4-Hydroxybenzoic acid (BioDeep_00000000344)

 

Secondary id: BioDeep_00000228882, BioDeep_00000400084, BioDeep_00000400256, BioDeep_00000403138

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


4-hydroxybenzoic acid

化学式: C7H6O3 (138.0317)
中文名称: 对羟基苯甲酸, 4-羟基苯甲酸
谱图信息: 最多检出来源 Homo sapiens(blood) 19.1%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

4-Hydroxybenzoic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/4-hydroxybenzoic_acid (retrieved 2024-12-31) (BioDeep RN: BioDeep_00000000344). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(=CC=C1C(=O)O)O
InChI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)

描述信息

4-Hydroxybenzoic acid, also known as p-hydroxybenzoate or 4-carboxyphenol, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. Hydroxybenzoic acid derivatives are compounds containing a hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxyl and a hydroxyl groups. 4-Hydroxybenzoic acid is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. It is a nutty and phenolic tasting compound. 4-Hydroxybenzoic acid exists in all living species, ranging from bacteria to plants to humans. 4-Hydroxybenzoic acid can be found naturally in coconut. It is one of the main catechins metabolites found in humans after consumption of green tea infusions. It is also found in wine, in vanilla, in Açaí oil, obtained from the fruit of the açaí palm (Euterpe oleracea), at relatively high concetrations (892±52 mg/kg). It is also found in cloudy olive oil and in the edible mushroom Russula virescens. It has been detected in red huckleberries, rabbiteye blueberries, and corianders and in a lower concentration in olives, red raspberries, and almonds. In humans, 4-hydroxybenzoic acid is involved in ubiquinone biosynthesis. In particular, the enzyme 4-hydroxybenzoate polyprenyltransferase uses a polyprenyl diphosphate and 4-hydroxybenzoate to produce diphosphate and 4-hydroxy-3-polyprenylbenzoate. This enzyme participates in ubiquinone biosynthesis. 4-Hydroxybenzoic acid can be biosynthesized by the enzyme Chorismate lyase. Chorismate lyase is an enzyme that transforms chorismate into 4-hydroxybenzoate and pyruvate. This enzyme catalyses the first step in ubiquinone biosynthesis in Escherichia coli and other Gram-negative bacteria. 4-Hydroxybenzoate is an intermediate in many enzyme-mediated reactions in microbes. For instance, the enzyme 4-hydroxybenzaldehyde dehydrogenase uses 4-hydroxybenzaldehyde, NAD+ and H2O to produce 4-hydroxybenzoate, NADH and H+. This enzyme participates in toluene and xylene degradation in bacteria such as Pseudomonas mendocina. 4-hydroxybenzaldehyde dehydrogenase is also found in carrots. The enzyme 4-hydroxybenzoate 1-hydroxylase transforms 4-hydroxybenzoate, NAD(P)H, 2 H+ and O2 into hydroquinone, NAD(P)+, H2O and CO2. This enzyme participates in 2,4-dichlorobenzoate degradation and is found in Candida parapsilosis. The enzyme 4-hydroxybenzoate 3-monooxygenase transforms 4-hydroxybenzoate, NADPH, H+ and O2 into protocatechuate, NADP+ and H2O. This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation and is found in Pseudomonas putida and Pseudomonas fluorescens. 4-Hydroxybenzoic acid is a popular antioxidant in part because of its low toxicity. 4-Hydroxybenzoic acid has estrogenic activity both in vitro and in vivo (PMID 9417843).
Isolated from many plants, free and combined. Alkyl esters of 4-hydroxybenzoic acid (see below) are used as food and cosmetic preservatives, mainly in their Na salt form, which makes them more water soluble. They are active at low concentrations and more pH-independent than the commonly used Benzoic acid DVN38-Z and 2,4-Hexadienoic acid GMZ10-P. The taste is more detectable than for those preservatives. Effectiveness increases with chain length of the alcohol, but for some microorganisms this reduces cell permeability and thus counteracts the increased efficiency. 4-Hydroxybenzoic acid is found in many foods, some of which are chicory, corn, rye, and black huckleberry.
4-hydroxybenzoic acid is a monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring. It has a role as a plant metabolite and an algal metabolite. It is a conjugate acid of a 4-hydroxybenzoate.
4-Hydroxybenzoic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
See also: Vaccinium myrtillus Leaf (part of); Galium aparine whole (part of); Menyanthes trifoliata leaf (part of) ... View More ...
A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.

