Oleanolic acid (BioDeep_00000000554)

 

Secondary id: BioDeep_00000398505, BioDeep_00000859512

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Antitumor activity natural product


代谢物信息卡片


(4aS,5S,6aS,6bR,8R,8aR,10S,12aR,12bR,14bS)-10-Hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid

化学式: C30H48O3 (456.3603)
中文名称: 丁香油素, 土当归酸, 石竹素, 齐墩果酸
谱图信息: 最多检出来源 Homo sapiens(feces) 18.98%

分子结构信息

SMILES: C1[C@@H](C([C@@H]2[C@](C1)([C@H]1[C@@](CC2)([C@]2(C(=CC1)[C@@H]1[C@@](CC2)(CCC(C1)(C)C)C(=O)O)C)C)C)(C)C)O
InChI: InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)

描述信息

Oleanolic acid is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil (Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption). Pentacyclic triterpenes are natural compounds which are widely distributed in plants. These natural products have been demonstrated to possess anti-inflammatory properties. Triterpenoids have been reported to possess antioxidant properties, since they prevent lipid peroxidation and suppress superoxide anion generation. The triterpenes have a history of medicinal use in many Asian countries. Oleanolic acid exhibits both pro- and anti-inflammatory properties depending on chemical structure and dose and may be useful in modulating the immune response; further studies are required to confirm the immunomodulatory behaviour of this triterpenoid, and characterise the mechanisms underlying the biphasic nature of some aspects of the inflammatory response. Oleanolic acid is a ubiquitous triterpenoid in plant kingdom, medicinal herbs, and is an integral part of the human diet. During the last decade over 700 research articles have been published on triterpenoids research, reflecting tremendous interest and progress in our understanding of these compounds. This included the isolation and purification of these tritepernoids from various plants and herbs, the chemical modifications to make more effective and water soluble derivatives, the pharmacological research on their beneficial effects, the toxicity studies, and the clinical use of these triterpenoids in various diseases including anticancer chemotherapies. (PMID:17292619, 15522132, 15994040).
Oleanolic acid is a pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3. It has a role as a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It is a conjugate acid of an oleanolate. It derives from a hydride of an oleanane.
Oleanolic acid is a natural product found in Ophiopogon japonicus, Freziera, and other organisms with data available.
A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.
See also: Holy basil leaf (part of); Jujube fruit (part of); Paeonia lactiflora root (part of) ... View More ...
Occurs as glycosides in cloves (Syzygium aromaticum), sugar beet (Beta vulgaris), olive leaves, etc. Very widely distributed aglycone
A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
[Raw Data] CBA90_Oleanolic-acid_neg_50eV.txt
[Raw Data] CBA90_Oleanolic-acid_neg_20eV.txt
[Raw Data] CBA90_Oleanolic-acid_neg_10eV.txt
[Raw Data] CBA90_Oleanolic-acid_neg_30eV.txt
[Raw Data] CBA90_Oleanolic-acid_neg_40eV.txt
Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.
Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.

