beta-Sitosterol (BioDeep_00000000534)

 

Secondary id: BioDeep_00000266605, BioDeep_00000295454, BioDeep_00000859590

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs


代谢物信息卡片


(3S,8S,9S,10R,13R,14S,17R)-17-((2R,5R)-5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

化学式: C29H50O (414.3861)
中文名称: β-谷甾醇 (purity>98\\%), 谷甾醇 (purity>98\\%), 麦固醇 (purity>98\\%), 谷固醇 (purity>98\\%), β-谷甾醇, 谷固醇, 麦固醇, 谷甾醇, beta-谷甾醇
谱图信息: 最多检出来源 Homo sapiens(blood) 19.89%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@]([H])([C@]([H])(C)CC[C@@H](CC)C(C)C)CC[C@@]4([H])[C@]3([H])CC=C2C[C@@H](O)C1
InChI: InChI=1S/C29H50O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h10,19-21,23-27,30H,7-9,11-18H2,1-6H3/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1

描述信息

beta-Sitosterol, a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Phytosterols are plant sterols found in foods such as oils, nuts, and vegetables. Phytosterols, in the same way as cholesterol, contain a double bond and are susceptible to oxidation, and are characterized by anti-carcinogenic and anti-atherogenic properties (PMID:13129445, 11432711). beta-Sitosterol is a phytopharmacological extract containing a mixture of phytosterols, with smaller amounts of other sterols, bonded with glucosides. These phytosterols are commonly derived from the South African star grass, Hypoxis rooperi, or from species of Pinus and Picea. The purported active constituent is termed beta-sitosterol. Additionally, the quantity of beta-sitosterol-beta-D-glucoside is often reported. Although the exact mechanism of action of beta-sitosterols is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Compared with placebo, beta-sitosterol improved urinary symptom scores and flow measures (PMID:10368239). A plant food-based diet modifies the serum beta-sitosterol concentration in hyperandrogenic postmenopausal women. This finding indicates that beta-sitosterol can be used as a biomarker of exposure in observational studies or as a compliance indicator in dietary intervention studies of cancer prevention (PMID:14652381). beta-Sitosterol induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells (PMID:12579296).
Sitosterol is a member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3. It has a role as a sterol methyltransferase inhibitor, an anticholesteremic drug, an antioxidant, a plant metabolite and a mouse metabolite. It is a 3beta-sterol, a stigmastane sterol, a 3beta-hydroxy-Delta(5)-steroid, a C29-steroid and a member of phytosterols. It derives from a hydride of a stigmastane.
Active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.
Beta-Sitosterol is a natural product found in Elodea canadensis, Ophiopogon intermedius, and other organisms with data available.
beta-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. Sitosterols are white, waxy powders with a characteristic odor. They are hydrophobic and soluble in alcohols. beta-Sitosterol is found in many foods, some of which are ginseng, globe artichoke, sesbania flower, and common oregano.
C1907 - Drug, Natural Product > C28178 - Phytosterol > C68437 - Unsaturated Phytosterol
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
Beta-Sitosterol (purity>98\\%) is a plant sterol. Beta-Sitosterol (purity>98\\%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation[1].
Beta-Sitosterol (purity>98\%) is a plant sterol. Beta-Sitosterol (purity>98\%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation[1].

同义名列表

164 个代谢物同义名

(3S,8S,9S,10R,13R,14S,17R)-17-((2R,5R)-5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,9S,10R,13R,14S,17R)-17-((2R,5R)-5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,8S,9S,10R,13R,14S,17R)-17-[(1R,4R)-4-ethyl-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; beta-SITOSTEROL (CONSTITUENT OF ECHINACEA ANGUSTIFOLIA ROOT, ECHINACEA PALLIDA ROOT, ECHINACEA PURPUREA ROOT AND ECHINACEA PURPUREA AERIAL PARTS); (1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol; 14-((1S,4R)-4-ethyl-1,5-dimethylhexyl)(1S,5S,10S,11S,2R,14R,15R)-2,15-dimethyl tetracyclo[8.7.0.0<2,7>.0<11,15>]heptadec-7-en-5-ol; 17-(5-ethyl-6-methyl-heptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; beta-Sitosterol, United States Pharmacopeia (USP) Reference Standard; -Sitosterol (purity>98\\%);22,23-Dihydrostigmasterol (purity>98\\%); Beta-sitosterol, European Pharmacopoeia (EP) Reference Standard; beta-Sitosterol, primary pharmaceutical reference standard; beta-Sitosterol, analytical standard, from soybean, >=40\\%; BETA-SITOSTEROL, inverted exclamation markY 98\\% (HPLC); BETA-SITOSTEROL (CONSTITUENT OF STINGING NETTLE) [DSC]; Corn sterilized quantitative extract (beta sitosterol); BETA-SITOSTEROL (CONSTITUENT OF SAW PALMETTO) [DSC]; alpha-Dihydrofucosterol, 22,23-Dihydrostigmasterol; 24.BETA.-ETHYL-.DELTA.(SUP 5)-CHOLESTEN-3.BETA.-OL; BETA-SITOSTEROL (CONSTITUENT OF STINGING NETTLE); .BETA.-SITOSTEROL (CONSTITUENT OF PYGEUM) [DSC]; BETA-SITOSTEROL (CONSTITUENT OF SAW PALMETTO); 24beta-ETHYL-delta(SUP 5)-CHOLESTEN-3beta-OL; beta-SITOSTEROL (CONSTITUENT OF PYGEUM); beta-Sitosterol, from soybean, >=96\\%; beta-Sitosterol, analytical standard; .DELTA.(SUP 5)-STIGMASTEN-3.BETA.-OL; beta-Sitosterol, synthetic, >=95\\%; delta(SUP 5)-STIGMASTEN-3beta-OL; stigmast-5-en-3-ol, (3beta,24S)-; (24R)-Ethylcholest-5-en-3beta-ol; 24-Ethylcholest-5-en-3.beta.-ol; sitosterol, (3beta,24xi)-isomer; Stigmast-5-en-3-ol, (3.beta.)-; 24-ethylcholest-5-en-3 beta-ol; Beta-Sitosterol (purity>80\\%); Beta-Sitosterol (purity>75\\%); (24R)-Ethylcholest-5-en-3β-ol; Beta-Sitosterol (purity>98\\%); (24R)-Ethylcholest-5-en-3b-ol; (24R)-Stigmast-5-en-3beta-ol; (3.BETA.)-STIGMAST-5-EN-3-OL; sitosterol, 26-(14)C-labeled; Stigmasterol, 22,23-dihydro-; BETA-SITOSTEROL, 40\\% (HPLC); Stigmast-5-en-3-ol, (3beta)-; delta5-Stigmasten-3-beta-ol; KZJWDPNRJALLNS-VJSFXXLFSA-N; (3-beta)-Stigmast-5-en-3-ol; 24.alpha.-Ethylcholesterol; 22,23-dihydro-Stigmasterol; (3beta)-Stigmast-5-en-3-ol; sitosterol, (3beta)-isomer; delta5-Stigmasten-3beta-ol; Stigmast-5-en-3-ol, (3b)-; .alpha.-Dihydrofucosterol; (24R)-Stigmast-5-en-3β-ol; 5-cholesten-24-ethyl-3-ol; (24R)-Stigmast-5-en-3b-ol; 3 beta-stigmast-5-en-3-ol; 24-alpha-Ethylcholesterol; 22,23-Dihydrostigmasterol; BETA-SITOSTEROL (USP-RS); 24alpha-Ethylcholesterol; Stigmasterol,23-dihydro-; Stigmast-5-en-3.beta.-ol; 3beta-stigmast-5-en-3-ol; BETA-SITOSTEROL [USP-RS]; Beta-sitosterol [WHO-DD]; beta-Sitosterol, >=70\\%; Stigmast-5-en-3-beta-ol; Delta5-Stigmasten-3b-ol; alpha-Dihydrofucosterol; (3Β)-stigmast-5-en-3-ol; BETA SITOSTEROL [VANDF]; alpha.Dihydrofucosterol; (3b)-Stigmast-5-en-3-ol; .BETA.-SITOSTEROL [MI]; Stigmast-5-en-3beta-ol; BETA-SITOSTEROL [INCI]; Δ5-stigmasten-3beta-ol; 24Α-ethylcholesterol; 24a-Ethylcholesterol; Δ5-stigmasten-3β-ol; (-)-beta-Sitosterol; Angelicin (steroid); D5-Stigmasten-3b-ol; Stigmast-5-en-3b-ol; Α-dihydrofucosterol; 24-ethylcholesterol; .alpha.-Phytosterol; Stigmast-5-en-3β-ol; a-Dihydrofucosterol; Stigmast-5-en-3-ol; SITOSTEROL (MART.); SITOSTEROL [MART.]; Sitosterol, .beta.; Prestwick2_000985; Beta-Sitosterol-2; Prestwick3_000985; Prestwick1_000985; .beta.-Sitosterol; alpha-Phytosterol; Prestwick0_000985; SITOSTEROL, BETA-; .beta.-Sitosterin; gamma-sitosterol; (-)-Β-sitosterol; beta-Phytosterol; Beta-sistosterol; .beta.Sitosterin; SITOSTEROL, BETA; 3beta-sitosterol; .beta.Sitosterol; beta -Sitosterol; (-)-b-Sitosterol; beta-Sitosterol; beta-Sitosterin; beta Sitosterol; Sitosterol beta; ss--Sitosterol; BPBio1_001155; I2-sitosterol; a-Phytosterol; Α-phytosterol; MEGxp0_001710; Β-sitosterol; clionasterol; Tox21_111514; Β-sitosterin; NCI60_041777; B-Sitosterol; ACon1_000287; b-Sitosterin; CAS-83-46-5; Nimbosterol; Harzol (TN); SMP1_000274; Phytosterol; sitosterol; sitosterin; Sito-Lande; Azuprostat; Triastonal; Quebrachol; Betaprost; Angelicin; Prostasal; AI3-26020; ST 29:1;O; Rhammol; Rhamnol; Sobatum; Cinchol; Cupreol; Harzol; 24β-Ethylcholesterol; α-Dihydrofucosterol; 5-Stigmasten-3β-ol; β-Sitosterol; β-Sitosterol (purity>98\%); 22,23-Dihydrostigmasterol (purity>98\%); Beta-Sitosterol (purity>98\%); beta-Sitosterol



