Acacetin (BioDeep_00000000251)

 

Secondary id: BioDeep_00000267049

natural product human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-

化学式: C16H12O5 (284.0685)
中文名称: 刺槐素, 刺槐黄素, 金合欢素
谱图信息: 最多检出来源 Viridiplantae(plant) 12.3%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=CC(OC)=CC=3)=CC(=O)C=2C(O)=C1
InChI: InChI=1/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3

描述信息

5,7-dihydroxy-4-methoxyflavone is a monomethoxyflavone that is the 4-methyl ether derivative of apigenin. It has a role as an anticonvulsant and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is functionally related to an apigenin. It is a conjugate acid of a 5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate.
Acacetin is a natural product found in Verbascum lychnitis, Odontites viscosus, and other organisms with data available.
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].

同义名列表

55 个代谢物同义名

4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-; 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one; 2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-methoxyphenyl)-; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one #; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one; 5-18-04-00575 (Beilstein Handbook Reference); Flavone, 5,7-dihydroxy-4-methoxy-; Flavone,7-dihydroxy-4-methoxy-; 5,7-Dihydroxy-4-methoxyflavone; 4-Methoxy-5,7-dihydroxyflavone; WLN: T66 BO EVJ CR DO1& GQ IQ; Acacetin, analytical standard; DANYIYRPLHHOCZ-UHFFFAOYSA-N; 5,7-Dioxy-4-methoxyflavone; Apigenin 4-dimethyl ether; Acacetin, >=97.0\\% (HPLC); Apigenin 4-methyl ether; APIGENIN-4-METHYL ETHER; Apisenin 4-methyl ether; 4-O-Methylapigenin; Prestwick2_000695; 4-Methoxyapigenin; Prestwick0_000695; Prestwick1_000695; Prestwick3_000695; 4-Methylapigenin; Spectrum5_000930; BCBcMAP01_000082; UNII-KWI7J0A2CC; Buddleoflavonol; 5,7-Dihydroxy-4; ACACETIN [MI]; BPBio1_000935; DivK1c_000878; KBio2_000595; Prestwick_49; KBio2_003163; KBio2_005731; KBio1_000878; IDI1_000878; Linarigenin; Linarisenin; SMP1_000001; KWI7J0A2CC; Acaceztin; Akatsetin; Acacetine; Acacetin; ACAETIN; ACAC; 5,7-Dihydroxy-4'-methoxyflavone; Acacetin



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

516 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 AKT1, BCL2, CASP3, EGFR, MAPK14, MAPK8, MTOR, NFE2L2, PIK3CA, PRKAA2, PTGS2, SIRT1, STAT3, TLR4, TP53, VEGFA
Peripheral membrane protein 2 MTOR, PTGS2
Endosome membrane 2 EGFR, TLR4
Endoplasmic reticulum membrane 5 BCL2, EGFR, HMOX1, MTOR, PTGS2
Nucleus 14 AKT1, BCL2, CASP3, EGFR, HMOX1, MAPK14, MAPK8, MTOR, NFE2L2, PRKAA2, SIRT1, STAT3, TP53, VEGFA
cytosol 13 AKT1, BCL2, CASP3, HMOX1, MAPK14, MAPK8, MTOR, NFE2L2, PIK3CA, PRKAA2, SIRT1, STAT3, TP53
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 2 NFE2L2, TP53
nucleoplasm 11 AKT1, CASP3, HMOX1, MAPK14, MAPK8, MTOR, NFE2L2, PRKAA2, SIRT1, STAT3, TP53
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 4 AKT1, EGFR, TLR4, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 4 EGFR, TLR4, TNF, VEGFA
glutamatergic synapse 4 AKT1, CASP3, EGFR, MAPK14
Golgi apparatus 3 NFE2L2, PRKAA2, VEGFA
Golgi membrane 3 EGFR, INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 7 AKT1, EGFR, NFE2L2, PIK3CA, STAT3, TLR4, TNF
Membrane 9 AKT1, BCL2, EGFR, HMOX1, MTOR, PRKAA2, TLR4, TP53, VEGFA
apical plasma membrane 1 EGFR
axon 2 MAPK8, PRKAA2
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, HMOX1, PTGS2, TP53, VEGFA
extracellular space 6 EGFR, HMOX1, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 4 EGFR, HMOX1, PIK3CA, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, MAPK14, SIRT1, TP53
protein-containing complex 5 AKT1, BCL2, EGFR, PTGS2, TP53
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, TLR4
Secreted 3 IL6, INS, VEGFA
extracellular region 5 IL6, INS, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 2 SIRT1, TP53
Early endosome 1 TLR4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
heterochromatin 1 SIRT1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
spindle 1 AKT1
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
