Quertin (BioDeep_00000859378)

Main id: BioDeep_00000270734

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-

化学式: C15H10O7 (302.0427)
中文名称: 槲皮素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
InChI: InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

描述信息

COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D020011 - Protective Agents > D000975 - Antioxidants
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

同义名列表

139 个代谢物同义名

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; 3,5,7-Trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-on; 2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-chromenone; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone; 5-18-05-00494 (Beilstein Handbook Reference); Quercetin; 3,3,4,5,7-Pentahydroxyflavone; WLN: T66 BO EVJ CR CQ DQ & DQ GQ IQ; Flavone, 3,3,4,5,7-pentahydroxy-; Flavone, 3,4,5,5,7-pentahydroxy-; 3,4,5,7-Tetrahydroxyflavan-3-ol; 3,4,5,7-tetrahydroxyflavon-3-ol; 3,3,4,5,7-pentahydroxyflavone; 3,5,7,3,4-Pentahydroxyflavone; 3,3,4,5,7-Pentahydroxyflavone; C.I. Natural yellow 10 & 13; 7255-55-2 (ZIRCONIUM SALT); NSC58588 (ZIRCONIUM SALT); NSC57655 (ALUMINUM SALT); NChemBio.2007.10-comp11; C.I. Natural Yellow 10; 6151-25-3 (DIHYDRATE); CI Natural Yellow 10; 117-39-5 (NEUTRAL ); T-Gelb bzw. grun 1; C.I. Natural red 1; Prestwick1_000507; Kvercetin [Czech]; Prestwick0_000507; Maybridge1_008992; Natural Yellow 10; Prestwick3_000507; NSC9219 (NEUTRAL); Quercetin content; Prestwick2_000507; Cyanidelonon 1522; Spectrum5_001389; EINECS 204-187-1; Spectrum2_000059; Spectrum3_000642; BiomolKI2_000068; UPCMLD-DP081:001; Spectrum4_000807; NCGC00015870-02; BiomolKI_000062; NCGC00025016-05; Spectrum_000124; NCGC00015870-03; NCGC00025016-01; NCIOpen2_007628; SPECTRUM1500672; NCGC00025016-08; NCGC00025016-07; NCGC00015870-01; NCIOpen2_007882; NCGC00025016-03; Flavin meletin; MixCom3_000183; KBioSS_000584; A1784\0075599; DivK1c_000485; BSPBio_002243; KBioGR_001293; MEGxp0_000381; BSPBio_000433; Lopac0_000999; BPBio1_000477; KBioGR_000408; KBioSS_000408; BSPBio_001068; KBio3_000776; KBio3_001463; KBio2_002976; KBio2_000584; NCI60_042036; KBio2_005720; KBio2_005544; BAS 00649429; KBio2_000408; NINDS_000485; SPBio_000217; KBio2_003152; KBio1_000485; Lopac-Q-0125; ACon1_000560; SPBio_002354; KBio3_000775; ZINC03861279; Bio1_000858; IDI1_000485; Bio2_000854; BRN 0317313; Bio1_000369; CHEBI:16243; Xanthaurine; IDI1_002129; SMP1_000252; Bio1_001347; AIDS-000487; Bio2_000374; Tocris-1125; AIDS000487; CCRIS 1639; Sophoretin; 73123-10-1; SGCUT00001; NCI-C60106; EU-0100999; C.I. 75670; Quercetine; 74893-81-5; HSDB 3529; to_000078; Quercetol; Quercitin; Quercetin; AI3-26018; NSC 9219; Quertine; TNP00089; NSC 9221; CI 75670; 117-39-5; LNS-5662; TNP00070; Quertin; CPD-520; NSC9219; Meletin; C00389; K00029; S00057; c0808; QUE; Quercetin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1777 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ACE2, AKR1B1, CASP8, CYP3A4, ESR1, PIK3C3, PRKX, PTGS1, TNK1, TYR, XDH
Peripheral membrane protein 4 CYP1B1, ESR1, PTGS1, TNK1
Endoplasmic reticulum membrane 3 CYP1B1, CYP3A4, PTGS1
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 4 CASP8, ESR1, JUN, PRKX
autophagosome 1 PIK3C3
cytosol 6 AKR1B1, CASP8, ESR1, LIPE, PIK3C3, XDH
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 6 AKR1B1, ATP2B1, CASP8, ESR1, JUN, PRKX
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 5 ACE2, ATP2B1, ESR1, LIPE, MGAM
Cytoplasmic side 1 ESR1
lamellipodium 1 CASP8
Multi-pass membrane protein 1 ATP2B1
Synapse 1 ATP2B1
cell surface 1 ACE2
glutamatergic synapse 2 ATP2B1, PIK3C3
Golgi apparatus 2 ESR1, PTGS1
lysosomal membrane 1 EGF
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 LIPE
Lysosome 1 TYR
endosome 1 PIK3C3
plasma membrane 8 ACE2, ATP2B1, BCHE, EGF, ESR1, IGHE, MGAM, TNK1
synaptic vesicle membrane 1 ATP2B1
Membrane 10 ACE2, ATP2B1, CYP1B1, CYP3A4, EGF, ESR1, LIPE, MGAM, PIK3C3, TNK1
apical plasma membrane 2 ACE2, MGAM
