Chlorogenic Acid (BioDeep_00000290658)

Main id: BioDeep_00000000242

Secondary id: BioDeep_00000033581, BioDeep_00000861008

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Malonyl-caffeoylquinic acid

化学式: C16H18O9 (354.0951)
中文名称: 绿原酸
谱图信息: 最多检出来源 Viridiplantae(plant) 20.77%

分子结构信息

SMILES: C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O
InChI: InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14+,16?/m1/s1

描述信息

IPB_RECORD: 1901; CONFIDENCE confident structure
Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound[1][2][3].
Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.

同义名列表

10 个代谢物同义名

Chlorogenic Acid; 5-caffeoyl quinic acid; 5-Caffeoylquinic acid; 3-O-Caffeoylquinic acid; 3-Caffeoylquinic acids; 3-Caffeoylquinic acid; Malonyl-caffeoylquinic acid; Heriguard; NSC-407296; Chlorogenate



数据库引用编号

77 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1980 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ELANE, FASN, HPGDS, NOS2, NOS3, NQO1, STAT3, TYR, VEGFA, XDH
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 HMGCR
Nucleus 6 ACHE, NOS2, NOS3, NQO1, STAT3, VEGFA
cytosol 10 ELANE, FASN, HPGDS, LEP, LIPE, NOS2, NOS3, NQO1, STAT3, XDH
dendrite 1 NQO1
phagocytic vesicle 1 ELANE
nucleoplasm 4 HPGDS, NOS2, NOS3, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 ACHE, LIPE, MGAM
Multi-pass membrane protein 1 HMGCR
Synapse 2 ACHE, NQO1
cell surface 4 ACHE, ADIPOQ, ELANE, VEGFA
Golgi apparatus 4 ACHE, FASN, NOS3, VEGFA
Golgi membrane 1 NOS3
neuromuscular junction 1 ACHE
neuronal cell body 1 NQO1
Cytoplasm, cytosol 3 LIPE, NOS2, NQO1
Lysosome 1 TYR
plasma membrane 8 ACHE, BCHE, FASN, IGHE, MGAM, NOS2, NOS3, STAT3
Membrane 7 ACHE, FASN, HMGCR, LIPE, MGAM, NQO1, VEGFA
apical plasma membrane 1 MGAM
caveola 2 LIPE, NOS3
extracellular exosome 3 ELANE, FASN, MGAM
endoplasmic reticulum 3 ADIPOQ, HMGCR, VEGFA
extracellular space 10 ACHE, ADIPOQ, BCHE, CCL2, ELANE, IGHE, IL4, LEP, VEGFA, XDH
perinuclear region of cytoplasm 4 ACHE, NOS2, NOS3, TYR
adherens junction 1 VEGFA
intracellular membrane-bounded organelle 2 HPGDS, TYR
Single-pass type I membrane protein 2 IGHE, TYR
Secreted 8 ACHE, ADIPOQ, BCHE, CCL2, IL4, LEP, MGAM, VEGFA
extracellular region 10 ACHE, ADIPOQ, BCHE, CCL2, ELANE, IGHE, IL4, LEP, MGAM, VEGFA
Single-pass membrane protein 1 MGAM
Extracellular side 1 ACHE
transcription regulator complex 1 STAT3
Secreted, extracellular space, extracellular matrix 1 VEGFA
Melanosome membrane 1 TYR
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Golgi-associated vesicle 1 TYR
Cytoplasm, perinuclear region 1 NOS2
extracellular matrix 1 VEGFA
Peroxisome 2 NOS2, XDH
basement membrane 1 ACHE
collagen trimer 1 ADIPOQ
sarcoplasmic reticulum 1 XDH
peroxisomal matrix 1 NOS2
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 2 ADIPOQ, ELANE
secretory granule 2 ELANE, VEGFA
chromatin 1 STAT3
IgE immunoglobulin complex 1 IGHE
cytoskeleton 1 NOS3
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 MGAM
Melanosome 2 FASN, TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
side of membrane 1 ACHE
Peroxisome membrane 1 HMGCR
endoplasmic reticulum lumen 1 BCHE
transcription repressor complex 1 ELANE
platelet alpha granule lumen 1 VEGFA
specific granule lumen 1 ELANE
endocytic vesicle membrane 1 NOS3
azurophil granule lumen 1 ELANE
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 MGAM
Cytoplasmic vesicle, phagosome 1 ELANE
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
cortical cytoskeleton 1 NOS2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
glycogen granule 1 FASN