Nucleus, PML body 3 MTOR, SIRT1, TP53
PML body 3 MTOR, SIRT1, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 EGFR, TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 NFE2L2, SIRT1, STAT3, TP53
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
site of double-strand break 1 TP53
fibrillar center 1 SIRT1
nuclear envelope 2 MTOR, SIRT1
Endomembrane system 1 MTOR
endosome lumen 1 INS
cytoplasmic stress granule 1 PRKAA2
euchromatin 1 SIRT1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Jing Li, Xianmei Zhong, Yueshui Zhao, Jing Shen, Zhangang Xiao, Chalermchai Pilapong. Acacetin inhibited non-small-cell lung cancer (NSCLC) cell growth via upregulating miR-34a in vitro and in vivo. Scientific reports. 2024 01; 14(1):2348. doi: 10.1038/s41598-024-52896-6. [PMID: 38287075]
  • Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J Villar, Felipe Lombó. Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin. Microbial cell factories. 2023 Nov; 22(1):234. doi: 10.1186/s12934-023-02247-3. [PMID: 37964284]
  • Jian-Ping Deng, Xin Liu, Yue Li, Shi-Hao Ni, Shu-Ning Sun, Xiao-Lu Ou-Yang, Xiao-Han Ye, Ling-Jun Wang, Lu Lu. Drug vector representation and potential efficacy prediction based on graph representation learning and transcriptome data: Acacetin from traditional Chinese Medicine model. Journal of ethnopharmacology. 2023 Apr; 305(?):115966. doi: 10.1016/j.jep.2022.115966. [PMID: 36572325]
  • Yanan Zhang, Qianqian Huang, Xiaowei Xiong, Tingting Yin, Sheng Chen, Wanwan Yuan, Guohua Zeng, Qiren Huang. Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway. Journal of physiology and biochemistry. 2023 Feb; ?(?):. doi: 10.1007/s13105-023-00947-3. [PMID: 36781604]
  • Zhe Jiang, Hao Sun, Jiaen Miao, Qiyu Sheng, Jia Xu, Zhe Gao, Xie Zhang, Yufei Song, Kuihao Chen. The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway. Biochemical and biophysical research communications. 2023 01; 640(?):183-191. doi: 10.1016/j.bbrc.2022.12.014. [PMID: 36516527]
  • Mahima Singh, Ajay Guru, Gokul Sudhakaran, Raman Pachaiappan, Shahid Mahboob, K A Al-Ghanim, F Al-Misned, Annie Juliet, Muthukaruppan Gobi, Jesu Arokiaraj. Copper sulfate induced toxicological impact on in-vivo zebrafish larval model protected due to acacetin via anti-inflammatory and glutathione redox mechanism. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Dec; 262(?):109463. doi: 10.1016/j.cbpc.2022.109463. [PMID: 36087706]
  • Jing Mu, Hong Chen, Mengyi Ye, Xiaoxia Zhang, Huisheng Ma. Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway. Journal of cellular and molecular medicine. 2022 08; 26(16):4624-4628. doi: 10.1111/jcmm.17415. [PMID: 35765710]
  • Fei Song, Yi-Jie Mao, Yu Hu, Shan-Shan Zhao, Ruiying Wang, Wei-Yin Wu, Gui-Rong Li, Yan Wang, Gang Li. Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-α/AMPK pathway. European journal of pharmacology. 2022 May; 922(?):174916. doi: 10.1016/j.ejphar.2022.174916. [PMID: 35341782]
  • Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen, Wen-Chung Huang. Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094687. [PMID: 35563076]
  • Guangtao Zhang, Zhaoyan Li, Jiahuan Dong, Weili Zhou, Zhanxia Zhang, Zujun Que, Xiaohong Zhu, Yan Xu, Nida Cao, Aiguang Zhao. Acacetin inhibits invasion, migration and TGF-β1-induced EMT of gastric cancer cells through the PI3K/Akt/Snail pathway. BMC complementary medicine and therapies. 2022 Jan; 22(1):10. doi: 10.1186/s12906-021-03494-w. [PMID: 35000605]
  • Yuan Zhou, Rong Wu, Fei-Fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun, Shi-Bing Su. Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis. Pharmaceutical biology. 2021 Dec; 59(1):1594-1606. doi: 10.1080/13880209.2021.1999275. [PMID: 34808067]
  • Yan Wei, Jianhong Jing, Zhiping Peng, Xiaoqian Liu, Xueyang Wang. Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis. BMC endocrine disorders. 2021 Mar; 21(1):57. doi: 10.1186/s12902-021-00688-8. [PMID: 33781239]
  • Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production. Journal of natural products. 2021 03; 84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121. [PMID: 33667099]
