Lupenone

1,2,5,14,18,18-hexamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicosan-17-one

C30H48O (424.37049579999996)


1,2,5,14,18,18-hexamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicosan-17-one belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. 1,2,5,14,18,18-hexamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicosan-17-one is an extremely weak basic (essentially neutral) compound (based on its pKa). This compound has been identified in human blood as reported by (PMID: 31557052 ). Lupenone is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically Lupenone is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.

   

Lupenone

(1R,3aR,4S,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-1-Isopropenyl-3a,5a,5b,8,8,11a-hexamethyl-eicosahydro-cyclopenta[a]chrysen-9-one

C30H48O (424.37049579999996)


Lupenone, isolated from Musa basjoo, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity[1][2]. Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities[1][2][3]. Lupenone, isolated from Musa basjoo, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity[1][2].

   

ent-Kaur-16-en-19-oic acid

ent-Kaur-16-en-19-oic acid

C20H30O2 (302.224568)


   

Vanillyl alcohol

4-(Hydroxymethyl)-2-methoxyphenol

C8H10O3 (154.062991)


Vanillyl alcohol (p-(Hydroxymethyl)guaiacol), derived from vanillin, is a phenolic alcohol and is used as a flavoring agent in foods and beverages[1]. Vanillyl alcohol (p-(Hydroxymethyl)guaiacol), derived from vanillin, is a phenolic alcohol and is used as a flavoring agent in foods and beverages[1].

   

(1S,2E,10R)-3,7,11,11-tetramethylbicyclo[8.1.0]undeca-2,6-diene

(1S,2E,10R)-3,7,11,11-tetramethylbicyclo[8.1.0]undeca-2,6-diene

C15H24 (204.18779039999998)


   

4-{[2,2'-bithiophen]-5-yl}but-3-yne-1,2-diol

4-{[2,2'-bithiophen]-5-yl}but-3-yne-1,2-diol

C12H10O2S2 (250.01222)


   

(2e,6e)-3,7,11,11-tetramethylbicyclo[8.1.0]undeca-2,6-diene

(2e,6e)-3,7,11,11-tetramethylbicyclo[8.1.0]undeca-2,6-diene

C15H24 (204.18779039999998)


   

4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol

4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol

C30H48O (424.37049579999996)


   

4-{[(2e)-5-[(1r)-2,2-dimethyl-6-methylidene-3-oxocyclohexyl]-3-methylpent-2-en-1-yl]oxy}-5-methylchromen-2-one

4-{[(2e)-5-[(1r)-2,2-dimethyl-6-methylidene-3-oxocyclohexyl]-3-methylpent-2-en-1-yl]oxy}-5-methylchromen-2-one

C25H30O4 (394.214398)


   

10-methyl-4-methylidene-2h,3h-pyrano[3,2-c]chromen-5-one

10-methyl-4-methylidene-2h,3h-pyrano[3,2-c]chromen-5-one

C14H12O3 (228.0786402)


   

4-ethenyl-2-hydroxy-4,10-dimethyl-2-[3-methyl-3-(4-methylpent-3-en-1-yl)oxiran-2-yl]-3h-pyrano[3,2-c]chromen-5-one

4-ethenyl-2-hydroxy-4,10-dimethyl-2-[3-methyl-3-(4-methylpent-3-en-1-yl)oxiran-2-yl]-3h-pyrano[3,2-c]chromen-5-one

C25H30O5 (410.209313)


   

4,10-dimethyl-2h-pyrano[3,2-c]chromen-5-one

4,10-dimethyl-2h-pyrano[3,2-c]chromen-5-one

C14H12O3 (228.0786402)


   

1,1,4a-trimethyl-6-methylidene-5-(4-methylpent-3-en-1-yl)-hexahydro-2h-naphthalen-2-ol

1,1,4a-trimethyl-6-methylidene-5-(4-methylpent-3-en-1-yl)-hexahydro-2h-naphthalen-2-ol

C20H34O (290.2609514)


   

(2e)-3-(3-methoxy-4-{[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy}phenyl)prop-2-en-1-ol

(2e)-3-(3-methoxy-4-{[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy}phenyl)prop-2-en-1-ol

C25H36O3 (384.26643060000004)


   

(7ar)-1,1,7-trimethyl-4-methylidene-octahydrocyclopropa[e]azulen-7-ol

(7ar)-1,1,7-trimethyl-4-methylidene-octahydrocyclopropa[e]azulen-7-ol

C15H24O (220.18270539999997)


   

3-ethenyl-1-(2-hydroxy-6-methylphenyl)-3,7,11-trimethyldodeca-6,10-diene-1,5-dione

3-ethenyl-1-(2-hydroxy-6-methylphenyl)-3,7,11-trimethyldodeca-6,10-diene-1,5-dione

C24H32O3 (368.23513219999995)


   

4-{5'-methyl-[2,2'-bithiophen]-5-yl}but-3-yne-1,2-diol

4-{5'-methyl-[2,2'-bithiophen]-5-yl}but-3-yne-1,2-diol

C13H12O2S2 (264.0278692)


   

(1r,2s,5r,8r)-2,6,6,8-tetramethyltricyclo[6.3.0.0¹,⁵]undecane

(1r,2s,5r,8r)-2,6,6,8-tetramethyltricyclo[6.3.0.0¹,⁵]undecane

C15H26 (206.2034396)


   

(3s,4ar,6ar,6bs,8ar,12r,12ar,14ar,14br)-4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol

(3s,4ar,6ar,6bs,8ar,12r,12ar,14ar,14br)-4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol

C30H48O (424.37049579999996)


   

4-[(6-hydroxy-5,5,8a-trimethyl-2-methylidene-hexahydro-1h-naphthalen-1-yl)methoxy]-5-methylchromen-2-one

4-[(6-hydroxy-5,5,8a-trimethyl-2-methylidene-hexahydro-1h-naphthalen-1-yl)methoxy]-5-methylchromen-2-one

C25H32O4 (396.2300472)