Vanillate (BioDeep_00000859393)

Main id: BioDeep_00000000082

 

PANOMIX_OTCML-2023 natural product BioNovoGene_Lab2019


代谢物信息卡片


4-Hydroxy-3-methoxybenzoic acid

化学式: C8H8O4 (168.0422568)
中文名称: 香草酸
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-07-24.

Cite this Page

Vanillate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/vanillate (retrieved 2024-11-09) (BioDeep RN: BioDeep_00000859393). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COC1=C(C=CC(=C1)C(=O)O)O
InChI: InChI=1S/C8H8O4/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,9H,1H3,(H,10,11)

描述信息

Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects[1].
Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects[1].

同义名列表

32 个代谢物同义名

InChI=1\C8H8O4\c1-12-7-4-5(8(10)11)2-3-6(7)9\h2-4,9H,1H3,(H,10,11; Protocatechuic acid, 3-methyl ester; Benzoic acid, 4-hydroxy-3-methoxy-; p-Hydroxy-m-methoxy-benzonic acid; 4-hydroxy-3-methoxy-Benzoic acid; 4-Hydroxy-3-methoxybenzoic Acid; 3-Methoxy-4-hydroxybenzoic acid; m-Anisic acid, 4-hydroxy-; EINECS 204-466-8; Acide vanillique; WLN: QVR DQ CO1; p-Vanillic acid; W398802_ALDRICH; H36001_ALDRICH; Vanillic Acid; SMR000156289; MLS000574833; 94770_FLUKA; BRN 2208364; AIDS-018089; CHEBI:30816; AIDS018089; NSC 674322; SBB008280; NSC674322; AI3-19542; 121-34-6; NSC 3987; VA (VAN); NSC3987; C06672; VA



