Luteolin (BioDeep_00000000156)

 

Secondary id: BioDeep_00000270107

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Antitumor activity BioNovoGene_Lab2019


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one

化学式: C15H10O6 (286.0477)
中文名称: 木樨草素, 毛地黄黄酮, 3',4',5,7-四羟基黄酮, 木犀草素
谱图信息: 最多检出来源 Homo sapiens(feces) 39.06%

Reviewed

Last reviewed on 2024-08-22.

Cite this Page

Luteolin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/luteolin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000156). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1(O)C=C2OC(C3=CC(O)=C(O)C=C3)=CC(=O)C2=C(O)C=1
InChI: InChI=1/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

描述信息

Luteolin is a naturally occurring flavonoid. (PMID:17168665). The flavonoids are polyphenolic compounds found as integral components of the human diet. They are universally present as constituents of flowering plants, particularly of food plants. The flavonoids are phenyl substituted chromones (benzopyran derivatives) consisting of a 15-carbon basic skeleton (C6-C3-C6), composed of a chroman (C6-C3) nucleus (the benzo ring A and the heterocyclic ring C), also shared by the tocopherols, with a phenyl (the aromatic ring B) substitution usually at the 2-position. Different substitutions can typically occur in the rings, A and B. Several plants and spices containing flavonoid derivatives have found application as disease preventive and therapeutic agents in traditional medicine in Asia for thousands of years. The selection of a particular food plant, plant tissue or herb for its potential health benefits appears to mirror its flavonoid composition. The much lower risk of colon, prostate and breast cancers in Asians, who consume more vegetables, fruits and tea than populations in the Western hemisphere do, raises the question of whether flavonoid components mediate the protective effects of diets rich in these foodstuffs by acting as natural chemopreventive and anticancer agents. An impressive body of information exists on the antitumoral action of plant flavonoids. In vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior. Furthermore, some studies have reported the impairment of in vivo angiogenesis by dietary flavonoids. Experimental animal studies indicate that certain dietary flavonoids possess antitumoral activity. The hydroxylation pattern of the B ring of the flavones and flavonols, such as luteolin seems to critically influence their activities, especially the inhibition of protein kinase activity and antiproliferation. The different mechanisms underlying the potential anticancer action of plant flavonoids await further elucidation. Certain dietary flavonols and flavones targeting cell surface signal transduction enzymes, such as protein tyrosine and focal adhesion kinases, and the processes of angiogenesis appear to be promising candidates as anticancer agents. Further in vivo studies of these bioactive constituents is deemed necessary in order to develop flavonoid-based anticancer strategies. In view of the increasing interest in the association between dietary flavonoids and cancer initiation and progression, this important field is likely to witness expanded effort and to attract and stimulate further vigorous investigations (PMID:16097445).
Luteolin is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 4, 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. It has a role as an EC 2.3.1.85 (fatty acid synthase) inhibitor, an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a plant metabolite, a nephroprotective agent, an angiogenesis inhibitor, a c-Jun N-terminal kinase inhibitor, an anti-inflammatory agent, an apoptosis inducer, a radical scavenger and an immunomodulator. It is a 3-hydroxyflavonoid and a tetrahydroxyflavone. It is a conjugate acid of a luteolin-7-olate.
Luteolin is a natural product found in Verbascum lychnitis, Carex fraseriana, and other organisms with data available.
Luteolin is a naturally-occurring flavonoid, with potential anti-oxidant, anti-inflammatory, apoptosis-inducing and chemopreventive activities. Upon administration, luteolin scavenges free radicals, protects cells from reactive oxygen species (ROS)-induced damage and induces direct cell cycle arrest and apoptosis in tumor cells. This inhibits tumor cell proliferation and suppresses metastasis.
5,7,3,4-tetrahydroxy-flavone, one of the FLAVONES.
See also: Chamomile (part of); Cannabis sativa subsp. indica top (part of); Fenugreek seed (part of).
A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 4, 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.
Flavone v. widespread in plant world; found especies in celery, peppermint, rosemary, thyme and Queen Annes Lace leaves (wild carrot). Potential nutriceutical. Luteolin is found in many foods, some of which are soy bean, ginger, abalone, and swiss chard.
Acquisition and generation of the data is financially supported in part by CREST/JST.
IPB_RECORD: 361; CONFIDENCE confident structure
CONFIDENCE standard compound; INTERNAL_ID 48
Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2][3].
Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2][3].

