Amyrin (BioDeep_00000000901)

 

Secondary id: BioDeep_00000259010

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(3S,4aR,5R,6aR,6bR,8S,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-Octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-eicosahydro-picen-3-ol

化学式: C30H50O (426.3861)
中文名称: β-香树素, beta-香树精, β-香树脂醇
谱图信息: 最多检出来源 Viridiplantae(plant) 9.77%

分子结构信息

SMILES: CC1(C)CCC2(C)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC43C)C2C1
InChI: InChI=1S/C30H50O/c1-25(2)15-16-27(5)17-18-29(7)20(21(27)19-25)9-10-23-28(6)13-12-24(31)26(3,4)22(28)11-14-30(23,29)8/h9,21-24,31H,10-19H2,1-8H3

描述信息

Beta-amyrin is a pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants. It has a role as a plant metabolite and an Aspergillus metabolite. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an oleanane.
beta-Amyrin is a natural product found in Ficus pertusa, Ficus septica, and other organisms with data available.
See also: Calendula Officinalis Flower (part of); Viburnum opulus bark (part of); Centaurium erythraea whole (part of).
A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.
β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1].
β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1].

同义名列表

38 个代谢物同义名

(3S,4aR,5R,6aR,6bR,8S,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-Octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-eicosahydro-picen-3-ol; (3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-ol; (3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol; beta-Amyrin, analytical standard; JFSHUTJDVKUMTJ-QHPUVITPSA-N; (3-.beta.)-Olean-12-en-3-ol; Olean-12-en-3-ol, (3beta)-; 3beta-hydroxyolean-12-ene; (3beta)-olean-12-en-3-ol; Olean-12-en-3-ol, (3b)-; Olean-12-en-3beta-ol; .BETA.-AMYRIN [MI]; beta.-Amyrenol; beta-Amyrenol; AMYRIN, BETA-; beta.-Amyrin; beta -Amyrin; I(2)-Amyrin; Beta-Amyrin; β-Amyrin; B-Amyrin; -amyrin; Amyrin; Olean-12-en-3-ol, (3beta)- (9CI); EINECS 209-204-6; LMPR01060012; AIDS-058054; 09236_FLUKA; AIDS058054; NSC 527971; ST5309409; 559-70-6; C08616; Olean-12-en-3β-ol; .beta.-Amyrin; β-Amyrin; beta-Amyrin; beta-Amyrin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