4-Hydroxybenzoic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=99-96-7 (retrieved 2024-07-01) (CAS RN: 99-96-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.
4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

同义名列表

95 个代谢物同义名

4-Hydroxybenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material; 4-Hydroxybenzoic acid, certified reference material, TraceCERT(R); InChI=1/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10; 4-Hydroxybenzoic acid, Vetec(TM) reagent grade, 99\\%; 4-hydroxybenzoic acid, monosodium salt, 11C-labeled; METHYL PARAHYDROXYBENZOATE IMPURITY A [EP IMPURITY]; METHYL PARAHYDROXYBENZOATE IMPURITY A (EP IMPURITY); PROPYL HYDROXYBENZOATE IMPURITY A [EP IMPURITY]; PROPYL HYDROXYBENZOATE IMPURITY A (EP IMPURITY); ACETYLSALICYLIC ACID IMPURITY A (EP IMPURITY); ACETYLSALICYLIC ACID IMPURITY A [EP IMPURITY]; 4-Hydroxybenzoic acid, ReagentPlus(R), >=99\\%; 4-Hydroxybenzoic acid, puriss., >=99.0\\% (T); 4-Hydroxybenzoic acid, ReagentPlus(R), 99\\%; 4-hydroxybenzoic acid, copper(2+)(1:1) salt; 4-hydroxybenzoic acid, monopotassium salt; 4-hydroxybenzoic acid, dipotassium salt; SALICYLIC ACID IMPURITY A [EP IMPURITY]; SALICYLIC ACID IMPURITY A (EP IMPURITY); 4-hydroxybenzoic acid, monosodium salt; 4-hydroxybenzoic acid, dilithium salt; sodium p-hydroxybenzoate tetrahydrate; 4-hydroxybenzoic acid, disodium salt; 46DD083D-BFD3-4CE1-B2D9-6C6D5FEFD3D9; 4-hydroxybenzoic acid, calcium salt; Kyselina 4-hydroxybenzoova [Czech]; 4-Hydroxybenzoic acid, >=99\\%, FG; Acido p-idrossibenzoico [Italian]; 4-Hydroxybenzene carboxylic acid; 4-Hydroxybenzoic-2,3,5,6-d4 acid; 4-Hydroxybenzenecarboxylic acid; p-Hydroxybenzoic Acid, Reagent; Hydroxybenzenecarboxylic acid; 4-HYDROXYBENZOIC ACID [INCI]; 4-HYDROXYBENZOIC ACID [FHFI]; 4-HYDROXYBENZOIC ACID [HSDB]; Kyselina 4-hydroxybenzoova; P-HYDROXYBENZOIC ACID [MI]; p-Oxybenzoesaure [German]; Hydroxybenzenecarboxylate; para-hydroxy benzoic acid; HYDROXYBENZOIC ACID, PARA; Benzoic acid, 4-hydroxy-; Benzoic acid, p-hydroxy-; para-hydroxybenzoic acid; Acido p-idrossibenzoico; 4-hydroxyl benzoic acid; parahydroxybenzoic acid; p-Hydroxyl benzoic acid; Benzoic acid, 4-hydroxy; Benzoic acid, p-hydroxy; 4-hydroxylbenzoic acid; 4-Hydroxybenzoate, III; 4-Hydroxy-benzoesaeure; 4-hydroxybenzoi c acid; p-hydroxy benzoic acid; 4-hydroxy-benzoic acid; 4-hydroxy benzoic acid; p-hydroxy-Benzoic acid; p-Hydroxybenzoic acid; 4-Hydroxybenzoic acid; 4-Hydroxybenzoesaeure; phenol derivative, 8; 4-hyroxybenzoic acid; 4-hydoxybenzoic acid; 4-Hydroxybenzoicacid; Hydroxybenzoic acid; 4-hydroxy-benzoate; p-hydroxy-Benzoate; 4-hydroxybenzoate; p-hydroxybenzoate; 4-Hydroxybenzoic; p-Oxybenzoesaure; p-Salicylic acid; 4-Carboxyphenol; UNII-JG8Z55Y12H; Hydroxybenzoate; p-carboxyphenol; Tox21_303301; p-Salicylate; Paraben-acid; Tox21_202342; WLN: QVR DQ; CAS-99-96-7; JG8Z55Y12H; AI3-01003; 4-HBA; PHBA; 3pcc; 3pch; PHB; Sodium 4-hydroxy-benzoate; 4-Hydroxybenzoic acid; 4-Hydroxybenzoate; 4-Hydroxybenzoic acid



