Astragalin (BioDeep_00000231186)

Main id: BioDeep_00000003539

Secondary id: BioDeep_00000269963, BioDeep_00000896695

natural product PANOMIX_OTCML-2023 Antitumor activity BioNovoGene_Lab2019


代谢物信息卡片


5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-4-chromenone

化学式: C21H20O11 (448.1006)
中文名称: 紫云英苷、黄芪苷, 山萘酚3-葡萄糖苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)c1ccc(cc1)O)O)O
InChI: InChI=1/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15-,17+,18-,21+/m1/s1

描述信息

Astragalin (Astragaline) a flavonoid with anti-inflammatory, antioxidant, anticancer, bacteriostatic activity. Astragalin inhibits cancer cells proliferation and migration, induces apoptosis. Astragalin is orally active and provides nerve and heart protection, and resistance against and osteoporosis[1].
Astragalin (Astragaline) a flavonoid with anti-inflammatory, antioxidant, anticancer, bacteriostatic activity. Astragalin inhibits cancer cells proliferation and migration, induces apoptosis. Astragalin is orally active and provides nerve and heart protection, and resistance against and osteoporosis[1].

同义名列表

34 个代谢物同义名

5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-4-chromenone; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-chromone; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one; 4H-1-Benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-; 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl beta-D-glucopyranoside; Kaempferol-3-O-.beta.-D-glucopyranoside; 3,4,5,7-Tetrahydroxyflavone-3-glucoside; kaempferol 3-O-beta-D-glucopyranoside; Kaempferol-3-beta-glucopyranoside; Kaempferol 3-O-beta-D-glucoside; Kaempferol-3-beta-monoglucoside; Kaempferol-3-O-glucoside; Kaempferol-3-D-glucoside; Kaempferol 3-O-glucoside; Kaempferol 3-glucoside; NCGC00163580-01; MEGxp0_000168; ACon1_001224; AIDS-051935; CHEBI:30200; Astragaline; Astragalin; AIDS051935; 480-10-4; C12249; K5; kaempferol-3-glucoside; 3- (beta-D-Glucopyranosyloxy) -5,7-dihydroxy-2- (4-hydroxyphenyl) -4H-1-benzopyran-4-one; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside; Kaempferol 3-O-glucoside



