Amyrin (BioDeep_00000000901)

 

Secondary id: BioDeep_00000259010

PANOMIX_OTCML-2023


代谢物信息卡片


(3S,4aR,5R,6aR,6bR,8S,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-Octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-eicosahydro-picen-3-ol

化学式: C30H50O (426.386145)
中文名称: beta-香树精, β-香树脂醇, β-香树素, beta-香树精
谱图信息: 最多检出来源 Bos taurus(endogenous) 2.7%

分子结构信息

SMILES: CC1(C)CCC2(C)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC43C)C2C1
InChI: InChI=1S/C30H50O/c1-25(2)15-16-27(5)17-18-29(7)20(21(27)19-25)9-10-23-28(6)13-12-24(31)26(3,4)22(28)11-14-30(23,29)8/h9,21-24,31H,10-19H2,1-8H3

描述信息

Beta-amyrin is a pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants. It has a role as a plant metabolite and an Aspergillus metabolite. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an oleanane.
beta-Amyrin is a natural product found in Ficus pertusa, Ficus septica, and other organisms with data available.
See also: Calendula Officinalis Flower (part of); Viburnum opulus bark (part of); Centaurium erythraea whole (part of).
A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.
β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1].
β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1].

同义名列表

36 个代谢物同义名

(3S,4aR,5R,6aR,6bR,8S,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-Octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-eicosahydro-picen-3-ol; (3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-ol; (3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol; beta-Amyrin, analytical standard; JFSHUTJDVKUMTJ-QHPUVITPSA-N; (3-.beta.)-Olean-12-en-3-ol; Olean-12-en-3-ol, (3beta)-; 3beta-hydroxyolean-12-ene; (3beta)-olean-12-en-3-ol; Olean-12-en-3-ol, (3b)-; Olean-12-en-3beta-ol; .BETA.-AMYRIN [MI]; beta.-Amyrenol; beta-Amyrenol; AMYRIN, BETA-; beta.-Amyrin; beta -Amyrin; I(2)-Amyrin; Beta-Amyrin; β-Amyrin; B-Amyrin; -amyrin; Amyrin; Olean-12-en-3-ol, (3beta)- (9CI); EINECS 209-204-6; LMPR01060012; AIDS-058054; 09236_FLUKA; AIDS058054; NSC 527971; ST5309409; 559-70-6; C08616; Olean-12-en-3β-ol; .beta.-Amyrin; β-Amyrin



