Isorhamnetin (BioDeep_00000001359)

   

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs


代谢物信息卡片


4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-

化学式: C16H12O7 (316.05830019999996)
中文名称: 异鼠李素
谱图信息: 最多检出来源 Viridiplantae(plant) 1%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O)c1ccc(c(c1)OC)O)O)O
InChI: InChI=1/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3

描述信息

Isorhamnetin is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. However, it is found in human plasma as conjugates with glucuronic acid, sulfate or methyl groups, with no significant amounts of free quercetin present. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to its in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells. (PMID: 15493462, 17368593, 17374653, 16963021).
Isorhamnetin is a monomethoxyflavone that is quercetin in which the hydroxy group at position 3 is replaced by a methoxy group. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, an anticoagulant and a metabolite. It is a 7-hydroxyflavonol, a tetrahydroxyflavone and a monomethoxyflavone. It is functionally related to a quercetin. It is a conjugate acid of an isorhamnetin(1-).
Isorhamnetin is a natural product found in Lotus ucrainicus, Strychnos pseudoquina, and other organisms with data available.
Isorhamnetin is a metabolite found in or produced by Saccharomyces cerevisiae.
See also: Peumus boldus leaf (part of).
Widespread flavonol found especially in bee pollen, chives, corn poppy leaves, garden cress, fennel, hartwort, red onions, pears, dillweed, parsley and tarragon. Isorhamnetin is found in many foods, some of which are italian sweet red pepper, carrot, yellow wax bean, and lemon balm.
A monomethoxyflavone that is quercetin in which the hydroxy group at position 3 is replaced by a methoxy group.
Acquisition and generation of the data is financially supported in part by CREST/JST.
Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.
Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.

同义名列表

60 个代谢物同义名

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy-; 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-benzopyran-4-one; Isorhamnetin, United States Pharmacopeia (USP) Reference Standard; 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one #; 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one; 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-one; 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxy-phenyl)chromen-4-one; 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone; 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one; Isorhamnetin, primary pharmaceutical reference standard; 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl); ISORHAMNETIN (CONSTITUENT OF GINKGO) [DSC]; Flavone, 3-methoxy-3,4,5,7-tetrahydroxy-; FLAVONE, 3,4,5,7-TETRAHYDROXY-3-METHOXY-; 3,4’,5,7-Tetrahydroxy-3’-methoxyflavone; 3,4,5,7-tetrahydroxy-3-methoxy-flavone; 3-Methoxy-3,4,5,7-tetrahydroxyflavone; 3,4,5,7-tetrahydroxy-3-methoxyflavone; 3,5,7,4-Tetrahydroxy-3-methoxyflavone; ISORHAMNETIN (CONSTITUENT OF GINKGO); Isorhamnetin, analytical standard; 3-Methylquercetin (Isorhamnetin); Isorhamnetin, >=95.0\\% (HPLC); IZQSVPBOUDKVDZ-UHFFFAOYSA-N; Quercetin 3’-methyl ether; Quercetin 3-methyl ether; quercetin-3-methyl ether; ISORHAMNETIN (USP-RS); METHYLQUERCETIN, 3-O-; ISORHAMNETIN [USP-RS]; 3’-O-Methylquercetin; 3’-Methoxyquercetin; 3-O-methylquercetin; 4-O-Methylquercetin; ISORHAMNETIN [INCI]; 3-O-Methylquercetin; 3-Methoxyquercetin; 3-Methylquercetine; 3’-Methylquercetin; 4-Methoxyquercetin; 3-methyl-quercetin; 3-methylquercetin; 3-Methylquercetin; -4H-chromen-4-one; 4-Methylquercetin; UNII-07X3IB4R4Z; Isorhanetin,(S); isorhamnetine; iso-rhamnetin; Oprea1_145406; MEGxp0_001863; Isorhamnetin; Isorhamnetol; ACon1_000275; 07X3IB4R4Z; IRH; 3 4 5 7-tetrahydroxy-3-methoxy flavone; 3'-Methylquercetin



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(2)

