Acacetin (BioDeep_00000267049)

Main id: BioDeep_00000000251

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-

化学式: C16H12O5 (284.0684702)
中文名称: 金合欢素, 刺槐素, 刺槐黄素
谱图信息: 最多检出来源 Homo sapiens(natural_products) 3.17%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(cc2=O)c1ccc(cc1)OC)O)O
InChI: InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3

描述信息

5,7-dihydroxy-4-methoxyflavone is a monomethoxyflavone that is the 4-methyl ether derivative of apigenin. It has a role as an anticonvulsant and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is functionally related to an apigenin. It is a conjugate acid of a 5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate.
Acacetin is a natural product found in Verbascum lychnitis, Odontites viscosus, and other organisms with data available.
A monomethoxyflavone that is the 4-methyl ether derivative of apigenin.
5,7-dihydroxy-2-(4-methoxyphenyl)-4h-chromen-4-one, also known as 4-methoxy-5,7-dihydroxyflavone or acacetin, is a member of the class of compounds known as 4-o-methylated flavonoids. 4-o-methylated flavonoids are flavonoids with methoxy groups attached to the C4 atom of the flavonoid backbone. Thus, 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-chromen-4-one is considered to be a flavonoid lipid molecule. 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-chromen-4-one is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-chromen-4-one can be synthesized from apigenin. 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-chromen-4-one is also a parent compound for other transformation products, including but not limited to, acacetin-7-O-beta-D-galactopyranoside, acacetin-8-C-neohesperidoside, and isoginkgetin. 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-chromen-4-one can be found in ginkgo nuts, orange mint, and winter savory, which makes 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-chromen-4-one a potential biomarker for the consumption of these food products.
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.223
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.225
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].

同义名列表

79 个代谢物同义名

4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-; 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one; 2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-methoxyphenyl)-; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one #; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one; 5-18-04-00575 (Beilstein Handbook Reference); Flavone, 5,7-dihydroxy-4-methoxy-; Flavone,7-dihydroxy-4-methoxy-; 5,7-Dihydroxy-4-methoxyflavone; 4-Methoxy-5,7-dihydroxyflavone; WLN: T66 BO EVJ CR DO1& GQ IQ; Acacetin, analytical standard; DANYIYRPLHHOCZ-UHFFFAOYSA-N; 5,7-Dioxy-4-methoxyflavone; Apigenin 4-dimethyl ether; Acacetin, >=97.0\\% (HPLC); Apigenin 4-methyl ether; APIGENIN-4-METHYL ETHER; Apisenin 4-methyl ether; 4-O-Methylapigenin; Prestwick2_000695; 4-Methoxyapigenin; Prestwick0_000695; Prestwick1_000695; Prestwick3_000695; 4-Methylapigenin; Spectrum5_000930; BCBcMAP01_000082; UNII-KWI7J0A2CC; Buddleoflavonol; 5,7-Dihydroxy-4; ACACETIN [MI]; BPBio1_000935; DivK1c_000878; KBio2_000595; Prestwick_49; KBio2_003163; KBio2_005731; KBio1_000878; IDI1_000878; Linarigenin; Linarisenin; SMP1_000001; KWI7J0A2CC; Acaceztin; Akatsetin; Acacetine; Acacetin; ACAETIN; 5,7-dihydroxy-2-(4-methoxyphenyl)-4-chromenone; 5,7-dihydroxy-2-(4-methoxyphenyl)chromone; Flavone, 5,7-dihydroxy-4-methoxy- (8CI); EINECS 207-552-3; NCGC00095213-02; Spectrum_000135; NCGC00095213-03; NCGC00095213-01; NCGC00016458-01; SPECTRUM200499; KBioSS_000595; BSPBio_000849; ZINC00005600; NINDS_000878; SPBio_002770; CAS-480-44-4; AIDS-014771; BRN 0277879; CHEBI:15335; 00017_FLUKA; AIDS014771; NSC 76061; ST066889; NSC76061; 480-44-4; C01470; 5,7-Dihydroxy-4'-methoxyflavone