同义名列表

92 个代谢物同义名

(4aS,5S,6aS,6bR,8R,8aR,10S,12aR,12bR,14bS)-10-Hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid; (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid; (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylicacid; (2S,5S,10S,18S,1R,14R,15R,20R)-18-hydroxy-1,2,8,8,15,19,19-heptamethylpentacyc lo[12.8.0.0<2,11>.0<5,10>.0<15,20>]docos-11-ene-5-carboxylic acid; Oleanolic acid, United States Pharmacopeia (USP) Reference Standard; Oleanolic acid, European Pharmacopoeia (EP) Reference Standard; Oleanolic acid, primary pharmaceutical reference standard; OLEANOLIC ACID (CONSTITUENT OF HOLY BASIL LEAF) [DSC]; OLEANOLIC ACID (CONSTITUENT OF BANABA LEAF) [DSC]; (3.beta.)-3-beta-hydroxy-Olean-12-en-28-oic acid; Olean-12-en-28-oic acid, 3-hydroxy-, (3.beta.)-; OLEANOLIC ACID (CONSTITUENT OF HOLY BASIL LEAF); Olean-12-en-28-oic acid, 3-hydroxy-, (3-beta)-; Olean-12-en-28-oic acid, 3-hydroxy-, (3beta)-; (3.beta.)-3-beta-hydroxy-Olean-12-en-28-oate; OLEANOLIC ACID (CONSTITUENT OF BANABA LEAF); (3.beta.)-3-hydroxy-Olean-12-en-28-oic acid; (3.beta.)-3-Hydroxyolean-12-en-28-oic acid; Olean-12-en-28-oic acid, 3-hydroxy-, (3b)-; Olean-12-en-28-oic acid, 3.beta.-hydroxy-; (3-beta)-3-Hydroxyolean-12-en-28-oic acid; (3beta)-3-hydroxyolean-12-en-28-oic acid; Olean-12-en-28-oic acid, 3-beta-hydroxy-; (3.beta.)-3-hydroxy-Olean-12-en-28-oate; Olean-12-en-28-oic acid, 3beta-hydroxy-; 3.beta.-hydroxy-Olean-12-en-28-oic acid; 3.BETA.-HYDROXYOLEAN-12-EN-28-OIC ACID; 3beta-hydroxy-Olean-12-en-28-oic acid; (3?)-3-Hydroxyolean-12-en-28-oic acid; (3β)-3-Hydroxyolean-12-en-28-oic acid; (3-beta)-3-Hydroxyolean-12-en-28-oate; 3-beta-Hydroxyolean-12-en-28-oic acid; 3beta-Hydroxyolean-12-en-28-oic acid; C7EE6ACC-7175-4947-B524-FF8479525DA1; Oleanolic acid, analytical standard; 3.beta.-hydroxy-Olean-12-en-28-oate; 3-beta-Hydroxyolean-12-en-28-oate; 3beta-hydroxy-Olean-12-en-28-oate; 3Β-hydroxyolean-12-en-28-Oic acid; 3b-Hydroxyolean-12-en-28-Oic acid; 3beta-Hydroxyolean-12-en-28-Oate; Oleanolic acid (OA)(Compound 1); 3b-Hydroxyolean-12-en-28-Oate; 3Β-hydroxyolean-12-en-28-Oate; MIJYXULNPSFWEK-GTOFXWBISA-N; OLEANOLIC ACID [USP-RS]; OLEANOLIC ACID [WHO-DD]; OLEANOLIC ACID (USP-RS); Oleanolic acid, >=97\\%; OLEANOLIC ACID [INCI]; Oleanoic Acid Hydrate; Triterpenes, Oleanane; OleanolsA currencyure; Oleanane Triterpenes; OLEANOLIC ACID [MI]; (+)-Oleanolic acid; Giganteumgenin C; Virgaureagenin B; Astrantiagenin C; UNII-6SMK8R7TGJ; oleonolic acid; Oleanolic Acid; OLEANOLIC_ACID; oleanolic-acid; OleanolicAcid; Gledigenin 1; Caryophyllin; Oleanic acid; Oleanolate; 6SMK8R7TGJ; Oleanate; Hederins; Oleanol; OA; (3.β.)-3-β-hydroxy-Olean-12-en-28-oic acid; (3.β.)-3-beta-hydroxy-Olean-12-en-28-oate; (3.β.)-3-hydroxy-Olean-12-en-28-oic acid; (3-β)-3-Hydroxyolean-12-en-28-oic acid; 3.β.-hydroxy-Olean-12-en-28-oic acid; (3.β.)-3-hydroxy-Olean-12-en-28-oate; (3-β)-3-Hydroxyolean-12-en-28-oate; 3-β-Hydroxyolean-12-en-28-oic acid; 3β-hydroxy-Olean-12-en-28-oic acid; 3β-Hydroxyolean-12-en-28-oic acid; 3.β.-hydroxy-Olean-12-en-28-oate; 3-β-Hydroxyolean-12-en-28-oate; 3β-hydroxy-Olean-12-en-28-oate; 3β-Hydroxyolean-12-en-28-oate; 3-Hydroxyolean-12-en-28-oic acid; Oleanolic acid