  • Akida Alishir, Jae Sik Yu, Minji Park, Jin-Chul Kim, Changhyun Pang, Jung Kyu Kim, Tae Su Jang, Won Hee Jung, Ki Hyun Kim. Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica. Bioorganic & medicinal chemistry letters. 2021 03; 36(?):127828. doi: 10.1016/j.bmcl.2021.127828. [PMID: 33508466]
  • Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Sin-Ting Ngo, Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu. Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. Journal of natural products. 2021 01; 84(1):1-10. doi: 10.1021/acs.jnatprod.0c00589. [PMID: 33393294]
  • Yao Wu, Fei Song, Yunda Li, Jingzhou Li, Yukai Cui, Yixiang Hong, Weimin Han, Weiyin Wu, Ishan Lakhani, Gang Li, Yan Wang. Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE-/- Mice. Journal of cellular and molecular medicine. 2021 01; 25(1):521-534. doi: 10.1111/jcmm.16106. [PMID: 33241629]
  • Jingyun Jin, Bin Chen, Xiangyang Zhan, Zhiyi Zhou, Hui Liu, Yun Dong. Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-Tang. PloS one. 2021; 16(6):e0252508. doi: 10.1371/journal.pone.0252508. [PMID: 34125845]
  • Xuan Guo, Yin Xu, Hua-Liang Tan, Xiao-Juan Wang, Lin Xiao. The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis. Mediators of inflammation. 2021; 2021(?):5265444. doi: 10.1155/2021/5265444. [PMID: 34594156]
  • Soo-Il Kim, Yun-Ho Kim, Beom Goo Kang, Min-Kyung Kang, Eun-Jung Lee, Dong Yeon Kim, Hyeongjoo Oh, Su Yeon Oh, Woojin Na, Soon Sung Lim, Young-Hee Kang. Linarin and its aglycone acacetin abrogate actin ring formation and focal contact to bone matrix of bone-resorbing osteoclasts through inhibition of αvβ3 integrin and core-linked CD44. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153351. doi: 10.1016/j.phymed.2020.153351. [PMID: 32987362]
  • Young Hye Seo, Tuy An Trinh, Seung Mok Ryu, Hyo Seon Kim, Goya Choi, Byeong Cheol Moon, Sang Hee Shim, Dae Sik Jang, Dongho Lee, Ki Sung Kang, Jun Lee. Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death. Journal of natural products. 2020 10; 83(10):3149-3155. doi: 10.1021/acs.jnatprod.0c00756. [PMID: 32991171]
  • Yunfang Zhou, Yingying Tu, Quan Zhou, Ailian Hua, Peiwu Geng, Feifei Chen, Aixia Han, Jin Liu, Dapeng Dai, Shuanghu Wang, Junlu Wang, Congcong Wen. Evaluation of acacetin inhibition potential against cytochrome P450 in vitro and in vivo. Chemico-biological interactions. 2020 Sep; 329(?):109147. doi: 10.1016/j.cbi.2020.109147. [PMID: 32738202]
  • Eun-Bin Kwon, Myung-Ji Kang, Hyung Won Ryu, Seoghyen Lee, Jae-Won Lee, Mi Kyeong Lee, Hyun-Sun Lee, Su Ui Lee, Sei-Ryang Oh, Mun-Ock Kim. Acacetin enhances glucose uptake through insulin-independent GLUT4 translocation in L6 myotubes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153178. doi: 10.1016/j.phymed.2020.153178. [PMID: 32126492]
  • Vahid Shokri, Cyrus Jalili, Farshid Raissi, Nasim Akhshi, Ali Ghanbari. Evaluating the effects of acacetin versus a low dose of cisplatin drug on male reproductive system and kidney in mice: With emphasis on inflammation process. Andrologia. 2020 Feb; 52(1):e13444. doi: 10.1111/and.13444. [PMID: 31670411]
  • Yunfang Zhou, Ailian Hua, Quan Zhou, Peiwu Geng, Feifei Chen, Lianhe Yan, Shuanghu Wang, Congcong Wen. Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo. Drug design, development and therapy. 2020; 14(?):1909-1919. doi: 10.2147/dddt.s249308. [PMID: 32546958]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Young H Seo, Shin-Young Kang, Ji-Sun Shin, Seung M Ryu, A Y Lee, Goya Choi, Byeong C Moon, Dae-Sik Jang, Sang H Shim, Dongho Lee, Kyung-Tae Lee, Jun Lee. Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages. Journal of natural products. 2019 12; 82(12):3379-3385. doi: 10.1021/acs.jnatprod.9b00697. [PMID: 31747281]
  • Jintuo Yin, Yinling Ma, Caijuan Liang, Jin Gao, Hairong Wang, Lantong Zhang. A Systematic Study of the Metabolites of Dietary Acacetin in Vivo and in Vitro Based on UHPLC-Q-TOF-MS/MS Analysis. Journal of agricultural and food chemistry. 2019 May; 67(19):5530-5543. doi: 10.1021/acs.jafc.9b00330. [PMID: 31025561]
