Ferulic acid (BioDeep_00000000309)

 

Secondary id: BioDeep_00000265017, BioDeep_00000400088, BioDeep_00000400145, BioDeep_00000400184

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid

化学式: C10H10O4 (194.0579)
中文名称: 阿魏酸
谱图信息: 最多检出来源 Homo sapiens(feces) 30.29%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

Ferulic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ferulic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000309). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(c(ccc(c1)/C=C/C(=O)O)O)OC
InChI: InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)

描述信息

trans-Ferulic acid is a highly abundant phenolic phytochemical which is present in plant cell walls. Ferulic acid is a phenolic acid that can be absorbed by the small intestine and excreted through the urine. It is one of the most abundant phenolic acids in plants, varying from 5 g/kg in wheat bran to 9 g/kg in sugar-beet pulp and 50 g/kg in corn kernel. It occurs primarily in seeds and leaves both in its free form (albeit rarely) and covalently linked to lignin and other biopolymers. It is usually found as ester cross-links with polysaccharides in the cell wall, such as arabinoxylans in grasses, pectin in spinach and sugar beet, and xyloglucans in bamboo. It also can cross-link with proteins. Due to its phenolic nucleus and an extended side chain conjugation (carbohydrates and proteins), it readily forms a resonance-stabilized phenoxy radical which accounts for its potent antioxidant potential. Food supplementation with curcumin and ferulic acid is considered a nutritional approach to reducing oxidative damage and amyloid pathology in Alzheimer disease (PMID:17127365, 1398220, 15453708, 9878519). Ferulic acid can be found in Pseudomonas and Saccharomyces (PMID:8395165).
Ferulic acid is a ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring. It has a role as an antioxidant, a MALDI matrix material, a plant metabolite, an anti-inflammatory agent, an apoptosis inhibitor and a cardioprotective agent. It is a conjugate acid of a ferulate.
Ferulic acid is a natural product found in Haplophyllum griffithianum, Visnea mocanera, and other organisms with data available.
Ferulic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
See also: Angelica sinensis root (part of).
Widely distributed in plants, first isolated from Ferula foetida (asafoetida). Antioxidant used to inhibit oxidn. of fats, pastry products, etc. Antifungal agent used to prevent fruit spoilage. trans-Ferulic acid is found in many foods, some of which are deerberry, peach, shea tree, and common bean.
A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000975 - Antioxidants > D016166 - Free Radical Scavengers
D006401 - Hematologic Agents > D000925 - Anticoagulants
D020011 - Protective Agents > D000975 - Antioxidants
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID H074
(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

同义名列表

95 个代谢物同义名

Ferulic Acid, Pharmaceutical Secondary Standard; Certified Reference Material; InChI=1/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13; trans-Ferulic acid, matrix substance for MALDI-MS, >=99.0\\% (HPLC); Ferulic acid, United States Pharmacopeia (USP) Reference Standard; trans-Ferulic acid, certified reference material, TraceCERT(R); Diethyl2-(acetamido)-2-(2-(bromomethyl)-5-nitrobenzyl)malonate; Ferulic acid, European Pharmacopoeia (EP) Reference Standard; 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (2E)-; 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (E)-; (E)-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enoic