basolateral plasma membrane 1 ATP2B1
caveola 1 LIPE
extracellular exosome 6 ACE2, AKR1B1, ATP2B1, EGF, MGAM, PTGS1
extracellular space 7 ACE2, AKR1B1, BCHE, CRP, EGF, IGHE, XDH
perinuclear region of cytoplasm 1 TYR
mitochondrion 3 AKR1B1, CASP8, CYP1B1
protein-containing complex 2 CASP8, ESR1
intracellular membrane-bounded organelle 5 ATP2B1, CYP1B1, CYP3A4, PTGS1, TYR
Microsome membrane 3 CYP1B1, CYP3A4, PTGS1
Single-pass type I membrane protein 3 ACE2, IGHE, TYR
Secreted 4 ACE2, BCHE, CRP, MGAM
extracellular region 6 ACE2, BCHE, CRP, EGF, IGHE, MGAM
Single-pass membrane protein 1 MGAM
mitochondrial outer membrane 1 CASP8
transcription regulator complex 2 ESR1, JUN
Cell projection, cilium 1 ACE2
photoreceptor outer segment 1 PTGS1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Melanosome membrane 1 TYR
midbody 1 PIK3C3
Golgi-associated vesicle 1 TYR
Apical cell membrane 1 ACE2
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 ACE2
GABA-ergic synapse 1 PIK3C3
Peroxisome 2 PIK3C3, XDH
sarcoplasmic reticulum 1 XDH
lateral plasma membrane 1 ATP2B1
axoneme 1 PIK3C3
Late endosome 1 PIK3C3
neuron projection 1 PTGS1
cilium 1 ACE2
chromatin 2 ESR1, JUN
IgE immunoglobulin complex 1 IGHE
cell projection 1 ATP2B1
phagocytic vesicle membrane 1 PIK3C3
cytoskeleton 1 CASP8
brush border membrane 1 ACE2
nuclear chromosome 1 JUN
blood microparticle 1 BCHE
Basolateral cell membrane 1 ATP2B1
[Isoform 2]: Cell membrane 1 IGHE
Endomembrane system 1 PTGS1
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
tertiary granule membrane 1 MGAM
Melanosome 1 TYR
euchromatin 2 ESR1, JUN
Presynaptic cell membrane 1 ATP2B1
cell body 1 CASP8
endoplasmic reticulum lumen 2 ACE2, BCHE
platelet alpha granule lumen 1 EGF
endocytic vesicle membrane 1 ACE2
immunological synapse 1 ATP2B1
presynaptic endosome 1 PIK3C3
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 EGF
[Isoform 1]: Nucleus 1 ESR1
ficolin-1-rich granule membrane 1 MGAM
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 1 CASP8
ripoptosome 1 CASP8
[Isoform 3]: Cell membrane 1 IGHE
postsynaptic endosome 1 PIK3C3
transcription factor AP-1 complex 1 JUN
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
Autolysosome 1 PIK3C3
photoreceptor ribbon synapse 1 ATP2B1
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Yanying Ren, Rui Zhu, Xiaojuan You, Dengzhou Li, Mengyu Guo, Bing Fei, Ying Liu, Ximing Yang, Xinwei Liu, Yongwei Li. Quercetin: a promising virulence inhibitor of Pseudomonas aeruginosa LasB in vitro. Applied microbiology and biotechnology. 2024 Dec; 108(1):57. doi: 10.1007/s00253-023-12890-w. [PMID: 38180553]
  • Libo Wang, Yilin Huang, Yanjuan Ren, Haoran Wang, Yue Ding, Guangyue Ren, Tongtong Wang, Zaigui Li, Ju Qiu. Effect of ethanol addition on the physicochemical, structural and in vitro digestive properties of Tartary buckwheat starch-quercetin/rutin complexes. Food chemistry. 2024 Sep; 451(?):139350. doi: 10.1016/j.foodchem.2024.139350. [PMID: 38663246]
  • Yunsong Jiang, Mengzhen Xing, Jinyuan Sun, Xin-An Zeng, Charles Brennan, Jayani Chandrapala, Mahsa Majzoobi, Baoguo Sun. Construction of resveratrol and quercetin nanoparticles based on folic acid targeted Maillard products between Jiuzao glutelin isolate and carboxymethyl chitosan: Improved stability and function. Food chemistry. 2024 Aug; 450(?):139296. doi: 10.1016/j.foodchem.2024.139296. [PMID: 38636381]
  • Qiteng Ding, Wencong Liu, Shuai Zhang, Shuwen Sun, Jiali Yang, Lifeng Zhang, Ning Wang, Shuang Ma, Guodong Chai, Liqian Shen, Yang Gao, Chuanbo Ding, Xinglong Liu. Hydrogel loaded with thiolated chitosan modified taxifolin liposome promotes osteoblast proliferation and regulates Wnt signaling pathway to repair rat skull defects. Carbohydrate polymers. 2024 Jul; 336(?):122115. doi: 10.1016/j.carbpol.2024.122115. [PMID: 38670750]