文献列表

  • Yujuan Yu, Fumao Zeng, Peiheng Han, Li Zhang, Ling Yang, Feng Zhou, Qing Liu, Zheng Ruan. Dietary chlorogenic acid alleviates high-fat diet-induced steatotic liver disease by regulating metabolites and gut microbiota. International journal of food sciences and nutrition. 2024 Jun; 75(4):369-384. doi: 10.1080/09637486.2024.2318590. [PMID: 38389248]
  • Ngoc Phuc Nguyen, Quoc Giang Le, Vinh Nghi Truong, Thi Ngoc Dung Nguyen, Nguyen Truong Thang Phan, Manh Hung Tran. In vitro inhibition of 5-α reductase and in vivo suppression of benign prostatic hyperplasia by Physalis angulata ethyl acetate extract. Fitoterapia. 2024 Jun; 175(?):105950. doi: 10.1016/j.fitote.2024.105950. [PMID: 38599338]
  • Yongwang Yan, Qing Li, Fengluan Yang, Ling Shen, Kangxiao Guo, Xu Zhou. Chlorogenic acid ameliorates intestinal inflammation via miRNA-microbe axis in db/db mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024 May; 38(10):e23665. doi: 10.1096/fj.202400382r. [PMID: 38780085]
  • Ze Yun, Jiahao Li, Wenyue Zhu, Xin Yuan, Jiajia Zhao, Minjie Liao, Lingjun Ma, Fang Chen, Xiaosong Hu, Junfu Ji. Effects of Chlorogenic Acid on Lowering IgE-Binding Capacity of Soybean 7S: Comparison between Covalent and Noncovalent Interaction. Journal of agricultural and food chemistry. 2024 May; 72(21):12270-12280. doi: 10.1021/acs.jafc.4c01982. [PMID: 38743450]
  • Xixi Zeng, Ling Chen, Bo Zheng. Extrusion and chlorogenic acid treatment increase the ordered structure and resistant starch levels in rice starch with amelioration of gut lipid metabolism in obese rats. Food & function. 2024 May; 15(10):5224-5237. doi: 10.1039/d3fo05416k. [PMID: 38623646]
  • Ahmad Fauzi, Nurolaini Kifli, Mohd Hezmee Mohd Noor, Hazilawati Hamzah, Azrina Azlan. Bioactivity, phytochemistry studies and subacute in vivo toxicity of ethanolic leaf extract of white mulberry (Morus alba linn.) in female mice. Journal of ethnopharmacology. 2024 May; 325(?):117914. doi: 10.1016/j.jep.2024.117914. [PMID: 38360381]
  • Xin Wang, Xianyun Gong, Binbin Lin. Optimization of ultrasonic pretreatment and analysis of chlorogenic acid in potato leaves. Scientific reports. 2024 05; 14(1):10613. doi: 10.1038/s41598-024-61139-7. [PMID: 38719831]
  • Junru Wang, Min Wang, Chengfeng Zhang, Wenhui Li, Tianyu Zhang, Yanv Zhou, Matthew Flavel, Yu Xi, He Li, Xinqi Liu. Protective effects of sugarcane polyphenol against UV-B-induced photoaging in Balb/c mouse skin: Antioxidant, anti-inflammatory, and anti-glycosylation Effects. Journal of food science. 2024 May; 89(5):3048-3063. doi: 10.1111/1750-3841.17045. [PMID: 38563092]
  • Xiaoling Huang, Yi Li, Chun Cui, Dongxiao Sun-Waterhouse. Structural, functional properties, and in vitro digestibility of sunflower protein concentrate as affected by extraction method: Isoelectric precipitation vs ultrafiltration. Food chemistry. 2024 May; 439(?):138090. doi: 10.1016/j.foodchem.2023.138090. [PMID: 38043280]