同义名列表

60 个代谢物同义名

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; 4H-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-benzopyrone-4-one; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-benzopyran-4-one; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one #; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Luteolin, primary pharmaceutical reference standard; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-chromenone; 23A002A4-B47B-46CD-848C-65042EACF3FF; Luteolin, >=98\\% (TLC), powder; FLAVONE, 3,4,5,7-TETRAHYDROXY-; 5,7,3’,4’-Tetrahydroxyflavone; Luteolin, analytical standard; 3’,4’,5,7-Tetrahydroxyflavone; 3,4,5,7-Tetrahydroxy-Flavone; 5,7,3,4-Tetrahydroxyflavone; 3,4,5,7-Tetrahydroxyflavone; Luteolin, >=99.0\\% (TLC); C.I. Natural Yellow 2; 7-Tetrahydroxyflavone; Luteolin (Standard); Prestwick3_000870; Prestwick0_000870; LUTEOLIN [WHO-DD]; Prestwick1_000870; Prestwick2_000870; UNII-KUX1ZNC9J2; LUTEOLIN [INCI]; Daphneflavonol; MEGxp0_000143; LUTEOLIN [MI]; Oprea1_849964; Digitoflavone; Lopac0_000660; BPBio1_001011; Yama kariyasu; Luteolin,(S); ACon1_000223; Flavopurpol; SMP2_000042; KUX1ZNC9J2; Salifazide; Cyanidenon; Weld Lake; Luteoline; Flacitran; Luteolin; Luteolol; Bismite; Lutl; 4hkn; 4dgn; 4dew; LU2; 3 4 5 7-tetrahydroxyflavone; Luteolin



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

226 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(225)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

