NCBI Taxonomy: 49188
Aconitum (ncbi_taxid: 49188)
found 16 associated metabolites at genus taxonomy rank level.
Ancestor: Delphinieae
Child Taxonomies: Aconitum ferox, Aconitum gigas, Aconitum paskoi, Aconitum rockii, Aconitum ciliare, Aconitum hookeri, Aconitum nagarum, Aconitum okuyamae, Aconitum pendulum, Aconitum villosum, Aconitum sanyoense, Aconitum yamazakii, Aconitum yuparense, Aconitum decipiens, Aconitum senanense, Aconitum taronense, Aconitum tsaii, Aconitum nanum, Aconitum laeve, Aconitum baicalense, Aconitum kiyomiense, Aconitum nipponicum, Aconitum fengii, Aconitum firmum, Aconitum zigzag, Aconitum flavum, Aconitum henryi, Aconitum kitadakense, Aconitum longtouense, Aconitum maximum, Aconitum georgei, Aconitum iinumae, Aconitum elwesii, Aconitum nasutum, Aconitum toxicum, Aconitum hicksii, Aconitum nemorum, Aconitum smithii, Aconitum degenii, Aconitum anthora, Aconitum tonense, Aconitum pilipes, Aconitum iidemontanum, Aconitum sachalinense, Aconitum stylosum, Aconitum pentheri, Aconitum scaposum, Aconitum delavayi, Aconitum burnatii, Aconitum cammarum, Aconitum pallasii, Aconitum tauricum, Aconitum plicatum, Aconitum brunneum, Aconitum superbum, Aconitum pomeense, Aconitum elliotii, Aconitum soyaense, Aconitum volubile, Aconitum flerovii, Aconitum jaluense, Aconitum ludlowii, Aconitum habaense, Aconitum apetalum, Aconitum napellus, Aconitum palmatum, Aconitum barbatum, Aconitum pukeense, Aconitum umbrosum, Aconitum coreanum, Aconitum ajanense, Aconitum krylovii, Aconitum weixiense, Aconitum sajanense, Aconitum duclouxii, Aconitum ramulosum, Aconitum kirinense, Aconitum sczukinii, Aconitum jeholense, Aconitum taipeicum, Aconitum contortum, Aconitum monanthum, Aconitum milinense, Aconitum loczyanum, Aconitum refractum, Aconitum x berdaui, Aconitum legendrei, Aconitum huiliense, Aconitum nevadense, Aconitum fukutomei, Aconitum napiforme, Aconitum forrestii, Aconitum orientale, Aconitum balfourii, Aconitum violaceum, Aconitum japonicum, Aconitum misaoanum, Aconitum angustius, Aconitum monticola, Aconitum moschatum, Aconitum krasnoboroffii, Aconitum sukaczevii, Aconitum tanguticum, Aconitum franchetii, Aconitum cymbulatum, Aconitum gassanense, Aconitum pterocaule, Aconitum stapfianum, Aconitum episcopale, Aconitum bulleyanum, Aconitum piepunense, Aconitum naviculare, Aconitum longilobum, Aconitum talassicum, Aconitum tongolense, Aconitum polycarpum, Aconitum kongboense, Aconitum wumengense, Aconitum bartlettii, Aconitum finetianum, Aconitum pulchellum, Aconitum reclinatum, Aconitum rilongense, Aconitum lycoctonum, Aconitum moldavicum, Aconitum variegatum, Aconitum iochanicum, Aconitum desoulavyi, Aconitum falciforme, Aconitum bailangense, Aconitum columbianum, Aconitum racemulosum, Aconitum hemsleyanum, Aconitum brachypodum, Aconitum transsectum, Aconitum x exaltatum, Aconitum sungpanense, Aconitum kusnezoffii, Aconitum lasiostomum, Aconitum glandulosum, Aconitum bucovinense, Aconitum incisofidum, Aconitum lasiocarpum, Aconitum leiwuqiense, Aconitum pilopetalum, Aconitum nielamuense, Aconitum tatsienense, Aconitum x hebegynum, Aconitum geniculatum, Aconitum chrysopilum, Aconitum karakolicum, Aconitum incisifidum, Aconitum jinyangense, Aconitum chasmanthum, Aconitum leucostomum, Aconitum iranshahrii, Aconitum pseudolaeve, Aconitum chiisanense, Aconitum hakusanense, Aconitum novoluridum, Aconitum soongaricum, Aconitum spathulatum, Aconitum pauciflorum, Aconitum crassiflorum, Aconitum sinomontanum, unclassified Aconitum, Aconitum bracteolatum, Aconitum spiripetalum, Aconitum x pawlowskii, Aconitum polyschistum, Aconitum carmichaelii, Aconitum fletcheranum, Aconitum lucidusculum, Aconitum anthoroideum, Aconitum ouvrardianum, Aconitum ranunculoides, Aconitum khanminthunii, Aconitum paniculigerum, Aconitum rotundifolium, Aconitum tuguancunense, Aconitum vilmorinianum, Aconitum cannabifolium, Aconitum glabrisepalum, Aconitum macrorhynchum, Aconitum nutantiflorum, Aconitum asahikawaense, Aconitum hamatipetalum, Aconitum bulbilliferum, Aconitum alboviolaceum, Aconitum liangshanicum, Aconitum phyllostegium, Aconitum chrysotrichum, Aconitum liljestrandii, Aconitum chienningense, Aconitum sessiliflorum, Aconitum quelpaertense, Aconitum heterophyllum, Aconitum wangyedianense, Aconitum puchonroenicum, Aconitum grossedentatum, Aconitum seravschanicum, Aconitum austrokoreense, Aconitum septentrionale, Aconitum shennongjiaense, Aconitum birobidshanicum, Aconitum delphiniifolium, Aconitum artemisiifolium, Aconitum richardsonianum, Aconitum x czarnohorense, Aconitum sinonapelloides, Aconitum brevicalcaratum, Aconitum longecassidatum, Aconitum ranunculifolium, Aconitum campylorrhynchum, Aconitum austroyunnanense, Aconitum pseudodivaricatum, Aconitum tschangbaischanense
Mesaconitine