  • Fenglin Sun, Duo Li, Cong Wang, Caixia Peng, Hong Zheng, Xiaofeng Wang. Acacetin-induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor. Phytotherapy research : PTR. 2019 May; 33(5):1551-1561. doi: 10.1002/ptr.6343. [PMID: 31066474]
  • Xin-Yu Liu, Xia Lv, Ping Wang, Chun-Zhi Ai, Qi-Hang Zhou, Moshe Finel, Bin Fan, Yun-Feng Cao, Hui Tang, Guang-Bo Ge. Inhibition of UGT1A1 by natural and synthetic flavonoids. International journal of biological macromolecules. 2019 Apr; 126(?):653-661. doi: 10.1016/j.ijbiomac.2018.12.171. [PMID: 30594625]
  • Narayan D Chaurasiya, Jianping Zhao, Pankaj Pandey, Robert J Doerksen, Ilias Muhammad, Babu L Tekwani. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana). Molecules (Basel, Switzerland). 2019 Feb; 24(4):. doi: 10.3390/molecules24040810. [PMID: 30813423]
  • Qianqian Ma, Yunlong Cui, Siyuan Xu, Yiyao Zhao, Haidan Yuan, Guangchun Piao. Synergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells. Journal of agricultural and food chemistry. 2018 Dec; 66(49):12931-12940. doi: 10.1021/acs.jafc.8b04683. [PMID: 30381943]
  • Erika Gomez-Chang, Guadalupe Vanessa Uribe-Estanislao, Maricruz Martinez-Martinez, Amanda Gálvez-Mariscal, Irma Romero. Anti-Helicobacter pylori Potential of Three Edible Plants Known as Quelites in Mexico. Journal of medicinal food. 2018 Nov; 21(11):1150-1157. doi: 10.1089/jmf.2017.0137. [PMID: 30036109]
  • Lin Liu, Junxia Yang, Beibei Zu, Jingya Wang, Kang Sheng, Lin Zhao, Weiwei Xu. Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice. Scandinavian journal of immunology. 2018 Oct; 88(4):e12712. doi: 10.1111/sji.12712. [PMID: 30176062]
  • Xinchi Feng, Yang Li, Chenxi Guang, Miao Qiao, Tong Wang, Liwei Chai, Feng Qiu. Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. Molecules (Basel, Switzerland). 2018 Aug; 23(9):. doi: 10.3390/molecules23092140. [PMID: 30149616]
  • Huanhuan Ren, Jun Ma, Lingling Si, Boxue Ren, Xiaoyu Chen, Dan Wang, Wenjin Hao, Xuexi Tang, Defang Li, Qiusheng Zheng. Low Dose of Acacetin Promotes Breast Cancer MCF-7 Cells Proliferation Through the Activation of ERK/ PI3K /AKT and Cyclin Signaling Pathway. Recent patents on anti-cancer drug discovery. 2018; 13(3):368-377. doi: 10.2174/1574892813666180420154012. [PMID: 29676234]
  • Nam Young Kim, Hee Souk Kwon, Hyeon Yong Lee. Effect of inhibition on tyrosinase and melanogenesis of Agastache rugosa Kuntze by lactic acid bacteria fermentation. Journal of cosmetic dermatology. 2017 Sep; 16(3):407-415. doi: 10.1111/jocd.12264. [PMID: 27531590]
  • Huangyu Jiang, Jia Yu, Haihui Zheng, Jiamei Chen, Jinjun Wu, Xiaoxiao Qi, Ying Wang, Xinchun Wang, Ming Hu, Lijun Zhu, Zhongqiu Liu. Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides. Pharmaceutical research. 2017 Jul; 34(7):1402-1415. doi: 10.1007/s11095-017-2157-8. [PMID: 28421306]
  • Qisong Zhang, Lijun Zhu, Xia Gong, Yanjiao Ruan, Jia Yu, Huangyu Jiang, Ying Wang, XiaoXiao Qi, Linlin Lu, Zhongqiu Liu. Sulfonation Disposition of Acacetin: In Vitro and in Vivo. Journal of agricultural and food chemistry. 2017 Jun; 65(24):4921-4931. doi: 10.1021/acs.jafc.7b00854. [PMID: 28540728]
  • Rosa Ventura-Martínez, Rodolfo Rodríguez, María Eva González-Trujano, Guadalupe E Ángeles-López, Myrna Déciga-Campos, Claudia Gómez. Spasmogenic and spasmolytic activities of Agastache mexicana ssp. mexicana and A. mexicana ssp. xolocotziana methanolic extracts on the guinea pig ileum. Journal of ethnopharmacology. 2017 Jan; 196(?):58-65. doi: 10.1016/j.jep.2016.12.023. [PMID: 27988399]
  • Reenu Punia, Komal Raina, Rajesh Agarwal, Rana P Singh. Acacetin enhances the therapeutic efficacy of doxorubicin in non-small-cell lung carcinoma cells. PloS one. 2017; 12(8):e0182870. doi: 10.1371/journal.pone.0182870. [PMID: 28859099]
  • Gabriela Ávila-Villarreal, María Eva González-Trujano, Azucena Ibeth Carballo-Villalobos, Berenice Aguilar-Guadarrama, Sara García-Jiménez, Diana Elizabeth Giles-Rivas, Patricia Castillo-España, Rafael Villalobos-Molina, Samuel Estrada-Soto. Anxiolytic-like effects and toxicological studies of Brickellia cavanillesii (Cass.) A. Gray in experimental mice models. Journal of ethnopharmacology. 2016 Nov; 192(?):90-98. doi: 10.1016/j.jep.2016.07.006. [PMID: 27381041]
