Palmitic acid (BioDeep_00000000476)

 

Secondary id: BioDeep_00000229690, BioDeep_00000264842, BioDeep_00000859352

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite PANOMIX LipidSearch BioNovoGene_Lab2019 natural product


代谢物信息卡片


hexadecanoic acid

化学式: C16H32O2 (256.2402)
中文名称: 软脂酸, 棕榈酸, 十六烷酸, 软脂酸; 棕榈酸，十六(烷)酸, 正十六烷酸
谱图信息: 最多检出来源 Homo sapiens(blood) 15.92%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Palmitic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/palmitic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000476). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(=O)O
InChI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

描述信息

Palmitic acid, also known as palmitate or hexadecanoic acid, is a member of the class of compounds known as long-chain fatty acids. Long-chain fatty acids are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms. Thus, palmitic acid is considered to be a fatty acid lipid molecule. Palmitic acid is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Palmitic acid can be found in a number of food items such as sacred lotus, spinach, shallot, and corn salad, which makes palmitic acid a potential biomarker for the consumption of these food products. Palmitic acid can be found primarily in most biofluids, including feces, sweat, cerebrospinal fluid (CSF), and urine, as well as throughout most human tissues. Palmitic acid exists in all living species, ranging from bacteria to humans. In humans, palmitic acid is involved in several metabolic pathways, some of which include alendronate action pathway, rosuvastatin action pathway, simvastatin action pathway, and cerivastatin action pathway. Palmitic acid is also involved in several metabolic disorders, some of which include hypercholesterolemia, familial lipoprotein lipase deficiency, ethylmalonic encephalopathy, and carnitine palmitoyl transferase deficiency (I). Moreover, palmitic acid is found to be associated with schizophrenia. Palmitic acid is a non-carcinogenic (not listed by IARC) potentially toxic compound. Palmitic acid, or hexadecanoic acid in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and microorganisms. Its chemical formula is CH3(CH2)14COOH, and its C:D is 16:0. As its name indicates, it is a major component of the oil from the fruit of oil palms (palm oil). Palmitic acid can also be found in meats, cheeses, butter, and dairy products. Palmitate is the salts and esters of palmitic acid. The palmitate anion is the observed form of palmitic acid at physiologic pH (7.4) . Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced. Palmitate negatively feeds back on acetyl-CoA carboxylase (ACC) which is responsible for converting acetyl-ACP to malonyl-ACP on the growing acyl chain, thus preventing further palmitate generation (DrugBank).
Palmitic acid, or hexadecanoic acid, is one of the most common saturated fatty acids found in animals, plants, and microorganisms. As its name indicates, it is a major component of the oil from the fruit of oil palms (palm oil). Excess carbohydrates in the body are converted to palmitic acid. Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. As a consequence, palmitic acid is a major body component of animals. In humans, one analysis found it to make up 21–30\\\% (molar) of human depot fat (PMID: 13756126), and it is a major, but highly variable, lipid component of human breast milk (PMID: 352132). Palmitic acid is used to produce soaps, cosmetics, and industrial mould release agents. These applications use sodium palmitate, which is commonly obtained by saponification of palm oil. To this end, palm oil, rendered from palm tree (species Elaeis guineensis), is treated with sodium hydroxide (in the form of caustic soda or lye), which causes hydrolysis of the ester groups, yielding glycerol and sodium palmitate. Aluminium salts of palmitic acid and naphthenic acid were combined during World War II to produce napalm. The word "napalm" is derived from the words naphthenic acid and palmitic acid (Wikipedia). Palmitic acid is also used in the determination of water hardness and is a surfactant of Levovist, an intravenous ultrasonic contrast agent.
Hexadecanoic acid is a straight-chain, sixteen-carbon, saturated long-chain fatty acid. It has a role as an EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor, a plant metabolite, a Daphnia magna metabolite and an algal metabolite. It is a long-chain fatty acid and a straight-chain saturated fatty acid. It is a conjugate acid of a hexadecanoate.
A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
Palmitic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Palmitic Acid is a saturated long-chain fatty acid with a 16-carbon backbone. Palmitic acid is found naturally in palm oil and palm kernel oil, as well as in butter, cheese, milk and meat.
Palmitic acid, or hexadecanoic acid is one of the most common saturated fatty acids found in animals and plants, a saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. It occurs in the form of esters (glycerides) in oils and fats of vegetable and animal origin and is usually obtained from palm oil, which is widely distributed in plants. Palmitic acid is used in determination of water hardness and is an active ingredient of *Levovist*TM, used in echo enhancement in sonographic Doppler B-mode imaging and as an ultrasound contrast medium.
A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
A straight-chain, sixteen-carbon, saturated long-chain fatty acid.

