Adenosine (BioDeep_00000398007)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

Adenosine

化学式: C10H13N5O4 (267.09674980000005)
中文名称: 腺嘌呤核苷
谱图信息: 最多检出来源 Homo sapiens(blood) 0.08%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)O)O)O
InChI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)

描述信息

COVID info from PDB, Protein Data Bank, COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058913 - Purinergic Agonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C - Cardiovascular system > C01 - Cardiac therapy
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Formula(Parent): C10H13N5O4; Bottle Name:Adenosine; PRIME Parent Name:Adenosine; PRIME in-house No.:0040 R0018, Purines
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; OIRDTQYFTABQOQ_STSL_0143_Adenosine_0500fmol_180430_S2_LC02_MS02_33; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.113
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.109
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.097
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.096
Acquisition and generation of the data is financially supported by the Max-Planck-Society
IPB_RECORD: 2621; CONFIDENCE confident structure
Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].
Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].
Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

同义名列表

4 个代谢物同义名

Adenosine; Ado; Adenine riboside; D-Adenosine

数据库引用编号

95 个数据库交叉引用编号

ChEBI: CHEBI:16335
KEGG: C00212
PubChem: 60961
DrugBank: DB00640
ChEMBL: CHEMBL477
MeSH: Adenosine
CAS: 46946-45-6
CAS: 58-61-7
CAS: 142796-17-6
CAS: 133248-01-8
CAS: 109767-06-8
CAS: 41547-82-4
MoNA: CCMSLIB00000479577
MoNA: CCMSLIB00005464314
MoNA: CCMSLIB00005464315
MoNA: CCMSLIB00005464371
MoNA: CCMSLIB00005720469
MoNA: CCMSLIB00005720762
MoNA: MoNA038592
MoNA: MoNA037930
MoNA: MoNA037212
MoNA: MoNA036138
MoNA: MoNA036137
MoNA: MoNA036136
MoNA: MoNA034202
MoNA: MoNA034198
MoNA: MoNA034196
MoNA: MoNA032234
MoNA: MoNA032232
MoNA: MoNA032231
MoNA: MoNA023982
MoNA: MoNA023946
MoNA: EMBL-MCF_spec59717
MoNA: CCMSLIB00005724006
MoNA: MoNA016656
MoNA: VF-NPL-QTOF006512
MoNA: VF-NPL-QTOF006511
MoNA: VF-NPL-QTOF006510
MoNA: VF-NPL-QTOF006509
MoNA: VF-NPL-QTOF006508
MoNA: VF-NPL-QTOF006507
MoNA: NGA00788
MoNA: NGA00787
MoNA: NGA00786
MoNA: NGA00785
MoNA: MoNA010362
MoNA: MoNA010361
MoNA: MoNA010360
MoNA: MoNA010359
MoNA: MoNA010358
MoNA: MoNA010357
MoNA: MoNA002075
MoNA: MoNA002074
MoNA: MoNA002073
MoNA: VF-NPL-LTQ000178
MoNA: VF-NPL-LTQ000177
MoNA: VF-NPL-QEHF000393
MoNA: VF-NPL-QEHF000392
MoNA: VF-NPL-QEHF000391
MoNA: VF-NPL-QEHF000390
MoNA: VF-NPL-QEHF000389
MoNA: VF-NPL-QEHF000388
MoNA: FiehnHILIC002573
MoNA: FiehnHILIC001738
MoNA: FiehnHILIC001048
MoNA: FiehnHILIC000160
MoNA: HMDB0000050_ms_ms_81
MoNA: HMDB0000050_ms_ms_83
MoNA: HMDB0000050_ms_ms_82
MoNA: PM018194
MoNA: PT200400
MoNA: PT111710
MoNA: PT100403
MoNA: PT100400
MoNA: CCMSLIB00000578272
MoNA: CCMSLIB00000578029
MoNA: BML80693
MoNA: BML80692
MoNA: BML80691
MoNA: BML80690
MoNA: CE000145
MoNA: CE000144
MoNA: CE000143
MoNA: CE000142
MoNA: CE000141
MoNA: PB006011
MoNA: PB006010
MoNA: PB006009
PubChem: 3512
KNApSAcK: C00007444
PDB-CCD: ADN
3DMET: B01189
NIKKAJI: J4.501B
RefMet: Adenosine
medchemexpress: HY-B0228