  • Yuan Zhao, Li Cai, Qiang Sui, Feng Lin, Wen Jiang, Jianli Chen, Weigeng Lu, Qi Gao. Facile synthesis of acacetin and its derivatives. Bioorganic & medicinal chemistry letters. 2016 08; 26(15):3577-80. doi: 10.1016/j.bmcl.2016.06.018. [PMID: 27321812]
  • Ling Fu, Yiqun Sun, Lina Ding, Yangyang Wang, Zhen Gao, Zhen Wu, Shaomin Wang, Wen Li, Yuefeng Bi. Mechanism evaluation of the interactions between flavonoids and bovine serum albumin based on multi-spectroscopy, molecular docking and Q-TOF HR-MS analyses. Food chemistry. 2016 Jul; 203(?):150-157. doi: 10.1016/j.foodchem.2016.01.105. [PMID: 26948600]
  • Hui Liu, Ya-Jing Wang, Lei Yang, Mei Zhou, Man-Wen Jin, Guo-Sheng Xiao, Yan Wang, Hai-Ying Sun, Gui-Rong Li. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Scientific reports. 2016 05; 6(?):25743. doi: 10.1038/srep25743. [PMID: 27160397]
  • Sang-Bum Kim, Taehun Lee, Hun Seok Lee, Chung Kil Song, Hyun-Jong Cho, Dae-Duk Kim, Han-Joo Maeng, In-Soo Yoon. Development and validation of a highly sensitive LC-MS/MS method for the determination of acacetin in human plasma and its application to a protein binding study. Archives of pharmacal research. 2016 Feb; 39(2):213-220. doi: 10.1007/s12272-015-0697-1. [PMID: 26677081]
  • Xue Wang, Haribalan Perumalsamy, Hyung Wook Kwon, Young-Eun Na, Young-Joon Ahn. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease. Scientific reports. 2015 Nov; 5(?):16127. doi: 10.1038/srep16127. [PMID: 26530776]
  • Klaokwan Srisook, Ekaruth Srisook, Wenuka Nachaiyo, Mingkwan Chan-In, Jitra Thongbai, Karnjanapa Wongyoo, Sasithorn Chawsuanthong, Kanita Wannasri, Sudarat Intasuwan, Kingkan Watcharanawee. Bioassay-guided isolation and mechanistic action of anti-inflammatory agents from Clerodendrum inerme leaves. Journal of ethnopharmacology. 2015 May; 165(?):94-102. doi: 10.1016/j.jep.2015.02.043. [PMID: 25725433]
  • Qiang Wei, Zhen Qiu, Fei Xu, Qian-rong Li, Hao Yin. [Chemical Components from Leaves of Fatsia japonica and Their Antitumor Activities in vitro]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Apr; 38(4):745-50. doi: . [PMID: 26672339]
  • Li-hua Fan, Xiaoheng Li, De-yuan Chen, Ning Zhang, Yiyan Wang, Yuanyuan Shan, Yuanyuan Hu, Ren-ai Xu, Jian Jin, Ren-Shan Ge. Determination of acacetin in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Apr; 986-987(?):18-22. doi: 10.1016/j.jchromb.2015.01.040. [PMID: 25703948]
  • Krutzkaya Juárez-Reyes, Fernando Brindis, Omar N Medina-Campos, José Pedraza-Chaverri, Robert Bye, Edelmira Linares, Rachel Mata. Hypoglycemic, antihyperglycemic, and antioxidant effects of the edible plant Anoda cristata. Journal of ethnopharmacology. 2015 Feb; 161(?):36-45. doi: 10.1016/j.jep.2014.11.052. [PMID: 25490313]
  • Qiang Wei, Xiao-ying Ji, Xian-shun Long, Qian-rong Li, Hao Yin. [Chemical Constituents from Leaves of "Chuju" Chrysanthemum morifolium and Their Antioxidant Activities in vitro]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Feb; 38(2):305-10. doi: . [PMID: 26415406]
  • Hong-Ik Cho, Jin-Hyun Park, Hyo-Sun Choi, Jong Hwan Kwak, Dong-Ung Lee, Sang Kook Lee, Sun-Mee Lee. Protective mechanisms of acacetin against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice. Journal of natural products. 2014 Nov; 77(11):2497-503. doi: 10.1021/np500537x. [PMID: 25382719]
  • Abdur Rauf, Rehan Khan, Haroon Khan, Barkat Ullah, Samreen Pervez. Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin. BMC complementary and alternative medicine. 2014 Nov; 14(?):448. doi: 10.1186/1472-6882-14-448. [PMID: 25407486]
  • Erdenechimeg Selenge, Toshihiro Murata, Shiho Tanaka, Kenroh Sasaki, Javzan Batkhuu, Fumihiko Yoshizaki. Monoterpene glycosides, phenylpropanoids, and acacetin glycosides from Dracocephalum foetidum. Phytochemistry. 2014 May; 101(?):91-100. doi: 10.1016/j.phytochem.2014.02.007. [PMID: 24582463]
