Protocatechuic acid (BioDeep_00000000138)

 

Secondary id: BioDeep_00000400089, BioDeep_00000859384

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs BioNovoGene_Lab2019


代谢物信息卡片


3,4-dihydroxybenzoic acid

化学式: C7H6O4 (154.0266)
中文名称: 3,4-二羟基苯甲酸, 原儿茶酸
谱图信息: 最多检出来源 Homo sapiens(feces) 32.17%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Protocatechuic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/protocatechuic_acid (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000000138). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(c(cc(cc1)C(=O)O)O)O
InChI: InChI=1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)

描述信息

Protocatechuic acid, also known as protocatechuate or 3,4-dihydroxybenzoate, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. Hydroxybenzoic acid derivatives are compounds containing a hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxyl and a hydroxyl groups. The enzyme protocatechuate 3,4-dioxygenase uses 3,4-dihydroxybenzoate and O2 to produce 3-carboxy-cis,cis-muconate. Protocatechuic acid is a drug. In the analogous hardening of the cockroach ootheca, the phenolic substance concerned is protocatechuic acid. Protocatechuic acid is a mild, balsamic, and phenolic tasting compound. Outside of the human body, protocatechuic acid is found, on average, in the highest concentration in a few different foods, such as garden onions, cocoa powders, and star anises and in a lower concentration in lentils, liquors, and red raspberries. Protocatechuic acid has also been detected, but not quantified in several different foods, such as cloud ear fungus, american pokeweeds, common mushrooms, fruits, and feijoa. This could make protocatechuic acid a potential biomarker for the consumption of these foods. It is also found in Allium cepa (17,540 ppm). It is a major metabolite of antioxidant polyphenols found in green tea. Similarly, PCA was reported to increase proliferation and inhibit apoptosis of neural stem cells. In vitro testing documented antioxidant and anti-inflammatory activity of PCA, while liver protection in vivo was measured by chemical markers and histological assessment.
3,4-dihydroxybenzoic acid, also known as protocatechuic acid or 4-carboxy-1,2-dihydroxybenzene, belongs to hydroxybenzoic acid derivatives class of compounds. Those are compounds containing a hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxyl and a hydroxyl groups. 3,4-dihydroxybenzoic acid is soluble (in water) and a weakly acidic compound (based on its pKa). 3,4-dihydroxybenzoic acid can be synthesized from benzoic acid. 3,4-dihydroxybenzoic acid is also a parent compound for other transformation products, including but not limited to, methyl 3,4-dihydroxybenzoate, ethyl 3,4-dihydroxybenzoate, and 1-(3,4-dihydroxybenzoyl)-beta-D-glucopyranose. 3,4-dihydroxybenzoic acid is a mild, balsamic, and phenolic tasting compound and can be found in a number of food items such as white mustard, grape wine, abalone, and asian pear, which makes 3,4-dihydroxybenzoic acid a potential biomarker for the consumption of these food products. 3,4-dihydroxybenzoic acid can be found primarily in blood, feces, and urine, as well as in human fibroblasts and testes tissues. 3,4-dihydroxybenzoic acid exists in all eukaryotes, ranging from yeast to humans. Protocatechuic acid (PCA) is a dihydroxybenzoic acid, a type of phenolic acid. It is a major metabolite of antioxidant polyphenols found in green tea. It has mixed effects on normal and cancer cells in in vitro and in vivo studies .
3,4-dihydroxybenzoic acid is a dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4. It has a role as a human xenobiotic metabolite, a plant metabolite, an antineoplastic agent, an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor and an EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor. It is a member of catechols and a dihydroxybenzoic acid. It is functionally related to a benzoic acid. It is a conjugate acid of a 3,4-dihydroxybenzoate.
3,4-Dihydroxybenzoic acid is a natural product found in Visnea mocanera, Amomum subulatum, and other organisms with data available.
Protocatechuic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
See also: Black Cohosh (part of); Vaccinium myrtillus Leaf (part of); Menyanthes trifoliata leaf (part of) ... View More ...
A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.

Protocatechuic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=99-50-3 (retrieved 2024-06-29) (CAS RN: 99-50-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.
Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.