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

11 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(1)

  • Steroid Biosynthesis: Hydrogen Ion + Lathosterol + Oxygen + ferrocytochrome b5 ⟶ 7-Dehydrocholesterol + Water + ferricytochrome b5

PharmGKB(0)

2114 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, APOB, BCL2, CASP3, CASP9, CDKN1A, MAPK8, PIK3CA, PRKAA2, TP53, VEGFA
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 6 ABCA1, APOB, BCL2, CYP7A1, FDFT1, HMGCR
Nucleus 9 AKT1, BCL2, CASP3, CASP9, CDKN1A, MAPK8, PRKAA2, TP53, VEGFA
cytosol 11 AKT1, APOB, BCL2, CASP3, CASP9, CDKN1A, GPT, MAPK8, PIK3CA, PRKAA2, TP53
dendrite 1 PRKAA2
nuclear body 1 CDKN1A
phagocytic vesicle 1 ABCA1
centrosome 1 TP53
nucleoplasm 6 AKT1, CASP3, CDKN1A, MAPK8, PRKAA2, TP53
Cell membrane 5 ABCA1, ABCG5, ABCG8, AKT1, NPC1L1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 6 ABCA1, ABCG5, ABCG8, FDFT1, HMGCR, NPC1L1
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 3 ABCA1, PRKAA2, VEGFA
neuronal cell body 3 APOB, CASP3, PRKAA2
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 APOB
endosome 1 ABCA1
plasma membrane 7 ABCA1, ABCG5, ABCG8, AKT1, APOB, NPC1L1, PIK3CA
Membrane 11 ABCA1, ABCG5, ABCG8, AKT1, BCL2, FDFT1, HMGCR, NPC1L1, PRKAA2, TP53, VEGFA
apical plasma membrane 3 ABCG5, ABCG8, NPC1L1
axon 2 MAPK8, PRKAA2
basolateral plasma membrane 1 ABCA1
extracellular exosome 2 APOB, GPT
endoplasmic reticulum 5 BCL2, FDFT1, HMGCR, TP53, VEGFA
extracellular space 3 APOB, IL4, VEGFA
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 3 ABCA1, CDKN1A, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CASP9, TP53
protein-containing complex 5 AKT1, BCL2, CASP9, CDKN1A, TP53
intracellular membrane-bounded organelle 3 ABCA1, APOB, CYP7A1
Microsome membrane 1 CYP7A1
postsynaptic density 1 CASP3
Secreted 3 APOB, IL4, VEGFA
extracellular region 3 APOB, IL4, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYP7A1
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ABCA1
Secreted, extracellular space, extracellular matrix 1 VEGFA
chylomicron 1 APOB
low-density lipoprotein particle 1 APOB
very-low-density lipoprotein particle 1 APOB
microtubule cytoskeleton 1 AKT1
nucleolus 2 CDKN1A, TP53
Early endosome 1 APOB
cell-cell junction 1 AKT1
vesicle 1 AKT1
Apical cell membrane 3 ABCG5, ABCG8, NPC1L1
Membrane raft 1 ABCA1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
spindle 1 AKT1
extracellular matrix 1 VEGFA
intracellular vesicle 1 ABCA1
peroxisomal membrane 1 HMGCR
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 1 PRKAA2
receptor complex 2 ABCG5, ABCG8
ciliary basal body 1 AKT1
chromatin 1 TP53
brush border membrane 1 NPC1L1
site of double-strand break 1 TP53
Endomembrane system 1 NPC1L1
endosome lumen 1 APOB
Lipid droplet 1 APOB
Cytoplasmic vesicle membrane 1 NPC1L1
cytoplasmic stress granule 1 PRKAA2
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
endoplasmic reticulum lumen 1 APOB
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ABCA1
endoplasmic reticulum exit site 1 APOB
ATP-binding cassette (ABC) transporter complex 2 ABCG5, ABCG8
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 1 APOB
[Isoform 1]: Nucleus 1 TP53
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
endocytic vesicle lumen 1 APOB
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
mature chylomicron 1 APOB
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9