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(20)

PlantCyc(3)

代谢反应

527 个相关的代谢反应过程信息。

Reactome(72)

BioCyc(120)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(322)

COVID-19 Disease Map(0)

PathBank(11)

PharmGKB(0)

1435 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, CAT, ESR1, PPARG, TP53, TYR
Peripheral membrane protein 5 ACHE, COQ6, COQ7, CYP1B1, ESR1
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 8 ACHE, AKT1, ALB, COQ7, ESR1, GABPA, PPARG, TP53
cytosol 8 AKT1, ALB, CAT, ESR1, GSR, LIPE, PPARG, TP53
centrosome 2 ALB, TP53
nucleoplasm 5 AKT1, ESR1, GABPA, PPARG, TP53
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 5 ACHE, AKT1, ESR1, LIPE, TNF
Cytoplasmic side 1 ESR1
lamellipodium 1 AKT1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 2 ACHE, TNF
glutamatergic synapse 1 AKT1
Golgi apparatus 4 ACHE, ALB, COQ6, ESR1
Golgi membrane 1 INS
lysosomal membrane 1 GAA
mitochondrial inner membrane 3 COQ6, COQ7, COQ9
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 LIPE
Lysosome 2 GAA, TYR
plasma membrane 6 ACHE, AKT1, BCHE, ESR1, GAA, TNF
Membrane 9 ACHE, AKT1, CAT, COQ7, CYP1B1, ESR1, GAA, LIPE, TP53
caveola 1 LIPE
extracellular exosome 4 ALB, CAT, GAA, GSR
Lysosome membrane 1 GAA
endoplasmic reticulum 2 ALB, TP53
extracellular space 6 ACHE, ALB, BCHE, IL6, INS, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 ACHE, PPARG, TYR
mitochondrion 7 CAT, COQ6, COQ7, COQ9, CYP1B1, GSR, TP53
protein-containing complex 5 AKT1, ALB, CAT, ESR1, TP53
intracellular membrane-bounded organelle 5 CAT, CYP1B1, GAA, PPARG, TYR
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 TYR
Secreted 6 ACHE, ALB, BCHE, GAA, IL6, INS
extracellular region 8 ACHE, ALB, BCHE, CAT, GAA, IL6, INS, TNF
Mitochondrion matrix 1 TP53
mitochondrial matrix 3 CAT, GSR, TP53
Extracellular side 1 ACHE
anchoring junction 1 ALB
transcription regulator complex 2 ESR1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 2 GSR, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Melanosome membrane 1 TYR
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Mitochondrion inner membrane 2 COQ6, COQ7
Matrix side 2 COQ6, COQ7
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
spindle 1 AKT1
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
receptor complex 1 PPARG
ciliary basal body 2 AKT1, ALB
chromatin 4 ESR1, GABPA, PPARG, TP53
cell projection 1 COQ6
phagocytic cup 1 TNF
Chromosome 1 COQ7
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, BCHE
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
Melanosome 1 TYR
euchromatin 1 ESR1
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, BCHE, IL6, INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear envelope lumen 1 BCHE
[Isoform 1]: Nucleus 2 ESR1, TP53
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
ubiquinone biosynthesis complex 3 COQ6, COQ7, COQ9