acid; (2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid; (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid; (E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid; (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid; (E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid; (2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-acrylic acid; (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoicacid; 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-; FERULIC ACID (CONSTITUENT OF BLACK COHOSH) [DSC]; Trans-3-(4-hydroxy-3-methoxyphenyl)acrylic acid; (2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoate; CINNAMIC ACID,4-HYDROXY,3-METHOXY FERULIC ACID; (2E)-3-(4-Hydroxy-3-methoxyphenyl)acrylic acid; 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid; 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid; (E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoate; (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid; trans-Ferulic Acid (purified by sublimation); Cinnamic acid, 4-hydroxy-3-methoxy-, trans-; 3-(4-Hydroxy-3-methoxyphenyl)propenoic acid; FERULIC ACID (CONSTITUENT OF BLACK COHOSH); Cinnamic acid, 4-hydroxy-3-methoxy-, (E)-; 3-(4-Hydroxy-3-methoxyphenyl)acrylic acid; 3-methoxy-4-hydroxy-trans-cinnamic acid; 4-Hydroxy-3-methoxycinnamic acid, trans; 3-(4-Hydroxy-3-methoxyphenyl)propenoate; trans-3-methoxy-4-hydroxycinnamic acid; trans-4-Hydroxy-3-methoxycinnamic acid; (E)-4-hydroxy-3-methoxy-Cinnamic acid; trans-4-Hydroxy-3-methoxycinnamicacid; 4-HYDROXY-3-METHOXY-D3-CINNAMIC ACID; (E)-4-Hydroxy-3-methoxycinnamic acid; Cinnamic acid, 4-hydroxy-3-methoxy-; (E)4-hydroxy-3-methoxycinnamic acid; 3-Methoxy-4-hydroxy-trans-cinnamate; trans-4-Hydroxy-3-methoxycinnamate; 4’-Hydroxy-3’-methoxycinnamic acid; (E)-4-hydroxy-3-methoxy-Cinnamate; 4-Hydroxy-3-methoxy cinnamic acid; (e)-4-Hydroxy-3-methoxycinnamate; (E)-4-Hydroxy-3-methoxycinnamate; 4-Hydroxy-3-methoxycinnamic acid; 3-methoxy-4-hydroxycinnamic acid; 4-hydroxy-3-methoxycinnamic acid; ferulic acid, monosodium salt; 4-Hydroxy-3-methoxycinnamate; TRANS-FERULIC ACID [WHO-DD]; caffeic acid 3-methyl ether; Fumalic acid (Ferulic acid); trans-Ferulic acid, >=99\\%; trans-Ferulic acid, 99\\%; ferulic acid, (E)-isomer; ferulic acid, (Z)-isomer; FERULIC ACID [USP-RS]; FERULIC ACID (USP-RS); FERULIC ACID [WHO-DD]; Ferulic acid, trans-; FERULIC ACID [HSDB]; FERULIC ACID [INCI]; (E)-Coniferic acid; 8,8-diferulic acid; trans-ferulic acid; Ferulic acid (M5); trans-FerulicAcid; FERULIC ACID [MI]; Ferulic Acid ,(S); Spectrum5_000554; (E)-Ferulic acid; Ferulic acid, E-; cis-ferulic acid; CIS-FERULICACID; sodium ferulate; Coniferic acid; trans-Ferulate; Ferulaic acid; Ferulic acid; (E)-Ferulate; Fumalic acid; FERULIC-ACID; Ferulicacid; ferulasaure; ferulate; Ferulic; trans-Ferulic acid; Ferulate



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

226 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(225)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2260 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, ANXA5, BCL2, CTNNB1, HPGDS, MAPK1, NOS3, PTGS2, RELA, SIRT1, STAT3, TP53, TYR, VEGFA
Peripheral membrane protein 2 ANXA5, PTGS2
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 10 BCL2, CTNNB1, HMOX1, MAPK1, NOS3, RELA, SIRT1, STAT3, TP53, VEGFA
cytosol 13 ANXA5, BCL2, CTNNB1, GSR, HMOX1, HPGDS, IL1B, MAPK1, NOS3, RELA, SIRT1, STAT3, TP53
centrosome 3 CTNNB1, MAPK1, TP53
nucleoplasm 9 CTNNB1, HMOX1, HPGDS, MAPK1, NOS3, RELA, SIRT1, STAT3, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 2 ABCB1, CTNNB1
Cytoplasmic side 1 HMOX1
lamellipodium 1 CTNNB1
Multi-pass membrane protein 1 ABCB1
Synapse 2 CTNNB1, MAPK1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 2 ABCB1, VEGFA
glutamatergic synapse 2 CTNNB1, RELA
Golgi apparatus 3 MAPK1, NOS3, VEGFA
Golgi membrane 1 NOS3
presynaptic membrane 1 CTNNB1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 IL1B
Lysosome 2 IL1B, TYR
