Betulinic acid (BioDeep_00000000553)
Secondary id: BioDeep_00000173898, BioDeep_00000329505, BioDeep_00000395799, BioDeep_00000859466
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C30H48O3 (456.36032579999994)
中文名称: 香柠檬烯, 白桦酯酸, 白桦酸, 桦木酸, 表白桦脂酸, 白桦脂酸, 表白桦脂酸, 白桦脂酸
谱图信息:
最多检出来源 Viridiplantae(plant) 0.27%
分子结构信息
SMILES: C1[C@@H](C([C@H]2[C@](C1)([C@@H]1[C@@](CC2)([C@]2([C@H](CC1)[C@@H]1[C@@](CC2)(CC[C@H]1C(=C)C)C(=O)O)C)C)C)(C)C)O
InChI: InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23+,24-,27-,28+,29+,30-/m0/s1
描述信息
Betulinic acid is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an anti-HIV agent, an antimalarial, an anti-inflammatory agent, an antineoplastic agent and a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It derives from a hydride of a lupane.
Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome.
Betulinic acid is a natural product found in Ficus auriculata, Gladiolus italicus, and other organisms with data available.
Betulinic Acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal and brain tumor cells.
A lupane-type triterpene derivative of betulin which was originally isolated from BETULA or birch tree. It has anti-inflammatory, anti-HIV and antineoplastic activities.
See also: Jujube fruit (part of); Paeonia lactiflora root (part of).
Betulinic acid is found in abiyuch. Betulinic acid is a naturally occurring pentacyclic triterpenoid which has anti-retroviral, anti-malarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. It is found in the bark of several species of plants, principally the white birch (Betula pubescens) from which it gets its name, but also the Ber tree (Ziziphus mauritiana), the tropical carnivorous plants Triphyophyllum peltatum and Ancistrocladus heyneanus, Diospyros leucomelas a member of the persimmon family, Tetracera boiviniana, the jambul (Syzygium formosanum), flowering quince (Chaenomeles sinensis), Rosemary, and Pulsatilla chinensis. Controversial is a role of p53 in betulinic acid-induced apoptosis. Fulda suggested p53-independent mechanism of the apoptosis, basing on fact of no accumulation of wild-type p53 detected upon treatment with the betulinic acid, whereas wild-type p53 protein strongly increased after treatment with doxorubicin. The suggestion is supported by study of Raisova. On the other hand Rieber suggested that betulinic acid exerts its inhibitory effect on human metastatic melanoma partly by increasing p53
A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
C308 - Immunotherapeutic Agent > C2139 - Immunostimulant
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties[1][2][3][4].
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties[1][2][3][4].
Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity[1].
同义名列表
62 个代谢物同义名
(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylicacid; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid; (1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-17-hydroxy-1,2,14,18,18-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0^{2,10}.0^{5,9}.0^{14,19}]henicosane-5-carboxylic acid; (1R,3 aS,5aR,5bR,7aR,9S,11aR,11bR,13 aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylicacid; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-eicosahydro-cyclopenta[a]chrysene-3a-carboxylic acid; Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3.beta.)-; Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-; (3.BETA.)-3-HYDROXYLUP-20(29)-EN-28-OIC ACID; (3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid; (+)-(3?)-3-Hydroxylup-20(29)-en-28-oic acid; 3-Hydroxy-(3beta)-Lup-20(29)-en-28-oic acid; Lup-20(29)-en-28-oic acid, 3beta -hydroxy-; (3beta)-3-hydroxylup-20(29)-en-28-oic acid; Lup-20(29)-en-28-oic acid, 3beta-hydroxy-; 3beta-Hydroxy-20(29)-lupaene-28-oic acid; (3β)-3-Hydroxylup-20(29)-en-28-oic acid; 3beta-Hydroxy-lup-20(29)-en-28-oic acid; 3beta-hydroxylup-20(29)-en-28-oic acid; Betulinic acid, technical grade, 90\\%; 3β-Hydroxylup-20(29)-en-28-oic acid; Betulinic acid, analytical standard; 3-Hydroxy-lup-20(29)-en-28-oic Acid; 3-hydroxylup-20(29)-en-28-oic acid; Betulinic acid, >=98\\% (HPLC); QGJZLNKBHJESQX-FZFNOLFKSA-N; Lupatic acid;Betulic acid; BETULINIC ACID [INCI]; .beta.-betulinic acid; 3-epi-betulinic acid; 3 Epi betulinic Acid; beta-betulinic acid; BETULINIC ACID [MI]; (+)-Betulinic acid; Betulinic Acid, 24; Prestwick3_000417; Prestwick2_000417; Prestwick1_000417; Prestwick0_000417; β-Betulinic acid; Platanolic acid; UNII-4G6A18707N; betulinic-acid; betulinic acid; Betulinicacid; BPBio1_000412; betulic acid; Lupatic Acid; Prestwick_95; SMP2_000205; Gratiolone; 4G6A18707N; Betulinate; Melaleucin; C30H48O3; Platanol; RL9-080; Mairin; 06L; Epibetulinic acid
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:3087
- KEGG: C08619
- PubChem: 64971
- PubChem: 2371
- HMDB: HMDB0030094
- Metlin: METLIN44088
- DrugBank: DB12480
- ChEMBL: CHEMBL269277
- Wikipedia: Betulinic_acid
- LipidMAPS: LMPR0106140004
- MeSH: Betulinic Acid
- ChemIDplus: 0000472151
- MetaCyc: CPD-14493
- KNApSAcK: C00003741
- KNApSAcK: C00034390
- chemspider: 58496
- CAS: 472-15-1
- CAS: 38736-77-5
- medchemexpress: HY-10529
- PMhub: MS000012909
- MetaboLights: MTBLC3087
- PubChem: 10812
- PDB-CCD: 06L
- 3DMET: B02273
- NIKKAJI: J11.885K
- RefMet: Betulinic acid
- medchemexpress: HY-N0223
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
65 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(65)
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + betulinic aldehyde ⟶ H+ + H2O + an oxidized [NADPH-hemoprotein reductase] + betulinate
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + betulin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulinic aldehyde
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + lupeol ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + betulin
- betulinate biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + betulinic aldehyde ⟶ H+ + H2O + an oxidized [NADPH-hemoprotein reductase] + betulinate
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
857 个相关的物种来源信息
- 429709 Tabebuia rosea: 10.21608/BFSA.1987.74392
- 148671 Anadenanthera colubrina: 10.1055/S-2004-818920
- 237931 Viburnum cylindricum: 10.1002/HLCA.200800420
- 60117 Cornus capitata: 10.1021/NP50046A034
- 912968 Calliandra haematocephala: 10.4314/NJNPM.V3I1.11761
- 159976 Viscum coloratum: 10.1248/CPB.54.1063
- 798610 Terminalia superba: 10.1016/J.PHYTOCHEM.2007.02.020
- 211701 Clusia columnaris: 10.1590/S0102-695X2008000100003
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 170354 Crossopteryx febrifuga: 10.1055/S-2006-962425
- 943723 Oedera genistifolia: 10.1016/0031-9422(90)80181-F
- 112393 Oedera fruticosa: 10.1016/0031-9422(90)80181-F
- 496644 Oedera calycina: 10.1016/0031-9422(90)80181-F
- 39354 Salvia abrotanoides: 10.1055/S-2006-951766
- 714518 Ziziphus jujuba var. spinosa: 10.1111/J.1744-7909.2005.00060.X
- 326968 Ziziphus jujuba:
- 701534 Lespedeza davidii: 10.4268/CJCMM20100813
- 1367312 Diospyros nigra: 10.1002/CHIN.200307143
- 361442 Vitex negundo: 10.1002/PTR.1088
- 231905 Garcinia dulcis: 10.1016/J.PHYTOCHEM.2005.06.025
- 210378 Hypericum ascyron: 10.1016/S0031-9422(99)00412-4
- 210348 Brucea javanica: 10.1002/JCCS.200500117
- 85246 Plumeria obtusa:
- 52847 Plumeria: 10.1201/9780203022320.CH4
- 164936 Melaleuca leucadendra:
- 714511 Tadehagi triquetrum: 10.1021/JF0483117
- 334497 Syzygium sandwicense: 10.1016/S0031-9422(01)00180-7
- 282553 Hypericum sampsonii: 10.1002/CHIN.200451186
- 190244 Helicteres angustifolia: 10.1016/J.PHYTOCHEM.2006.03.005
- 180924 Clusia nemorosa: 10.1016/S0031-9422(97)00746-2
- 458696 Tripterygium wilfordii: 10.1055/S-0029-1241017
- 570484 Diospyros ebenum:
- 1284871 Cassinia laevis: 10.1016/0031-9422(88)83027-9
- 667327 Calophyllum gracilipes: 10.1016/S0040-4039(97)01032-0
- 1924228 Terminalia glabrescens: 10.1590/S0103-50532003000300021
- 61143 Ceriops tagal:
- 3806 Bauhinia purpurea: 10.1002/JCCS.200200042
- 397169 Pouteria torta: 10.1021/NP50009A016
- 198795 Vismia baccifera: 10.1016/S0031-9422(00)95279-8
- 1382013 Helicteres isora: 10.26510/2394-0859.PBE.2017.07
- 556514 Lespedeza bicolor: 10.1016/J.FITOTE.2003.07.012
- 212239 Hypericum patulum: 10.3109/13880209109082884
- 62097 Plumeria rubra: 10.1055/S-0029-1240611
- 372738 Gustavia hexapetala:
- 162908 Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
- 312566 Cuphea carthagenensis: 10.1055/S-2006-959585
- 312572 Cuphea epilobiifolia: 10.1055/S-2006-959585
- 312560 Cuphea appendiculata: 10.1055/S-2006-959585
- 204151 Orthosiphon aristatus: 10.1248/CPB.48.1711
- 126418 Forsythia suspensa: 10.1055/S-1999-14093
- 542674 Phyla dulcis: 10.1021/NP068010M
- 247899 Inga punctata: 10.1021/NP50005A010
- 511531 Peperomia leptostachya: 10.1016/S0031-9422(03)00183-3
- 1719525 Peperomia humilis: 10.1016/S0031-9422(03)00183-3
- 1504171 Doliocarpus dentatus:
- 37690 Citrus trifoliata: 10.1248/CPB.58.971
- 751816 Clinopodium umbrosum: 10.1002/JCCS.199300014
- 424903 Osmanthus armatus: 10.1080/14786410802689713