42 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(9)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(33)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1862 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ALOX5, CAT, NOS2, PTGS2
Peripheral membrane protein 6 ALOX5, CYP1B1, LSS, MGLL, PTGS2, SQLE
Endoplasmic reticulum membrane 6 CYP1B1, FDFT1, LSS, MGLL, PTGS2, SQLE
Nucleus 2 MPO, NOS2
cytosol 6 ALOX5, CAT, GPT, LIPE, MGLL, NOS2
nucleoplasm 3 ALOX5, MPO, NOS2
Cell membrane 3 LIPE, TNF, TRPV1
Multi-pass membrane protein 2 FDFT1, TRPV1
Synapse 1 TAC1
cell surface 1 TNF
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuronal cell body 3 TAC1, TNF, TRPV1
Cytoplasm, cytosol 4 ALOX5, LIPE, MGLL, NOS2
Lysosome 2 GAA, MPO
plasma membrane 6 GAA, KNG1, MGLL, NOS2, TNF, TRPV1
Membrane 9 CAT, CYP1B1, FDFT1, GAA, LIPE, LSS, MGLL, SQLE, TRPV1
axon 1 TAC1
caveola 2 LIPE, PTGS2
extracellular exosome 5 CAT, GAA, GPT, KNG1, MPO
Lysosome membrane 1 GAA
endoplasmic reticulum 3 FDFT1, PTGS2, SQLE
extracellular space 8 ALOX5, IL10, IL6, INS, KNG1, MPO, TAC1, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ALOX5, NOS2
mitochondrion 2 CAT, CYP1B1
protein-containing complex 2 CAT, PTGS2
intracellular membrane-bounded organelle 5 CAT, CYP1B1, GAA, MPO, SQLE
Microsome membrane 3 CYP1B1, PTGS2, SQLE
Secreted 4 GAA, IL10, IL6, INS
extracellular region 10 ALOX5, CAT, GAA, IL10, IL6, INS, KNG1, MPO, TAC1, TNF
mitochondrial matrix 1 CAT
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 2 TNF, TRPV1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 TRPV1
Cytoplasm, perinuclear region 2 ALOX5, NOS2
Membrane raft 1 TNF
focal adhesion 1 CAT
GABA-ergic synapse 1 TRPV1
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 MPO
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 TRPV1
Cell projection, neuron projection 1 TRPV1
neuron projection 1 PTGS2
phagocytic cup 1 TNF
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
endosome lumen 1 INS
Lipid droplet 2 LIPE, LSS
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 ALOX5, CAT
secretory granule lumen 3 ALOX5, CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 IL6, INS, KNG1, PTGS2
nuclear matrix 1 ALOX5
platelet alpha granule lumen 1 KNG1
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
phagocytic vesicle lumen 1 MPO
ficolin-1-rich granule membrane 1 GAA
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
Nucleus intermembrane space 1 ALOX5
autolysosome lumen 1 GAA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Sara Zahid, Arif Malik, Suleyman Waqar, Fatima Zahid, Nusrat Tariq, Ali Imran Khawaja, Waqas Safir, Faisal Gulzar, Javeid Iqbal, Qurban Ali. Countenance and implication of Β-sitosterol, Β-amyrin and epiafzelechin in nickel exposed Rat: in-silico and in-vivo approach. Scientific reports. 2023 12; 13(1):21351. doi: 10.1038/s41598-023-48772-4. [PMID: 38049552]
  • Opeyemi Josephine Akinmurele, Mubo Adeola Sonibare, Anthony A Elujoba, Akingbolabo Daniel Ogunlakin, Oloruntoba Emmanuel Yeye, Gideon Ampoma Gyebi, Oluwafemi Adeleke Ojo, Abdullah R Alanzi. Antispasmodic Effect of Alstonia boonei De Wild. and Its Constituents: Ex Vivo and In Silico Approaches. Molecules (Basel, Switzerland). 2023 Oct; 28(20):. doi: 10.3390/molecules28207069. [PMID: 37894548]
  • Jinling Li, Shuai Wang, Yinan Miao, Ya Wan, Chun Li, Ying Wang. Mining and modification of Oryza sativa-derived squalene epoxidase for improved β-amyrin production in Saccharomyces cerevisiae. Journal of biotechnology. 2023 Aug; 375(?):1-11. doi: 10.1016/j.jbiotec.2023.08.004. [PMID: 37597655]