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2975 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AKT1, ANG, ANXA5, BCL2, CASP3, CASP8, HMGB1, MAPK14, MTOR, PPARG, PTGS2, STAT3, SYT1, TP53, VEGFA
Peripheral membrane protein 5 ANXA5, CYP1B1, HMGB1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, MTOR, PTGS2
Nucleus 13 AKT1, ANG, BCL2, CASP3, CASP8, FOS, HMGB1, MAPK14, MTOR, PPARG, STAT3, TP53, VEGFA
cytosol 12 AKT1, ANG, ANXA5, BCL2, CASP3, CASP8, FOS, MAPK14, MTOR, PPARG, STAT3, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 TP53
nucleoplasm 10 AKT1, CASP3, CASP8, FOS, HMGB1, MAPK14, MTOR, PPARG, STAT3, TP53
RNA polymerase II transcription regulator complex 3 FOS, PPARG, STAT3
Cell membrane 2 AKT1, HMGB1
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, CASP8
Golgi apparatus membrane 1 MTOR
Synapse 1 SYT1
cell cortex 1 AKT1
cell surface 2 HMGB1, VEGFA
glutamatergic synapse 4 AKT1, CASP3, MAPK14, SYT1
Golgi apparatus 2 SYT1, VEGFA
Golgi membrane 2 INS, MTOR
growth cone 1 ANG
lysosomal membrane 2 GAA, MTOR
neuronal cell body 2 ANG, CASP3
postsynapse 1 AKT1
presynaptic membrane 1 SYT1
sarcolemma 1 ANXA5
synaptic vesicle 1 SYT1
Lysosome 2 GAA, MTOR
endosome 1 HMGB1
plasma membrane 5 AKT1, GAA, HMGB1, STAT3, SYT1
presynaptic active zone 1 SYT1
synaptic vesicle membrane 1 SYT1
Membrane 9 AKT1, ANXA5, BCL2, CYP1B1, GAA, MTOR, SYT1, TP53, VEGFA
axon 1 SYT1
caveola 1 PTGS2
extracellular exosome 2 ANXA5, GAA
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 6 BCL2, FOS, HMGB1, PTGS2, TP53, VEGFA
extracellular space 5 ANG, HMGB1, IL17A, INS, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 PPARG
adherens junction 1 VEGFA
mitochondrion 5 BCL2, CASP8, CYP1B1, MAPK14, TP53
protein-containing complex 5 AKT1, BCL2, CASP8, PTGS2, TP53
intracellular membrane-bounded organelle 3 CYP1B1, GAA, PPARG
Microsome membrane 3 CYP1B1, MTOR, PTGS2
postsynaptic density 2 CASP3, SYT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 6 ANG, GAA, HMGB1, IL17A, INS, VEGFA
extracellular region 8 ANG, ANXA5, GAA, HMGB1, IL17A, INS, MAPK14, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 BCL2, SYT1
mitochondrial outer membrane 3 BCL2, CASP8, MTOR
excitatory synapse 1 SYT1
hippocampal mossy fiber to CA3 synapse 1 SYT1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 HMGB1
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SYT1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, IL17A
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 AKT1
nucleolus 2 ANG, TP53
cell-cell junction 1 AKT1
vesicle 1 AKT1
postsynaptic membrane 1 SYT1
Cell projection, lamellipodium 1 CASP8
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
spindle 1 AKT1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
Zymogen granule membrane 1 ANXA5
neuron projection 2 PTGS2, SYT1
ciliary basal body 1 AKT1
chromatin 4 FOS, PPARG, STAT3, TP53
Chromosome 2 ANG, HMGB1
cytoskeleton 1 CASP8
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, SYT1
endosome lumen 1 INS
tertiary granule membrane 1 GAA
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
exocytic vesicle 1 SYT1
ficolin-1-rich granule lumen 2 HMGB1, MAPK14
secretory granule lumen 3 HMGB1, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
nuclear matrix 2 FOS, TP53
transcription repressor complex 2 HMGB1, TP53
platelet alpha granule lumen 1 VEGFA
dense core granule 1 SYT1
endocytic vesicle 1 ANG
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 SYT1
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 FOS
ficolin-1-rich granule membrane 1 GAA
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
Cytoplasmic vesicle, secretory vesicle membrane 1 SYT1
condensed chromosome 1 HMGB1
postsynaptic cytosol 1 SYT1
Cytoplasmic vesicle, phagosome 1 MTOR
presynaptic cytosol 1 SYT1
transcription factor AP-1 complex 1 FOS
angiogenin-PRI complex 1 ANG
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
neuron projection terminus 1 SYT1
endothelial microparticle 1 ANXA5
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 SYT1
chromaffin granule membrane 1 SYT1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1 SYT1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
clathrin-sculpted acetylcholine transport vesicle membrane 1 SYT1
clathrin-sculpted glutamate transport vesicle membrane 1 SYT1
clathrin-sculpted monoamine transport vesicle membrane 1 SYT1


