NCBI Taxonomy: 92908
Cousinia (ncbi_taxid: 92908)
found 64 associated metabolites at genus taxonomy rank level.
Ancestor: Arctiinae
Child Taxonomies: Cousinia nana, Cousinia alata, Cousinia dubia, Cousinia ninae, Cousinia olgae, Cousinia arida, Cousinia elata, Cousinia aurea, Cousinia fursei, Cousinia ariana, Cousinia crispa, Cousinia gaubae, Cousinia lanata, Cousinia lepida, Cousinia albida, Cousinia oopoda, Cousinia oxiana, Cousinia hamosa, Cousinia lucida, Cousinia aptera, Cousinia rigida, Cousinia armena, Cousinia mollis, Cousinia barbeyi, Cousinia freynii, Cousinia grantii, Cousinia iranica, Cousinia lurorum, Cousinia parsana, Cousinia affinis, Cousinia grandis, Cousinia pungens, Cousinia assadii, Cousinia pannosa, Cousinia actinia, Cousinia pusilla, Cousinia radians, Cousinia prasina, Cousinia regelii, Cousinia eugenii, Cousinia foliosa, Cousinia triceps, Cousinia vicaria, Cousinia tenella, Cousinia oophora, Cousinia pygmaea, Cousinia tricolor, Cousinia argentea, Cousinia kotschyi, Cousinia bienerti, Cousinia concinna, Cousinia alfredii, Cousinia autranii, Cousinia badghysi, Cousinia bungeana, Cousinia coerulea, Cousinia concolor, Cousinia greuteri, Cousinia incompta, Cousinia kokanica, Cousinia lamakini, Cousinia meghrica, Cousinia oreodoxa, Cousinia gilanica, Cousinia raddeana, Cousinia araneosa, Cousinia caesarea, Cousinia catenata, Cousinia scariosa, Cousinia sogdiana, Cousinia speciosa, Cousinia congesta, Cousinia coronata, Cousinia erinacea, Cousinia dissecta, Cousinia stocksii, Cousinia euchlora, Cousinia gmelinii, Cousinia hermonis, Cousinia purpurea, Cousinia mogensii, Cousinia rufidula, Cousinia stahliana, Cousinia thomsonii, Cousinia algurdina, Cousinia gilliatii, Cousinia hypopolia, Cousinia mobayenii, Cousinia sahandica, Cousinia denaensis, Cousinia canescens, Cousinia alepideae, Cousinia antonowii, Cousinia apiculata, Cousinia batalinii, Cousinia belangeri, Cousinia crassipes, Cousinia heliantha, Cousinia hypoleuca, Cousinia lasiandra, Cousinia moabitica, Cousinia leucantha, Cousinia multiloba, Cousinia aggregata, Cousinia albescens, Cousinia assyriaca, Cousinia calolepis, Cousinia commutata, Cousinia polyneura, Cousinia prolifera, Cousinia wendelboi, Cousinia neubaueri, Cousinia decipiens, Cousinia decumbens, Cousinia decurrens, Cousinia smirnowii, Cousinia splendida, Cousinia spryginii, Cousinia eriobasis, Cousinia submutica, Cousinia freitagii, Cousinia thamnodes, Cousinia hergtiana, Cousinia komarovii, Cousinia novissima, Cousinia parviceps, Cousinia pulchella, Cousinia pycnoloba, Cousinia recurvata, Cousinia rhabdodes, Cousinia tenuispina, Cousinia tirinensis, Cousinia vvedenskyi, Cousinia cynaroides, Cousinia gaharensis, Cousinia renominata, Cousinia kirrindica, Cousinia kornhuberi, Cousinia lactiflora, Cousinia subinflata, Cousinia auriculata, Cousinia birandiana, Cousinia eriophylla, Cousinia ferruginea, Cousinia franchetii, Cousinia harazensis, Cousinia hastifolia, Cousinia heteroloba, Cousinia intertexta, Cousinia jassyensis, Cousinia lasiolepis, Cousinia leptolepis, Cousinia longifolia, Cousinia macroptera, Cousinia bijarensis, Cousinia pineticola, Cousinia podophylla, Cousinia eriorrhiza, Cousinia glaucopsis, Cousinia tabrisiana, Cousinia calcitrapa, Cousinia yasujensis, Cousinia semilacera, Cousinia shahvarica, Cousinia divaricata, Cousinia caespitosa, Cousinia chrysantha, Cousinia tenuifolia, Cousinia fragillima, Cousinia tenuisecta, Cousinia microcarpa, Cousinia gnezdilloi, Cousinia platylepis, Cousinia urumiensis, Cousinia malurensis, Cousinia margaritae, Cousinia myriolepis, Cousinia orthoclada, Cousinia pergamacea, Cousinia seidlitzii, Cousinia takhtajanii, Cousinia trachylepis, Cousinia sewertzowii, Cousinia shebliensis, Cousinia dalahuensis, Cousinia disfulensis, Cousinia elwendensis, Cousinia lurestanica, Cousinia behboudiana, Cousinia calocephala, Cousinia