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

132 个相关的物种来源信息

3055 Chlamydomonas reinhardtii:
76257 Pachliopta aristolochiae: 10.1002/JCCS.200000026
9606 Homo sapiens:
2096 Mycoplasma gallisepticum: 10.1128/MSYSTEMS.00055-17
654 Aeromonas veronii: 10.3389/FCIMB.2020.00044
329779 Solanum incanum:
40716 Paeonia obovata: 10.1248/CPB.48.201
7227 Drosophila melanogaster: 10.1038/S41467-019-11933-Z
5691 Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
354522 Tetradium glabrifolium: 10.1002/JCCS.199500128
34305 Lotus japonicus:
29760 Vitis vinifera: 10.1016/J.DIB.2020.106469
45171 Paeonia suffruticosa: 10.1248/CPB.47.652
28901 Salmonella enterica:
3702 Arabidopsis thaliana:
303 Pseudomonas putida: 10.1371/JOURNAL.PONE.0156509
4530 Oryza sativa: 10.3390/MOLECULES16031917
72228 Ophiocordyceps sinensis:
82528 Crocus sativus:
764175 Glinus oppositifolius: 10.3390/MOLECULES15096186
32046 Synechococcus elongatus: 10.1111/1462-2920.12899
4081 Solanum lycopersicum: 10.1038/SDATA.2014.29
4682 Allium sativum:
4679 Allium cepa:
1142 Synechocystis: 10.1104/PP.108.129403
128687 Phoebe formosana: 10.1002/JCCS.199900034
265230 Oligomeris linifolia: 10.1016/J.BSE.2013.03.020
180039 Psychotria punctata: 10.3389/FMOLB.2021.683671
13345 Ardisia crenata: 10.3389/FMOLB.2021.683671
35525 Daphnia magna: 10.1016/J.ENVINT.2009.12.006
335854 Nigrospora oryzae: 10.1016/J.PHYTOL.2013.09.001
114231 Nigrospora sphaerica: 10.1016/J.PHYTOL.2013.09.001
6669 Daphnia pulex: 10.1038/SREP25125
4896 Schizosaccharomyces pombe: 10.1039/C4MB00346B
81762 Hyacinthoides non-scripta: 10.1038/S41598-019-38940-W
121073 Cassytha filiformis: 10.1021/NP070564H
167137 Neptunea antiqua: 10.1016/0041-0101(89)90038-X
161756 Isatis tinctoria:
4054 Panax ginseng:
681275 Litoria verreauxii: 10.1038/SDATA.2018.33
48119 Glehnia littoralis:
91201 Gastrodia elata: 10.1021/NP0605182
60116 Alangium platanifolium: 10.1016/0031-9422(93)85414-M
1045134 Smilax bracteata: 10.1021/NP010338M
859524 Fritillaria yuminensis: 10.1016/J.BSE.2012.07.002
49576 Torilis japonica: 10.1248/CPB.46.1583
82327 Lilium pumilum: 10.1016/0031-9422(89)80363-2
1218746 Lilium tenuifolium: 10.1016/0031-9422(89)80363-2
48042 Levisticum officinale: 10.1248/YAKUSHI1947.110.10_746
869827 Cucumis sativus var. sativus: 10.1055/S-0028-1088338
3659 Cucumis sativus:
261776 Helichrysum arenarium:
203717 Saposhnikovia divaricata: 10.4268/CJCMM20101214
3498 Morus alba: 10.3390/MOLECULES16076010
170012 Morus alba var. multicaulis: 10.3390/MOLECULES16076010
6501 Aplysia kurodai: 10.1002/JLAC.198819880615
4577 Zea mays: 10.1248/CPB.55.153
4683 Allium tuberosum: 10.1016/S0031-9422(01)00216-3
403120 Strychnos lucida: 10.1007/S11418-005-0021-3
3755 Prunus dulcis: 10.1021/JF020262F
328098 Acanthus ilicifolius:
241842 Acanthus ebracteatus: 10.1016/S0031-9422(01)00306-5
458531 Eurycoma longifolia: 10.1016/J.BMC.2003.11.017
3735 Moringa oleifera: 10.1016/J.PHYTOCHEM.2011.02.021
5599 Alternaria alternata: 10.1007/S10600-010-9662-X
4047 Coriandrum sativum: 10.1248/CPB.51.32
1205701 Brachystemma calycinum: 10.1080/10286020.2011.600250
252316 Junceella juncea: 10.1248/CPB.52.1476
86864 Codonopsis pilosula: 10.1248/CPB.56.1546
23110 Hydrangea macrophylla: 10.3987/COM-09-11886
1049779 Mikania laevigata: 10.1016/J.TETLET.2010.10.102
82321 Lilium mackliniae: 10.1248/CPB.39.2362
48101 Angelica dahurica: 10.1007/BF02973988