  • Vishnu S, Sibaprasad Maity, Annada C Maity, Malavika S Kumar, Malay Dolai, Anish Nag, Yatheesharadhya Bylappa, Gorachand Dutta, Bimalendu Mukherjee, Avijit Kumar Das. Development of a fluorescent scaffold by utilizing quercetin template for selective detection of Hg2+: Experimental and theoretical studies along with live cell imaging. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 Jul; 315(?):124249. doi: 10.1016/j.saa.2024.124249. [PMID: 38603957]
  • Komaldeep Kaur, Yogesh A Kulkarni, Sarika Wairkar. Exploring the potential of quercetin in Alzheimer's Disease: Pharmacodynamics, Pharmacokinetics, and Nanodelivery systems. Brain research. 2024 Jul; 1834(?):148905. doi: 10.1016/j.brainres.2024.148905. [PMID: 38565372]
  • Jiawen Liu, Hongrui Yu, Jianglong Kong, Xiaohan Ge, Yuting Sun, Meiru Mao, David Y Wang, Yi Wang. Preparation, characterization, stability, and controlled release of chitosan-coated zein/shellac nanoparticles for the delivery of quercetin. Food chemistry. 2024 Jun; 444(?):138634. doi: 10.1016/j.foodchem.2024.138634. [PMID: 38330608]
  • Hafidha Mehallah, Noureddine Djebli, Pham Ngoc Khanh, Nguyen Xuan Ha, Vu Thi Ha, Tran Thu Huong, Do Dinh Tung, Nguyen Manh Cuong. In silico and in vivo study of anti-inflammatory activity of Morinda longissima (Rubiaceae) extract and phytochemicals for treatment of inflammation-mediated diseases. Journal of ethnopharmacology. 2024 Jun; 328(?):118051. doi: 10.1016/j.jep.2024.118051. [PMID: 38493905]
  • Xue Li, Jiao Song, Jin Tan, Dingkun Zhang, Yongmei Guan, Funeng Geng, Ming Yang, Jin Pei, Hongyan Ma. 'Plant Golden' C. sativus: Qualitative and quantitative analysis of major components in stigmas and petals and their biological activity in vitro. Journal of pharmaceutical and biomedical analysis. 2024 Jun; 243(?):116115. doi: 10.1016/j.jpba.2024.116115. [PMID: 38513497]
  • Xufeng Bai, Shuwen Wang, Limei Shu, Qingyu Cao, Huiming Hu, Yanchen Zhu, Chen Chen. Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice. Journal of ethnopharmacology. 2024 Jun; 327(?):118006. doi: 10.1016/j.jep.2024.118006. [PMID: 38442806]
  • Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of ethnopharmacology. 2024 Jun; 327(?):117999. doi: 10.1016/j.jep.2024.117999. [PMID: 38447616]
  • Yanping Wu, Ziyan Tang, Shumin Du, Jing Dai, Jintao Shen, Hong Niu, Xingshuang Song, Guiyu Huang, Lina Du, Yiguang Jin. Oral quercetin nanoparticles in hydrogel microspheres alleviate high-altitude sleep disturbance based on the gut-brain axis. International journal of pharmaceutics. 2024 Jun; 658(?):124225. doi: 10.1016/j.ijpharm.2024.124225. [PMID: 38750982]
  • M Mesud Hurkul, Ahmet Cetinkaya, Seyda Yayla, S Irem Kaya, Fatma Budak, Kenan Can Tok, Mehmet Gumustas, Lokman Uzun, Sibel A Ozkan. Highly selective and sensitive molecularly imprinted sensors for the electrochemical assay of quercetin in methanol extracts of Rubus sanctus and Fragaria vesca. Talanta. 2024 Jun; 273(?):125883. doi: 10.1016/j.talanta.2024.125883. [PMID: 38521023]
  • Xuanyi Yang, Baojie Wang, Keyong Jiang, Kefeng Xu, Chen Zhong, Mei Liu, Lei Wang. The combined analysis of transcriptomics and metabolomics reveals the mechanisms by which dietary quercetin regulates growth and immunity in Penaeus vannamei. Fish & shellfish immunology. 2024 Jun; 149(?):109579. doi: 10.1016/j.fsi.2024.109579. [PMID: 38648996]
  • Jia Jian, Li Yu-Qing, Han Rang-Yue, Zhong Xia, Xie Ke-Huan, Yan Ying, Wang Li, Tan Rui-Zhi. Isorhamnetin ameliorates cisplatin-induced acute kidney injury in mice by activating SLPI-mediated anti-inflammatory effect in macrophage. Immunopharmacology and immunotoxicology. 2024 Jun; 46(3):319-329. doi: 10.1080/08923973.2024.2329621. [PMID: 38466121]
  • Zhanli Liu, Zhiming Shan, Haoyi Yang, Yanmei Xing, Weijie Guo, Jing Cheng, Yuanxu Jiang, Song Cai, Chaoran Wu, Jessica Aijia Liu, Chi Wai Cheung, Yunping Pan. Quercetin, Main Active Ingredient of Moutan Cortex, Alleviates Chronic Orofacial Pain via Block of Voltage-Gated Sodium Channel. Anesthesia and analgesia. 2024 Jun; 138(6):1324-1336. doi: 10.1213/ane.0000000000006730. [PMID: 37968831]