  • Mona Raslan, Marwa M Mounier. Phytochemical profiling and compound isolation of Cissus rhombifolia Vahl. leaves aqueous methanolic extract with the evaluation of its anti-inflammatory effect using lipopolysaccharide-induced inflammation in RAW 264.7 cells. Chemistry & biodiversity. 2023 May; ?(?):e202300307. doi: 10.1002/cbdv.202300307. [PMID: 37204915]
  • Han-Bin Choi, Sangrea Shim, Myeong-Hyeon Wang, Yong-Eui Choi. De Novo Transcriptome Sequencing of Codonopsis lanceolata for Identification of Triterpene Synthase and Triterpene Acetyltransferase. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065769. [PMID: 36982844]
  • Mengchu Sun, Qi Xin, Kangxin Hou, Jie Qiu, Linmei Wang, Erkun Chao, Xinyao Su, Xiuxin Zhang, Shilin Chen, Caixia Wang. Production of 11-Oxo-β-Amyrin in Saccharomyces cerevisiae at High Efficiency by Fine-Tuning the Expression Ratio of CYP450:CPR. Journal of agricultural and food chemistry. 2023 Feb; ?(?):. doi: 10.1021/acs.jafc.2c08261. [PMID: 36795896]
  • Ying Zhu, Chen Zhou, Xia Liu, Xinying Li, Caifang Shi, Yapeng Zhang, Ying Wang, Chun Li. Aided-efflux and high production of β-amyrin realized by β-cyclodextrin in situ synthesized on surface of Saccharomyces cerevisiae. Biotechnology and bioengineering. 2023 Jan; ?(?):. doi: 10.1002/bit.28327. [PMID: 36593696]
  • Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn, Xue Qiao. Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function. Journal of advanced research. 2023 01; 43(?):247-257. doi: 10.1016/j.jare.2022.03.014. [PMID: 36585112]
  • Hai-Yun Gao, Long-Long Gao, Yuan Liu, Huan Zhao, Wei Gao. [Cloning and functional characterization of two oxidosqualene cyclase genes from Siraitia grosvenorii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Nov; 47(22):6050-6057. doi: 10.19540/j.cnki.cjcmm.20220713.102. [PMID: 36471929]
  • Md Amjad Beg, Shivangi, Obaid Afzal, Md Sayeed Akhtar, Abdulmalik S A Altamimi, Afzal Hussain, Md Ali Imam, Mohammad Naiyaz Ahmad, Sidharth Chopra, Fareeda Athar. Potential Efficacy of β-Amyrin Targeting Mycobacterial Universal Stress Protein by In Vitro and In Silico Approach. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144581. [PMID: 35889451]
  • Wenhua Xu, Hongwu Zhang, Qinfeng Zhang, Jialan Xu. β-Amyrin ameliorates diabetic nephropathy in mice and regulates the miR-181b-5p/HMGB2 axis in high glucose-stimulated HK-2 cells. Environmental toxicology. 2022 Mar; 37(3):637-649. doi: 10.1002/tox.23431. [PMID: 34894065]
  • Tran Duc Viet, Tran Dang Xuan, La Hoang Anh. α-Amyrin and β-Amyrin Isolated from Celastrus hindsii Leaves and Their Antioxidant, Anti-Xanthine Oxidase, and Anti-Tyrosinase Potentials. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237248. [PMID: 34885832]
  • Bruna F Mazzeu, Tatiana M Souza-Moreira, Andrew A Oliveira, Melissa Remlinger, Lidiane G Felippe, Sandro R Valentini, Rafael V C Guido, Cleslei F Zanelli, Maysa Furlan. The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226806. [PMID: 34833897]
  • Do Tien Lam, Vu Thi Thu Le, Pham Minh Quan, Pham Thi Hong Minh, Ta Thi Thu Thuy, Nguyen Thi Ngoc Anh, Bui Huu Tai, Phan Van Kiem. Two new terpenoids from the leaves of callicarpa macrophylla. Natural product research. 2021 Apr; 35(7):1107-1114. doi: 10.1080/14786419.2019.1639180. [PMID: 31303054]
  • Nan Qin, Xin Lu, Yijun Liu, Yuting Qiao, Wei Qu, Feng Feng, Haopeng Sun. Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry. European journal of medicinal chemistry. 2021 Jan; 210(?):112960. doi: 10.1016/j.ejmech.2020.112960. [PMID: 33148492]