44685 Panax japonicus: 10.1080/14786410902999616
46147 Portulaca oleracea: 10.1016/J.PHYTOCHEM.2005.08.011
767284 Subergorgia suberosa:
3711 Brassica rapa: 10.1016/S0031-9422(97)00362-2
2058692 Bryobium eriaeoides: 10.1248/CPB.60.62
97751 Kaempferia parviflora: 10.1248/CPB.60.62
569628 Dioscorea oppositifolia:
55575 Dioscorea polystachya:
1073793 Adiantum philippense: 10.1016/S0031-9422(00)00334-4
172644 Broussonetia papyrifera: 10.1007/S10600-011-0058-3
285508 Streptomyces piomogenus:
51240 Juglans regia: 10.1016/S0031-9422(03)00333-9
41486 Atractylodes lancea: 10.1248/CPB.51.1106
1719624 Oxytropis myriophylla:
124943 Azadirachta indica: 10.1007/S10600-011-0086-Z
3197 Marchantia polymorpha: 10.1016/S0031-9422(00)90522-3
146505 Ilex cornuta: 10.1016/0031-9422(86)80026-7
671264 Oxytropis racemosa: 10.1248/CPB.58.1587
130426 Allium chinense:
269049 Cliona celata: 10.1080/10575639608043233
627609 Cynomorium songaricum:
55307 Tuber indicum: 10.1007/S10600-007-0130-1
2516544 Scaphium affine: 10.1002/CHIN.200338184
54796 Argemone mexicana: 10.1515/ZNC-2003-7-813
45234 Cordyceps: 10.1016/S1572-5995(00)80051-4
55605 Angelica acutiloba: 10.1248/CPB.39.2046
40949 Angelica archangelica: 10.1016/0031-9422(83)83044-1
3879 Medicago sativa: 10.1021/JF000876P
1755145 Gnaphalium polycaulon: 10.1248/CPB.59.1160
52570 Trachyspermum ammi: 10.1248/CPB.49.840
439404 Lactarius subplinthogalus: 10.1080/14786410310001608073
1508160 Ligusticum striatum: 10.1016/0031-9422(95)00524-2
2689076 Ligusticum chuanxiong: 10.1016/0031-9422(95)00524-2
265763 Eleutherococcus giraldii: 10.1016/J.BSE.2012.02.004
357850 Angelica keiskei: 10.1002/HLCA.201500519
7603 Asterias forbesi: 10.1021/NP50070A042
697038 Melicope semecarpifolia: 10.1021/NP50084A014
34190 Hemerocallis fulva:
43335 Populus alba: 10.1016/0031-9422(79)80021-7
3885 Phaseolus vulgaris: 10.1016/S0176-1617(85)80174-7
5315 Ganoderma lucidum:
36072 Ganoderma japonicum: 10.1016/S0021-9673(00)01241-3
43366 Clitoria ternatea: 10.1002/CBER.19681010627
261423 Polygonatum sibiricum: 10.1007/BF02892028
281732 Tethya aurantium: 10.1016/0305-0491(81)90021-3
3120 Ulva pertusa: 10.1002/JPS.2600720827
111616 Ulva australis: 10.1002/JPS.2600720827
449869 Phlebodium decumanum: 10.1055/S-2006-961472
346985 Senna obtusifolia: 10.1007/BF02973951
362788 Senna tora: 10.1007/BF02973951
1144692 Paralepista flaccida: 10.1016/S0040-4039(00)94251-5
600763 Pseudomyrmex triplarinus: 10.1007/BF00924788
8663 Notechis scutatus: 10.1038/180799A0
3656 Cucumis melo: 10.1055/S-0038-1661304
4505 Coix lacryma-jobi: 10.1016/0031-9422(89)80136-0
44588 Panax quinquefolius: 10.1021/NP50050A010
4222 Carthamus tinctorius: 10.1248/YAKUSHI1947.108.11_1101
569774 金线莲: -
4054 Panax Ginseng C. A. Mey.: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Cong Chen, Cai Jiang, Ting Lin, Yue Hu, Huijuan Wu, Qing Xiang, Minguang Yang, Sinuo Wang, Xiao Han, Jing Tao. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise. Acta physiologica (Oxford, England). 2024 Jun; 240(6):e14154. doi: 10.1111/apha.14154. [PMID: 38682314]
Junjie Pan, Fei Tong, Ning Ren, Lanqi Ren, Yibei Yang, Feng Gao, Qiaoping Xu. Role of N6‑methyladenosine in the pathogenesis, diagnosis and treatment of prostate cancer (Review). Oncology reports. 2024 06; 51(6):. doi: 10.3892/or.2024.8747. [PMID: 38757383]