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2236 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, ALB, ANXA5, CASP3, CAT, CCND1, MAPK14, MAPK8, NFE2L2, PRKAA2, PTGS2, RELA, TLR4
Peripheral membrane protein 2 ANXA5, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 8 ALB, CASP3, CCND1, MAPK14, MAPK8, NFE2L2, PRKAA2, RELA
cytosol 10 ALB, ANXA5, CASP3, CAT, CCND1, MAPK14, MAPK8, NFE2L2, PRKAA2, RELA
dendrite 1 PRKAA2
centrosome 3 ALB, CCND1, NFE2L2
nucleoplasm 7 CASP3, CCND1, MAPK14, MAPK8, NFE2L2, PRKAA2, RELA
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 2 ABCB1, TLR4
Multi-pass membrane protein 1 ABCB1
Synapse 1 MAPK8
cell surface 2 ABCB1, TLR4
glutamatergic synapse 3 CASP3, MAPK14, RELA
Golgi apparatus 3 ALB, NFE2L2, PRKAA2
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuronal cell body 2 CASP3, PRKAA2
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 GAA
plasma membrane 5 ABCB1, GAA, IFNLR1, NFE2L2, TLR4
Membrane 7 ABCB1, ANXA5, CAT, GAA, IFNLR1, PRKAA2, TLR4
apical plasma membrane 1 ABCB1
axon 3 CCK, MAPK8, PRKAA2
caveola 1 PTGS2
extracellular exosome 6 ABCB1, ALB, ANXA5, BMP3, CAT, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 2 ALB, PTGS2
extracellular space 6 ALB, BMP3, CCK, IL10, IL4, INS
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 TLR4
bicellular tight junction 1 CCND1
mitochondrion 2 CAT, MAPK14
protein-containing complex 3 ALB, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, GAA
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 IFNLR1, TLR4
Secreted 7 ALB, BMP3, CCK, GAA, IL10, IL4, INS
extracellular region 10 ALB, ANXA5, BMP3, CAT, CCK, GAA, IL10, IL4, INS, MAPK14
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 RELA
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 2 ANXA5, TLR4
Early endosome 1 TLR4
Apical cell membrane 1 ABCB1
focal adhesion 2 ANXA5, CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 2 NFE2L2, RELA
mediator complex 1 NFE2L2
phagocytic cup 1 TLR4
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
endosome lumen 1 INS
tertiary granule membrane 1 GAA
cytoplasmic stress granule 1 PRKAA2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, INS, PTGS2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 1 ANXA5
protein-DNA complex 1 NFE2L2
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
catalase complex 1 CAT
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
cyclin D1-CDK4 complex 1 CCND1
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cyclin D1-CDK6 complex 1 CCND1
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Jingya Ruan, Zhongwei Shi, Xiaoyan Cao, Zhunan Dang, Qianqian Zhang, Wei Zhang, Lijie Wu, Yi Zhang, Tao Wang. Research Progress on Anti-Inflammatory Effects and Related Mechanisms of Astragalin. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084476. [PMID: 38674061]
  • Chaoxiang Ren, Ziqing Xi, Bin Xian, Chao Chen, Xulong Huang, Huajuan Jiang, Jiang Chen, Cheng Peng, Jin Pei. Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Carthamus tinctorius L. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16221-16232. doi: 10.1021/acs.jafc.3c05117. [PMID: 37870279]
  • Fangze Xing, Luying Geng, Huanshuai Guan, Donghua Liu, Yiyang Li, Lizhong Zeng, Yang Chen, Run Tian, Zhe Li, Ruomu Cao, Yiwei Zhao, Peng Yan, Hui Qiang, Ning Kong, Kunzheng Wang, Pei Yang. Astragalin mitigates inflammatory osteolysis by negatively modulating osteoclastogenesis via ROS and MAPK signaling pathway. International immunopharmacology. 2022 Nov; 112(?):109278. doi: 10.1016/j.intimp.2022.109278. [PMID: 36215870]
  • Iwona Radziejewska, Katarzyna Supruniuk, Michał Tomczyk, Wiktoria Izdebska, Małgorzata Borzym-Kluczyk, Anna Bielawska, Krzysztof Bielawski, Anna Galicka. p-Coumaric acid, Kaempferol, Astragalin and Tiliroside Influence the Expression of Glycoforms in AGS Gastric Cancer Cells. International journal of molecular sciences. 2022 Aug; 23(15):. doi: 10.3390/ijms23158602. [PMID: 35955735]