同义名列表

62 个代谢物同义名

Protocatechuic acid, United States Pharmacopeia (USP) Reference Standard; Protocatechuic acid, primary pharmaceutical reference standard; InChI=1/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11; 3,4-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 97\\%; PROTOCATECHOIC ACID (CONSTITUENT OF MARITIME PINE) [DSC]; PROTOCATECHOIC ACID (CONSTITUENT OF MARITIME PINE); 3,4-dihydroxybenzoate;3,4-Dihydroxybenzoic acid; 3,4-Dihydroxybenzoic acid, analytical standard; DROXIDOPA METABOLITE (PROTOCATECHOIC ACID); protocatechuic acid, carboxy-14C-labeled; 3,4-Dihydroxybenzoic acid, >=97.0\\% (T); 1,2-Dihydroxybenzene-4-carboxylic acid; protocatechuic acid, monosodium salt; 3,4-DIHYDROXYBENZOIC ACID [INCI]; Pyrocatechol-4-carboxylic Acid; 4-Carboxy-1,2-dihydroxybenzene; Benzoic acid, 3,4-dihydroxy-; DIHYDROXYBENZOIC ACID, 3,4-; 3,4-Dihydroxybenzoate, VIII; 3, 4-Dihydroxybenzoic acid; Catechol-4-carboxylic Acid; 3,4-Dihydroxy Benzoic Acid; 3,4-dihydroxy-benzoic acid; 4,5-Dihydroxybenzoic acid; 3,4-Dihydroxybenzoic acid; PROTOCATECHUIC ACID (PCA); 2,4-dihydroxybenzoic acid; Protocatechuic acid (M1); PROTOCATECHUIC ACID [MI]; Protocatechuic Acid,(S); Carbohydroquinonic acid; 4,5-Dihydroxybenzoate; 3,4-dihydroxybenzoate; 2,4-Dihydroxybenzoate; beta-Resorcylic acid; Proto-catechuic acid; Protacatechuic Acid; protocatechuic acid; PROTOCATECHOIC ACID; protocatechuicacid; Protocatehuic acid; ProtocatechicAcid; b-resorcylic acid; beta-Resorcylate; protocatechuate; Hypogallic acid; UNII-36R5QJ8L4B; Protocatehuate; Protocatechuic; b-Resorcylate; ZINCSELENITE; Tox21_200167; CAS-99-50-3; KSC-10-128; 36R5QJ8L4B; 3,4-DHBA; cid_72; 1ykp; 4fht; Protocatechuic acid; 3,4-Dihydroxybenzoate; 3,4-Dihydroxybenzoic acid