  • R P de Lima, P I G Nunes, A F S C Viana, F T B de Oliveira, R A C Silva, A P N N Alves, D A Viana, S G C Fonseca, A A Carvalho, M H Chaves, V S Rao, F A Santos. α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2021; 54(10):e11391. doi: 10.1590/1414-431x2021e11391. [PMID: 34406209]
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  • Jian Wang, Hui-Xin Lin, Huan Zhao, Juan Guo, Ping Su, Jian Yang, Xiao-Yi Wu, Lu-Qi Huang, Wei Gao. Molecular cloning and functional characterization of multiple ApOSCs from Andrographis paniculata. Chinese journal of natural medicines. 2020 Sep; 18(9):659-665. doi: 10.1016/s1875-5364(20)60004-8. [PMID: 32928509]
  • E A Hashish, S A Elgaml, Aha El-Fattah, S I Shalaby, S Abdelaziz. β-Amyrin supplementation ameliorates the toxic effect of glycerol in the kidney of rat model. Human & experimental toxicology. 2020 Jul; 39(7):930-937. doi: 10.1177/0960327120907136. [PMID: 32081053]
  • Bruna Karen Cardoso, Herika Line Marko de Oliveira, Ulisses Zonta Melo, Carla Maria Mariano Fernandez, Caio Franco de Araújo Almeida Campo, José Eduardo Gonçalves, Antônio Laverde, Mariza Barion Romagnolo, Giani Andrea Linde, Zilda Cristiani Gazim. Antioxidant activity of α and β-amyrin isolated from Myrcianthes pungens leaves. Natural product research. 2020 Jun; 34(12):1777-1781. doi: 10.1080/14786419.2018.1525715. [PMID: 30465617]
  • Isaac T Henneh, Boshi Huang, Faik N Musayev, Rana Al Hashimi, Martin K Safo, Francis A Armah, Elvis O Ameyaw, Christian K Adokoh, Martins Ekor, Yan Zhang. Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae). Bioorganic chemistry. 2020 05; 98(?):103744. doi: 10.1016/j.bioorg.2020.103744. [PMID: 32179280]
  • Gari Vidal Ccana-Ccapatinta, Jennyfer Andrea Aldana Mejía, Matheus Hikaru Tanimoto, Milton Groppo, Jean Carlos Andrade Sarmento de Carvalho, Jairo Kenupp Bastos. Dalbergia ecastaphyllum (L.) Taub. and Symphonia globulifera L.f.: The Botanical Sources of Isoflavonoids and Benzophenones in Brazilian Red Propolis. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092060. [PMID: 32354180]
  • Matthew P Dale, Tessa Moses, Emily J Johnston, Susan J Rosser. A systematic comparison of triterpenoid biosynthetic enzymes for the production of oleanolic acid in Saccharomyces cerevisiae. PloS one. 2020; 15(5):e0231980. doi: 10.1371/journal.pone.0231980. [PMID: 32357188]
  • Fu-Sheng Zhang, Xuan Zhang, Qian-Yu Wang, Ya-Jie Pu, Chen-Hui Du, Xue-Mei Qin, Hong-Ling Tian, Yun-Lan Lian, Min-Sheng Li, Yu Chen, Cun-Gen Ma. Cloning, Yeast Expression, and Characterization of a β-Amyrin C-28 Oxidase (CYP716A249) Involved in Triterpenoid Biosynthesis in Polygala tenuifolia. Biological & pharmaceutical bulletin. 2020; 43(12):1839-1846. doi: 10.1248/bpb.b20-00343. [PMID: 33268701]
  • Garima Ayachit, Inayatullah Shaikh, Preeti Sharma, Bhavika Jani, Labdhi Shukla, Priyanka Sharma, Shivarudrappa B Bhairappanavar, Chaitanya Joshi, Jayashankar Das. De novo transcriptome of Gymnema sylvestre identified putative lncRNA and genes regulating terpenoid biosynthesis pathway. Scientific reports. 2019 10; 9(1):14876. doi: 10.1038/s41598-019-51355-x. [PMID: 31619732]
  • Ueveton Pimentel da Silva, Gabriela Milane Furlani, Antônio Jacinto Demuner, Otávio Luis Marques da Silva, Eduardo Vinícius Vieira Varejão. Allelopathic activity and chemical constituents of extracts from roots of Euphorbia heterophylla L. Natural product research. 2019 Sep; 33(18):2681-2684. doi: 10.1080/14786419.2018.1460829. [PMID: 29629832]
