Protocatechuic acid (BioDeep_00000000138)

 

Secondary id: BioDeep_00000400089, BioDeep_00000859384

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs


代谢物信息卡片


3,4-dihydroxybenzoic acid

化学式: C7H6O4 (154.0266076)
中文名称: 原儿茶酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.72%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Protocatechuic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/protocatechuic_acid (retrieved 2024-09-18) (BioDeep RN: BioDeep_00000000138). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(c(cc(cc1)C(=O)O)O)O
InChI: InChI=1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)

描述信息

Protocatechuic acid, also known as protocatechuate or 3,4-dihydroxybenzoate, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. Hydroxybenzoic acid derivatives are compounds containing a hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxyl and a hydroxyl groups. The enzyme protocatechuate 3,4-dioxygenase uses 3,4-dihydroxybenzoate and O2 to produce 3-carboxy-cis,cis-muconate. Protocatechuic acid is a drug. In the analogous hardening of the cockroach ootheca, the phenolic substance concerned is protocatechuic acid. Protocatechuic acid is a mild, balsamic, and phenolic tasting compound. Outside of the human body, protocatechuic acid is found, on average, in the highest concentration in a few different foods, such as garden onions, cocoa powders, and star anises and in a lower concentration in lentils, liquors, and red raspberries. Protocatechuic acid has also been detected, but not quantified in several different foods, such as cloud ear fungus, american pokeweeds, common mushrooms, fruits, and feijoa. This could make protocatechuic acid a potential biomarker for the consumption of these foods. It is also found in Allium cepa (17,540 ppm). It is a major metabolite of antioxidant polyphenols found in green tea. Similarly, PCA was reported to increase proliferation and inhibit apoptosis of neural stem cells. In vitro testing documented antioxidant and anti-inflammatory activity of PCA, while liver protection in vivo was measured by chemical markers and histological assessment.
3,4-dihydroxybenzoic acid, also known as protocatechuic acid or 4-carboxy-1,2-dihydroxybenzene, belongs to hydroxybenzoic acid derivatives class of compounds. Those are compounds containing a hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxyl and a hydroxyl groups. 3,4-dihydroxybenzoic acid is soluble (in water) and a weakly acidic compound (based on its pKa). 3,4-dihydroxybenzoic acid can be synthesized from benzoic acid. 3,4-dihydroxybenzoic acid is also a parent compound for other transformation products, including but not limited to, methyl 3,4-dihydroxybenzoate, ethyl 3,4-dihydroxybenzoate, and 1-(3,4-dihydroxybenzoyl)-beta-D-glucopyranose. 3,4-dihydroxybenzoic acid is a mild, balsamic, and phenolic tasting compound and can be found in a number of food items such as white mustard, grape wine, abalone, and asian pear, which makes 3,4-dihydroxybenzoic acid a potential biomarker for the consumption of these food products. 3,4-dihydroxybenzoic acid can be found primarily in blood, feces, and urine, as well as in human fibroblasts and testes tissues. 3,4-dihydroxybenzoic acid exists in all eukaryotes, ranging from yeast to humans. Protocatechuic acid (PCA) is a dihydroxybenzoic acid, a type of phenolic acid. It is a major metabolite of antioxidant polyphenols found in green tea. It has mixed effects on normal and cancer cells in in vitro and in vivo studies .
3,4-dihydroxybenzoic acid is a dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4. It has a role as a human xenobiotic metabolite, a plant metabolite, an antineoplastic agent, an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor and an EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor. It is a member of catechols and a dihydroxybenzoic acid. It is functionally related to a benzoic acid. It is a conjugate acid of a 3,4-dihydroxybenzoate.
3,4-Dihydroxybenzoic acid is a natural product found in Visnea mocanera, Amomum subulatum, and other organisms with data available.
Protocatechuic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
See also: Black Cohosh (part of); Vaccinium myrtillus Leaf (part of); Menyanthes trifoliata leaf (part of) ... View More ...
A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.

Protocatechuic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=99-50-3 (retrieved 2024-06-29) (CAS RN: 99-50-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.
Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.