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

46 个相关的代谢反应过程信息。

Reactome(44)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1482 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, APOE, BCL2, HPGDS, MAPK14, MAPK8, NFE2L2, PIK3CA, PTGS2, RELA, SYK, TLR4, TYR, VEGFA
Peripheral membrane protein 3 ACHE, HSD17B6, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 10 ACHE, AKT1, APOE, BCL2, MAPK14, MAPK8, NFE2L2, RELA, SYK, VEGFA
cytosol 10 AKT1, BCL2, GPT, HPGDS, MAPK14, MAPK8, NFE2L2, PIK3CA, RELA, SYK
dendrite 1 APOE
centrosome 1 NFE2L2
nucleoplasm 6 AKT1, HPGDS, MAPK14, MAPK8, NFE2L2, RELA
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 ACHE, AKT1, SYK, TLR4
lamellipodium 2 AKT1, PIK3CA
Early endosome membrane 1 HSD17B6
Synapse 2 ACHE, MAPK8
cell cortex 1 AKT1
cell surface 3 ACHE, TLR4, VEGFA
glutamatergic synapse 4 AKT1, APOE, MAPK14, RELA
Golgi apparatus 4 ACHE, APOE, NFE2L2, VEGFA
neuromuscular junction 1 ACHE
neuronal cell body 1 APOE
postsynapse 1 AKT1
Cytoplasm, cytosol 2 NFE2L2, SYK
Lysosome 1 TYR
plasma membrane 7 ACHE, AKT1, APOE, NFE2L2, PIK3CA, SYK, TLR4
Membrane 6 ACHE, AKT1, APOE, BCL2, TLR4, VEGFA
axon 2 CCK, MAPK8
caveola 1 PTGS2
extracellular exosome 2 APOE, GPT
Lumenal side 1 HSD17B6
endoplasmic reticulum 5 APOE, BCL2, HSD17B6, PTGS2, VEGFA
extracellular space 6 ACHE, APOE, CCK, CCL2, CXCL8, VEGFA
perinuclear region of cytoplasm 4 ACHE, PIK3CA, TLR4, TYR
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, MAPK14
protein-containing complex 4 AKT1, BCL2, PTGS2, SYK
intracellular membrane-bounded organelle 3 HPGDS, HSD17B6, TYR
Microsome membrane 2 HSD17B6, PTGS2
Single-pass type I membrane protein 2 TLR4, TYR
Secreted 6 ACHE, APOE, CCK, CCL2, CXCL8, VEGFA
extracellular region 7 ACHE, APOE, CCK, CCL2, CXCL8, MAPK14, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Extracellular side 1 ACHE
transcription regulator complex 1 RELA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TLR4
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 2 APOE, VEGFA
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
microtubule cytoskeleton 1 AKT1
Melanosome membrane 1 TYR
Early endosome 2 APOE, TLR4
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
vesicle 1 AKT1
pore complex 1 BCL2
spindle 1 AKT1
extracellular matrix 2 APOE, VEGFA
basement membrane 1 ACHE
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 APOE
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, RELA
mediator complex 1 NFE2L2
phagocytic cup 1 TLR4
Secreted, extracellular space 1 APOE
spindle pole 1 MAPK14
blood microparticle 1 APOE
Lipid-anchor, GPI-anchor 1 ACHE
Melanosome 2 APOE, TYR
side of membrane 1 ACHE
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 APOE, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 2 ACHE, APOE
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
early phagosome 1 SYK
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
T cell receptor complex 1 SYK
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
BAD-BCL-2 complex 1 BCL2
B cell receptor complex 1 SYK
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
NF-kappaB p50/p65 complex 1 RELA
[Isoform H]: Cell membrane 1 ACHE
NF-kappaB complex 1 RELA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Teresa Deuchande, Joana F Fundo, Manuela E Pintado, Ana L Amaro. Protocatechuic acid as an inhibitor of lipid oxidation in meat. Meat science. 2024 Jul; 213(?):109519. doi: 10.1016/j.meatsci.2024.109519. [PMID: 38663116]
  • Karolina Jafernik, Paweł Kubica, Marta Sharafan, Aleksandra Kruk, Magdalena Anna Malinowska, Sebastian Granica, Agnieszka Szopa. Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures. Applied microbiology and biotechnology. 2024 May; 108(1):322. doi: 10.1007/s00253-024-13159-6. [PMID: 38713216]
  • Cem Baltacıoğlu, Hande Baltacıoğlu, İlhami Okur, Mehmet Yetişen, Hami Alpas. Recovery of phenolic compounds from peach pomace using conventional solvent extraction and different emerging techniques. Journal of food science. 2024 Mar; 89(3):1672-1683. doi: 10.1111/1750-3841.16972. [PMID: 38343298]
  • Jasmin Bayer, Petra Högger. Development and validation of a LC-MS/MS method for the quantification of phenolic compounds in human saliva after intake of a procyanidin-rich pine bark extract. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115914. doi: 10.1016/j.jpba.2023.115914. [PMID: 38101241]