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

42 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(9)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(33)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1334 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sara Zahid, Arif Malik, Suleyman Waqar, Fatima Zahid, Nusrat Tariq, Ali Imran Khawaja, Waqas Safir, Faisal Gulzar, Javeid Iqbal, Qurban Ali. Countenance and implication of Β-sitosterol, Β-amyrin and epiafzelechin in nickel exposed Rat: in-silico and in-vivo approach. Scientific reports. 2023 12; 13(1):21351. doi: 10.1038/s41598-023-48772-4. [PMID: 38049552]
  • Opeyemi Josephine Akinmurele, Mubo Adeola Sonibare, Anthony A Elujoba, Akingbolabo Daniel Ogunlakin, Oloruntoba Emmanuel Yeye, Gideon Ampoma Gyebi, Oluwafemi Adeleke Ojo, Abdullah R Alanzi. Antispasmodic Effect of Alstonia boonei De Wild. and Its Constituents: Ex Vivo and In Silico Approaches. Molecules (Basel, Switzerland). 2023 Oct; 28(20):. doi: 10.3390/molecules28207069. [PMID: 37894548]
  • Jinling Li, Shuai Wang, Yinan Miao, Ya Wan, Chun Li, Ying Wang. Mining and modification of Oryza sativa-derived squalene epoxidase for improved β-amyrin production in Saccharomyces cerevisiae. Journal of biotechnology. 2023 Aug; 375(?):1-11. doi: 10.1016/j.jbiotec.2023.08.004. [PMID: 37597655]
  • Mona Raslan, Marwa M Mounier. Phytochemical profiling and compound isolation of Cissus rhombifolia Vahl. leaves aqueous methanolic extract with the evaluation of its anti-inflammatory effect using lipopolysaccharide-induced inflammation in RAW 264.7 cells. Chemistry & biodiversity. 2023 May; ?(?):e202300307. doi: 10.1002/cbdv.202300307. [PMID: 37204915]
  • Han-Bin Choi, Sangrea Shim, Myeong-Hyeon Wang, Yong-Eui Choi. De Novo Transcriptome Sequencing of Codonopsis lanceolata for Identification of Triterpene Synthase and Triterpene Acetyltransferase. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065769. [PMID: 36982844]
  • Mengchu Sun, Qi Xin, Kangxin Hou, Jie Qiu, Linmei Wang, Erkun Chao, Xinyao Su, Xiuxin Zhang, Shilin Chen, Caixia Wang. Production of 11-Oxo-β-Amyrin in Saccharomyces cerevisiae at High Efficiency by Fine-Tuning the Expression Ratio of CYP450:CPR. Journal of agricultural and food chemistry. 2023 Feb; ?(?):. doi: 10.1021/acs.jafc.2c08261. [PMID: 36795896]
  • Ying Zhu, Chen Zhou, Xia Liu, Xinying Li, Caifang Shi, Yapeng Zhang, Ying Wang, Chun Li. Aided-efflux and high production of β-amyrin realized by β-cyclodextrin in situ synthesized on surface of Saccharomyces cerevisiae. Biotechnology and bioengineering. 2023 Jan; ?(?):. doi: 10.1002/bit.28327. [PMID: 36593696]
  • Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn, Xue Qiao. Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function. Journal of advanced research. 2023 01; 43(?):247-257. doi: 10.1016/j.jare.2022.03.014. [PMID: 36585112]
  • Hai-Yun Gao, Long-Long Gao, Yuan Liu, Huan Zhao, Wei Gao. [Cloning and functional characterization of two oxidosqualene cyclase genes from Siraitia grosvenorii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Nov; 47(22):6050-6057. doi: 10.19540/j.cnki.cjcmm.20220713.102. [PMID: 36471929]
  • Md Amjad Beg, Shivangi, Obaid Afzal, Md Sayeed Akhtar, Abdulmalik S A Altamimi, Afzal Hussain, Md Ali Imam, Mohammad Naiyaz Ahmad, Sidharth Chopra, Fareeda Athar. Potential Efficacy of β-Amyrin Targeting Mycobacterial Universal Stress Protein by In Vitro and In Silico Approach. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144581. [PMID: 35889451]
  • Wenhua Xu, Hongwu Zhang, Qinfeng Zhang, Jialan Xu. β-Amyrin ameliorates diabetic nephropathy in mice and regulates the miR-181b-5p/HMGB2 axis in high glucose-stimulated HK-2 cells. Environmental toxicology. 2022 Mar; 37(3):637-649. doi: 10.1002/tox.23431. [PMID: 34894065]
  • Tran Duc Viet, Tran Dang Xuan, La Hoang Anh. α-Amyrin and β-Amyrin Isolated from Celastrus hindsii Leaves and Their Antioxidant, Anti-Xanthine Oxidase, and Anti-Tyrosinase Potentials. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237248. [PMID: 34885832]
  • Bruna F Mazzeu, Tatiana M Souza-Moreira, Andrew A Oliveira, Melissa Remlinger, Lidiane G Felippe, Sandro R Valentini, Rafael V C Guido, Cleslei F Zanelli, Maysa Furlan. The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226806. [PMID: 34833897]