同义名列表

60 个代谢物同义名

Protocatechuic acid, United States Pharmacopeia (USP) Reference Standard; Protocatechuic acid, primary pharmaceutical reference standard; InChI=1/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11; 3,4-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 97\\%; PROTOCATECHOIC ACID (CONSTITUENT OF MARITIME PINE) [DSC]; PROTOCATECHOIC ACID (CONSTITUENT OF MARITIME PINE); 3,4-dihydroxybenzoate;3,4-Dihydroxybenzoic acid; 3,4-Dihydroxybenzoic acid, analytical standard; DROXIDOPA METABOLITE (PROTOCATECHOIC ACID); protocatechuic acid, carboxy-14C-labeled; 3,4-Dihydroxybenzoic acid, >=97.0\\% (T); 1,2-Dihydroxybenzene-4-carboxylic acid; protocatechuic acid, monosodium salt; 3,4-DIHYDROXYBENZOIC ACID [INCI]; Pyrocatechol-4-carboxylic Acid; 4-Carboxy-1,2-dihydroxybenzene; Benzoic acid, 3,4-dihydroxy-; DIHYDROXYBENZOIC ACID, 3,4-; 3,4-Dihydroxybenzoate, VIII; 3, 4-Dihydroxybenzoic acid; Catechol-4-carboxylic Acid; 3,4-Dihydroxy Benzoic Acid; 3,4-dihydroxy-benzoic acid; 4,5-Dihydroxybenzoic acid; 3,4-Dihydroxybenzoic acid; PROTOCATECHUIC ACID (PCA); 2,4-dihydroxybenzoic acid; Protocatechuic acid (M1); PROTOCATECHUIC ACID [MI]; Protocatechuic Acid,(S); Carbohydroquinonic acid; 4,5-Dihydroxybenzoate; 3,4-dihydroxybenzoate; 2,4-Dihydroxybenzoate; beta-Resorcylic acid; Proto-catechuic acid; Protacatechuic Acid; protocatechuic acid; PROTOCATECHOIC ACID; protocatechuicacid; Protocatehuic acid; ProtocatechicAcid; b-resorcylic acid; beta-Resorcylate; protocatechuate; Hypogallic acid; UNII-36R5QJ8L4B; Protocatehuate; Protocatechuic; b-Resorcylate; ZINCSELENITE; Tox21_200167; CAS-99-50-3; KSC-10-128; 36R5QJ8L4B; 3,4-DHBA; cid_72; 1ykp; 4fht; Protocatechuic acid