文献列表

  • Shujie Wang, Yuyue Qin, Yaping Liu, Guoqin Liu, Guiguang Cheng, Thanapop Soteyome. Controlling release of astaxanthin in β-sitosterol oleogel-based emulsions via different self-assembled mechanisms and composition of the oleogelators. Food research international (Ottawa, Ont.). 2024 Jun; 186(?):114350. doi: 10.1016/j.foodres.2024.114350. [PMID: 38729698]
  • Dan Zhang, Lulu Zhang, Chengwei Yuan, Kuizhi Zhai, Wansheng Xia, Yusui Duan, Bingnan Zhao, Jianzhou Chu, Xiaoqin Yao. Brassinolide as potential rescue agent for Pinellia ternata grown under microplastic condition: Insights into their modulatory role on photosynthesis, redox homeostasis, and AsA-GSH cycling. Journal of hazardous materials. 2024 May; 470(?):134116. doi: 10.1016/j.jhazmat.2024.134116. [PMID: 38547753]
  • Miriam Hollweck, David Jordan, Franz Bracher. Synthesis of a Side Chain Alkyne Analogue of Sitosterol as a Chemical Probe for Imaging in Plant Cells. Biomolecules. 2024 Apr; 14(5):. doi: 10.3390/biom14050542. [PMID: 38785949]
  • Shweta Jaiswal, Md Meraj Anjum, Dilip Kumar Arya, Sunita Thakur, Prashant Pandey, Payal Deepak, Shubham Kanaujiya, Sneha Anand, Arjun Singh Kaushik, Vikas Mishra, Paruvathanahalli Siddalingam Rajinikanth. Surface entrenched β-sitosterol niosomes for enhanced cardioprotective activity against isoproterenol induced cardiotoxicity in rats. International journal of pharmaceutics. 2024 Mar; 653(?):123872. doi: 10.1016/j.ijpharm.2024.123872. [PMID: 38336178]
  • Li-Huai Wang, Yin-Hui Sun, Hua Liu, Xiao Yang, Zhi Wen, Xue-Fei Tian. β-Sitosterol attenuates anlotinib resistance in non-small cell lung cancer cells by inhibiting miR-181a-3p/SHQ1 signaling. Chemical biology & drug design. 2024 03; 103(3):e14493. doi: 10.1111/cbdd.14493. [PMID: 38439529]
  • Yang Liu, Zenan Li, Weidong Li, Xuan Chen, Liping Yang, Shengli Lu, Shuai Zhou, Meng Li, Wu Xiong, Xi Zhang, Yu Liu, Jianda Zhou. Discovery of β-sitosterol's effects on molecular changes in rat diabetic wounds and its impact on angiogenesis and macrophages. International immunopharmacology. 2024 Jan; 126(?):111283. doi: 10.1016/j.intimp.2023.111283. [PMID: 38035407]
  • Quentin D'Arcy, Marissa Sarna-McCarthy, Delaney Bowen, Fidias O Soto, Kourosh Zarringhalam, Jill A Macoska. Beta-Sitosterol Alters Collagen Distribution in Prostate Fibroblasts. Journal of dietary supplements. 2024; 21(3):313-326. doi: 10.1080/19390211.2023.2276943. [PMID: 37933457]
  • Amita Mekarunothai, Markus Bacher, Raveevatoo Buathong, Saraphorn Intarasam, Ngampuk Tayana, Sumet Kongkiatpaiboon, Theppanya Charoenrat, Tiwtawat Napiroon. β-sitosterol isolated from the leaves of Trema orientalis (Cannabaceae) promotes viability and proliferation of BF-2 cells. PeerJ. 2024; 12(?):e16774. doi: 10.7717/peerj.16774. [PMID: 38282858]
  • Sara Zahid, Arif Malik, Suleyman Waqar, Fatima Zahid, Nusrat Tariq, Ali Imran Khawaja, Waqas Safir, Faisal Gulzar, Javeid Iqbal, Qurban Ali. Countenance and implication of Β-sitosterol, Β-amyrin and epiafzelechin in nickel exposed Rat: in-silico and in-vivo approach. Scientific reports. 2023 12; 13(1):21351. doi: 10.1038/s41598-023-48772-4. [PMID: 38049552]
  • Yachun Zheng, Jiaji Zhao, Shiquan Chang, Zifeng Zhuang, Si Waimei, Xin Li, Zenni Chen, Bei Jing, Di Zhang, Guoping Zhao. β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023 12; 18(4):690-703. doi: 10.1007/s11481-023-10091-w. [PMID: 38041701]
  • Zhongbiao Wu, Zhongyan Zhu, Liyuan Fu. Integrating GEO, network pharmacology, and in vitro assays to explore the pharmacological mechanism of Bruceae Fructus against laryngeal cancer. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Nov; ?(?):. doi: 10.1007/s00210-023-02869-9. [PMID: 38032489]
  • Sudeshna Nandi, Anish Nag, Somanjana Khatua, Surjit Sen, Nilanjan Chakraborty, Arghya Naskar, Krishnendu Acharya, Daniela Calina, Javad Sharifi-Rad. Anticancer activity and other biomedical properties of β-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches. Phytotherapy research : PTR. 2023 Nov; ?(?):. doi: 10.1002/ptr.8061. [PMID: 37929761]
  • Khadiga Alharbi, Amir Abdullah Khan, Haifa Abdulaziz Sakit Alhaithloul, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Saeedah Sallum Aloufi, Awatif M Abdulmajeed, Muhammad Atif Muneer, Suliman M S Alghanem, Muhammad Zia-Ur-Rehman, Muhammad Usman, Mona H Soliman. Synergistic effect of β-sitosterol and biochar application for improving plant growth of Thymus vulgaris under heat stress. Chemosphere. 2023 Nov; 340(?):139832. doi: 10.1016/j.chemosphere.2023.139832. [PMID: 37591372]
  • Yating Fan, Jinglin Shen, Xinlu Liu, Junhao Cui, Jiayi Liu, Dongqiao Peng, Yongcheng Jin. β-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914644. [PMID: 37834091]
  • Longkun Liu, Yoann Birling, Yan Zhao, Wenxin Ma, Yang Tang, Yuxin Sun, Xuehui Wang, Mingkun Yu, Hongsheng Bi, Jian-Ping Liu, Li Li, Zhaolan Liu. Mechanism of Chinese botanical drug Dizhi pill for myopia: An integrated study based on bioinformatics and network analysis. Medicine. 2023 Sep; 102(38):e34753. doi: 10.1097/md.0000000000034753. [PMID: 37747014]
  • Sahar Y Al-Okbi, Ola Ali, A S Aly, D Refaat, Reham S H Esmail, Hagar F H Elbakry. Management of metabolic syndrome by nutraceuticals prepared from chitosan and ferulic acid with or without beta-sitosterol and their nanoforms. Scientific reports. 2023 07; 13(1):12176. doi: 10.1038/s41598-023-38837-9. [PMID: 37500657]