- 999598 Vismia guianensis: 10.1021/NP990226J
- 268842 Diospyros mollis: 10.1055/S-0028-1099558
- 123495 Hymenopus heteromorphus:
- 54785 Ceanothus velutinus: 10.1016/S0031-9422(00)97178-4
- 1948899 Diospyros melanoxylon:
- 219860 Syzygium claviflorum:
- 107827 Ternstroemia gymnanthera:
- 28501 Cornus kousa: 10.1007/S10600-010-9550-4
- 4146 Olea europaea: 10.1248/CPB.55.784
- 210383 Paliurus hemsleyanus: 10.1016/S0031-9422(97)00313-0
- 137457 Sanguisorba officinalis: 10.1016/S0031-9422(00)97552-6
- 497234 Hedyotis lawsoniae: 10.1248/CPB.32.3906
- 36622 Chaenomeles sinensis: 10.1248/CPB.51.1318
- 237596 Rosa davurica: 10.1248/CPB.37.2232
- 1009471 Ficus pandurata: 10.1080/14786410902757899
- 3498 Morus alba:
- 264981 Ziziphus spina-christi:
- 22987 Moquilea tomentosa:
- 74647 Rosa multiflora: 10.4268/CJCMM20161216
- 1272984 Moquilea pyrifolia: 10.1021/NP960134J
- 39350 Ocimum basilicum:
- 1009467 Diospyros eriantha:
- 684760 Hypericum monogynum: 10.1021/NP1004483
- 1692142 Hypericum chinense: 10.1021/NP1004483
- 282542 Hypericum japonicum: 10.1021/NP1004483
- 271749 Cratoxylum cochinchinense: 10.1021/NP1004483
- 66392 Morus australis: 10.1021/NP970186O
- 248361 Morus indica: 10.1021/NP970186O
- 170012 Morus alba var. multicaulis: 10.3390/MOLECULES16076010
- 241921 Sorocea bonplandii: 10.3987/COM-91-5703
- 296042 Breynia fruticosa: 10.1021/NP2000914
- 252459 Eysenhardtia platycarpa: 10.1021/NP060166Z
- 211974 Berberis koreana: 10.1016/J.BMCL.2010.01.156
- 191885 Biancaea decapetala: 10.1016/0031-9422(92)83658-L
- 512270 Mimosa diplotricha: 10.1021/NP200307R
- 58305 Ilex macropoda: 10.1007/BF02976931
- 381101 Senegalia mellifera: 10.1016/J.PHYTOCHEM.2004.03.002
- 78630 Betula platyphylla: 10.1248/CPB.44.1033
- 216994 Betula lenta: 10.1515/HFSG.1991.45.4.265
- 1009589 Salacia chinensis: 10.1016/J.TET.2008.05.054
- 39358 Prunella vulgaris:
- 63479 Nerium oleander:
- 54221 Clerodendrum mandarinorum: 10.1055/S-2006-957923
- 49220 Salvia verticillata: 10.1021/NP50036A047
- 54211 Clerodendrum bungei: 10.1080/1028602021000000053
- 21880 Salvia:
- 2516474 Cratoxylum sumatranum: 10.1021/NP010395F
- 1333928 Euphorbia micractina: 10.1021/NP900305J
- 276778 Ficus sarmentosa var. thunbergii: 10.1248/CPB.42.608
- 216992 Betula ermanii:
- 1312768 Alphitonia whitei:
- 106658 Alphitonia excelsa:
- 1312767 Alphitonia petriei:
- 262931 Discaria americana: 10.1016/S0031-9422(00)97179-6
- 157914 Ziziphus mauritiana:
- 345801 Paliurus ramosissimus: 10.1016/S0031-9422(01)00234-5
- 138525 Albizia versicolor: 10.1016/S0367-326X(00)00259-8
- 1603837 Strobilanthes dimorphotricha: 10.1055/S-2005-873125
- 346985 Senna obtusifolia:
- 1688492 Aegiphila verticillata: 10.1002/MRC.1236
- 92927 Sarcandra glabra: 10.1016/0031-9422(96)00352-4
- 56065 Pongamia pinnata:
- 413762 Diospyros montana: 10.1016/S0031-9422(97)01020-0
- 413723 Diospyros bipindensis: 10.1016/S0031-9422(97)01020-0
- 1317788 Diospyros hoyleana:
- 55363 Diospyros lotus:
- 413732 Diospyros consolatae: 10.1016/S0031-9422(97)01020-0
- 413745 Diospyros fragrans:
- 2945278 Diospyros canaliculata:
- 2708802 Diospyros chevalieri:
- 413754 Diospyros maingayi:
- 570490 Diospyros monbuttensis:
- 413758 Diospyros maritima:
- 13493 Diospyros virginiana:
- 2708805 Diospyros cinnabarina:
- 1317787 Diospyros gracilescens:
- 413749 Diospyros guianensis: 10.1016/S0031-9422(97)01020-0
- 2945281 Diospyros elliptifolia: 10.1016/S0031-9422(97)01020-0
- 2708808 Diospyros kamerunensis:
- 570493 Diospyros sanza-minika:
- 227309 Diospyros ehretioides: 10.1016/S0031-9422(97)01020-0
- 413755 Diospyros malabarica: 10.1016/S0031-9422(97)01020-0
- 2945273 Diospyros albiflora: 10.1016/S0031-9422(97)01020-0
- 2945279 Diospyros candolleana: 10.1016/S0031-9422(97)01020-0
- 35925 Diospyros kaki: 10.1016/S0031-9422(97)01020-0
- 413728 Diospyros cauliflora: 10.1016/S0031-9422(97)01020-0
- 983402 Diospyros argentea:
- 268846 Diospyros sumatrana:
- 2945305 Diospyros thwaitesii: 10.1016/S0031-9422(97)01020-0
- 413718 Diospyros abyssinica:
- 1008904 Diospyros morrisiana: 10.1016/S0031-9422(97)01020-0
- 268838 Diospyros discolor:
- 1932074 Diospyros blancoi:
- 413760 Diospyros mespiliformis:
- 570487 Diospyros iturensis:
- 413727 Diospyros castanea: 10.1016/S0031-9422(97)01020-0
- 1317786 Diospyros gabunensis:
- 413763 Diospyros natalensis: 10.1016/S0031-9422(97)01020-0
- 413735 Diospyros curranii: 10.1016/S0031-9422(97)01020-0
- 413757 Diospyros mannii:
- 1317789 Diospyros obliquifolia: 10.1016/S0031-9422(97)01020-0
- 1237540 Diospyros verrucosa:
- 570481 Diospyros dendo:
- 2945307 Diospyros walkeri: 10.1016/S0031-9422(97)01020-0
- 589132 Diospyros wallichii:
- 413738 Diospyros diepenhorstii: 10.1016/S0031-9422(97)01020-0
- 570480 Diospyros crassiflora:
- 240001 Diospyros ferrea: 10.1016/S0031-9422(97)01020-0
- 570498 Diospyros zenkeri:
- 1938276 Diospyros siderophylla: 10.1016/S0031-9422(97)01020-0
- 589111 Diospyros buxifolia: 10.1016/S0031-9422(97)01020-0
- 1367301 Diospyros greenwayi: 10.1016/S0031-9422(97)01020-0
- 1367309 Diospyros leucomelas:
- 1937628 Tovomita brevistaminea: 10.1016/S0031-9422(99)00274-5
- 1569406 Eremanthus veadeiroensis: 10.1016/S0305-1978(02)00027-3
- 296037 Phyllanthus reticulatus: 10.1016/S0031-9422(00)94448-0
- 1609897 Syzygium formosanum: 10.1021/NP980313W
- 13427 Cichorium intybus: 10.1021/NP800001V
- 310427 Jasminum lanceolarium: 10.1248/CPB.55.474
- 340447 Vatica diospyroides: 10.1021/JO9902087
- 765745 Sorbus decora: 10.1021/NP1003005
- 295139 Leptospermum scoparium: 10.1002/ARDP.19963291005
- 860794 Hypericum geminiflorum: 10.1016/S0031-9422(96)00644-9
- 84005 Arbutus unedo:
- 496609 Cyclolepis genistoides: 10.1016/S0031-9422(97)00021-6
- 73757 Melaleuca ericifolia: 10.1021/NP800360A
- 1089417 Microtropis fokienensis: 10.1021/NP800093A
- 1609888 Perrottetia arisanensis: 10.1021/NP800093A
- 867530 Stenocereus eruca: 10.1021/NP970364D
- 1325988 Ixeridium gracile: 10.1007/S10600-008-9078-Z
- 45171 Paeonia suffruticosa:
- 2039553 Salvia xalapensis:
- 2569965 Stemodia foliosa: 10.1021/NP800106X
- 62886 Paeonia rockii: 10.1021/NP200359V
- 1007786 Gladiolus italicus: 10.1007/S13369-010-0015-7
- 709061 Artocarpus rigidus: 10.1021/NP1002065
- 228354 Tephrosia purpurea:
- 3956 Combretum indicum: 10.1007/BF02976955
- 66386 Ficus pumila: 10.1248/CPB.46.1647
- 2708779 Cussonia bancoensis: 10.1021/NP020412G
- 198768 Harungana madagascariensis:
- 1679376 Dichapetalum gelonioides: 10.1021/NP058083Q
- 211500 Betula maximowicziana: 10.1007/BF00599285
- 109063 Alnus japonica: 10.1016/0031-9422(81)83035-X
- 2862098 Stemodia trifoliata: 10.1002/MRC.2597
- 158927 Calophyllum inophyllum: 10.2174/157017811796064430
- 210380 Mesua ferrea:
- 169244 Dillenia philippinensis: 10.1248/CPB.59.397
- 489987 Gymnosporia cassinoides: 10.1016/0031-9422(90)85192-I
- 2822244 Maytenus canariensis: 10.1016/0031-9422(90)85192-I
- 2029442 Vatica harmandiana: 10.1021/NP020379Y
- 35924 Paeonia lactiflora:
- 368785 Koompassia malaccensis: 10.1248/CPB.44.2249
- 1157099 Enkianthus cernuus: 10.1016/0031-9422(83)80162-9
- 41788 Stauntonia hexaphylla: 10.1016/S0031-9422(97)00588-8
- 2321275 Coussarea paniculata: 10.1021/NP0204848
- 1856781 Couepia polyandra: 10.1021/NP0301893
- 13715 Tetracentron sinense: 10.1016/S0031-9422(99)00457-4
- 68527 Aegle marmelos: 10.1080/14786410310001608037
- 1874238 Mosla dianthera: 10.1248/CPB.47.1152
- 2026502 Salvia longistyla: 10.1016/0031-9422(84)83092-7
- 34316 Eucalyptus camaldulensis:
- 107240 Scoparia dulcis:
- 413731 Diospyros celebica: 10.1039/P19860000675
- 378027 Ficus polita: 10.3998/ARK.5550190.0011.227
- 41396 Tectona grandis:
- 39331 Lavandula latifolia: 10.1016/0031-9422(92)80309-3
- 3972 Viscum album: 10.1248/CPB.35.3292
- 2268751 Tovomita fructipendula: 10.1016/S0031-9422(00)00296-X
- 1937627 Tovomita brasiliensis: 10.1016/S0031-9422(00)00296-X
- 450057 Swartzia arborescens: 10.3987/COM-95-7249
- 378017 Ficus conraui: 10.1002/HLCA.201100173
- 13523 Euptelea polyandra:
- 66629 Fagonia indica: 10.1016/S0031-9422(98)00750-X
- 211713 Clusia paralicola: 10.3987/COM-01-S(K)67
- 271748 Cratoxylum arborescens: 10.1055/S-2006-951725
- 3755 Prunus dulcis:
- 49169 Rhododendron ovatum: 10.4268/CJCMM20130315
- 284673 Betula alnoides:
- 4270 Byrsonima crassifolia: 10.3109/13880209509088143
- 142522 Harpalyce brasiliana:
- 999597 Hypericum fauriei: 10.1007/BF00598324
- 268905 Salvia farinacea: 10.21779/2542-0321-2016-31-2-51-53
- 204129 Mesosphaerum suaveolens: 10.1016/0031-9422(83)80163-0
- 39367 Salvia rosmarinus:
- 980664 Lepechinia caulescens: 10.1016/S0031-9422(00)89540-0
- 2652355 Buxus wallichiana: 10.1016/S0031-9422(00)86539-5
- 212141 Fagus taurica: 10.1007/978-1-4615-4913-0_23
- 268843 Diospyros rhodocalyx: 10.1055/S-2006-958085
- 23211 Pyrus communis: 10.4268/CJCMM20131917
- 1266558 Origanum compactum: 10.1055/S-2006-962358
- 260145 Ugni molinae: 10.1016/J.BMC.2006.04.021
- 392697 Salvia thymoides: 10.1016/S0031-9422(97)80021-0
- 947117 Valeriana laxiflora: 10.1055/S-2004-827149
- 279240 Marila laxiflora: 10.1076/PHBI.36.2.103.4603
