sinapyl alcohol. Syringin is a natural product found in Salacia chinensis, Codonopsis lanceolata, and other organisms with data available. See also: Codonopsis pilosula root (part of). A monosaccharide derivative that is trans-sinapyl alcohol attached to a beta-D-glucopyranosyl residue at position 1 via a glycosidic linkage. Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy[1][2]. Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy[1][2].
Vicinin 2
Vicinin 2 is found in citrus. Vicinin 2 is a constituent of lemon (Citrus limon) peel and sugar cane syrup. Constituent of lemon (Citrus limon) peel and sugar cane syrup. Vicinin 2 is found in citrus.
1-Pentadecene
1-Pentadecene, also known as pentadec-1-ene, belongs to the class of organic compounds known as unsaturated aliphatic hydrocarbons. These are aliphatic Hydrocarbons that contains one or more unsaturated carbon atoms. 1-Pentadecene is an unbranched fifteen-carbon alkene with one double bond between C-1 and C-2. These compounds contain one or more double or triple bonds. Thus, 1-pentadecene is considered to be a hydrocarbon lipid molecule. 1-Pentadecene is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. 1-Pentadecene is found, on average, in the highest concentration within safflowers. 1-Pentadecene has also been detected, but not quantified, in burdocks and watermelons. This could make 1-pentadecene a potential biomarker for the consumption of these foods. Occurs in beef and oakmoss oleoresin. 1-Pentadecene is found in many foods, some of which are animal foods, burdock, safflower, and watermelon.
Lupenone
1,2,5,14,18,18-hexamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicosan-17-one belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. 1,2,5,14,18,18-hexamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicosan-17-one is an extremely weak basic (essentially neutral) compound (based on its pKa). This compound has been identified in human blood as reported by (PMID: 31557052 ). Lupenone is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically Lupenone is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.
1-Heptadecene
1-heptadecene is a member of the class of compounds known as unsaturated aliphatic hydrocarbons. Unsaturated aliphatic hydrocarbons are aliphatic Hydrocarbons that contains one or more unsaturated carbon atoms. These compounds contain one or more double or triple bonds. Thus, 1-heptadecene is considered to be a hydrocarbon lipid molecule. 1-heptadecene can be found in burdock and safflower, which makes 1-heptadecene a potential biomarker for the consumption of these food products.
(Z,Z)-1,8,11-Heptadecatriene
(z,z)-1,8,11-heptadecatriene is a member of the class of compounds known as alkatrienes. Alkatrienes are acyclic hydrocarbons that contain exactly three carbon-to-carbon double bonds (z,z)-1,8,11-heptadecatriene can be found in burdock and safflower, which makes (z,z)-1,8,11-heptadecatriene a potential biomarker for the consumption of these food products.
Luteolin
Annotation level-1 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.976 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.975 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.968 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.971 Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2][3]. Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2][3].
Lupenone
Lupenone, isolated from Musa basjoo, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity[1][2]. Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities[1][2][3]. Lupenone, isolated from Musa basjoo, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity[1][2].
syringin
Syringin, also known as eleutheroside b or beta-terpineol, is a member of the class of compounds known as phenolic glycosides. Phenolic glycosides are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose. Syringin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Syringin can be found in caraway, fennel, and lemon, which makes syringin a potential biomarker for the consumption of these food products. Syringin is a natural chemical compound first isolated from the bark of lilac (Syringa vulgaris) by Meillet in 1841. It has since been found to be distributed widely throughout many types of plants. It is also called eleutheroside B, and is found in Eleutherococcus senticosus (Siberian ginseng). It is also found in dandelion coffee . Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy[1][2]. Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy[1][2].
Vicinin 2
1-PENTADECENE
An unbranched fifteen-carbon alkene with one double bond between C-1 and C-2.
24-methylenecycloartanol
A pentacyclic triterpenoid that is (9beta)-24-methylene-9,19-cyclolanostane which carries a hydroxy group at position 3beta. It is isolated from several plant species including Euphorbia, Epidendrum, Psychotria and Sideritis.
5-{[(5-formylfuran-2-yl)methoxy]methyl}furan-2-carbaldehyde
(8r,9s,10r)-10-chloroheptadec-16-en-4,6-diyne-8,9-diol
(1r,3ar,3br,7s,9ar,9br,11ar)-1-[(2s,3e,5s)-5-ethyl-6-methylhept-3-en-2-yl]-9a,11a-dimethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-ol
(5r,9r,12as,13s,15s,15as,16s,18as)-16-benzyl-5,13,18-trihydroxy-9,15-dimethyl-14-methylidene-5h,6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindol-2-one
C29H37NO5 (479.26715920000004)
(3s,4ar,6br,8ar,12s,12ar,12br,14ar,14br)-4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-hexadecahydropicen-3-yl acetate
(1r,7r,10r)-10,11,11-trimethyltricyclo[5.3.1.0¹,⁵]undec-4-ene-4-carbaldehyde
(1e,5r,10s,11s,14s)-4-ethyl-10,14-dihydroxy-5-[(1s)-1-hydroxyethyl]-11-methoxy-12-oxa-4-azatricyclo[9.2.1.0²,⁵]tetradec-1-en-3-one
5,7-dihydroxy-2-(3-hydroxy-4-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-6-methoxychromen-4-one
(3ar,4r,4ar,6s,7ar,9as)-6-hydroxy-3,5,8-trimethylidene-2-oxo-octahydroazuleno[6,5-b]furan-4-yl 2-(hydroxymethyl)prop-2-enoate
10,11,11-trimethyltricyclo[5.3.1.0¹,⁵]undec-4-ene-4-carbaldehyde
9,10-dihydroxyheptadec-1-en-11,13-diyn-8-yl acetate
(3as,6ar,9ar,9bs)-6,9-dimethylidene-octahydro-3h-azuleno[4,5-b]furan-2-one
(8r,9s,10s)-10-methoxyheptadec-16-en-4,6-diyne-8,9-diol
20-benzyl-6,22-dihydroxy-17,18-dimethyl-2,16-dioxa-21-azatetracyclo[12.8.0.0¹,¹⁹.0¹⁵,¹⁷]docosa-4,12,21-trien-3-one
C28H35NO5 (465.25151000000005)