  • Walaa E Hammam, Amany M Gad, Mary K Gad, Farid N Kirollos, Nemat A Yassin, Mona Elmahdy El Tantawi, Seham Salah Eldin El Hawary. Pyrus communis L. (Pear) and Malus domestica Borkh. (apple) leaves lipoidal extracts as sources for beta-sitosterol rich formulae and their wound healing evaluation. Natural product research. 2023 Jul; 37(15):2613-2617. doi: 10.1080/14786419.2022.2056181. [PMID: 35369826]
  • Haoyu Wang, Zhi Wang, Zihui Zhang, Jingchun Liu, Li Hong. Beta-sitosterol as a promising anticancer agent for chemoprevention and chemotherapy: mechanisms of action and future prospects. Advances in nutrition (Bethesda, Md.). 2023 May; ?(?):. doi: 10.1016/j.advnut.2023.05.013. [PMID: 37247842]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Omayma Ar Abo-Zaid, Fatma Sm Moawed, Effet Soliman Ismail, Mostafa A Farrag. β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway. BMC pharmacology & toxicology. 2023 05; 24(1):31. doi: 10.1186/s40360-023-00671-0. [PMID: 37173727]
  • Shengliang Gu, Fahui Liu, Xueheng Xie, Meng Ding, Zhen Wang, Xiaoyan Xing, Tianbao Xiao, Xiaobo Sun. β-Sitosterol blocks the LEF-1-mediated Wnt/β-catenin pathway to inhibit proliferation of human colon cancer cells. Cellular signalling. 2023 Apr; 104(?):110585. doi: 10.1016/j.cellsig.2022.110585. [PMID: 36603684]
  • Ahmed Jibrin Uttu, Muhammad Sani Sallau, Hamisu Ibrahim, Ogunkemi Risikat Agbeke Iyun. In silico modelling and NMR Characterization of some steroids from Strychnos innocua (Delile) root bark as potential antifungal agents. Steroids. 2023 Mar; 194(?):109222. doi: 10.1016/j.steroids.2023.109222. [PMID: 36924816]
  • Brice Maxime Nkouayeb Nangmou, Hermine Laure Maza Djomkam, Georges Bellier Tabekoueng, Willifred Dongmo Tékapi Tsopgni, Gabin Thierry Mbahbou Bitchagno, Michel Arnaud Mbock, Raceline Gounoue Kamkumo, Marcel Frese, Bruno Ndjakou Lenta, Silvère Augustin Ngouela, Nobert Sewald, Anatole Guy Blaise Azebaze. Bioguided Fractionation and Isolation of an Antiplasmodial Saponin from the Roots of Nauclea xanthoxylon (A.Chev.) Aubrév. (Rubiaceae). Chemistry & biodiversity. 2023 Mar; ?(?):e202200271. doi: 10.1002/cbdv.202200271. [PMID: 36890112]
  • Lokesh Ravi, Shabari Girish, Sharun Roy D'Souza, Anirudh Sreenivas Bk, Shree Kumari Gr, Archana O, Ajith Kumar K, Reji Manjunathan. β-Sitosterol, a phytocompound from Parthenium hysterophorus, reveals anti-diabetic properties through α-Amylase inhibition: an in-silico and in-vitro analysis. Journal of biomolecular structure & dynamics. 2023 Mar; ?(?):1-12. doi: 10.1080/07391102.2023.2186703. [PMID: 36880668]
  • Christelle Lopez, Elisabeth David-Briand, Virginie Lollier, Cristelle Mériadec, Thomas Bizien, Javier Pérez, Franck Artzner. Solubilization of free β-sitosterol in milk sphingomyelin and polar lipid vesicles as carriers: Structural characterization of the membranes and sphingosome morphology. Food research international (Ottawa, Ont.). 2023 Mar; 165(?):112496. doi: 10.1016/j.foodres.2023.112496. [PMID: 36869506]
  • Omayma Ar Abo-Zaid, Fatma Sm Moawed, Effat Soliman Ismail, Esraa S A Ahmed. β-Sitosterol mitigates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced hepatic injury in γ-irradiated rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Feb; 172(?):113602. doi: 10.1016/j.fct.2023.113602. [PMID: 36610474]
  • Kousalya Prabahar, Ubaidulla Udhumansha, Nehal Elsherbiny, Mona Qushawy. Microneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia. Drug delivery. 2022 Dec; 29(1):3022-3034. doi: 10.1080/10717544.2022.2120927. [PMID: 36110028]
  • Zidan Khan, Nikhil Nath, Abdur Rauf, Talha Bin Emran, Saikat Mitra, Fahadul Islam, Deepak Chandran, Jackie Barua, Mayeen Uddin Khandaker, Abubakr M Idris, Polrat Wilairatana, Muthu Thiruvengadam. Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications. Chemico-biological interactions. 2022 Sep; 365(?):110117. doi: 10.1016/j.cbi.2022.110117. [PMID: 35995256]
  • Karunamoorthy Vasanth, Guha Chowdhury Minakshi, Karthick Velu, Tanu Priya, R Mohan Kumar, Ilango Kaliappan, Govind Prasad Dubey. Anti-adipogenic β-sitosterol and lupeol from Moringa oleifera suppress adipocyte differentiation through regulation of cell cycle progression. Journal of food biochemistry. 2022 08; 46(8):e14170. doi: 10.1111/jfbc.14170. [PMID: 35403718]
  • Sameh S Elhady, Elsayed A Ibrahim, Marwa S Goda, Mohamed S Nafie, Hanan Samir, Reem M Diri, Abdulrahman M Alahdal, Ama Kyeraa Thomford, Alaa El Gindy, Ghada M Hadad, Jihan M Badr, Reda F A Abdelhameed. GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea. Molecules (Basel, Switzerland). 2022 Jun; 27(13):. doi: 10.3390/molecules27134109. [PMID: 35807354]
  • N M Mkolo, O O Olaokun, P H King, I Janse van Rensburg, J N Eloff, V Naidoo. Verification of the folkloric and anecdotal antidiabetic effects of Hypoxis hemerocallidea (Fisch., C.A. Mey. & Avé-Lall) and isolated, β-sitosterol using early-stage type II spontaneous diabetic mutant BKS-Leprdb mice. BMC complementary medicine and therapies. 2022 Jun; 22(1):163. doi: 10.1186/s12906-022-03640-y. [PMID: 35725532]
  • Risyandi Anwar, Susi Sukmasari, Lilis Siti Aisyah, Faridia Puspita Lestari, Delia Ilfani, Yenny Febriani Yun, Pebrian Diki Prestya. Antimicrobial Activity of β-Sitosterol Isolated from Kalanchoe tomentosa Leaves Against Staphylococcus aureus and Klebsiella pneumonia. Pakistan journal of biological sciences : PJBS. 2022 Jun; 25(7):602-607. doi: 10.3923/pjbs.2022.602.607. [PMID: 36098166]