plasma membrane 6 ABCB1, BCHE, CTNNB1, MAPK1, NOS3, STAT3
Membrane 7 ABCB1, ANXA5, BCL2, CTNNB1, HMOX1, TP53, VEGFA
apical plasma membrane 1 ABCB1
basolateral plasma membrane 1 CTNNB1
caveola 3 MAPK1, NOS3, PTGS2
extracellular exosome 4 ABCB1, ANXA5, CTNNB1, GSR
endoplasmic reticulum 5 BCL2, HMOX1, PTGS2, TP53, VEGFA
extracellular space 6 BCHE, CCL2, CXCL8, HMOX1, IL1B, VEGFA
perinuclear region of cytoplasm 4 CTNNB1, HMOX1, NOS3, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 5 BCL2, GSR, MAPK1, SIRT1, TP53
protein-containing complex 4 BCL2, CTNNB1, PTGS2, TP53
intracellular membrane-bounded organelle 2 HPGDS, TYR
Microsome membrane 1 PTGS2
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 TYR
Secreted 5 BCHE, CCL2, CXCL8, IL1B, VEGFA
extracellular region 7 ANXA5, BCHE, CCL2, CXCL8, IL1B, MAPK1, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 GSR, TP53
transcription regulator complex 4 CTNNB1, RELA, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 MAPK1, TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, GSR
Secreted, extracellular space, extracellular matrix 1 VEGFA
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 2 SIRT1, TP53
Wnt signalosome 1 CTNNB1
Melanosome membrane 1 TYR
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 MAPK1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
Golgi-associated vesicle 1 TYR
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
heterochromatin 1 SIRT1
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 3 ANXA5, CTNNB1, MAPK1
spindle 1 MAPK1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 VEGFA
Nucleus, PML body 2 SIRT1, TP53
PML body 2 SIRT1, TP53
collagen-containing extracellular matrix 1 ANXA5
secretory granule 2 IL1B, VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK1
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 4 RELA, SIRT1, STAT3, TP53
cell periphery 1 CTNNB1
mitotic spindle 1 MAPK1
cytoskeleton 2 MAPK1, NOS3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
blood microparticle 1 BCHE
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
Endomembrane system 1 CTNNB1
Membrane, caveola 1 MAPK1
Melanosome 1 TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 2 CTNNB1, SIRT1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
pseudopodium 1 MAPK1
ficolin-1-rich granule lumen 1 MAPK1
endoplasmic reticulum lumen 3 BCHE, MAPK1, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
endocytic vesicle membrane 1 NOS3
beta-catenin-TCF complex 1 CTNNB1
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 1 MAPK1
Single-pass type IV membrane protein 1 HMOX1
nuclear envelope lumen 1 BCHE
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 CTNNB1
external side of apical plasma membrane 1 ABCB1
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
catenin complex 1 CTNNB1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Peng Shu, Jiaxin Mo, Zunjiang Li, Mingjie Li, Wei Zhu, Zhiyun Du. Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging. Aging. 2024 Apr; 16(8):7153-7173. doi: 10.18632/aging.205749. [PMID: 38643459]
  • Sapna I, A Jayadeep. Enzyme-treated red rice (Oryza sativa L.) bran extracts mitigate inflammatory markers in RAW 264.7 macrophage cells and exhibit anti-inflammatory efficacy greater/comparable to ferulic acid, catechin, γ-tocopherol, and γ-oryzanol. Journal of ethnopharmacology. 2024 Apr; 323(?):117616. doi: 10.1016/j.jep.2023.117616. [PMID: 38142877]
  • Akihiro Shirai, Ami Tanaka. Effects of ferulic acid combined with light irradiation on deoxynivalenol and its production in Fusarium graminearum. Fungal biology. 2024 04; 128(2):1684-1690. doi: 10.1016/j.funbio.2024.02.003. [PMID: 38575241]