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

46 个相关的代谢反应过程信息。

Reactome(44)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

900 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Teresa Deuchande, Joana F Fundo, Manuela E Pintado, Ana L Amaro. Protocatechuic acid as an inhibitor of lipid oxidation in meat. Meat science. 2024 Jul; 213(?):109519. doi: 10.1016/j.meatsci.2024.109519. [PMID: 38663116]
  • Karolina Jafernik, Paweł Kubica, Marta Sharafan, Aleksandra Kruk, Magdalena Anna Malinowska, Sebastian Granica, Agnieszka Szopa. Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures. Applied microbiology and biotechnology. 2024 May; 108(1):322. doi: 10.1007/s00253-024-13159-6. [PMID: 38713216]
  • Cem Baltacıoğlu, Hande Baltacıoğlu, İlhami Okur, Mehmet Yetişen, Hami Alpas. Recovery of phenolic compounds from peach pomace using conventional solvent extraction and different emerging techniques. Journal of food science. 2024 Mar; 89(3):1672-1683. doi: 10.1111/1750-3841.16972. [PMID: 38343298]
  • Jasmin Bayer, Petra Högger. Development and validation of a LC-MS/MS method for the quantification of phenolic compounds in human saliva after intake of a procyanidin-rich pine bark extract. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115914. doi: 10.1016/j.jpba.2023.115914. [PMID: 38101241]
  • Avery C Vilbert, Wayne S Kontur, Derek Gille, Daniel R Noguera, Timothy J Donohue. Engineering Novosphingobium aromaticivorans to produce cis,cis-muconic acid from biomass aromatics. Applied and environmental microbiology. 2024 Jan; 90(1):e0166023. doi: 10.1128/aem.01660-23. [PMID: 38117061]
  • Huafang Ding, Jianhui Liu, Zixing Chen, Shouhe Huang, Chi Yan, Erika Kwek, Zouyan He, Hanyue Zhu, Zhen-Yu Chen. Protocatechuic acid alleviates TMAO-aggravated atherosclerosis via mitigating inflammation, regulating lipid metabolism, and reshaping gut microbiota. Food & function. 2024 Jan; 15(2):881-893. doi: 10.1039/d3fo04396g. [PMID: 38165856]
  • Ning Li, Xia Du, Tong Qu, Hui Ren, Wenjing Lu, Xiaomin Cui, Jing Hu, Zhiyong Chen, Hongxun Tao. Pharmacodynamic material basis and pharmacological mechanisms of Cortex Mori against diabetes mellitus. Journal of ethnopharmacology. 2024 Jan; 324(?):117781. doi: 10.1016/j.jep.2024.117781. [PMID: 38253278]
  • Emad Hamdy Khedr, Nagwa Khedr. Enhancing productivity, modifying biochemical parameters, and regulating the phenylpropanoid pathway in 'Le-Conte' pears through optimal protocatechuic acid treatments. BMC plant biology. 2024 Jan; 24(1):50. doi: 10.1186/s12870-023-04715-9. [PMID: 38221634]
  • Inés Domínguez-López, Polina Galkina, Isabella Parilli-Moser, Camila Arancibia-Riveros, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Mireia Malcampo, J Alfredo Martínez, Lucas Tojal-Sierra, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Manuel Santos-Lozano, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A Tur, María Rubín-García, Xavier Pintó, Fernando Fernández-Aranda, Miguel Delgado-Rodríguez, Ana Barabash-Bustelo, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Estefania Toledo, Alessandro Atzeni, Eva M Asensio, Natàlia Vera, Antonio Garcia-Rios, Laura Torres-Collado, Napoleón Pérez-Farinós, Marian Zulet, Alice Chaplin, Rosa Casas, Sandra Martín-Peláez, Jessica Vaquero-Luna, Ana Maria Gómez-Pérez, Zenaida Vázquez-Ruiz, Sangeetha Shyam, Carolina Ortega-Azorín, Natàlia Talens, Patricia J Peña-Orihuela, Alejandro Oncina-Canovas, Javier Diez-Espino, Nancy Babio, Montserrat Fitó, Rosa M Lamuela-Raventós. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health. Molecular nutrition & food research. 2024 Jan; 68(2):e2300183. doi: 10.1002/mnfr.202300183. [PMID: 38062915]