Minggui Song, Jiawen Zhao, Chujun Zhang, Chengchao Jia, Jing Yang, Haonan Zhao, Jingjing Zhai, Beilei Lei, Shiheng Tao, Siqi Chen, Ran Su, Chuang Ma. PEA-m6A: an ensemble learning framework for accurately predicting N6-methyladenosine modifications in plants. Plant physiology. 2024 May; 195(2):1200-1213. doi: 10.1093/plphys/kiae120. [PMID: 38428981]
Yi-Hao Min, Wen-Xuan Shao, Qiu-Shuang Hu, Neng-Bin Xie, Shan Zhang, Yu-Qi Feng, Xi-Wen Xing, Bi-Feng Yuan. Simultaneous Detection of Adenosine-to-Inosine Editing and N6-Methyladenosine at Identical RNA Sites through Deamination-Assisted Reverse Transcription Stalling. Analytical chemistry. 2024 May; 96(21):8730-8739. doi: 10.1021/acs.analchem.4c01022. [PMID: 38743814]
Tian-Long Wang, Xiao-Juan Miao, Yan-Rong Shuai, Hao-Ping Sun, Xiao Wang, Min Yang, Nan Zhang. FAT1 inhibits the proliferation of DLBCL cells via increasing the m6A modification of YAP1 mRNA. Scientific reports. 2024 05; 14(1):11836. doi: 10.1038/s41598-024-62793-7. [PMID: 38782965]
Wanli Ji, Yan Huo, Yifan Zhang, Xiaojing Qian, Yi Ren, Cheng Hu, Jiaqi Zhang. Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis. International immunopharmacology. 2024 May; 132(?):111968. doi: 10.1016/j.intimp.2024.111968. [PMID: 38579565]
Kozue Sakao, Cho Sho, Takeshi Miyata, Kensaku Takara, Rio Oda, De-Xing Hou. Verification of In Vitro Anticancer Activity and Bioactive Compounds in Cordyceps Militaris-Infused Sweet Potato Shochu Spirits. Molecules (Basel, Switzerland). 2024 May; 29(9):. doi: 10.3390/molecules29092119. [PMID: 38731610]
Ye Zhao, Kun-Jin Han, Yan-Ting Tian, Kai-Hua Jia, Yousry A El-Kassaby, Yue Wu, Jie Liu, Hua-Yu Si, Yu-Han Sun, Yun Li. N6-methyladenosine mRNA methylation positively regulated the response of poplar to salt stress. Plant, cell & environment. 2024 May; 47(5):1797-1812. doi: 10.1111/pce.14844. [PMID: 38314665]
Huayue Liu, Mengzhuo Lin, Hui Wang, Xue Li, Die Zhou, Xiaojing Bi, Yunwei Zhang. N6-methyladenosine analysis unveils key mechanisms underlying long-term salt stress tolerance in switchgrass (Panicum virgatum). Plant science : an international journal of experimental plant biology. 2024 May; 342(?):112023. doi: 10.1016/j.plantsci.2024.112023. [PMID: 38320658]
Manman Zhang, Lei Li, Cheng Li, Aifang Ma, Junzhou Li, Chenyu Yang, Xujun Chen, Peng Cao, Shanshan Li, Yanyan Zhang, Zhiguang Yuchi, Xiangge Du, Chongxi Liu, Xiangjing Wang, Xiaodan Wang, Wensheng Xiang. Natural product guvermectin inhibits guanosine 5'-monophosphate synthetase and confers broad-spectrum antibacterial activity. International journal of biological macromolecules. 2024 May; 267(Pt 2):131510. doi: 10.1016/j.ijbiomac.2024.131510. [PMID: 38608989]
Jiyao Liu, Caiqing Zheng, Yuange Duan. New comparative genomic evidence supporting the proteomic diversification role of A-to-I RNA editing in insects. Molecular genetics and genomics : MGG. 2024 Apr; 299(1):46. doi: 10.1007/s00438-024-02141-6. [PMID: 38642133]
Xiu'E Li, Xin Wang, Fengji Liang, Zhaoxin Wang, Wenshuo Liu, Yupeng Ge, Shude Yang, Yu Liu, Yin Li, Xianhao Cheng, Weihuan Li. Biological characteristics of Cordyceps militaris single mating-type strains. Archives of microbiology. 2024 Apr; 206(5):225. doi: 10.1007/s00203-024-03952-2. [PMID: 38642078]
Chongxi Liu, Manman Zhang, Lei Li, Xiangjing Wang, Shanshan Li, Wensheng Xiang. Development and Application of the Novel Plant Growth Regulator Guvermectin: A Perspective. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8365-8371. doi: 10.1021/acs.jafc.3c09704. [PMID: 38588402]