Palmitic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=57-10-3 (retrieved 2024-07-01) (CAS RN: 57-10-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

148 个代谢物同义名

Palmitic acid, Pharmaceutical Secondary Standard; Certified Reference Material; Palmitic acid, United States Pharmacopeia (USP) Reference Standard; Palmitic acid, European Pharmacopoeia (EP) Reference Standard; Palmitic acid, certified reference material, TraceCERT(R); PALMITIC ACID (CONSTITUENT OF EVENING PRIMROSE OIL); PALMITIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC]; PALMITIC ACID (CONSTITUENT OF SPIRULINA) [DSC]; PALMITIC ACID (CONSTITUENT OF BORAGE SEED OIL); Hexadecanoic acid 10 microg/mL in Acetonitrile; Palmitic acid, >=98\\% palmitic acid basis (GC); 4-02-00-01157 (Beilstein Handbook Reference); PALMITIC ACID (CONSTITUENT OF FLAX SEED OIL); Palmitic acid, Vetec(TM) reagent grade, 98\\%; PALMITIC ACID (CONSTITUENT OF SAW PALMETTO); PALMITIC ACID (CONSTITUENT OF SPIRULINA); Palmitic acid, SAJ first grade, >=95.0\\%; Palmitic acid, for synthesis, 98.0\\%; BA71C79B-C9B1-451A-A5BE-B480B5CC7D0C; LUCINACTANT COMPONENT PALMITIC ACID; Palmitic acid, purum, >=98.0\\% (GC); Palmitic acid, analytical standard; SURFAXIN COMPONENT PALMITIC ACID; Palmitic acid, natural, 98\\%, FG; HEXADECANOIC-11,11,12,12-D4 ACID; Palmitic acid; Hexadecanoic acid; Hexadecanoic acid Palmitic acid; Palmitic acid, >=95\\%, FCC, FG; Palmitic acid, BioXtra, >=99\\%; Palmitic acid, Grade II, ~95\\%; 1-Pentadecanecarboxylic acid; PALMITIC ACID [EP MONOGRAPH]; PALMITIC ACID (EP MONOGRAPH); (1(1)(3)C)hexadecanoic acid; Pentadecanecarboxylic acid; 1-Pentadecanecarboxylate; Palmitic acid (natural); Hexadecanoic acid (9CI); Palmitic acid (7CI,8CI); Hexadecanoate (n-C16:0); Palmitic acid [USAN:NF]; Hexadecanoic acid anion; PALMITIC ACID [WHO-DD]; PALMITIC ACID [USP-RS]; pentadecanecarboxylate; Hexadecanoic--d5 Acid; PALMITIC ACID [VANDF]; PALMITIC ACID (MART.); PALMITIC ACID [MART.]; Palmitic acid, >=99\\%; PALMITIC ACID [USAN]; PALMITIC ACID [INCI]; 1-Hexyldecanoic Acid; PALMITIC ACID [HSDB]; Palmitic acid_RaGuSa; PALMITIC ACID [FHFI]; Palmitic acid, pure; n-Hexadecanoic acid; n-Hexadecyclic Acid; PALMITIC ACID [FCC]; PALMITIC ACID [DSC]; Palmitic acid_jeyam; PALMITIC ACID [MI]; Palmitate, Calcium; CETYL ACID [VANDF]; Palmitic acid 95\\%; Palmitic Acid, FCC; PALMITIC ACID [II]; Palmitic acid (NF); EDENOR C 16-98-100; Acid, Hexadecanoic; Hydrofol acid 1690; PALMITIC ACID (II); Hexadecanoic acid; n-Hexadecoic acid; Palmitate, Sodium; Calcium Palmitate; Sodium Palmitate; Hexadecanoicacid; CH3-(CH2)14-COOH; hexaectylic acid; 1-hexyldecanoate; CH3-[CH2]14-COOH; Hexadecylic acid; Palmitinic acid; Industrene 4516; UNII-2V16EO95H1; hexadecoic acid; fatty acid 16:0; N-Hexadecanoate; Pristerene 4934; Tox21_112105_1; palmitoic acid; C16 Fatty acid; Palmitinsaeure; Acid, Palmitic; palmitic-acid; Aethalic acid; Palmitinsaure; n-hexadecoate; Hystrene 8016; Hystrene 9016; Palmitic Acid; Kortacid 1698; Hexadecanoate; Loxiol ep 278; Tox21_201671; Lunac P 95KC; Cetylic acid; Hexaectylate; Tox21_302966; Tox21_112105; Hexadecylate; Prifrac 2960; Prifac 2960; Emersol 143; CAS-57-10-3; Univol u332; Hexadecoate; Emersol 140; palmic acid; Glycon P-45; Palmitinate; 2V16EO95H1; palmitoate; Lunac P 95; Cetyl acid; Edenor C16; Lunac P 98; WLN: QV15; palmitate; AI3-01594; Hydrofol; Cetylate; FA(16:0); FA 16:0; 16:00; C16:0; 2hmb; 3v2q; 2hnx; 1b56; FAT; PAM; C16; PLM; Palmitic acid; Hexadecanoic acid; n-Hexadecanoic acid