代谢反应

90 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(89)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1248 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jia Jian, Li Yu-Qing, Han Rang-Yue, Zhong Xia, Xie Ke-Huan, Yan Ying, Wang Li, Tan Rui-Zhi. Isorhamnetin ameliorates cisplatin-induced acute kidney injury in mice by activating SLPI-mediated anti-inflammatory effect in macrophage. Immunopharmacology and immunotoxicology. 2024 Jun; 46(3):319-329. doi: 10.1080/08923973.2024.2329621. [PMID: 38466121]
  • Xiaojuan Li, Tao Wang, Qilong Zhou, Fan Li, Ting Liu, Kun Zhang, Ao Wen, Lijuan Feng, Xiaoling Shu, Simin Tian, Yijiang Liu, Yu Gao, Qing Xia, Guang Xin, Wen Huang. Isorhamnetin Alleviates Mitochondrial Injury in Severe Acute Pancreatitis via Modulation of KDM5B/HtrA2 Signaling Pathway. International journal of molecular sciences. 2024 Mar; 25(7):. doi: 10.3390/ijms25073784. [PMID: 38612598]
  • Lingkun Wang, Yaochen Xie, Boneng Xiao, Xuelin He, Guanghui Ying, Huiyan Zha, Chen Yang, Xuejin Jin, Guilin Li, Li Ping, Jincheng Wang, Qinjie Weng. Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation. Free radical biology & medicine. 2024 Feb; 212(?):22-33. doi: 10.1016/j.freeradbiomed.2023.12.010. [PMID: 38101584]
  • Xue-Feng Shi, Qi Yu, Kai-Bo Wang, Yi-Dong Fu, Shun Zhang, Zhen-Yun Liao, Yan Li, Ting Cai. Active ingredients Isorhamnetin of Croci Srigma inhibit stomach adenocarcinomas progression by MAPK/mTOR signaling pathway. Scientific reports. 2023 08; 13(1):12607. doi: 10.1038/s41598-023-39627-z. [PMID: 37537191]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Hong Wang, Lijia Chen, Binrui Yang, Jun Du, Liang Chen, Yiming Li, Fujiang Guo. Structures, Sources, Identification/Quantification Methods, Health Benefits, Bioaccessibility, and Products of Isorhamnetin Glycosides as Phytonutrients. Nutrients. 2023 Apr; 15(8):. doi: 10.3390/nu15081947. [PMID: 37111165]
  • Tianshu Yang, Yi Xiao, Shuo Liu, Fazhen Luo, Dongyun Tang, Yilin Yu, Yan Xie. Isorhamnetin induces cell cycle arrest and apoptosis by triggering DNA damage and regulating the AMPK/mTOR/p70S6K signaling pathway in doxorubicin-resistant breast cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154780. doi: 10.1016/j.phymed.2023.154780. [PMID: 37004402]
  • Peng Zhang, Yisheng Sun, Lei Shi, Dekang Sun, Lin Wang, Dongdong Feng, Chao Ding. Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway. Tissue & cell. 2023 Mar; 82(?):102048. doi: 10.1016/j.tice.2023.102048. [PMID: 36905861]
  • Fei Yu, Yanfeng Xue, Yunyan Zhao, Long Zhang, Xiao He, Zheng Liu. Isorhamnetin inhibits inflammatory response to alleviate DHEA-induced polycystic ovary syndrome in rats. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2023 Feb; ?(?):2183045. doi: 10.1080/09513590.2023.2183045. [PMID: 36842967]
  • Maitane González-Arceo, Iván Gomez-Lopez, Helen Carr-Ugarte, Itziar Eseberri, Marcela González, M Pilar Cano, María P Portillo, Saioa Gómez-Zorita. Anti-Obesity Effects of Isorhamnetin and Isorhamnetin Conjugates. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010299. [PMID: 36613743]
  • Anna Stochmal, Agata Rolnik, Bartosz Skalski, Jerzy Zuchowski, Beata Olas. Antiplatelet and Anticoagulant Activity of Isorhamnetin and Its Derivatives Isolated from Sea Buckthorn Berries, Measured in Whole Blood. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144429. [PMID: 35889302]
  • Vanessa Pittol, Kleyton Santos Veras, Eduarda Doneda, Ariane Dorneles Silva, Maria Gabriele Delagustin, Letícia Scherer Koester, Valquíria Linck Bassani. The challenge of flavonoid/cyclodextrin complexation in a complex matrix of the quercetin, luteolin, and 3-O-methylquercetin. Pharmaceutical development and technology. 2022 Jul; 27(6):625-634. doi: 10.1080/10837450.2022.2098326. [PMID: 35796030]