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
extrinsic component of mitochondrial inner membrane 2 COQ6, COQ7
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xue Gao, Di Xin, Ye Zhao, Junru Li, Yangfan Cao, Shuyong Zhang, Jing Guo. Potential molecular mechanism of photosynthesis regulation by PeMPK7 in poplar under para-hydroxybenzoic acid stress. Ecotoxicology and environmental safety. 2024 May; 276(?):116329. doi: 10.1016/j.ecoenv.2024.116329. [PMID: 38626604]
  • Nozomi Katsuki, Shunsuke Masuo, Noriyuki Nukui, Hajime Minakawa, Naoki Takaya. Gallic acid fermentation by metabolically engineered Escherichia coli producing p-hydroxybenzoate hydroxylase from Hylemonella gracilis NS1. The Journal of general and applied microbiology. 2023 Aug; ?(?):. doi: 10.2323/jgam.2023.08.004. [PMID: 37648467]
  • Michael T Penrose, George P Cobb. Influences of Wastewater Treatment on the Occurrence of Parabens, p-Hydroxybenzoic Acid and Their Chlorinated and Hydroxylated Transformation Products in the Brazos River (Texas, USA). Archives of environmental contamination and toxicology. 2023 Aug; ?(?):. doi: 10.1007/s00244-023-01025-x. [PMID: 37558810]
  • Bitong Zhu, Yuanping Li, Christopher Rensing, Jianghua Ye, Jialin Qiu, Qinji Li, Lekang Wu, Qianxi Lu, Yv Lin, Xiaoli Jia. Improvement of phenolic acid autotoxicity in tea plantations by Pseudomonas fluorescens ZL22. Journal of hazardous materials. 2023 Jun; 458(?):131957. doi: 10.1016/j.jhazmat.2023.131957. [PMID: 37399720]
  • Ke-Na Feng, Yue Zhang, Mingfang Zhang, Yan-Long Yang, Ji-Kai Liu, Lifeng Pan, Ying Zeng. A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone. Nature communications. 2023 06; 14(1):3436. doi: 10.1038/s41467-023-39108-x. [PMID: 37301868]
  • Xiao-Pan Ning, Qian Yao, Zhong-Xiang Xu, Yao Yin, Han Liu, Xiao-Yan Zhang, Tao Ding, Yong Zhang, Yu Hou, Meng-Ru Wang, Li-Na Wu, Qi-Ting Tang. [Determination of seven paraben preservatives in aquatic seasoning using solid-phase extraction coupled with high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2023 Jun; 41(6):513-519. doi: 10.3724/sp.j.1123.2022.10004. [PMID: 37259876]
  • Yi-Xi Li, Wei Lin, Yong-He Han, Yao-Qiang Wang, Tao Wang, Hong Zhang, Yong Zhang, Shan-Shan Wang. Biodegradation of p-hydroxybenzoic acid in Herbaspirillum aquaticum KLS-1 isolated from tailing soil: Characterization and molecular mechanism. Journal of hazardous materials. 2023 May; 456(?):131669. doi: 10.1016/j.jhazmat.2023.131669. [PMID: 37236108]
  • Mohamad Fawzi Mahomoodally, Gokhan Zengin, Seebaluck-Sandoram Roumita, Giovanni Caprioli, Ahmed M Mustafa, Diletta Piatti, Evren Yıldıztugay, Gunes Ak, Ayşe Esra Karadağ, Asaad Khalid, Ashraf N Abdalla, Abdullahi Ibrahim Uba, Fatih Demirci. Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches. Chemistry & biodiversity. 2023 Mar; ?(?):e202201181. doi: 10.1002/cbdv.202201181. [PMID: 36891864]