  • Wendoline Rosiles-Alanis, Alejandro Zamilpa, Rebeca García-Macedo, Miguel A Zavala-Sánchez, Sergio Hidalgo-Figueroa, Beatriz Mora-Ramiro, Rubén Román-Ramos, Samuel E Estrada-Soto, Julio C Almanza-Perez. 4-Hydroxybenzoic Acid and β-Sitosterol from Cucurbita ficifolia Act as Insulin Secretagogues, Peroxisome Proliferator-Activated Receptor-Gamma Agonists, and Liver Glycogen Storage Promoters: In Vivo, In Vitro, and In Silico Studies. Journal of medicinal food. 2022 Jun; 25(6):588-596. doi: 10.1089/jmf.2021.0071. [PMID: 35708636]
  • Nikhitha Lakshmi, Ameer Basha Shaik, Pragya Paramita Pal, Sajeli Begum Ahil, Ramya Vittal, Saida Naik, Uma Devi Gali, Vidya Sagar Bokka. Piperine, Reserpine and β-Sitosterol Attenuate Stem Rot (Sclerotium rolfsii Sacc.) of Groundnut by Inducing the Secretion of defense Enzymes and Phenolic Acids. Chemistry & biodiversity. 2022 Apr; 19(4):e202100880. doi: 10.1002/cbdv.202100880. [PMID: 35182415]
  • S Baumgartner, D Lütjohann, C Husche, A Kerksiek, A K Groen, R P Mensink, J Plat. Plasma oxyphytosterols most likely originate from hepatic oxidation and subsequent spill-over in the circulation. The Journal of steroid biochemistry and molecular biology. 2022 02; 216(?):106039. doi: 10.1016/j.jsbmb.2021.106039. [PMID: 34861389]
  • Yuanyuan Hu, Jinwei Suo, Guoxiang Jiang, Jiayi Shen, Hao Cheng, Heqiang Lou, Weiwu Yu, Jiasheng Wu, Lili Song. The effect of ethylene on squalene and β-sitosterol biosynthesis and its key gene network analysis in Torreya grandis nuts during post-ripening process. Food chemistry. 2022 Jan; 368(?):130819. doi: 10.1016/j.foodchem.2021.130819. [PMID: 34411865]
  • Fan Ping, Yanxia Wang, Xia Shen, Conge Tan, Lin Zhu, Wenwen Xing, Jun Xu. Virtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Coronavirus Infection. Medical science monitor : international medical journal of experimental and clinical research. 2022 Jan; 28(?):e934102. doi: 10.12659/msm.934102. [PMID: 35075100]
  • Giau Van Vo, Paul C Guest, Thuy Trang Nguyen, Tuong Kha Vo. Evaluation of Anti-Hepatocellular-Cancer Properties of β-Sitosterol and β-Sitosterol-Glucoside from Indigofera zollingeriana Miq. Methods in molecular biology (Clifton, N.J.). 2022; 2343(?):229-240. doi: 10.1007/978-1-0716-1558-4_15. [PMID: 34473326]
  • Shumiao He, Siqing He, Yuankun Chen, Xiaobao Jin, Wenjie Mei, Qun Lu. Beta-Sitosterol Modulates the Migration of Vascular Smooth Muscle Cells via the PPARG/AMPK/mTOR Pathway. Pharmacology. 2022; 107(9-10):495-509. doi: 10.1159/000525218. [PMID: 35679828]
  • Madlen Reinicke, Judith Leyh, Silke Zimmermann, Soroth Chey, Ilijana Begcevic Brkovic, Christin Wassermann, Julia Landmann, Dieter Lütjohann, Berend Isermann, Ingo Bechmann, Uta Ceglarek. Plant Sterol-Poor Diet Is Associated with Pro-Inflammatory Lipid Mediators in the Murine Brain. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413207. [PMID: 34948003]
  • Salman S Alharthi, Ahmed Noah Badr, Karolina Gromadzka, Kinga Stuper-Szablewska, Adel Gabr Abdel-Razek, Khaled Selim. Bioactive Molecules of Mandarin Seed Oils Diminish Mycotoxin and the Existence of Fungi. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237130. [PMID: 34885712]
  • Niti Sharma, Mario A Tan, Seong Soo A An. Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212255. [PMID: 34830148]
  • Yunliang Dai, Kyung Ho Row. Imidazole-modified C6 -chitosan derivatives used to extract β-sitosterol from edible oil samples with a microwave-assisted solid phase extraction method. Journal of separation science. 2021 Nov; 44(21):3924-3932. doi: 10.1002/jssc.202100503. [PMID: 34459118]
  • Lokadi Pierre Luhata, Toyonobu Usuki. Antibacterial activity of β-sitosterol isolated from the leaves of Odontonema strictum (Acanthaceae). Bioorganic & medicinal chemistry letters. 2021 09; 48(?):128248. doi: 10.1016/j.bmcl.2021.128248. [PMID: 34252548]
  • Zühre Kaya, Ertan Sal, Aslı Yorulmaz, Yu-Ping Hsieh, Hüseyin Gülen, Ayşen Türedi Yıldırım, Dau-Ming Niu, Aziz Tekin. Genetic basis and hematologic manifestations of sitosterolemia in a group of Turkish patients. Journal of clinical lipidology. 2021 Sep; 15(5):690-698. doi: 10.1016/j.jacl.2021.07.001. [PMID: 34304999]
  • Fabio Ferrini, Daniele Fraternale, Sabrina Donati Zeppa, Giancarlo Verardo, Andrea Gorassini, Vittoria Carrabs, Maria Cristina Albertini, Piero Sestili. Yield, Characterization, and Possible Exploitation of Cannabis Sativa L. Roots Grown under Aeroponics Cultivation. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164889. [PMID: 34443479]
  • Kajal Chakraborty, Minju Joy, Vamshi Krishna Raola. Anti-inflammatory β-sitosterols from the Asiatic loop-root mangrove Rhizophora mucronata attenuate 5-lipoxygenase and cyclooxygenase-2 enzymes. Steroids. 2021 08; 172(?):108860. doi: 10.1016/j.steroids.2021.108860. [PMID: 33971207]
  • Chaoying Qiu, Mengting Lei, Wan Jun Lee, Ning Zhang, Yong Wang. Fabrication and characterization of stable oleofoam based on medium-long chain diacylglycerol and β-sitosterol. Food chemistry. 2021 Jul; 350(?):129275. doi: 10.1016/j.foodchem.2021.129275. [PMID: 33601090]
  • Wenge Zhang, Xiuxiang Lu, Luqiong Huo, Sha Zhang, Yan Chen, Zhenxing Zou, Haibo Tan. Sesquiterpenes and Steroids from an Endophytic Eutypella scoparia. Journal of natural products. 2021 06; 84(6):1715-1724. doi: 10.1021/acs.jnatprod.0c01167. [PMID: 34033486]
  • Yingying Shi, Dongdong Zhang, Shupei Li, Xiuxiu Xuan, Liuqiang Zhang, Yiming Li, Fujiang Guo. Inhibitors of BRD4 protein from the roots of Astilbe grandis stapf ex E.H. Wilson. Natural product research. 2021 Jun; 35(12):2044-2050. doi: 10.1080/14786419.2019.1655414. [PMID: 31437007]