文献列表

  • Daniel Mejía-Valdez, Marilena Antunes-Ricardo, Mariana Martínez-Ávila, Daniel Guajardo-Flores. Enhancement of oleanolic acid concentration through acid hydrolysis of saponin-rich extracts from Chenopodium berlandieri. Food chemistry. 2024 Aug; 449(?):139254. doi: 10.1016/j.foodchem.2024.139254. [PMID: 38583403]
  • Shivani Puri, Prithvi Pal Singh, Prateek Singh Bora, Upendra Sharma. Chemometric guided isolation of new triterpenoid saponins as acetylcholinesterase inhibitors from seeds of Achyranthes bidentata Blume. Fitoterapia. 2024 Jun; 175(?):105925. doi: 10.1016/j.fitote.2024.105925. [PMID: 38537885]
  • Rui Zhang, Xiangchuan Li, Jixu Qu, Doudou Zhang, Linxu Cao, Xuemei Qin, Zhenyu Li. Intercropping with maize and sorghum-induced saikosaponin accumulation in Bupleurum chinense DC. by liquid chromatography-mass spectrometry-based metabolomics. Journal of mass spectrometry : JMS. 2024 Jun; 59(6):e5035. doi: 10.1002/jms.5035. [PMID: 38726730]
  • Junfeng Tan, Zengguang Zhang, Dan Zheng, Yu Mu, Bixuan Cao, Junwei Yang, Li Han, Xueshi Huang. Structure-activity relationship and biofilm formation-related gene targets of oleanolic acid-type saponins from Pulsatilla chinensis against Candida albicans. Bioorganic chemistry. 2024 May; 146(?):107311. doi: 10.1016/j.bioorg.2024.107311. [PMID: 38547720]
  • Meng Gao, Qing Cai, Yehua Bian, Zhuoya Wang, Lina Xu, Jinyong Peng. Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116529. doi: 10.1016/j.biopha.2024.116529. [PMID: 38569275]
  • Mei Tong He, Geonha Park, Do Hwi Park, Minsik Choi, Sejin Ku, Seung Hyeon Go, Yun Gyo Lee, Seok Jun Song, Chang-Wook Ahn, Young Pyo Jang, Ki Sung Kang. So Shiho Tang Reduces Inflammation in Lipopolysaccharide-Induced RAW 264.7 Macrophages and Dextran Sodium Sulfate-Induced Colitis Mice. Biomolecules. 2024 Apr; 14(4):. doi: 10.3390/biom14040451. [PMID: 38672468]
  • Han Yu, Jun Zhou, Jing Zhang, Xinyi He, Siqing Peng, Hao Ling, Zhuang Dong, Xiangyang Lu, Yun Tian, Guiping Guan, Qi Tang, Xiaohong Zhong, Yuedong He. Functional Identification of HhUGT74AG11-A Key Glycosyltransferase Involved in Biosynthesis of Oleanane-Type Saponins in Hedera helix. International journal of molecular sciences. 2024 Apr; 25(7):. doi: 10.3390/ijms25074067. [PMID: 38612877]
  • Zongzhan Wu, Wenyu Dou, Xiaolin Yang, Tengfei Niu, Zhuzhen Han, Li Yang, Rufeng Wang, Zhengtao Wang. Novel glycosidase from Paenibacillus lactis 154 hydrolyzing the 28-O-β-D-glucopyranosyl ester bond of oleanane-type saponins. Applied microbiology and biotechnology. 2024 Apr; 108(1):282. doi: 10.1007/s00253-024-13109-2. [PMID: 38573330]