  • Xiaochong Zhu, Jieyuan Wu, Shizhong Li, La Xiang, Jian-Ming Jin, Chaoning Liang, Shuang-Yan Tang. Artificial Biosynthetic Pathway for Efficient Synthesis of Vanillin, a Feruloyl-CoA-Derived Natural Product from Eugenol. Journal of agricultural and food chemistry. 2024 Mar; 72(12):6463-6470. doi: 10.1021/acs.jafc.3c08723. [PMID: 38501643]
  • Jasmin Bayer, Petra Högger. Development and validation of a LC-MS/MS method for the quantification of phenolic compounds in human saliva after intake of a procyanidin-rich pine bark extract. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115914. doi: 10.1016/j.jpba.2023.115914. [PMID: 38101241]
  • Rania A Gawish, Esraa M Samy, Maha M Aziz. Ferulic acid protects against gamma-radiation induced liver injury via regulating JAK/STAT/Nrf2 pathways. Archives of biochemistry and biophysics. 2024 Jan; 753(?):109895. doi: 10.1016/j.abb.2024.109895. [PMID: 38244663]
  • Tomasz Kowalczyk, Joanna Sikora, Anna Merecz-Sadowska, Wirginia Kukula-Koch, Ewelina Synowiec, Agata Majda, Dawid Juda, Tomasz Śliwiński, Przemysław Sitarek. Biological Properties of Extracts Obtained from In Vitro Culture of Plectranthus scutellarioides in a Cell Model. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25021043. [PMID: 38256118]
  • Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu. Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgad127. [PMID: 38215001]
  • Zhihao Sun, Wenqiao An, Taiping He, Qingqing Liu, Ziming Wang, Pengmei Guo, Sanyin Zhang. Real-Time Detection of Ferulic Acid Effects on Rat Left Ventricle Using Pressure-Volume Conductivity Catheter. Journal of visualized experiments : JoVE. 2024 Jan; ?(203):. doi: 10.3791/65858. [PMID: 38284554]
  • Guanghui Li, Junle Li, Yee-Ying Lee, Chaoying Qiu, Xiaofang Zeng, Yong Wang. Pickering emulsions stabilized by chitosan-flaxseed gum-hyaluronic acid nanoparticles for controlled topical release of ferulic acid. International journal of biological macromolecules. 2024 Jan; 255(?):128086. doi: 10.1016/j.ijbiomac.2023.128086. [PMID: 37981278]
  • Huahua Li, Ziwei Peng, Yang Song, Minhang Dou, Xinying Lu, Minghui Li, Xiaofeng Zhai, Yan Gu, Rexidanmu Mamujiang, Shouying Du, Jie Bai. Study of the permeation-promoting effect and mechanism of solid microneedles on different properties of drugs. Drug delivery. 2023 Dec; 30(1):2165737. doi: 10.1080/10717544.2023.2165737. [PMID: 36644816]
  • Asif Hameed, Duc Hai Nguyen, Shih-Yao Lin, Paul Stothard, Poovarasan Neelakandan, Li-Sen Young, Chiu-Chung Young. Hormesis of glyphosate on ferulic acid metabolism and antifungal volatile production in rice root biocontrol endophyte Burkholderia cepacia LS-044. Chemosphere. 2023 Dec; 345(?):140511. doi: 10.1016/j.chemosphere.2023.140511. [PMID: 37871874]
  • Gulay Ozkan. Valorization of artichoke outer petals by using ultrasound-assisted extraction and natural deep eutectic solvents (NADES) for the recovery of phenolic compounds. Journal of the science of food and agriculture. 2023 Nov; ?(?):. doi: 10.1002/jsfa.13158. [PMID: 37989526]
  • Saarika Pothuvan Kunnummal, Nidhi Sori, Mudassir Azeez Khan, Mahejibin Khan. Plant-Based Nutraceutical Formulation Modulates the Human Gut Microbiota and Ferulic Acid Esterase Activity During In Vitro Fermentation. Current microbiology. 2023 Nov; 81(1):3. doi: 10.1007/s00284-023-03518-3. [PMID: 37940729]
  • Guanglu Wang, Jiajia Guo, Yeyun Ma, Yue Xin, Xiaomeng Ji, Ying Sun, Jian Zhang, Jingquan Dong. Ferulic acid alleviates carp brain damage and growth inhibition caused by avermectin by modulating the Nrf2/Keap1 and NF-κB signaling pathways. Pesticide biochemistry and physiology. 2023 Nov; 196(?):105590. doi: 10.1016/j.pestbp.2023.105590. [PMID: 37945241]
  • Yong Cheng, Xi Chen, Tian Yang, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Fang Qin, Jie Chen, Zhiyong He. Effects of whey protein isolate and ferulic acid/phloridzin/naringin/cysteine on the thermal stability of mulberry anthocyanin extract at neutral pH. Food chemistry. 2023 Nov; 425(?):136494. doi: 10.1016/j.foodchem.2023.136494. [PMID: 37270886]