  • Qingqing Luo, Peitao Chen, Jikai Zong, Jilong Gao, Ruihua Qin, Chunli Wu, Qina Lv, Yuanjiang Xu, Tengfei Zhao, Yufan Fu. Integrated transcriptomic and CGAs analysis revealed IbGLK1 is a key transcription factor for chlorogenic acid accumulation in sweetpotato (Ipomoea batatas [L.] Lam.) blades. International journal of biological macromolecules. 2024 May; 266(Pt 1):131045. doi: 10.1016/j.ijbiomac.2024.131045. [PMID: 38547942]
  • Vincenzo Piccolo, Maria Maisto, Elisabetta Schiano, Fortuna Iannuzzo, Niloufar Keivani, Maria Manuela Rigano, Antonello Santini, Ettore Novellino, Gian Carlo Tenore, Vincenzo Summa. Phytochemical investigation and antioxidant properties of unripe tomato cultivars (Solanum lycopersicum L.). Food chemistry. 2024 Apr; 438(?):137863. doi: 10.1016/j.foodchem.2023.137863. [PMID: 37980871]
  • Menglin Han, Chaonan Sun, Ying Bu, Wenhui Zhu, Xuepeng Li, Yi Zhang, Jianrong Li. Exploring the interaction mechanism of chlorogenic acid and myoglobin: Insights from structure and molecular dynamics simulation. Food chemistry. 2024 Apr; 438(?):138053. doi: 10.1016/j.foodchem.2023.138053. [PMID: 38007953]
  • Agnieszka Zielińska, Dorota Bryk, Katarzyna Paradowska, Paweł Siudem, Iwona Wawer, Małgorzata Wrzosek. Anti-Atherosclerotic Properties of Aronia melanocarpa Extracts Influenced by Their Chemical Composition Associated with the Ripening Stage of the Berries. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084145. [PMID: 38673738]
  • Wenjuan Ma, Jianglan Long, Linjie Dong, Jian Zhang, Aiting Wang, Yu Zhang, Dan Yan. Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation. Journal of ethnopharmacology. 2024 Apr; 323(?):117752. doi: 10.1016/j.jep.2024.117752. [PMID: 38216099]
  • Jiaheng Li, Wenjun Wang, Weidong Xu, Yong Deng, Ruiling Lv, Jianwei Zhou, Donghong Liu. Evaluation of multiscale mechanisms of ultrasound-assisted extraction from porous plant materials: Experiment and modeling on this intensified process. Food research international (Ottawa, Ont.). 2024 Apr; 182(?):114034. doi: 10.1016/j.foodres.2024.114034. [PMID: 38519197]
  • Ming-Chang Tsai, Chi-Chih Wang, I-Ning Tsai, Meng-Hsun Yu, Mon-Yuan Yang, Yi-Ju Lee, Kuei-Chuan Chan, Chau-Jong Wang. Improving the Effects of Mulberry Leaves and Neochlorogenic Acid on Glucotoxicity-Induced Hepatic Steatosis in High Fat Diet Treated db/db Mice. Journal of agricultural and food chemistry. 2024 Mar; 72(12):6339-6346. doi: 10.1021/acs.jafc.3c09033. [PMID: 38488910]
  • Hanjiao He, Qing Wei, Jiao Chang, Xu Yi, Xiang Yu, Guoyong Luo, Xinfeng Li, Wude Yang, Yi Long. Exploring the hypoglycemic mechanism of chlorogenic acids from Pyrrosia petiolosa (Christ) Ching on type 2 diabetes mellitus based on network pharmacology and transcriptomics strategy. Journal of ethnopharmacology. 2024 Mar; 322(?):117580. doi: 10.1016/j.jep.2023.117580. [PMID: 38104881]
  • Ju-Bin Kang, Hyun-Kyoung Son, Dong-Ju Park, Yeung-Bae Jin, Fawad-Ali Shah, Phil-Ok Koh. Modulation of thioredoxin by chlorogenic acid in an ischemic stroke model and glutamate-exposed neurons. Neuroscience letters. 2024 Mar; 825(?):137701. doi: 10.1016/j.neulet.2024.137701. [PMID: 38395190]