  • Manh Khoa Nguyen, Viet Phong Nguyen, Seo Young Yang, Byung Sun Min, Jeong Ah Kim. Astraoleanosides E-P, oleanane-type triterpenoid saponins from the aerial parts of Astragalus membranaceus Bunge and their β-glucuronidase inhibitory activity. Bioorganic chemistry. 2024 Apr; 145(?):107230. doi: 10.1016/j.bioorg.2024.107230. [PMID: 38387397]
  • Kun Yang, Sheng-Bing Wang, Dong Pei, Lu-Mei Pu, Xin-Yi Huang. Effective separation of maslinic acid and oleanolic acid from olive pomace using high-speed shear off-line coupled with high-speed countercurrent chromatography and their antibacterial activity test. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Apr; 1236(?):124069. doi: 10.1016/j.jchromb.2024.124069. [PMID: 38442634]
  • Xiwu Rao, Ziwen Li, Qinchang Zhang, Yueyang Lai, Jianrong Liu, Liu Li, Haibo Cheng, Weixing Shen, Dongdong Sun. α-Hederin induces paraptosis by targeting GPCRs to activate Ca2+/MAPK signaling pathway in colorectal cancer. Cancer medicine. 2024 Apr; 13(8):e7202. doi: 10.1002/cam4.7202. [PMID: 38659391]
  • Wentao Jia, Shufang Liang, Mingming Jin, Shu Li, Jiaying Yuan, Jinbo Zhang, Wanfu Lin, Yuqian Wang, Shuchang Nie, Changquan Ling, Binbin Cheng. Oleanolic acid inhibits hypoxic tumor-derived exosomes-induced premetastatic niche formation in hepatocellular carcinoma by targeting ERK1/2-NFκB signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155208. doi: 10.1016/j.phymed.2023.155208. [PMID: 38387275]
  • Yinting Chen, Christine Lafleur, Ryan J Smith, Diljot Kaur, Brian T Driscoll, Jacqueline C Bede. Trichoplusia ni Transcriptomic Responses to the Phytosaponin Aglycone Hederagenin: Sex-Related Differences. Journal of chemical ecology. 2024 Apr; 50(3-4):168-184. doi: 10.1007/s10886-024-01482-1. [PMID: 38443712]
  • Tong Niu, Jinqian Yu, Zhenqiang Wang, Chuangchuang Wang, Yingjian Guo, Jian Li, Xiao Wang. Purification of triterpenoid saponins and 25R/25S-inokosterone from Achyranthes bidentata Bl. by high-speed countercurrent chromatography coupled silver nitrate coordination. Journal of separation science. 2024 Apr; 47(7):e2300901. doi: 10.1002/jssc.202300901. [PMID: 38605456]
  • Mingxia Xie, Hongping Long, Sainan Tian, Zhengqing Zhu, Pan Meng, Ke Du, Yajing Wang, Dongwei Guo, Hanqing Wang, Qinghua Peng. Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination. International immunopharmacology. 2024 Mar; 130(?):111749. doi: 10.1016/j.intimp.2024.111749. [PMID: 38430804]
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