  • Daniela Pastorim Vaiss, Jamile Lima Rodrigues, Virginia Campello Yurgel, Frank do Carmo Guedes, Lauanda Larissa Mendonça da Matta, Paula Alice Bezerra Barros, Gustavo Richter Vaz, Raíssa Nunes Dos Santos, Bibiana Franzen Matte, Larine Kupski, Jaqueline Garda-Buffon, Juliana Bidone, Ana Luiza Muccillo-Baisch, Fabio Sonvico, Cristiana Lima Dora. Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: A promising therapeutic and prophylactic treatment for viral respiratory infections. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jun; 197(?):106766. doi: 10.1016/j.ejps.2024.106766. [PMID: 38615970]
  • Yuqiao Zeng, Yiyu He, Li Wang, Hao Xu, Qianwen Zhang, Yanjun Wang, Jianhua Zhang, Likun Wang. Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1/p53 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155533. doi: 10.1016/j.phymed.2024.155533. [PMID: 38552433]
  • Shuangyu Wu, Ye Tian, Qiying Zhang, Zhujing Fu, Huizhen Lan, Xuanle Zhou, Ling Ma, Yiyun Lou. Protective effect of quercetin on lipopolysaccharide‑induced miscarriage based on animal experiments and network pharmacology. Molecular medicine reports. 2024 06; 29(6):. doi: 10.3892/mmr.2024.13223. [PMID: 38606505]
  • Marija Bruić, Andrea Pirković, Sunčica Borozan, Mirjana Nacka Aleksić, Milica Jovanović Krivokuća, Biljana Spremo-Potparević. Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line. Reproductive toxicology (Elmsford, N.Y.). 2024 Jun; 126(?):108585. doi: 10.1016/j.reprotox.2024.108585. [PMID: 38574953]
  • Hongxia Li, Zhiqiang Cao, Chang Liu, Yu Wang, Lili Wang, Yuhan Tang, Ping Yao. Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis. Journal of agricultural and food chemistry. 2024 May; 72(21):12156-12170. doi: 10.1021/acs.jafc.4c01134. [PMID: 38755521]
  • Yupei Liao, Xiaoqing Xie, Chu Zhang, Haijing Zhong, Luchen Shan, Pei Yu, Lipeng Xu. Quercetin exerts anti-tumor immune mechanism by regulating IL-6/JAK2/STAT3 signaling pathway to deplete Treg cells. Toxicon : official journal of the International Society on Toxinology. 2024 May; 243(?):107747. doi: 10.1016/j.toxicon.2024.107747. [PMID: 38714236]
  • Bingqing Chi, Meng Zhang, Luping Sun, Hongyan Liu, Zhenhua Tian. Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats. Food & function. 2024 May; 15(10):5627-5640. doi: 10.1039/d3fo02641h. [PMID: 38722076]
  • Daijin Li, Jie Chang, Yujue Wang, Xiaoye Du, Jing Xu, Jingang Cui, Teng Zhang, Yu Chen. Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation. Acta neuropathologica communications. 2024 May; 12(1):76. doi: 10.1186/s40478-024-01793-0. [PMID: 38755736]
  • Yanying Zhang, Xinyan Zhu, Yuanzhong Wang-. Development of machine learning models using multi-source data for geographical traceability and content prediction of Eucommia ulmoides leaves. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 May; 313(?):124136. doi: 10.1016/j.saa.2024.124136. [PMID: 38467098]
  • Kseniya Bushmeleva, Alexandra Vyshtakalyuk, Dmitriy Terenzhev, Timur Belov, Evgeniy Nikitin, Vladimir Zobov. Effect of Flavonols of Aronia melanocarpa Fruits on Morphofunctional State of Immunocompetent Organs of Rats under Cyclophosphamide-Induced Immunosuppression. Biomolecules. 2024 May; 14(5):. doi: 10.3390/biom14050578. [PMID: 38785985]
  • Yiwen Tao, Jia Liu, Mengjia Li, Hongling Wang, Gang Fan, Xiaolong Xie, Xing Fu, Jinsong Su. Abelmoschus manihot (L.) medik. seeds alleviate rheumatoid arthritis by modulating JAK2/STAT3 signaling pathway. Journal of ethnopharmacology. 2024 May; 325(?):117641. doi: 10.1016/j.jep.2023.117641. [PMID: 38151179]
  • Xiao-Yu Zhang, Kai-Rou Xia, Ya-Ni Wang, Pei Liu, Er-Xin Shang, Cong-Yan Liu, Yu-Ping Liu, Ding Qu, Wei-Wen Li, Jin-Ao Duan, Yan Chen, Huang-Qin Zhang. Unraveling the pharmacodynamic substances and possible mechanism of Trichosanthis Pericarpium in the treatment of coronary heart disease based on plasma pharmacochemistry, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 325(?):117869. doi: 10.1016/j.jep.2024.117869. [PMID: 38342153]