  • Do Tien Lam, Vu Thi Thu Le, Pham Minh Quan, Pham Thi Hong Minh, Ta Thi Thu Thuy, Nguyen Thi Ngoc Anh, Bui Huu Tai, Phan Van Kiem. Two new terpenoids from the leaves of callicarpa macrophylla. Natural product research. 2021 Apr; 35(7):1107-1114. doi: 10.1080/14786419.2019.1639180. [PMID: 31303054]
  • Nan Qin, Xin Lu, Yijun Liu, Yuting Qiao, Wei Qu, Feng Feng, Haopeng Sun. Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry. European journal of medicinal chemistry. 2021 Jan; 210(?):112960. doi: 10.1016/j.ejmech.2020.112960. [PMID: 33148492]
  • R P de Lima, P I G Nunes, A F S C Viana, F T B de Oliveira, R A C Silva, A P N N Alves, D A Viana, S G C Fonseca, A A Carvalho, M H Chaves, V S Rao, F A Santos. α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2021; 54(10):e11391. doi: 10.1590/1414-431x2021e11391. [PMID: 34406209]
  • Feilong Chen, Dong-Li Liu, Wei Wang, Xiao-Man Lv, Weixi Li, Li-Dong Shao, Wen-Jing Wang. Bioactive triterpenoids from Sambucus javanica Blume. Natural product research. 2020 Oct; 34(19):2816-2821. doi: 10.1080/14786419.2019.1596092. [PMID: 30968700]
  • Jian Wang, Hui-Xin Lin, Huan Zhao, Juan Guo, Ping Su, Jian Yang, Xiao-Yi Wu, Lu-Qi Huang, Wei Gao. Molecular cloning and functional characterization of multiple ApOSCs from Andrographis paniculata. Chinese journal of natural medicines. 2020 Sep; 18(9):659-665. doi: 10.1016/s1875-5364(20)60004-8. [PMID: 32928509]
  • E A Hashish, S A Elgaml, Aha El-Fattah, S I Shalaby, S Abdelaziz. β-Amyrin supplementation ameliorates the toxic effect of glycerol in the kidney of rat model. Human & experimental toxicology. 2020 Jul; 39(7):930-937. doi: 10.1177/0960327120907136. [PMID: 32081053]
  • Bruna Karen Cardoso, Herika Line Marko de Oliveira, Ulisses Zonta Melo, Carla Maria Mariano Fernandez, Caio Franco de Araújo Almeida Campo, José Eduardo Gonçalves, Antônio Laverde, Mariza Barion Romagnolo, Giani Andrea Linde, Zilda Cristiani Gazim. Antioxidant activity of α and β-amyrin isolated from Myrcianthes pungens leaves. Natural product research. 2020 Jun; 34(12):1777-1781. doi: 10.1080/14786419.2018.1525715. [PMID: 30465617]
  • Isaac T Henneh, Boshi Huang, Faik N Musayev, Rana Al Hashimi, Martin K Safo, Francis A Armah, Elvis O Ameyaw, Christian K Adokoh, Martins Ekor, Yan Zhang. Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae). Bioorganic chemistry. 2020 05; 98(?):103744. doi: 10.1016/j.bioorg.2020.103744. [PMID: 32179280]
  • Gari Vidal Ccana-Ccapatinta, Jennyfer Andrea Aldana Mejía, Matheus Hikaru Tanimoto, Milton Groppo, Jean Carlos Andrade Sarmento de Carvalho, Jairo Kenupp Bastos. Dalbergia ecastaphyllum (L.) Taub. and Symphonia globulifera L.f.: The Botanical Sources of Isoflavonoids and Benzophenones in Brazilian Red Propolis. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092060. [PMID: 32354180]
  • Matthew P Dale, Tessa Moses, Emily J Johnston, Susan J Rosser. A systematic comparison of triterpenoid biosynthetic enzymes for the production of oleanolic acid in Saccharomyces cerevisiae. PloS one. 2020; 15(5):e0231980. doi: 10.1371/journal.pone.0231980. [PMID: 32357188]
  • Fu-Sheng Zhang, Xuan Zhang, Qian-Yu Wang, Ya-Jie Pu, Chen-Hui Du, Xue-Mei Qin, Hong-Ling Tian, Yun-Lan Lian, Min-Sheng Li, Yu Chen, Cun-Gen Ma. Cloning, Yeast Expression, and Characterization of a β-Amyrin C-28 Oxidase (CYP716A249) Involved in Triterpenoid Biosynthesis in Polygala tenuifolia. Biological & pharmaceutical bulletin. 2020; 43(12):1839-1846. doi: 10.1248/bpb.b20-00343. [PMID: 33268701]
  • Garima Ayachit, Inayatullah Shaikh, Preeti Sharma, Bhavika Jani, Labdhi Shukla, Priyanka Sharma, Shivarudrappa B Bhairappanavar, Chaitanya Joshi, Jayashankar Das. De novo transcriptome of Gymnema sylvestre identified putative lncRNA and genes regulating terpenoid biosynthesis pathway. Scientific reports. 2019 10; 9(1):14876. doi: 10.1038/s41598-019-51355-x. [PMID: 31619732]
  • Ueveton Pimentel da Silva, Gabriela Milane Furlani, Antônio Jacinto Demuner, Otávio Luis Marques da Silva, Eduardo Vinícius Vieira Varejão. Allelopathic activity and chemical constituents of extracts from roots of Euphorbia heterophylla L. Natural product research. 2019 Sep; 33(18):2681-2684. doi: 10.1080/14786419.2018.1460829. [PMID: 29629832]
  • Zhixue Wu, Hui Xu, Meiling Wang, Ruoting Zhan, Weiwen Chen, Ren Zhang, Zaoyuan Kuang, Fengxue Zhang, Kui Wang, Jiangyong Gu. Molecular Docking and Molecular Dynamics Studies on Selective Synthesis of α-Amyrin and β-Amyrin by Oxidosqualene Cyclases from Ilex Asprella. International journal of molecular sciences. 2019 Jul; 20(14):. doi: 10.3390/ijms20143469. [PMID: 31311103]