esfandiarii, Cousinia keredjensis, Cousinia adenosticta, Cousinia brachyptera, Cousinia candolleana, Cousinia chionophila, Cousinia knorringiae, Cousinia cylindracea, Cousinia eryngioides, Cousinia linczewskii, Cousinia bachtiarica, Cousinia pugionifera, Cousinia aitchisonii, Cousinia qaisarensis, Cousinia archibaldii, Cousinia nujianensis, Cousinia rigidissima, Cousinia wilhelminae, Cousinia salangensis, Cousinia arachnoidea, Cousinia astracanica, Cousinia edmondsonii, Cousinia elephantina, Cousinia ferganensis, Cousinia pterocaulos, Cousinia tenuiramula, Cousinia minkwitziae, Cousinia polycephala, Cousinia turcomanica, Cousinia turkmenorum, Cousinia xiphiolepis, Cousinia nekarmanica, Cousinia orthacantha, Cousinia zardkuhensis, Cousinia hamadanensis, Cousinia daryoushiana, Cousinia stenocephala, Cousinia kurdistanica, Cousinia platyacantha, Cousinia bornmuelleri, unclassified Cousinia, Cousinia farsistanica, Cousinia alexeenkoana, Cousinia chrysochlora, Cousinia dipterocarpa, Cousinia ecbatanensis, Cousinia gigantolepis, Cousinia heterophylla, Cousinia macrocephala, Cousinia millefontana, Cousinia oligocephala, Cousinia polytimetica, Cousinia actinacantha, Cousinia andarabensis, Cousinia manouchehrii, Cousinia microcephala, Cousinia carthamoides, Cousinia chitralensis, Cousinia sclerophylla, Cousinia chlorothyrsa, Cousinia piptocephala, Cousinia syrdarjensis, Cousinia leptocephala, Cousinia xanthacantha, Cousinia tianschanica, Cousinia megalomastix, Cousinia myrioglochis, Cousinia pseudactinia, Cousinia pseudomollis, Cousinia serawschanica, Cousinia verticillaris, Cousinia lordeganensis, Cousinia phyllocephala, Cousinia sardashtensis, Cousinia verbascifolia, Cousinia sanandajensis, Cousinia shulabadensis, Cousinia onopordioides, Cousinia chaetocephala, Cousinia chlorocephala, Cousinia daralaghezica, Cousinia dolichophylla, Cousinia gatchsaranica, Cousinia lachnosphaera, Cousinia iranshahriana, Cousinia rechingerorum, Cousinia sarawschanica, Cousinia haussknechtii, Cousinia pinarocephala, Cousinia raphiocephala, Cousinia caroli-henrici, Cousinia aligudarzensis, Cousinia albertoregelia, Cousinia arctotidifolia, Cousinia botschantzevii, Cousinia buphthalmoides, Cousinia tashkurghanica, Cousinia mindshelkensis, Cousinia stechmanniopsis, Cousinia strobilocephala, Cousinia immitantiformis, Cousinia outichaschensis, Cousinia cylindrocephala, Cousinia trachyphyllaria, Cousinia hymenostephanus, Cousinia porphyrochrysea, Cousinia khorramabadensis, Cousinia oshtorankuhensis, Cousinia shahvarica x Cousinia decumbens, Cousinia chrysochlora x Cousinia eryngioides
Cynaropicrin
Constituent of Cynara scolymus (artichoke). Cynaropicrin is found in cardoon, globe artichoke, and root vegetables. Cynaropicrin is found in cardoon. Cynaropicrin is a constituent of Cynara scolymus (artichoke). Cynaropicrin is a sesquiterpene lactone. Cynaropicrin is a natural product found in Pleiotaxis rugosa, Pseudostifftia kingii, and other organisms with data available. See also: Cynara scolymus leaf (part of). D009676 - Noxae > D003603 - Cytotoxins Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
Ursolic acid
Ursolic acid is a ubiquitous triterpenoid in plant kingdom, medicinal herbs, and is an integral part of the human diet. During the last decade over 700 research articles have been published on triterpenoids research, reflecting tremendous interest and progress in our understanding of these compounds. This included the isolation and purification of these tritepernoids from various plants and herbs, the chemical modifications to make more effective and water soluble derivatives, the pharmacological research on their beneficial effects, the toxicity studies, and the clinical use of these triterpenoids in various diseases including anticancer chemotherapies. Ursolic acid (UA), a pentacyclic triterpene acid, has been isolated from many kinds