Yaning Wu, Hongwei Zhang, Jianguang Zhu, Zhenling Zhang, Songbo Ma, Yongqi Zhao, Yiming Wang, Jun Yuan, Xing Guo, Yajing Li, Shuai Zhang. The Effect of Fermentation on the Chemical Constituents of Gastrodia Tuber Hallimasch Powder (GTHP) Estimated by UHPLC-Q-Orbitrap HRMS and HPLC. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071663. [PMID: 38611942]
Atcharaporn Ontawong, Sirinat Pengnet, Arthid Thim-Uam, Narongsuk Munkong, Nukrob Narkprasom, Kanjana Narkprasom, Kullanat Kuntakhut, Natakorn Kamkeaw, Doungporn Amornlerdpison. A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Scientific reports. 2024 04; 14(1):7994. doi: 10.1038/s41598-024-58742-z. [PMID: 38580687]
Shuo Li, Xiwen Cui, Yue Cao, Jinsheng Sun. Extracellular ATP- and adenosine-mediated purinergic signaling modulates inducible nitric oxide synthase (iNOS) gene expression, enzyme activity and nitric oxide production in common carp (Cyprinus carpio) head kidney macrophages. Fish & shellfish immunology. 2024 Apr; 147(?):109469. doi: 10.1016/j.fsi.2024.109469. [PMID: 38423488]
Jie Chen, Ziying Guan, Lina Sun, Xinlin Fan, Desen Wang, Xiaoqiang Yu, Lihua Lyu, Guojun Qi. N6-methyladenosine modification of RNA controls dopamine synthesis to influence labour division in ants. Molecular ecology. 2024 Apr; 33(8):e17322. doi: 10.1111/mec.17322. [PMID: 38501589]
Jing-Wen Xu, Si-Qi Tang, Jie Lin, Yu-Jia Li, Dan Shen, Guang-Hong Ding, Xue-Yong Shen, Li-Na Wang. NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at 'Zusanli' (ST36)-induced analgesia in ankle arthritis rats. Brain research bulletin. 2024 Apr; 209(?):110909. doi: 10.1016/j.brainresbull.2024.110909. [PMID: 38402994]
Wei-Wei Liu, Si-Qing Zheng, Tian Li, Yun-Fei Fei, Chen Wang, Shuang Zhang, Fei Wang, Guan-Min Jiang, Hao Wang. RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy. Signal transduction and targeted therapy. 2024 Mar; 9(1):70. doi: 10.1038/s41392-024-01777-5. [PMID: 38531882]
Xiangdong Fan, Yitong Zhang, Ruiying Guo, Kuo Yue, Guy Smagghe, Yongyue Lu, Luoluo Wang. Decoding epitranscriptomic regulation of viral infection: mapping of RNA N6-methyladenosine by advanced sequencing technologies. Cellular & molecular biology letters. 2024 Mar; 29(1):42. doi: 10.1186/s11658-024-00564-y. [PMID: 38539075]
Gang Tu, Xuan Wang, Rong Xia, Bowen Song. m6A-TCPred: a web server to predict tissue-conserved human m6A sites using machine learning approach. BMC bioinformatics. 2024 Mar; 25(1):127. doi: 10.1186/s12859-024-05738-1. [PMID: 38528499]
Zhuyun Bian, Zeyi Wang, Diwen Wang, Jin-Rong Xu. Sexual stage-specific A-to-I mRNA editing is mediated by tRNA-editing enzymes in fungi. Proceedings of the National Academy of Sciences of the United States of America. 2024 Mar; 121(12):e2319235121. doi: 10.1073/pnas.2319235121. [PMID: 38466838]
Yuange Duan, Ling Ma, Jiyao Liu, Xinzhi Liu, Fan Song, Li Tian, Wanzhi Cai, Hu Li. The first A-to-I RNA editome of hemipteran species Coridius chinensis reveals overrepresented recoding and prevalent intron editing in early-diverging insects. Cellular and molecular life sciences : CMLS. 2024 Mar; 81(1):136. doi: 10.1007/s00018-024-05175-6. [PMID: 38478033]