数据库引用编号

77 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

312 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Li, Xianmei Zhong, Yueshui Zhao, Jing Shen, Zhangang Xiao, Chalermchai Pilapong. Acacetin inhibited non-small-cell lung cancer (NSCLC) cell growth via upregulating miR-34a in vitro and in vivo. Scientific reports. 2024 01; 14(1):2348. doi: 10.1038/s41598-024-52896-6. [PMID: 38287075]
  • Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J Villar, Felipe Lombó. Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin. Microbial cell factories. 2023 Nov; 22(1):234. doi: 10.1186/s12934-023-02247-3. [PMID: 37964284]
  • Jian-Ping Deng, Xin Liu, Yue Li, Shi-Hao Ni, Shu-Ning Sun, Xiao-Lu Ou-Yang, Xiao-Han Ye, Ling-Jun Wang, Lu Lu. Drug vector representation and potential efficacy prediction based on graph representation learning and transcriptome data: Acacetin from traditional Chinese Medicine model. Journal of ethnopharmacology. 2023 Apr; 305(?):115966. doi: 10.1016/j.jep.2022.115966. [PMID: 36572325]
  • Yanan Zhang, Qianqian Huang, Xiaowei Xiong, Tingting Yin, Sheng Chen, Wanwan Yuan, Guohua Zeng, Qiren Huang. Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway. Journal of physiology and biochemistry. 2023 Feb; ?(?):. doi: 10.1007/s13105-023-00947-3. [PMID: 36781604]
  • Zhe Jiang, Hao Sun, Jiaen Miao, Qiyu Sheng, Jia Xu, Zhe Gao, Xie Zhang, Yufei Song, Kuihao Chen. The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway. Biochemical and biophysical research communications. 2023 01; 640(?):183-191. doi: 10.1016/j.bbrc.2022.12.014. [PMID: 36516527]
  • Mahima Singh, Ajay Guru, Gokul Sudhakaran, Raman Pachaiappan, Shahid Mahboob, K A Al-Ghanim, F Al-Misned, Annie Juliet, Muthukaruppan Gobi, Jesu Arokiaraj. Copper sulfate induced toxicological impact on in-vivo zebrafish larval model protected due to acacetin via anti-inflammatory and glutathione redox mechanism. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Dec; 262(?):109463. doi: 10.1016/j.cbpc.2022.109463. [PMID: 36087706]
  • Jing Mu, Hong Chen, Mengyi Ye, Xiaoxia Zhang, Huisheng Ma. Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway. Journal of cellular and molecular medicine. 2022 08; 26(16):4624-4628. doi: 10.1111/jcmm.17415. [PMID: 35765710]
  • Fei Song, Yi-Jie Mao, Yu Hu, Shan-Shan Zhao, Ruiying Wang, Wei-Yin Wu, Gui-Rong Li, Yan Wang, Gang Li. Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-α/AMPK pathway. European journal of pharmacology. 2022 May; 922(?):174916. doi: 10.1016/j.ejphar.2022.174916. [PMID: 35341782]
  • Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen, Wen-Chung Huang. Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094687. [PMID: 35563076]
  • Guangtao Zhang, Zhaoyan Li, Jiahuan Dong, Weili Zhou, Zhanxia Zhang, Zujun Que, Xiaohong Zhu, Yan Xu, Nida Cao, Aiguang Zhao. Acacetin inhibits invasion, migration and TGF-β1-induced EMT of gastric cancer cells through the PI3K/Akt/Snail pathway. BMC complementary medicine and therapies. 2022 Jan; 22(1):10. doi: 10.1186/s12906-021-03494-w. [PMID: 35000605]
  • Yuan Zhou, Rong Wu, Fei-Fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun, Shi-Bing Su. Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis. Pharmaceutical biology. 2021 Dec; 59(1):1594-1606. doi: 10.1080/13880209.2021.1999275. [PMID: 34808067]