  • Fang Ma, Yuan Jiang, Baoshan Li, Yuxin Zeng, Hushan Shang, Fusheng Wang, Zhirong Sun. The Dynamic Accumulation Rules of Chemical Components during the Medicine Formation Period of Angelica sinensis and Chemometric Classifying Analysis for Different Bolting Times Using ATR-FTIR. Molecules (Basel, Switzerland). 2023 Oct; 28(21):. doi: 10.3390/molecules28217292. [PMID: 37959713]
  • Meryem Tourabi, Amira Metouekel, Asmae E L Ghouizi, Mohamed Jeddi, Ghizlane Nouioura, Hassan Laaroussi, Md Eram Hosen, Kawtar Fikri Benbrahim, Mohammed Bourhia, Ahmad Mohammad Salamatullah, Hiba-Allah Nafidi, Gezahign Fentahun Wondmie, Badiaa Lyoussi, Elhoussine Derwich. Efficacy of various extracting solvents on phytochemical composition, and biological properties of Mentha longifolia L. leaf extracts. Scientific reports. 2023 10; 13(1):18028. doi: 10.1038/s41598-023-45030-5. [PMID: 37865706]
  • Guojun Zhang, Linqin Meng, Rui Chen, Wen Wang, Xiangfeng Jing, Keyan Zhu-Salzman, Weining Cheng. Characterization of three glutathione S-transferases potentially associated with adaptation of the wheat blossom midge Sitodiplosis mosellana to host plant defense. Pest management science. 2023 Oct; ?(?):. doi: 10.1002/ps.7824. [PMID: 37814473]
  • Yu Wang, Jia-Jia Qi, Yi-Jing Yin, Hao Jiang, Jia-Bao Zhang, Shuang Liang, Bao Yuan. Ferulic Acid Enhances Oocyte Maturation and the Subsequent Development of Bovine Oocytes. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914804. [PMID: 37834252]
  • Manas Kinra, Niraja Ranadive, Madhavan Nampoothiri, Devinder Arora, Jayesh Mudgal. Involvement of NLRP3 inflammasome pathway in the protective mechanisms of ferulic acid and p-coumaric acid in LPS-induced sickness behavior and neuroinflammation in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Sep; ?(?):. doi: 10.1007/s00210-023-02743-8. [PMID: 37755515]
  • Longkun Liu, Yoann Birling, Yan Zhao, Wenxin Ma, Yang Tang, Yuxin Sun, Xuehui Wang, Mingkun Yu, Hongsheng Bi, Jian-Ping Liu, Li Li, Zhaolan Liu. Mechanism of Chinese botanical drug Dizhi pill for myopia: An integrated study based on bioinformatics and network analysis. Medicine. 2023 Sep; 102(38):e34753. doi: 10.1097/md.0000000000034753. [PMID: 37747014]
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  • Ali Salimi, Mohsen Eslami, Farhad Farrokhi-Ardabili. Influence of trans-ferulic acid on the quality of ram semen upon cold preservation. Veterinary medicine and science. 2023 Mar; ?(?):. doi: 10.1002/vms3.1117. [PMID: 36913307]
  • Mohamad Fawzi Mahomoodally, Gokhan Zengin, Seebaluck-Sandoram Roumita, Giovanni Caprioli, Ahmed M Mustafa, Diletta Piatti, Evren Yıldıztugay, Gunes Ak, Ayşe Esra Karadağ, Asaad Khalid, Ashraf N Abdalla, Abdullahi Ibrahim Uba, Fatih Demirci. Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches. Chemistry & biodiversity. 2023 Mar; ?(?):e202201181. doi: 10.1002/cbdv.202201181. [PMID: 36891864]
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  • Zhengrong Mei, Hong Ye, Haiyi Yang, Shihong Cai, Yujun Hu, Qibo Chen, Zhongwen Yuan, Xixia Liu. Ferulic acid alleviates high fat diet-induced cognitive impairment by inhibiting oxidative stress and apoptosis. European journal of pharmacology. 2023 Mar; ?(?):175642. doi: 10.1016/j.ejphar.2023.175642. [PMID: 36871664]
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  • Yumin Cao, Ning Zhou, Tong Liu, Jinying Zhang, Yongxiang Wang, Bingxian Zhang, Zhenkai Zhang, Weisheng Feng, Xiaoke Zheng. Comparative pharmacokinetic studies of Ephedra herba in common cold and nephrotic syndrome rat models. Journal of separation science. 2023 Feb; ?(?):e2200895. doi: 10.1002/jssc.202200895. [PMID: 36823773]