  • Shuo Tan, Linmei Wu, Jiayi Liu, Zhaoyuan Wu, Qiang Cheng, Qiuhao Qu, Lianghao Zhu, Yizhu Yan, Hao Wu, Tie-Jun Ling, Rui-Tian Liu, Shigao Yang. Quercetin-3-O-glc-1-3-rham-1-6-glucoside decreases Aβ production, inhibits Aβ aggregation and neurotoxicity, and prohibits the production of inflammatory cytokines. European journal of pharmacology. 2024 May; 970(?):176491. doi: 10.1016/j.ejphar.2024.176491. [PMID: 38503399]
  • Safaa I Khater, Mahran Mohamed Abd El-Emam, Hussein Abdellatif, Mahmoud Mostafa, Tarek Khamis, Rania Hassan Mohamed Soliman, Heba S Ahmed, Sahar K Ali, Heba Mohammed Refat M Selim, Leena S Alqahtani, Doaa Habib, Mohamed M M Metwally, Anwar M Alnakhli, Asmaa Saleh, Amira Mohammed Abdelfattah, Hanim M Abdelnour, Mohamed F Dowidar. Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA. Life sciences. 2024 May; 344(?):122546. doi: 10.1016/j.lfs.2024.122546. [PMID: 38462227]
  • Lian Wang, Bing Xiong, Wei Lu, Yujie Cheng, Jihui Zhu, Guihai Ai, Xiaojie Zhang, Xiuni Liu, Zhongping Cheng. Senolytic drugs dasatinib and quercetin combined with Carboplatin or Olaparib reduced the peritoneal and adipose tissue metastasis of ovarian cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116474. doi: 10.1016/j.biopha.2024.116474. [PMID: 38518604]
  • Qi-Yang Wang, Hao-Yu Wang, Wei-Guo Zhang, Jian-Zhong Xu. Economical one-pot synthesis of isoquercetin and D-allulose from quercetin and sucrose using whole-cell biocatalyst. Enzyme and microbial technology. 2024 May; 176(?):110412. doi: 10.1016/j.enzmictec.2024.110412. [PMID: 38402828]
  • Natali Joma, Patrick-Brian Bielawski, Anjali Saini, Ashok Kakkar, Dusica Maysinger. Nanocarriers for natural polyphenol senotherapeutics. Aging cell. 2024 May; 23(5):e14178. doi: 10.1111/acel.14178. [PMID: 38685568]
  • Guodong Chai, Ning Wang, Meiling Xu, Lina Ma, Xinglong Liu, Qiteng Ding, Shuai Zhang, Anning Li, Guofeng Xia, Yingchun Zhao, Wencong Liu, Dadong Liang, Chuanbo Ding. Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing. International journal of biological macromolecules. 2024 May; 268(Pt 2):131670. doi: 10.1016/j.ijbiomac.2024.131670. [PMID: 38643919]
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  • Xiufen Dong, Xianfeng Liu, Lina Cheng, Ruizhen Li, Siqi Ge, Sai Wang, Yue Cai, Yang Liu, Sida Meng, Cai-Zhong Jiang, Chun-Lin Shi, Tianlai Li, Daqi Fu, Mingfang Qi, Tao Xu. SlBEL11 regulates flavonoid biosynthesis, thus fine-tuning auxin efflux to prevent premature fruit drop in tomato. Journal of integrative plant biology. 2024 Apr; 66(4):749-770. doi: 10.1111/jipb.13627. [PMID: 38420861]
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  • Arwa R Althaher, Sawsan A Oran, Mirna W Awadallah, Hanan H Ameen, Reham F Shehabi, Laurance M S Bourghli, Andrea Mastinu. Chemical Composition, Antioxidant, and Antibacterial Activity of Ruta chalepensis L. Ethanolic Extract. Chemistry & biodiversity. 2024 Apr; 21(4):e202400026. doi: 10.1002/cbdv.202400026. [PMID: 38372467]
  • Ju Huang, Jian Chen, Jingnan Li. Quercetin promotes ATG5-mediating autophagy-dependent ferroptosis in gastric cancer. Journal of molecular histology. 2024 Apr; 55(2):211-225. doi: 10.1007/s10735-024-10186-5. [PMID: 38441713]
  • Qiteng Ding, Xinglong Liu, Xuexia Liu, Guodong Chai, Ning Wang, Shuang Ma, Lifeng Zhang, Shuai Zhang, Jiali Yang, Yanjun Wang, Liqian Shen, Chuanbo Ding, Wencong Liu. Polyvinyl alcohol/carboxymethyl chitosan-based hydrogels loaded with taxifolin liposomes promote diabetic wound healing by inhibiting inflammation and regulating autophagy. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130226. doi: 10.1016/j.ijbiomac.2024.130226. [PMID: 38368971]
  • Xiaojuan Li, Tao Wang, Qilong Zhou, Fan Li, Ting Liu, Kun Zhang, Ao Wen, Lijuan Feng, Xiaoling Shu, Simin Tian, Yijiang Liu, Yu Gao, Qing Xia, Guang Xin, Wen Huang. Isorhamnetin Alleviates Mitochondrial Injury in Severe Acute Pancreatitis via Modulation of KDM5B/HtrA2 Signaling Pathway. International journal of molecular sciences. 2024 Mar; 25(7):. doi: 10.3390/ijms25073784. [PMID: 38612598]