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(18)

BioCyc(0)

PlantCyc(0)

代谢反应

1213 个相关的代谢反应过程信息。

Reactome(343)

BioCyc(0)

WikiPathways(7)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(863)

PharmGKB(0)

2356 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 APOB, APOE, FABP4, FOXO1, PNPLA2, SIRT1
Peripheral membrane protein 2 LPL, PLIN2
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 4 APOB, DGAT1, PNPLA2, SPTSSA
Nucleus 7 APOE, CS, FABP4, FOXO1, PDX1, PLIN2, SIRT1
cytosol 11 ACACA, APOB, FABP4, FOXO1, GPT, LIPE, PDX1, PLIN2, PNPLA2, PRKCQ, SIRT1
dendrite 1 APOE
nucleoplasm 4 FOXO1, PDX1, PNPLA2, SIRT1
Cell membrane 4 GLP1R, LIPE, LPL, PNPLA2
Multi-pass membrane protein 5 DGAT1, GLP1R, PNPLA2, SPTSSA, UCP2
cell surface 1 LPL
glutamatergic synapse 1 APOE
Golgi apparatus 1 APOE
mitochondrial inner membrane 1 UCP2
neuronal cell body 2 APOB, APOE
smooth endoplasmic reticulum 1 APOB
Cytoplasm, cytosol 3 ACACA, LIPE, PDX1
plasma membrane 9 APOB, APOE, DGAT1, GCG, GLP1R, LPL, PLIN2, PNPLA2, PRKCQ
Membrane 7 APOE, CS, DGAT1, GLP1R, LIPE, PLIN2, PNPLA2
caveola 1 LIPE
extracellular exosome 5 APOB, APOE, CS, FABP4, GPT
endoplasmic reticulum 3 APOE, PLIN2, SPTSSA
extracellular space 5 APOB, APOE, CER1, GCG, LPL
lysosomal lumen 1 APOB
mitochondrion 6 ACACA, CS, FOXO1, PDX1, SIRT1, UCP2
intracellular membrane-bounded organelle 1 APOB
chromatin silencing complex 1 SIRT1
Secreted 5 APOB, APOE, CER1, GCG, LPL
extracellular region 6 APOB, APOE, CER1, GCG, LPL, PLIN2
Mitochondrion matrix 1 CS
mitochondrial matrix 2 CS, PDX1
Extracellular side 1 LPL
centriolar satellite 1 PRKCQ
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 2 APOE, LPL
chylomicron 3 APOB, APOE, LPL
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 2 APOB, APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 3 APOB, APOE, LPL
actin cytoskeleton 1 ACACA
nucleolus 1 SIRT1
Early endosome 2 APOB, APOE
Mitochondrion inner membrane 1 UCP2
heterochromatin 1 SIRT1
extracellular matrix 1 APOE
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
collagen-containing extracellular matrix 1 APOE
nuclear speck 1 PDX1
nuclear inner membrane 1 SIRT1
chromatin 3 FOXO1, PDX1, SIRT1
Secreted, extracellular space 1 APOE
blood microparticle 1 APOE
fibrillar center 2 ACACA, SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 APOB
Lipid droplet 5 APOB, FABP4, LIPE, PLIN2, PNPLA2
Membrane, caveola 1 LIPE
specific granule membrane 1 DGAT1
Melanosome 1 APOE
euchromatin 1 SIRT1
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 4 APOB, APOE, GCG, PNPLA2
pyruvate dehydrogenase complex 1 PDX1
endoplasmic reticulum exit site 1 APOB
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 2 APOB, APOE
synaptic cleft 1 APOE
serine palmitoyltransferase complex 1 SPTSSA