  • Folake Asejeje, Sylvia Etim, Gbolahan Asejeje, Benneth Chukwudi Iwuoh, Sanmi Ibukunoluwa Akintade, Isaac Adedara, Ebenezer Olatunde Farombi. Protocatechuic acid modulates hepatic oxidative stress and inflammation linked to DMN exposure in rat. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2023 Dec; 38(2):145-155. doi: 10.54548/njps.v38i2.4. [PMID: 38696681]
  • Kaixia Xu, Guang Lu, Qianjin Feng, Shuangchao Chen, Yonghui Wang. Hepatoprotective effect of protocatechuic acid against type 2 diabetes-induced liver injury. Pharmaceutical biology. 2023 Dec; 61(1):737-745. doi: 10.1080/13880209.2023.2181359. [PMID: 37129023]
  • Huiqing Piao, Wanchen Xie, Shiqi Li, Jiaqi Wang, Chao Liu, Peng Quan, Liang Fang. Ternary Deep Eutectic Solvents System of Colchicine, 4-Hydroxyacetophenone, and Protocatechuic Acid and Characterization of Transdermal Enhancement Mechanism. AAPS PharmSciTech. 2023 Nov; 24(8):229. doi: 10.1208/s12249-023-02681-x. [PMID: 37964102]
  • Chun-Yan Yin, Yuan-Pei Lian, Jian-Da Xu, Chan-Ming Liu, Jia-Li Cai, Li Zhu, Di-Jun Wang, Li-Bo Luo, Xiao-Jing Yan. Study on network pharmacology of Ginkgo biloba extract against ischaemic stroke mechanism and establishment of UPLC-MS/MS methods for simultaneous determination of 19 main active components. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3286. [PMID: 37758241]
  • Nozomi Katsuki, Shunsuke Masuo, Noriyuki Nukui, Hajime Minakawa, Naoki Takaya. Gallic acid fermentation by metabolically engineered Escherichia coli producing p-hydroxybenzoate hydroxylase from Hylemonella gracilis NS1. The Journal of general and applied microbiology. 2023 Aug; ?(?):. doi: 10.2323/jgam.2023.08.004. [PMID: 37648467]
  • Tongjie Xiao, Mingyu Pan, Yuanxiao Wang, Yanjiao Huang, Makoto Tsunoda, Yingxia Zhang, Rong Wang, Wenting Hu, Haimei Yang, Lu-Shuang Li, Yanting Song. In vitro bloodbrain barrier permeability study of four main active ingredients from Alpiniae oxyphyllae fructus. Journal of pharmaceutical and biomedical analysis. 2023 Aug; 235(?):115637. doi: 10.1016/j.jpba.2023.115637. [PMID: 37634356]
  • Michael Sgro, Nicholas Chow, Farnaz Olyaie, Mark Arentshorst, Nicholas Geoffrion, Arthur F J Ram, Justin Powlowski, Adrian Tsang. Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger. The Journal of biological chemistry. 2023 Jul; ?(?):105003. doi: 10.1016/j.jbc.2023.105003. [PMID: 37399977]
  • Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis. Journal of ethnopharmacology. 2023 Jun; 310(?):116367. doi: 10.1016/j.jep.2023.116367. [PMID: 36914037]
  • Jin Li, Jianli Fu, Cheng Yue, Yanzhe Shang, Bang-Ce Ye. Highly Efficient Biosynthesis of Protocatechuic Acid via Recombinant Pseudomonas putida KT2440. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c01511. [PMID: 37365996]
  • Qiaoli Zhao, Liuping Fan, Jinwei Li. High internal phase emulsion gels stabilized by phosphorylated perilla protein isolate for protecting hydrophobic nutrients: Adjusting emulsion performance by incorporating chitosan-protocatechuic acid conjugate. International journal of biological macromolecules. 2023 Jun; 239(?):124101. doi: 10.1016/j.ijbiomac.2023.124101. [PMID: 36958452]
  • Sen Shi, Jiabo Cheng, Naveed Ahmad, Wenyan Zhao, Mengfei Tian, Zhanyu Yuan, Chunying Li, Chunjian Zhao. Effects of potential allelochemicals in a water extract of Abutilon theophrasti Medik. on germination and growth of Glycine max L., Triticum aestivum L., and Zea mays L. Journal of the science of food and agriculture. 2023 Mar; 103(4):2155-2165. doi: 10.1002/jsfa.12315. [PMID: 36369956]
  • Qiaoli Zhao, Liuping Fan, Yulin Zhou, Jinwei Li. Effect of chitosan-protocatechuic acid conjugate on stability and encapsulation capacity of polysaccharide-based high internal phase emulsion. Carbohydrate polymers. 2023 Mar; 304(?):120487. doi: 10.1016/j.carbpol.2022.120487. [PMID: 36641160]
