physcion (BioDeep_00000267309)

Main id: BioDeep_00000000367

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- (9CI)

化学式: C16H12O5 (284.0684702)
中文名称: 大黄素甲醚
谱图信息: 最多检出来源 Homo sapiens(natural_products) 50%

分子结构信息

SMILES: c1(cc(c2c(c1)C(=O)c1c(C2=O)c(cc(c1)C)O)O)OC
InChI: InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3

描述信息

Physcion, also known as emodin monomethyl ether or parienin, is a member of the class of compounds known as anthraquinones. Anthraquinones are organic compounds containing either anthracene-9,10-quinone, 1,4-anthraquinone, or 1,2-anthraquinone. Physcion is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Physcion can be synthesized from 2-methylanthraquinone. Physcion can also be synthesized into torososide B and physcion 8-gentiobioside. Physcion can be found in common sage, garden rhubarb, and sorrel, which makes physcion a potential biomarker for the consumption of these food products. Physcion has also been shown to protect lichens against UV-B light, at high altitudes in Alpine regions. The UV-B light stimulates production of parietin and the parietin protects the lichens from damage. Lichens in arctic regions such as Svarlbard retain this capability though they do not encounter damaging levels of UV-B, a capability that could help protect the lichens in case of Ozone layer thinning .

同义名列表

51 个代谢物同义名

physcion; 9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- (9CI); 9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl-; 1,8-dihydroxy-3-methoxy-6-methyl-anthracene-9,10-dione; 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione; 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione; 1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone; 1,8-Dihydroxy-3-methyl-6-methoxy-9,10-anthraquinone; ANTHRAQUINONE, 1,8-DIHYDROXY-3-METHOXY-6-METHYL-; 1,8-Dihydroxy-3-methoxy-6-methyl-anthraquinone; 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone; emodin 3-methyl ether; SDCCGMLS-0066772.P001; Emodin-3-methyl ether; Spectrum3_001829; Spectrum4_000909; Spectrum2_000503; EINECS 208-315-7; Spectrum5_001742; SPECTRUM1504070; NCGC00096075-01; Spectrum_001782; SpecPlus_000471; Methoxyemodin; KBioGR_001378; MEGxm0_000018; KBioSS_002265; DivK1c_006567; Rheochrysidin; BSPBio_003477; KBio1_001511; KBio2_004832; KBio2_007400; SPBio_000425; KBio2_002264; NCI60_002011; ZINC03978794; KBio3_002981; CHEBI:38167; BRN 1915778; AIDS-014879; 17797_FLUKA; NSC 251670; AIDS014879; CCRIS 4399; Physcione; NSC251670; parietin; 521-61-9; Rheochrysidin_120098; 1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