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 2 APOB, APOE
[Glucagon-like peptide 1]: Secreted 1 GCG
chylomicron remnant 2 APOB, APOE
intermediate-density lipoprotein particle 2 APOB, APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
mature chylomicron 1 APOB
catalytic complex 1 LPL
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Lisa Morisseau, Fumiya Tokito, Mathilde Lucas, Stéphane Poulain, Soo Hyeon Kim, Valérie Plaisance, Valérie Pawlowski, Cécile Legallais, Rachid Jellali, Yasuyuki Sakai, Amar Abderrahmani, Eric Leclerc. Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells. Gene. 2024 Jul; 917(?):148441. doi: 10.1016/j.gene.2024.148441. [PMID: 38608795]
  • Louyin Ji, Hui Han, Xiaoli Shan, Pei Zhao, Huihua Chen, Chen Zhang, Ming Xu, Rong Lu, Wei Guo. Ginsenoside Rb1 ameliorates lipotoxicity-induced myocardial injury in diabetes mellitus by regulating Mfn2. European journal of pharmacology. 2024 Jul; 974(?):176609. doi: 10.1016/j.ejphar.2024.176609. [PMID: 38677536]
  • Danyang Liu, Tao Wang, Xingqi Zhao, Juan Chen, Tianqi Yang, Yi Shen, Yu-Dong Zhou. Saturated fatty acids stimulate cytokine production in tanycytes via the PP2Ac-dependent signaling pathway. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2024 Jun; 44(6):985-999. doi: 10.1177/0271678x231219115. [PMID: 38069840]
  • Yunping Yao, Zhiyuan Qiang, Meng Zhang, Jia Lin, Changmo Li. Thermal oxidation mechanism of palmitic aicd. Food research international (Ottawa, Ont.). 2024 Jun; 186(?):114372. doi: 10.1016/j.foodres.2024.114372. [PMID: 38729730]
  • Lingming Chen, Shuai Liu, Yunting Zhang, Qiling Tang, Chunyu Quan, Jundan Wang, Xinsheng Peng, Xiaofang Zhong. Palmitic acid-capped MIL-101-Al as a nano-adjuvant to amplify immune responses against Pseudomonas aeruginosa. Nanoscale. 2024 May; 16(21):10306-10317. doi: 10.1039/d4nr01180e. [PMID: 38727538]
  • Swaraj Kumar Babu, Dibya Ranjan Sahoo, Prajna Parimita Mohanta, Pradeep Kumar Naik. Exploring the antifilarial potential of an important medicinal plant Typhonium trilobatum (L. Schoot): Isolation, characterization, and structural elucidation of bioactive compounds against Brugia malayi. Journal of ethnopharmacology. 2024 May; 326(?):117858. doi: 10.1016/j.jep.2024.117858. [PMID: 38346526]
  • Ziyi Zhao, Jiandong Wang, Weimin Kong, Meredith A Newton, Wesley C Burkett, Wenchuan Sun, Lindsey Buckingham, Jillian O'Donnell, Hongyan Suo, Boer Deng, Xiaochang Shen, Xin Zhang, Tianran Hao, Chunxiao Zhou, Victoria L Bae-Jump. Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer. Biomolecules. 2024 May; 14(5):. doi: 10.3390/biom14050601. [PMID: 38786008]