  • Veena S Patel, Usmangani K Chhalotiya, Sandip B Patel, Jivani Nuruddin. Simultaneous Quantification of Betulinic Acid, Lupeol, and β-Sitosterol in Madhuca longifolia Methanolic Extract of Bark by Liquid Chromatography-Tandem Mass Spectrometric Method. Journal of AOAC International. 2021 May; 104(2):498-505. doi: 10.1093/jaoacint/qsaa128. [PMID: 33615381]
  • Selvaraj Jayaraman, Nalini Devarajan, Ponnulakshmi Rajagopal, Shyamaladevi Babu, Senthil Kumar Ganesan, Vishnu Priya Veeraraghavan, Chella Perumal Palanisamy, Bo Cui, Vijayalakshmi Periyasamy, Kirubhanand Chandrasekar. β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats. Molecules (Basel, Switzerland). 2021 Apr; 26(7):. doi: 10.3390/molecules26072101. [PMID: 33917607]
  • Abdullahi Shehu, Mangala Gowri Ponnapalli, M Mahboob, P V Prabhakar, Gabriel Ademola Olatunji. New n-nonadecanoyl-β-sitosterol and other constituents from the stem-bark of Anacardium occidentale. Natural product research. 2021 Apr; 35(8):1357-1363. doi: 10.1080/14786419.2019.1650353. [PMID: 31397595]
  • Wen-Chin Lee, Wei-Hung Kuo, Sin-Hua Moi, Barry Chiu, Jin-Bor Chen, Cheng-Hong Yang. Associations between Circulating Markers of Cholesterol Homeostasis and Macrovascular Events among Patients Undergoing Hemodialysis. Nutrients. 2021 Mar; 13(3):. doi: 10.3390/nu13031014. [PMID: 33801029]
  • Kubra Koc, Fatime Geyikoglu, Ozge Cakmak, Aynur Koca, Zerrin Kutlu, Ferhunde Aysin, Asli Yilmaz, Hakan Aşkın. The targets of β-sitosterol as a novel therapeutic against cardio-renal complications in acute renal ischemia/reperfusion damage. Naunyn-Schmiedeberg's archives of pharmacology. 2021 03; 394(3):469-479. doi: 10.1007/s00210-020-01984-1. [PMID: 33048170]
  • Yusha'u Shu'aibu Baraya, Hassan Muhammad Yankuzo, Kah Keng Wong, Nik Soriani Yaacob. Strobilanthes crispus bioactive subfraction inhibits tumor progression and improves hematological and morphological parameters in mouse mammary carcinoma model. Journal of ethnopharmacology. 2021 Mar; 267(?):113522. doi: 10.1016/j.jep.2020.113522. [PMID: 33127562]
  • Sławomira Drzymała-Czyż, Patrycja Krzyżanowska-Jankowska, Krzysztof Dziedzic, Aleksandra Lisowska, Szymon Kurek, Joanna Goździk-Spychalska, Victoria Kononets, Dagmara Woźniak, Edyta Mądry, Jarosław Walkowiak. Severe Genotype, Pancreatic Insufficiency and Low Dose of Pancreatic Enzymes Associate with Abnormal Serum Sterol Profile in Cystic Fibrosis. Biomolecules. 2021 02; 11(2):. doi: 10.3390/biom11020313. [PMID: 33669566]
  • Acharya Balkrishna, Pradeep Nain, Monali Joshi, Lakshmipathi Khandrika, Anurag Varshney. Supercritical Fluid Extract of Putranjiva roxburghii Wall. Seeds Mitigates Fertility Impairment in a Zebrafish Model. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26041020. [PMID: 33672019]
  • Xue Bai, Yibo Tang, Qiang Li, Yafei Chen, Dan Liu, Guimin Liu, Xiaolei Fan, Ru Ma, Shuyan Wang, Lingru Li, Kailin Zhou, Yanfei Zheng, Zhenquan Liu. Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis-Lycium barbarum coupled-herbs against oligoasthenozoospermia. Scientific reports. 2021 01; 11(1):2220. doi: 10.1038/s41598-020-80780-6. [PMID: 33500463]
  • Graziana Difonzo, Antonella Aresta, Pietro Cotugno, Roberta Ragni, Giacomo Squeo, Carmine Summo, Federica Massari, Antonella Pasqualone, Michele Faccia, Carlo Zambonin, Francesco Caponio. Supercritical CO2 Extraction of Phytocompounds from Olive Pomace Subjected to Different Drying Methods. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030598. [PMID: 33498727]
  • Hui-Fen Shen, Ying Liu, Ping-Ping Qu, Yu Tang, Bing-Bing Li, Guo-Liang Cheng. MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in γ-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease. International journal of chronic obstructive pulmonary disease. 2021 ; 16(?):2741-2753. doi: 10.2147/copd.s326015. [PMID: 34675500]
  • Dan He, Qiang Li, Guangli Du, Jijia Sun, Guofeng Meng, Shaoli Chen. Research on the Mechanism of Guizhi to Treat Nephrotic Syndrome Based on Network Pharmacology and Molecular Docking Technology. BioMed research international. 2021; 2021(?):8141075. doi: 10.1155/2021/8141075. [PMID: 34873575]
  • Sahar Nasim, Mohib Shah, Syed Wadood Ali Shah, Muhammad Naeem Ahmed, Mubashir Ahmad, Natasha Anwar, Mehreen Ghias. Activity guided isolation and mechanistic approach towards analgesic potential of Chenopodium mediated through opioidergic pathway. Pakistan journal of pharmaceutical sciences. 2021 Jan; 34(1(Supplementary)):197-203. doi: ". [PMID: 34275843]
  • Takeo Yamaguchi, Chiharu Manaka, Ayaka Ogura, Shigemi Nagadome. Importance of Cholesterol Side Chain in the Membrane Stability of Human Erythrocytes. Biological & pharmaceutical bulletin. 2021; 44(6):888-893. doi: 10.1248/bpb.b21-00134. [PMID: 34078822]
  • Sara Kasirzadeh, Mohammad Hossein Ghahremani, Neda Setayesh, Fereshteh Jeivad, Amir Shadboorestan, Ali Taheri, Abbas Beh-Pajooh, Armin Azadkhah Shalmani, Alireza Ebadollahi-Natanzi, Alamgir Khan, Samin Sabzevari, Omid Sabzevari. β-Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling. BioMed research international. 2021; 2021(?):5535562. doi: 10.1155/2021/5535562. [PMID: 33997001]
  • Martha Valdivia, Percy Soto-Becerra, Ricardo Laguna-Barraza, Percy A Rojas, Ivonne Reyes-Mandujano, Paola Gonzáles-Reyes, Haydee Temoche, Olga S Timoteo, Gabriela Lugo-Martinez, Claudia C Calzada-Mendoza, Edward Mezones-Holguin. Effect of a natural supplement containing glucosinolates, phytosterols and citrus flavonoids on body weight and metabolic parameters in a menopausal murine model induced by bilateral ovariectomy. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2020 Dec; 36(12):1106-1111. doi: 10.1080/09513590.2020.1821639. [PMID: 32954883]