608 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lu Liu, Sen Sun, Xiaohua Li. Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes. Pharmaceutical biology. 2024 Dec; 62(1):207-213. doi: 10.1080/13880209.2024.2314089. [PMID: 38353248]
  • Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
  • Ruojun Du, Lichun Ye, Xinyan Chen, Yan Meng, Lei Zhou, Qiao Chen, Guohua Zheng, Junjie Hu, Zhaohua Shi. Screening of Key Components for Melanogenesis Inhibition of Polygonum cuspidatum Extract Based on the Spectrum-Effect Relationship and Molecular Docking. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040857. [PMID: 38398609]
  • Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
  • Mohamed Mendili, Ayda Khadhri, Francesca Sabatini, Ilaria Degano, Samira Aschi-Smiti. Parietin, the Vibrant Natural Dye in Xanthoria parietina. Chemistry & biodiversity. 2024 Jan; 21(1):e202301357. doi: 10.1002/cbdv.202301357. [PMID: 38072912]
  • Jan Schulze, Lisa Schöne, Abdallah M Ayoub, Damiano Librizzi, Muhammad Umair Amin, Konrad Engelhardt, Behrooz H Yousefi, Lena Bender, Jens Schaefer, Eduard Preis, Michaela Schulz-Siegmund, Christian Wölk, Udo Bakowsky. Modern Photodynamic Glioblastoma Therapy Using Curcumin- or Parietin-Loaded Lipid Nanoparticles in a CAM Model Study. ACS applied bio materials. 2023 Dec; 6(12):5502-5514. doi: 10.1021/acsabm.3c00695. [PMID: 38016693]
  • Shuxiang Zhang, Zhongdi Huang, Huanhuan Xu, Qihua Liu, Zhou Jiang, Caiping Yin, Guomin Han, Wei Zhang, Yinglao Zhang. Biological control of wheat powdery mildew disease by the termite-associated fungus Aspergillus chevalieri BYST01 and potential role of secondary metabolites. Pest management science. 2023 Dec; ?(?):. doi: 10.1002/ps.7938. [PMID: 38105413]
  • Martyna Nowak-Perlak, Piotr Ziółkowski, Marta Woźniak. A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Oct; 119(?):155035. doi: 10.1016/j.phymed.2023.155035. [PMID: 37603973]
  • ShengHao Chen, YanLan Liang, YuanYuan Li, Yue Sun, Yang He. Determination of rhein and physcion in rhubarb by microchip capillary electrophoresis in mixed hydro-organic solvent combined with laser-induced fluorescence detection. Journal of separation science. 2023 Jul; ?(?):e2300192. doi: 10.1002/jssc.202300192. [PMID: 37507831]
  • H Wang, M Li, S Li, J Shi, L Huang, S Cheng, C Zou, H Yan. [Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 May; 43(5):825-831. doi: 10.12122/j.issn.1673-4254.2023.05.19. [PMID: 37313825]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Hanaa M Sayed, Mahmoud A Ramadan, Heba H Salem, Iqrar Ahmad, Harun Patel, Marwa A A Fayed. Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L. Steroids. 2023 May; 196(?):109245. doi: 10.1016/j.steroids.2023.109245. [PMID: 37141980]
  • Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
  • Yongpeng Yao, ErLan Yang, Yuanyuan Pan, Xian Shu, Gang Liu. Mining an O-methyltransferase for de novo biosynthesis of physcion in Aspergillus nidulans. Applied microbiology and biotechnology. 2023 Feb; 107(4):1177-1188. doi: 10.1007/s00253-023-12373-y. [PMID: 36648527]
  • Feifei Qi, Wei Zhang, Yingying Xue, Ce Geng, Zhigang Jin, Jibin Li, Qiang Guo, Xuenian Huang, Xuefeng Lu. Microbial production of the plant-derived fungicide physcion. Metabolic engineering. 2022 11; 74(?):130-138. doi: 10.1016/j.ymben.2022.10.007. [PMID: 36328293]