  • Ali M El-Halawany, Samir M Osman, Hossam M Abdallah. Cytotoxic constituents from Vicia monantha subsp. monantha seeds. Natural product research. 2019 Jun; 33(12):1783-1786. doi: 10.1080/14786419.2018.1434638. [PMID: 29411647]
  • Hu Liu, Jingjing Fan, Chen Wang, Chun Li, Xiaohong Zhou. Enhanced β-Amyrin Synthesis in Saccharomyces cerevisiae by Coupling An Optimal Acetyl-CoA Supply Pathway. Journal of agricultural and food chemistry. 2019 Apr; 67(13):3723-3732. doi: 10.1021/acs.jafc.9b00653. [PMID: 30808164]
  • Meng-Chu Sun, Er-Kun Chao, Xin-Yao Su, Min Zhu, Yong Su, Guang-Tao Qian, Shi-Lin Chen, Cai-Xia Wang, Jian-Ping Xue. [Study of heterologous efficient synthesis of β-amyrin and high-density fermentation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Apr; 44(7):1341-1349. doi: 10.19540/j.cnki.cjcmm.20190129.011. [PMID: 31090290]
  • Abraham Giacoman-Martínez, Francisco J Alarcón-Aguilar, Alejandro Zamilpa, Sergio Hidalgo-Figueroa, Gabriel Navarrete-Vázquez, Rebeca García-Macedo, Rubén Román-Ramos, Julio C Almanza-Pérez. Triterpenoids from Hibiscus sabdariffa L. with PPARδ/γ Dual Agonist Action: In Vivo, In Vitro and In Silico Studies. Planta medica. 2019 Mar; 85(5):412-423. doi: 10.1055/a-0824-1316. [PMID: 30650453]
  • Guo-Yan Mo, Fang Huang, Yin Fang, Lin-Tao Han, Kayla K Pennerman, Li-Jing Bu, Xiao-Wei DU, Joan W Bennett, Guo-Hua Yin. Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones. Chinese journal of natural medicines. 2019 Feb; 17(2):131-144. doi: 10.1016/s1875-5364(19)30015-9. [PMID: 30797419]
  • Amaurilio O Nogueira, Yasmin Ingrid S Oliveira, Beatriz L Adjafre, Maria E Amaral de Moraes, Gislei F Aragão. Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review. Fundamental & clinical pharmacology. 2019 Feb; 33(1):4-12. doi: 10.1111/fcp.12402. [PMID: 30003594]
  • Karina Moura de Melo, Francisca Tuelly Bandeira de Oliveira, Rose Anny Costa Silva, Ana Luiza Gomes Quinderé, José Delano Barreto Marinho Filho, Ana Jérsia Araújo, Eanes Delgado Barros Pereira, Adonias Almeida Carvalho, Mariana Helena Chaves, Vietla Satyanarayana Rao, Flávia Almeida Santos. α, β-Amyrin, a pentacyclic triterpenoid from Protium heptaphyllum suppresses adipocyte differentiation accompanied by down regulation of PPARγ and C/EBPα in 3T3-L1 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):1860-1866. doi: 10.1016/j.biopha.2018.11.027. [PMID: 30551441]
  • Pankajkumar B Nariya, Vinay J Shukla, R N Acharya, Mukeshkumar B Nariya, Jayesh M Dhalani, Anilkumar S Patel, Pratik A Ambasana. Triterpenoid and Fatty Acid Contents from the Stem Bark of Cordia dichotoma (Forst f.). Folia medica. 2018 Dec; 60(4):594-600. doi: 10.2478/folmed-2018-0026. [PMID: 31188773]
  • Yuan Yu, Pengcheng Chang, Huan Yu, Huiyong Ren, Danning Hong, Zeyan Li, Ying Wang, Hao Song, Yixin Huo, Chun Li. Productive Amyrin Synthases for Efficient α-Amyrin Synthesis in Engineered Saccharomyces cerevisiae. ACS synthetic biology. 2018 10; 7(10):2391-2402. doi: 10.1021/acssynbio.8b00176. [PMID: 30216049]
  • Zahra Shirazi, Ali Aalami, Masoud Tohidfar, Mohammad Mehdi Sohani. Metabolic Engineering of Glycyrrhizin Pathway by Over-Expression of Beta-amyrin 11-Oxidase in Transgenic Roots of Glycyrrhiza glabra. Molecular biotechnology. 2018 Jun; 60(6):412-419. doi: 10.1007/s12033-018-0082-7. [PMID: 29687371]
  • Olumuyiwa O Ogunlaja, Roshila Moodley, Moganavelli Singh, Himansu Baijnath, Sreekanth B Jonnalagadda. Cytotoxic activity of the bioactive principles from Ficus burtt-davyi. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2018 Apr; 53(4):261-275. doi: 10.1080/03601234.2017.1410385. [PMID: 29278988]
  • Pritipadma Panda, Priyanka Dash, Goutam Ghosh. Chemometric profile, antioxidant and tyrosinase inhibitory activity of Camel's foot creeper leaves (Bauhinia vahlii). Natural product research. 2018 Mar; 32(5):596-599. doi: 10.1080/14786419.2017.1326487. [PMID: 28508671]
  • Chuansong Zhan, Shakeel Ahmed, Sheng Hu, Shuang Dong, Qian Cai, Tewu Yang, Xuekui Wang, Xiaohua Li, Xuebo Hu. Cytochrome P450 CYP716A254 catalyzes the formation of oleanolic acid from β-amyrin during oleanane-type triterpenoid saponins biosynthesis in Anemone flaccida. Biochemical and biophysical research communications. 2018 01; 495(1):1271-1277. doi: 10.1016/j.bbrc.2017.11.142. [PMID: 29180016]