  • Pei-Lin Li, Xiao-Xue Zhai, Jun Wang, Xiang Zhu, Lin Zhao, Shuang You, Chun-Yan Sang, Jun-Li Yang. Two Ferulic Acid Derivatives Inhibit Neuroinflammatory Response in Human HMC3 Microglial Cells via NF-κB Signaling Pathway. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052080. [PMID: 36903325]
  • Wenwen Tang, Yuan Chen, Fengxia Guo. Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041942. [PMID: 36838931]
  • Dario Lučić, Iva Pavlović, Lidija Brkljačić, Sandro Bogdanović, Vladimir Farkaš, Andrea Cedilak, Lucia Nanić, Ivica Rubelj, Branka Salopek-Sondi. Antioxidant and Antiproliferative Activities of Kale (Brassica oleracea L. Var. acephala DC.) and Wild Cabbage (Brassica incana Ten.) Polyphenolic Extracts. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041840. [PMID: 36838827]
  • Laura Hautrive Milanesi, Domenika Rubert Rossato, Jéssica Leandra Oliveira Rosa, Lívia Ferraz D'avila, Vinícia Garzella Metz, Camila Reck Rampelotto, Viviane Gonçalves Pereira, Scheila Rezende Schaffazick, Cristiane de Bona da Silva, Marilise E Burger. Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ΔFosB in the striatum brain area of rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Feb; ?(?):. doi: 10.1007/s00210-023-02420-w. [PMID: 36790483]
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  • Nanhai Zhang, Jingxuan Zhou, Liang Zhao, Zhen Zhao, Shiran Wang, Liebing Zhang, Feng Zhou. Ferulic acid supplementation alleviates hyperuricemia in high-fructose/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota. Food & function. 2023 Feb; 14(3):1710-1725. doi: 10.1039/d2fo03332a. [PMID: 36722874]
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  • Junying Ma, Xiaoyan Li, Maolin He, Yanwen Li, Wei Lu, Mengyao Li, Bo Sun, Yangxia Zheng. A Joint Transcriptomic and Metabolomic Analysis Reveals the Regulation of Shading on Lignin Biosynthesis in Asparagus. International journal of molecular sciences. 2023 Jan; 24(2):. doi: 10.3390/ijms24021539. [PMID: 36675053]
  • Shujie Ma, Ran Jia, Xin Li, Wen Wang, Liyu Jin, Xinxin Zhang, Hualong Yu, Juan Yang, Lili Dong, Lihui Zhang, Jingao Dong. Herbicidal Active Compound Ferulic Acid Ethyl Ester Affects Fatty Acid Synthesis by Targeting the 3-Ketoacyl-Acyl Carrier Protein Synthase I (KAS I). Journal of agricultural and food chemistry. 2023 Jan; 71(1):276-287. doi: 10.1021/acs.jafc.2c07214. [PMID: 36588523]
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  • Agnieszka Szewczyk, Wojciech Paździora, Halina Ekiert. The Influence of Exogenous Phenylalanine on the Accumulation of Secondary Metabolites in Agitated Shoot Cultures of Ruta graveolens L. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020727. [PMID: 36677781]
  • Mingying Liu, Ju Mu, Wan Gong, Kena Zhang, Maoyun Yuan, Yizhi Song, Bei Li, Naifu Jin, Wenjing Zhang, Dayi Zhang. In Vitro Diagnosis and Visualization of Cerebral Ischemia/Reperfusion Injury in Rats and Protective Effects of Ferulic Acid by Raman Biospectroscopy and Machine Learning. ACS chemical neuroscience. 2023 01; 14(1):159-169. doi: 10.1021/acschemneuro.2c00612. [PMID: 36516359]
  • Di Zhang, Bei Jing, Zhen-Ni Chen, Xin Li, Hui-Mei Shi, Ya-Chun Zheng, Shi-Quan Chang, Li Gao, Guo-Ping Zhao. Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4/NF-κB pathway. CNS neuroscience & therapeutics. 2023 Jan; ?(?):. doi: 10.1111/cns.14060. [PMID: 36601662]
  • Siyu Zhou, Xiaoyu Dong. Neuroprotective Properties of Ferulic Acid in Preclinical Models of Alzheimer's Disease: A Systematic Literature Review. Current medicinal chemistry. 2023; 30(24):2796-2811. doi: 10.2174/0929867329666220906110506. [PMID: 36065925]