  • Bo Yuan, Nancy P Keller, Berl R Oakley, Jason E Stajich, Clay C C Wang. Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins. ACS chemical biology. 2022 10; 17(10):2828-2835. doi: 10.1021/acschembio.2c00456. [PMID: 36197945]
  • Xiaolei Du, Lili Xu, Zhe Zhang, Yang Wang, Huifen Li, Weiliang Cui, Huibin Lin. Analyze the Effect of Steaming on the Chemical Constituents, Defecation and Liver Injury of Polygonum Multiflorum Radix (Heshouwu) by Multiple Analysis Techniques Combined with Multivariate Statistics. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196284. [PMID: 36234820]
  • Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang. A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112482. doi: 10.1016/j.biopha.2021.112482. [PMID: 34915669]
  • Zizhao Lao, Yaohua Fan, Yuhang Huo, Feng Liao, Rongwen Zhang, Bei Zhang, Ziyun Kong, Haishan Long, Jieliang Xie, Chuanlan Sang, Ludi Fu, Ji Lin, Yina Wu, Liangwen Yu, Geng Li. Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo. Archives of dermatological research. 2022 Jan; 314(1):41-51. doi: 10.1007/s00403-021-02195-1. [PMID: 33635414]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Xiao Wei Ji, Hang Ji Lyu, Guang Hai Zhou, Bo Wu, Yuan Yuan Zhu, Tian Hua Wu, Feng Zhang, Song Nan Jin, Kyung Woo Cho, Jin Fu Wen. Physcion, a tetra-substituted 9,10-anthraquinone, prevents homocysteine-induced endothelial dysfunction by activating Ca2+- and Akt-eNOS-NO signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jan; 81(?):153410. doi: 10.1016/j.phymed.2020.153410. [PMID: 33285470]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • XunLi, Yingjiao Liu, Shifeng Chu, Songwei Yang, Ye Peng, Siyu Ren, Birui Wen, Naihong Chen. Physcion and physcion 8-O-β-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics. Chemico-biological interactions. 2019 Sep; 310(?):108722. doi: 10.1016/j.cbi.2019.06.035. [PMID: 31226286]
  • Bing Yang, Li Xie, Siying Peng, Kanping Sun, Junjie Jin, Yanping Zhen, Kunming Qin, Baochang Cai. Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats. Journal of separation science. 2019 Jul; 42(14):2341-2350. doi: 10.1002/jssc.201900007. [PMID: 31037812]
  • Rong-Rong Li, Xue-Fang Liu, Su-Xiang Feng, Sheng-Nan Shu, Pei-Yang Wang, Na Zhang, Jian-Sheng Li, Ling-Bo Qu. Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101898. [PMID: 31108858]
  • Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Sungwei Hong, Min-Sun Yoo, Hyeong-Jin Kim, Ji-Hyeon Kim, Soonsik Kang, Hyun-Woo Jee, Hyung-Min Kim, Hyun-Ja Jeong. Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081484. [PMID: 30991764]
  • Kun-Ze Du, Ying Chen, Jin Li, Ge Tang, Fei Tian, Jun He, Yanxu Chang. Quantification of eight active ingredients in crude and processed radix polygoni multiflori applying miniaturized matrix solid-phase dispersion microextraction followed by UHPLC. Journal of separation science. 2018 Sep; 41(17):3486-3495. doi: 10.1002/jssc.201800342. [PMID: 30028075]
  • Ki Sun Kwon, Ju Hee Lee, Kyung Su So, Byung Kyu Park, Hyun Lim, Jae Sue Choi, Hyun Pyo Kim. Aurantio-obtusin, an anthraquinone from cassiae semen, ameliorates lung inflammatory responses. Phytotherapy research : PTR. 2018 Aug; 32(8):1537-1545. doi: 10.1002/ptr.6082. [PMID: 29675883]
  • Beatriz Fernández-Marín, Unai Artetxe, José María Becerril, Javier Martínez-Abaigar, Encarnación Núñez-Olivera, José Ignacio García-Plazaola. Can Parietin Transfer Energy Radiatively to Photosynthetic Pigments?. Molecules (Basel, Switzerland). 2018 Jul; 23(7):. doi: 10.3390/molecules23071741. [PMID: 30018202]