  • Ming Zhu, Caixia Wang, Wentao Sun, Anqi Zhou, Ying Wang, Genlin Zhang, Xiaohong Zhou, Yixin Huo, Chun Li. Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants. Metabolic engineering. 2018 01; 45(?):43-50. doi: 10.1016/j.ymben.2017.11.009. [PMID: 29196123]
  • Ahmed Al-Harrasi, Najeeb Ur Rehman, Abdul Latif Khan, Muhammed Al-Broumi, Issa Al-Amri, Javid Hussain, Hidayat Hussain, René Csuk. Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11β-Dihydroxy BA as precursors in biosynthesis of boswellic acids. PloS one. 2018; 13(6):e0198666. doi: 10.1371/journal.pone.0198666. [PMID: 29912889]
  • Karem H Alzoubi, Nasab Q Rawashdeh, Omar F Khabour, Tamam El-Elimat, Hanan Albataineh, Hamzeh M Al-Zghool, Feras Q Alali. Evaluation of the Effect of Moringa peregrina Extract on Learning and Memory: Role of Oxidative Stress. Journal of molecular neuroscience : MN. 2017 Dec; 63(3-4):355-363. doi: 10.1007/s12031-017-0986-x. [PMID: 29082469]
  • Juan Xiong, Jiang Wan, Jie Ding, Pei-Pei Wang, Guang-Lei Ma, Jia Li, Jin-Feng Hu. Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana. Journal of natural products. 2017 11; 80(11):2874-2882. doi: 10.1021/acs.jnatprod.7b00241. [PMID: 29064696]
  • Walter Ferreira da Silva Júnior, Jonas Gabriel de Oliveira Pinheiro, Danielle Lima Bezerra de Menezes, Natan Emanuell de Sobral E Silva, Patrícia Danielle Oliveira de Almeida, Emerson Silva Lima, Valdir Florêncio da Veiga Júnior, Eduardo Pereira de Azevedo, Ádley Antonini Neves de Lima. Development, Physicochemical Characterization and In Vitro Anti-Inflammatory Activity of Solid Dispersions of α,β Amyrin Isolated from Protium Oilresin. Molecules (Basel, Switzerland). 2017 Sep; 22(9):. doi: 10.3390/molecules22091512. [PMID: 28891943]
  • Miho Takemura, Rie Tanaka, Norihiko Misawa. Pathway engineering for the production of β-amyrin and cycloartenol in Escherichia coli-a method to biosynthesize plant-derived triterpene skeletons in E. coli. Applied microbiology and biotechnology. 2017 Sep; 101(17):6615-6625. doi: 10.1007/s00253-017-8409-z. [PMID: 28710558]
  • S Divya Reddy, Bandi Siva, V S Phani Babu, M Vijaya, V Lakshma Nayak, Reeta Mandal, Ashok K Tiwari, P Shashikala, K Suresh Babu. New cycloartane type-triterpenoids from the areal parts of Caragana sukiensis and their biological activities. European journal of medicinal chemistry. 2017 Aug; 136(?):74-84. doi: 10.1016/j.ejmech.2017.04.065. [PMID: 28482219]
  • L F Jorge, A B Meniqueti, R F Silva, K A Santos, E A Da Silva, J E Gonçalves, C M De Rezende, N B Colauto, Z C Gazim, G A Linde. Antioxidant activity and chemical composition of oleoresin from leaves and flowers of Brunfelsia uniflora. Genetics and molecular research : GMR. 2017 Aug; 16(3):. doi: 10.4238/gmr16039714. [PMID: 28829897]
  • Tasmia Tahsin, Jean Duplex Wansi, Afaf Al-Groshi, Andrew Evans, Lutfun Nahar, Claire Martin, Satyajit Dey Sarker. Cytotoxic Properties of the Stem Bark of Citrus reticulata Blanco (Rutaceae). Phytotherapy research : PTR. 2017 Aug; 31(8):1215-1219. doi: 10.1002/ptr.5842. [PMID: 28568378]
  • Rajesh Chandra Misra, Shubha Sharma, Sandeep, Anchal Garg, Chandan Singh Chanotiya, Sumit Ghosh. Two CYP716A subfamily cytochrome P450 monooxygenases of sweet basil play similar but nonredundant roles in ursane- and oleanane-type pentacyclic triterpene biosynthesis. The New phytologist. 2017 Apr; 214(2):706-720. doi: 10.1111/nph.14412. [PMID: 28967669]
  • A Thirupathi, P C Silveira, R T Nesi, R A Pinho. β-Amyrin, a pentacyclic triterpene, exhibits anti-fibrotic, anti-inflammatory, and anti-apoptotic effects on dimethyl nitrosamine-induced hepatic fibrosis in male rats. Human & experimental toxicology. 2017 Feb; 36(2):113-122. doi: 10.1177/0960327116638727. [PMID: 27009110]
  • Karine Maria Martins Bezerra Carvalho, Tiago Sousa de Melo, Karina Moura de Melo, Ana Luiza Gomes Quinderé, Francisca Tuelly Bandeira de Oliveira, Ana Flávia Seraine Custódio Viana, Paulo Iury Gomes Nunes, Josiane da Silva Quetz, Daniel de Araújo Viana, Armenio André de Carvalho Almeida da Silva, Alexandre Havt, Said Gonçalves da Cruz Fonseca, Mariana Helena Chaves, Vietla Satyanarayana Rao, Flávia Almeida Santos. Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses. Planta medica. 2017 Feb; 83(3-04):285-291. doi: 10.1055/s-0042-114222. [PMID: 27525508]