  • Abeer Salama, Rania Elgohary, Mohamed M Amin, Sahar Abd Elwahab. Impact of protocatechuic acid on alleviation of pulmonary damage induced by cyclophosphamide targeting peroxisome proliferator activator receptor, silent information regulator type-1, and fork head box protein in rats. Inflammopharmacology. 2023 Mar; ?(?):. doi: 10.1007/s10787-023-01156-6. [PMID: 36877411]
  • Yuyao Xiang, Ruolan Huang, Yongliang Wang, Shanshan Han, Xiaochen Qin, Zhenzhen Li, Xu Wang, Yuqing Han, Tao Wang, Bo Xia, Jiangwei Wu, Gongshe Yang. Protocatechuic Acid Ameliorates High Fat Diet-Induced Obesity and Insulin Resistance in Mice. Molecular nutrition & food research. 2023 Feb; 67(3):e2200244. doi: 10.1002/mnfr.202200244. [PMID: 36285395]
  • Yan Liu, Yucheng Zhang, Keke Zhang, Yue Wang. Protocatechuic acid reduces H2O2-induced migration and oxidative stress of fibroblast-like synoviocytes in rheumatoid arthritis by activating Nrf2-Keap1 signaling pathway. The Chinese journal of physiology. 2023 Jan; 66(1):28-35. doi: 10.4103/cjop.cjop-d-22-00087. [PMID: 36814154]
  • Jijun Tan, Ruizhi Hu, Jiatai Gong, Chengkun Fang, Yanli Li, Ming Liu, Ziyu He, De-Xing Hou, Hongfu Zhang, Jianhua He, Shusong Wu. Protection against Metabolic Associated Fatty Liver Disease by Protocatechuic Acid. Gut microbes. 2023 Jan; 15(1):2238959. doi: 10.1080/19490976.2023.2238959. [PMID: 37505920]
  • Qian Zhang, Meixuan Li, Guiyan Yang, Xiaoqiang Liu, Zhongdong Yu, Shaobing Peng. Protocatechuic acid, ferulic acid and relevant defense enzymes correlate closely with walnut resistance to Xanthomonas arboricola pv. juglandis. BMC plant biology. 2022 Dec; 22(1):598. doi: 10.1186/s12870-022-03997-9. [PMID: 36539704]
  • Yajun Shen, Hengyang Li, Ding Xiaoying, Zhilai Zhan, Qi An, Yuguang Zheng, Dan Zhang. Optimization of Extraction and Quality Evaluation of Abri Herba by Response Surface Methodology Combined with Quantitative Analysis of Multi-Components by Single Marker. Journal of AOAC International. 2022 Nov; ?(?):. doi: 10.1093/jaoacint/qsac149. [PMID: 36383190]
  • Kendal Erdem Duman, Abdulahad Dogan, Burak Kaptaner. Ameliorative role of Cyanus depressus (M.Bieb.) Soják plant extract against diabetes-associated oxidative-stress-induced liver, kidney, and pancreas damage in rats. Journal of food biochemistry. 2022 10; 46(10):e14314. doi: 10.1111/jfbc.14314. [PMID: 35802765]
  • Qiaoli Zhao, Liuping Fan, Yuanfa Liu, Jinwei Li. Fabrication of chitosan-protocatechuic acid conjugates to inhibit lipid oxidation and improve the stability of β-carotene in Pickering emulsions: Effect of molecular weight of chitosan. International journal of biological macromolecules. 2022 Sep; 217(?):1012-1026. doi: 10.1016/j.ijbiomac.2022.07.222. [PMID: 35926669]
  • Solomon E Owumi, Samuel A Bello, Temitope B Idowu, Uche O Arunsi, Adegboyega K Oyelere. Protocatechuic acid protects against hepatorenal toxicities in rats exposed to Furan. Drug and chemical toxicology. 2022 Jul; 45(4):1840-1850. doi: 10.1080/01480545.2021.1890109. [PMID: 33645375]
  • Ruiyang Sun, Ying Zhang, Weiwei Tang, Bin Li. Submicron 3,4-dihydroxybenzoic acid-TiO2 composite particles for enhanced MALDI MS imaging of secondary metabolites in the root of differently aged baical skullcap. The Analyst. 2022 Jun; 147(13):3017-3024. doi: 10.1039/d2an00710j. [PMID: 35639347]
  • Charatda Punvittayagul, Theerapat Luangsuphabool, Rawiwan Wongpoomchai. Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis. Scientific reports. 2022 06; 12(1):10548. doi: 10.1038/s41598-022-14888-2. [PMID: 35732709]