  • Chien-Yi Ho, Chih-Hsin Tang, Trung-Loc Ho, Wen-Ling Wang, Chun-Hsu Yao. Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation. Aging. 2024 Mar; 16(5):4832-4840. doi: 10.18632/aging.205635. [PMID: 38461437]
  • Kai Zhang, Hongling Meng, Mengmeng Du, Yifan Du, Xuemin Li, Yang Wang, Huawei Liu. Quantitative Phosphoproteomics Analysis Reveals the Protective Mechanism of Chlorogenic Acid on Immunologically Stressed Broiler Meat Quality. Journal of agricultural and food chemistry. 2024 Mar; 72(9):5062-5072. doi: 10.1021/acs.jafc.3c07304. [PMID: 38377574]
  • Fevzi Elbasan, Busra Arikan, Ceyda Ozfidan-Konakci, Aysenur Tofan, Evren Yildiztugay. Hesperidin and chlorogenic acid mitigate arsenic-induced oxidative stress via redox regulation, photosystems-related gene expression, and antioxidant efficiency in the chloroplasts of Zea mays. Plant physiology and biochemistry : PPB. 2024 Mar; 208(?):108445. doi: 10.1016/j.plaphy.2024.108445. [PMID: 38402801]
  • Chaohui Dai, Hui Li, Weimin Zhao, Yanfeng Fu, Jinhua Cheng. Bioactive functions of chlorogenic acid and its research progress in pig industry. Journal of animal physiology and animal nutrition. 2024 Mar; 108(2):439-450. doi: 10.1111/jpn.13905. [PMID: 37975278]
  • Gloria Yareli Gutierrez-Silerio, Pablo Garcia-Solis, Elhadi M Yahia, José David Núñez-Ríos, Francisco Vázquez-Cuevas, Pablo Alan Rodriguez-Salinas, Rolando Mendoza-Zuñiga, Aaron Kuri-García. Cytotoxic and Antitumoral Effects of Methanolic Extracts of Avocado Fruit Mesocarp in Colorectal Cancer Cell Line HT29. Journal of medicinal food. 2024 Mar; 27(3):211-221. doi: 10.1089/jmf.2023.0112. [PMID: 38407926]
  • Jimena Del P Cejas, Antonio S Rosa, Agustín N González Paz, Edgardo A Disalvo, María de Los A Frías. Impact of chlorogenic acid on surface and phase properties of cholesterol-enriched phosphatidylcholine membranes. Archives of biochemistry and biophysics. 2024 Mar; 753(?):109913. doi: 10.1016/j.abb.2024.109913. [PMID: 38286353]
  • Zebo Liu, Xiaofeng Zhu, Ali Mohsin, Huijie Sun, Linxiao Du, Zhongping Yin, Yingping Zhuang, Meijin Guo. Uncovering the Role of Hydroxycinnamoyl Transferase in Boosting Chlorogenic Acid Accumulation in Carthamus tinctorius Cells under Methyl Jasmonate Elicitation. International journal of molecular sciences. 2024 Feb; 25(5):. doi: 10.3390/ijms25052710. [PMID: 38473957]
  • Érica Mendes Dos Santos, Lucas Malvezzi de Macedo, Janaína Artem Ataide, Jeany Delafiori, João Paulo de Oliveira Guarnieri, Paulo César Pires Rosa, Ana Lucia Tasca Gois Ruiz, Marcelo Lancellotti, Angela Faustino Jozala, Rodrigo Ramos Catharino, Gisele Anne Camargo, Ana Cláudia Paiva-Santos, Priscila Gava Mazzola. Antioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmetic. Scientific reports. 2024 02; 14(1):4453. doi: 10.1038/s41598-024-54797-0. [PMID: 38396007]
  • Vivek Kumar Awon, Debabrata Dutta, Saptadipa Banerjee, Soumili Pal, Gaurab Gangopadhyay. Integrated metabolomics and transcriptomics analysis highlight key pathways involved in the somatic embryogenesis of Darjeeling tea. BMC genomics. 2024 Feb; 25(1):207. doi: 10.1186/s12864-024-10119-2. [PMID: 38395740]