  • Yan Wei, Jianhong Jing, Zhiping Peng, Xiaoqian Liu, Xueyang Wang. Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis. BMC endocrine disorders. 2021 Mar; 21(1):57. doi: 10.1186/s12902-021-00688-8. [PMID: 33781239]
  • Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production. Journal of natural products. 2021 03; 84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121. [PMID: 33667099]
  • Akida Alishir, Jae Sik Yu, Minji Park, Jin-Chul Kim, Changhyun Pang, Jung Kyu Kim, Tae Su Jang, Won Hee Jung, Ki Hyun Kim. Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica. Bioorganic & medicinal chemistry letters. 2021 03; 36(?):127828. doi: 10.1016/j.bmcl.2021.127828. [PMID: 33508466]
  • Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Sin-Ting Ngo, Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu. Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. Journal of natural products. 2021 01; 84(1):1-10. doi: 10.1021/acs.jnatprod.0c00589. [PMID: 33393294]
  • Yao Wu, Fei Song, Yunda Li, Jingzhou Li, Yukai Cui, Yixiang Hong, Weimin Han, Weiyin Wu, Ishan Lakhani, Gang Li, Yan Wang. Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE-/- Mice. Journal of cellular and molecular medicine. 2021 01; 25(1):521-534. doi: 10.1111/jcmm.16106. [PMID: 33241629]
  • Jingyun Jin, Bin Chen, Xiangyang Zhan, Zhiyi Zhou, Hui Liu, Yun Dong. Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-Tang. PloS one. 2021; 16(6):e0252508. doi: 10.1371/journal.pone.0252508. [PMID: 34125845]
  • Xuan Guo, Yin Xu, Hua-Liang Tan, Xiao-Juan Wang, Lin Xiao. The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis. Mediators of inflammation. 2021; 2021(?):5265444. doi: 10.1155/2021/5265444. [PMID: 34594156]
  • Soo-Il Kim, Yun-Ho Kim, Beom Goo Kang, Min-Kyung Kang, Eun-Jung Lee, Dong Yeon Kim, Hyeongjoo Oh, Su Yeon Oh, Woojin Na, Soon Sung Lim, Young-Hee Kang. Linarin and its aglycone acacetin abrogate actin ring formation and focal contact to bone matrix of bone-resorbing osteoclasts through inhibition of αvβ3 integrin and core-linked CD44. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153351. doi: 10.1016/j.phymed.2020.153351. [PMID: 32987362]
  • Young Hye Seo, Tuy An Trinh, Seung Mok Ryu, Hyo Seon Kim, Goya Choi, Byeong Cheol Moon, Sang Hee Shim, Dae Sik Jang, Dongho Lee, Ki Sung Kang, Jun Lee. Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death. Journal of natural products. 2020 10; 83(10):3149-3155. doi: 10.1021/acs.jnatprod.0c00756. [PMID: 32991171]
  • Yunfang Zhou, Yingying Tu, Quan Zhou, Ailian Hua, Peiwu Geng, Feifei Chen, Aixia Han, Jin Liu, Dapeng Dai, Shuanghu Wang, Junlu Wang, Congcong Wen. Evaluation of acacetin inhibition potential against cytochrome P450 in vitro and in vivo. Chemico-biological interactions. 2020 Sep; 329(?):109147. doi: 10.1016/j.cbi.2020.109147. [PMID: 32738202]
  • Eun-Bin Kwon, Myung-Ji Kang, Hyung Won Ryu, Seoghyen Lee, Jae-Won Lee, Mi Kyeong Lee, Hyun-Sun Lee, Su Ui Lee, Sei-Ryang Oh, Mun-Ock Kim. Acacetin enhances glucose uptake through insulin-independent GLUT4 translocation in L6 myotubes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153178. doi: 10.1016/j.phymed.2020.153178. [PMID: 32126492]