  • Chenyang Jin, Shuangjie Wang, Xiangyu Sui, Qingyang Meng, Guohao Wu. Low expression of ELOVL6 may be involved in fat loss in white adipose tissue of cancer-associated cachexia. Lipids in health and disease. 2024 May; 23(1):144. doi: 10.1186/s12944-024-02126-9. [PMID: 38760797]
  • Yoshihiro Shidoji. Induction of Hepatoma Cell Pyroptosis by Endogenous Lipid Geranylgeranoic Acid-A Comparison with Palmitic Acid and Retinoic Acid. Cells. 2024 May; 13(10):. doi: 10.3390/cells13100809. [PMID: 38786033]
  • Xi Chen, Kun Chen, Jun Hu, Yijun Dong, Menglong Zheng, Jiang Jiang, Qingsong Hu, Wenzhi Zhang. Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway. Communications biology. 2024 May; 7(1):539. doi: 10.1038/s42003-024-06248-9. [PMID: 38714886]
  • Sajad Malik, Shrirang Inamdar, Jhankar Acharya, Pranay Goel, Saroj Ghaskadbi. Characterization of palmitic acid toxicity induced insulin resistance in HepG2 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2024 May; 97(?):105802. doi: 10.1016/j.tiv.2024.105802. [PMID: 38431059]
  • Huiquan Zhu, Pu Zhao, Xiaodan Wang, Yunna Wang, Shuwen Zhang, Xiaoyang Pang, Jiaping Lv. Fabrication of Human Milk Fat Substitute: Based on the Similarity Evaluation Model and Computer Software. Molecules (Basel, Switzerland). 2024 May; 29(9):. doi: 10.3390/molecules29092096. [PMID: 38731587]
  • Man-Ru Zhang, Bang-Yun Zuo, Yu-Chen Song, Dan-Dan Guo, Qing-Liu Li, Jin-Xiu Lyu, Hua Zhu, Jing Zhao, Peng-Zhou Hang. BDNF mimetics recover palmitic acid-induced injury in cardiomyocytes by ameliorating Akt-dependent mitochondrial impairments. Toxicology and applied pharmacology. 2024 May; 486(?):116951. doi: 10.1016/j.taap.2024.116951. [PMID: 38705401]
  • Dongxiao Liu, Ruth Cruz-Cosme, Yong Wu, Julian Leibowitz, Qiyi Tang. 2-Bromopalmitate depletes lipid droplets to inhibit viral replication. Journal of virology. 2024 Apr; 98(4):e0017124. doi: 10.1128/jvi.00171-24. [PMID: 38488361]
  • Ruimin Tian, Xianfeng Liu, Yang Xiao, Lijia Jing, Honglin Tao, Lu Yang, Xianli Meng. Huang-Lian-Jie-Du decoction drug-containing serum inhibits IL-1β secretion from D-glucose and PA induced BV2 cells via autophagy/NLRP3 signaling. Journal of ethnopharmacology. 2024 Apr; 323(?):117686. doi: 10.1016/j.jep.2023.117686. [PMID: 38160864]
  • Jinhui Dong, Xiaohui Tong, Jing Xu, Min Pan, Lei Wang, Fei Xu, Yajuan Wang, Li Li, Tongsheng Wang. Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice. European journal of pharmacology. 2024 Apr; 968(?):176388. doi: 10.1016/j.ejphar.2024.176388. [PMID: 38367685]
  • Maria Sofia Molonia, Federica Lina Salamone, Antonio Speciale, Antonella Saija, Francesco Cimino. D-Allulose Reduces Hypertrophy and Endoplasmic Reticulum Stress Induced by Palmitic Acid in Murine 3T3-L1 Adipocytes. International journal of molecular sciences. 2024 Apr; 25(7):. doi: 10.3390/ijms25074059. [PMID: 38612868]