- 204131 Isodon coetsa: 10.1016/0031-9422(93)80051-S
- 3490 Artocarpus integer: 10.1016/S0031-9422(00)90605-8
- 3489 Artocarpus heterophyllus: 10.1016/S0031-9422(00)90605-8
- 1868807 Couepia ulei: 10.1007/BF02980101
- 237951 Viburnum odoratissimum: 10.1002/HLCA.200390068
- 48247 Retanilla trinervia: 10.1002/(SICI)1099-1573(199711)11:7<504::AID-PTR145>3.0.CO;2-O
- 74645 Rosa rugosa: 10.1016/J.BMCL.2013.12.098
- 1233750 Gardenia saxatilis: 10.1016/S0378-8741(03)00261-7
- 141189 Woodfordia fruticosa: 10.1055/S-0028-1097262
- 3258 Equisetum arvense: 10.1016/0031-9422(73)80050-0
- 448037 Clematoclethra scandens: 10.1007/S10600-013-0614-0
- 53205 Ilex latifolia: 10.3329/DUJPS.V3I1.189
- 49619 Rhododendron anthopogon: 10.1007/S10600-013-0640-Y
- 986201 Condea albida: 10.1021/NP50067A028
- 578549 Terminalia brachystemma: 10.1016/J.FITOTE.2009.05.006
- 1720382 Lycopus asper:
- 516551 Lycopus lucidus:
- 16922 Camptotheca acuminata: 10.1002/JCCS.198500029
- 1608024 Dialium excelsum: 10.1515/ZNB-2011-0610
- 1602062 Goniothalamus thwaitesii: 10.1016/S0031-9422(00)00346-0
- 403115 Rauvolfia vomitoria: 10.1007/S10600-011-9944-Y
- 1042139 Syzygium grande: 10.1002/MRC.1954
- 51240 Juglans regia:
- 1871529 Tephrosia angustissima: 10.1055/S-2006-962679
- 271746 Calophyllum macrocarpum: 10.1016/S0031-9422(00)84521-5
- 2268749 Tovomita choisyana: 10.1016/S0031-9422(00)80565-8
- 486170 Luxemburgia octandra: 10.1590/S0103-50532004000100023
- 883786 Henriettea fascicularis: 10.1021/NP0201164
- 1288024 Terminalia elliptica: 10.1021/NP50045A039
- 1489821 Terminalia alata: 10.1021/NP50045A039
- 172200 Terminalia arjuna: 10.1021/NP50045A039
- 751877 Zataria multiflora: 10.1515/ZNB-1999-0616
- 999555 Bonnetia paniculata: 10.1016/0031-9422(90)85035-E
- 1297873 Ulmus davidiana: 10.1007/S12272-010-0903-0
- 863300 Eleocharis sellowiana: 10.1002/PCA.757
- 1289396 Vellozia declinans: 10.1016/0031-9422(92)80451-J
- 29760 Vitis vinifera: 10.21608/BFSA.2001.65958
- 126435 Lantana camara:
- 649173 Lantana strigocamara:
- 1924180 Eugenia moraviana: 10.1590/S0103-50532001000200009
- 1453380 Eugenia modesta: 10.1590/S0103-50532001000200009
- 54778 Ceanothus americanus: 10.1139/V61-225
- 387928 Anemone raddeana: 10.4268/CJCMM20112416
- 58331 Quercus suber: 10.1016/S0926-6690(01)00091-7
- 40708 Paeonia emodi: 10.1248/CPB.48.1771
- 197961 Scaevola floribunda: 10.1021/NP9702852
- 1279044 Melilotus messanensis: 10.1016/S0031-9422(00)89726-5
- 178137 Syncarpia glomulifera: 10.1055/S-2000-11129
- 673036 Peganum nigellastrum:
- 1137045 Vismia cayennensis: 10.1016/0031-9422(81)84067-8
- 107821 Barringtonia racemosa: 10.1002/CHIN.200630195
- 124772 Illicium difengpi:
- 309266 Ficus cordata: 10.1515/ZNB-2008-1113
- 172013 Ceriops decandra: 10.1071/CH05087
- 1389779 Tetracera boiviniana: 10.1021/NP990326P
- 127430 Myodocarpus gracilis: 10.1055/S-2006-957704
- 99438 Lumnitzera racemosa: 10.3998/ARK.5550190.0004.304
- 279243 Caraipa densifolia: 10.1021/NP50025A012
- 2054469 Dracocephalum forrestii: 10.1002/HLCA.200690271
- 52822 Alstonia scholaris: 10.21608/BFSA.2000.66312
- 4359 Sarracenia flava: 10.1016/S0031-9422(00)86845-4
- 149685 Bowdichia virgilioides: 10.1016/S0367-326X(99)00129-X
- 106660 Ampelozizyphus amazonicus: 10.1016/0031-9422(91)83076-W
- 909143 Echinops echinatus: 10.1016/J.BSE.2012.10.013
- 49827 Glycyrrhiza glabra: 10.1007/BF00272743
- 507408 Combretum imberbe: 10.1016/0031-9422(88)83135-2
- 467335 Polygonum plebeium: 10.1055/S-0028-1097706
- 1321360 Hypericum wightianum: 10.1080/10286020310001595935
- 667334 Calophyllum teysmannii: 10.3987/COM-97-7901
- 1118758 Balanops australiana: 10.1071/CH00066
- 85285 Tetracera asiatica: 10.1080/10286020600782454
- 1815893 Tetracera sarmentosa: 10.1080/10286020600782454
- 1291627 Zanthoxylum gilletii: 10.1016/J.PHYTOCHEM.2006.12.015
- 4075 Datura inoxia: 10.1093/OXFORDJOURNALS.PCP.A076871
- 167663 Gliricidia sepium: 10.1016/S0367-326X(00)00219-7
- 162708 Libidibia paraguariensis: 10.1515/ZNC-2003-1-213
- 207932 Iris missouriensis: 10.1021/NP50044A024
- 1085409 Dillenia papuana: 10.1016/0031-9422(95)00491-O
- 204972 Cylicodiscus gabunensis: 10.1016/0040-4020(95)00720-S
- 392684 Salvia roborowskii: 10.1002/CHIN.200413142
- 508985 Berlinia grandiflora: 10.1078/0944-7113-00023
- 327218 Heptapleurum heptaphyllum: 10.1016/S0031-9422(00)84983-3
- 319158 Uapaca guineensis: 10.1016/J.FITOTE.2008.09.005
- 82758 Arbutus menziesii: 10.1016/S0031-9422(00)85205-X
- 63090 Triphyophyllum peltatum: 10.1055/S-2006-957666
- 122297 Ancistrocladus heyneanus: 10.1055/S-2006-957666
- 1284895 Ozothamnus ledifolius: 10.1515/ZNC-1998-3-420
- 231906 Garcinia hanburyi: 10.1055/S-0029-1186193
- 4114 Solanum aviculare:
- 1390551 Uapaca nitida: 10.1002/(SICI)1099-1573(199903)13:2<115::AID-PTR404>3.0.CO;2-1
- 438430 Stemodia maritima: 10.1590/S0103-50532010000800025
- 2690205 Ziziphus xylopyrus: 10.1021/JF970768B
- 1977614 Crotalaria trifoliastrum: 10.1016/S0367-326X(98)00030-6
- 1085512 Ternstroemia cherryi: 10.1071/CH9650591
- 28525 Menyanthes trifoliata: 10.3891/ACTA.CHEM.SCAND.07-0446
- 1502681 Alphitonia zizyphoides: 10.1016/S0031-9422(97)00827-3
- 4378 Dillenia indica: 10.1016/J.PHYMED.2009.07.010
- 4283 Cornus florida: 10.1039/JR9390001267
- 3505 Betula pendula: 10.1002/(SICI)1099-1565(199907/08)10:4<187::AID-PCA443>3.0.CO;2-K
- 4432 Nelumbo nucifera: 10.1055/S-2006-957705
- 3645 Bertholletia excelsa: 10.1016/J.FITOTE.2004.09.008
- 263974 Bacopa monnieri: 10.1016/S0378-8741(03)00013-8
- 1609897 Syzygium formosanum: 10.1016/S2221-1691(12)60050-1
- 334497 Syzygium sandwicense:
- 219860 Syzygium claviflorum:
- 3972 Viscum album: 10.1248/CPB.54.1063
- 108362 Sida cordifolia:
- 231906 Garcinia hanburyi:
- 469923 Garcinia celebica:
- 180107 Garcinia hombroniana:
- 260132 Eugenia myrcianthes: 10.1016/S0031-9422(01)00180-7
- 115911 Achatinella: 10.1016/J.PHYTOCHEM.2006.03.005
- 74645 Rosa rugosa:
- 999598 Vismia guianensis: 10.1016/S0031-9422(00)95279-8
- 425908 Isodon japonicus: 10.1021/NP030165W
- 999599 Vismia guineensis: 10.1021/NP990226J
- 499990 Mimosa invisa: 10.1021/NP200307R
- 178749 Acacia acuminata: 10.1016/J.PHYTOCHEM.2004.03.002
- 479624 Acacia salicina: 10.1016/J.PHYTOCHEM.2004.03.002
- 216988 Betula platyphylla var. japonica: 10.1248/CPB.44.1033
- 63461 Nerium: 10.1021/NP040072U
- 4146 Olea europaea:
- 756632 Euphorbia rigida: 10.1021/NP900305J
- 1046501 Euphorbia polygonifolia: 10.1021/NP900305J
- 38847 Euphorbia segetalis: 10.1021/NP900305J
- 334667 Euphorbia burmanni: 10.1021/NP900305J
- 2068726 Ajania nubigena: 10.1002/PCA.995
- 452792 Ruta microcarpa: 10.1016/0031-9422(86)80093-0
- 2651278 Pongamia pinnata var. pinnata: 10.1021/NP030207G
- 1085512 Ternstroemia cherryi: 10.1021/NP030069V
- 210380 Mesua ferrea: 10.3390/MOLECULES16075647
- 240001 Diospyros ferrea: 10.1016/J.PHYTOCHEM.2004.03.010
- 413758 Diospyros maritima: 10.1021/NP980217V
- 260142 Syzygium cumini: 10.1021/NP980313W
- 389181 Jasminum grandiflorum: 10.1248/CPB.55.474
- 3755 Prunus dulcis:
- 66907 Rhododendron metternichii: 10.1248/YAKUSHI1947.94.6_756
- 231905 Garcinia dulcis: 10.1248/CPB.54.301
- 2026877 Eria robusta:
- 673036 Peganum nigellastrum: 10.1016/S0031-9422(99)00440-9
- 34316 Eucalyptus camaldulensis:
- 1711301 Eucalyptus flocktoniae: 10.1016/S0031-9422(00)00058-3
- 34329 Corymbia citriodora: 10.1016/S0031-9422(00)00058-3
- 326968 Ziziphus jujuba: 10.1248/CPB.54.535
- 714518 Ziziphus jujuba var. spinosa: 10.1248/CPB.54.535
- 1502681 Alphitonia zizyphoides: 10.1071/CH9722209
- 62886 Paeonia rockii:
- 39367 Salvia rosmarinus: 10.1021/NP50044A005
- 226208 Salvia miltiorrhiza: 10.1021/NP50044A005
- 588964 Salvia prionitis: 10.1021/NP50044A005
- 2886701 Salvia coulteri: 10.1021/NP50044A005
- 268919 Salvia nubicola: 10.1021/NP50044A005
- 2708779 Cussonia bancoensis: 10.1007/BF02976660
- 1938192 Oxytropis altaica: 10.1007/S10600-009-9377-Z
- 324593 Saussurea costus: 10.3390/MOLECULES14010266
- 191528 Rhododendron maximum: 10.1016/0031-9422(83)80161-7
- 49622 Rhododendron ferrugineum: 10.1016/0031-9422(83)80161-7
- 176258 Rhododendron arboreum: 10.1016/0031-9422(83)80161-7
- 432372 Alphitonia incana: 10.1002/JCCS.200400124
- 2358445 Alphitonia philippinensis: 10.1002/JCCS.200400124
- 164936 Melaleuca leucadendra: 10.1016/S0031-9422(00)88978-5
- 4058 Catharanthus roseus: 10.1021/NP800378Q
- 318066 Tridax procumbens: 10.3390/MOLECULES15096357
- 107827 Ternstroemia gymnanthera: 10.1071/CH9650591
- 109061 Alnus hirsuta: 10.1055/S-2005-916178
- 228163 Betula utilis: 10.1038/2121364B0
- 542674 Phyla dulcis: 10.1021/NP068010M
- 714511 Tadehagi triquetrum: 10.1021/JF0483117
- 1692142 Hypericum chinense: 10.1021/NP1004483
- 684760 Hypericum monogynum: 10.1021/NP1004483
- 282542 Hypericum japonicum: 10.1021/NP1004483
- 765745 Sorbus decora: 10.1021/NP1003005
- 429709 Tabebuia rosea: 10.21608/BFSA.1987.74392
- 148671 Anadenanthera colubrina: 10.1055/S-2004-818920
- 237931 Viburnum cylindricum: 10.1002/HLCA.200800420
- 60117 Cornus capitata: 10.1021/NP50046A034
- 912968 Calliandra haematocephala: 10.4314/NJNPM.V3I1.11761