  • Basireh Fattahpour, Mohammad Fattahi, Abbas Hassani. Essential oil composition, morphological characterization, phenolic content and antioxidant activity of Iranian populations of Hymenocrater longiflorus Benth. (Lamiaceae). Scientific reports. 2024 03; 14(1):7239. doi: 10.1038/s41598-024-57826-0. [PMID: 38538705]
  • Noha Mokhtar Abd-El-Aziz, Mohamed Saeed Hifnawy, Rehab Ahmed Lotfy, Inas Youssef Younis. LC/MS/MS and GC/MS/MS metabolic profiling of Leontodon hispidulus, in vitro and in silico anticancer activity evaluation targeting hexokinase 2 enzyme. Scientific reports. 2024 03; 14(1):6872. doi: 10.1038/s41598-024-57288-4. [PMID: 38519553]
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  • Enning Zhou, Qiangqiang Li, Rui Xu, Fei Pan, Yuxiao Tao, Xiangxin Li, Xiaofeng Xue, Liming Wu. Covalent conjugation with quercetin mitigates allergenicity of the bee pollen allergen Bra c p in a murine model. Food chemistry. 2024 Mar; 436(?):137722. doi: 10.1016/j.foodchem.2023.137722. [PMID: 37857207]
  • Olivia Wyse Faria, Mayara Sandrielly Soares de Aguiar, Julia Eisenhardt de Mello, Fernando Lopez Alvez, Karina Pereira Luduvico, Driele Neske Garcia, Augusto Schneider, Michal M Masternak, Roselia Maria Spanevello, Francieli Moro Stefanello. Senolytics prevent age-associated changes in female mice brain. Neuroscience letters. 2024 Mar; 826(?):137730. doi: 10.1016/j.neulet.2024.137730. [PMID: 38485080]
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  • Guangyan Zheng, Wenli Wu, Zemei Liu, Yuanju Lv, Yongming Luo, Xin Che, Lihong Wang. Quercetin nanocrystals prepared using a microfluidic chip with improved in vitro dissolution. Pharmaceutical development and technology. 2024 Mar; 29(3):143-152. doi: 10.1080/10837450.2024.2315444. [PMID: 38353125]
  • Shehab Elbeltagi, Ahmad M Saeedi, Zienab E Eldin, Haifa E Alfassam, Hanan M Alharbi, Nawal Madkhali, Abo Bakr Abdel Shakor, Mohamed Abd El-Aal. Biosynthesis, characterization, magnetic hyperthermia, and in vitro toxicity evaluation of quercetin-loaded magnetoliposome lipid bilayer hybrid system on MCF-7 breast cancer. Biochimica et biophysica acta. General subjects. 2024 Mar; 1868(3):130543. doi: 10.1016/j.bbagen.2023.130543. [PMID: 38103758]
  • Yue Xin, Xueqing Li, Kaixin Ping, Yannan Xiang, Mengxin Li, Xing Li, Haitao Yang, Jingquan Dong. Pesticide avermectin-induced hepatotoxicity and growth inhibition in carp: Ameliorative capacity and potential mechanisms of quercetin as a dietary additive. Aquatic toxicology (Amsterdam, Netherlands). 2024 Mar; 268(?):106859. doi: 10.1016/j.aquatox.2024.106859. [PMID: 38342007]
  • Bianca Papotti, Mattia Dessena, Maria Pia Adorni, Davide Paleari, Laura Rinaldi, Franco Bernini. In vitro evaluation of the immunomodulatory activity of the nutraceutical formulation AminoDefence. International journal of food sciences and nutrition. 2024 Mar; 75(2):173-184. doi: 10.1080/09637486.2023.2283688. [PMID: 38030612]
  • Jiang-Yan Chen, Sheng Guo, Xiao-Xue Xu, Ya Yang, Yue Zhu, Hong-Jie Kang, Jin-Ao Duan. [Comparison of in vivo pharmacokinetics of twelve constituents in Qihe Fenqing Yin in normal rats and diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Mar; 49(5):1378-1387. doi: 10.19540/j.cnki.cjcmm.20231210.201. [PMID: 38621986]
  • Rui Li, Dingtao Wu, Jianping Hu, Yuqi Ma, Yabo Ba, Liang Zou, Yichen Hu. Polyphenol-enriched Penthorum chinense Pursh ameliorates alcohol-related liver injury through Ras/Raf/MEK/ERK pathway: Integrating network pharmacology and experiment validation. Journal of ethnopharmacology. 2024 Mar; 321(?):117513. doi: 10.1016/j.jep.2023.117513. [PMID: 38040131]
  • Xiaomeng Ji, Jiajia Guo, Yeyun Ma, Shuai Zhang, Zuwang Yang, Yuanyuan Li, Kaixin Ping, Yue Xin, Zibo Dong. Quercetin alleviates the toxicity of difenoconazole to the respiratory system of carp by reducing ROS accumulation and maintaining mitochondrial dynamic balance. Toxicology and applied pharmacology. 2024 Mar; 484(?):116860. doi: 10.1016/j.taap.2024.116860. [PMID: 38342444]