  • Ganjayi Muni Swamy, Gunturu Ramesh, Rendedula Devi Prasad, Balaji Meriga. Astragalin, (3-O-glucoside of kaempferol), isolated from Moringa oleifera leaves modulates leptin, adiponectin secretion and inhibits adipogenesis in 3T3-L1 adipocytes. Archives of physiology and biochemistry. 2022 Aug; 128(4):938-944. doi: 10.1080/13813455.2020.1740742. [PMID: 32216601]
  • Guangda Yao, Zijun Bai, Jianguo Niu, Rui Zhang, Youyuan Lu, Tiantian Gao, Hanqing Wang. Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression. Psychopharmacology. 2022 Aug; 239(8):2421-2443. doi: 10.1007/s00213-022-06133-5. [PMID: 35411464]
  • Qigang Fan, Zhongying Zhao, Qing Meng, Ruifeng He, Hongli Li, Meigui Zhang, Pu Gao, Xinlong Li, Yi Li, Qinying Zhu, Fengqin Shen, Lihui Zhao, Xiaolei Liang. Improvement of Astragalin on Spermatogenesis in Oligoasthenozoospermia Mouse Induced by Cyclophosphamide. Reproductive sciences (Thousand Oaks, Calif.). 2022 06; 29(6):1738-1748. doi: 10.1007/s43032-021-00808-8. [PMID: 34846706]
  • Sagar Barge, Barsha Deka, Bhaswati Kashyap, Simanta Bharadwaj, Raghuram Kandimalla, Aparajita Ghosh, Partha Pratim Dutta, Suman Kumar Samanta, Prasenjit Manna, Jagat C Borah, Narayan Chandra Talukdar. Astragalin mediates the pharmacological effects of Lysimachia candida Lindl on adipogenesis via downregulating PPARG and FKBP51 signaling cascade. Phytotherapy research : PTR. 2021 Dec; 35(12):6990-7003. doi: 10.1002/ptr.7320. [PMID: 34734439]
  • Zhongqing Wang, Jian Lv, Xiufang Li, Qing Lin. The flavonoid Astragalin shows anti-tumor activity and inhibits PI3K/AKT signaling in gastric cancer. Chemical biology & drug design. 2021 11; 98(5):779-786. doi: 10.1111/cbdd.13933. [PMID: 34396710]
  • Dahae Lee, Ji-Young Kim, Yutong Qi, Sangsu Park, Hye Lim Lee, Noriko Yamabe, Hocheol Kim, Dae Sik Jang, Ki Sung Kang. Phytochemicals from the flowers of Prunus persica (L.) Batsch: Anti-adipogenic effect of mandelamide on 3T3-L1 preadipocytes. Bioorganic & medicinal chemistry letters. 2021 10; 49(?):128326. doi: 10.1016/j.bmcl.2021.128326. [PMID: 34403725]
  • ShaoLi Lyu, Wang Wang. Spectroscopic methodologies and computational simulation studies on the characterization of the interaction between human serum albumin and astragalin. Journal of biomolecular structure & dynamics. 2021 May; 39(8):2959-2970. doi: 10.1080/07391102.2020.1758213. [PMID: 32306829]
  • Dong Gu Lee, Ju Sung Lee, Norman G Quilantang, Sonia D Jacinto, Sanghyun Lee. Determination of Afzelin and Astragalin from Lespedeza cuneata on Aldose Reductase Inhibition. Journal of chromatographic science. 2021 Mar; 59(4):381-387. doi: 10.1093/chromsci/bmaa127. [PMID: 33420504]
  • Zhen-Wang Zhao, Min Zhang, Gang Wang, Jin Zou, Jia-Hui Gao, Li Zhou, Xiang-Jun Wan, Da-Wei Zhang, Xiao-Hua Yu, Chao-Ke Tang. Astragalin Retards Atherosclerosis by Promoting Cholesterol Efflux and Inhibiting the Inflammatory Response via Upregulating ABCA1 and ABCG1 Expression in Macrophages. Journal of cardiovascular pharmacology. 2021 02; 77(2):217-227. doi: 10.1097/fjc.0000000000000944. [PMID: 33165140]
  • Mohamed A Alblihed. Astragalin attenuates oxidative stress and acute inflammatory responses in carrageenan-induced paw edema in mice. Molecular biology reports. 2020 Sep; 47(9):6611-6620. doi: 10.1007/s11033-020-05712-z. [PMID: 32770524]
  • Lin Zheng, Yueting Li, Zuying Zhou, Wenying Xiang, Zipeng Gong, Siying Chen, Yonglin Wang, Aimin Wang, Yanyu Lan, Yongjun Li, Yong Huang. Comparative pharmacokinetics of quercitrin, astragalin, afzelin and taxifolin in plasma after oral administration of Polygonum orientale inflorescence in sham-operated and myocardial ischemia-reperfusion injury rats. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Jul; 50(7):822-830. doi: 10.1080/00498254.2019.1700319. [PMID: 31791186]