  • Yaseen Mottiar, Steven D Karlen, Robyn E Goacher, John Ralph, Shawn D Mansfield. Metabolic engineering of p-hydroxybenzoate in poplar lignin. Plant biotechnology journal. 2023 01; 21(1):176-188. doi: 10.1111/pbi.13935. [PMID: 36161690]
  • Yongxi Lin, Dong Li, Chunran Zhou, Yangliu Wu, Peijuan Miao, Qinyong Dong, Shusheng Zhu, Canping Pan. Application of insecticides on peppermint (Mentha × piperita L.) induces lignin accumulation in leaves by consuming phenolic acids and thus potentially deteriorates quality. Journal of plant physiology. 2022 Dec; 279(?):153836. doi: 10.1016/j.jplph.2022.153836. [PMID: 36244262]
  • Wendoline Rosiles-Alanis, Alejandro Zamilpa, Rebeca García-Macedo, Miguel A Zavala-Sánchez, Sergio Hidalgo-Figueroa, Beatriz Mora-Ramiro, Rubén Román-Ramos, Samuel E Estrada-Soto, Julio C Almanza-Perez. 4-Hydroxybenzoic Acid and β-Sitosterol from Cucurbita ficifolia Act as Insulin Secretagogues, Peroxisome Proliferator-Activated Receptor-Gamma Agonists, and Liver Glycogen Storage Promoters: In Vivo, In Vitro, and In Silico Studies. Journal of medicinal food. 2022 Jun; 25(6):588-596. doi: 10.1089/jmf.2021.0071. [PMID: 35708636]
  • Joel B Johnson, Daniel J Skylas, Janice S Mani, Jinle Xiang, Kerry B Walsh, Mani Naiker. Phenolic Profiles of Ten Australian Faba Bean Varieties. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154642. [PMID: 34361795]
  • Y Wang, W Zhang, Z Zhang, W Wang, S Xu, X He. Isolation, identification and characterization of phenolic acid-degrading bacteria from soil. Journal of applied microbiology. 2021 Jul; 131(1):208-220. doi: 10.1111/jam.14956. [PMID: 33270328]
  • Anthi Parla, Eirini Zormpa, Nikolaos Paloumpis, Abuzar Kabir, Kenneth G Furton, Željka Roje, Victoria Samanidou, Ivana Vinković Vrček, Irene Panderi. Determination of Intact Parabens in the Human Plasma of Cancer and Non-Cancer Patients Using a Validated Fabric Phase Sorptive Extraction Reversed-Phase Liquid Chromatography Method with UV Detection. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061526. [PMID: 33799523]
  • Yaling Lu, Xiangping Wu, Lei Yuan, Yingdi Li, Penghui Wang, Jianna Yu, Pingfang Tian, Wenjie Liu. A rapid liquid chromatography-electrospray ionization-ion mobility spectrometry method for monitoring nine representative metabolites in the seedlings of cucumber and wheat. Journal of separation science. 2021 Feb; 44(3):709-716. doi: 10.1002/jssc.202000811. [PMID: 33245598]
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  • Bo Chen, Rui-Fang Li, Lian Zhou, Jia-Hui Qiu, Kai Song, Ji-Liang Tang, Ya-Wen He. The phytopathogen Xanthomonas campestris utilizes the divergently transcribed pobA/pobR locus for 4-hydroxybenzoic acid recognition and degradation to promote virulence. Molecular microbiology. 2020 11; 114(5):870-886. doi: 10.1111/mmi.14585. [PMID: 32757400]
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