  • Avery C Vilbert, Wayne S Kontur, Derek Gille, Daniel R Noguera, Timothy J Donohue. Engineering Novosphingobium aromaticivorans to produce cis,cis-muconic acid from biomass aromatics. Applied and environmental microbiology. 2024 Jan; 90(1):e0166023. doi: 10.1128/aem.01660-23. [PMID: 38117061]
  • Huafang Ding, Jianhui Liu, Zixing Chen, Shouhe Huang, Chi Yan, Erika Kwek, Zouyan He, Hanyue Zhu, Zhen-Yu Chen. Protocatechuic acid alleviates TMAO-aggravated atherosclerosis via mitigating inflammation, regulating lipid metabolism, and reshaping gut microbiota. Food & function. 2024 Jan; 15(2):881-893. doi: 10.1039/d3fo04396g. [PMID: 38165856]
  • Ning Li, Xia Du, Tong Qu, Hui Ren, Wenjing Lu, Xiaomin Cui, Jing Hu, Zhiyong Chen, Hongxun Tao. Pharmacodynamic material basis and pharmacological mechanisms of Cortex Mori against diabetes mellitus. Journal of ethnopharmacology. 2024 Jan; 324(?):117781. doi: 10.1016/j.jep.2024.117781. [PMID: 38253278]
  • Emad Hamdy Khedr, Nagwa Khedr. Enhancing productivity, modifying biochemical parameters, and regulating the phenylpropanoid pathway in 'Le-Conte' pears through optimal protocatechuic acid treatments. BMC plant biology. 2024 Jan; 24(1):50. doi: 10.1186/s12870-023-04715-9. [PMID: 38221634]
  • Inés Domínguez-López, Polina Galkina, Isabella Parilli-Moser, Camila Arancibia-Riveros, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Mireia Malcampo, J Alfredo Martínez, Lucas Tojal-Sierra, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Manuel Santos-Lozano, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A Tur, María Rubín-García, Xavier Pintó, Fernando Fernández-Aranda, Miguel Delgado-Rodríguez, Ana Barabash-Bustelo, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Estefania Toledo, Alessandro Atzeni, Eva M Asensio, Natàlia Vera, Antonio Garcia-Rios, Laura Torres-Collado, Napoleón Pérez-Farinós, Marian Zulet, Alice Chaplin, Rosa Casas, Sandra Martín-Peláez, Jessica Vaquero-Luna, Ana Maria Gómez-Pérez, Zenaida Vázquez-Ruiz, Sangeetha Shyam, Carolina Ortega-Azorín, Natàlia Talens, Patricia J Peña-Orihuela, Alejandro Oncina-Canovas, Javier Diez-Espino, Nancy Babio, Montserrat Fitó, Rosa M Lamuela-Raventós. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health. Molecular nutrition & food research. 2024 Jan; 68(2):e2300183. doi: 10.1002/mnfr.202300183. [PMID: 38062915]
  • Folake Asejeje, Sylvia Etim, Gbolahan Asejeje, Benneth Chukwudi Iwuoh, Sanmi Ibukunoluwa Akintade, Isaac Adedara, Ebenezer Olatunde Farombi. Protocatechuic acid modulates hepatic oxidative stress and inflammation linked to DMN exposure in rat. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2023 Dec; 38(2):145-155. doi: 10.54548/njps.v38i2.4. [PMID: 38696681]
  • Kaixia Xu, Guang Lu, Qianjin Feng, Shuangchao Chen, Yonghui Wang. Hepatoprotective effect of protocatechuic acid against type 2 diabetes-induced liver injury. Pharmaceutical biology. 2023 Dec; 61(1):737-745. doi: 10.1080/13880209.2023.2181359. [PMID: 37129023]
  • Huiqing Piao, Wanchen Xie, Shiqi Li, Jiaqi Wang, Chao Liu, Peng Quan, Liang Fang. Ternary Deep Eutectic Solvents System of Colchicine, 4-Hydroxyacetophenone, and Protocatechuic Acid and Characterization of Transdermal Enhancement Mechanism. AAPS PharmSciTech. 2023 Nov; 24(8):229. doi: 10.1208/s12249-023-02681-x. [PMID: 37964102]
  • Chun-Yan Yin, Yuan-Pei Lian, Jian-Da Xu, Chan-Ming Liu, Jia-Li Cai, Li Zhu, Di-Jun Wang, Li-Bo Luo, Xiao-Jing Yan. Study on network pharmacology of Ginkgo biloba extract against ischaemic stroke mechanism and establishment of UPLC-MS/MS methods for simultaneous determination of 19 main active components. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3286. [PMID: 37758241]
  • Nozomi Katsuki, Shunsuke Masuo, Noriyuki Nukui, Hajime Minakawa, Naoki Takaya. Gallic acid fermentation by metabolically engineered Escherichia coli producing p-hydroxybenzoate hydroxylase from Hylemonella gracilis NS1. The Journal of general and applied microbiology. 2023 Aug; ?(?):. doi: 10.2323/jgam.2023.08.004. [PMID: 37648467]
  • Tongjie Xiao, Mingyu Pan, Yuanxiao Wang, Yanjiao Huang, Makoto Tsunoda, Yingxia Zhang, Rong Wang, Wenting Hu, Haimei Yang, Lu-Shuang Li, Yanting Song. In vitro bloodbrain barrier permeability study of four main active ingredients from Alpiniae oxyphyllae fructus. Journal of pharmaceutical and biomedical analysis. 2023 Aug; 235(?):115637. doi: 10.1016/j.jpba.2023.115637. [PMID: 37634356]