  • Taian Yi, Jiesi Luo, Ruixue Liao, Long Wang, Anguo Wu, Yueyue Li, Ling Zhou, Chengyang Ni, Kai Wang, Xiaoqin Tang, Wenjun Zou, Jianming Wu. An Innovative Inducer of Platelet Production, Isochlorogenic Acid A, Is Uncovered through the Application of Deep Neural Networks. Biomolecules. 2024 Feb; 14(3):. doi: 10.3390/biom14030267. [PMID: 38540688]
  • Rei Uranishi, Raju Aedla, Doaa H M Alsaadi, Dongxing Wang, Ken Kusakari, Hirotaka Osaki, Koji Sugimura, Takashi Watanabe. Evaluation of Environmental Factor Effects on the Polyphenol and Flavonoid Content in the Leaves of Chrysanthemum indicum L. and Its Habitat Suitability Prediction Mapping. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050927. [PMID: 38474439]
  • Wen Zhang, Qian-Yu Zhang, Ji Li, Xue-Ning Ren, Yue Zhang, Qiao Niu. Study on the Digestive Behavior of Chlorogenic Acid in Biomimetic Dietary Fiber and the Antioxidative Synergistic Effect of Polysaccharides and Chlorogenic Acid. Journal of agricultural and food chemistry. 2024 Feb; 72(5):2634-2647. doi: 10.1021/acs.jafc.3c08886. [PMID: 38267223]
  • Kai He, Xiaoying Wang, Tingting Li, Yanfei Li, Linlin Ma. Chlorogenic Acid Attenuates Isoproterenol Hydrochloride-Induced Cardiac Hypertrophy in AC16 Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040760. [PMID: 38398512]
  • Yunhui Liao, Feng Chen, Haishan Tang, Wubliker Dessie, Zuodong Qin. Combination of a Deep Eutectic Solvent and Macroporous Resin for Green Recovery of Iridoids, Chlorogenic Acid, and Flavonoids from Eucommia ulmoides Leaves. Molecules (Basel, Switzerland). 2024 Feb; 29(3):. doi: 10.3390/molecules29030737. [PMID: 38338480]
  • Zidan Luo, Mengfei Tian, Naveed Ahmad, Yuxin Xie, Chunguo Xu, Jie Liu, Chunjian Zhao, Chunying Li. A surface multiple imprinting layers membrane with well-oriented recognition sites for selective separation of chlorogenic acid from Ficus carica L. Food chemistry. 2024 Feb; 433(?):137347. doi: 10.1016/j.foodchem.2023.137347. [PMID: 37683463]
  • Fábio Florença Cardoso, Guilherme Henrique Marchi Salvador, Walter Luís Garrido Cavalcante, Maeli Dal-Pai, Marcos Roberto de Mattos Fontes. BthTX-I, a phospholipase A2-like toxin, is inhibited by the plant cinnamic acid derivative: chlorogenic acid. Biochimica et biophysica acta. Proteins and proteomics. 2024 02; 1872(2):140988. doi: 10.1016/j.bbapap.2023.140988. [PMID: 38142025]
  • Xin Liu, Xiao-Ying He, Bo-Long Liu, Ping-Shun Song. [Determination of 13 chemical components of Epimedii Folium in pharmacopoeia by UPLC method combined with quantitative analysis of multicomponents by single-marker]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):981-988. doi: 10.19540/j.cnki.cjcmm.20231115.103. [PMID: 38621905]
  • Tuğba Günbatan, Melike Sucu, Alper Gokbulut, Elif Dilmaç, İlhan Gürbüz. Chymotrypsin and Trypsin Inhibitory Activity of Some Medicinal Plants Collected from Rize (Türkiye). Chemistry & biodiversity. 2024 Jan; ?(?):e202301879. doi: 10.1002/cbdv.202301879. [PMID: 38288857]