  • Guo Feng, Yun-Long Chen, Wei Li, Lai-Lai Li, Zeng-Guang Wu, Zi-Jun Wu, Yue Hai, Si-Chao Zhang, Chuan-Qi Zheng, Chang-Xiao Liu, Xin He. Exploring the Q-marker of "sweat soaking method" processed radix Wikstroemia indica: Based on the "effect-toxicity-chemicals" study. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):49-58. doi: 10.1016/j.phymed.2018.03.063. [PMID: 29691116]
  • Xiaotong Qin, Ying Peng, Jiang Zheng. In Vitro and in Vivo Studies of the Electrophilicity of Physcion and its Oxidative Metabolites. Chemical research in toxicology. 2018 05; 31(5):340-349. doi: 10.1021/acs.chemrestox.8b00026. [PMID: 29667811]
  • Ulrich Hildebrandt, Alexander Marsell, Markus Riederer. Direct Effects of Physcion, Chrysophanol, Emodin, and Pachybasin on Germination and Appressorium Formation of the Barley ( Hordeum vulgare L.) Powdery Mildew Fungus Blumeria graminis f. sp. hordei (DC.) Speer. Journal of agricultural and food chemistry. 2018 Apr; 66(13):3393-3401. doi: 10.1021/acs.jafc.7b05977. [PMID: 29554805]
  • Jing Zhang, Tenghua Wang, Zhiyao Ren, Lu Gong, Juan Huang, Junqi Bai, Xiaohui Qiu, Wen Xu. Application of HPLC-LTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats. Biomedical chromatography : BMC. 2018 Feb; 32(2):. doi: 10.1002/bmc.4067. [PMID: 28833268]
  • Renato Sonchini Gonçalves, Expedito Leite Silva, Noboru Hioka, Celso Vataru Nakamura, Marcos Luciano Bruschi, Wilker Caetano. An optimized protocol for anthraquinones isolation from Rhamnus frangula L. Natural product research. 2018 Feb; 32(3):366-369. doi: 10.1080/14786419.2017.1356836. [PMID: 28745519]
  • Thais Fernanda Moreira, Juliana Maria Sorbo, Felipe de Oliveira Souza, Barbara Colatto Fernandes, Fernanda Maria Marins Ocampos, Daniella Maria Soares de Oliveira, Carlos Alberto Arcaro, Renata Pires Assis, Andersson Barison, Obdulio Gomes Miguel, Amanda Martins Baviera, Christiane Pienna Soares, Iguatemy Lourenço Brunetti. Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines. Oxidative medicine and cellular longevity. 2018; 2018(?):2390234. doi: 10.1155/2018/2390234. [PMID: 30057674]
  • Li Kang, Luqin Si, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Apr; 40(?):313-323. doi: 10.1016/j.tiv.2017.01.022. [PMID: 28161596]
  • Jianhui Cheng, Lingyu Wang, Weifen Liu, David D Y Chen. Quantitative Nonaqueous Capillary Electrophoresis-Mass Spectrometry Method for Determining Active Ingredients in Plant Extracts. Analytical chemistry. 2017 02; 89(3):1411-1415. doi: 10.1021/acs.analchem.6b04944. [PMID: 28208307]
  • Ming-Jie Pang, Zhun Yang, Xing-Lin Zhang, Zhao-Fang Liu, Jun Fan, Hong-Ying Zhang. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta pharmacologica Sinica. 2016 Dec; 37(12):1623-1640. doi: 10.1038/aps.2016.98. [PMID: 27694907]
  • Di Zhang, Yantao Han, Luo Xu. Upregulation of miR-124 by physcion 8-O-β-glucopyranoside inhibits proliferation and invasion of malignant melanoma cells via repressing RLIP76. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 12; 84(?):166-176. doi: 10.1016/j.biopha.2016.09.022. [PMID: 27657824]
  • Weiru Jiang, Xiangge Tian, Yan Wang, Zheng Sun, Peipei Dong, Chao Wang, Xiaokui Huo, Baojing Zhang, Shanshan Huang, Sa Deng, Xiaobo Wang, Xiaochi Ma. The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes. Toxicology letters. 2016 Nov; 262(?):27-38. doi: 10.1016/j.toxlet.2016.09.004. [PMID: 27633141]