- 159976 Viscum coloratum: 10.1248/CPB.54.1063
- 798610 Terminalia superba: 10.1016/J.PHYTOCHEM.2007.02.020
- 211701 Clusia columnaris: 10.1590/S0102-695X2008000100003
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 170354 Crossopteryx febrifuga: 10.1055/S-2006-962425
- 943723 Oedera genistifolia: 10.1016/0031-9422(90)80181-F
- 112393 Oedera fruticosa: 10.1016/0031-9422(90)80181-F
- 496644 Oedera calycina: 10.1016/0031-9422(90)80181-F
- 39354 Salvia abrotanoides: 10.1055/S-2006-951766
- 714518 Ziziphus jujuba var. spinosa: 10.1111/J.1744-7909.2005.00060.X
- 326968 Ziziphus jujuba:
- 701534 Lespedeza davidii: 10.4268/CJCMM20100813
- 1367312 Diospyros nigra: 10.1002/CHIN.200307143
- 361442 Vitex negundo: 10.1002/PTR.1088
- 231905 Garcinia dulcis: 10.1016/J.PHYTOCHEM.2005.06.025
- 210378 Hypericum ascyron: 10.1016/S0031-9422(99)00412-4
- 210348 Brucea javanica: 10.1002/JCCS.200500117
- 85246 Plumeria obtusa:
- 52847 Plumeria: 10.1201/9780203022320.CH4
- 164936 Melaleuca leucadendra:
- 714511 Tadehagi triquetrum: 10.1021/JF0483117
- 334497 Syzygium sandwicense: 10.1016/S0031-9422(01)00180-7
- 282553 Hypericum sampsonii: 10.1002/CHIN.200451186
- 190244 Helicteres angustifolia: 10.1016/J.PHYTOCHEM.2006.03.005
- 180924 Clusia nemorosa: 10.1016/S0031-9422(97)00746-2
- 458696 Tripterygium wilfordii: 10.1055/S-0029-1241017
- 570484 Diospyros ebenum:
- 1284871 Cassinia laevis: 10.1016/0031-9422(88)83027-9
- 667327 Calophyllum gracilipes: 10.1016/S0040-4039(97)01032-0
- 1924228 Terminalia glabrescens: 10.1590/S0103-50532003000300021
- 61143 Ceriops tagal:
- 3806 Bauhinia purpurea: 10.1002/JCCS.200200042
- 397169 Pouteria torta: 10.1021/NP50009A016
- 198795 Vismia baccifera: 10.1016/S0031-9422(00)95279-8
- 1382013 Helicteres isora: 10.26510/2394-0859.PBE.2017.07
- 556514 Lespedeza bicolor: 10.1016/J.FITOTE.2003.07.012
- 212239 Hypericum patulum: 10.3109/13880209109082884
- 62097 Plumeria rubra: 10.1055/S-0029-1240611
- 372738 Gustavia hexapetala:
- 162908 Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
- 312566 Cuphea carthagenensis: 10.1055/S-2006-959585
- 312572 Cuphea epilobiifolia: 10.1055/S-2006-959585
- 312560 Cuphea appendiculata: 10.1055/S-2006-959585
- 204151 Orthosiphon aristatus: 10.1248/CPB.48.1711
- 126418 Forsythia suspensa: 10.1055/S-1999-14093
- 542674 Phyla dulcis: 10.1021/NP068010M
- 247899 Inga punctata: 10.1021/NP50005A010
- 511531 Peperomia leptostachya: 10.1016/S0031-9422(03)00183-3
- 1719525 Peperomia humilis: 10.1016/S0031-9422(03)00183-3
- 1504171 Doliocarpus dentatus:
- 37690 Citrus trifoliata: 10.1248/CPB.58.971
- 751816 Clinopodium umbrosum: 10.1002/JCCS.199300014
- 424903 Osmanthus armatus: 10.1080/14786410802689713
- 999598 Vismia guianensis: 10.1021/NP990226J
- 268842 Diospyros mollis: 10.1055/S-0028-1099558
- 123495 Hymenopus heteromorphus:
- 54785 Ceanothus velutinus: 10.1016/S0031-9422(00)97178-4
- 1948899 Diospyros melanoxylon:
- 219860 Syzygium claviflorum:
- 107827 Ternstroemia gymnanthera:
- 28501 Cornus kousa: 10.1007/S10600-010-9550-4
- 4146 Olea europaea: 10.1248/CPB.55.784
- 210383 Paliurus hemsleyanus: 10.1016/S0031-9422(97)00313-0
- 137457 Sanguisorba officinalis: 10.1016/S0031-9422(00)97552-6
- 497234 Hedyotis lawsoniae: 10.1248/CPB.32.3906
- 36622 Chaenomeles sinensis: 10.1248/CPB.51.1318
- 237596 Rosa davurica: 10.1248/CPB.37.2232
- 1009471 Ficus pandurata: 10.1080/14786410902757899
- 3498 Morus alba:
- 264981 Ziziphus spina-christi:
- 22987 Moquilea tomentosa:
- 74647 Rosa multiflora: 10.4268/CJCMM20161216
- 1272984 Moquilea pyrifolia: 10.1021/NP960134J
- 39350 Ocimum basilicum:
- 1009467 Diospyros eriantha:
- 684760 Hypericum monogynum: 10.1021/NP1004483
- 1692142 Hypericum chinense: 10.1021/NP1004483
- 282542 Hypericum japonicum: 10.1021/NP1004483
- 271749 Cratoxylum cochinchinense: 10.1021/NP1004483
- 66392 Morus australis: 10.1021/NP970186O
- 248361 Morus indica: 10.1021/NP970186O
- 170012 Morus alba var. multicaulis: 10.3390/MOLECULES16076010
- 241921 Sorocea bonplandii: 10.3987/COM-91-5703
- 296042 Breynia fruticosa: 10.1021/NP2000914
- 252459 Eysenhardtia platycarpa: 10.1021/NP060166Z
- 211974 Berberis koreana: 10.1016/J.BMCL.2010.01.156
- 191885 Biancaea decapetala: 10.1016/0031-9422(92)83658-L
- 512270 Mimosa diplotricha: 10.1021/NP200307R
- 58305 Ilex macropoda: 10.1007/BF02976931
- 381101 Senegalia mellifera: 10.1016/J.PHYTOCHEM.2004.03.002
- 78630 Betula platyphylla: 10.1248/CPB.44.1033
- 216994 Betula lenta: 10.1515/HFSG.1991.45.4.265
- 1009589 Salacia chinensis: 10.1016/J.TET.2008.05.054
- 39358 Prunella vulgaris:
- 63479 Nerium oleander:
- 54221 Clerodendrum mandarinorum: 10.1055/S-2006-957923
- 49220 Salvia verticillata: 10.1021/NP50036A047
- 54211 Clerodendrum bungei: 10.1080/1028602021000000053
- 21880 Salvia:
- 2516474 Cratoxylum sumatranum: 10.1021/NP010395F
- 1333928 Euphorbia micractina: 10.1021/NP900305J
- 276778 Ficus sarmentosa var. thunbergii: 10.1248/CPB.42.608
- 216992 Betula ermanii:
- 1312768 Alphitonia whitei:
- 106658 Alphitonia excelsa:
- 1312767 Alphitonia petriei:
- 262931 Discaria americana: 10.1016/S0031-9422(00)97179-6
- 157914 Ziziphus mauritiana:
- 345801 Paliurus ramosissimus: 10.1016/S0031-9422(01)00234-5
- 138525 Albizia versicolor: 10.1016/S0367-326X(00)00259-8
- 1603837 Strobilanthes dimorphotricha: 10.1055/S-2005-873125
- 346985 Senna obtusifolia:
- 1688492 Aegiphila verticillata: 10.1002/MRC.1236
- 92927 Sarcandra glabra: 10.1016/0031-9422(96)00352-4
- 56065 Pongamia pinnata:
- 413762 Diospyros montana: 10.1016/S0031-9422(97)01020-0
- 413723 Diospyros bipindensis: 10.1016/S0031-9422(97)01020-0
- 1317788 Diospyros hoyleana:
- 55363 Diospyros lotus:
- 413732 Diospyros consolatae: 10.1016/S0031-9422(97)01020-0
- 413745 Diospyros fragrans:
- 2945278 Diospyros canaliculata:
- 2708802 Diospyros chevalieri:
- 413754 Diospyros maingayi:
- 570490 Diospyros monbuttensis:
- 413758 Diospyros maritima:
- 13493 Diospyros virginiana:
- 2708805 Diospyros cinnabarina:
- 1317787 Diospyros gracilescens:
- 413749 Diospyros guianensis: 10.1016/S0031-9422(97)01020-0
- 2945281 Diospyros elliptifolia: 10.1016/S0031-9422(97)01020-0
- 2708808 Diospyros kamerunensis:
- 570493 Diospyros sanza-minika:
- 227309 Diospyros ehretioides: 10.1016/S0031-9422(97)01020-0
- 413755 Diospyros malabarica: 10.1016/S0031-9422(97)01020-0
- 2945273 Diospyros albiflora: 10.1016/S0031-9422(97)01020-0
- 2945279 Diospyros candolleana: 10.1016/S0031-9422(97)01020-0
- 35925 Diospyros kaki: 10.1016/S0031-9422(97)01020-0
- 413728 Diospyros cauliflora: 10.1016/S0031-9422(97)01020-0
- 983402 Diospyros argentea:
- 268846 Diospyros sumatrana:
- 2945305 Diospyros thwaitesii: 10.1016/S0031-9422(97)01020-0
- 413718 Diospyros abyssinica:
- 1008904 Diospyros morrisiana: 10.1016/S0031-9422(97)01020-0
- 268838 Diospyros discolor:
- 1932074 Diospyros blancoi:
- 413760 Diospyros mespiliformis:
- 570487 Diospyros iturensis:
- 413727 Diospyros castanea: 10.1016/S0031-9422(97)01020-0
- 1317786 Diospyros gabunensis:
- 413763 Diospyros natalensis: 10.1016/S0031-9422(97)01020-0
- 413735 Diospyros curranii: 10.1016/S0031-9422(97)01020-0
- 413757 Diospyros mannii:
- 1317789 Diospyros obliquifolia: 10.1016/S0031-9422(97)01020-0
- 1237540 Diospyros verrucosa:
- 570481 Diospyros dendo:
- 2945307 Diospyros walkeri: 10.1016/S0031-9422(97)01020-0
- 589132 Diospyros wallichii:
- 413738 Diospyros diepenhorstii: 10.1016/S0031-9422(97)01020-0
- 570480 Diospyros crassiflora:
- 240001 Diospyros ferrea: 10.1016/S0031-9422(97)01020-0
- 570498 Diospyros zenkeri:
- 1938276 Diospyros siderophylla: 10.1016/S0031-9422(97)01020-0
- 589111 Diospyros buxifolia: 10.1016/S0031-9422(97)01020-0
- 1367301 Diospyros greenwayi: 10.1016/S0031-9422(97)01020-0
- 1367309 Diospyros leucomelas:
- 1937628 Tovomita brevistaminea: 10.1016/S0031-9422(99)00274-5
- 1569406 Eremanthus veadeiroensis: 10.1016/S0305-1978(02)00027-3
- 296037 Phyllanthus reticulatus: 10.1016/S0031-9422(00)94448-0
- 1609897 Syzygium formosanum: 10.1021/NP980313W
- 13427 Cichorium intybus: 10.1021/NP800001V
- 310427 Jasminum lanceolarium: 10.1248/CPB.55.474
- 340447 Vatica diospyroides: 10.1021/JO9902087
- 765745 Sorbus decora: 10.1021/NP1003005
- 295139 Leptospermum scoparium: 10.1002/ARDP.19963291005
- 860794 Hypericum geminiflorum: 10.1016/S0031-9422(96)00644-9
- 84005 Arbutus unedo:
- 496609 Cyclolepis genistoides: 10.1016/S0031-9422(97)00021-6
- 73757 Melaleuca ericifolia: 10.1021/NP800360A
- 1089417 Microtropis fokienensis: 10.1021/NP800093A
- 1609888 Perrottetia arisanensis: 10.1021/NP800093A
- 867530 Stenocereus eruca: 10.1021/NP970364D
- 1325988 Ixeridium gracile: 10.1007/S10600-008-9078-Z
- 45171 Paeonia suffruticosa:
- 2039553 Salvia xalapensis:
- 2569965 Stemodia foliosa: 10.1021/NP800106X
- 62886 Paeonia rockii: 10.1021/NP200359V
- 1007786 Gladiolus italicus: 10.1007/S13369-010-0015-7
- 709061 Artocarpus rigidus: 10.1021/NP1002065
- 228354 Tephrosia purpurea:
- 3956 Combretum indicum: 10.1007/BF02976955
- 66386 Ficus pumila: 10.1248/CPB.46.1647