3117 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 CCND1, CDK1, CTNNB1, HIF1A, MAPK14, NFKB1, PTGS2, TNK1, TYR, XDH
Peripheral membrane protein 4 ACHE, CYP1B1, PTGS2, TNK1
Endoplasmic reticulum membrane 3 CDK1, CYP1B1, PTGS2
Nucleus 8 ACHE, CCND1, CDK1, CTNNB1, HIF1A, MAPK14, MMP2, NFKB1
cytosol 8 CCND1, CDK1, CTNNB1, HIF1A, IL1B, MAPK14, NFKB1, XDH
nuclear body 1 HIF1A
centrosome 3 CCND1, CDK1, CTNNB1
nucleoplasm 6 CCND1, CDK1, CTNNB1, HIF1A, MAPK14, NFKB1
RNA polymerase II transcription regulator complex 1 HIF1A
Cell membrane 2 ACHE, CTNNB1
lamellipodium 1 CTNNB1
Synapse 2 ACHE, CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 1 ACHE
glutamatergic synapse 2 CTNNB1, MAPK14
Golgi apparatus 1 ACHE
Golgi membrane 1 INS
lysosomal membrane 1 EGF
neuromuscular junction 1 ACHE
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 IL1B
Lysosome 2 IL1B, TYR
plasma membrane 6 ACHE, CTNNB1, EGF, IGHE, MMP2, TNK1
Membrane 6 ACHE, CDK1, CTNNB1, CYP1B1, EGF, TNK1
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 4 CDK1, CTNNB1, EGF, MMP9
endoplasmic reticulum 1 PTGS2
extracellular space 10 ACHE, CXCL8, EGF, IGHE, IL1B, IL4, INS, MMP2, MMP9, XDH
perinuclear region of cytoplasm 3 ACHE, CTNNB1, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
mitochondrion 5 CDK1, CYP1B1, MAPK14, MMP2, NFKB1
protein-containing complex 3 CTNNB1, HIF1A, PTGS2
intracellular membrane-bounded organelle 2 CYP1B1, TYR
Microsome membrane 2 CYP1B1, PTGS2
Single-pass type I membrane protein 2 IGHE, TYR
Secreted 5 ACHE, CXCL8, IL1B, IL4, INS
extracellular region 11 ACHE, CXCL8, EGF, IGHE, IL1B, IL4, INS, MAPK14, MMP2, MMP9, NFKB1
mitochondrial matrix 1 CDK1
Extracellular side 1 ACHE
transcription regulator complex 2 CTNNB1, NFKB1
motile cilium 1 HIF1A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK1
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
Secreted, extracellular space, extracellular matrix 1 MMP9
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
axon cytoplasm 1 HIF1A
Melanosome membrane 1 TYR
midbody 1 CDK1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
Golgi-associated vesicle 1 TYR
postsynaptic membrane 1 CTNNB1
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 1 CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 MMP2
Peroxisome 1 XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 2 MMP2, MMP9
secretory granule 1 IL1B
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 HIF1A, MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
sarcomere 1 MMP2
neuron projection 1 PTGS2
chromatin 2 HIF1A, NFKB1
IgE immunoglobulin complex 1 IGHE
cell periphery 1 CTNNB1
mitotic spindle 1 CDK1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 2 CTNNB1, MAPK14
chromosome, telomeric region 1 CDK1
postsynaptic density, intracellular component 1 CTNNB1
Lipid-anchor, GPI-anchor 1 ACHE
microvillus membrane 1 CTNNB1
[Isoform 2]: Cell membrane 1 IGHE
Endomembrane system 1 CTNNB1
endosome lumen 1 INS
Melanosome 1 TYR
Nucleus speckle 1 HIF1A
euchromatin 2 CTNNB1, HIF1A
side of membrane 1 ACHE
ficolin-1-rich granule lumen 2 MAPK14, MMP9
secretory granule lumen 3 INS, MAPK14, NFKB1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 EGF
specific granule lumen 1 NFKB1
tertiary granule lumen 1 MMP9
transport vesicle 1 INS
[Isoform 1]: Secreted, extracellular space, extracellular matrix 1 MMP2
beta-catenin-TCF complex 1 CTNNB1
Secreted, extracellular exosome 1 IL1B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 1 EGF
synaptic cleft 1 ACHE
protein-DNA complex 1 CTNNB1
spindle microtubule 1 CDK1
catenin complex 1 CTNNB1
[Isoform 3]: Cell membrane 1 IGHE
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDK1
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
cyclin D1-CDK4 complex 1 CCND1
beta-catenin-TCF7L2 complex 1 CTNNB1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1