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1540 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jin Li, Jianli Fu, Yanzhe Shang, Wenping Wei, Ping Zhang, Xue Wang, Bang-Ce Ye. Metabolic Engineering of Pseudomonas putida KT2440 for De Novo Biosynthesis of Vanillic Acid. Journal of agricultural and food chemistry. 2024 Feb; 72(8):4217-4224. doi: 10.1021/acs.jafc.3c07828. [PMID: 38356383]
  • Shahab Ghaderi, Parsa Gholipour, Alireza Komaki, Siamak Shahidi, Faezeh Seif, Mohammad Bahrami-Tapehebur, Iraj Salehi, Mohammad Zarei, Abdolrahman Sarihi, Masome Rashno. Underlying mechanisms behind the neuroprotective effect of vanillic acid against diabetes-associated cognitive decline: An in vivo study in a rat model. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8111. [PMID: 38185917]
  • Eman S Alamri, Haddad A El Rabey. The Protective Effects of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles (AgNPs) in Streptozotocin-Induced Diabetic Rats. Journal of diabetes research. 2024; 2024(?):4873544. doi: 10.1155/2024/4873544. [PMID: 38577302]
  • Yan Wang, Chao-Bing Luo, Yuan-Qiu Li. Biofuneling lignin-derived compounds into lipids using a newly isolated Citricoccus sp. P2. Bioresource technology. 2023 Nov; 387(?):129669. doi: 10.1016/j.biortech.2023.129669. [PMID: 37573985]
  • Jieyi Wu, Zhaohui Song, Nan Cai, Ningning Cao, Qingguo Wang, Xuefeng Xiao, Xiaokun Yang, Yi He, Shuxuan Zou. Pharmacokinetics, tissue distribution and excretion of six bioactive components from total glucosides picrorhizae rhizoma, as simultaneous determined by a UHPLC-MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2023 Jul; 1227(?):123830. doi: 10.1016/j.jchromb.2023.123830. [PMID: 37459691]
  • Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis. Journal of ethnopharmacology. 2023 Jun; 310(?):116367. doi: 10.1016/j.jep.2023.116367. [PMID: 36914037]
  • Mohammad Shabani, Zhaleh Jamali, Deniz Bayrami, Ahmad Salimi. Vanillic acid alleviates methamphetamine-induced mitochondrial toxicity in cardiac mitochondria via antioxidant activity and inhibition of MPT Pore opening: an in-vitro study. BMC pharmacology & toxicology. 2023 05; 24(1):33. doi: 10.1186/s40360-023-00676-9. [PMID: 37208773]
  • Banafsheh Yalameha, Hamid Reza Nejabati, Mohammad Nouri. Cardioprotective potential of vanillic acid. Clinical and experimental pharmacology & physiology. 2023 Mar; 50(3):193-204. doi: 10.1111/1440-1681.13736. [PMID: 36370144]
  • Natarajan Ashokkumar, Kolanji Vinothiya. Protective Impact of Vanillic Acid on Lipid Profile and Lipid Metabolic Enzymes in Diabetic Hypertensive Rat Model Generated by A High-Fat Diet. Current drug discovery technologies. 2023 Feb; ?(?):. doi: 10.2174/1570163820666230224100643. [PMID: 36825708]
  • Rajamohanan Jalaja Anish, Biji Mohanan, Thankamani Ravikumar Aswathy, Aswathy Nair, K V Radhakrishnan, Arun A Rauf. An integrated approach to the structural characterization, long-term toxicological and anti-inflammatory evaluation of Pterospermum rubiginosum bark extract. Journal of ethnopharmacology. 2023 Feb; 308(?):116262. doi: 10.1016/j.jep.2023.116262. [PMID: 36796743]
  • Sreelekshmi Mohan, Anupama Nair, M S Poornima, K G Raghu. Vanillic acid mitigates hyperinsulinemia induced ER stress mediated altered calcium homeostasis, MAMs distortion and surplus lipogenesis in HepG2 cells. Chemico-biological interactions. 2023 Feb; ?(?):110365. doi: 10.1016/j.cbi.2023.110365. [PMID: 36764371]
  • Fei Sun, Xiang-Qin Wu, Yue Qi, Xing-Yu Chen, Yu-Hua Cao, Jian-Gang Wang, Shu-Mei Wang, Sheng-Wang Liang. [Application of partial least squares algorithm to explore bioactive components of crude and stir-baked hawthorn for invigorating spleen and promoting digestion]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Feb; 48(4):958-965. doi: 10.19540/j.cnki.cjcmm.20220712.302. [PMID: 36872266]
  • Tong-Il Hyeon, Kyung-Sup Yoon. Ethosome Containing Ceramide as a Skin Carrier of Active Ingredients. Current drug delivery. 2023; 20(7):927-942. doi: 10.2174/1567201819666220720123737. [PMID: 35864796]
  • Linyan Zhao, Wumei Xu, Huilin Guan, Kunyan Wang, Ping Xiang, Fugang Wei, Shaozhou Yang, Cuiping Miao, Lena Q Ma. Biochar increases Panax notoginseng's survival under continuous cropping by improving soil properties and microbial diversity. The Science of the total environment. 2022 Dec; 850(?):157990. doi: 10.1016/j.scitotenv.2022.157990. [PMID: 35963414]
  • Eman S Alamri, Haddad A El Rabey, Othman R Alzahrani, Fahad M Almutairi, Eman S Attia, Hala M Bayomy, Renad A Albalwi, Samar M Rezk. Enhancement of the Protective Activity of Vanillic Acid against Tetrachloro-Carbon (CCl4) Hepatotoxicity in Male Rats by the Synthesis of Silver Nanoparticles (AgNPs). Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238308. [PMID: 36500401]