  • Michael Sgro, Nicholas Chow, Farnaz Olyaie, Mark Arentshorst, Nicholas Geoffrion, Arthur F J Ram, Justin Powlowski, Adrian Tsang. Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger. The Journal of biological chemistry. 2023 Jul; ?(?):105003. doi: 10.1016/j.jbc.2023.105003. [PMID: 37399977]
  • Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis. Journal of ethnopharmacology. 2023 Jun; 310(?):116367. doi: 10.1016/j.jep.2023.116367. [PMID: 36914037]
  • Jin Li, Jianli Fu, Cheng Yue, Yanzhe Shang, Bang-Ce Ye. Highly Efficient Biosynthesis of Protocatechuic Acid via Recombinant Pseudomonas putida KT2440. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c01511. [PMID: 37365996]
  • Qiaoli Zhao, Liuping Fan, Jinwei Li. High internal phase emulsion gels stabilized by phosphorylated perilla protein isolate for protecting hydrophobic nutrients: Adjusting emulsion performance by incorporating chitosan-protocatechuic acid conjugate. International journal of biological macromolecules. 2023 Jun; 239(?):124101. doi: 10.1016/j.ijbiomac.2023.124101. [PMID: 36958452]
  • Sen Shi, Jiabo Cheng, Naveed Ahmad, Wenyan Zhao, Mengfei Tian, Zhanyu Yuan, Chunying Li, Chunjian Zhao. Effects of potential allelochemicals in a water extract of Abutilon theophrasti Medik. on germination and growth of Glycine max L., Triticum aestivum L., and Zea mays L. Journal of the science of food and agriculture. 2023 Mar; 103(4):2155-2165. doi: 10.1002/jsfa.12315. [PMID: 36369956]
  • Qiaoli Zhao, Liuping Fan, Yulin Zhou, Jinwei Li. Effect of chitosan-protocatechuic acid conjugate on stability and encapsulation capacity of polysaccharide-based high internal phase emulsion. Carbohydrate polymers. 2023 Mar; 304(?):120487. doi: 10.1016/j.carbpol.2022.120487. [PMID: 36641160]
  • Abeer Salama, Rania Elgohary, Mohamed M Amin, Sahar Abd Elwahab. Impact of protocatechuic acid on alleviation of pulmonary damage induced by cyclophosphamide targeting peroxisome proliferator activator receptor, silent information regulator type-1, and fork head box protein in rats. Inflammopharmacology. 2023 Mar; ?(?):. doi: 10.1007/s10787-023-01156-6. [PMID: 36877411]
  • Yuyao Xiang, Ruolan Huang, Yongliang Wang, Shanshan Han, Xiaochen Qin, Zhenzhen Li, Xu Wang, Yuqing Han, Tao Wang, Bo Xia, Jiangwei Wu, Gongshe Yang. Protocatechuic Acid Ameliorates High Fat Diet-Induced Obesity and Insulin Resistance in Mice. Molecular nutrition & food research. 2023 Feb; 67(3):e2200244. doi: 10.1002/mnfr.202200244. [PMID: 36285395]
  • Yan Liu, Yucheng Zhang, Keke Zhang, Yue Wang. Protocatechuic acid reduces H2O2-induced migration and oxidative stress of fibroblast-like synoviocytes in rheumatoid arthritis by activating Nrf2-Keap1 signaling pathway. The Chinese journal of physiology. 2023 Jan; 66(1):28-35. doi: 10.4103/cjop.cjop-d-22-00087. [PMID: 36814154]
  • Jijun Tan, Ruizhi Hu, Jiatai Gong, Chengkun Fang, Yanli Li, Ming Liu, Ziyu He, De-Xing Hou, Hongfu Zhang, Jianhua He, Shusong Wu. Protection against Metabolic Associated Fatty Liver Disease by Protocatechuic Acid. Gut microbes. 2023 Jan; 15(1):2238959. doi: 10.1080/19490976.2023.2238959. [PMID: 37505920]
  • Qian Zhang, Meixuan Li, Guiyan Yang, Xiaoqiang Liu, Zhongdong Yu, Shaobing Peng. Protocatechuic acid, ferulic acid and relevant defense enzymes correlate closely with walnut resistance to Xanthomonas arboricola pv. juglandis. BMC plant biology. 2022 Dec; 22(1):598. doi: 10.1186/s12870-022-03997-9. [PMID: 36539704]
  • Yajun Shen, Hengyang Li, Ding Xiaoying, Zhilai Zhan, Qi An, Yuguang Zheng, Dan Zhang. Optimization of Extraction and Quality Evaluation of Abri Herba by Response Surface Methodology Combined with Quantitative Analysis of Multi-Components by Single Marker. Journal of AOAC International. 2022 Nov; ?(?):. doi: 10.1093/jaoacint/qsac149. [PMID: 36383190]
  • Kendal Erdem Duman, Abdulahad Dogan, Burak Kaptaner. Ameliorative role of Cyanus depressus (M.Bieb.) Soják plant extract against diabetes-associated oxidative-stress-induced liver, kidney, and pancreas damage in rats. Journal of food biochemistry. 2022 10; 46(10):e14314. doi: 10.1111/jfbc.14314. [PMID: 35802765]
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