文献列表

  • Xiao-Ke Shi, Ting Peng, Bahtigul Azimova, Xiao-Li Li, Shan-Shan Li, Dong-Yi Cao, Nai-Jie Fu, Guo-Lin Zhang, Wei-Lie Xiao, Fei Wang. Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2. Journal of ethnopharmacology. 2024 Sep; 331(?):118279. doi: 10.1016/j.jep.2024.118279. [PMID: 38705425]
  • Pincha Devage Sameera Madushan Fernando, Dong Ok Ko, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, Jin Won Hyun. Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems. Molecular medicine reports. 2024 07; 30(1):. doi: 10.3892/mmr.2024.13244. [PMID: 38757300]
  • Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of ethnopharmacology. 2024 Jun; 327(?):117999. doi: 10.1016/j.jep.2024.117999. [PMID: 38447616]
  • Shuang Chai, Yanbing Yang, Liwei Wei, Yuju Cao, Jiangtao Ma, Xuxia Zheng, Junyan Teng, Na Qin. Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155516. doi: 10.1016/j.phymed.2024.155516. [PMID: 38547625]
  • Xiao-Yu Zhang, Kai-Rou Xia, Ya-Ni Wang, Pei Liu, Er-Xin Shang, Cong-Yan Liu, Yu-Ping Liu, Ding Qu, Wei-Wen Li, Jin-Ao Duan, Yan Chen, Huang-Qin Zhang. Unraveling the pharmacodynamic substances and possible mechanism of Trichosanthis Pericarpium in the treatment of coronary heart disease based on plasma pharmacochemistry, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 325(?):117869. doi: 10.1016/j.jep.2024.117869. [PMID: 38342153]
  • Yoko Murakami, Toshiyasu Imaizumi, Kouhei Hashizume, Yu Tezuka, Yusuke Oku, Naoyuki Nishiya, Atsushi Sanbe, Daijiro Kurosaka. Inhibition of Connective Tissue Growth Factor Expression in Adult Retinal Pigment Epithelial-19 Cells by Blocking Yes-Associated Protein/Transcriptional Coactivator with PDZ-Binding Motif Activity. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2024 May; 40(4):246-252. doi: 10.1089/jop.2023.0141. [PMID: 38517736]
  • Anna Balykina, Lidia Naida, Kürsat Kirkgöz, Viacheslav O Nikolaev, Ekaterina Fock, Michael Belyakov, Anastasiia Whaley, Andrei Whaley, Valentina Shpakova, Natalia Rukoyatkina, Stepan Gambaryan. Antiplatelet Effects of Flavonoid Aglycones Are Mediated by Activation of Cyclic Nucleotide-Dependent Protein Kinases. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094864. [PMID: 38732081]
  • Dan Jiang, Ziliang Li, Hongyan Liu, Huihui Liu, Xiaoyang Xia, Xia Xiang. Plant exosome-like nanovesicles derived from sesame leaves as carriers for luteolin delivery: Molecular docking, stability and bioactivity. Food chemistry. 2024 Apr; 438(?):137963. doi: 10.1016/j.foodchem.2023.137963. [PMID: 37976878]
  • Yiwei Zhou, Yuhan Huang, Wei Ye, Zijie Chen, Zhengzhong Yuan. Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116425. doi: 10.1016/j.biopha.2024.116425. [PMID: 38490155]
  • Sahar Saleh Alghamdi, Sara Abdulaziz Alghashem, Rizwan Ali, Arwa Alsubait, Rasha Saad Suliman, Afrah E Mohammed, Zeyad Alehaideb, Raghad Abdullah Alshafi, Allulu Yousef Alturki, Ishrat Rahman. Exploring the potential of Ziziphus nummularia and luteolin-7-O-glucoside as tubulin inhibitors in cancer therapy and survival. Scientific reports. 2024 03; 14(1):7202. doi: 10.1038/s41598-024-57680-0. [PMID: 38531974]
  • Xiaojuan Yang, Feifei Li, Youyang Shi, Yuanyuan Wu, Rui Yang, Xiaofei Liu, Yang Zhang, Guangtao Zhang, Mei Ma, Zhanyang Luo, Xianghui Han, Ying Xie, Sheng Liu. Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer. Acta biochimica et biophysica Sinica. 2024 Mar; 56(5):763-775. doi: 10.3724/abbs.2024015. [PMID: 38516703]
  • Javad Ghasemian-Yadegari, Ahmad Adineh, Hamidreza Mohammadi, Shima Davari, Yousef Veisani, Hori Ghaneialvar, Ali Aidy, Naser Abbasi, Elahe Karimi. Attenuation of cannabis withdrawal symptoms by Prosopis farcta extract, its luteolin and melatonin in mice: Involvement of brain-derived neurotrophic factor and dopamine. Cell biochemistry and function. 2024 Mar; 42(2):e3980. doi: 10.1002/cbf.3980. [PMID: 38491827]