of medicinal plants, such as Eriobotrya japonica, Rosmarinns officinalis, Melaleuca leucadendron, Ocimum sanctum and Glechoma hederaceae. UA has been reported to produce antitumor activities and antioxidant activity, and is reported to have an antioxidant activity. UA may play an important role in regulating the apoptosis induced by high glucose presumably through scavenging of ROS (reactive oxygen species). It has been found recently that ursolic acid treatment affects growth and apoptosis in cancer cells. (PMID: 15994040, 17516235, 17213663). Ursolic acid is a pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3. It has a role as a plant metabolite and a geroprotector. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It derives from a hydride of an ursane. Ursolic acid is a natural product found in Gladiolus italicus, Freziera, and other organisms with data available. Ursolic Acid is a pentacyclic triterpenoid found in various fruits, vegetables and medicinal herbs, with a variety of potential pharmacologic activities including anti-inflammatory, antioxidative, antiviral, serum lipid-lowering, and antineoplastic activities. Upon administration, ursolic acid may promote apoptosis and inhibit cancer cell proliferation through multiple mechanisms. This may include the regulation of mitochondrial function through various pathways including the ROCK/PTEN and p53 pathways, the suppression of the nuclear factor-kappa B (NF-kB) pathways, and the increase in caspase-3, caspase-8 and caspase-9 activities. See also: Holy basil leaf (part of); Jujube fruit (part of); Lagerstroemia speciosa leaf (part of). D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3. C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent Found in wax of apples, pears and other fruits. V. widely distributed in plants D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C26170 - Protective Agent > C275 - Antioxidant D000893 - Anti-Inflammatory Agents D000890 - Anti-Infective Agents D000970 - Antineoplastic Agents D004791 - Enzyme Inhibitors 3-Epiursolic Acid is a triterpenoid that can be isolated from Eriobotrya japonica, acts as a competitive inhibitor of cathepsin L (IC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B[1]. 3-Epiursolic Acid is a triterpenoid that can be isolated from Eriobotrya japonica, acts as a competitive inhibitor of cathepsin L (IC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B[1]. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
Lupeol
Lupeol is a pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables. It has a role as an anti-inflammatory drug and a plant metabolite. It is a secondary alcohol and a pentacyclic triterpenoid. It derives from a hydride of a lupane. Lupeol has been investigated for the treatment of Acne. Lupeol is a natural product found in Ficus auriculata, Ficus septica, and other organisms with data available. See also: Calendula Officinalis Flower (part of). A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables. D000893 - Anti-Inflammatory Agents Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1]. Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1].
beta-Sitosterol 3-O-beta-D-galactopyranoside
Daucosterol is a steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa. It has a role as a plant metabolite. It is a steroid saponin, a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a sitosterol. It derives from a hydride of a stigmastane. Sitogluside is a natural product found in Ophiopogon intermedius, Ophiopogon jaburan, and other organisms with data available. beta-Sitosterol 3-O-beta-D-galactopyranoside is found in herbs and spices. beta-Sitosterol 3-O-beta-D-galactopyranoside is a constituent of Hibiscus sabdariffa (roselle) leaves. C308 - Immunotherapeutic Agent Daucosterol is a natural sterol compound. Daucosterol is a natural sterol compound.