  • Elke H Heiss, Thi Van Anh Tran, Kristin Zimmermann, Stefan Schwaiger, Corina Vouk, Barbara Mayerhofer, Clemens Malainer, Atanas G Atanasov, Hermann Stuppner, Verena M Dirsch. Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata. Journal of natural products. 2014 Mar; 77(3):503-8. doi: 10.1021/np400778m. [PMID: 24476568]
  • Daniela Ribeiro, Marisa Freitas, Sara M Tomé, Artur M S Silva, Graça Porto, Eurico J Cabrita, M Manuel B Marques, Eduarda Fernandes. Inhibition of LOX by flavonoids: a structure-activity relationship study. European journal of medicinal chemistry. 2014 Jan; 72(?):137-45. doi: 10.1016/j.ejmech.2013.11.030. [PMID: 24368208]
  • Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wang. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. PloS one. 2014; 9(2):e88644. doi: 10.1371/journal.pone.0088644. [PMID: 24520409]
  • Nancy Patience Motlalepula Komape, Mutalib Aderogba, Victor Patrick Bagla, Peter Masoko, Jacobus Nicolaas Eloff. Anti-bacterial and anti-oxidant activities of leaf extracts of Combretum vendae (Combretecacea) and the isolation of an anti-bacterial compound. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2014; 11(5):73-7. doi: 10.4314/ajtcam.v11i5.12. [PMID: 25395708]
  • Gui-xia He, Xiao-lan Liang, Wen Ouyang, Gang-qiang Yi, Yun-yao Li, Jian-ping Zhao, Khan Ikhlas. [Chemical constituents from Ajuga nipponensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Dec; 36(12):1950-3. doi: ". [PMID: 25090678]
  • Tariq A Bhat, Dhanya Nambiar, Dhanir Tailor, Arttatrana Pal, Rajesh Agarwal, Rana P Singh. Acacetin inhibits in vitro and in vivo angiogenesis and downregulates Stat signaling and VEGF expression. Cancer prevention research (Philadelphia, Pa.). 2013 Oct; 6(10):1128-39. doi: 10.1158/1940-6207.capr-13-0209. [PMID: 23943785]
  • Naomi Tanigawa, Makoto Hagiwara, Hiroyuki Tada, Toshinori Komatsu, Shinsuke Sugiura, Kaoru Kobayashi, Yoshiko Kato, Naoyuki Ishida, Kyohei Nishida, Masayuki Ninomiya, Mamoru Koketsu, Kenji Matsushita. Acacetin inhibits expression of E-selectin on endothelial cells through regulation of the MAP kinase signaling pathway and activation of NF-κB. Immunopharmacology and immunotoxicology. 2013 Aug; 35(4):471-7. doi: 10.3109/08923973.2013.811596. [PMID: 23855486]
  • Juriyati Jalil, Ibrahim Jantan, Azura Abdul Ghani, Shahnaz Murad. Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens King. Molecules (Basel, Switzerland). 2012 Sep; 17(9):10893-901. doi: 10.3390/molecules170910893. [PMID: 22964504]
  • Jing Sun, Yun Huang, Guibo Sun, Xiaobo Sun, Meng Qin, Ding Zhao. [Study on in vitro antioxidant activity of flavonoids contained in Hebei balmy chrysanthemum and structure-activity relationship]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jul; 37(13):1958-62. doi: . [PMID: 23019878]
  • M Martínez-Vázquez, R Estrada-Reyes, A Martínez-Laurrabaquio, C López-Rubalcava, G Heinze. Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: sedative effect and chemical analysis of an aqueous extract. Journal of ethnopharmacology. 2012 Jun; 141(3):908-17. doi: 10.1016/j.jep.2012.03.028. [PMID: 22469767]
  • Si-Yang Fan, Hua-Wu Zeng, Yue-Hu Pei, Li Li, Ji Ye, Yue-Xin Pan, Ji-Gang Zhang, Xing Yuan, Wei-Dong Zhang. The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. Journal of ethnopharmacology. 2012 Jun; 141(2):647-52. doi: 10.1016/j.jep.2011.05.019. [PMID: 21619922]
  • M T Monforte, F Lanuzza, S Pergolizzi, F Mondello, O Tzakou, E M Galati. Protective effect of Calamintha officinalis Moench leaves against alcohol-induced gastric mucosa injury in rats. Macroscopic, histologic and phytochemical analysis. Phytotherapy research : PTR. 2012 Jun; 26(6):839-44. doi: 10.1002/ptr.3647. [PMID: 22076933]
  • Chuan-shan Jin, De-lin Wu, Nian-jun Yu, Hui-fang Chen, Tong-sheng Wang, Wei Zhang. [The influence of different processing on the content of flavones of Dendranthema morifolium]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 May; 35(5):702-4. doi: ". [PMID: 23213730]
  • María Eva González-Trujano, Rosa Ventura-Martínez, Marco Chávez, Irene Díaz-Reval, Francisco Pellicer. Spasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicana. Planta medica. 2012 May; 78(8):793-6. doi: 10.1055/s-0031-1298416. [PMID: 22473340]