  • Changqin Li, Miyun Hu, Shengjun Jiang, Zhenhua Liang, Jinmei Wang, Zhenhua Liu, Hui-Min David Wang, Wenyi Kang. Evaluation Procoagulant Activity and Mechanism of Astragalin. Molecules (Basel, Switzerland). 2020 Jan; 25(1):. doi: 10.3390/molecules25010177. [PMID: 31906332]
  • Keshab Kumar Karna, Bo Ram Choi, Jae Hyung You, Yu Seob Shin, Wan Shou Cui, Sung Won Lee, Ji Hoon Kim, Chul Young Kim, Hye Kyung Kim, Jong Kwan Park. The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats. BMC complementary and alternative medicine. 2019 Nov; 19(1):333. doi: 10.1186/s12906-019-2736-9. [PMID: 31771569]
  • Chien-Chang Shen, Wen-Chi Wei, Lie-Chwen Lin. Diterpenoids and Bisnorditerpenoids from Blumea aromatica. Journal of natural products. 2019 11; 82(11):3181-3185. doi: 10.1021/acs.jnatprod.9b00674. [PMID: 31646857]
  • Jin Zeng, Rui-Jing Ma, Ling Wang, Sheng-Nan Zhang, Hong-Zhi Song, Yang Yang, Qin-Gang Tan. Chemical constituents from the leaves of Melia azedarach. Natural product research. 2019 Oct; 33(19):2860-2863. doi: 10.1080/14786419.2018.1501690. [PMID: 30445850]
  • Xin Meng, Aihua Zhang, Xijun Wang, Hui Sun. A kaempferol-3-O-β-d-glucoside, intervention effect of astragalin on estradiol metabolism. Steroids. 2019 09; 149(?):108413. doi: 10.1016/j.steroids.2019.05.005. [PMID: 31152828]
  • Donghua Zheng, Dawei Liu, Na Liu, Yukun Kuang, Qiang Tai. Astragalin reduces lipopolysaccharide-induced acute lung injury in rats via induction of heme oxygenase-1. Archives of pharmacal research. 2019 Aug; 42(8):704-711. doi: 10.1007/s12272-019-01171-8. [PMID: 31250343]
  • Diana Rey, Paola Miranda Sulis, Thaís Alves Fernandes, Renata Gonçalves, Marisa Jádna Silva Frederico, Geison M Costa, Marcela Aragon, Luís Fernando Ospina, Fátima Regina Mena Barreto Silva. Astragalin augments basal calcium influx and insulin secretion in rat pancreatic islets. Cell calcium. 2019 06; 80(?):56-62. doi: 10.1016/j.ceca.2019.03.009. [PMID: 30965223]
  • Litong Zhu, Linfeng Zhu, Junzhe Chen, Tongxia Cui, Weitang Liao. Astragalin induced selective kidney cancer cell death and these effects are mediated via mitochondrial mediated cell apoptosis, cell cycle arrest, and modulation of key tumor-suppressive miRNAs. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2019 May; 24(3):1245-1251. doi: . [PMID: 31424686]
  • Magdy Kazzem, Yu-Ting Sun, Mitchell Low, Sai Wang Seto, Dennis Chang, Samiuela Lee, Harsha Suresh, Cheang S Khoo, Alan Bensoussan, Hosen Kiat. Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves. Molecules (Basel, Switzerland). 2019 Mar; 24(6):. doi: 10.3390/molecules24061101. [PMID: 30897753]
  • KyoHee Cho, Min Cheol Kang, Amna Parveen, Silvia Yumnam, Sun Yeou Kim. Anti-Inflammatory Effect of Chloroform Fraction of Pyrus Ussuriensis Maxim. Leaf Extract on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis in nc/nga Mice. Nutrients. 2019 Jan; 11(2):. doi: 10.3390/nu11020276. [PMID: 30691219]
  • Dong Wu, Danmeng Yu, Yujia Zhang, Juane Dong, Dengwu Li, Dongmei Wang. Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Eucommia ulmoides Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree. Molecules (Basel, Switzerland). 2018 Jul; 23(8):. doi: 10.3390/molecules23081898. [PMID: 30061494]
  • Pham Thi Nhat Trinh, Nguyen Huu An, Pham Ngoc An, Mai Dinh Tri, Cao Van Du, Phan Nhat Minh, Nguyen Thi Le Thuy, Nguyen Trong Tuan, Vang Thi Kim Thoa, Nguyen Ngoc Tuan, Le Tien Dung. A new benzofuran derivative from the leaves of Ficus pumila L. Natural product research. 2018 Jul; 32(14):1648-1652. doi: 10.1080/14786419.2017.1395427. [PMID: 29072969]
  • Jiwon Baek, Dahae Lee, Tae Kyoung Lee, Ji Hoon Song, Ju Sung Lee, Seong Lee, Sang-Woo Yoo, Ki Sung Kang, Eunjung Moon, Sanghyun Lee, Ki Hyun Kim. (-)-9'-O-(α-l-Rhamnopyranosyl)lyoniresinol from Lespedeza cuneata suppresses ovarian cancer cell proliferation through induction of apoptosis. Bioorganic & medicinal chemistry letters. 2018 01; 28(2):122-128. doi: 10.1016/j.bmcl.2017.11.045. [PMID: 29223588]