Lappaol D
Lappaol d is a member of the class of compounds known as 2-arylbenzofuran flavonoids. 2-arylbenzofuran flavonoids are phenylpropanoids containing the 2-phenylbenzofuran moiety. Lappaol d is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Lappaol d can be found in burdock, which makes lappaol d a potential biomarker for the consumption of this food product. Lappaol A is a member of benzofurans. 2(3H)-Furanone, 4-(((2S,3R)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-5-benzofuranyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)- is a natural product found in Saussurea macrota, Centaurea napifolia, and other organisms with data available. See also: Arctium lappa fruit (part of).
Amyrin
Beta-amyrin is a pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants. It has a role as a plant metabolite and an Aspergillus metabolite. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an oleanane. beta-Amyrin is a natural product found in Ficus pertusa, Ficus septica, and other organisms with data available. See also: Calendula Officinalis Flower (part of); Viburnum opulus bark (part of); Centaurium erythraea whole (part of). A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants. β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1]. β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1].
Secoisolariciresinol
Secoisolariciresinol, also known as knotolan or secoisolariciresinol, (r*,s*)-isomer, is a member of the class of compounds known as dibenzylbutanediol lignans. Dibenzylbutanediol lignans are lignan compounds containing a 2,3-dibenzylbutane-1,4-diol moiety. Secoisolariciresinol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Secoisolariciresinol can be found in a number of food items such as grape, saskatoon berry, asparagus, and sweet potato, which makes secoisolariciresinol a potential biomarker for the consumption of these food products. Secoisolariciresinol can be found primarily in urine. Secoisolariciresinol is a lignan, a type of phenylpropanoid. It is present in the water extract of silver fir wood, where its content is more than 5 \\\\% . (-)-secoisolariciresinol is an enantiomer of secoisolariciresinol having (-)-(2R,3R)-configuration. It has a role as an antidepressant, a plant metabolite and a phytoestrogen. It is an enantiomer of a (+)-secoisolariciresinol. Secoisolariciresinol has been used in trials studying the prevention of Breast Cancer. Secoisolariciresinol is a natural product found in Fitzroya cupressoides, Crossosoma bigelovii, and other organisms with data available. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens Secoisolariciresinol is a lignan, a type of phenylpropanoids. Secoisolariciresinol is a lignan, a type of phenylpropanoids. Secoisolariciresinol is a lignan, a type of phenylpropanoids.
Epi-alpha-amyrin
Alpha-amyrin is a pentacyclic triterpenoid that is ursane which contains a double bond between positions 12 and 13 and in which the hydrogen at the 3beta position is substituted by a hydroxy group. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an ursane. alpha-Amyrin is a natural product found in Ficus septica, Ficus virens, and other organisms with data available. See also: Calendula Officinalis Flower (part of); Viburnum opulus bark (part of); Eupatorium perfoliatum whole (part of) ... View More ... Carissol is found in beverages. Carissol is a constituent of Carissa carandas (karanda). Constituent of Carissa carandas (karanda). Carissol is found in beverages and fruits.
(-)-Arctigenin
(-)-Arctigenin is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD).Arctigenin is a lignan found in certain plants of the Asteraceae , including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin. (Wikipedia (-)-Arctigenin is a lignan. Arctigenin is a natural product found in Centaurea cineraria, Forsythia suspensa, and other organisms with data available. See also: Arctium lappa Root (part of); Arctium lappa fruit (part of); Pumpkin Seed (part of) ... View More ... Isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD) Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3]. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].