  • Feng Zhang, Zhiyu Liu, Xijing He, Zhanqi Li, Bin Shi, Fengmei Cai. β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway. Drug delivery. 2020 Dec; 27(1):1329-1341. doi: 10.1080/10717544.2020.1818883. [PMID: 32945205]
  • Yujiro Nakano, Chikara Komiya, Hitomi Shimizu, Hiroyuki Mishima, Kumiko Shiba, Kazutaka Tsujimoto, Kenji Ikeda, Kenichi Kashimada, Sumito Dateki, Koh-Ichiro Yoshiura, Yoshihiro Ogawa, Tetsuya Yamada. A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in ABCG5. Endocrine journal. 2020 Nov; 67(11):1099-1105. doi: 10.1507/endocrj.ej20-0044. [PMID: 32641618]
  • Pijush Kanti Pramanik, Sajal Chakraborti, Angshuman Bagchi, Tapati Chakraborti. Bioassay-based Corchorus capsularis L. leaf-derived β-sitosterol exerts antileishmanial effects against Leishmania donovani by targeting trypanothione reductase. Scientific reports. 2020 11; 10(1):20440. doi: 10.1038/s41598-020-77066-2. [PMID: 33235245]
  • Lulu Dong, Muwen Lv, Xiangyang Gao, Luping Zhang, Michael Rogers, Yong Cao, Yaqi Lan. In vitro gastrointestinal digestibility of phytosterol oleogels: influence of self-assembled microstructures on emulsification efficiency and lipase activity. Food & function. 2020 Nov; 11(11):9503-9513. doi: 10.1039/d0fo01642j. [PMID: 32955534]
  • Zhenjuan Chen, Ancheng Wu, Hongmei Jin, Fuhui Liu. β-Sitosterol attenuates liver injury in a rat model of chronic alcohol intake. Archives of pharmacal research. 2020 Nov; 43(11):1197-1206. doi: 10.1007/s12272-020-01271-w. [PMID: 33155166]
  • Shyamaladevi Babu, Selvaraj Jayaraman. An update on β-sitosterol: A potential herbal nutraceutical for diabetic management. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov; 131(?):110702. doi: 10.1016/j.biopha.2020.110702. [PMID: 32882583]
  • Hamid Rashidi Nodeh, Ladan Rashidi, Mohammad Ali Gabris, Zahra Gholami, Syed Shahabuddin, Nanthini Sridewi. Chemical and Physical Characterization of the Hackberry (Celtis australis) Seed Oil: Analysis of Tocopherols, Sterols, ECN and Fatty Acid Methyl Esters. Journal of oleo science. 2020 Nov; 69(11):1359-1366. doi: 10.5650/jos.ess20128. [PMID: 33055442]
  • Beibei Zhao, Yan Zhang, Hua Li, Jiawen Deng, Haodi Gong, Zhicheng Chen. Nutritional Component and Chemical Characterization of Chinese Highland Barley Bran Oil. Journal of oleo science. 2020 Nov; 69(11):1339-1347. doi: 10.5650/jos.ess19318. [PMID: 33055435]
  • Ivana Semova, Amy E Levenson, Joanna Krawczyk, Kevin Bullock, Kathryn A Williams, R Paul Wadwa, Philip R Khoury, Thomas R Kimball, Elaine M Urbina, Sarah D de Ferranti, David M Maahs, Lawrence M Dolan, Amy S Shah, Clary B Clish, Sudha B Biddinger. Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes. Pediatric diabetes. 2020 11; 21(7):1126-1131. doi: 10.1111/pedi.13097. [PMID: 32738021]
  • Abeer M El Sayed, Samar M Basam, El-Moataz Bellah A El-Naggar, Hanan S Marzouk, Seham El-Hawary. LC-MS/MS and GC-MS profiling as well as the antimicrobial effect of leaves of selected Yucca species introduced to Egypt. Scientific reports. 2020 10; 10(1):17778. doi: 10.1038/s41598-020-74440-y. [PMID: 33082381]
  • Takeru Koga, Takaiku Sakamoto, Eiji Sakuradani, Akihiro Tai. Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204748. [PMID: 33081156]
  • Akihiro Nomura, Connor A Emdin, Hong Hee Won, Gina M Peloso, Pradeep Natarajan, Diego Ardissino, John Danesh, Heribert Schunkert, Adolfo Correa, Matthew J Bown, Nilesh J Samani, Jeanette Erdmann, Ruth McPherson, Hugh Watkins, Danish Saleheen, Roberto Elosua, Masa-Aki Kawashiri, Hayato Tada, Namrata Gupta, Svati H Shah, Daniel J Rader, Stacey Gabriel, Amit V Khera, Sekar Kathiresan. Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease. Circulation. Genomic and precision medicine. 2020 10; 13(5):417-423. doi: 10.1161/circgen.119.002871. [PMID: 32862661]
  • Bei-Xian Zhou, Jing Li, Xiao-Li Liang, Xi-Ping Pan, Yan-Bing Hao, Pei-Fang Xie, Hai-Ming Jiang, Zi-Feng Yang, Nan-Shan Zhong. β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling. Acta pharmacologica Sinica. 2020 Sep; 41(9):1178-1196. doi: 10.1038/s41401-020-0403-9. [PMID: 32504068]
  • Shazia Anjum, Muhammad Asif, Kashaf Zia, Bakhat Jahan, Muhammad Ashraf, Shafqat Hussain, Muhammad Qasim Hayat, Muhammad Raza Shah, Muhammad Nawaz Tahir. Biological and phytochemical studies on Capparis decidua (Forssk) Edgew from Cholistan desert. Natural product research. 2020 Aug; 34(16):2315-2318. doi: 10.1080/14786419.2018.1531403. [PMID: 30587037]
  • Nobuko Kojima, Hayato Tada, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Atsushi Nohara, Akihiro Inazu, Masayuki Takamura, Masa-Aki Kawashiri. Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations. Clinica chimica acta; international journal of clinical chemistry. 2020 Aug; 507(?):11-16. doi: 10.1016/j.cca.2020.04.003. [PMID: 32275988]
  • Ranabir Majumder, Pratap Parida, Samrat Paul, Piyali Basak. In vitro and in silico study of Aloe vera leaf extract against human breast cancer. Natural product research. 2020 Aug; 34(16):2363-2366. doi: 10.1080/14786419.2018.1534848. [PMID: 30600703]
  • Qingqing Guo, Li Li, Kang Zheng, Guang Zheng, Haiyang Shu, Yingjie Shi, Cheng Lu, Jun Shu, Daogang Guan, Aiping Lu, Xiaojuan He. Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis. Journal of leukocyte biology. 2020 08; 108(2):509-517. doi: 10.1002/jlb.3ma0320-440rr. [PMID: 32392637]