  • Antonio D'Errico, Rosarita Nasso, Antimo Di Maro, Nicola Landi, Angela Chambery, Rosita Russo, Stefania D'Angelo, Mariorosario Masullo, Rosaria Arcone. Identification and Characterization of Neuroprotective Properties of Thaumatin-like Protein 1a from Annurca Apple Flesh Polyphenol Extract. Nutrients. 2024 Jan; 16(2):. doi: 10.3390/nu16020307. [PMID: 38276545]
  • Chunxiu Lu, Liang Jin, Huifen Zhou, Jiehong Yang, Haitong Wan. Chlorogenic acid inhibits macrophage PANoptosis induced by cefotaxime-resistant Escherichia coli. Archives of microbiology. 2024 Jan; 206(2):67. doi: 10.1007/s00203-023-03777-5. [PMID: 38236396]
  • Narsingh Verma, Madhukar Mittal, Abbas Ali Mahdi, Vandana Awasthi, Pawan Kumar, Apurva Goel, Samudra P Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Debasis Bagchi. Clinical Evaluation of a Novel, Patented Green Coffee Bean Extract (GCB70®), Enriched in 70\% Chlorogenic Acid, in Overweight Individuals. Journal of the American Nutrition Association. 2024 Jan; ?(?):1-11. doi: 10.1080/27697061.2023.2284994. [PMID: 38227783]
  • Han Ding, Kunyi Ge, Changyu Fan, Dandan Liu, Chenyu Wu, Rongpeng Li, Feng-Juan Yan. Chlorogenic Acid Attenuates Hepatic Steatosis by Suppressing ZFP30. Journal of agricultural and food chemistry. 2024 Jan; 72(1):245-258. doi: 10.1021/acs.jafc.3c02988. [PMID: 38148374]
  • Xinhe Wang, Jiarui Zhao, Zhi Lin, Jun Li, Xiaowen Li, Xinyi Xu, Yuchen Wang, Guangfu Lv, He Lin, Zhe Lin. Analysis of Polyphenol Extract from Hazel Leaf and Ameliorative Efficacy and Mechanism against Hyperuricemia Zebrafish Model via Network Pharmacology and Molecular Docking. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020317. [PMID: 38257230]
  • Muhammad Fakhar-E-Alam Kulyar, Quan Mo, Wangyuan Yao, Yan Li, Shah Nawaz, Kyein San Loon, Ahmed Ezzat Ahmed, Aiman A Alsaegh, Khalid M Al Syaad, Muhammad Akhtar, Zeeshan Ahmad Bhutta, Jiakui Li, Desheng Qi. Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid. Cell communication and signaling : CCS. 2024 01; 22(1):2. doi: 10.1186/s12964-023-01377-w. [PMID: 38169388]
  • Chao Meng, Lingye Zhou, Lin Huang, Qi Gu, Xinyue Du, Cheng Wang, Fanglan Liu, Chunhua Xia. Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155271. doi: 10.1016/j.phymed.2023.155271. [PMID: 38103317]
  • Rui Li, Yun Zhan, Xiao Ding, Jinjin Cui, Yanxing Han, Jinlan Zhang, Jie Zhang, Wenbin Li, Lulu Wang, Jiandong Jiang. Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody. International journal of biological sciences. 2024; 20(1):61-77. doi: 10.7150/ijbs.83599. [PMID: 38164171]
  • Nilofar, Tugce Duran, Abdullahi Ibrahim Uba, Aleksandra Cvetanović Kljakić, Jelena Božunović, Uroš Gašić, Abdelhakim Bouyahya, Evren Yıldiztugay, Claudio Ferrante, Gokhan Zengin. Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti-cancer effects. Journal of separation science. 2024 Jan; 47(1):e2300678. doi: 10.1002/jssc.202300678. [PMID: 37994215]
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