  • Ryoichi Yano, Kyoko Takagi, Yoshitake Takada, Kyosuke Mukaiyama, Chigen Tsukamoto, Takashi Sayama, Akito Kaga, Toyoaki Anai, Satoru Sawai, Kiyoshi Ohyama, Kazuki Saito, Masao Ishimoto. Metabolic switching of astringent and beneficial triterpenoid saponins in soybean is achieved by a loss-of-function mutation in cytochrome P450 72A69. The Plant journal : for cell and molecular biology. 2017 02; 89(3):527-539. doi: 10.1111/tpj.13403. [PMID: 27775214]
  • Pankaj Prabhakar, K H Reeta, Subir Kumar Maulik, Amit Kumar Dinda, Yogendra Kumar Gupta. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2017 Jan; 42(1):23-32. doi: 10.1139/apnm-2016-0088. [PMID: 27911087]
  • Jin-Long Li, Lei Wu, Jian Wu, Hong-Xuan Feng, Hong-Min Wang, Yan Fu, Ru-Jun Zhang, Hai-Yan Zhang, Wei-Min Zhao. Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus. Journal of natural products. 2016 11; 79(11):2774-2779. doi: 10.1021/acs.jnatprod.6b00314. [PMID: 27791375]
  • Tatiana M Souza-Moreira, Thaís B Alves, Karina A Pinheiro, Lidiane G Felippe, Gustavo M A De Lima, Tatiana F Watanabe, Cristina C Barbosa, Vânia A F F M Santos, Norberto P Lopes, Sandro R Valentini, Rafael V C Guido, Maysa Furlan, Cleslei F Zanelli. Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene. Scientific reports. 2016 11; 6(?):36858. doi: 10.1038/srep36858. [PMID: 27874020]
  • Yanling Liu, Zhongjuan Zhao, Zheyong Xue, Long Wang, Yunfei Cai, Peng Wang, Tiandi Wei, Jing Gong, Zhenhua Liu, Juan Li, Shuo Li, Fengning Xiang. An Intronless β-amyrin Synthase Gene is More Efficient in Oleanolic Acid Accumulation than its Paralog in Gentiana straminea. Scientific reports. 2016 09; 6(?):33364. doi: 10.1038/srep33364. [PMID: 27624821]
  • Patrícia de Brum Vieira, Nícolas Luiz Feijó Silva, Gloria Narjara Santos da Silva, Denise Brentan Silva, Norberto Peporine Lopes, Simone Cristina Baggio Gnoatto, Márcia Vanusa da Silva, Alexandre José Macedo, Jaume Bastida, Tiana Tasca. Caatinga plants: Natural and semi-synthetic compounds potentially active against Trichomonas vaginalis. Bioorganic & medicinal chemistry letters. 2016 May; 26(9):2229-36. doi: 10.1016/j.bmcl.2016.03.061. [PMID: 27020521]
  • F Maiyo, R Moodley, M Singh. PHYTOCHEMISTRY, CYTOTOXICITY AND APOPTOSIS STUDIES OF B-SITOSTEROL-3-O-GLUCOSIDE AND Β -AMYRIN FROM PRUNUS AFRICANA. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2016; 13(4):105-112. doi: 10.21010/ajtcam.v13i4.15. [PMID: 28852726]
  • Bekzod Khakimov, Vera Kuzina, Pernille Ø Erthmann, Ery Odette Fukushima, Jörg M Augustin, Carl Erik Olsen, Jelle Scholtalbers, Hanne Volpin, Sven Bode Andersen, Thure P Hauser, Toshiya Muranaka, Søren Bak. Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins in Nicotiana benthamiana. The Plant journal : for cell and molecular biology. 2015 Nov; 84(3):478-90. doi: 10.1111/tpj.13012. [PMID: 26333142]
  • Carlos Quintal-Novelo, Luis W Torres-Tapia, Rosa Moo-Puc, Sergio R Peraza-Sanchez. Bio-guided Isolation of a New Sesterterpene from Serjania goniocarpa. Natural product communications. 2015 Sep; 10(9):1513-6. doi: ". [PMID: 26594746]
  • Cun-qin Wang, Hong-ting Wang, Hao Xu, Yan-ping Shi. [Triterpenoids from Leaves of Ilex latifolia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Aug; 38(8):1653-5. doi: ". [PMID: 26983238]
  • Yuan-zhi Yao, Sheng-hua Li. [Chemical Constituents from Angelica keiskei]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Aug; 38(8):1656-60. doi: . [PMID: 26983239]
  • Perwez Alam, Mohamed Fahad Alajmi, Nasir Ali Siddiqui, Adnan Jathlan Al-Rehaily, Hattan Alharbi, Omer Ahmed Basudan, Afzal Hussain. Densitometric validation and analysis of biomarker β-amyrin in different Acacia species (leaves) grown in Kingdom of Saudi Arabia by high performance thin-layer chromatography. Pakistan journal of pharmaceutical sciences. 2015 Jul; 28(4 Suppl):1485-91. doi: . [PMID: 26431661]
  • Qiang Wei, Xiao-ying Ji, Fei Xu, Qian-rong Li, Hao Yin. [Chemical Constituents from Leaves of Hibiscus syriacus and Their α-Glucosidase Inhibitory Activities]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 May; 38(5):975-9. doi: . [PMID: 26767290]
  • Eva Puniani, Christian Cayer, Pamela Kent, Martha Mullally, Pablo Sánchez-Vindas, Luis Poveda Álvarez, Victor Cal, Zul Merali, John T Arnason, Tony Durst. Ethnopharmacology of Souroubea sympetala and Souroubea gilgii (Marcgraviaceae) and identification of betulinic acid as an anxiolytic principle. Phytochemistry. 2015 May; 113(?):73-8. doi: 10.1016/j.phytochem.2014.02.017. [PMID: 24641939]
  • Yong Chen, Jian Zuo, Jian-wei Chen, Xiang Li. [Chemical Constituents from Claoxylon indicum Stems]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Apr; 38(4):761-3. doi: . [PMID: 26672343]