  • Alberto Cornejo, Francisco Salgado, Julio Caballero, Reinaldo Vargas, Mario Simirgiotis, Carlos Areche. Secondary Metabolites in Ramalina terebrata Detected by UHPLC/ESI/MS/MS and Identification of Parietin as Tau Protein Inhibitor. International journal of molecular sciences. 2016 Aug; 17(8):. doi: 10.3390/ijms17081303. [PMID: 27548142]
  • Leslie Boudesocque-Delaye, Daniel Agostinho, Charles Bodet, Isabelle Thery-Kone, Hassan Allouchi, Alain Gueiffier, Jean-Marc Nuzillard, Cécile Enguehard-Gueiffier. Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers. Journal of natural products. 2015 Apr; 78(4):597-603. doi: 10.1021/np5003252. [PMID: 25756503]
  • Adriana Basile, Daniela Rigano, Stefano Loppi, Annalisa Di Santi, Angela Nebbioso, Sergio Sorbo, Barbara Conte, Luca Paoli, Francesca De Ruberto, Anna Maria Molinari, Lucia Altucci, Paola Bontempo. Antiproliferative, antibacterial and antifungal activity of the lichen Xanthoria parietina and its secondary metabolite parietin. International journal of molecular sciences. 2015 Apr; 16(4):7861-75. doi: 10.3390/ijms16047861. [PMID: 25860944]
  • Jiang Ma, Li Zheng, Yi-Sheng He, Hui-Jun Li. Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats. Journal of ethnopharmacology. 2015 Mar; 162(?):61-8. doi: 10.1016/j.jep.2014.12.045. [PMID: 25557036]
  • Xiao Liu, Huan Li, Li Wu, Jiangwa Xing, Yanhong Poh, Hao Cai, Bao Chang Cai. Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Feb; 980(?):88-93. doi: 10.1016/j.jchromb.2014.11.025. [PMID: 25597888]
  • Nian-Gui Xu, Zhi-Jie Xiao, Ting Zou, Zhi-Ling Huang. Ameliorative effects of physcion 8-O-β-glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by Aβ1-40. Pharmaceutical biology. 2015; 53(11):1632-8. doi: 10.3109/13880209.2014.997251. [PMID: 25856718]
  • Pan Chen, Zhi-jian Fang, Han-jing Yan, Hong-bo Zhou, Quan-xi Mei. [Study on Chemical Constituents of Petroleum Ether Fraction from Rubus alceaefolius]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jan; 38(1):93-6. doi: . [PMID: 26214876]
  • Qi-Chao Xie, Yu-Peng Yang. Anti-proliferative of physcion 8-O-β-glucopyranoside isolated from Rumex japonicus Houtt. on A549 cell lines via inducing apoptosis and cell cycle arrest. BMC complementary and alternative medicine. 2014 Oct; 14(?):377. doi: 10.1186/1472-6882-14-377. [PMID: 25283233]
  • Yan-bin Shi, Hui-li Li, Hai-qin Wang, Yan-biao Yang, Xiao-yun Zhang, Hui Wang, Zong-jie Zhu, Zhi-Ye Zhang, Cheng-an Zhang. Simultaneous determination of five anthraquinones in a Chinese traditional preparation by RP-HPLC using an improved extraction procedure. Journal of integrative medicine. 2014 Sep; 12(5):455-62. doi: 10.1016/s2095-4964(14)60037-6. [PMID: 25292345]
  • Wenjin Wu, Nan Hu, Qingwen Zhang, Yaping Li, Peng Li, Ru Yan, Yitao Wang. In vitro glucuronidation of five rhubarb anthraquinones by intestinal and liver microsomes from humans and rats. Chemico-biological interactions. 2014 Aug; 219(?):18-27. doi: 10.1016/j.cbi.2014.05.006. [PMID: 24854283]
  • Ji-wen Wang, Zhi-jian Fang, Jin-le Cheng, Han-jing Yan. [Determination of anthraquinones from different medicinal parts of Berchemia lineata by HPLC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Jun; 37(6):957-60. doi: ". [PMID: 25470957]
  • Wangen Wang, Yanran He, Pei Lin, Yunfei Li, Ruifen Sun, Wen Gu, Jie Yu, Ronghua Zhao. In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism. Journal of ethnopharmacology. 2014 May; 153(3):763-70. doi: 10.1016/j.jep.2014.03.042. [PMID: 24680992]
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