  • Huseyin Gungor, Mehmet Ekici, Mehmet Burak Ates. Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice. Drug and chemical toxicology. 2022 May; ?(?):1-9. doi: 10.1080/01480545.2022.2069256. [PMID: 35502492]
  • Feten Zar Kalai, Mondher Boulaaba, Farhana Ferdousi, Hiroko Isoda. Effects of Isorhamnetin on Diabetes and Its Associated Complications: A Review of In Vitro and In Vivo Studies and a Post Hoc Transcriptome Analysis of Involved Molecular Pathways. International journal of molecular sciences. 2022 Jan; 23(2):. doi: 10.3390/ijms23020704. [PMID: 35054888]
  • Fuqi Wang, Xu Zhao, Xin Su, Danni Song, Fengmao Zou, Lina Fang. Isorhamnetin, the xanthine oxidase inhibitor from Sophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice. Food & function. 2021 Dec; 12(24):12503-12512. doi: 10.1039/d1fo02719k. [PMID: 34806108]
  • M Antunes-Ricardo, D Guardado-Félix, M R Rocha-Pizaña, J Garza-Martínez, L Acevedo-Pacheco, J A Gutiérrez-Uribe, J Villela-Castrejón, F López-Pacheco, S O Serna-Saldívar. Opuntia ficus-indica Extract and Isorhamnetin-3-O-Glucosyl-Rhamnoside Diminish Tumor Growth of Colon Cancer Cells Xenografted in Immune-Suppressed Mice through the Activation of Apoptosis Intrinsic Pathway. Plant foods for human nutrition (Dordrecht, Netherlands). 2021 Dec; 76(4):434-441. doi: 10.1007/s11130-021-00934-3. [PMID: 34786663]
  • Yingzhuan Zhan, Wenjing Ta, Wenjuan Tang, Ruochen Hua, Jue Wang, Cheng Wang, Wen Lu. Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro. Drug development research. 2021 12; 82(8):1124-1130. doi: 10.1002/ddr.21815. [PMID: 33847382]
  • Haowen Li, Manzhen Li, Jingxin Fu, Hui Ao, Weihua Wang, Xiangtao Wang. Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions. Drug delivery. 2021 Dec; 28(1):1226-1236. doi: 10.1080/10717544.2021.1927244. [PMID: 34142631]
  • Aiziguli Mulati, Xin Zhang, Tong Zhao, Bo Ren, Luanfeng Wang, Xiaoning Liu, Ying Lan, Xuebo Liu. Isorhamnetin attenuates high-fat and high-fructose diet induced cognitive impairments and neuroinflammation by mediating MAPK and NFκB signaling pathways. Food & function. 2021 Oct; 12(19):9261-9272. doi: 10.1039/d0fo03165h. [PMID: 34606526]
  • Eduarda Doneda, Sara Elis Bianchi, Vanessa Pittol, Tainá Kreutz, Juliete Nathali Scholl, Irene L Ibañez, Candelaria Bracalente, Hebe Durán, Fabrício Figueiró, Fábio Klamt, Valquiria Linck Bassani. 3-O-Methylquercetin from Achyrocline satureioides-cytotoxic activity against A375-derived human melanoma cell lines and its incorporation into cyclodextrins-hydrogels for topical administration. Drug delivery and translational research. 2021 10; 11(5):2151-2168. doi: 10.1007/s13346-020-00882-6. [PMID: 33410099]
  • Ece Sevgi, Aydan Dag, Çağla Kızılarslan-Hançer, Sezen Atasoy, Belma Zengin Kurt, Öznur Aksakal. Evaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine. Journal of ethnopharmacology. 2021 Aug; 276(?):114211. doi: 10.1016/j.jep.2021.114211. [PMID: 34015367]
  • Ahmed A Zaki, Xiaoqian Xu, Yuewen Wang, Pei-Hsin Shie, Longxin Qiu. A new anti-inflammatory flavonoid glycoside from tetraena aegyptia. Natural product research. 2021 Jun; 35(12):1985-1990. doi: 10.1080/14786419.2019.1650356. [PMID: 31397172]
  • Ling Li, Xiao-Jie Jin, Jia-Wei Li, Cheng-Hao Li, Shuang-Yan Zhou, Jun-Jie Li, Cai-Qin Feng, Dong-Ling Liu, Yong-Qi Liu. Systematic insight into the active constituents and mechanism of Guiqi Baizhu for the treatment of gastric cancer. Cancer science. 2021 May; 112(5):1772-1784. doi: 10.1111/cas.14851. [PMID: 33682294]