- 2708779 Cussonia bancoensis: 10.1021/NP020412G
- 198768 Harungana madagascariensis:
- 1679376 Dichapetalum gelonioides: 10.1021/NP058083Q
- 211500 Betula maximowicziana: 10.1007/BF00599285
- 109063 Alnus japonica: 10.1016/0031-9422(81)83035-X
- 2862098 Stemodia trifoliata: 10.1002/MRC.2597
- 158927 Calophyllum inophyllum: 10.2174/157017811796064430
- 210380 Mesua ferrea:
- 169244 Dillenia philippinensis: 10.1248/CPB.59.397
- 489987 Gymnosporia cassinoides: 10.1016/0031-9422(90)85192-I
- 2822244 Maytenus canariensis: 10.1016/0031-9422(90)85192-I
- 2029442 Vatica harmandiana: 10.1021/NP020379Y
- 35924 Paeonia lactiflora:
- 368785 Koompassia malaccensis: 10.1248/CPB.44.2249
- 1157099 Enkianthus cernuus: 10.1016/0031-9422(83)80162-9
- 41788 Stauntonia hexaphylla: 10.1016/S0031-9422(97)00588-8
- 2321275 Coussarea paniculata: 10.1021/NP0204848
- 1856781 Couepia polyandra: 10.1021/NP0301893
- 13715 Tetracentron sinense: 10.1016/S0031-9422(99)00457-4
- 68527 Aegle marmelos: 10.1080/14786410310001608037
- 1874238 Mosla dianthera: 10.1248/CPB.47.1152
- 2026502 Salvia longistyla: 10.1016/0031-9422(84)83092-7
- 34316 Eucalyptus camaldulensis:
- 107240 Scoparia dulcis:
- 413731 Diospyros celebica: 10.1039/P19860000675
- 378027 Ficus polita: 10.3998/ARK.5550190.0011.227
- 41396 Tectona grandis:
- 39331 Lavandula latifolia: 10.1016/0031-9422(92)80309-3
- 3972 Viscum album: 10.1248/CPB.35.3292
- 2268751 Tovomita fructipendula: 10.1016/S0031-9422(00)00296-X
- 1937627 Tovomita brasiliensis: 10.1016/S0031-9422(00)00296-X
- 450057 Swartzia arborescens: 10.3987/COM-95-7249
- 378017 Ficus conraui: 10.1002/HLCA.201100173
- 13523 Euptelea polyandra:
- 66629 Fagonia indica: 10.1016/S0031-9422(98)00750-X
- 211713 Clusia paralicola: 10.3987/COM-01-S(K)67
- 271748 Cratoxylum arborescens: 10.1055/S-2006-951725
- 3755 Prunus dulcis:
- 49169 Rhododendron ovatum: 10.4268/CJCMM20130315
- 284673 Betula alnoides:
- 4270 Byrsonima crassifolia: 10.3109/13880209509088143
- 142522 Harpalyce brasiliana:
- 999597 Hypericum fauriei: 10.1007/BF00598324
- 268905 Salvia farinacea: 10.21779/2542-0321-2016-31-2-51-53
- 204129 Mesosphaerum suaveolens: 10.1016/0031-9422(83)80163-0
- 39367 Salvia rosmarinus:
- 980664 Lepechinia caulescens: 10.1016/S0031-9422(00)89540-0
- 2652355 Buxus wallichiana: 10.1016/S0031-9422(00)86539-5
- 212141 Fagus taurica: 10.1007/978-1-4615-4913-0_23
- 268843 Diospyros rhodocalyx: 10.1055/S-2006-958085
- 23211 Pyrus communis: 10.4268/CJCMM20131917
- 1266558 Origanum compactum: 10.1055/S-2006-962358
- 260145 Ugni molinae: 10.1016/J.BMC.2006.04.021
- 392697 Salvia thymoides: 10.1016/S0031-9422(97)80021-0
- 947117 Valeriana laxiflora: 10.1055/S-2004-827149
- 279240 Marila laxiflora: 10.1076/PHBI.36.2.103.4603
- 204131 Isodon coetsa: 10.1016/0031-9422(93)80051-S
- 3490 Artocarpus integer: 10.1016/S0031-9422(00)90605-8
- 3489 Artocarpus heterophyllus: 10.1016/S0031-9422(00)90605-8
- 1868807 Couepia ulei: 10.1007/BF02980101
- 237951 Viburnum odoratissimum: 10.1002/HLCA.200390068
- 48247 Retanilla trinervia: 10.1002/(SICI)1099-1573(199711)11:7<504::AID-PTR145>3.0.CO;2-O
- 74645 Rosa rugosa: 10.1016/J.BMCL.2013.12.098
- 1233750 Gardenia saxatilis: 10.1016/S0378-8741(03)00261-7
- 141189 Woodfordia fruticosa: 10.1055/S-0028-1097262
- 3258 Equisetum arvense: 10.1016/0031-9422(73)80050-0
- 448037 Clematoclethra scandens: 10.1007/S10600-013-0614-0
- 53205 Ilex latifolia: 10.3329/DUJPS.V3I1.189
- 49619 Rhododendron anthopogon: 10.1007/S10600-013-0640-Y
- 986201 Condea albida: 10.1021/NP50067A028
- 578549 Terminalia brachystemma: 10.1016/J.FITOTE.2009.05.006
- 1720382 Lycopus asper:
- 516551 Lycopus lucidus:
- 16922 Camptotheca acuminata: 10.1002/JCCS.198500029
- 1608024 Dialium excelsum: 10.1515/ZNB-2011-0610
- 1602062 Goniothalamus thwaitesii: 10.1016/S0031-9422(00)00346-0
- 403115 Rauvolfia vomitoria: 10.1007/S10600-011-9944-Y
- 1042139 Syzygium grande: 10.1002/MRC.1954
- 51240 Juglans regia:
- 1871529 Tephrosia angustissima: 10.1055/S-2006-962679
- 271746 Calophyllum macrocarpum: 10.1016/S0031-9422(00)84521-5
- 2268749 Tovomita choisyana: 10.1016/S0031-9422(00)80565-8
- 486170 Luxemburgia octandra: 10.1590/S0103-50532004000100023
- 883786 Henriettea fascicularis: 10.1021/NP0201164
- 1288024 Terminalia elliptica: 10.1021/NP50045A039
- 1489821 Terminalia alata: 10.1021/NP50045A039
- 172200 Terminalia arjuna: 10.1021/NP50045A039
- 751877 Zataria multiflora: 10.1515/ZNB-1999-0616
- 999555 Bonnetia paniculata: 10.1016/0031-9422(90)85035-E
- 1297873 Ulmus davidiana: 10.1007/S12272-010-0903-0
- 863300 Eleocharis sellowiana: 10.1002/PCA.757
- 1289396 Vellozia declinans: 10.1016/0031-9422(92)80451-J
- 29760 Vitis vinifera: 10.21608/BFSA.2001.65958
- 126435 Lantana camara:
- 649173 Lantana strigocamara:
- 1924180 Eugenia moraviana: 10.1590/S0103-50532001000200009
- 1453380 Eugenia modesta: 10.1590/S0103-50532001000200009
- 54778 Ceanothus americanus: 10.1139/V61-225
- 387928 Anemone raddeana: 10.4268/CJCMM20112416
- 58331 Quercus suber: 10.1016/S0926-6690(01)00091-7
- 40708 Paeonia emodi: 10.1248/CPB.48.1771
- 197961 Scaevola floribunda: 10.1021/NP9702852
- 1279044 Melilotus messanensis: 10.1016/S0031-9422(00)89726-5
- 178137 Syncarpia glomulifera: 10.1055/S-2000-11129
- 673036 Peganum nigellastrum:
- 1137045 Vismia cayennensis: 10.1016/0031-9422(81)84067-8
- 107821 Barringtonia racemosa: 10.1002/CHIN.200630195
- 124772 Illicium difengpi:
- 309266 Ficus cordata: 10.1515/ZNB-2008-1113
- 172013 Ceriops decandra: 10.1071/CH05087
- 1389779 Tetracera boiviniana: 10.1021/NP990326P
- 127430 Myodocarpus gracilis: 10.1055/S-2006-957704
- 99438 Lumnitzera racemosa: 10.3998/ARK.5550190.0004.304
- 279243 Caraipa densifolia: 10.1021/NP50025A012
- 2054469 Dracocephalum forrestii: 10.1002/HLCA.200690271
- 52822 Alstonia scholaris: 10.21608/BFSA.2000.66312
- 4359 Sarracenia flava: 10.1016/S0031-9422(00)86845-4
- 149685 Bowdichia virgilioides: 10.1016/S0367-326X(99)00129-X
- 106660 Ampelozizyphus amazonicus: 10.1016/0031-9422(91)83076-W
- 909143 Echinops echinatus: 10.1016/J.BSE.2012.10.013
- 49827 Glycyrrhiza glabra: 10.1007/BF00272743
- 507408 Combretum imberbe: 10.1016/0031-9422(88)83135-2
- 467335 Polygonum plebeium: 10.1055/S-0028-1097706
- 1321360 Hypericum wightianum: 10.1080/10286020310001595935
- 667334 Calophyllum teysmannii: 10.3987/COM-97-7901
- 1118758 Balanops australiana: 10.1071/CH00066
- 85285 Tetracera asiatica: 10.1080/10286020600782454
- 1815893 Tetracera sarmentosa: 10.1080/10286020600782454
- 1291627 Zanthoxylum gilletii: 10.1016/J.PHYTOCHEM.2006.12.015
- 4075 Datura inoxia: 10.1093/OXFORDJOURNALS.PCP.A076871
- 167663 Gliricidia sepium: 10.1016/S0367-326X(00)00219-7
- 162708 Libidibia paraguariensis: 10.1515/ZNC-2003-1-213
- 207932 Iris missouriensis: 10.1021/NP50044A024
- 1085409 Dillenia papuana: 10.1016/0031-9422(95)00491-O
- 204972 Cylicodiscus gabunensis: 10.1016/0040-4020(95)00720-S
- 392684 Salvia roborowskii: 10.1002/CHIN.200413142
- 508985 Berlinia grandiflora: 10.1078/0944-7113-00023
- 327218 Heptapleurum heptaphyllum: 10.1016/S0031-9422(00)84983-3
- 319158 Uapaca guineensis: 10.1016/J.FITOTE.2008.09.005
- 82758 Arbutus menziesii: 10.1016/S0031-9422(00)85205-X
- 63090 Triphyophyllum peltatum: 10.1055/S-2006-957666
- 122297 Ancistrocladus heyneanus: 10.1055/S-2006-957666
- 1284895 Ozothamnus ledifolius: 10.1515/ZNC-1998-3-420
- 231906 Garcinia hanburyi: 10.1055/S-0029-1186193
- 4114 Solanum aviculare:
- 1390551 Uapaca nitida: 10.1002/(SICI)1099-1573(199903)13:2<115::AID-PTR404>3.0.CO;2-1
- 438430 Stemodia maritima: 10.1590/S0103-50532010000800025
- 2690205 Ziziphus xylopyrus: 10.1021/JF970768B
- 1977614 Crotalaria trifoliastrum: 10.1016/S0367-326X(98)00030-6
- 1085512 Ternstroemia cherryi: 10.1071/CH9650591
- 28525 Menyanthes trifoliata: 10.3891/ACTA.CHEM.SCAND.07-0446
- 1502681 Alphitonia zizyphoides: 10.1016/S0031-9422(97)00827-3
- 4378 Dillenia indica: 10.1016/J.PHYMED.2009.07.010
- 4283 Cornus florida: 10.1039/JR9390001267
- 3505 Betula pendula: 10.1002/(SICI)1099-1565(199907/08)10:4<187::AID-PCA443>3.0.CO;2-K
- 4432 Nelumbo nucifera: 10.1055/S-2006-957705
- 3645 Bertholletia excelsa: 10.1016/J.FITOTE.2004.09.008
- 263974 Bacopa monnieri: 10.1016/S0378-8741(03)00013-8
- 1609897 Syzygium formosanum: 10.1016/S2221-1691(12)60050-1
- 334497 Syzygium sandwicense:
- 219860 Syzygium claviflorum:
- 3972 Viscum album: 10.1248/CPB.54.1063
- 108362 Sida cordifolia:
- 231906 Garcinia hanburyi:
- 469923 Garcinia celebica:
- 180107 Garcinia hombroniana:
- 260132 Eugenia myrcianthes: 10.1016/S0031-9422(01)00180-7
- 115911 Achatinella: 10.1016/J.PHYTOCHEM.2006.03.005
- 74645 Rosa rugosa:
- 999598 Vismia guianensis: 10.1016/S0031-9422(00)95279-8
- 425908 Isodon japonicus: 10.1021/NP030165W
- 999599 Vismia guineensis: 10.1021/NP990226J
- 499990 Mimosa invisa: 10.1021/NP200307R
- 178749 Acacia acuminata: 10.1016/J.PHYTOCHEM.2004.03.002
- 479624 Acacia salicina: 10.1016/J.PHYTOCHEM.2004.03.002
- 216988 Betula platyphylla var. japonica: 10.1248/CPB.44.1033
- 63461 Nerium: 10.1021/NP040072U