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Christopher Kesten, Valentin Leitner, Susanne Dora, James W Sims, Julian Dindas, Cyril Zipfel, Consuelo M De Moraes, Clara Sanchez-Rodriguez. Soil-borne fungi alter the apoplastic purinergic signaling in plants by deregulating the homeostasis of extracellular ATP and its metabolite adenosine. eLife. 2023 Nov; 12(?):. doi: 10.7554/elife.92913. [PMID: 37994905]
Jidi Xu, Jieqiang He, Bichun Hu, Nan Hou, Junxing Guo, Caixia Wang, Xuewei Li, Zhongxing Li, Jingjing Zhai, Ting Zhang, Chuang Ma, Fengwang Ma, Qingmei Guan. Global hypermethylation of the N6-methyladenosine RNA modification associated with apple heterografting. Plant physiology. 2023 Nov; 193(4):2513-2537. doi: 10.1093/plphys/kiad470. [PMID: 37648253]
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Xiang Cui, Wan Wei, Ziyi Zhang, Kun Liu, Ting Zhao, Jialin Zhang, Ani Zheng, Hanqing Xi, Xun He, Shuya Wang, Bing Zhu, Xinyan Gao. Caffeine impaired acupuncture analgesia in inflammatory pain by blocking adenosine A1 receptor. The journal of pain. 2023 Oct; ?(?):. doi: 10.1016/j.jpain.2023.10.025. [PMID: 37918469]
Zongyi Yi, Yanxia Zhao, Zexuan Yi, Yongjian Zhang, Gangbin Tang, Xiaoxue Zhang, Huixian Tang, Wei Zhang, Ying Zhao, Huayuan Xu, Yuyang Nie, Xueqing Sun, Lijun Xing, Lian Dai, Pengfei Yuan, Wensheng Wei. Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice. Genome biology. 2023 10; 24(1):243. doi: 10.1186/s13059-023-03086-6. [PMID: 37872590]
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Jinhao Chen, Mujie Ye, Jianan Bai, Zhihui Gong, Lijun Yan, Danyang Gu, Chunhua Hu, Feiyu Lu, Ping Yu, Lin Xu, Yan Wang, Ye Tian, Qiyun Tang. ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner. Journal of translational medicine. 2023 10; 21(1):741. doi: 10.1186/s12967-023-04578-6. [PMID: 37858219]
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Yan-Hua Chen, Tao Jiang, Ayinuer Yasen, Bing-Yan Fan, Juan Zhu, Mei-Xian Wang, Xing-Jia Shen. RNA N6-methyladenosine of DHAPAT and PAP involves in regulation of diapause of Bombyx mori via the lipid metabolism pathway. Bulletin of entomological research. 2023 Oct; 113(5):665-675. doi: 10.1017/s0007485323000330. [PMID: 37555240]
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Bin Zhang, Yang Xu, Jinyan Liu, Chongming Wu, Xiaohong Zhao, Lidong Zhou, Yong Xie. Oral Intake of Inosine 5'-Monophosphate in Mice Promotes the Absorption of Exogenous Fatty Acids and Their Conversion into Triglycerides though Enhancing the Phosphorylation of Adenosine 5'-Monophosphate-Activated Protein Kinase in the Liver, Leading to Lipohyperplasia. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914588. [PMID: 37834038]
Linjun Zhou, Weidong Zhou, Yuan Li, Ruifang Hua. m1A Regulatory gene signatures are associated with certain immune cell compositions of the tumor microenvironment and predict survival in kidney renal clear cell carcinoma. European journal of medical research. 2023 Sep; 28(1):321. doi: 10.1186/s40001-023-01292-3. [PMID: 37679761]
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Ting-Ting Liu, Yue-Li Wang, Zhi Zhang, Li-Xin Jia, Jing Zhang, Shuai Zheng, Zhi-Hua Chen, Hua-Hao Shen, Chun-Mei Piao, Jie Du. Abnormal adenosine metabolism of neutrophils inhibits airway inflammation and remodeling in asthma model induced by Aspergillus fumigatus. BMC pulmonary medicine. 2023 Jul; 23(1):258. doi: 10.1186/s12890-023-02553-x. [PMID: 37452319]