  • Fei Chen, Minwei Hu, Yue Shen, Wenjun Zhu, Ailin Cao, Bin Ni, Jiao Qian, Jun Yang. Isorhamnetin promotes functional recovery in rats with spinal cord injury by abating oxidative stress and modulating M2 macrophages/microglia polarization. European journal of pharmacology. 2021 Mar; 895(?):173878. doi: 10.1016/j.ejphar.2021.173878. [PMID: 33453223]
  • Marwa Matboli, Doaa Ibrahim, Amany H Hasanin, Mohamed K Hassan, Eman K Habib, Miram M Bekhet, Ahmed M Afifi, Sanaa Eissa. Epigenetic modulation of autophagy genes linked to diabetic nephropathy by administration of isorhamnetin in Type 2 diabetes mellitus rats. Epigenomics. 2021 02; 13(3):187-202. doi: 10.2217/epi-2020-0353. [PMID: 33406900]
  • Jordan M Chapman, Gloria K Muday. Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana. The Journal of biological chemistry. 2021 Jan; 296(?):100222. doi: 10.1074/jbc.ra120.014543. [PMID: 33839683]
  • Zhi Chang, Jia-Ling Wang, Zhi-Cheng Jing, Ping Ma, Qing-Bing Xu, Jian-Rong Na, Jie Tian, Xuan Ma, Wei Zhou, Ru Zhou. Protective effects of isorhamnetin on pulmonary arterial hypertension: in vivo and in vitro studies. Phytotherapy research : PTR. 2020 Oct; 34(10):2730-2744. doi: 10.1002/ptr.6714. [PMID: 32452118]
  • Sara E Bianchi, Melissa A Pegues, Camila K Dias, Francesca Mascia, Eduarda Doneda, Vanessa Pittol, V Ashutosh Rao, Fábio Klamt, Valquiria L Bassani. Achyrocline satureioides compounds, achyrobichalcone and 3-O-methylquercetin, induce mitochondrial dysfunction and apoptosis in human breast cancer cell lines. IUBMB life. 2020 10; 72(10):2133-2145. doi: 10.1002/iub.2348. [PMID: 32710804]
  • Gang Gong, Ying-Yun Guan, Zhong-Lin Zhang, Khalid Rahman, Su-Juan Wang, Shuang Zhou, Xin Luan, Hong Zhang. Isorhamnetin: A review of pharmacological effects. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Aug; 128(?):110301. doi: 10.1016/j.biopha.2020.110301. [PMID: 32502837]
  • Jeffrey P Davis, Mihoko Koyanagi, Robert R Maronpot, Leslie Recio, Shim-Mo Hayashi. Identification of compound causing yellow bone discoloration following alpha-glycosyl isoquercitrin exposure in Sprague-Dawley rats. Archives of toxicology. 2020 07; 94(7):2413-2421. doi: 10.1007/s00204-020-02760-z. [PMID: 32388820]
  • Maiko Sakai, Kohta Ohnishi, Masashi Masuda, Hirokazu Ohminami, Hisami Yamanaka-Okumura, Taichi Hara, Yutaka Taketani. Isorhamnetin, a 3'-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner. Bioscience, biotechnology, and biochemistry. 2020 Jun; 84(6):1221-1231. doi: 10.1080/09168451.2020.1727309. [PMID: 32046625]
  • Edgar Jesús Delgado-Núñez, Alejandro Zamilpa, Manasés González-Cortazar, Agustín Olmedo-Juárez, Alexandre Cardoso-Taketa, Ernesto Sánchez-Mendoza, Daniel Tapia-Maruri, David Osvaldo Salinas-Sánchez, Pedro Mendoza-de Gives. Isorhamnetin: A Nematocidal Flavonoid from Prosopis Laevigata Leaves Against Haemonchus Contortus Eggs and Larvae. Biomolecules. 2020 05; 10(5):. doi: 10.3390/biom10050773. [PMID: 32429307]
  • Cristian López-Palacios, Cecilia B Peña-Valdivia. Screening of secondary metabolites in cladodes to further decode the domestication process in the genus Opuntia (Cactaceae). Planta. 2020 Mar; 251(4):74. doi: 10.1007/s00425-020-03371-9. [PMID: 32144512]
  • Debanjana Bhattacharya, Ritam Sinha, Priyadarshini Mukherjee, Debaki Ranjan Howlader, Dhrubajyoti Nag, Soumyadev Sarkar, Hemanta Koley, Jeffrey H Withey, Ratan Gachhui. Anti-virulence activity of polyphenolic fraction isolated from Kombucha against Vibrio cholerae. Microbial pathogenesis. 2020 Mar; 140(?):103927. doi: 10.1016/j.micpath.2019.103927. [PMID: 31846743]