  • Sompong Sansenya, Apirak Payaka. Inhibitory potential of phenolic compounds of Thai colored rice (Oryza sativa L.) against α-glucosidase and α-amylase through in vitro and in silico studies. Journal of the science of food and agriculture. 2022 Nov; 102(14):6718-6726. doi: 10.1002/jsfa.12039. [PMID: 35620810]
  • Leila Kebal, Katarzyna Pokajewicz, Noureddine Djebli, Nadjet Mostefa, Anna Poliwoda, Piotr P Wieczorek. HPLC-DAD profile of phenolic compounds and In vitro antioxidant activity of Ficus carica L. fruits from two Algerian varieties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113738. doi: 10.1016/j.biopha.2022.113738. [PMID: 36182734]
  • Shirley A Micallef, Sanghyun Han, Louisa Martinez. Tomato Cultivar Nyagous Fruit Surface Metabolite Changes during Ripening Affect Salmonella Newport. Journal of food protection. 2022 11; 85(11):1604-1613. doi: 10.4315/jfp-22-160. [PMID: 36048925]
  • Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi. Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats. BMC immunology. 2022 10; 23(1):50. doi: 10.1186/s12865-022-00519-y. [PMID: 36261807]
  • Hatice Kiziltas, Ahmet Ceyhan Goren, Saleh H Alwasel, İlhami Gulcin. Sahlep (Dactylorhiza osmanica): Phytochemical Analyses by LC-HRMS, Molecular Docking, Antioxidant Activity, and Enzyme Inhibition Profiles. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206907. [PMID: 36296499]
  • Qian Wu, Abid Naeem, Jiamei Zou, Chengqun Yu, Yingjie Wang, Jingbin Chen, Yuhui Ping. Isolation of Phenolic Compounds from Raspberry Based on Molecular Imprinting Techniques and Investigation of Their Anti-Alzheimer's Disease Properties. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206893. [PMID: 36296486]
  • Arzu Kavaz, Mesut Işık, Emrah Dikici, Mehmet Yüksel. Anticholinergic, Antioxidant, and Antibacterial Properties of Vitex Agnus-Castus L. Seed Extract: Assessment of Its Phenolic Content by LC/MS/MS. Chemistry & biodiversity. 2022 Oct; 19(10):e202200143. doi: 10.1002/cbdv.202200143. [PMID: 36075867]
  • Jagat Pal Yadav, Maria Grishina, Mohd Shahbaaz, Alok Mukerjee, Sunil Kumar Singh, Prateek Pathak. Cucumis melo var. momordica as a Potent Antidiabetic, Antioxidant and Possible Anticovid Alternative: Investigation through Experimental and Computational Methods. Chemistry & biodiversity. 2022 Sep; 19(9):e202200200. doi: 10.1002/cbdv.202200200. [PMID: 35950335]
  • Kajal Sinha, Shiv Kumar, Bindu Rawat, Rahul Singh, Rituraj Purohit, Dinesh Kumar, Yogendra Padwad. Kutkin, iridoid glycosides enriched fraction of Picrorrhiza kurroa promotes insulin sensitivity and enhances glucose uptake by activating PI3K/Akt signaling in 3T3-L1 adipocytes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154204. doi: 10.1016/j.phymed.2022.154204. [PMID: 35671635]
  • B Ogunlade, S C Gbotolorun, O A Adedotun, K A Itiere, J A Adejayi. VANILLIC ACID AND VITAMIN C ATTENUATED DEHP-INDUCED TESTICULAR TOXICITY IN MALE RATS. Reproduction & fertility. 2022 Aug; ?(?):. doi: 10.1530/raf-22-0045. [PMID: 35980228]
  • Jianxin Song, Yong Shao, Xiaoxu Chen, Xihong Li. Release of characteristic phenolics of quinoa based on extrusion technique. Food chemistry. 2022 Apr; 374(?):128780. doi: 10.1016/j.foodchem.2020.128780. [PMID: 34083060]
  • Brahmjot Singh, Ajay Kumar, Hasandeep Singh, Sarabjit Kaur, Saroj Arora, Balbir Singh. Protective effect of vanillic acid against diabetes and diabetic nephropathy by attenuating oxidative stress and upregulation of NF-κB, TNF-α and COX-2 proteins in rats. Phytotherapy research : PTR. 2022 Mar; 36(3):1338-1352. doi: 10.1002/ptr.7392. [PMID: 35088468]
  • Yuan Liang, Tiancheng Ma, Yuwei Li, Na Cai. A rapid and sensitive LC-MS/MS method for the determination of vanillic acid in rat plasma with application to pharmacokinetic study. Biomedical chromatography : BMC. 2022 Jan; 36(1):e5248. doi: 10.1002/bmc.5248. [PMID: 34555192]
  • Kaoutar Benrahou, Hanae Naceiri Mrabti, Saad Fettach, Mohamed Reda Kachmar, Mostafa Kouach, Jean-François Goossens, Latifa Doudach, Shafi Mahmud, Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh, Abdelhakim Bouyahya, My El Abbes Faouzi. Mineral and Phenolic Composition of Erodium guttatum Extracts and Investigation of Their Antioxidant Properties in Diabetic Mice. Oxidative medicine and cellular longevity. 2022; 2022(?):4229981. doi: 10.1155/2022/4229981. [PMID: 36193070]