- 4146 Olea europaea:
- 756632 Euphorbia rigida: 10.1021/NP900305J
- 1046501 Euphorbia polygonifolia: 10.1021/NP900305J
- 38847 Euphorbia segetalis: 10.1021/NP900305J
- 334667 Euphorbia burmanni: 10.1021/NP900305J
- 2068726 Ajania nubigena: 10.1002/PCA.995
- 452792 Ruta microcarpa: 10.1016/0031-9422(86)80093-0
- 2651278 Pongamia pinnata var. pinnata: 10.1021/NP030207G
- 1085512 Ternstroemia cherryi: 10.1021/NP030069V
- 210380 Mesua ferrea: 10.3390/MOLECULES16075647
- 240001 Diospyros ferrea: 10.1016/J.PHYTOCHEM.2004.03.010
- 413758 Diospyros maritima: 10.1021/NP980217V
- 260142 Syzygium cumini: 10.1021/NP980313W
- 389181 Jasminum grandiflorum: 10.1248/CPB.55.474
- 3755 Prunus dulcis:
- 66907 Rhododendron metternichii: 10.1248/YAKUSHI1947.94.6_756
- 231905 Garcinia dulcis: 10.1248/CPB.54.301
- 2026877 Eria robusta:
- 673036 Peganum nigellastrum: 10.1016/S0031-9422(99)00440-9
- 34316 Eucalyptus camaldulensis:
- 1711301 Eucalyptus flocktoniae: 10.1016/S0031-9422(00)00058-3
- 34329 Corymbia citriodora: 10.1016/S0031-9422(00)00058-3
- 326968 Ziziphus jujuba: 10.1248/CPB.54.535
- 714518 Ziziphus jujuba var. spinosa: 10.1248/CPB.54.535
- 1502681 Alphitonia zizyphoides: 10.1071/CH9722209
- 62886 Paeonia rockii:
- 39367 Salvia rosmarinus: 10.1021/NP50044A005
- 226208 Salvia miltiorrhiza: 10.1021/NP50044A005
- 588964 Salvia prionitis: 10.1021/NP50044A005
- 2886701 Salvia coulteri: 10.1021/NP50044A005
- 268919 Salvia nubicola: 10.1021/NP50044A005
- 2708779 Cussonia bancoensis: 10.1007/BF02976660
- 1938192 Oxytropis altaica: 10.1007/S10600-009-9377-Z
- 324593 Saussurea costus: 10.3390/MOLECULES14010266
- 191528 Rhododendron maximum: 10.1016/0031-9422(83)80161-7
- 49622 Rhododendron ferrugineum: 10.1016/0031-9422(83)80161-7
- 176258 Rhododendron arboreum: 10.1016/0031-9422(83)80161-7
- 432372 Alphitonia incana: 10.1002/JCCS.200400124
- 2358445 Alphitonia philippinensis: 10.1002/JCCS.200400124
- 164936 Melaleuca leucadendra: 10.1016/S0031-9422(00)88978-5
- 4058 Catharanthus roseus: 10.1021/NP800378Q
- 318066 Tridax procumbens: 10.3390/MOLECULES15096357
- 107827 Ternstroemia gymnanthera: 10.1071/CH9650591
- 109061 Alnus hirsuta: 10.1055/S-2005-916178
- 228163 Betula utilis: 10.1038/2121364B0
- 542674 Phyla dulcis: 10.1021/NP068010M
- 714511 Tadehagi triquetrum: 10.1021/JF0483117
- 1692142 Hypericum chinense: 10.1021/NP1004483
- 684760 Hypericum monogynum: 10.1021/NP1004483
- 282542 Hypericum japonicum: 10.1021/NP1004483
- 765745 Sorbus decora: 10.1021/NP1003005
- 9606 Homo sapiens: -
- 124772 Illicium Difengpi K. L. B. Et K. I. M.: -
- 36622 Chaenomeles Sinensis (Thouin) Koehne: -
- 714493 Pulsatilla chinensis (Bge.) Regel: -
- 326968 Ziziphus jujuba Mill.: -
- 33090 Plants: -
- 33090 Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Prativa Biswasroy, Deepak Pradhan, Dilip Kumar Pradhan, Goutam Ghosh, Goutam Rath. Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis.
AAPS PharmSciTech.
2024 Mar; 25(3):57. doi:
10.1208/s12249-024-02774-1
. [PMID: 38472545] - Yu-Hao Shi, Yi Nan, Wei Zheng, Lan Yao, Hai-Zhen Liang, Xiao-Juan Chen, Juan Song, Jie Zhang, De-Xian Jia, Qian Wang, Bai-Ping Ma. [Qualitative and semiquantitative analyses of the chemical components of the seed coat and kernel of Ziziphi Spinosae Semen].
Se pu = Chinese journal of chromatography.
2024 Mar; 42(3):234-244. doi:
10.3724/sp.j.1123.2023.09015
. [PMID: 38503700] - Huanyu Zhang, Xiance Che, Hongyan Jing, Yaowu Su, Wenqi Yang, Rubing Wang, Guoqi Zhang, Jie Meng, Wei Yuan, Juan Wang, Wenyuan Gao. A New Potent Inhibitor against α-Glucosidase Based on an In Vitro Enzymatic Synthesis Approach.
Molecules (Basel, Switzerland).
2024 Feb; 29(4):. doi:
10.3390/molecules29040878
. [PMID: 38398628] - Feyisayo O Adepoju, Ksenia V Sokolova, Irina F Gette, Irina G Danilova, Mikhail V Tsurkan, Alicia C Mondragon, Elena G Kovaleva, Jose Manuel Miranda. Protective Effect of Betulin on Streptozotocin-Nicotinamide-Induced Diabetes in Female Rats.
International journal of molecular sciences.
2024 Feb; 25(4):. doi:
10.3390/ijms25042166
. [PMID: 38396842] - Sílvia Fernandes, Mariana Vieira, Cristina Prudêncio, Ricardo Ferraz. Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives.
International journal of molecular sciences.
2024 Feb; 25(4):. doi:
10.3390/ijms25042108
. [PMID: 38396785] - Hye-Yeon Lee, Kyung-Jin Min. Betulinic Acid Increases the Lifespan of Drosophila melanogaster via Sir2 and FoxO Activation.
Nutrients.
2024 Feb; 16(3):. doi:
10.3390/nu16030441
. [PMID: 38337725] - Yaowen Liu, Tianqing Nie, Jinjun Hou, Huali Long, Zijia Zhang, Min Lei, Yechun Xu, Wanying Wu. Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2.
Steroids.
2024 Feb; 202(?):109351. doi:
10.1016/j.steroids.2023.109351
. [PMID: 38101718] - Olexander M Semenenko, Victoria V Lipson, Alina O Sadchenko, Olga V Vashchenko, Natalia A Kasian, Liliia V Sviechnikova, Longin M Lisetski, Mykola L Babak, Volodymyr M Vakula, Oleksandr V Borysov, Yuliia V Holota, Sergey O Zozulya, Petro O Borysko, Olexander V Mazepa. Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes.
Steroids.
2024 Jan; 201(?):109332. doi:
10.1016/j.steroids.2023.109332
. [PMID: 37939980] - Martina Wimmerová, Uladzimir Bildziukevich, Zdeněk Wimmer. Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents.
Molecules (Basel, Switzerland).
2023 Nov; 28(23):. doi:
10.3390/molecules28237718
. [PMID: 38067449] - Q Zhang, M Zhang, Y Liu, Y Wang, F Lv, Y Wang. [Exploring the therapeutic mechanism of Liuwei Suanzao decoction for perimenopausal insomnia based on network pharmacology and animal experiments].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2023 Sep; 43(9):1536-1547. doi:
10.12122/j.issn.1673-4254.2023.09.11
. [PMID: 37814868] - Neeraj Kumari, Manoj Kumar, Nisha Chaudhary, Baohong Zhang, Radha, Deepak Chandran, Shourabh Joshi, Daljeet Singh, Abhijit Dey, Sureshkumar Rajalingam, Krishnaprabu Natarajan, Muthamilselvan Muthukumar, Pran Mohankumar, Vijay Sheri, Sangram Dhumal, Jose M Lorenzo. Exploring the Chemical and Biological Potential of Jamun (Syzygium cumini (L.) Skeels) Leaves: A Comprehensive Review.
Chemistry & biodiversity.
2023 Sep; ?(?):e202300479. doi:
10.1002/cbdv.202300479
. [PMID: 37667613] - Huijuan Mu, Yuli Sun, Bo Yuan, Ying Wang. Betulinic acid in the treatment of breast cancer: Application and mechanism progress.
Fitoterapia.
2023 Jul; 169(?):105617. doi:
10.1016/j.fitote.2023.105617
. [PMID: 37479118] - Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194
. [PMID: 37200814] - Reem S Alruhaimi. Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats.
Environmental science and pollution research international.
2023 Feb; ?(?):. doi:
10.1007/s11356-023-25917-6
. [PMID: 36808036] - Li Tao, Kehui Zhou, Yang Zhao, Xiangyu Xia, Yajie Guo, Yang Gao, Guoping Peng, Yanqing Liu. Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation.
Journal of ethnopharmacology.
2023 Feb; ?(?):116295. doi:
10.1016/j.jep.2023.116295
. [PMID: 36813244] - Chenglin Yang, Yunqin Chen, Mengran Yang, Jiayan Li, You Wu, Hui Fan, Xiangyi Kong, Can Ning, Siqi Wang, Wenguang Xiao, Zhihang Yuan, Jine Yi, Jing Wu. Betulinic acid alleviates zearalenone-induced uterine injury in mice.
Environmental pollution (Barking, Essex : 1987).
2023 Jan; 316(Pt 1):120435. doi:
10.1016/j.envpol.2022.120435
. [PMID: 36257561] - Martina S Savova, Monika N Todorova, Apostol G Apostolov, Galina T Yahubyan, Milen I Georgiev. Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Dec; 156(?):113862. doi:
10.1016/j.biopha.2022.113862
. [PMID: 36242845] - S J Sudharshan, Ananth Krishna Narayanan, Jemima Princilly, Madhu Dyavaiah, Dinesh A Nagegowda. Betulinic acid mitigates oxidative stress-mediated apoptosis and enhances longevity in the yeast Saccharomyces cerevisiae model.
Free radical research.
2022 Nov; 56(11-12):699-712. doi:
10.1080/10715762.2023.2166505
. [PMID: 36624963] - Chenlu Zhang, Yameng Liu, Ying Wang, Xiu Ge, Tingying Jiao, Jianpeng Yin, Kanglong Wang, Cuina Li, Shimeng Guo, Xin Xie, Cen Xie, Fajun Nan. Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis.
Journal of medicinal chemistry.
2022 10; 65(19):13452-13472. doi:
10.1021/acs.jmedchem.2c01394
. [PMID: 36107013] - Huizi Zhao, Lin Wu, Yuan Zhang, Shiqi Feng, Yuhao Ding, Xin Deng, Rui Feng, Jun Li, Taotao Ma, Cheng Huang. Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation.
Journal of ethnopharmacology.
2022 Oct; 296(?):115459. doi:
10.1016/j.jep.2022.115459
. [PMID: 35714879] - Gang Wang, Yu Yang, Du Yi, Lu Yuan, Pei-Hao Yin, Xu Ke, Wang Jun-Jie, Min-Fang Tao. Eudragit S100 prepared pH-responsive liposomes-loaded betulinic acid against colorectal cancer in vitro and in vivo.
Journal of liposome research.
2022 Sep; 32(3):250-264. doi:
10.1080/08982104.2021.1999974
. [PMID: 34895013] - You Huang, Zihan Zhu, Chenxi Luo, Chaoyang Ma, Lijuan Zhu, Li Kong, Rongfang Li, Jing Wu, Zhihang Yuan, Jine Yi. Betulinic acid attenuates cognitive dysfunction, oxidative stress, and inflammation in a model of T-2 toxin-induced brain damage.