  • Wei-Chen Xiong, He-Zhen Wu, Yi-Yi Xiong, Bo Liu, Zhou-Tao Xie, Song-Tao Wu, Yun-Feng Yao, Yan-Fang Yang. Network Pharmacology-based Research of Active Components of Albiziae Flos and Mechanisms of Its Antidepressant Effect. Current medical science. 2020 Feb; 40(1):123-129. doi: 10.1007/s11596-020-2155-7. [PMID: 32166674]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Elhadi E Elamir, Abdulrhman A Almadiy, Gomah E Nenaah, Abdullah A Alabas, Hajer S Alsaqri. Comparing six mathematical link function models of the antifeedant activity of lesser grain borer exposed to sub-lethal concentrations of some extracts from calotropis procera. Bioengineered. 2019 12; 10(1):292-305. doi: 10.1080/21655979.2019.1641399. [PMID: 31284815]
  • Maja Budeč, Jasna Bošnir, Aleksandar Racz, Dario Lasić, Danijel Brkić, Ana Mosović Ćuić, Željka Kuharić, Gordana Jurak, Lidija Barušić. VERIFICATION OF AUTHENTICITY OF GINKGO BILOBA L. LEAF EXTRACT AND ITS PRODUCTS PRESENT ON THE CROATIAN MARKET BY ANALYSIS OF QUANTITY AND RATIO OF GINKGO FLAVONE GLYCOSIDES (QUERCETIN, KAEMPFEROL AND ISORHAMNETIN) TO TERPENE TRILACTONES TO THE EFFECT OF UNMASKING COUNTERFEIT DRUGS ENDANGERING PATIENT HEALTH. Acta clinica Croatica. 2019 Dec; 58(4):672-692. doi: 10.20471/acc.2019.58.04.15. [PMID: 32595253]
  • Munkhzul Ganbold, Yohei Owada, Yusuke Ozawa, Yasuhiro Shimamoto, Farhana Ferdousi, Kenichi Tominaga, Yun-Wen Zheng, Nobuhiro Ohkohchi, Hiroko Isoda. Isorhamnetin Alleviates Steatosis and Fibrosis in Mice with Nonalcoholic Steatohepatitis. Scientific reports. 2019 11; 9(1):16210. doi: 10.1038/s41598-019-52736-y. [PMID: 31700054]
  • Anil Kumar Chauhan, Jieun Kim, Yeongjoon Lee, Pavithra K Balasubramanian, Yangmee Kim. Isorhamnetin Has Potential for the Treatment of Escherichia coli-Induced Sepsis. Molecules (Basel, Switzerland). 2019 Nov; 24(21):. doi: 10.3390/molecules24213984. [PMID: 31689976]
  • Marilena Antunes-Ricardo, Annia Hernández-Reyes, Ashanti C Uscanga-Palomeque, Cristina Rodríguez-Padilla, Ana Carolina Martínez-Torres, Janet Alejandra Gutiérrez-Uribe. Isorhamnetin glycoside isolated from Opuntia ficus-indica (L.) MilI induces apoptosis in human colon cancer cells through mitochondrial damage. Chemico-biological interactions. 2019 Sep; 310(?):108734. doi: 10.1016/j.cbi.2019.108734. [PMID: 31276661]
  • Sen-Wei Tsai, Chi-Chien Lin, Shih-Chao Lin, Shun-Ping Wang, Deng-Ho Yang. Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis. Immunopharmacology and immunotoxicology. 2019 Aug; 41(4):504-512. doi: 10.1080/08923973.2019.1641723. [PMID: 31342791]
  • Jerzy Żuchowski, Łukasz Pecio, Beata Marciniak, Renata Kontek, Anna Stochmal. Unusual isovalerylated flavonoids from the fruit of sea buckthorn (Elaeagnus rhamnoides) grown in Sokółka, Poland. Phytochemistry. 2019 Jul; 163(?):178-186. doi: 10.1016/j.phytochem.2019.03.001. [PMID: 30952449]
  • Huan-Huan Zhu, Ju-Xiang Yang, Chu-Han Xiao, Tian-Yu Mao, Jie Zhang, Hong-Yan Zhang. Differences in flavonoid pathway metabolites and transcripts affect yellow petal colouration in the aquatic plant Nelumbo nucifera. BMC plant biology. 2019 Jun; 19(1):277. doi: 10.1186/s12870-019-1886-8. [PMID: 31234776]
  • Gen Wang, Qi Cui, Lu-Jun Yin, Xue Zheng, Ming-Zhu Gao, Yao Meng, Wei Wang. Efficient extraction of flavonoids from Flos Sophorae Immaturus by tailored and sustainable deep eutectic solvent as green extraction media. Journal of pharmaceutical and biomedical analysis. 2019 Jun; 170(?):285-294. doi: 10.1016/j.jpba.2018.12.032. [PMID: 30951994]
  • Srijita Sireswar, Gargi Dey. Matrix-wise evaluation of in vivo and in vitro efficiencies of L. rhamnosus GG-fortified beverages. Food research international (Ottawa, Ont.). 2019 05; 119(?):908-919. doi: 10.1016/j.foodres.2018.10.077. [PMID: 30884731]
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