  • Jiake Gu, Peiying Zhang, Huajun Li, Yisen Wang, Ying Huang, Lei Fan, Xiao Ma, Xiaodong Qian, Juqun Xi. Cerium-Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation. ACS nano. 2024 Feb; 18(8):6229-6242. doi: 10.1021/acsnano.3c09528. [PMID: 38345570]
  • Saleh A Almatroodi, Ahmad Almatroudi, Hajed Obaid A Alharbi, Amjad Ali Khan, Arshad Husain Rahmani. Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051093. [PMID: 38474604]
  • Ji-Yun Kang, Ji-Yeon Gu, Dong-Cheol Baek, Chang-Gue Son, Jin-Seok Lee. A Capsicum annuum L. seed extract exerts anti-neuroexcitotoxicity in HT22 hippocampal neurons. Food & function. 2024 Feb; ?(?):. doi: 10.1039/d3fo04501c. [PMID: 38305768]
  • Yang Ye, Chen Xiaoyang, Yao Junkai, H U Yueyao, Wang Wei. Efficacy of Danlou tablet on myocardial ischemia/ reperfusion injury assessed by network pharmacology and experimental verification. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):131-144. doi: 10.19852/j.cnki.jtcm.20231121.003. [PMID: 38213248]
  • Haifeng Liu, Yaqin Chen, Yilong Hu, Wenrui Zhang, Hui Zhang, Tianli Su, Juan Wang, Zhongqiong Yin, Xinhong Zhao, Xun Zhou, Lixia Li, Yuanfeng Zou, Yuping Fu, Yingying Zhang, Xu Song. Protective effects of an alcoholic extract of Kaempferia galanga L. rhizome on ethanol-induced gastric ulcer in mice. Journal of ethnopharmacology. 2024 Jan; ?(?):117845. doi: 10.1016/j.jep.2024.117845. [PMID: 38307355]
  • Yinai Deng, Peng Yang, Qianle Zhang, Qingwen Wu, Lingfang Feng, Wenjing Shi, Qian Peng, Li Ding, Xukai Tan, Ruoting Zhan, Dongming Ma. Genomic insights into the evolution of flavonoid biosynthesis and O-methyltransferase and glucosyltransferase in Chrysanthemum indicum. Cell reports. 2024 Jan; 43(2):113725. doi: 10.1016/j.celrep.2024.113725. [PMID: 38300800]
  • Eman Shawky, Rasha A Nassra, Aliaa M T El-Alkamy, Shaimaa M Sallam, Samah M El Sohafy. Unraveling the mechanisms of Fenugreek seed for managing different gynecological disorders: steroidal saponins and isoflavones revealed as key bioactive metabolites. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115865. doi: 10.1016/j.jpba.2023.115865. [PMID: 38000191]
  • Michalis K Stefanakis, Olga St Tsiftsoglou, Pavle Z Mašković, Diamanto Lazari, Haralambos E Katerinopoulos. Chemical Constituents and Anticancer Activities of the Extracts from Phlomis × commixta Rech. f. (P. cretica × P. lanata). International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020816. [PMID: 38255889]
  • Wanli Zhao, Long Huang, Shu Xu, Junzhi Wu, Fan Wang, Pirui Li, Linwei Li, Mei Tian, Xu Feng, Yu Chen. Identification of One O-Methyltransferase Gene Involved in Methylated Flavonoid Biosynthesis Related to the UV-B Irradiation Response in Euphorbia lathyris. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020782. [PMID: 38255854]
  • Karan Mediratta, Sara El-Sahli, Marie Marotel, Muhammad Z Awan, Melanie Kirkby, Ammar Salkini, Reem Kurdieh, Salman Abdisalam, Amit Shrestha, Chiara Di Censo, Andrew Sulaiman, Sarah McGarry, Jessie R Lavoie, Zhen Liu, Seung-Hwan Lee, Xuguang Li, Giuseppe Sciumè, Vanessa M D'Costa, Michele Ardolino, Lisheng Wang. Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model. Frontiers in immunology. 2024; 15(?):1366197. doi: 10.3389/fimmu.2024.1366197. [PMID: 38601156]
  • Teng Fan, Yuanyuan Huang, Zeyu Liu, Jinsheng Huang, Bin Ke, Yuming Rong, Huijuan Qiu, Bei Zhang. Unveiling the Mechanism of the ChaiShao Shugan Formula Against Triple-Negative Breast Cancer. Drug design, development and therapy. 2024; 18(?):1115-1131. doi: 10.2147/dddt.s394287. [PMID: 38618280]
  • Zhe Yu, Ruoqi Ding, Qiuju Yan, Menghan Cheng, Teng Li, Fei Zheng, Lin Zhu, Yang Wang, Tao Tang, En Hu. A Novel Network Pharmacology Strategy Based on the Universal Effectiveness-Common Mechanism of Medical Herbs Uncovers Therapeutic Targets in Traumatic Brain Injury. Drug design, development and therapy. 2024; 18(?):1175-1188. doi: 10.2147/dddt.s450895. [PMID: 38645986]
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