  • Vahid Shokri, Cyrus Jalili, Farshid Raissi, Nasim Akhshi, Ali Ghanbari. Evaluating the effects of acacetin versus a low dose of cisplatin drug on male reproductive system and kidney in mice: With emphasis on inflammation process. Andrologia. 2020 Feb; 52(1):e13444. doi: 10.1111/and.13444. [PMID: 31670411]
  • Yunfang Zhou, Ailian Hua, Quan Zhou, Peiwu Geng, Feifei Chen, Lianhe Yan, Shuanghu Wang, Congcong Wen. Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo. Drug design, development and therapy. 2020; 14(?):1909-1919. doi: 10.2147/dddt.s249308. [PMID: 32546958]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Young H Seo, Shin-Young Kang, Ji-Sun Shin, Seung M Ryu, A Y Lee, Goya Choi, Byeong C Moon, Dae-Sik Jang, Sang H Shim, Dongho Lee, Kyung-Tae Lee, Jun Lee. Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages. Journal of natural products. 2019 12; 82(12):3379-3385. doi: 10.1021/acs.jnatprod.9b00697. [PMID: 31747281]
  • Jintuo Yin, Yinling Ma, Caijuan Liang, Jin Gao, Hairong Wang, Lantong Zhang. A Systematic Study of the Metabolites of Dietary Acacetin in Vivo and in Vitro Based on UHPLC-Q-TOF-MS/MS Analysis. Journal of agricultural and food chemistry. 2019 May; 67(19):5530-5543. doi: 10.1021/acs.jafc.9b00330. [PMID: 31025561]
  • Fenglin Sun, Duo Li, Cong Wang, Caixia Peng, Hong Zheng, Xiaofeng Wang. Acacetin-induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor. Phytotherapy research : PTR. 2019 May; 33(5):1551-1561. doi: 10.1002/ptr.6343. [PMID: 31066474]
  • Xin-Yu Liu, Xia Lv, Ping Wang, Chun-Zhi Ai, Qi-Hang Zhou, Moshe Finel, Bin Fan, Yun-Feng Cao, Hui Tang, Guang-Bo Ge. Inhibition of UGT1A1 by natural and synthetic flavonoids. International journal of biological macromolecules. 2019 Apr; 126(?):653-661. doi: 10.1016/j.ijbiomac.2018.12.171. [PMID: 30594625]
  • Narayan D Chaurasiya, Jianping Zhao, Pankaj Pandey, Robert J Doerksen, Ilias Muhammad, Babu L Tekwani. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana). Molecules (Basel, Switzerland). 2019 Feb; 24(4):. doi: 10.3390/molecules24040810. [PMID: 30813423]
  • Qianqian Ma, Yunlong Cui, Siyuan Xu, Yiyao Zhao, Haidan Yuan, Guangchun Piao. Synergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells. Journal of agricultural and food chemistry. 2018 Dec; 66(49):12931-12940. doi: 10.1021/acs.jafc.8b04683. [PMID: 30381943]
  • Erika Gomez-Chang, Guadalupe Vanessa Uribe-Estanislao, Maricruz Martinez-Martinez, Amanda Gálvez-Mariscal, Irma Romero. Anti-Helicobacter pylori Potential of Three Edible Plants Known as Quelites in Mexico. Journal of medicinal food. 2018 Nov; 21(11):1150-1157. doi: 10.1089/jmf.2017.0137. [PMID: 30036109]
  • Lin Liu, Junxia Yang, Beibei Zu, Jingya Wang, Kang Sheng, Lin Zhao, Weiwei Xu. Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice. Scandinavian journal of immunology. 2018 Oct; 88(4):e12712. doi: 10.1111/sji.12712. [PMID: 30176062]
  • Xinchi Feng, Yang Li, Chenxi Guang, Miao Qiao, Tong Wang, Liwei Chai, Feng Qiu. Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. Molecules (Basel, Switzerland). 2018 Aug; 23(9):. doi: 10.3390/molecules23092140. [PMID: 30149616]
  • Huanhuan Ren, Jun Ma, Lingling Si, Boxue Ren, Xiaoyu Chen, Dan Wang, Wenjin Hao, Xuexi Tang, Defang Li, Qiusheng Zheng. Low Dose of Acacetin Promotes Breast Cancer MCF-7 Cells Proliferation Through the Activation of ERK/ PI3K /AKT and Cyclin Signaling Pathway. Recent patents on anti-cancer drug discovery. 2018; 13(3):368-377. doi: 10.2174/1574892813666180420154012. [PMID: 29676234]