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  • Mohd Suhail, Mohammad Tarique, Shams Tabrez, Torki A Zughaibi, Mohd Rehan. Synergistic inhibition of glioblastoma multiforme through an in-silico analysis of luteolin and ferulic acid derived from Angelica sinensis and Cannabis sativa: Advancements in computational therapeutics. PloS one. 2023; 18(11):e0293666. doi: 10.1371/journal.pone.0293666. [PMID: 37943817]
  • Mayy M Mostafa, Mohamed A Farag. Profiling of primary and phytonutrients in edible mahlab cherry (Prunus mahaleb L.) seeds in the context of its different cultivars and roasting as analyzed using molecular networking and chemometric tools. PeerJ. 2023; 11(?):e15908. doi: 10.7717/peerj.15908. [PMID: 37663279]
  • Ya-Nan Su, Mei-Jiao Wang, Jun-Pu Yang, Xiang-Lu Wu, Min Xia, Mei-Hua Bao, Yu-Bin Ding, Qian Feng, Li-Juan Fu. Effects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome. Frontiers in endocrinology. 2023; 14(?):1122709. doi: 10.3389/fendo.2023.1122709. [PMID: 36814581]
  • Yingkun Liu, Tao Zhang, Fangyuan Jia, Haojia Li, Meng Sun, Zengyu Fu, Haizhu Zhou, Wei Guo, Yunhang Gao. Effects of ferulic acid on growth performance and intestinal oxidation indexes of Jilin white geese under lipopolysaccharide-induced oxidative stress. PloS one. 2023; 18(10):e0291955. doi: 10.1371/journal.pone.0291955. [PMID: 37824519]
  • Ping Huang, Xing Chen, Rong-Hua Meng, Jun Lu, Yan Zhang, Li Li, Yong-Wen Li. [Methyl ferulic acid ameliorates ethanol-induced L02 cell steatosis through microRNA-378b-mediated CaMKK2-AMPK pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jan; 48(1):193-201. doi: 10.19540/j.cnki.cjcmm.20220905.702. [PMID: 36725271]
  • Islam M Khattab, Jochen Fischer, Andrzej Kaźmierczak, Eckhard Thines, Peter Nick. Ferulic acid is a putative surrender signal to stimulate programmed cell death in grapevines after infection with Neofusicoccum parvum. Plant, cell & environment. 2023 01; 46(1):339-358. doi: 10.1111/pce.14468. [PMID: 36263963]
  • Lei Ye, Pan Hu, Li-Ping Feng, Li-Lu Huang, Yi Wang, Xin Yan, Jing Xiong, Hou-Lin Xia. Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review. Molecules (Basel, Switzerland). 2022 Dec; 28(1):. doi: 10.3390/molecules28010281. [PMID: 36615475]
  • Veronica F Salau, Ochuko L Erukainure, Kolawole O Olofinsan, Vishal Bharuth, Omamuyovwi M Ijomone, Md Shahidul Islam. Ferulic acid improves glucose homeostasis by modulation of key diabetogenic activities and restoration of pancreatic architecture in diabetic rats. Fundamental & clinical pharmacology. 2022 Dec; ?(?):. doi: 10.1111/fcp.12860. [PMID: 36541946]
  • Qian Zhang, Meixuan Li, Guiyan Yang, Xiaoqiang Liu, Zhongdong Yu, Shaobing Peng. Protocatechuic acid, ferulic acid and relevant defense enzymes correlate closely with walnut resistance to Xanthomonas arboricola pv. juglandis. BMC plant biology. 2022 Dec; 22(1):598. doi: 10.1186/s12870-022-03997-9. [PMID: 36539704]
  • Tugba Kose, Paul A Sharp, Gladys O Latunde-Dada. Upregulation of Nrf2 Signalling and the Inhibition of Erastin-Induced Ferroptosis by Ferulic Acid in MIN6 Cells. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232415886. [PMID: 36555529]
  • Xin-Yu Lin, Jing Zhou, Cai-Feng Hao, He Zhu, Shan-Shan Zhou, Jin-Di Xu, Qian Mao, Song-Lin Li, Ming Kong. Quality consistency evaluation of commercial Prunellae Spica by integrating determination of secondary metabolites and saccharides. Phytochemical analysis : PCA. 2022 Dec; ?(?):. doi: 10.1002/pca.3197. [PMID: 36494085]
  • Kaili Cui, Lichao Zhang, Xiaoqin La, Haili Wu, Ruipeng Yang, Hanqing Li, Zhuoyu Li. Ferulic Acid and P-Coumaric Acid Synergistically Attenuate Non-Alcoholic Fatty Liver Disease through HDAC1/PPARG-Mediated Free Fatty Acid Uptake. International journal of molecular sciences. 2022 Dec; 23(23):. doi: 10.3390/ijms232315297. [PMID: 36499624]
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