  • Heena Khan, Amarjot Kaur Grewal, Manish Kumar, Thakur Gurjeet Singh. Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia-Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway. Neuroscience. 2022 05; 491(?):23-31. doi: 10.1016/j.neuroscience.2022.03.016. [PMID: 35314251]
  • Rehab S Abdelrahman, Ghada S El-Tanbouly. Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/ IL-17/ IL-23 immunoinflammatory pathway. Toxicology and applied pharmacology. 2022 04; 440(?):115931. doi: 10.1016/j.taap.2022.115931. [PMID: 35202709]
  • Rami B Kassab, Abdulrahman Theyab, Ali O Al-Ghamdy, Mohammad Algahtani, Ahmad H Mufti, Khalaf F Alsharif, Ehab M Abdella, Ola A Habotta, Mohamed M Omran, Maha S Lokman, Amira A Bauomy, Ashraf Albrakati, Roua S Baty, Khalid E Hassan, Maha A Alshiekheid, Ahmed E Abdel Moneim, Heba A Elmasry. Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats. Environmental science and pollution research international. 2022 Feb; 29(8):12208-12221. doi: 10.1007/s11356-021-16578-4. [PMID: 34562213]
  • Hui Li, Tingting Zheng, Fuzhi Lian, Tong Xu, Wenya Yin, Yugang Jiang. Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer's disease. Nutrition (Burbank, Los Angeles County, Calif.). 2022 Jan; 93(?):111473. doi: 10.1016/j.nut.2021.111473. [PMID: 34739938]
  • Yunxiao Gao, Rongrong Tian, Haiyue Liu, Huimin Xue, Ruizhe Zhang, Suping Han, Lin Ji, Weidong Huang, Jicheng Zhan, Yilin You. Research progress on intervention effect and mechanism of protocatechuic acid on nonalcoholic fatty liver disease. Critical reviews in food science and nutrition. 2022; 62(32):9053-9075. doi: 10.1080/10408398.2021.1939265. [PMID: 34142875]
  • Ziqiang Li, Xi Du, Yanfen Li, Ruihua Wang, Changxiao Liu, Yanguang Cao, Weidang Wu, Jinxia Sun, Baohe Wang, Yuhong Huang. Pharmacokinetics of gallic acid and protocatechuic acid in humans after dosing with Relinqing (RLQ) and the potential for RLQ-perpetrated drug-drug interactions on organic anion transporter (OAT) 1/3. Pharmaceutical biology. 2021 Dec; 59(1):757-768. doi: 10.1080/13880209.2021.1934039. [PMID: 34144662]
  • Hyun-Kyung Song, Sun Haeng Park, Hye Jin Kim, Seol Jang, Taesoo Kim. Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Dec; 144(?):112322. doi: 10.1016/j.biopha.2021.112322. [PMID: 34656059]
  • Yimin Zhao, Zouyan He, Wangjun Hao, Hanyue Zhu, Jianhui Liu, Ka Ying Ma, Wen-Sen He, Zhen-Yu Chen. Cholesterol-lowering activity of protocatechuic acid is mediated by increasing the excretion of bile acids and modulating gut microbiota and producing short-chain fatty acids. Food & function. 2021 Nov; 12(22):11557-11567. doi: 10.1039/d1fo02906a. [PMID: 34709262]
  • Lulu Meng, Cuicui Sun, Liyong Gao, Muhammad Saleem, Baohua Li, Caixia Wang. Hydroxybenzoate hydroxylase genes underlying protocatechuic acid production in Valsa mali are required for full pathogenicity in apple trees. Molecular plant pathology. 2021 11; 22(11):1370-1382. doi: 10.1111/mpp.13119. [PMID: 34390112]
  • Rosaria Acquaviva, Barbara Tomasello, Claudia Di Giacomo, Rosa Santangelo, Alfonsina La Mantia, Irina Naletova, Maria Grazia Sarpietro, Francesco Castelli, Giuseppe Antonio Malfa. Protocatechuic Acid, a Simple Plant Secondary Metabolite, Induced Apoptosis by Promoting Oxidative Stress through HO-1 Downregulation and p21 Upregulation in Colon Cancer Cells. Biomolecules. 2021 10; 11(10):. doi: 10.3390/biom11101485. [PMID: 34680118]
  • Marwa E Abdelmageed, Manar A Nader, Marwa S Zaghloul. Targeting HMGB1/TLR4/NF-κB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats. European journal of pharmacology. 2021 Sep; 906(?):174279. doi: 10.1016/j.ejphar.2021.174279. [PMID: 34197778]
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