  • Nam Young Kim, Hee Souk Kwon, Hyeon Yong Lee. Effect of inhibition on tyrosinase and melanogenesis of Agastache rugosa Kuntze by lactic acid bacteria fermentation. Journal of cosmetic dermatology. 2017 Sep; 16(3):407-415. doi: 10.1111/jocd.12264. [PMID: 27531590]
  • Huangyu Jiang, Jia Yu, Haihui Zheng, Jiamei Chen, Jinjun Wu, Xiaoxiao Qi, Ying Wang, Xinchun Wang, Ming Hu, Lijun Zhu, Zhongqiu Liu. Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides. Pharmaceutical research. 2017 Jul; 34(7):1402-1415. doi: 10.1007/s11095-017-2157-8. [PMID: 28421306]
  • Qisong Zhang, Lijun Zhu, Xia Gong, Yanjiao Ruan, Jia Yu, Huangyu Jiang, Ying Wang, XiaoXiao Qi, Linlin Lu, Zhongqiu Liu. Sulfonation Disposition of Acacetin: In Vitro and in Vivo. Journal of agricultural and food chemistry. 2017 Jun; 65(24):4921-4931. doi: 10.1021/acs.jafc.7b00854. [PMID: 28540728]
  • Rosa Ventura-Martínez, Rodolfo Rodríguez, María Eva González-Trujano, Guadalupe E Ángeles-López, Myrna Déciga-Campos, Claudia Gómez. Spasmogenic and spasmolytic activities of Agastache mexicana ssp. mexicana and A. mexicana ssp. xolocotziana methanolic extracts on the guinea pig ileum. Journal of ethnopharmacology. 2017 Jan; 196(?):58-65. doi: 10.1016/j.jep.2016.12.023. [PMID: 27988399]
  • Reenu Punia, Komal Raina, Rajesh Agarwal, Rana P Singh. Acacetin enhances the therapeutic efficacy of doxorubicin in non-small-cell lung carcinoma cells. PloS one. 2017; 12(8):e0182870. doi: 10.1371/journal.pone.0182870. [PMID: 28859099]
  • Gabriela Ávila-Villarreal, María Eva González-Trujano, Azucena Ibeth Carballo-Villalobos, Berenice Aguilar-Guadarrama, Sara García-Jiménez, Diana Elizabeth Giles-Rivas, Patricia Castillo-España, Rafael Villalobos-Molina, Samuel Estrada-Soto. Anxiolytic-like effects and toxicological studies of Brickellia cavanillesii (Cass.) A. Gray in experimental mice models. Journal of ethnopharmacology. 2016 Nov; 192(?):90-98. doi: 10.1016/j.jep.2016.07.006. [PMID: 27381041]
  • Yuan Zhao, Li Cai, Qiang Sui, Feng Lin, Wen Jiang, Jianli Chen, Weigeng Lu, Qi Gao. Facile synthesis of acacetin and its derivatives. Bioorganic & medicinal chemistry letters. 2016 08; 26(15):3577-80. doi: 10.1016/j.bmcl.2016.06.018. [PMID: 27321812]
  • Ling Fu, Yiqun Sun, Lina Ding, Yangyang Wang, Zhen Gao, Zhen Wu, Shaomin Wang, Wen Li, Yuefeng Bi. Mechanism evaluation of the interactions between flavonoids and bovine serum albumin based on multi-spectroscopy, molecular docking and Q-TOF HR-MS analyses. Food chemistry. 2016 Jul; 203(?):150-157. doi: 10.1016/j.foodchem.2016.01.105. [PMID: 26948600]
  • Hui Liu, Ya-Jing Wang, Lei Yang, Mei Zhou, Man-Wen Jin, Guo-Sheng Xiao, Yan Wang, Hai-Ying Sun, Gui-Rong Li. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Scientific reports. 2016 05; 6(?):25743. doi: 10.1038/srep25743. [PMID: 27160397]
  • Sang-Bum Kim, Taehun Lee, Hun Seok Lee, Chung Kil Song, Hyun-Jong Cho, Dae-Duk Kim, Han-Joo Maeng, In-Soo Yoon. Development and validation of a highly sensitive LC-MS/MS method for the determination of acacetin in human plasma and its application to a protein binding study. Archives of pharmacal research. 2016 Feb; 39(2):213-220. doi: 10.1007/s12272-015-0697-1. [PMID: 26677081]
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