Taraxasterol
Constituent of dandelion roots (Taraxacum officinale), Roman chamomile flowers (Anthemis nobilis) and many other plants. Taraxasterol is found in many foods, some of which are soy bean, chicory, evening primrose, and common grape. Taraxasterol is found in alcoholic beverages. Taraxasterol is a constituent of dandelion roots (Taraxacum officinale), Roman chamomile flowers (Anthemis nobilis) and many other plants Taraxasterol is a pentacyclic triterpenoid isolated from Taraxacum mongolicum. Taraxasterol has a role as a metabolite and an anti-inflammatory agent[1]. Taraxasterol is a pentacyclic triterpenoid isolated from Taraxacum mongolicum. Taraxasterol has a role as a metabolite and an anti-inflammatory agent[1].
Pinoresinol
4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol is a natural product found in Zanthoxylum riedelianum, Forsythia suspensa, and other organisms with data available. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2]. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2].
Lappaol A
Lappaol a is a member of the class of compounds known as 2-arylbenzofuran flavonoids. 2-arylbenzofuran flavonoids are phenylpropanoids containing the 2-phenylbenzofuran moiety. Lappaol a is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Lappaol a can be found in burdock, which makes lappaol a a potential biomarker for the consumption of this food product.
Taraxasterol
Taraxasterol is a pentacyclic triterpenoid that is taraxastane with a beta-hydroxy group at position 3. It has a role as a metabolite and an anti-inflammatory agent. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of a taraxastane. Taraxasterol is a natural product found in Eupatorium altissimum, Eupatorium perfoliatum, and other organisms with data available. See also: Calendula Officinalis Flower (part of). A pentacyclic triterpenoid that is taraxastane with a beta-hydroxy group at position 3. Taraxasterol is a pentacyclic triterpenoid isolated from Taraxacum mongolicum. Taraxasterol has a role as a metabolite and an anti-inflammatory agent[1]. Taraxasterol is a pentacyclic triterpenoid isolated from Taraxacum mongolicum. Taraxasterol has a role as a metabolite and an anti-inflammatory agent[1].
Ursolic Acid
Origin: Plant; SubCategory_DNP: Triterpenoids relative retention time with respect to 9-anthracene Carboxylic Acid is 1.636 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.640 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.638 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.642 Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
Virgatic acid
A pentacyclic triterpenoid that is olean-12-ene substituted by a carboxy group at position 28, a beta-hydroxy group at position 3 and an oxo group at position 1. It has been isolated from Juglans sinensis.
lupeol
D000893 - Anti-Inflammatory Agents Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1]. Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1].
Cynaropicrin
Cynaropicrin is a sesquiterpene lactone. Cynaropicrin is a natural product found in Pleiotaxis rugosa, Pseudostifftia kingii, and other organisms with data available. See also: Cynara scolymus leaf (part of). D009676 - Noxae > D003603 - Cytotoxins Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
3,4-Bis[[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxybenzofuran-5-yl]methyl]-4,5-dihydrofuran-2(3H)-one
Daucosterol
Daucosterol is a steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa. It has a role as a plant metabolite. It is a steroid saponin, a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a sitosterol. It derives from a hydride of a stigmastane. Sitogluside is a natural product found in Ophiopogon intermedius, Ophiopogon jaburan, and other organisms with data available. A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa. C308 - Immunotherapeutic Agent Daucosterol is a natural sterol compound. Daucosterol is a natural sterol compound.
Urson
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C26170 - Protective Agent > C275 - Antioxidant D000893 - Anti-Inflammatory Agents D000890 - Anti-Infective Agents D000970 - Antineoplastic Agents D004791 - Enzyme Inhibitors Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
viminalol
Alpha-amyrin is a pentacyclic triterpenoid that is ursane which contains a double bond between positions 12 and 13 and in which the hydrogen at the 3beta position is substituted by a hydroxy group. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an ursane. alpha-Amyrin is a natural product found in Ficus septica, Ficus virens, and other organisms with data available. See also: Calendula Officinalis Flower (part of); Viburnum opulus bark (part of); Eupatorium perfoliatum whole (part of) ... View More ...