  • Qingzhi Wan, Lisha Tang, Kaili Jin, Xuanyi Chen, Yinghuan Li, Xiaofeng Xu. Quercetin and tanshinone prevent mitochondria from oxidation and autophagy to inhibit KGN cell apoptosis through the SIRT1/SIRT3-FOXO3a axis. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Feb; 70(2):257-263. doi: 10.14715/cmb/2024.70.2.36. [PMID: 38430013]
  • Mamoon Ur Rasheed, Syed Ali Raza Naqvi, Fahad Al-Asmari, Muhammad Abdul Rahim, Mohamed Fawzy Ramadan. Phytochemicals, Health-Promoting Effects, and Enzyme Inhibition Traits of Phlomis stewartii Extracts. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051049. [PMID: 38474560]
  • Yang Lu, Xinglong Liu, Ting Zhao, Chuanbo Ding, Qiteng Ding, Ning Wang, Shuang Ma, Lina Ma, Wencong Liu. Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051042. [PMID: 38474556]
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  • Chen-Hui Chen, Yi Yang, Jia-Ping Ke, Zi Yang, Jia-Yi Li, Yu-Xing Zhang, Guangjin Liu, Zhijun Liu, Guangmin Yao, Guan-Hu Bao. Novel Flavonol Alkaloids in Green Tea: Synthesis, Detection, and Anti-Alzheimer's Disease Effect in a Transgenic Caenorhabditis elegans CL4176 Model. Journal of agricultural and food chemistry. 2024 Feb; 72(7):3695-3706. doi: 10.1021/acs.jafc.3c06608. [PMID: 38324412]
  • Lingkun Wang, Yaochen Xie, Boneng Xiao, Xuelin He, Guanghui Ying, Huiyan Zha, Chen Yang, Xuejin Jin, Guilin Li, Li Ping, Jincheng Wang, Qinjie Weng. Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation. Free radical biology & medicine. 2024 Feb; 212(?):22-33. doi: 10.1016/j.freeradbiomed.2023.12.010. [PMID: 38101584]
  • Sergio R Zúñiga-Hernández, Trinidad García-Iglesias, Monserrat Macías-Carballo, Alejandro Pérez-Larios, Yanet Karina Gutiérrez-Mercado, Gabriela Camargo-Hernández, Christian Martin Rodríguez-Razón. Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay. Nutrients. 2024 Feb; 16(4):. doi: 10.3390/nu16040566. [PMID: 38398890]
  • Dehong Mu, Li Zhou, Lingyu Shi, Ting Liu, Ying Guo, Hao Chen, Hongping Luo, Junhao Ma, Hui Zhang, Peizheng Xiong, Li Tian. Quercetin-crosslinked chitosan nanoparticles: a potential treatment for allergic rhinitis. Scientific reports. 2024 02; 14(1):4021. doi: 10.1038/s41598-024-54501-2. [PMID: 38369554]
  • Mengru Xu, Wenwen Zhang, Sheng Xu, Xiaochen Niu, Li Wang, Xiaohui Wang, Haihu Hao. Elucidation of the mechanism of Zhenbao pills for the treatment of spinal cord injury by network pharmacology and molecular docking: A review. Medicine. 2024 Feb; 103(7):e36970. doi: 10.1097/md.0000000000036970. [PMID: 38363936]
  • Maxime Vincent, Jordan Lehoux, Claire Desmarty, Esperance Moine, Philippe Legrand, Christophe Dorandeu, Laurianne Simon, Thierry Durand, Philippe Brabet, Céline Crauste, Sylvie Begu. A novel lipophenol quercetin derivative to prevent macular degeneration: Intravenous and oral formulations for preclinical pharmacological evaluation. International journal of pharmaceutics. 2024 Feb; 651(?):123740. doi: 10.1016/j.ijpharm.2023.123740. [PMID: 38145781]
  • Devika Sonawane, Varsha Pokharkar. Quercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies. AAPS PharmSciTech. 2024 Feb; 25(2):30. doi: 10.1208/s12249-024-02736-7. [PMID: 38316672]
  • Nimra Riasat, Muniba Jadoon, Nosheen Akhtar, Marya Nawaz Kiani, Humaira Fatima, Mostafa A Abdel-Maksoud, Syeda Masooma Ali, Akram A Alfuraydi, M Junaid Dar, Ihsan Ul Haq. Polyphenolic characterization and biological assessment of Acacia nilotica (L.) wild. Ex delilie: An In vitro and In vivo appraisal of wound healing potential. Journal of ethnopharmacology. 2024 Feb; ?(?):117842. doi: 10.1016/j.jep.2024.117842. [PMID: 38310987]
  • Yang Ye, Chen Xiaoyang, Yao Junkai, H U Yueyao, Wang Wei. Efficacy of Danlou tablet on myocardial ischemia/ reperfusion injury assessed by network pharmacology and experimental verification. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):131-144. doi: 10.19852/j.cnki.jtcm.20231121.003. [PMID: 38213248]