Environmental science and pollution research international.
2022 Jul; 29(34):52098-52110. doi:
10.1007/s11356-022-19498-z
. [PMID: 35254615] - Sameh S Elhady, Elsayed A Ibrahim, Marwa S Goda, Mohamed S Nafie, Hanan Samir, Reem M Diri, Abdulrahman M Alahdal, Ama Kyeraa Thomford, Alaa El Gindy, Ghada M Hadad, Jihan M Badr, Reda F A Abdelhameed. GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea.
Molecules (Basel, Switzerland).
2022 Jun; 27(13):. doi:
10.3390/molecules27134109
. [PMID: 35807354] - Yingying Chen, Xinchen Wang, Xinyuan Ma, Shuobin Liang, Qianqian Gao, Elena V Tretyakova, Yongmin Zhang, Demin Zhou, Sulong Xiao. Facial Synthesis and Bioevaluation of Well-Defined OEGylated Betulinic Acid-Cyclodextrin Conjugates for Inhibition of Influenza Infection.
Molecules (Basel, Switzerland).
2022 Feb; 27(4):. doi:
10.3390/molecules27041163
. [PMID: 35208962] - Zhengqi Cheng, Yue Li, Ke Wang, Xue Zhu, Priyanka Tharkar, Wenying Shu, Ting Zhang, Shaoxue Zeng, Ling Zhu, Michael Murray, Wojciech Chrzanowski, Fanfan Zhou. Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Müller cells against oxidative injury.
Experimental eye research.
2022 02; 215(?):108906. doi:
10.1016/j.exer.2021.108906
. [PMID: 34953864] - Rassameepen Phonarknguen, Saksit Nobsathian, Kanjana Assawasuparerk. Effect of Betulinic acid Extraction from Guava (Psidium guajava Linn.) Leaves Against Human Cholangiocarcinoma Cells.
Asian Pacific journal of cancer prevention : APJCP.
2022 Feb; 23(2):583-590. doi:
10.31557/apjcp.2022.23.2.583
. [PMID: 35225471] - Li-Yun Zheng, Xi Zou, Yan-Li Wang, Min Zou, Fang Ma, Ning Wang, Jia-Wen Li, Ming-Sheng Wang, Hsin-Yi Hung, Qiang Wang. Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy.
European journal of pharmacology.
2022 Jan; 914(?):174686. doi:
10.1016/j.ejphar.2021.174686
. [PMID: 34883073] - Hao Sun, Dan Wang, Mengjin Xu, Yi Gao, Fan Li. Methodological Verification-based Screening of the Representative Ingredients for Traditional Chinese Medicine: Taking Astragalus as an Example for Interfering with Cervical Cancer.
Current computer-aided drug design.
2022; 18(5):347-362. doi:
10.2174/1573409918666220823120304
. [PMID: 36017857] - Aboli Girme, Prajkta Bhoj, Ganesh Saste, Sandeep Pawar, Amit Mirgal, Dipak Raut, Machindra Chavan, Lal Hingorani. Development and Validation of RP-HPLC Method for Vicenin-2, Orientin, Cynaroside, Betulinic Acid, Genistein, and Major Eight Bioactive Constituents with LC-ESI-MS/MS Profiling in Ocimum Genus.
Journal of AOAC International.
2021 Dec; 104(6):1634-1651. doi:
10.1093/jaoacint/qsab067
. [PMID: 33930142] - Hongjuan Wang, Hongxia Wang, Ling Ge, Yanying Zhao, Kongxi Zhu, Zhaosheng Chen, Qiong Wu, Yu Xin, Jianqiang Guo. Betulinic acid targets drug-resistant human gastric cancer cells by inducing autophagic cell death, suppresses cell migration and invasion, and modulates the ERK/MEK signaling pathway.
Acta biochimica Polonica.
2021 Dec; 69(1):25-30. doi:
10.18388/abp.2020_5530
. [PMID: 34860480] - Lin Huang, Lijuan Zhu, Zhaoping Ou, Chaoyang Ma, Li Kong, You Huang, Yazhi Chen, Haoqiang Zhao, Lixin Wen, Jing Wu, Zhihang Yuan, Jine Yi. Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice.
International immunopharmacology.
2021 Dec; 101(Pt B):108210. doi:
10.1016/j.intimp.2021.108210
. [PMID: 34628148] - Gbadebo E Adeleke, Oluwatosin A Adaramoye. Betulinic acid abates N-nitrosodimethylamine-induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats.
Journal of biochemical and molecular toxicology.
2021 Nov; 35(11):e22901. doi:
10.1002/jbt.22901
. [PMID: 34472159] - Alessandra F Serain, Lavinia Morosi, Tommaso Ceruti, Cristina Matteo, Marina Meroni, Elaine Minatel, Massimo Zucchetti, Marcos J Salvador. Betulinic acid and its spray dried microparticle formulation: In vitro PDT effect against ovarian carcinoma cell line and in vivo plasma and tumor disposition.
Journal of photochemistry and photobiology. B, Biology.
2021 Nov; 224(?):112328. doi:
10.1016/j.jphotobiol.2021.112328
. [PMID: 34628206] - Xiaowen Li, Xianglin Wang, Sha Liu, Ji Wang, XiangYan Liu, Yuanyuan Zhu, Linyu Zhang, Rongfang Li. Betulinic acid attenuates T-2 toxin-induced cytotoxicity in porcine kidney cells by blocking oxidative stress and endoplasmic reticulum stress.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Nov; 249(?):109124. doi:
10.1016/j.cbpc.2021.109124
. [PMID: 34224893] - Hyun Kyung Kim, Yejee Park, Minhye Shin, Jun-Mo Kim, Gwang-Woong Go. Betulinic Acid Suppresses de novo Lipogenesis by Inhibiting Insulin and IGF1 Signaling as Upstream Effectors of the Nutrient-Sensing mTOR Pathway.
Journal of agricultural and food chemistry.
2021 Oct; 69(42):12465-12473. doi:
10.1021/acs.jafc.1c04797
. [PMID: 34645271] - Tomasz Kowalczyk, Przemysław Sitarek, Anna Merecz-Sadowska, Monika Szyposzyńska, Aleksandra Spławska, Leslaw Gorniak, Michał Bijak, Tomasz Śliwiński. Methyl Jasmonate Effect on Betulinic Acid Content and Biological Properties of Extract from Senna obtusifolia Transgenic Hairy Roots.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206208
. [PMID: 34684788] - Mi-Hyeon Hong, Se-Won Na, Youn-Jae Jang, Jung-Joo Yoon, Yun-Jung Lee, Ho-Sub Lee, Hye-Yoom Kim, Dae-Gill Kang. Betulinic Acid Improves Cardiac-Renal Dysfunction Caused by Hypertrophy through Calcineurin-NFATc3 Signaling.
Nutrients.
2021 Sep; 13(10):. doi:
10.3390/nu13103484
. [PMID: 34684485] - Ye Zhong, Nan Liang, Yang Liu, Mao-Sheng Cheng. Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review.
Chinese journal of natural medicines.
2021 Sep; 19(9):641-647. doi:
10.1016/s1875-5364(21)60097-3
. [PMID: 34561074] - Tomasz Kowalczyk, Przemysław Sitarek, Monika Toma, Patricia Rijo, Eva Domínguez-Martín, Irene Falcó, Gloria Sánchez, Tomasz Śliwiński. Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological Properties in Various Biological Models.
Chemistry & biodiversity.
2021 Aug; 18(8):e2100455. doi:
10.1002/cbdv.202100455
. [PMID: 34185351] - Dan-Hua He, Yu-Fei Chen, Yi-Le Zhou, Shi-Bing Zhang, Ming Hong, Xianjun Yu, Su-Fen Wei, Xiang-Zhen Fan, Si-Yi Li, Qi Wang, Yongzhi Lu, Yong-Qiang Liu. Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non-small cell lung cancer.
Cancer science.
2021 Aug; 112(8):3218-3232. doi:
10.1111/cas.15005
. [PMID: 34080260] - Haider N Sultani, Ibrahim Morgan, Hidayat Hussain, Andreas H Roos, Haleh H Haeri, Goran N Kaluđerović, Dariush Hinderberger, Bernhard Westermann. Access to New Cytotoxic Triterpene and Steroidal Acid-TEMPO Conjugates by Ugi Multicomponent-Reactions.
International journal of molecular sciences.
2021 Jul; 22(13):. doi:
10.3390/ijms22137125
. [PMID: 34281176] - Ahmed Wahab Obeng, Yaw Duah Boakye, Theresa Appiah Agana, Georgina Isabella Djameh, Daniel Boamah, Francis Adu. Anti-trypanosomal and anthelminthic properties of ethanol and aqueous extracts of Tetrapleura tetraptera Taub.
Veterinary parasitology.
2021 Jun; 294(?):109449. doi:
10.1016/j.vetpar.2021.109449
. [PMID: 33991727] - Veena S Patel, Usmangani K Chhalotiya, Sandip B Patel, Jivani Nuruddin. Simultaneous Quantification of Betulinic Acid, Lupeol, and β-Sitosterol in Madhuca longifolia Methanolic Extract of Bark by Liquid Chromatography-Tandem Mass Spectrometric Method.
Journal of AOAC International.
2021 May; 104(2):498-505. doi:
10.1093/jaoacint/qsaa128
. [PMID: 33615381] - Hani A Alhadrami, Ahmed M Sayed, Ahmed M Sharif, Esam I Azhar, Mostafa E Rateb. Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics.
Molecules (Basel, Switzerland).
2021 May; 26(9):. doi:
10.3390/molecules26092654
. [PMID: 34062737] - Ching-Feng Chiu, Hsin-Yi Chang, Chun-Yine Huang, Chen-Zou Mau, Tzu-Ting Kuo, Hsiu-Chuan Lee, Shih-Yi Huang. Betulinic Acid Affects the Energy-Related Proteomic Profiling in Pancreatic Ductal Adenocarcinoma Cells.
Molecules (Basel, Switzerland).
2021 Apr; 26(9):. doi:
10.3390/molecules26092482
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Molecules (Basel, Switzerland).
2021 Apr; 26(8):. doi:
10.3390/molecules26082200
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Journal of ethnopharmacology.
2021 Apr; 269(?):113737. doi:
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Journal of food biochemistry.
2021 03; 45(3):e13288. doi:
10.1111/jfbc.13288
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Molecules (Basel, Switzerland).
2021 Feb; 26(4):. doi:
10.3390/molecules26041081
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Phytochemistry.
2021 Feb; 182(?):112608. doi:
10.1016/j.phytochem.2020.112608
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Journal of natural products.
2021 01; 84(1):26-36. doi:
10.1021/acs.jnatprod.0c00832
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Molecules (Basel, Switzerland).
2021 Jan; 26(2):. doi:
10.3390/molecules26020406
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European journal of medicinal chemistry.
2021 Jan; 209(?):112932. doi:
10.1016/j.ejmech.2020.112932
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Toxins.
2020 12; 12(12):. doi:
10.3390/toxins12120794
. [PMID: 33322178] - Gang Wang, Yang Yu, Yu-Zhu Wang, Zhi-Min Zhu, Pei-Hao Yin, Ke Xu. Effects and mechanisms of fatty acid metabolism‑mediated glycolysis regulated by betulinic acid‑loaded nanoliposomes in colorectal cancer.
Oncology reports.
2020 12; 44(6):2595-2609. doi:
10.3892/or.2020.7787
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Natural product research.
2020 Dec; 34(23):3313-3319. doi:
10.1080/14786419.2019.1566822
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Antiviral research.
2020 12; 184(?):104954. doi:
10.1016/j.antiviral.2020.104954
. [PMID: 33080251] - Feng Zhang, Jian Huang, Rong-Jing He, Lu Wang, Peng-Chao Huo, Xiao-Qing Guan, Sheng-Quan Fang, Yan-Wei Xiang, Shou-Ning Jia, Guang-Bo Ge. Herb-drug interaction between Styrax and warfarin: Molecular basis and mechanism.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Oct; 77(?):153287. doi:
10.1016/j.phymed.2020.153287
. [PMID: 32739573] - Ebrahim Azadniya, Luca Goldoni, Tiziano Bandiera, Gertrud E Morlock. Same analytical method for both (bio)assay and zone isolation to identify/quantify bioactive compounds by quantitative nuclear magnetic resonance spectroscopy.