  • Ifedolapo M Oke, Limpho M Ramorobi, Samson S Mashele, Susanna L Bonnet, Tshepiso J Makhafola, Kenneth C Eze, Anwar E M Noreljaleel, Chika I Chukwuma. Vanillic acid-Zn(II) complex: a novel complex with antihyperglycaemic and anti-oxidative activity. The Journal of pharmacy and pharmacology. 2021 Dec; 73(12):1703-1714. doi: 10.1093/jpp/rgab086. [PMID: 34109975]
  • Xiaomiao Tan, Jiangyu Zhu, Minato Wakisaka. Effect of phytochemical vanillic acid on the growth and lipid accumulation of freshwater microalga Euglena gracilis. World journal of microbiology & biotechnology. 2021 Nov; 37(12):217. doi: 10.1007/s11274-021-03185-1. [PMID: 34773155]
  • Alicia P Cárdenas-Castro, Víctor M Zamora-Gasga, Emilio Alvarez-Parrilla, Víctor M Ruíz-Valdiviezo, Koen Venema, Sonia G Sáyago-Ayerdi. In vitro gastrointestinal digestion and colonic fermentation of tomato (Solanum lycopersicum L.) and husk tomato (Physalis ixocarpa Brot.): Phenolic compounds released and bioconverted by gut microbiota. Food chemistry. 2021 Oct; 360(?):130051. doi: 10.1016/j.foodchem.2021.130051. [PMID: 34020365]
  • Kássia Caroline Figueredo, Camille Gaube Guex, Andreia Regina Haas da Silva, Cibele Lima Lhamas, Ana Martiele Engelmann, Roberto Marinho Maciel, Cristiane Cademartori Danesi, Thiago Duarte, Marta Maria Medeiros Frescura Duarte, Gilberti Helena Hübscher Lopes, Liliane de Freitas Bauermann. In silico and in vivo protective effect of Morus nigra leaves on oxidative damage induced by iron overload. Drug and chemical toxicology. 2021 Oct; ?(?):1-11. doi: 10.1080/01480545.2021.1991946. [PMID: 34663156]
  • Mohamed Z M Salem, Hayssam M Ali, Mohammad Akrami. Moringa oleifera seeds-removed ripened pods as alternative for papersheet production: antimicrobial activity and their phytoconstituents profile using HPLC. Scientific reports. 2021 09; 11(1):19027. doi: 10.1038/s41598-021-98415-9. [PMID: 34561493]
  • Pradeep Singh, Muhammad Arif, Abdul Qadir, Pushpendra Kannojia. Simultaneous Analytical Efficiency Evaluation Using an HPTLC Method for the Analysis of Syringic Acid and Vanillic Acid and Their Anti-Oxidant Capacity from Methanol Extract of Ricinus communis L. and Euphorbia hirta L. Journal of AOAC International. 2021 Aug; 104(4):1188-1195. doi: 10.1093/jaoacint/qsaa171. [PMID: 33351060]
  • Joel B Johnson, Daniel J Skylas, Janice S Mani, Jinle Xiang, Kerry B Walsh, Mani Naiker. Phenolic Profiles of Ten Australian Faba Bean Varieties. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154642. [PMID: 34361795]
  • Nesa Ahmadi, Naser Mirazi, Alireza Komaki, Samaneh Safari, Abdolkarim Hosseini. Vanillic acid attenuates amyloid β1-40-induced long-term potentiation deficit in male rats: an in vivo investigation. Neurological research. 2021 Jul; 43(7):562-569. doi: 10.1080/01616412.2021.1893565. [PMID: 33627050]
  • Pedro H S Cesar, Marcus V Trento, Thais A Sales, Anderson A Simão, Teodorico C Ramalho, Silvana Marcussi. Vanillic acid as phospholipase A2 and proteases inhibitor: In vitro and computational analyses. Biotechnology and applied biochemistry. 2021 Jun; 68(3):486-496. doi: 10.1002/bab.1943. [PMID: 32420666]
  • Lavhelesani R Managa, Elsa S du Toit, Gerhard Prinsloo. NMR-Based Metabolomic Analyses to Identify the Effect of Harvesting Frequencies on the Leaf Metabolite Profile of a Moringa oleifera Cultivar Grown in an Open Hydroponic System. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082298. [PMID: 33921119]
  • Nedra Slama, Houda Mankai, Ferid Limam. Streptomyces tunisiensis DSM 42037 mediated bioconversion of ferulic acid released from barley bran. World journal of microbiology & biotechnology. 2021 Mar; 37(4):70. doi: 10.1007/s11274-021-03031-4. [PMID: 33748917]
  • Sepideh Shekari, Fatemeh Khonsha, Mohammad Rahmati-Yamchi, Hamid R Nejabati, Ali Mota. Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues. Current pharmaceutical design. 2021; 27(46):4686-4692. doi: 10.2174/1381612827666210701145438. [PMID: 34218773]
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  • Caroline Lambrecht Dittgen, Jessica Fernanda Hoffmann, Fábio Clasen Chaves, Cesar Valmor Rombaldi, José Manoel Colombari Filho, Nathan Levien Vanier. Discrimination of genotype and geographical origin of black rice grown in Brazil by LC-MS analysis of phenolics. Food chemistry. 2019 Aug; 288(?):297-305. doi: 10.1016/j.foodchem.2019.03.006. [PMID: 30902297]
  • Jianzeng Liu, Xiaohao Xu, Rui Jiang, Liwei Sun, Daqing Zhao. Vanillic acid in Panax ginseng root extract inhibits melanogenesis in B16F10 cells via inhibition of the NO/PKG signaling pathway. Bioscience, biotechnology, and biochemistry. 2019 Jul; 83(7):1205-1215. doi: 10.1080/09168451.2019.1606694. [PMID: 30999826]
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