  • Valéria Sutti Nunes, Isabela M Bensenor, Paulo A Lotufo, Marisa Passarelli, Edna Regina Nakandakare, Eder Carlos Rocha Quintão. The coronary artery calcium score is linked to plasma cholesterol synthesis and absorption markers: Brazilian Longitudinal Study of Adult Health. Bioscience reports. 2020 07; 40(7):. doi: 10.1042/bsr20201094. [PMID: 32579186]
  • H V Sudeep, Jestin V Thomas, K Shyamprasad. A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency. BMC urology. 2020 Jul; 20(1):86. doi: 10.1186/s12894-020-00648-9. [PMID: 32620155]
  • Fang Liu, Xiaoping Zhang, Mingdao Wang, Lele Guo, Yingyue Yang, Mingqin Zhao. Biosorption of sterols from tobacco waste extract using living and dead of newly isolated fungus Aspergillus fumigatus strain LSD-1. Bioscience, biotechnology, and biochemistry. 2020 Jul; 84(7):1521-1528. doi: 10.1080/09168451.2020.1742089. [PMID: 32183612]
  • Sonia Calligaris, Marilisa Alongi, Paolo Lucci, Monica Anese. Effect of different oleogelators on lipolysis and curcuminoid bioaccessibility upon in vitro digestion of sunflower oil oleogels. Food chemistry. 2020 Jun; 314(?):126146. doi: 10.1016/j.foodchem.2019.126146. [PMID: 31954944]
  • Ezhilarasan Devaraj, Anitha Roy, Geetha Royapuram Veeraragavan, Anitha Magesh, Aneymol Varikalam Sleeba, Lakshminarayanan Arivarasu, Brundha Marimuthu Parasuraman. β-Sitosterol attenuates carbon tetrachloride-induced oxidative stress and chronic liver injury in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2020 06; 393(6):1067-1075. doi: 10.1007/s00210-020-01810-8. [PMID: 31930431]
  • Adchara Prommaban, Niramon Utama-Ang, Anan Chaikitwattana, Chairat Uthaipibull, John B Porter, Somdet Srichairatanakool. Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil. Molecules (Basel, Switzerland). 2020 May; 25(11):. doi: 10.3390/molecules25112474. [PMID: 32471050]
  • Yan-Jie Qu, Rong-Rong Zhen, Li-Min Zhang, Chao Gu, Lei Chen, Xiao Peng, Bing Hu, Hong-Mei An. Uncovering the active compounds and effective mechanisms of the dried mature sarcocarp of Cornus officinalis Sieb. Et Zucc. For the treatment of Alzheimer's disease through a network pharmacology approach. BMC complementary medicine and therapies. 2020 May; 20(1):157. doi: 10.1186/s12906-020-02951-2. [PMID: 32450873]
  • Abdirahman Elmi, Rosella Spina, Arnaud Risler, Stéphanie Philippot, Ali Mérito, Raphaël E Duval, Fatouma Mohamed Abdoul-Latif, Dominique Laurain-Mattar. Evaluation of Antioxidant and Antibacterial Activities, Cytotoxicity of Acacia seyal Del Bark Extracts and Isolated Compounds. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102392. [PMID: 32455580]
  • Asmita Poudel, George Gachumi, Ildiko Badea, Zafer Dallal Bashi, Anas El-Aneed. The simultaneous quantification of phytosterols and tocopherols in liposomal formulations using validated atmospheric pressure chemical ionization- liquid chromatography -tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2020 May; 183(?):113104. doi: 10.1016/j.jpba.2020.113104. [PMID: 32058287]
  • Cathelijne Heymans, Lara R Heij, Kaatje Lenaerts, Marcel den Dulk, Mhamed Hadfoune, Chantal van Heugten, Owen B Spiller, Michael L Beeton, Sarah J Stock, Alan H Jobe, Matthew S Payne, Matthew W Kemp, Boris W Kramer, Jogchum Plat, Wim G van Gemert, Tim G A M Wolfs. Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep. Nutrients. 2020 May; 12(5):. doi: 10.3390/nu12051312. [PMID: 32380648]
  • Ivy W Chen, Robert J Grebenok, Hubert Schaller, Keyan Zhu-Salzman, Spencer T Behmer. Aphid growth and reproduction on plants with altered sterol profiles: Novel insights using Arabidopsis mutant and overexpression lines. Journal of insect physiology. 2020 May; 123(?):104054. doi: 10.1016/j.jinsphys.2020.104054. [PMID: 32275907]
  • Qin Deng, Gang Li, Mengyu Sun, Xiaobo Yang, Jing Xu. A new antimicrobial sesquiterpene isolated from endophytic fungus Cytospora sp. from the Chinese mangrove plant Ceriops tagal. Natural product research. 2020 May; 34(10):1404-1408. doi: 10.1080/14786419.2018.1512993. [PMID: 30417674]
  • Hiroshi Yoshida, Hayato Tada, Kumie Ito, Yoshimi Kishimoto, Hidekatsu Yanai, Tomonori Okamura, Katsunori Ikewaki, Kyoko Inagaki, Tetsuo Shoji, Hideaki Bujo, Takashi Miida, Masayuki Yoshida, Masafumi Kuzuya, Shizuya Yamashita. Reference Intervals of Serum Non-Cholesterol Sterols by Gender in Healthy Japanese Individuals. Journal of atherosclerosis and thrombosis. 2020 May; 27(5):409-417. doi: 10.5551/jat.50187. [PMID: 31484845]
  • Jetsada Ruangsuriya, Suporn Charumanee, Supat Jiranusornkul, Panee Sirisa-Ard, Busaban Sirithunyalug, Jakkapan Sirithunyalug, Thanawat Pattananandecha, Chalermpong Saenjum. Depletion of β-sitosterol and enrichment of quercetin and rutin in Cissus quadrangularis Linn fraction enhanced osteogenic but reduced osteoclastogenic marker expression. BMC complementary medicine and therapies. 2020 Apr; 20(1):105. doi: 10.1186/s12906-020-02892-w. [PMID: 32245457]
  • Nontobeko M Gumede, Busisani W Lembede, Richard L Brooksbank, Kennedy H Erlwanger, Eliton Chivandi. β-Sitosterol Shows Potential to Protect Against the Development of High-Fructose Diet-Induced Metabolic Dysfunction in Female Rats. Journal of medicinal food. 2020 Apr; 23(4):367-374. doi: 10.1089/jmf.2019.0120. [PMID: 31517568]
  • Claudia Aparecida Silva Almeida, Sueli Regina Baggio, Lilian Regina Barros Mariutti, Neura Bragagnolo. One-step rapid extraction of phytosterols from vegetable oils. Food research international (Ottawa, Ont.). 2020 04; 130(?):108891. doi: 10.1016/j.foodres.2019.108891. [PMID: 32156349]