  • Na Li, Wei-Lin Zeng, Xu-Lu Luo, Chong-Ren Yang, Ying-Jun Zhang, Yong Ding, Ping Zhao. A new arbutin derivative from the leaves of Vaccinium dunalianum wight. Natural product research. 2018 Jan; 32(1):65-70. doi: 10.1080/14786419.2017.1333993. [PMID: 28595463]
  • Wei Xiao, Yude Peng, Zhexu Tan, Qiuyue Lv, Chi-On Chan, Jingyu Yang, Sibao Chen. Comparative Evaluation of Chemical Profiles of Pyrrosiae Folium Originating from Three Pyrrosia Species by HPLC-DAD Combined with Multivariate Statistical Analysis. Molecules (Basel, Switzerland). 2017 Dec; 22(12):. doi: 10.3390/molecules22122122. [PMID: 29194397]
  • Xin Li, Zichen Tang, Dongqing Fei, Yunhong Liu, Min Zhang, Shaoyang Liu. Evaluation of the sedative and hypnotic effects of astragalin isolated from Eucommia ulmoides leaves in mice. Natural product research. 2017 Sep; 31(17):2072-2076. doi: 10.1080/14786419.2016.1272108. [PMID: 28013568]
  • Xiaofeng Yu, Yiling Zhu, Jingyi Fan, Dujun Wang, Xiaohui Gong, Zhen Ouyang. Accumulation of Flavonoid Glycosides and UFGT Gene Expression in Mulberry Leaves (Morus alba L.) before and after Frost. Chemistry & biodiversity. 2017 Aug; 14(8):. doi: 10.1002/cbdv.201600496. [PMID: 28281324]
  • Juanqiang Wang, Shan Geng, Binghai Wang, Qian Shao, Yingtong Fang, Yun Wei. Magnetic nanoparticles and high-speed countercurrent chromatography coupled in-line and using the same solvent system for separation of quercetin-3-O-rutinoside, luteoloside and astragalin from a Mikania micrantha extract. Journal of chromatography. A. 2017 Jul; 1508(?):42-52. doi: 10.1016/j.chroma.2017.05.062. [PMID: 28602506]
  • Wei Li, Ji Hao, Lang Zhang, Zhuo Cheng, Xukun Deng, Guangwen Shu. Astragalin Reduces Hexokinase 2 through Increasing miR-125b to Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Vitro and in Vivo. Journal of agricultural and food chemistry. 2017 Jul; 65(29):5961-5972. doi: 10.1021/acs.jafc.7b02120. [PMID: 28654261]
  • Xican Li, Yage Tian, Tingting Wang, Qiaoqi Lin, Xiaoyi Feng, Qian Jiang, Yamei Liu, Dongfeng Chen. Role of the p-Coumaroyl Moiety in the Antioxidant and Cytoprotective Effects of Flavonoid Glycosides: Comparison of Astragalin and Tiliroside. Molecules (Basel, Switzerland). 2017 Jul; 22(7):. doi: 10.3390/molecules22071165. [PMID: 28704976]
  • Wenlong Zhang, Xiaojie Lu, Wei Wang, Zhuang Ding, Yunhe Fu, Xiaofei Zhou, Naisheng Zhang, Yongguo Cao. Inhibitory Effects of Emodin, Thymol, and Astragalin on Leptospira interrogans-Induced Inflammatory Response in the Uterine and Endometrium Epithelial Cells of Mice. Inflammation. 2017 Apr; 40(2):666-675. doi: 10.1007/s10753-017-0513-9. [PMID: 28210912]
  • Sanawar Mansur, Rahima Abdulla, Amatjan Ayupbec, Haji Akbar Aisa. Chemical Fingerprint Analysis and Quantitative Analysis of Rosa rugosa by UPLC-DAD. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121754. [PMID: 28009848]
  • Min Wei, Gail B Mahady, Daniel Liu, Zhi S Zheng, Ye Lu. Astragalin, a Flavonoid from Morus alba (Mulberry) Increases Endogenous Estrogen and Progesterone by Inhibiting Ovarian Granulosa Cell Apoptosis in an Aged Rat Model of Menopause. Molecules (Basel, Switzerland). 2016 May; 21(5):. doi: 10.3390/molecules21050675. [PMID: 27213327]
  • Haifeng Li, Ruona Shi, Fei Ding, Hongyu Wang, Wenjing Han, Fangli Ma, Minghua Hu, Chung Wah Ma, Zebo Huang. Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans. Oxidative medicine and cellular longevity. 2016; 2016(?):4856761. doi: 10.1155/2016/4856761. [PMID: 27885333]
  • Daoxu Qu, Jichun Han, Huanhuan Ren, Wenxiao Yang, Xinjie Zhang, Qiusheng Zheng, Dong Wang. Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart. Oxidative medicine and cellular longevity. 2016; 2016(?):8194690. doi: 10.1155/2016/8194690. [PMID: 26788251]
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