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Lu Chen, Ying He, Jinyu Zhu, Shujuan Zhao, Shasha Qi, Xudong Chen, Hao Zhang, Ziheng Ni, Yuan Zhou, Gongxing Chen, Shuiping Liu, Tian Xie. The roles and mechanism of m6A RNA methylation regulators in cancer immunity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114839. doi: 10.1016/j.biopha.2023.114839. [PMID: 37156113]
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Mingxue Zhang, Xiaoqin Dai, Yu Xiang, Linshen Xie, Minghan Sun, Jianyou Shi. Advances in CD73 inhibitors for immunotherapy: Antibodies, synthetic small molecule compounds, and natural compounds. European journal of medicinal chemistry. 2023 Jun; 258(?):115546. doi: 10.1016/j.ejmech.2023.115546. [PMID: 37302340]
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Kequan Fu, Wenbing Chen, Mingzhu Meng, Huimin Zhao, Haoxing Yuan, Yinan Wang, Ying Ren, Yi Yun, Dong Guo. An allosteric modulator of the adenosine A1 receptor potentiates the antilipolytic effect in rat adipose tissue. European journal of pharmacology. 2023 May; 951(?):175777. doi: 10.1016/j.ejphar.2023.175777. [PMID: 37182594]
Xu Wang, Zhipeng Gu, Junyu Wan, Xiong Zhou, Keli Zhu, Xin Wang, Xin Cao, Xixun Yu, Xu Peng, Yong Tang. dECM based dusal-responsive vascular graft with enzyme-controlled adenine release for long-term patency. International journal of biological macromolecules. 2023 May; ?(?):124618. doi: 10.1016/j.ijbiomac.2023.124618. [PMID: 37148948]
Marta Zimna, Jakub Dolata, Zofia Szweykowska-Kulinska, Artur Jarmolowski. The expanding role of RNA modifications in plant RNA polymerase II transcripts: highlights and perspectives. Journal of experimental botany. 2023 Apr; ?(?):. doi: 10.1093/jxb/erad136. [PMID: 37076273]
Brittny N Blakely, John Agnew, Charlotte Gard, Alvaro Romero. Effects of blood meal source on blood consumption and reproductive success of cat fleas, Ctenocephalides felis. PLoS neglected tropical diseases. 2023 04; 17(4):e0011233. doi: 10.1371/journal.pntd.0011233. [PMID: 37053346]
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Wan Wang, Xu Zhao, Yue Ma, Jing Zhang, Cong Xu, Jiage Ma, Muhammad Altaf Hussain, Juncai Hou, Shanshan Qian. Alleviating Effect of Lacticaseibacillus rhamnosus 1.0320 Combined with Dihydromyricetin on Acute Alcohol Exposure-Induced Hepatic Impairment: Based on Short-Chain Fatty Acids and Adenosine 5'-Monophosphate-Activated Protein Kinase-Mediated Lipid Metabolism Signaling Pathway. Journal of agricultural and food chemistry. 2023 Mar; 71(12):4837-4850. doi: 10.1021/acs.jafc.2c08523. [PMID: 36930948]
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Xiao Li, Mengqian Liu, Caihong Dong. Hydrophobin Gene Cmhyd4 Negatively Regulates Fruiting Body Development in Edible Fungi Cordyceps militaris. International journal of molecular sciences. 2023 Feb; 24(5):. doi: 10.3390/ijms24054586. [PMID: 36902017]
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Bing-Rong Li, Yu-Jia Li, Jing-Wen Xu, Meng Huang, Li-Na Wang, Di Zhang, Xue-Yong Shen, Guang-Hong Ding. Mast Cell-Associated Serotonin in Acupoint Contributes to Acupuncture Analgesia in Arthritis Rats by Mediating ATP Release. Frontiers in bioscience (Landmark edition). 2023 01; 28(1):1. doi: 10.31083/j.fbl2801001. [PMID: 36722266]
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