  • Chaofeng Wu, Junjie Li, Hui Jia, Jiamin Zhao, Mengchen Qin, Hao Shi, Chang Liu, Jiajie Lin, Min Cai, Yong Gu, Bin Liu, Lei Gao. Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis. Journal of gastroenterology. 2024 04; 59(4):342-356. doi: 10.1007/s00535-024-02082-2. [PMID: 38402297]
  • Yu-Feng Song, Ling-Jiao Wang, Zhi Luo, Christer Hogstrand, Xiao-Hong Lai, Fei-Fei Zheng. Moderate replacement of fish oil with palmitic acid-stimulated mitochondrial fusion promotes β-oxidation by Mfn2 interacting with Cpt1α via its GTPase-domain. The Journal of nutritional biochemistry. 2024 Apr; 126(?):109559. doi: 10.1016/j.jnutbio.2023.109559. [PMID: 38158094]
  • Wuxian Zhong, Ai Zhao, Xuetao Wei, Shuai Mao, Pin Li, Qianqian Shen, Hong Zhang, Hua Jiang, Peiyu Wang, Yumei Zhang. The Effect of Sn-2 Palmitate on Blood Glucose, Lipids and Body Composition in Middle-Aged and Elderly Adults: A Randomized, Double-Blinded Controlled Trial. Nutrients. 2024 Mar; 16(7):. doi: 10.3390/nu16070973. [PMID: 38613008]
  • Yan Yang, Wen Qiu, Jiyuan Xiao, Jie Sun, Xuan Ren, Luxia Jiang. Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway. Journal of translational medicine. 2024 Mar; 22(1):309. doi: 10.1186/s12967-024-05060-7. [PMID: 38532480]
  • Juan Li, Zhengcai Ma, Zhipeng Yang, Maochun Yang, Changsheng Li, Mengmeng Li, Xiaoduo Li, Xiantao Chen, Hang Ma, Wanqun Chen, Xiaoli Ye, Xuegang Li. Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis. Journal of ethnopharmacology. 2024 Mar; 322(?):117600. doi: 10.1016/j.jep.2023.117600. [PMID: 38103844]
  • Eugene Chang. Vitamin D Mitigates Hepatic Fat Accumulation and Inflammation and Increases SIRT1/AMPK Expression in AML-12 Hepatocytes. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061401. [PMID: 38543036]
  • Ting Hu, Wen Zhang, Feifei Han, Rui Zhao, Hongchuan Liu, Zhuoling An. Machine learning reveals serum myristic acid, palmitic acid and heptanoylcarnitine as biomarkers of coronary artery disease risk in patients with type 2 diabetes mellitus. Clinica chimica acta; international journal of clinical chemistry. 2024 Mar; 556(?):117852. doi: 10.1016/j.cca.2024.117852. [PMID: 38438006]
  • Peipei Han, Chunhua Yuan, Xiaoyu Chen, Yuanqing Hu, Xiaodan Hu, Zhangtao Xu, Qi Guo. Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC-MS and LC-MS. Skeletal muscle. 2024 Mar; 14(1):4. doi: 10.1186/s13395-024-00337-3. [PMID: 38454497]
  • Hang Pan, Longfeng Wei, Hao Zhao, Yang Xiao, Zhu Li, Haixia Ding. Perception of the Biocontrol Potential and Palmitic Acid Biosynthesis Pathway of Bacillus subtilis H2 through Merging Genome Mining with Chemical Analysis. Journal of agricultural and food chemistry. 2024 Mar; 72(9):4834-4848. doi: 10.1021/acs.jafc.3c06411. [PMID: 38401001]
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