  • Jingyun Gao, Yueyue Wang, Hui Xiong, Shengnan Zhao, Mingmei He, Meiting He, Haifeng Pan. Uncovering the Mechanism of Chinese Hawthorn Leaf on Myocardial Ischemia Based on Network Pharmacology, Molecular Docking Verification, and In Vitro Studies. Cardiovascular toxicology. 2024 Feb; 24(2):171-183. doi: 10.1007/s12012-024-09825-w. [PMID: 38376772]
  • Francesco Pettini, Ottavia Spiga, Simone Furini, Fabio Fusi. Electrophysiology, molecular modelling, and functional analysis of the effects of dietary quercetin and flavonoid analogues on Kir6.1 channels in rat stomach fundus smooth muscle. Biochemical pharmacology. 2024 Feb; 220(?):115969. doi: 10.1016/j.bcp.2023.115969. [PMID: 38086489]
  • Cheryl Chung, Stefan Baier, David Julian McClements, Eric Andrew Decker. Stabilization of myoglobin from different species (produced by cellular agriculture) using food-grade natural and synthetic antioxidants. Food research international (Ottawa, Ont.). 2024 Feb; 178(?):113965. doi: 10.1016/j.foodres.2024.113965. [PMID: 38309880]
  • Amanda Medeiros Martins, Camila Rodrigues Adão Malafaia, Rafaela Machado Nunes, Anete Souza Mecenas, Patricia Homobono Britto De Moura, Michele Frazão Muzitano, Thelma de Barros Machado, Carla da Silva Carneiro, Ivana Correa Ramos Leal. Nutritional, chemical and functional potential of Inga laurina (Fabaceae): A barely used edible species. Food research international (Ottawa, Ont.). 2024 Feb; 178(?):113751. doi: 10.1016/j.foodres.2023.113751. [PMID: 38309858]
  • Haixia Zhao, Lijiao Wang, Yujie Jia, Jiali Zhao, Chenglei Li, Hui Chen, Huala Wu, Qi Wu. Accumulation of the bitter substance quercetin mediated by the overexpression of a novel seed-specific gene FtRDE2 in Tartary buckwheat. Plant physiology and biochemistry : PPB. 2024 Feb; 207(?):108402. doi: 10.1016/j.plaphy.2024.108402. [PMID: 38310726]
  • Gan Li, Yiwei Ren, Enmeng Li, Kai Deng, Chao Qu, Junxiang Zhang, Li Zhang, Xingjie Wang, Jie Lian, Huayou Zhou, Zijun Wang, Tianli Shen, Xuqi Li, Zhengdong Jiang. Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/AKT pathway. Journal of ethnopharmacology. 2024 Jan; 319(Pt 2):117242. doi: 10.1016/j.jep.2023.117242. [PMID: 37777024]
  • Valeria Cornelius, Linda Droessler, Salah Amasheh. Quercetin Improves Barrier Properties in Porcine Small Intestine but Not in Peyer's Patches. International journal of molecular sciences. 2024 Jan; 25(3):. doi: 10.3390/ijms25031530. [PMID: 38338808]
  • Annie V Roy, Michael Chan, Logan Banadyga, Shihua He, Wenjun Zhu, Michel Chrétien, Majambu Mbikay. Quercetin inhibits SARS-CoV-2 infection and prevents syncytium formation by cells co-expressing the viral spike protein and human ACE2. Virology journal. 2024 Jan; 21(1):29. doi: 10.1186/s12985-024-02299-w. [PMID: 38273400]
  • Chris Krebs Danilevicz, Lolita Schneider Pizzolato, Sara Elis Bianchi, Gabriela Meirelles, Valquiria Linck Bassani, Ionara Rodrigues Siqueira. Pharmacological evaluation of a traditional Brazilian medicinal plant, Monteverdia ilicifolia. Part I - Preclinical safety study. Journal of ethnopharmacology. 2024 Jan; 324(?):117806. doi: 10.1016/j.jep.2024.117806. [PMID: 38278373]
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  • Caiwang Peng, Qidi Ai, Fengyan Zhao, Hengli Li, Yang Sun, Keyan Tang, Yantao Yang, Naihong Chen, Fang Liu. Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway. European journal of pharmacology. 2024 Jan; 963(?):176264. doi: 10.1016/j.ejphar.2023.176264. [PMID: 38123006]
  • Francisco Flávio da Silva Lopes, Jorge Luís Eloi Silva, Natália de Morais Pereira Eloi, Ana Lívya Moreira Rodrigues, Marcus Vinícius Ferreira da Silva, Renato Almeida Montes, Sara Ingrid Caetano Gomes Barbosa, Daniela Ribeiro Alves, Lucas Soares Frota, Selene Maia Morais. Chemical Characterization, Phenolic Compounds Quantification, and Assessment of Antioxidant and Anti-Acetylcholinesterase Activities of Byrsonima sericea DC fruits. Chemistry & biodiversity. 2024 Jan; ?(?):e202301760. doi: 10.1002/cbdv.202301760. [PMID: 38217459]