Journal of chromatography. A.
2020 Sep; 1628(?):461434. doi:
10.1016/j.chroma.2020.461434
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Bioorganic & medicinal chemistry letters.
2020 09; 30(17):127407. doi:
10.1016/j.bmcl.2020.127407
. [PMID: 32738992] - Qian Mu, Hui Wang, Lei Tong, Qianhua Fang, Minqi Xiang, Luyu Han, Lina Jin, Jian Yang, Zhen Qian, Guang Ning, Yifei Zhang, Zhiguo Zhang. Betulinic acid improves nonalcoholic fatty liver disease through YY1/FAS signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 09; 34(9):13033-13048. doi:
10.1096/fj.202000546r
. [PMID: 32777136] - Lijuan Zhu, Xianglian Yi, Chaoyang Ma, Chenxi Luo, Li Kong, Xing Lin, Xinyu Gao, Zhihang Yuan, Lixin Wen, Rongfang Li, Jing Wu, Jine Yi. Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway.
Toxins.
2020 08; 12(9):. doi:
10.3390/toxins12090540
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BMC plant biology.
2020 Aug; 20(1):374. doi:
10.1186/s12870-020-02521-1
. [PMID: 32787836] - Ângela R Guerra, Ana F Paulino, Maria M Castro, Helena Oliveira, Maria F Duarte, Iola F Duarte. Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids.
Biomolecules.
2020 08; 10(8):. doi:
10.3390/biom10081163
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Molecular informatics.
2020 08; 39(8):e2000028. doi:
10.1002/minf.202000028
. [PMID: 32162456] - Yun Chen, Xiongjian Wu, Chi Liu, Yun Zhou. Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress.
Cell biochemistry and function.
2020 Aug; 38(6):702-709. doi:
10.1002/cbf.3537
. [PMID: 32283563] - Michał Sulik, Ewa Maj, Joanna Wietrzyk, Adam Huczyński, Michał Antoszczak. Synthesis and Anticancer Activity of Dimeric Polyether Ionophores.
Biomolecules.
2020 07; 10(7):. doi:
10.3390/biom10071039
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Molecular pharmaceutics.
2020 07; 17(7):2546-2554. doi:
10.1021/acs.molpharmaceut.0c00244
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Plant science : an international journal of experimental plant biology.
2020 May; 294(?):110433. doi:
10.1016/j.plantsci.2020.110433
. [PMID: 32234222] - R A Ajala-Lawal, N O Aliyu, T O Ajiboye. Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome rats via PI3K/Akt pathways.
Archives of physiology and biochemistry.
2020 May; 126(2):107-115. doi:
10.1080/13813455.2018.1498901
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Journal of natural products.
2020 04; 83(4):1174-1182. doi:
10.1021/acs.jnatprod.9b01212
. [PMID: 32237724] - Victor Constante Oliveira, Maria Paula Carvalho Naves, Cássio Resende de Morais, Sarah Alves Rodrigues Constante, Priscila Capelari Orsolin, Bianca Silva Alves, Francisco Rinaldi Neto, Lucas Henrique Domingos da Silva, Lucas Teixeira Souza de Oliveira, Natália Helen Ferreira, Tábata Rodrigues Esperandim, Wilson Roberto Cunha, Denise Crispim Tavares, Mário Antônio Spanó. Betulinic acid modulates urethane-induced genotoxicity and mutagenicity in mice and Drosophila melanogaster.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Apr; 138(?):111228. doi:
10.1016/j.fct.2020.111228
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Biomolecules.
2020 03; 10(4):. doi:
10.3390/biom10040510
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Bioorganic & medicinal chemistry.
2020 03; 28(5):115229. doi:
10.1016/j.bmc.2019.115229
. [PMID: 32033878] - Yao-Yao Bai, Dong Yan, Hui-Ying Zhou, Wei-Xin Li, Yang-Yun Lou, Xin-Ru Zhou, Ling-Bo Qian, Chi Xiao. Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity in the rat aorta by modulating Nrf2 antioxidative function.
Inflammopharmacology.
2020 Feb; 28(1):165-174. doi:
10.1007/s10787-019-00622-4
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Steroids.
2020 02; 154(?):108530. doi:
10.1016/j.steroids.2019.108530
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Zeitschrift fur Naturforschung. C, Journal of biosciences.
2020 Jan; 75(1-2):51-56. doi:
10.1515/znc-2018-0217
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International journal of immunopathology and pharmacology.
2020 Jan; 34(?):2058738420945078. doi:
10.1177/2058738420945078
. [PMID: 32718263] - Gang Wang, Yu-Zhu Wang, Yang Yu, Jun-Jie Wang, Pei-Hao Yin, Ke Xu. Triterpenoids Extracted from Rhus chinensis Mill Act Against Colorectal Cancer by Inhibiting Enzymes in Glycolysis and Glutaminolysis: Network Analysis and Experimental Validation.
Nutrition and cancer.
2020; 72(2):293-319. doi:
10.1080/01635581.2019.1631858
. [PMID: 31267795] - Xin Jin, Qing Yang, Ning Cai, Zhenhai Zhang. A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.
Nanomedicine (London, England).
2020 01; 15(1):41-54. doi:
10.2217/nnm-2018-0479
. [PMID: 31868113] - Tatyana S Khlebnicova, Yuri A Piven, Fedor A Lakhvich, Iryna V Sorokina, Tatiana S Frolova, Dmitry S Baev, Tatyana G Tolstikova. Betulinic Acid-Azaprostanoid Hybrids: Synthesis and Pharmacological Evaluation as Anti-inflammatory Agents.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2020; 19(3):254-267. doi:
10.2174/1871523018666190426152049
. [PMID: 33001006] - Dongfang Xiang, Min Zhao, Xiaofan Cai, Yongxia Wang, Lei Zhang, Helen Yao, Min Liu, Huan Yang, Mingtao Xu, Huilin Li, Huijuan Peng, Min Wang, Xuefang Liang, Ling Li, Paul Yao. Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor β Signaling Pathway.
Frontiers in endocrinology.
2020; 11(?):604648. doi:
10.3389/fendo.2020.604648
. [PMID: 33362719] - Ran Tao, Chengzhang Wang, Yin Lu, Changwei Zhang, Hao Zhou, Hongxia Chen, WenJun Li. Characterization and Cytotoxicity of Polyprenol Lipid and Vitamin E-TPGS Hybrid Nanoparticles for Betulinic Acid and Low-Substituted Hydroxyl Fullerenol in MHCC97H and L02 Cells.
International journal of nanomedicine.
2020; 15(?):2733-2749. doi:
10.2147/ijn.s249773
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Natural product research.
2019 Nov; 33(22):3287-3292. doi:
10.1080/14786419.2018.1470171
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Molecules (Basel, Switzerland).
2019 Oct; 24(21):. doi:
10.3390/molecules24213939
. [PMID: 31683639] - Xihong Wang, Zhihang Yuan, Lijuan Zhu, Xianglian Yi, Zhaoping Ou, Rongfang Li, Zhuliang Tan, Blazej Pozniak, Bozena Obminska-Mrukowicz, Jing Wu, Jine Yi. Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice.
Pharmacological reports : PR.
2019 Oct; 71(5):929-939. doi:
10.1016/j.pharep.2019.05.004
. [PMID: 31450028] - Navneet Kishore, Pradeep Kumar, Karuna Shanker, Akhilesh Kumar Verma. Human disorders associated with inflammation and the evolving role of natural products to overcome.
European journal of medicinal chemistry.
2019 Oct; 179(?):272-309. doi:
10.1016/j.ejmech.2019.06.034
. [PMID: 31255927] - Jiajian Huang, Wenlong Zha, Tianyue An, Hua Dong, Ying Huang, Dong Wang, Rongmin Yu, Lixin Duan, Xueli Zhang, Reuben J Peters, Zhubo Dai, Jiachen Zi. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid.
Applied microbiology and biotechnology.
2019 Sep; 103(17):7029-7039. doi:
10.1007/s00253-019-10004-z
. [PMID: 31309269] - Al-Mutary Mohsen G, Gasem Mohammad Abu-Taweel, Rajakrishnan Rajagopal, Kim Sun-Ju, Hak-Jae Kim, Young Ock Kim, Ramzi A Mothana, Shine Kadaikunnan, Jamal M Khaled, Nasir A Siddiqui, Adnan J Al-Rehaily. Betulinic acid lowers lipid accumulation in adipocytes through enhanced NCoA1-PPARγ interaction.
Journal of infection and public health.
2019 Sep; 12(5):726-732. doi:
10.1016/j.jiph.2019.05.011
. [PMID: 31133421] - Herong Cui, Wenbo Guo, Beibei Zhang, Guoping Li, Tong Li, Yanyan Yuan, Na Zhang, Yuwei Yang, Wuwen Feng, Fuhao Chu, Shenglan Wang, Bing Xu, Penglong Wang, Haimin Lei. BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation.
International journal of molecular sciences.
2019 Aug; 20(16):. doi:
10.3390/ijms20164062
. [PMID: 31434286] - Debasmita Dutta, Brahamacharry Paul, Biswajit Mukherjee, Laboni Mondal, Suparna Sen, Chinmay Chowdhury, Mita Chatterjee Debnath. Nanoencapsulated betulinic acid analogue distinctively improves colorectal carcinoma in vitro and in vivo.
Scientific reports.
2019 08; 9(1):11506. doi:
10.1038/s41598-019-47743-y
. [PMID: 31395908] - Cuihua Liu, Yuchao Chen, Chuanjian Lu, Haiming Chen, Jingwen Deng, Yuhong Yan, Yong-Yue Xu, Huazhen Liu, Haiding Huang, Jianan Wei, Ling Han, Zhenhua Dai. Betulinic acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation.
International immunopharmacology.
2019 Aug; 73(?):343-352. doi:
10.1016/j.intimp.2019.05.030
. [PMID: 31129421] - Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Yuri Ko, Changhyun Pang, Noriko Yamabe, Ki Hyun Kim. Betulinic Acid Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis.
Biomolecules.
2019 07; 9(7):. doi:
10.3390/biom9070257
. [PMID: 31277238] - Anqi Zeng, Hua Hua, Li Liu, Junning Zhao. Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo.
Bioorganic & medicinal chemistry.
2019 06; 27(12):2546-2552. doi:
10.1016/j.bmc.2019.03.033
. [PMID: 30910472] - Alexsander Rodrigues Carvalho Junior, Arthur Lima de Berredo Martins, Brenda da Silva Cutrim, Deivid Martins Santos, Hermerson Sousa Maia, Mari Silma Maia da Silva, Adrielle Zagmignan, Maria Raimunda Chagas Silva, Cristina de Andrade Monteiro, Giselle Maria Skelding Pinheiro Guilhon, Antônio José Cantanhede Filho, Luís Cláudio Nascimento da Silva. Betulinic Acid Prevents the Acquisition of Ciprofloxacin-Mediated Mutagenesis in Staphylococcus aureus.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091757
. [PMID: 31067626] - Shicheng Zhao, Chang Ha Park, Jingli Yang, Hyeon Ji Yeo, Tae Jin Kim, Jae Kwang Kim, Sang Un Park. Molecular characterization of anthocyanin and betulinic acid biosynthesis in red and white mulberry fruits using high-throughput sequencing.
Food chemistry.
2019 May; 279(?):364-372. doi:
10.1016/j.foodchem.2018.11.101
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Nutrition, metabolism, and cardiovascular diseases : NMCD.
2019 04; 29(4):409-420. doi:
10.1016/j.numecd.2018.12.001
. [PMID: 30799179] - Ming Gu, Ping Zhao, Shiying Zhang, Shengjie Fan, Li Yang, Qingchun Tong, Guang Ji, Cheng Huang. Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice.
British journal of pharmacology.
2019 04; 176(7):847-863. doi:
10.1111/bph.14570
. [PMID: 30635917] - Nan Yao, Chenran Wang, Nan Hu, Yingjie Li, Mingqun Liu, Yuhe Lei, Minfeng Chen, Liping Chen, Chen Chen, Ping Lan, Weimin Chen, Zhesheng Chen, Dengrui Fu, Wencai Ye, Dongmei Zhang. Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog.
Cell death & disease.
2019 03; 10(3):232. doi:
10.1038/s41419-019-1470-z
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