  • Ping Qiu, Qi-zhi Wang, Min Yin, Ming Wang, You-yi Zhao, Yu Shan, Xu Feng. [Chemical Constituents of Ethyl Acetate Fraction of Suaeda glauca]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Apr; 38(4):751-3. doi: . [PMID: 26672340]
  • Dharmendra Singh, P V Arya, Ashutosh Sharma, M P Dobhal, R S Gupta. Modulatory potential of α-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats. Journal of ethnopharmacology. 2015 Feb; 161(?):186-93. doi: 10.1016/j.jep.2014.12.025. [PMID: 25542388]
  • Marcin Broniatowski, Patrycja Mastalerz, Michał Flasiński. Studies of the interactions of ursane-type bioactive terpenes with the model of Escherichia coli inner membrane-Langmuir monolayer approach. Biochimica et biophysica acta. 2015 Feb; 1848(2):469-76. doi: 10.1016/j.bbamem.2014.10.024. [PMID: 25450351]
  • Kripa Krishnan, Limi Elizabeth Mathew, N R Vijayalakshmi, A Helen. Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus. Inflammopharmacology. 2014 Dec; 22(6):373-85. doi: 10.1007/s10787-014-0218-8. [PMID: 25300965]
  • Tessa Moses, Johan M Thevelein, Alain Goossens, Jacob Pollier. Comparative analysis of CYP93E proteins for improved microbial synthesis of plant triterpenoids. Phytochemistry. 2014 Dec; 108(?):47-56. doi: 10.1016/j.phytochem.2014.10.002. [PMID: 25453910]
  • Nkeoma Nkasi Okoye, Daniel Lotanna Ajaghaku, Henry Nnaemeka Okeke, Emmanuel Emeka Ilodigwe, Chukwuemeka Sylvester Nworu, Festus Basden C Okoye. beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity. Pharmaceutical biology. 2014 Nov; 52(11):1478-86. doi: 10.3109/13880209.2014.898078. [PMID: 25026352]
  • Fakhria M Razeq, Dylan K Kosma, Owen Rowland, Isabel Molina. Extracellular lipids of Camelina sativa: characterization of chloroform-extractable waxes from aerial and subterranean surfaces. Phytochemistry. 2014 Oct; 106(?):188-196. doi: 10.1016/j.phytochem.2014.06.018. [PMID: 25081105]
  • Ariane C Kemen, Suvi Honkanen, Rachel E Melton, Kim C Findlay, Sam T Mugford, Keiko Hayashi, Kosmas Haralampidis, Susan J Rosser, Anne Osbourn. Investigation of triterpene synthesis and regulation in oats reveals a role for β-amyrin in determining root epidermal cell patterning. Proceedings of the National Academy of Sciences of the United States of America. 2014 Jun; 111(23):8679-84. doi: 10.1073/pnas.1401553111. [PMID: 24912185]
  • Ying Liu, Hong-Hao Chen, Hao Wen, Ya Gao, Li-Qiang Wang, Chun-Sheng Liu. Enhancing the accumulation of beta-amyrin in Saccharomyces cerevisiae by co-expression of Glycyrrhiza uralensis squalene synthase 1 and beta-amyrin synthase genes. Yao xue xue bao = Acta pharmaceutica Sinica. 2014 May; 49(5):734-41. doi: . [PMID: 25151748]
  • Xiasheng Zheng, Hui Xu, Xinye Ma, Ruoting Zhan, Weiwen Chen. Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq. International journal of molecular sciences. 2014 Apr; 15(4):5970-87. doi: 10.3390/ijms15045970. [PMID: 24722569]
  • Sadaf Naz Ashraf, Muhammad Zubair, Komal Rizwan, Rasool Bakhsh Tareen, Nasir Rasool, Muhammad Zia-Ul-Haq, Sezai Ercisli. Compositional studies and Biological activities of Perovskia abrotanoides Kar. oils. Biological research. 2014 Apr; 47(?):12. doi: 10.1186/0717-6287-47-12. [PMID: 25052892]
  • Pooi Yin Chung, Lip Yong Chung, Parasakthi Navaratnam. Potential targets by pentacyclic triterpenoids from Callicarpa farinosa against methicillin-resistant and sensitive Staphylococcus aureus. Fitoterapia. 2014 Apr; 94(?):48-54. doi: 10.1016/j.fitote.2014.01.026. [PMID: 24508863]
  • Nawal M Al Musayeib, Ramzi A Mothana, Sabrin R M Ibrahim, Ali A El Gamal, Shaza M Al-Massarani. Klodorone A and klodorol A: new triterpenes from Kleinia odora. Natural product research. 2014; 28(15):1142-6. doi: 10.1080/14786419.2014.915831. [PMID: 24831019]
  • Looi Ting Yeong, Roslida Abdul Hamid, Latifah Saiful Yazan, Huzwah Khaza'ai, Dayang Erna Zulaikha Awang Hamsin. Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro. Natural product research. 2014; 28(22):2026-30. doi: 10.1080/14786419.2014.917415. [PMID: 24836304]
  • Narendra Kumar Singh, Virendra Pratap Singh. Anticancer activity of the roots of Ichnocarpus frutescens R. Br. and isolated triterpenes. Pakistan journal of pharmaceutical sciences. 2014 Jan; 27(1):187-91. doi: ". [PMID: 24374448]