Mesaconitine is a diterpenoid. Mesaconitine is a natural product found in Aconitum anthora, Aconitum napellus, and other organisms with data available. Origin: Plant; SubCategory_DNP: Terpenoid alkaloids, Diterpene alkaloid, Aconitum alkaloid Annotation level-1 Mesaconitine is the main active component of genus aconitum plants. IC50 value: Target: in vitro: In HUVECs, 30 microM mesaconitine increased the [Ca(2+)](i) level in the presence of extracellular CaCl(2) and NaCl, and the response was inhibited by KBR7943. Mesaconitine increased intracellular Na(+) concentration level in HUVECs. The [Ca(2+)](i) response by mesaconitine was inhibited by 100 microM D-tubocurarine [1]. Mesaconitine at 30 microM inhibited 3 microM phenylephrine-induced contraction in the endothelium-intact, but not endothelium-denuded, aortic rings [2]. MA promoted the alpha-MT-induced decrease in NE levels in hippocampus, medulla oblongata plus pons and spinal cord [3]. Mesaconitine is the main active component of genus aconitum plants. IC50 value: Target: in vitro: In HUVECs, 30 microM mesaconitine increased the [Ca(2+)](i) level in the presence of extracellular CaCl(2) and NaCl, and the response was inhibited by KBR7943. Mesaconitine increased intracellular Na(+) concentration level in HUVECs. The [Ca(2+)](i) response by mesaconitine was inhibited by 100 microM D-tubocurarine [1]. Mesaconitine at 30 microM inhibited 3 microM phenylephrine-induced contraction in the endothelium-intact, but not endothelium-denuded, aortic rings [2]. MA promoted the alpha-MT-induced decrease in NE levels in hippocampus, medulla oblongata plus pons and spinal cord [3].
Aconitine
D049990 - Membrane Transport Modulators > D062687 - Sodium Channel Agonists > D061585 - Voltage-Gated Sodium Channel Agonists D007155 - Immunologic Factors Aconitine is a diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively. It is functionally related to an aconitane. Aconitine is a natural product found in Aconitum anthora, Aconitum napellus, and other organisms with data available. Aconitine is a plant toxin found in species of wolfsbane (Aconitum genus). It is a neurotoxin previously used as an antipyretic and analgesic, and still has some limited application in herbal medicine. (L1235). The toxic effects of Aconitine have been tested in a variety of different test animals, including mammals (dog, cat, guinea pig, mouse, rat and rabbit), frogs and pigeons. Depending on the route of exposure, the observed toxic effects were: local anesthetic effect, diarrhea, convulsions, arrhythmias or death. According to a review of different reports of aconite poisoning in humans the following clinical features were observed: Neurological, Cardiovascular, Ventricular arrhythmias, Gastrointestinal. A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties. See also: Aconitum coreanum root (part of). Origin: Plant; SubCategory_DNP: Terpenoid alkaloids, Diterpene alkaloid, Aconitum alkaloid Annotation level-1 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2309
Zongorine
Songorine is a kaurane diterpenoid. Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1]. Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1]. Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1].
(R)-Higenamine
(RS)-norcoclaurine is a norcoclaurine. It is a conjugate base of a (RS)-norcoclaurinium. Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects). Higenamine is a natural product found in Delphinium caeruleum, Aconitum triphyllum, and other organisms with data available. (R)-Higenamine is found in coffee and coffee products. (R)-Higenamine is an alkaloid from the seed embryo of Nelumbo nucifera (East India lotus). D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents D020011 - Protective Agents > D002316 - Cardiotonic Agents D000893 - Anti-Inflammatory Agents D050299 - Fibrin Modulating Agents D002317 - Cardiovascular Agents D018501 - Antirheumatic Agents
Hypaconitine
Hypaconitine is a diterpenoid. Hypaconitine is a natural product found in Aconitum japonicum, Aconitum firmum, and other organisms with data available. Annotation level-1 Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value: Target: In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1]. In vivo: Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value: Target: In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1]. In vivo:
Neoline
Neoline. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=466-26-2 (retrieved 2024-07-24) (CAS RN: 466-26-2). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0). Neoline,?the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1]. Neoline,?the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1].
Neoline
A diterpene alkaloid with formula C24H39NO6 that is isolated from several Aconitum species. Neoline is a natural product found in Aconitum variegatum, Aconitum karakolicum, and other organisms with data available. Neoline,?the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1]. Neoline,?the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1].
Higenamine
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents D020011 - Protective Agents > D002316 - Cardiotonic Agents D000893 - Anti-Inflammatory Agents D050299 - Fibrin Modulating Agents D002317 - Cardiovascular Agents D018501 - Antirheumatic Agents