  • Zhixue Wu, Hui Xu, Meiling Wang, Ruoting Zhan, Weiwen Chen, Ren Zhang, Zaoyuan Kuang, Fengxue Zhang, Kui Wang, Jiangyong Gu. Molecular Docking and Molecular Dynamics Studies on Selective Synthesis of α-Amyrin and β-Amyrin by Oxidosqualene Cyclases from Ilex Asprella. International journal of molecular sciences. 2019 Jul; 20(14):. doi: 10.3390/ijms20143469. [PMID: 31311103]
  • Ali M El-Halawany, Samir M Osman, Hossam M Abdallah. Cytotoxic constituents from Vicia monantha subsp. monantha seeds. Natural product research. 2019 Jun; 33(12):1783-1786. doi: 10.1080/14786419.2018.1434638. [PMID: 29411647]
  • Hu Liu, Jingjing Fan, Chen Wang, Chun Li, Xiaohong Zhou. Enhanced β-Amyrin Synthesis in Saccharomyces cerevisiae by Coupling An Optimal Acetyl-CoA Supply Pathway. Journal of agricultural and food chemistry. 2019 Apr; 67(13):3723-3732. doi: 10.1021/acs.jafc.9b00653. [PMID: 30808164]
  • Meng-Chu Sun, Er-Kun Chao, Xin-Yao Su, Min Zhu, Yong Su, Guang-Tao Qian, Shi-Lin Chen, Cai-Xia Wang, Jian-Ping Xue. [Study of heterologous efficient synthesis of β-amyrin and high-density fermentation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Apr; 44(7):1341-1349. doi: 10.19540/j.cnki.cjcmm.20190129.011. [PMID: 31090290]
  • Abraham Giacoman-Martínez, Francisco J Alarcón-Aguilar, Alejandro Zamilpa, Sergio Hidalgo-Figueroa, Gabriel Navarrete-Vázquez, Rebeca García-Macedo, Rubén Román-Ramos, Julio C Almanza-Pérez. Triterpenoids from Hibiscus sabdariffa L. with PPARδ/γ Dual Agonist Action: In Vivo, In Vitro and In Silico Studies. Planta medica. 2019 Mar; 85(5):412-423. doi: 10.1055/a-0824-1316. [PMID: 30650453]
  • Guo-Yan Mo, Fang Huang, Yin Fang, Lin-Tao Han, Kayla K Pennerman, Li-Jing Bu, Xiao-Wei DU, Joan W Bennett, Guo-Hua Yin. Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones. Chinese journal of natural medicines. 2019 Feb; 17(2):131-144. doi: 10.1016/s1875-5364(19)30015-9. [PMID: 30797419]
  • Amaurilio O Nogueira, Yasmin Ingrid S Oliveira, Beatriz L Adjafre, Maria E Amaral de Moraes, Gislei F Aragão. Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review. Fundamental & clinical pharmacology. 2019 Feb; 33(1):4-12. doi: 10.1111/fcp.12402. [PMID: 30003594]
  • Karina Moura de Melo, Francisca Tuelly Bandeira de Oliveira, Rose Anny Costa Silva, Ana Luiza Gomes Quinderé, José Delano Barreto Marinho Filho, Ana Jérsia Araújo, Eanes Delgado Barros Pereira, Adonias Almeida Carvalho, Mariana Helena Chaves, Vietla Satyanarayana Rao, Flávia Almeida Santos. α, β-Amyrin, a pentacyclic triterpenoid from Protium heptaphyllum suppresses adipocyte differentiation accompanied by down regulation of PPARγ and C/EBPα in 3T3-L1 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):1860-1866. doi: 10.1016/j.biopha.2018.11.027. [PMID: 30551441]
  • Pankajkumar B Nariya, Vinay J Shukla, R N Acharya, Mukeshkumar B Nariya, Jayesh M Dhalani, Anilkumar S Patel, Pratik A Ambasana. Triterpenoid and Fatty Acid Contents from the Stem Bark of Cordia dichotoma (Forst f.). Folia medica. 2018 Dec; 60(4):594-600. doi: 10.2478/folmed-2018-0026. [PMID: 31188773]
  • Yuan Yu, Pengcheng Chang, Huan Yu, Huiyong Ren, Danning Hong, Zeyan Li, Ying Wang, Hao Song, Yixin Huo, Chun Li. Productive Amyrin Synthases for Efficient α-Amyrin Synthesis in Engineered Saccharomyces cerevisiae. ACS synthetic biology. 2018 10; 7(10):2391-2402. doi: 10.1021/acssynbio.8b00176. [PMID: 30216049]
  • Zahra Shirazi, Ali Aalami, Masoud Tohidfar, Mohammad Mehdi Sohani. Metabolic Engineering of Glycyrrhizin Pathway by Over-Expression of Beta-amyrin 11-Oxidase in Transgenic Roots of Glycyrrhiza glabra. Molecular biotechnology. 2018 Jun; 60(6):412-419. doi: 10.1007/s12033-018-0082-7. [PMID: 29687371]
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