  • Wei-Yang Jing, Chao Jiang, Feng Ji, Hui-Ming Hua, Zhan-Lin Li. Chemical constituents from the stem barks of Garcinia multiflora. Journal of Asian natural products research. 2013 Nov; 15(11):1152-7. doi: 10.1080/10286020.2013.819854. [PMID: 23895230]
  • Aminu Muhammad, Hasnah Mohd Sirat. Potent microbial and tyrosinase inhibitors from stem bark of Bauhinia rufescens (Fabaceae). Natural product communications. 2013 Oct; 8(10):1435-7. doi: . [PMID: 24354195]
  • Adeleke Clement Adebajo, Marcus Durojaye Ayoola, Samuel Akintunde Odediran, Adetunji Joseph Aladesanmi, Thomas Jürgen Schmidt, Eugene Joseph Verspohl. Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem. Journal of diabetes. 2013 Sep; 5(3):336-43. doi: 10.1111/1753-0407.12019. [PMID: 23217111]
  • Yao Zhang, Ting-Ting Feng, Zhi Zhao, Ying Zhou. [Study on the chemical constituents of mori cortex]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Jul; 36(7):1101-3. doi: . [PMID: 24417147]
  • Jin-Feng Wei, Lin Chen, Wei Wang, Wen-Yi Kang. [Chemical constituents of Lysimachia paridiformis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Jul; 36(7):1096-9. doi: ". [PMID: 24417145]
  • Catharina E Fingolo, Thabata de S Santos, Marcelo D M Vianna Filho, Maria Auxiliadora C Kaplan. Triterpene esters: natural products from Dorstenia arifolia (Moraceae). Molecules (Basel, Switzerland). 2013 Apr; 18(4):4247-56. doi: 10.3390/molecules18044247. [PMID: 23579992]
  • Yun Chen, Guo-Kai Wang, Can Wu, Min-Jian Qin. [Chemical constituents of Gentiana rhodantha]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Feb; 38(3):362-5. doi: ". [PMID: 23668010]
  • Anna Szakiel, Cezary Pączkowski, Satu Huttunen. Triterpenoid content of berries and leaves of bilberry Vaccinium myrtillus from Finland and Poland. Journal of agricultural and food chemistry. 2012 Dec; 60(48):11839-49. doi: 10.1021/jf3046895. [PMID: 23157739]
  • Lili Huang, Jia Li, Hechun Ye, Changfu Li, Hong Wang, Benye Liu, Yansheng Zhang. Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta. 2012 Nov; 236(5):1571-81. doi: 10.1007/s00425-012-1712-0. [PMID: 22837051]
  • Ming Fu, You-Ya Niu, Juan Yu, Qing-Tong Kong. [Study on the chemical constituents in Pouzolzia zeylanica]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Nov; 35(11):1778-81. doi: . [PMID: 23627087]
  • Madepalli Byrappa Gowdu Viswanathan, Jesu Doss Jeya Ananthi, Perumal Sathish Kumar. Antimicrobial activity of bioactive compounds and leaf extracts in Jatropha tanjorensis. Fitoterapia. 2012 Oct; 83(7):1153-9. doi: 10.1016/j.fitote.2012.07.007. [PMID: 22884742]
  • Christopher Buschhaus, Reinhard Jetter. Composition and physiological function of the wax layers coating Arabidopsis leaves: β-amyrin negatively affects the intracuticular water barrier. Plant physiology. 2012 Oct; 160(2):1120-9. doi: 10.1104/pp.112.198473. [PMID: 22885935]
  • A C Siani, M J Nakamura, M R R Tappin, S S Monteiro, A C Guimarães, M F S Ramos. Chemical composition of South American Burseraceae non-volatile oleoresins and preliminary solubility assessment of their commercial blend. Phytochemical analysis : PCA. 2012 Sep; 23(5):529-39. doi: 10.1002/pca.2351. [PMID: 22323110]
  • Flávia Almeida Santos, Julyanne Torres Frota, Bruno Rodrigues Arruda, Tiago Sousa de Melo, Armenio André de Carvalho Almeida da Silva, Gerly Anne de Castro Brito, Mariana Helena Chaves, Vietla Satyanarayana Rao. Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice. Lipids in health and disease. 2012 Aug; 11(?):98. doi: 10.1186/1476-511x-11-98. [PMID: 22867128]
  • Vanessa Janovik, Aline Augusti Boligon, Janaína Kieling Frohlich, Thiago Guilherme Schwanz, Tarciele Venturini Pozzebon, Sydney Hartz Alves, Margareth Linde Athayde. Isolation and chromatographic analysis of bioactive triterpenoids from the bark extract of Cariniana domestica (Mart) Miers. Natural product research. 2012; 26(1):66-71. doi: 10.1080/14786419.2010.535160. [PMID: 21827285]
  • Jianhong Ching, Wei-Li Soh, Chay-Hoon Tan, Jun-Feng Lee, Jiun-Yu Christina Tan, Jun Yang, Chun-Wei Yap, Hwee-Ling Koh. Identification of active compounds from medicinal plant extracts using gas chromatography-mass spectrometry and multivariate data analysis. Journal of separation science. 2012 Jan; 35(1):53-9. doi: 10.1002/jssc.201100705. [PMID: 22127806]
  • Javid Hussain, Najeeb Ur Rehman, Hidayat Hussain, Liaqat Ali, Ahmed Al-Harrasi. Two new phthalate derivatives from Nepeta clarkei (Labiatae). Journal of Asian natural products research. 2012; 14(1):22-6. doi: 10.1080/10286020.2011.620954. [PMID: 22263590]