  • François Senejoux, Céline Demougeot, Parhat Kerram, Haji Akber Aisa, Alain Berthelot, Françoise Bévalot, Corine Girard-Thernier. Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae). Fitoterapia. 2012 Mar; 83(2):377-82. doi: 10.1016/j.fitote.2011.11.023. [PMID: 22155596]
  • Vyacheslav V Martemyanov, Ivan M Dubovskiy, Markus J Rantala, Juha-Pekka Salminen, Irina A Belousova, Sergey V Pavlushin, Stanislav A Bakhvalov, Victor V Glupov. The effects of defoliation-induced delayed changes in silver birch foliar chemistry on gypsy moth fitness, immune response, and resistance to baculovirus infection. Journal of chemical ecology. 2012 Mar; 38(3):295-305. doi: 10.1007/s10886-012-0090-1. [PMID: 22396147]
  • Laura Cariddi, Franco Escobar, Carola Sabini, Cristina Torres, Elina Reinoso, Andrea Cristofolini, Laura Comini, Susana Núñez Montoya, Liliana Sabini. Apoptosis and mutagenicity induction by a characterized aqueous extract of Baccharis articulata (Lam.) Pers. (Asteraceae) on normal cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Feb; 50(2):155-61. doi: 10.1016/j.fct.2011.11.002. [PMID: 22107990]
  • Wen-Chung Huang, Chian-Jiun Liou. Dietary acacetin reduces airway hyperresponsiveness and eosinophil infiltration by modulating eotaxin-1 and th2 cytokines in a mouse model of asthma. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):910520. doi: 10.1155/2012/910520. [PMID: 23049614]
  • Jie Feng, Xiuwei Yang. [Constituents from the leaves of Aquilaria sinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jan; 37(2):230-4. doi: . [PMID: 22737857]
  • Jie Zhang, Linxi Li, Xiuhua Liu, Yong Wang, Dongbao Zhao. [Study on chemical constituents of Artemisia sphaerocephala]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jan; 37(2):238-42. doi: . [PMID: 22737859]
  • Hyo Geun Kim, Mi Sun Ju, Sang Keun Ha, Hyangsook Lee, Hyejung Lee, Sun Yeou Kim, Myung Sook Oh. Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. Biological & pharmaceutical bulletin. 2012; 35(8):1287-94. doi: 10.1248/bpb.b12-00127. [PMID: 22863927]
  • Danielle Berrington, Namrita Lall. Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):564927. doi: 10.1155/2012/564927. [PMID: 22649474]
  • Garland More, Namrita Lall, Ahmed Hussein, Thilivhali Emmanuel Tshikalange. Antimicrobial Constituents of Artemisia afra Jacq. ex Willd. against Periodontal Pathogens. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):252758. doi: 10.1155/2012/252758. [PMID: 22693528]
  • Xue-Jing Peng, Chong Li. [Study on the flavanone constitutes of Buddleja davidii]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Oct; 34(10):1534-7. doi: . [PMID: 22372140]
  • Hongbiao Chu, Wenjun He, Yumei Zhang, Changjiu Ji, Ninghua Tan. [Flavonoids and nor-sesquiterpenes of Pedicularis densispica]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Oct; 36(19):2672-5. doi: . [PMID: 22242427]
  • Taha S El-Alfy, Hamida M A El-Gohary, Nadia M Sokkar, Mohammed Hosny, Dalia A Al-Mahdy. A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. Scientia pharmaceutica. 2011 Oct; 79(4):963-75. doi: 10.3797/scipharm.1108-19. [PMID: 22145118]
  • Astrid Obmann, Ingrid Werner, Armin Presser, Martin Zehl, Zita Swoboda, Sodnomtseren Purevsuren, Samdan Narantuya, Christa Kletter, Sabine Glasl. Flavonoid C- and O-glycosides from the Mongolian medicinal plant Dianthus versicolor Fisch. Carbohydrate research. 2011 Sep; 346(13):1868-75. doi: 10.1016/j.carres.2011.04.031. [PMID: 21640336]
  • Sharlene E Sing, Robert K D Peterson. Assessing environmental risks for established invasive weeds: Dalmatian (Linaria dalmatica) and yellow (L. vulgaris) toadflax in North America. International journal of environmental research and public health. 2011 07; 8(7):2828-53. doi: 10.3390/ijerph8072828. [PMID: 21845161]
  • Pascal Wafo, Ramsay S T Kamdem, Zulfiqar Ali, Shazia Anjum, Afshan Begum, Ogbole O Oluyemisi, Shamsun N Khan, Bonaventure T Ngadjui, Xavier F Etoa, Muhammed Iqbal Choudhary. Kaurane-type diterpenoids from Chromoleana odorata, their X-ray diffraction studies and potent α-glucosidase inhibition of 16-kauren-19-oic acid. Fitoterapia. 2011 Jun; 82(4):642-6. doi: 10.1016/j.fitote.2011.02.003. [PMID: 21316426]
  • Taha S El-Alfy, Shahira M Ezzat, Ahmed K Hegazy, Aziza M M Amer, Gehan M Kamel. Isolation of biologically active constituents from Moringa peregrina (Forssk.) Fiori. (family: Moringaceae) growing in Egypt. Pharmacognosy magazine. 2011 Apr; 7(26):109-15. doi: 10.4103/0973-1296.80667. [PMID: 21716619]
  • Sung-Hee Cho, Jeong-Hee Jang, Ji Young Yoon, Chi-Dong Han, Youngsun Choi, Sang-Won Choi. Effects of a safflower tea supplement on antioxidative status and bone markers in postmenopausal women. Nutrition research and practice. 2011 Feb; 5(1):20-7. doi: 10.4162/nrp.2011.5.1.20. [PMID: 21487492]
  • Wafaa A Tawfik, Mona M Abdel-Mohsen, Hany M Radwan, Amira A Habib, M A Yeramian. Phytochemical and biological investigations of Atriplex semibacata R .BR. growing in Egypt. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2011; 8(4):435-43. doi: 10.4314/ajtcam.v8i4.15. [PMID: 22654223]
  • Xiaona Fan, Sheng Lin, Chenggen Zhu, Yang Liu, Jinfeng Hu, Xiaoguang Chen, Wenjie Wang, Naihong Chen, Jiangong Shi. [Aromatic constituents of Heteroplexis micocephal and their bioactivities]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Jan; 36(1):48-56. doi: . [PMID: 21473152]
  • Sajida Abdureyim, Nurmuhammat Amat, Anwar Umar, Halmurat Upur, Benedicte Berke, Nicholas Moore. Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):. doi: 10.1155/2011/725926. [PMID: 20953388]
  • Saeed Samarghandian, Jalil Tavakkol Afshari, Saiedeh Davoodi. Honey induces apoptosis in renal cell carcinoma. Pharmacognosy magazine. 2011 Jan; 7(25):46-52. doi: 10.4103/0973-1296.75901. [PMID: 21472079]
  • Dahai Wang, Zhiqi Yin, Qingwen Zhang, Wencai Ye, Xiaoqi Zhang, Jian Zhang. [Nonvolatile chemical constituents from Pogostemon cablin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Oct; 35(20):2704-7. doi: . [PMID: 21246823]
  • Yunbao Liu, Muraleedharan G Nair. An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Journal of natural products. 2010 Jul; 73(7):1193-5. doi: 10.1021/np1000945. [PMID: 20565070]
  • Qiaofeng Wu, Chenhuan Yu, Yunliang Yan, Jing Chen, Chunchun Zhang, Xinxin Wen. Antiviral flavonoids from Mosla scabra. Fitoterapia. 2010 Jul; 81(5):429-33. doi: 10.1016/j.fitote.2009.12.005. [PMID: 20006976]
  • Yuanhu Zhang, Li He, Huanyu Guan, Jiming Zhang, Xiaosheng Yang. [Flavonoids of Lysimachia paridiformis var. stenophylla]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jul; 35(14):1824-6. doi: 10.4268/cjcmm20101412. [PMID: 20939277]
  • How Y Lai, Yau Y Lim, Kah H Kim. Blechnum orientale Linn - a fern with potential as antioxidant, anticancer and antibacterial agent. BMC complementary and alternative medicine. 2010 Apr; 10(?):15. doi: 10.1186/1472-6882-10-15. [PMID: 20429956]
  • Kristina Beijer, Alexandra Abrahamson, Björn Brunström, Ingvar Brandt. CYP1A inhibition in fish gill filaments: a novel assay applied on pharmaceuticals and other chemicals. Aquatic toxicology (Amsterdam, Netherlands). 2010 Jan; 96(2):145-50. doi: 10.1016/j.aquatox.2009.10.018. [PMID: 19913926]
  • Haijin Shen, Qiaosheng Guo, Hailing Fang, Yanru Wang, Miao Jin. [Determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi Indici by RP-HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jan; 35(2):191-3. doi: 10.4268/cjcmm20100216. [PMID: 20394292]
  • M I Khalil, S A Sulaiman. The potential role of honey and its polyphenols in preventing heart diseases: a review. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2010; 7(4):315-21. doi: 10.4314/ajtcam.v7i4.56693. [PMID: 21731163]
  • Supriya Baikar, Nutan Malpathak. Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. Pharmacognosy reviews. 2010 Jan; 4(7):12-26. doi: 10.4103/0973-7847.65320. [PMID: 22228937]
  • M S Prajapati, J B Patel, K Modi, M B Shah. Leucas aspera: A review. Pharmacognosy reviews. 2010 Jan; 4(7):85-7. doi: 10.4103/0973-7847.65330. [PMID: 22228946]